Home Other Building Blocks Tetrandrine

Tetrandrine

CAS No.:
518-34-3
Catalog Number:
AG00390G
Molecular Formula:
C38H42N2O6
Molecular Weight:
622.7499
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
99%(HPLC)powder
In Stock USA
United States
$73
- +
100mg
99%(HPLC)powder
In Stock USA
United States
$151
- +
Product Description
Catalog Number:
AG00390G
Chemical Name:
Tetrandrine
CAS Number:
518-34-3
Molecular Formula:
C38H42N2O6
Molecular Weight:
622.7499
MDL Number:
MFCD08689909
IUPAC Name:
(1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene
InChI:
InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
InChI Key:
WVTKBKWTSCPRNU-KYJUHHDHSA-N
SMILES:
COc1c(OC)cc2c3c1Oc1cc4c(cc1OC)CCN([C@H]4Cc1ccc(Oc4cc(C[C@@H]3N(CC2)C)ccc4OC)cc1)C
UNII:
29EX23D5AJ
Properties
Complexity:
979  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
622.304g/mol
Formal Charge:
0
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
622.762g/mol
Monoisotopic Mass:
622.304g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
61.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.4  
Literature
Title Journal
Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy. Environmental toxicology 20170101
Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis. Toxicology in vitro : an international journal published in association with BIBRA 20160901
CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine. Archives of toxicology 20160701
Tetrandrine induces apoptosis Via caspase-8, -9, and -3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin-1/ LC3-I, II signaling pathways in human oral cancer HSC-3 cells. Environmental toxicology 20160401
Tetrandrine ameliorates collagen-induced arthritis in mice by restoring the balance between Th17 and Treg cells via the aryl hydrocarbon receptor. Biochemical pharmacology 20160201
Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs. Toxicology and applied pharmacology 20140115
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
Tetrandrine enhances cytotoxicity of cisplatin in human drug-resistant esophageal squamous carcinoma cells by inhibition of multidrug resistance-associated protein 1. Oncology reports 20121101
Tetrandrine citrate eliminates imatinib-resistant chronic myeloid leukemia cells in vitro and in vivo by inhibiting Bcr-Abl/β-catenin axis. Journal of Zhejiang University. Science. B 20121101
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma. The Journal of biological chemistry 20121012
Discovery and preliminary SAR of bisbenzylisoquinoline alkaloids as inducers of C/EBPα. Bioorganic & medicinal chemistry 20120801
The mechanism of antibacterial activity of tetrandrine against Staphylococcus aureus. Foodborne pathogens and disease 20120801
Mechanisms of tetrandrine and 5-bromotetrandrine in reversing multidrug resistance may relate to down-regulation of multidrug resistance associated protein 7 expression. Zhongguo shi yan xue ye xue za zhi 20120601
Effect of tetrandrine on the TGF-β-induced smad signal transduction pathway in human hypertrophic scar fibroblasts in vitro. Burns : journal of the International Society for Burn Injuries 20120501
[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501
[Effects of advanced glycosylation end products and tetrandrine on proliferation of K562 and K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi 20120401
Simultaneous determination of tetrandrine and fangchinoline in herbal medicine Stephania tetrandra S. Moore by liquid chromatography with electrochemical detection. Journal of pharmaceutical and biomedical analysis 20120305
Paclitaxel/tetrandrine coloaded nanoparticles effectively promote the apoptosis of gastric cancer cells based on 'oxidation therapy'. Molecular pharmaceutics 20120206
[Effect of tetrandrine on bax, bcl-2 and TGF-β2 mRNA expressions in cultured human Tenon's capsule fibroblasts]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120101
Partial synthesis and biological evaluation of bisbenzylisoquinoline alkaloids derivatives: potential modulators of multidrug resistance in cancer. Journal of Asian natural products research 20120101
[Study on the healing effect of pneumoconiosis with tetrandrine and massive whole-lung lavage]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20120101
Tetrandrine prevents bone loss in sciatic-neurectomized mice and inhibits receptor activator of nuclear factor κB ligand-induced osteoclast differentiation. Biological & pharmaceutical bulletin 20120101
Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice. Chemical research in toxicology 20111219
H1, a derivative of Tetrandrine, exerts anti-MDR activity by initiating intrinsic apoptosis pathway and inhibiting the activation of Erk1/2 and Akt1/2. Biochemical pharmacology 20111201
Tetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cells. Toxicology in vitro : an international journal published in association with BIBRA 20111201
The interaction of telomere DNA G-quadruplex with three bis-benzyltetrahydroisoquinoline alkaloids. Nucleic acid therapeutics 20111201
Synergistic antibacterial and antibiotic effects of bisbenzylisoquinoline alkaloids on clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA). Molecules (Basel, Switzerland) 20111125
Synergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA). The Journal of toxicological sciences 20111001
The potential of tetrandrine as a protective agent for ischemic stroke. Molecules (Basel, Switzerland) 20110916
Tetrandrine induces apoptosis by activating reactive oxygen species and repressing Akt activity in human hepatocellular carcinoma. International journal of cancer 20110915
Tetrandrine suppresses amyloid-β-induced inflammatory cytokines by inhibiting NF-κB pathway in murine BV2 microglial cells. International immunopharmacology 20110901
The pharmacokinetical study of plant alkaloid tetrandrine with a simple HPLC method in rabbits. Fitoterapia 20110901
Preparation, characterization, pharmacokinetics and tissue distribution of solid lipid nanoparticles loaded with tetrandrine. AAPS PharmSciTech 20110901
Inhibition effect of tetrandrine on haze formation after Epi-LASIK surgery in rabbits. Current eye research 20110801
Enhancement of radiosensitivity and the potential mechanism on human esophageal carcinoma cells by tetrandrine. Cancer biotherapy & radiopharmaceuticals 20110801
[Effect of tetrandrine on nitroglycerin induced activation of satellite cells in trigeminal ganglia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801
Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: a clinical trial. Chinese journal of integrative medicine 20110701
H1, a novel derivative of tetrandrine reverse P-glycoprotein-mediated multidrug resistance by inhibiting transport function and expression of P-glycoprotein. Cancer chemotherapy and pharmacology 20110501
Combination of Tetrandrine with cisplatin enhances cytotoxicity through growth suppression and apoptosis in ovarian cancer in vitro and in vivo. Cancer letters 20110501
[Protective effects of tetrandrine against congenital diaphragmatic hernia in rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110501
Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42). Brain research 20110412
[Mechanisms of preventive effect of tetrandrine on acquired multidrug resistance in K562 cells]. Zhongguo shi yan xue ye xue za zhi 20110401
Efficacy of tetrandrine on lowering intraocular pressure in animal model with ocular hypertension. Journal of glaucoma 20110301
Tetrandrine induces apoptosis and triggers caspase cascade in human bladder cancer cells. The Journal of surgical research 20110301
Tetrandrine inhibits Wnt/β-catenin signaling and suppresses tumor growth of human colorectal cancer. Molecular pharmacology 20110201
Comparative nephrotoxicity of aristolochic acid and tetrandrine in vitro and in vivo. International journal of toxicology 20110201
[Inducing apoptosis and reversal effect of nilotinib in combination with tetrandrine on multidrug resistance of K562/A02 cell line]. Zhongguo shi yan xue ye xue za zhi 20110201
Effect of D, L-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and tetrandrine on the reversion of multidrug resistance in K562/A02 cells. Hematology (Amsterdam, Netherlands) 20110101
Reversion of pH-induced physiological drug resistance: a novel function of copolymeric nanoparticles. PloS one 20110101
Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats. Molecular pharmaceutics 20101206
Proteomic analysis of anti-tumor effects by tetrandrine treatment in HepG2 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Synthesis and biological activity of flavanone derivatives. Bioorganic & medicinal chemistry letters 20100915
Tetrandrine attenuates dendritic cell-mediated alloimmune responses and prolongs graft survival in mice. Planta medica 20100901
The Potential of Tetrandrine against Gliomas. Anti-cancer agents in medicinal chemistry 20100901
Enhanced cytotoxicity and activation of ROS-dependent c-Jun NH2-terminal kinase and caspase-3 by low doses of tetrandrine-loaded nanoparticles in Lovo cells--a possible Trojan strategy against cancer. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100801
Effects of tetrandrine on cAMP and cGMP levels in rabbit corpus cavernosum in vitro. Natural product research 20100701
Tetrandrine prevents acquired drug resistance of K562 cells through inhibition of mdr1 gene transcription. Journal of cancer research and clinical oncology 20100501
Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensitized mice. International immunopharmacology 20100301
Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay. Journal of biomolecular screening 20100301
Tetrandrine blocks cardiac hypertrophy by disrupting reactive oxygen species-dependent ERK1/2 signalling. British journal of pharmacology 20100201
Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice. Cancer letters 20100128
Synergistic anti-candidal activity of tetrandrine on ketoconazole: an experimental study. Planta medica 20100101
Micelle to trapping solution stacking in micellar electrokinetic chromatography. Journal of chromatography. A 20100101
Pretreatment with tetrandrine has protective effects against isoproterenol-induced myocardial infarction in rabbits. In vivo (Athens, Greece) 20100101
Protective effect of tetrandrine on doxorubicin-induced cardiotoxicity in rats. Tumori 20100101
A large-conductance (BK) potassium channel subtype affects both growth and mineralization of human osteoblasts. American journal of physiology. Cell physiology 20091201
[Pharmacokinetics of fangchinoline and tetrandrine in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201
[Inhibitive effect of tetrandrine on the proliferation of diabetes mellitus rats vascular smooth muscle cells]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091201
Tetrandrine ameliorated reperfusion injury of small bowel transplantation. Journal of pediatric surgery 20091101
[Study on the interaction of tetrandrine and bovine serum albumin]. Guang pu xue yu guang pu fen xi = Guang pu 20091101
CJX1, an amlodipine derivative, interacts with ATPase of human P-glycoprotein. Cell biology international 20091001
Ionic liquid-based ultrasound-assisted extraction of fangchinoline and tetrandrine from Stephaniae tetrandrae. Journal of separation science 20091001
[Effect of tetrandrine combined with daunorubicin on expressions of P21 and P-gp in K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi 20091001
Preparation and evaluation of PEG-PCL nanoparticles for local tetradrine delivery. International journal of pharmaceutics 20090908
Effect of prenatal tetrandrine administration on transforming growth factor-beta1 level in the lung of nitrofen-induced congenital diaphragmatic hernia rat model. Journal of pediatric surgery 20090801
Effects of tetrandrine plus radiation on neuroblastoma cells. Anticancer research 20090801
Evaluation of tetrandrine sustained release calcium alginate gel beads in vitro and in vivo. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090701
Tetrandrine suppresses tumor growth and angiogenesis of gliomas in rats. International journal of cancer 20090515
Prenatal tetrandrine treatment can reverse the abnormal conditions in the lung of newborn with congenital diaphragmatic hernia. Medical hypotheses 20090501
Mechanism of action of tetrandrine, a natural inhibitor of Candida albicans drug efflux pumps. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090501
Evaluation of the interaction of bioactive compounds in Cortex Pseudolarix and Radix Stephaniae by the microdialysis probe coupled with high performance liquid chromatography-mass spectrometry. Journal of chromatography. A 20090313
Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. Journal of veterinary science 20090301
Inhibitory effects of tetrandrine on the Na(+) channel of human atrial fibrillation myocardium. Acta pharmacologica Sinica 20090201
Tetrandrine increased the survival rate of mice with lipopolysaccharide-induced endotoxemia. The Journal of trauma 20090201
Tetrandrine ameliorates dextran-sulfate-sodium-induced colitis in mice through inhibition of nuclear factor -kappaB activation. International journal of colorectal disease 20090101
Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. The Biochemical journal 20090101
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro. Natural product research 20090101
Intervention of pyrrolidine dithiocarbamate and tetrandrine on cellular calcium overload of pancreatic acinar cells induced by serum and ascitic fluid from rats with acute pancreatitis. Journal of gastroenterology and hepatology 20090101
[Application of numerical convolution in in vivo/in vitro correlation research]. Yao xue xue bao = Acta pharmaceutica Sinica 20090101
Tetrandrine protects mice from concanavalin A-induced hepatitis through inhibiting NF-kappaB activation. Immunology letters 20081222
Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20081104
[Biomolecular mechanisms of cyclosporine A, tetrandrine and their combination on the reversion of multidrug resistance in human leukemia cell line]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081101
[Inhibitory effect of tetrandrine on angiogenesis]. Ai zheng = Aizheng = Chinese journal of cancer 20081001
[The study of anti-tumor effect of Tetrandrine combined with Nedaplatin on human liver cancer cell line 7402]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081001
[Experimental study on therapeutic efficacy of tetrandrine on lung injury induced by acute of paraquat poisoning]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20081001
Anticancer effect of tetrandrine on primary cancer cells isolated from ascites and pleural fluids. Cancer letters 20080908
[Effects of tetrandrine on nuclear factor-kappaB expression in leukemia multidrug-resistant cell line K562/A02]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080901
Effects of tetrandrine on ischemia/reperfusion injury in mouse liver. Transplantation proceedings 20080901
Tetrandrine suppresses LPS-induced astrocyte activation via modulating IKKs-IkappaBalpha-NF-kappaB signaling pathway. Molecular and cellular biochemistry 20080801
Effects of arecoline on testosterone release in rats. American journal of physiology. Endocrinology and metabolism 20080801
Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells. European journal of pharmacology 20080728
Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis. Cancer biology & therapy 20080701
Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro. Current eye research 20080701
GSK-3beta is a critical mediator of tetrandrine induced cell cycle arrest and cytotoxicity. Cancer biology & therapy 20080701
[Effect of tetrandrine on the doxorubicin-induced expression of mdr1 gene in K562 cells]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20080701
Reversal in multidrug resistance by magnetic nanoparticle of Fe3O4 loaded with adriamycin and tetrandrine in K562/A02 leukemic cells. International journal of nanomedicine 20080601
[Comparison of reversal effects of 5-bromotetrandrine and tetrandrine on P-glycoprotein-dependent Resistance to adriamycin in human lukemia cell line K562/A02]. Ai zheng = Aizheng = Chinese journal of cancer 20080501
Reversal effect of isotetrandrine, an isoquinoline alkaloid extracted from Caulis Mahoniae, on P-glycoprotein-mediated doxorubicin-resistance in human breast cancer (MCF-7/DOX) cells. Yao xue xue bao = Acta pharmaceutica Sinica 20080501
[Effect of tetrandrine in combination with droloxifen on the expression of NF-kappaB protein in K562 and K562/A02 cell lines]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20080501
Effect of tetrandrine combined with epirubicin on the growth of human breast carcinoma multidrug resistance cell line. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080401
Studies on alkaloids binding to GC-rich human survivin promoter DNA using positive and negative ion electrospray ionization mass spectrometry. Journal of mass spectrometry : JMS 20080301
Preparation of chitosan-gelatin scaffold containing tetrandrine-loaded nano-aggregates and its controlled release behavior. International journal of pharmaceutics 20080227
Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-kappaB pathway. Acta pharmacologica Sinica 20080201
[Effect of tetrandrine, toremifene and their combination on the reversion of multidrug resistance of K562/A02 cell line]. Zhongguo shi yan xue ye xue za zhi 20080201
[Influence of tetrandrine on SORCIN gene expression in K562/A02 cell line]. Zhongguo shi yan xue ye xue za zhi 20080201
Synthesis and characterization of microparticles made of carboxymethyloxysuccinic-acid-modified PLA-PEG co-polymer. Journal of biomaterials science. Polymer edition 20080101
[Preparation of tetrandrine alginate calcium sustained release gel pellets]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101
Tetrandrine: a potent abrogator of G2 checkpoint function in tumor cells and its mechanism. Biomedical and environmental sciences : BES 20071201
Effects of tetrandrine on apoptosis and radiosensitivity of nasopharyngeal carcinoma cell line CNE. Acta biochimica et biophysica Sinica 20071101
[Effects of tetrandrine on pulmonary capillary permeability in rats with acute lung injury induced by lipopolysaccharide]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20071101
Synergistic interaction between tetrandrine and chemotherapeutic agents and influence of tetrandrine on chemotherapeutic agent-associated genes in human gastric cancer cell lines. Cancer chemotherapy and pharmacology 20071001
Tetrandrine achieved plasma concentrations capable of reversing MDR in vitro and had no apparent effect on doxorubicin pharmacokinetics in mice. Cancer chemotherapy and pharmacology 20071001
Heat shock proteins and p53 play a critical role in K+ channel-mediated tumor cell proliferation and apoptosis. Apoptosis : an international journal on programmed cell death 20071001
Effect of antenatal tetrandrine administration on endothelin-1 and epidermal growth factor levels in the lungs of rats with experimental diaphragmatic hernia. Journal of pediatric surgery 20071001
[Determination of tetrandrine and fangchinoline in Radix Stephaniae tetrandrae and its preparation by nonaqueous capillary chromatography]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071001
Determination of tetrandrine and fangchinoline in plasma samples using hollow fiber liquid-phase microextraction combined with high-performance liquid chromatography. Journal of chromatography. A 20070914
[Effects of tetrandrine on Ang II-induced cardiomyocyte hypertrophy and p-ERK1/2 expression]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901
[Effect of tetrandrine on lung development: experiment of nitrofen-induced congenital diaphragmatic hernia fetal rat model]. Zhonghua yi xue za zhi 20070828
[Reversing multidrug resistance of epidermoid carcinoma drug-resistant cell line KB-MRP1 by tetrandrine]. Ai zheng = Aizheng = Chinese journal of cancer 20070801
[Inhibiting effects of tetrandrine on capsular contraculture in rabbits]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20070701
[Effect of Chinese herbal drugs and tetrandrine on TGF-beta1 signaling pathway]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20070601
Interaction of tetrandrine with human serum albumin: a fluorescence quenching study. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070401
[The intervention of tetrandrine in the acute renal injury induced by streptomycin sulfate in puinea pigs]. Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20070401
Tetrandrine stimulates the apoptosis of hepatic stellate cells and ameliorates development of fibrosis in a thioacetamide rat model. World journal of gastroenterology 20070227
[Effect of tetrandrine on endothelin expression in the lungs and clinical significance thereof: experiment with rat models with nitrofen-induced congenital diaphragmatic hernia]. Zhonghua yi xue za zhi 20070206
Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis. Journal of gastroenterology and hepatology 20070101
Tetrandrine inhibits proinflammatory cytokines, iNOS and COX-2 expression in human monocytic cells. Biological & pharmaceutical bulletin 20070101
[Simultaneous analysis of six effective components in the anti-Alzheimer's disease effective component group of Xiao-Xu-Ming Decoction]. Se pu = Chinese journal of chromatography 20070101
Inhibition of tetrandrine on epidermal growth factor-induced cell transformation and its signal transduction. Anticancer research 20070101
Tetrandrine selectively protects against amyloid-beta protein - but not against MPTP-induced cytotoxicity in SK-N-SH neuroblastoma cells. Planta medica 20061101
[Effect and significance of tetrandrine on epidermal growth factor and its receptor in the lung of congenital diaphragmatic hernia rat model]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20061101
[The effects of tetrandrine on activity of collagenase derived from human hypertrophic scar]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20061101
[The effects of Tetrandrine on the changes of IL-1beta, TNF-alpha and IL-8 after cerebral ischemia/reperfusion in rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20061101
[Preparation of tetrandrine solid lipid nanoparticles]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20061001
Anti-fibrotic effects of tetrandrine on bile-duct ligated rats. Canadian journal of physiology and pharmacology 20061001
[An experimental study on the inhibition effect of corneal allograft rejection in rat by local application of Tetrandrine eye drops]. Yan ke xue bao = Eye science 20060901
Tetrandrine concentrations not affecting oxidative phosphorylation protect rat liver mitochondria from oxidative stress. Mitochondrion 20060801
Effect of Tetrandrine on LPS-induced NF-kappaB activation in isolated pancreatic acinar cells of rat. World journal of gastroenterology 20060714
Silica-induced apoptosis in alveolar macrophages: evidence of in vivo thiol depletion and the activation of mitochondrial pathway. Journal of toxicology and environmental health. Part A 20060701
Effects of tetrandrine on cytosolic free calcium concentration in corpus cavernosum smooth muscle cells of rabbits. Asian journal of andrology 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060501
Combination of tetrandrine as a potential-reversing agent with daunorubicin, etoposide and cytarabine for the treatment of refractory and relapsed acute myelogenous leukemia. Leukemia research 20060401
[Study on protective effect of tetrandrine on lipopolysaccharide induced pancreatic acinar cell damage and its mechanism]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060301
Detection of aristolochic acid I, tetrandrine and fangchinoline in medicinal plants by high performance liquid chromatography and liquid chromatography/mass spectrometry. Journal of pharmaceutical and biomedical analysis 20060224
Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: caspases and endonuclease G (Endo G) pathway. Toxicology 20060120
Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines. The American journal of Chinese medicine 20060101
[Trials of casual treatment of silicosis]. Medycyna pracy 20060101
Separation and determination of tetrandrine and fangchinoline in herbal medicines by flow injection-micellar electrokinetic capillary chromatography with internal standard method. Journal of chromatography. A 20051209
Online concentration by field-amplified sample injection in acidic buffer for analysis of fangchinoline and tetrandrine in herbal medicine by flow injection-micellar electrokinetic capillary chromatography. Electrophoresis 20051201
[Using protein chips to study mechanism underlying reversion of drug resistance in leukemia cells in tetrandrine alone or in combination with droloxifene]. Zhongguo shi yan xue ye xue za zhi 20051201
[The interference in correlated molecular mechanism obtained multi-drug resistance of mouse S180's tumour cell for different alkaloid]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051201
Effect of tetrandrine on calcium-dependent tumour necrosis factor-alpha production in glia-neurone mixed cultures. Basic & clinical pharmacology & toxicology 20051001
Tetrandrine inhibits activation of rat hepatic stellate cells stimulated by transforming growth factor-beta in vitro via up-regulation of Smad 7. Journal of ethnopharmacology 20050914
[Effects of tetrandrine on transmembrane signaling in rat hepatic stellate cells]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050801
[The effect of tetrandrine on the expression of the P170, LRP and TOPO II in S180's tumor cell induced by chemotherapy in the mice with acquired multi-drug resistance]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801
Differential inhibition of rat alpha3* and alpha7 nicotinic acetylcholine receptors by tetrandrine and closely related bis-benzylisoquinoline derivatives. Neuroscience letters 20050624
Tetrandrine inhibits activation of rat hepatic stellate cells in vitro via transforming growth factor-beta signaling. World journal of gastroenterology 20050521
Nonaqueous capillary electrophoresis for rapid and sensitive determination of fangchinoline and tetrandrine in radix Stephaniae tetrandrae and its medicinal preparations. Journal of separation science 20050501
[Study on the stability of tetrandrine microsphere]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050501
Inhibitory effects of Stephania tetrandra S. Moore on free radical-induced lysis of rat red blood cells. Biological & pharmaceutical bulletin 20050401
Reversal of multidrug resistance of cancer through inhibition of P-glycoprotein by 5-bromotetrandrine. Cancer chemotherapy and pharmacology 20050201
[The study of tetrandrine on reversion of P170 and apoptosis of obtained multi-drug resistance of mice S180's tumour cell]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201
[Effect of tetrandrine combined with Droloxifen on the expression of bcr/abl of K562 at both mRNA and protein levels]. Zhongguo shi yan xue ye xue za zhi 20050201
Tetrandrine and thapsigargin release arachidonic acid from cells in culture and stimulate prostacyclin production in rat liver cells, but may do so by different pathways. BMC pharmacology 20050101
In vitro and in vivo characterizations of tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel. Anticancer research 20050101
Electropharmacological actions of the constituents of Sinomeni Caulis et Rhizome and Mokuboi-to in guinea pig heart. The American journal of Chinese medicine 20050101
Tetrandrine, a bisbenzylisoquinoline alkaloid from Chinese herb Radix, augmented the hypnotic effect of pentobarbital through serotonergic system. European journal of pharmacology 20041215
Tetrandrine induces early G1 arrest in human colon carcinoma cells by down-regulating the activity and inducing the degradation of G1-S-specific cyclin-dependent kinases and by inducing p53 and p21Cip1. Cancer research 20041215
Plant alkaloid tetrandrine downregulates IkappaBalpha kinases-IkappaBalpha-NF-kappaB signaling pathway in human peripheral blood T cell. British journal of pharmacology 20041201
Effect of p-glycoprotein inhibitor combinations on drug efflux from rat brain microvessel endothelial cells. Die Pharmazie 20041201
The influence of hypotonicity on large-conductance calcium-activated potassium channels in human retinal pigment epithelial cells. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041201
Increased hepatic expression of nitric oxide synthase type II in cirrhotic rats. World journal of gastroenterology 20040701
Total assignment and structure in solution of tetrandrine by NMR spectroscopy and molecular modelling. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040701
Recognition of alpha-amino acid derivatives by N,N'-dibenzylated S,S-(+)-tetrandrine. Organic & biomolecular chemistry 20040621
Inhibitory effects of tetrandrine on the serum- and platelet-derived growth factor-BB-induced proliferation of rat aortic smooth muscle cells through inhibition of cell cycle progression, DNA synthesis, ERK1/2 activation and c-fos expression. Atherosclerosis 20040601
[Reversal effect of tetrandrine in combination with droloxifene on cell line K562/A02 and its correlation with inducted apoptosis]. Zhongguo shi yan xue ye xue za zhi 20040601
In-vitro metabolism of isotetrandrine, a bisbenzylisoquinoline alkaloid, in rat hepatic S9 fraction by high-performance liquid chromatography-atmospheric pressure ionization mass spectrometry. The Journal of pharmacy and pharmacology 20040601
Effect of pharmacologic preconditioning with tetrandrine on subsequent ischemia/reperfusion injury in rat liver. World journal of surgery 20040601
Tetrandrine-induced apoptosis is mediated by activation of caspases and PKC-delta in U937 cells. Biochemical pharmacology 20040515
The plasma glucose lowering action of tetrandrine in streptozotocin-induced diabetic rats. The Journal of pharmacy and pharmacology 20040501
[Separation and identification of alkaloids in Stephania tetrandra by capillary electrophoresis electrospray-MS/MS]. Yao xue xue bao = Acta pharmaceutica Sinica 20040501
Characterization of tetrandrine, a potent inhibitor of P-glycoprotein-mediated multidrug resistance. Cancer chemotherapy and pharmacology 20040401
[Study on the relationship between [Ca2+]i and the MDR formation in K562/A02 cells]. Zhongguo shi yan xue ye xue za zhi 20040401
Tetrandrine induces apoptosis in hepatic stellate cells. Phytotherapy research : PTR 20040401
[Pharmacokinetics of bromotetrandrin (W198) in rats and beagle dogs]. Yao xue xue bao = Acta pharmaceutica Sinica 20040401
Tetrandrine inhibits Ca2+-activated chloride channel in cultured human umbilical vein endothelial cells. Acta pharmacologica Sinica 20040301
Herbal alkaloid tetrandrine: fron an ion channel blocker to inhibitor of tumor proliferation. Trends in pharmacological sciences 20040301
Effect of Qingyitang on activity of intracellular Ca2+-Mg2+-ATPase in rats with acute pancreatitis. World journal of gastroenterology 20040101
Antihypertensive and anti-arrhythmic effects of an extract of Radix Stephaniae Tetrandrae in the rat. The Journal of pharmacy and pharmacology 20040101
Tetrandrine ameliorates cirrhosis and portal hypertension by inhibiting nitric oxide in cirrhotic rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20040101
Inhibitory effect of tetrandrine on pulmonary metastases in CT26 colorectal adenocarcinoma-bearing BALB/c mice. The American journal of Chinese medicine 20040101
[Therapeutic effect of qingyi decoction and tetrandrine in treating severe acute pancreatitis in miniature pigs and serum drug level determination]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031101
Persistent reversal of P-glycoprotein-mediated daunorubicin resistance by tetrandrine in multidrug-resistant human T lymphoblastoid leukemia MOLT-4 cells. The Journal of pharmacy and pharmacology 20031101
[Effect of tetradrine on electrophysilogic changes caused by rising of left ventricular preload in guinea pigs]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031101
A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 20031030
Induction of apoptosis in human hepatoblastoma cells by tetrandrine via caspase-dependent Bid cleavage and cytochrome c release. Biochemical pharmacology 20030901
[Experimental study on antagonism of tetrandrine in acute renal injury induced by gentamicin in guinea pig]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20030801
Simplified tetrandrine congeners as possible antihypertensive agents with a dual mechanism of action. Journal of natural products 20030701
[The relaxation effects of tetrandrine on the corpus cavernosum tissue of rabbit in vitro]. Zhonghua nan ke xue = National journal of andrology 20030601
Protective effects of fangchinoline and tetrandrine on hydrogen peroxide-induced oxidative neuronal cell damage in cultured rat cerebellar granule cells. Planta medica 20030601
Tetrandrine-induced cell cycle arrest and apoptosis in Hep G2 cells. Life sciences 20030530
[Regression of vascular remodeling in renovascular hypertensive rats by tetrandrine and enalapril]. Yao xue xue bao = Acta pharmaceutica Sinica 20030501
High-affinity binding of [3H]DTZ323 to the diltiazem-binding site of L-type Ca2+ channels. European journal of pharmacology 20030411
Anti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra Radix in streptozotocin-diabetic mice. Biological & pharmaceutical bulletin 20030301
Effects of tetrandrine on calcium and potassium currents in isolated rat hepatocytes. World journal of gastroenterology 20030115
Effects of Tetrandrine and QYT on ICAM-1 and SOD gene expression in pancreas and liver of rats with acute pancreatitis. World journal of gastroenterology 20030115
[Experimental study on effects of endothelin in the proliferation and collagen synthesis of human scar-derived fibroblasts]. Zhonghua zheng xing wai ke za zhi = Zhonghua zhengxing waike zazhi = Chinese journal of plastic surgery 20030101
Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. International journal of oncology 20021201
Tetrandrine potentiates caffeine-induced contraction but inhibits phenylephrine-induced contraction in perfused rat mesenteric artery. Naunyn-Schmiedeberg's archives of pharmacology 20021201
Tetrandrine and related bis-benzylisoquinoline alkaloids from medicinal herbs: cardiovascular effects and mechanisms of action. Acta pharmacologica Sinica 20021201
Effects of tetrandrine on cardiovascular electrophysiologic properties. Acta pharmacologica Sinica 20021201
Effects of tetrandrine on cardiac and vascular remodeling. Acta pharmacologica Sinica 20021201
Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives. Acta pharmacologica Sinica 20021201
Immunomodulatory effects and mechanisms of plant alkaloid tetrandrine in autoimmune diseases. Acta pharmacologica Sinica 20021201
Potential role of tetrandrine in cancer therapy. Acta pharmacologica Sinica 20021201
Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta pharmacologica Sinica 20021201
Effects of tetrandrine on smooth muscle contraction induced by mediators in pulmonary hypertension. Acta pharmacologica Sinica 20021201
Effect of tetrandrine on free intracellular calcium in cultured calf basilar artery smooth muscle cells. Acta pharmacologica Sinica 20021201
Traditional herbal medicine research with special reference to tetrandrine and related bis-benzylisoquinoline alkaloids: a preface to this special issue on herbal drugs. Acta pharmacologica Sinica 20021201
[Effect of tetrandrine and droloxifene on the reversion of drug resistance of K562/A02 cell line and induction of apoptosis]. Zhonghua zhong liu za zhi [Chinese journal of oncology] 20021101
[Determination of tetrandine content in tetrandine microsphere]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20021001
Tetrandrine cytotoxicity and its dual effect on oxidative stress-induced apoptosis through modulating cellular redox states in Neuro 2a mouse neuroblastoma cells. Life sciences 20020913
Effects of the plant alkaloid tetrandrine on human nicotinic acetylcholine receptors. European journal of pharmacology 20020830
Characterization of a novel tetrandrine-induced contraction in rat tail artery. Acta pharmacologica Sinica 20020801
Inhibition of proliferation and induction of apoptosis by tetrandrine in HepG2 cells. Journal of ethnopharmacology 20020701
Effects of various principles from Chinese herbal medicine on rhodamine123 accumulation in brain capillary endothelial cells. Acta pharmacologica Sinica 20020701
Therapeutic efficacy of Stephania tetrandra S. Moore for treatment of neovascularization of retinal capillary (retinopathy) in diabetes--in vitro study. Phytomedicine : international journal of phytotherapy and phytopharmacology 20020701
BK channels in human glioma cells have enhanced calcium sensitivity. Glia 20020601
Crystalline silica incubated in ascorbic acid acquires a higher cytotoxic potential. Toxicology and industrial health 20020601
[An experimental study of inhibition of tetrandrine on posterior capsular opacification in rabbits]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20020401
Stimulatory effects of hyperprolactinemia on aldosterone secretion in ovariectomized rats. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020301
The multidrug resistance of tumour cells was reversed by tetrandrine in vitro and in xenografts derived from human breast adenocarcinoma MCF-7/adr cells. European journal of cancer (Oxford, England : 1990) 20020201
Acute effect of tetrandrine pulmonary targeting microspheres on hypoxic pulmonary hypertension in rats. Chinese medical journal 20020101
[Reversal of anti-apoptotic action by tetrandrine in human breast carcinoma multidrug-resistant MCF-7 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020101
Functional coupling of voltage-dependent L-type Ca2+ current to Ca2+-activated K+ current in pituitary GH3 cells. The Chinese journal of physiology 20011231
Current studies on anti-endotoxic chemical components of traditional Chinese medicine in China. Acta pharmacologica Sinica 20011201
Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions. Molecular pharmacology 20011101
Effect of tetrandrine on neutrophilic recruitment response to brain ischemia/reperfusion. Acta pharmacologica Sinica 20011101
Pharmacology of tetrandrine and its therapeutic use in digestive diseases. World journal of gastroenterology 20011015
Effect of tetrandrine on cellular electrophysiology and calcium uptake of myocardium in guinea pigs and dogs. Chinese medical journal 20011001
Tetrandrine prevents tissue inhibitor of metalloproteinase-1 messenger RNA expression in rat liver fibrosis. Pharmacology & toxicology 20011001
Reciprocal regulation of capacitative and arachidonate-regulated noncapacitative Ca2+ entry pathways. The Journal of biological chemistry 20010921
Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes. The Journal of infectious diseases 20010915
Antagonism of morphine-induced antinociception by tetrandrine is dependent on serotonergic mechanisms. Life sciences 20010810
[Effects of tetrandrine on the synthesis of collagen and scar-derived fibroblast DNA]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20010801
[Progression on studies of treatment of tumor with tetrandrine]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010801
[Depressive effect of tetrandrine on collagen synthesis in vascular smooth muscle cells]. Yao xue xue bao = Acta pharmaceutica Sinica 20010701
Sulfhydryl G proteins and phospholipase A(2)-associated G proteins are involved in adrenergic signal transduction in the rat pineal gland. General and comparative endocrinology 20010601
Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction. Journal of immunology (Baltimore, Md. : 1950) 20010601
Effects of matrine, artemisinin, tetrandrine on cytosolic [Ca2+]i in guinea pig ventricular myocytes. Acta pharmacologica Sinica 20010601
Cardiac effects of the extract and active components of Radix stephaniae tetrandrae. I. Electrically-induced intracellular calcium transient and protein release during the calcium paradox. Life sciences 20010511
Cardiac effects of the extract and active components of radix stephaniae tetrandrae. II. Myocardial infarct, arrhythmias, coronary arterial flow and heart rate in the isolated perfused rat heart. Life sciences 20010511
[Tetrandrine loaded sustained-release microcapsules for lung targeting]. Yao xue xue bao = Acta pharmaceutica Sinica 20010301
[Effect of tetrandrine on expression of bFGF in lung tissue of rat with chronic hypoxic pulmonary hypertension]. Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010301
Inhibitory effect of tetrandrine on dopamine biosynthesis and tyrosine hydroxylase in PC12 cells. Planta medica 20010201
[Effect of the tetrandrine on morphine induced hyperactivity and reinforcement in mice]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010201
[Poteintation of vincristine-induced apoptosis by tetrandrine, neferine and dauricine in the human mammary MCF-7 multidrug-resistant cells]. Yao xue xue bao = Acta pharmaceutica Sinica 20010201
Tetrandrine inhibits Ca2+ release-activated Ca2+ channels in vascular endothelial cells. Life sciences 20010105
Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation. Planta medica 19990301
Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum. Zhongguo yao li xue bao = Acta pharmacologica Sinica 19970701
Studies on the calcium antagonistic action of tetrandrine: XIII. Protective effect of tetrandrine on myocardial hypoxia and necrosis induced by isoproterenol in rats. Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 19860101
Properties