sales@angenesci.com
Login | Register
logo
Structures Search
Home Other Building Blocks (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide

(S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide

CAS No.:
1038915-60-4
Catalog Number:
AG0038ZU
Molecular Formula:
C19H20N4O
Molecular Weight:
320.3883
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$154
- +
10mg
99%
1 week
United States
$196
- +
100mg
99+%
1 week
United States
$202
- +
250mg
99+%
1 week
United States
$403
- +
Product Description
Catalog Number:
AG0038ZU
Chemical Name:
(S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide
CAS Number:
1038915-60-4
Molecular Formula:
C19H20N4O
Molecular Weight:
320.3883
MDL Number:
MFCD17779309
IUPAC Name:
2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
InChI:
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
InChI Key:
PCHKPVIQAHNQLW-CQSZACIVSA-N
SMILES:
NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1
UNII:
HMC2H89N35
Properties
Complexity:
449  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
320.164g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
320.396g/mol
Monoisotopic Mass:
320.164g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
72.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies. Frontiers in oncology 20130101
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors. Cancer research 20121101
PARP inhibitors: its role in treatment of cancer. Chinese journal of cancer 20110701
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. Journal of hematology & oncology 20110101
Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. Journal of medicinal chemistry 20091126
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. The New England journal of medicine 20090709
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 20050414
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 20050414
Properties