Galectin-3 contributes to vascular fibrosis in monocrotaline-induced pulmonary arterial hypertension rat model.

Journal of biochemical and molecular toxicology 20170501

Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway.

Toxicology and applied pharmacology 20160715

Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways.

Acta biochimica et biophysica Sinica 20150301

Inhibition of STAT3 signaling as critical molecular event in resveratrol-suppressed ovarian cancer cells.

Journal of ovarian research 20150101

Development of a novel azaspirane that targets the Janus kinase-signal transducer and activator of transcription (STAT) pathway in hepatocellular carcinoma in vitro and in vivo.

The Journal of biological chemistry 20141205

Upregulation of the large conductance voltage- and Ca2+-activated K+ channels by Janus kinase 2.

American journal of physiology. Cell physiology 20140601

Biological significance and therapeutic implication of resveratrol-inhibited Wnt, Notch and STAT3 signaling in cervical cancer cells.

Genes & cancer 20140501

Developmental defects in zebrafish for classification of EGF pathway inhibitors.

Toxicology and applied pharmacology 20140115

Short-term resveratrol exposure causes in vitro and in vivo growth inhibition and apoptosis of bladder cancer cells.

PloS one 20140101

Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells.

Toxicology and applied pharmacology 20131101

Cooperation of bisphenol A and leptin in inhibition of caspase-3 expression and activity in OVCAR-3 ovarian cancer cells.

Toxicology in vitro : an international journal published in association with BIBRA 20130901

The JAK2/STAT3 and mitochondrial pathways are essential for quercetin nanoliposome-induced C6 glioma cell death.

Cell death & disease 20130801

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

The Biochemical journal 20130415

Pterostilbene exerts antitumor activity against human osteosarcoma cells by inhibiting the JAK2/STAT3 signaling pathway.

Toxicology 20130208

A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.

PloS one 20130101

Prolactin regulates luminal bicarbonate secretion in the intestine of the sea bream (Sparus aurata L.).

The Journal of experimental biology 20121101

Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor.

Journal of clinical immunology 20121001

Ischemic postconditioning during reperfusion attenuates intestinal injury and mucosal cell apoptosis by inhibiting JAK/STAT signaling activation.

Shock (Augusta, Ga.) 20121001

Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20120901

Tyrosine kinase pathways modulate tumor susceptibility to natural killer cells.

The Journal of clinical investigation 20120702

Interleukin 6 protects H(2)O(2)-induced cardiomyocytes injury through upregulation of prohibitin via STAT3 phosphorylation.

Cell biochemistry and function 20120701

A Herpesvirus saimiri-based vector expressing TRAIL induces cell death in human carcinoma cell lines and multicellular spheroid cultures.

International journal of oncology 20120601

Involvement of intracellular oxidative stress-sensitive pathway in phloxine B-induced photocytotoxicity in human T lymphocytic leukemia cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601

JAK/STAT pathway plays a critical role in the proinflammatory gene expression and apoptosis of RAW264.7 cells induced by trichothecenes as DON and T-2 toxin.

Toxicological sciences : an official journal of the Society of Toxicology 20120601

Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells.

Cancer biology & therapy 20120601

Site-specific regulation of ion transport by prolactin in rat colon epithelium.

American journal of physiology. Gastrointestinal and liver physiology 20120515

Regulation of interferon-inducible proteins by doxorubicin via interferon γ-Janus tyrosine kinase-signal transducer and activator of transcription signaling in tumor cells.

Molecular pharmacology 20120501

The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.

Basic research in cardiology 20120501

Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity.

Journal of pineal research 20120401

Up-regulation of the betaine/GABA transporter BGT1 by JAK2.

Biochemical and biophysical research communications 20120330

Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis.

Journal of cellular physiology 20120301

Downregulation of the creatine transporter SLC6A8 by JAK2.

The Journal of membrane biology 20120301

IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis.

Molecular immunology 20120201

The Jak/STAT pathway is involved in synaptic plasticity.

Neuron 20120126

A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.

Toxicology and applied pharmacology 20120115

Prolactin-induced activation of phagocyte NADPH oxidase in the teleost fish gilthead seabream involves the phosphorylation of p47phox by protein kinase C.

Developmental and comparative immunology 20120101

Mutual regulation of growth hormone and bone morphogenetic protein system in steroidogenesis by rat granulosa cells.

Endocrinology 20120101

Primary effusion lymphoma cell death induced by bortezomib and AG 490 activates dendritic cells through CD91.

PloS one 20120101

Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.

PloS one 20120101

The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice.

PloS one 20120101

AG490 promotes HIF-1α accumulation by inhibiting its hydroxylation.

Current medicinal chemistry 20120101

MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Hyperglycaemia exacerbates choroidal neovascularisation in mice via the oxidative stress-induced activation of STAT3 signalling in RPE cells.

PloS one 20120101

STAT1 mediates oroxylin a inhibition of iNOS and pro-inflammatory cytokines expression in microglial BV-2 cells.

PloS one 20120101

Chronic perinatal hypoxia reduces glutamate-aspartate transporter function in astrocytes through the Janus kinase/signal transducer and activator of transcription pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20111207

AG490: an inhibitor of hepcidin expression in vivo.

World journal of gastroenterology 20111207

STAT3 does not regulate acute liver injury after ischemia/reperfusion.

The Journal of surgical research 20111201

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

Cellular signalling 20111201

Transcription suppression of SARI (suppressor of AP-1, regulated by IFN) by BCR-ABL in human leukemia cells.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20111201

Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke.

Stroke 20111201

Phosphorylation of JAK2 by serotonin 5-HT (2A) receptor activates both STAT3 and ERK1/2 pathways and increases growth of JEG-3 human placental choriocarcinoma cell.

Placenta 20111201

Tyrphostin-like compounds with ubiquitin modulatory activity as possible therapeutic agents for multiple myeloma.

Bioorganic & medicinal chemistry 20111201

Mitochondrial STAT3 activation and cardioprotection by ischemic postconditioning in pigs with regional myocardial ischemia/reperfusion.

Circulation research 20111111

The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats.

Cytokine 20111101

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Nature biotechnology 20111101

Human gastrin mRNA expression up-regulated by Helicobacter pylori CagA through MEK/ERK and JAK2-signaling pathways in gastric cancer cells.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20111001

Erythropoietin protects retinal pigment epithelial cells against the increase of permeability induced by diabetic conditions: essential role of JAK2/ PI3K signaling.

Cellular signalling 20111001

Angiotensin II utilizes Janus kinase 2 in hypertension, but not in the physiological control of blood pressure, during low-salt intake.

American journal of physiology. Regulatory, integrative and comparative physiology 20111001

[Effect of homoharringtonine combined with AG490 on JAK2-STAT5 associated signal pathway in HEL cells].

Zhongguo shi yan xue ye xue za zhi 20111001

Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.

Cancer letters 20110901

Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.

American journal of physiology. Cell physiology 20110901

Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway.

International immunopharmacology 20110801

Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-β1 in the pathophysiology of acute pancreatitis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110801

Interferon-gamma-induced MD-2 protein expression and lipopolysaccharide (LPS) responsiveness in corneal epithelial cells is mediated by Janus tyrosine kinase-2 activation and direct binding of STAT1 protein to the MD-2 promoter.

The Journal of biological chemistry 20110708

Activation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of rats.

Neuroscience letters 20110708

Reactive oxygen species scavenger inhibits STAT3 activation after transient focal cerebral ischemia-reperfusion injury in rats.

Anesthesia and analgesia 20110701

Effects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells.

Journal of endodontics 20110601

Stimulation of the glucose carrier SGLT1 by JAK2.

Biochemical and biophysical research communications 20110506

The antagonist of the JAK-1/STAT-1 signaling pathway improves the severity of cerulein-stimulated pancreatic injury via inhibition of NF-κB activity.

International journal of molecular medicine 20110501

Cortex Dictamni extract induces apoptosis of activated hepatic stellate cells via STAT1 and attenuates liver fibrosis in mice.

Journal of ethnopharmacology 20110426

[Effects of blocking activation of IGF-1-Stat3 signaling pathway in guinea pig sclera fibroblast by AG490 on expression of MMP-2 and Integrinβ(1)].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20110401

Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells.

Journal of neuro-oncology 20110201

JAK2 is an important signal transducer in IL-33-induced NF-κB activation.

Cellular signalling 20110201

In vitro leptin treatment of rainbow trout hypothalamus and hindbrain affects glucosensing and gene expression of neuropeptides involved in food intake regulation.

Peptides 20110201

Characterization of squamous esophageal cells resistant to bile acids at acidic pH: implication for Barrett's esophagus pathogenesis.

American journal of physiology. Gastrointestinal and liver physiology 20110201

JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription.

Journal of cellular biochemistry 20110201

Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.

Bioorganic & medicinal chemistry 20110115

α4β2 nicotinic receptors partially mediate anti-inflammatory effects through Janus kinase 2-signal transducer and activator of transcription 3 but not calcium or cAMP signaling.

Molecular pharmacology 20110101

LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease.

Nature cell biology 20110101

Tyrphostin AG490 reduces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice.

Vascular pharmacology 20110101

Rosuvastatin treatment activates JAK-STAT pathway and increases efficacy of allogeneic mesenchymal stem cell transplantation in infarcted hearts.

Circulation journal : official journal of the Japanese Circulation Society 20110101

Postconditioning inhibits myocardial apoptosis during prolonged reperfusion via a JAK2-STAT3-Bcl-2 pathway.

Journal of biomedical science 20110101

Non-nuclear activation of signal transducer and activator of transcription 3 by 17β- estradiol in endometrial cancer cells.

Neoplasma 20110101

Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

PloS one 20110101

p22phox-dependent NADPH oxidase activity is required for megakaryocytic differentiation.

Cell death and differentiation 20101201

Rhizoctonia bataticola lectin (RBL) induces mitogenesis and cytokine production in human PBMC via p38 MAPK and STAT-5 signaling pathways.

Biochimica et biophysica acta 20101201

[The effect of Janus kinase 2 inhibitor AG490 on renal tubular epithelial-myofibroblast transdifferentiation induced by interleukin-1β].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201

[The expression of suppressor of cytokine signaling-1/3 in renal tubular epithelial cells induced by high glucose].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Ethanolamine is a novel STAT-3 dependent cardioprotective agent.

Basic research in cardiology 20101101

Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore.

American journal of physiology. Heart and circulatory physiology 20101001

Differential regulation of proliferation and differentiation in neural precursor cells by the Jak pathway.

Stem cells (Dayton, Ohio) 20101001

Jak/STAT signaling is involved in the inflammatory infiltration of the kidneys in MRL/lpr mice.

Lupus 20100901

Estrogen increases, whereas IL-27 and IFN-gamma decrease, splenocyte IL-17 production in WT mice.

European journal of immunology 20100901

Blockade of Janus kinase 2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100901

Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling.

Molecular and cellular endocrinology 20100830

JAK2V617F/STAT5 signaling pathway promotes cell proliferation through activation of Pituitary Tumor Transforming Gene 1 expression.

Biochemical and biophysical research communications 20100806

Frequent STAT3 activation is associated with Mcl-1 expression in nasal NK-cell lymphoma.

International journal of laboratory hematology 20100801

JAK2 inhibition prevents innate immune responses and rescues animals from sepsis.

Journal of molecular medicine (Berlin, Germany) 20100801

JAK2 V617F uses distinct signalling pathways to induce cell proliferation and neutrophil activation.

British journal of haematology 20100801

Activation of the JAK-STAT pathway by olanzapine is necessary for desensitization of serotonin2A receptor-stimulated phospholipase C signaling in rat frontal cortex but not serotonin2A receptor-stimulated hormone release.

Journal of psychopharmacology (Oxford, England) 20100701

Antagonists of growth hormone-releasing hormone inhibit the proliferation of human benign prostatic hyperplasia cells.

The Prostate 20100701

[Helicobacter pylori cytotoxin associated protein CagA regulates gastrin gene promoter activity].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20100701

Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.

Toxicology in vitro : an international journal published in association with BIBRA 20100601

Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.

Toxicological sciences : an official journal of the Society of Toxicology 20100501

An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning.

Experimental physiology 20100501

Molecular mechanisms of cellular proliferation in acute myelogenous leukemia by leptin.

Oncology reports 20100501

Blockade of Janus kinase-2 signaling ameliorates mouse liver damage due to ischemia and reperfusion.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20100501

Cinnamaldehyde impairs high glucose-induced hypertrophy in renal interstitial fibroblasts.

Toxicology and applied pharmacology 20100415

A receptor-independent, cell-based JAK activation assay for screening for JAK3-specific inhibitors.

Journal of immunological methods 20100331

Intermediate Ca2+-sensitive K+ channels are necessary for prolactin-induced proliferation in breast cancer cells.

The Journal of membrane biology 20100301

[Inhibitor of tyrosine phosphorylation AG490 inhibits the proliferation of Jurkat T cells].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100301

Effects of AG490 on lens epithelial cell death induced by H(2)O(2).

Japanese journal of ophthalmology 20100301

STAT5-glucocorticoid receptor interaction and MTF-1 regulate the expression of ZnT2 (Slc30a2) in pancreatic acinar cells.

Proceedings of the National Academy of Sciences of the United States of America 20100216

Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin.

Cancer letters 20100201

Leptin excites proopiomelanocortin neurons via activation of TRPC channels.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100127

Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes.

Regulatory peptides 20100108

IL-23 induces receptor activator of NF-kappaB ligand expression in fibroblast-like synoviocytes via STAT3 and NF-kappaB signal pathways.

Immunology letters 20100104

Aberrant expression of serum amyloid A in head and neck squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100101

The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.

The American journal of pathology 20100101

Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro.

PloS one 20100101

Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro.

Journal of experimental & clinical cancer research : CR 20100101

Inhibition of the signal transducers and activators of transcription (STAT) 3 signalling pathway by AG490 in laryngeal carcinoma cells.

The Journal of international medical research 20100101

Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells.

Biochemical and biophysical research communications 20091218

Synergistic effect of radiation and interleukin-6 on hepatitis B virus reactivation in liver through STAT3 signaling pathway.

International journal of radiation oncology, biology, physics 20091201

Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis.

The Journal of biological chemistry 20091127

STAT1/2 is involved in the inhibition of cell growth induced by U0126 in HeLa cells.

Cellular and molecular biology (Noisy-le-Grand, France) 20091115

Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway.

Journal of ethnopharmacology 20091112

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway.

Cardiovascular research 20091101

Histamine induces human beta-defensin-3 production in human keratinocytes.

Journal of dermatological science 20091101

IL-6 regulates MMP-10 expression via JAK2/STAT3 signaling pathway in a human lung adenocarcinoma cell line.

Anticancer research 20091101

NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.

Toxicology and applied pharmacology 20091015

Stat3 is involved in angiotensin II-induced expression of MMP2 in gastric cancer cells.

Digestive diseases and sciences 20091001

Involvement of JAK-STAT signaling/function after cyclophosphamide-induced bladder inflammation in female rats.

American journal of physiology. Renal physiology 20091001

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome-proliferator-activated receptor gamma (PPARgamma).

Biology of the cell 20090923

17-hydroxy-jolkinolide B inhibits signal transducers and activators of transcription 3 signaling by covalently cross-linking Janus kinases and induces apoptosis of human cancer cells.

Cancer research 20090915

Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3.

Cell research 20090901

Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages.

Immunology 20090901

Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach.

Journal of medicinal chemistry 20090827

Prolactin induces chitotriosidase expression in human macrophages through PTK, PI3-K, and MAPK pathways.

Journal of cellular biochemistry 20090801

Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cells.

American journal of physiology. Cell physiology 20090801

Serenoa repens induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of STAT 3 signaling.

Oncology reports 20090801

The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model.

Investigative ophthalmology & visual science 20090701

The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice.

International immunopharmacology 20090701

[Role of angiotensin II and JAK2 signal pathway in transdifferentation of renal tubular cells in mice after acute ischemic followed by reperfusion].

Zhonghua bing li xue za zhi = Chinese journal of pathology 20090701

Alternative implication of CXCR4 in JAK2/STAT3 activation in small cell lung cancer.

British journal of cancer 20090616

Activation of the JAK-STAT pathway is necessary for desensitization of 5-HT2A receptor-stimulated phospholipase C signalling by olanzapine, clozapine and MDL 100907.

The international journal of neuropsychopharmacology 20090601

Absence of STAT1 disturbs the anticancer effect induced by STAT3 inhibition in head and neck carcinoma cell lines.

International journal of molecular medicine 20090601

Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527

Ozone stress down-regulates the expression of cystic fibrosis transmembrane conductance regulator in human bronchial epithelial cells.

Chemico-biological interactions 20090515

The acute lymphoblastic leukemia-associated JAK2 L611S mutant induces tumorigenesis in nude mice.

The Journal of biological chemistry 20090508

Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1.

Investigative ophthalmology & visual science 20090501

A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes.

Biochemical and biophysical research communications 20090501

STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria.

Molecular immunology 20090501

Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: an implication for the pathogenesis of arthritis.

Arthritis and rheumatism 20090501

Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090501

Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients.

Oncogene 20090409

IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner.

Atherosclerosis 20090401

Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.

Journal of molecular endocrinology 20090401

STAT3 induces muscle stem cell differentiation by interaction with myoD.

Cytokine 20090401

Myricetin directly targets JAK1 to inhibit cell transformation.

Cancer letters 20090308

Proviral integration site for Moloney murine leukemia virus 1, but not phosphatidylinositol-3 kinase, is essential in the antiapoptotic signaling cascade initiated by IL-5 in eosinophils.

The Journal of allergy and clinical immunology 20090301

Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality.

The Journal of trauma 20090301

Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: central role for JAK2 activation of STAT3 and NF-kappaB.

Brain research 20090223

Inhibition of JAK2 protects renal endothelial and epithelial cells from oxidative stress and cyclosporin A toxicity.

Kidney international 20090101

IL-12-dependent activation of ERK1/2 in human T lymphoblasts.

Immunobiology 20090101

Effects of a JAK inhibitor, AG490, on proliferation and apoptosis of human nasopharyngeal carcinoma cell line CNE-2Z.

Ai zheng = Aizheng = Chinese journal of cancer 20090101

Oxidative stress induces PKR-dependent apoptosis via IFN-gamma activation signaling in Jurkat T cells.

Biochemical and biophysical research communications 20081219

Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors.

Biochemical and biophysical research communications 20081212

Interferon-sensitive response element (ISRE) is mainly responsible for IFN-alpha-induced upregulation of programmed death-1 (PD-1) in macrophages.

Biochimica et biophysica acta 20081201

AG490, a Jak2-specific inhibitor, induces osteoclast survival by activating the Akt and ERK signaling pathways.

Molecules and cells 20081130

JAK2-STAT3 signaling pathway mediates thrombin-induced proinflammatory actions of microglia in vitro.

Journal of neuroimmunology 20081115

Tyrphostin AG-490 inhibited the acute phase of zymosan-induced inflammation.

International immunopharmacology 20081101

Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of Stat3 function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20081101

High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response.

Obesity (Silver Spring, Md.) 20081101

[Neuroprotective effects of combined application of JAK-STAT signal pathway inhibitor and free radical scavenger on focal cerebral ischemia/reperfusion injury in rats].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20081101

Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3.

Molecular cancer research : MCR 20081101

Cloning and characterization of 5'-untranslated region of porcine beta casein gene (CSN2).

Domestic animal endocrinology 20081001

Homoharringtonine affects the JAK2-STAT5 signal pathway through alteration of protein tyrosine kinase phosphorylation in acute myeloid leukemia cells.

European journal of haematology 20081001

Neuroprotective properties of ciliary neurotrophic factor for cultured adult rat dorsal root ganglion neurons.

Histochemistry and cell biology 20081001

Regulating RISK: a role for JAK-STAT signaling in postconditioning?

American journal of physiology. Heart and circulatory physiology 20081001

A potent anti-carcinoma and anti-acute myeloblastic leukemia agent, AG490.

Anti-cancer agents in medicinal chemistry 20081001

Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion.

Basic research in cardiology 20080901

Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.

Toxicological sciences : an official journal of the Society of Toxicology 20080801

[Simvastatin attenuated cardiac hypertrophy via inhibiting JAK-STAT pathways].

Zhonghua xin xue guan bing za zhi 20080801

Inhibition of the signal transducer and activator of transcription-3 (STAT3) signaling pathway by 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid esters.

Journal of medicinal chemistry 20080724

Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity.

Journal of immunology (Baltimore, Md. : 1950) 20080715

Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioning.

Cardiovascular research 20080701

Epithelial sodium channel is a key mediator of growth hormone-induced sodium retention in acromegaly.

Endocrinology 20080701

The role of eNOS, iNOS, and NF-kappaB in upregulation and activation of cyclooxygenase-2 and infarct size reduction by atorvastatin.

American journal of physiology. Heart and circulatory physiology 20080701

Enhanced resistance against systemic Candida albicans infection in mice treated with C. albicans DNA.

FEMS immunology and medical microbiology 20080701

Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells.

Neoplasia (New York, N.Y.) 20080701

Potential role of JAK2 in cerebral vasospasm after experimental subarachnoid hemorrhage.

Brain research 20080612

Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury.

The American journal of cardiology 20080602

Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury.

American journal of physiology. Renal physiology 20080601

[Interferon-alpha upregulates thymidine phosphorylase expression via JAK-STAT transcriptional activation and mRNA stabilization in human hepatocellular carcinoma SMMC-7721 cells].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080601

Simvastatin prevents cardiac hypertrophy in vitro and in vivo via JAK/STAT pathway.

Life sciences 20080507

Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501

Granulocyte colony-stimulating factor prevents reperfusion injury after heart preservation.

The Annals of thoracic surgery 20080401

Possible involvement of prolactin in the synthesis of lactoferrin in bovine mammary epithelial cells.

Bioscience, biotechnology, and biochemistry 20080401

Transcriptional activity of the DeltaNp63 promoter is regulated by STAT3.

The Journal of biological chemistry 20080321

Mao (Ephedra sinica Stapf) protects against D-galactosamine and lipopolysaccharide-induced hepatic failure.

Cytokine 20080301

The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines.

Cancer investigation 20080301

Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells.

Neoplasia (New York, N.Y.) 20080301

Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas.

Blood 20080201

Orazipone inhibits activation of inflammatory transcription factors nuclear factor-kappa B and signal transducer and activator of transcription 1 and decreases inducible nitric-oxide synthase expression and nitric oxide production in response to inflammatory stimuli.

The Journal of pharmacology and experimental therapeutics 20080201

[Effects of Yisui Jiedu Recipe on JAK2-STAT5 signal transduction pathway in bone marrow hematopoietic cells from patients with myelodysplastic syndrome-refractory anemia].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080201

Prolactin and growth hormone induce differential cytokine and chemokine profile in murine peritoneal macrophages in vitro: involvement of p-38 MAP kinase, STAT3 and NF-kappaB.

Cytokine 20080201

Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.

The Journal of biological chemistry 20080118

Blockage of JAK/STAT signalling attenuates renal ischaemia-reperfusion injury in rat.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080101

Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart.

American journal of physiology. Heart and circulatory physiology 20080101

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells.

The international journal of biochemistry & cell biology 20080101

[The molecular mechanism of survivin expression in activated human peripheral lymphocytes].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20080101

[Effect of Janus kinase inhibitor AG490 on invasion and metastasis of human breast cancer cells].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080101

Postreceptor crosstalk on PI3K/Akt between GH and insulin in non-catch-up growth rats born small for gestational age.

Hormone research 20080101

Effect of Jak2 kinase inhibition on Stat1 and Stat3 activation and apoptosis of tubular epithelial cells induced by ATP depletion/recovery.

Journal of nephrology 20080101

Inhibition of Stat3 increases doxorubicin sensitivity in a human metastatic breast cancer cell line.

Cancer letters 20071218

A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Proceedings of the National Academy of Sciences of the United States of America 20071218

WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells.

Cancer research 20071201

Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells.

Biochemical and biophysical research communications 20071123

Jak2 dampens the induction by IL-1beta of prostaglandin endoperoxide H synthase 2 expression in human orbital fibroblasts: evidence for divergent influence on the prostaglandin E2 biosynthetic pathway.

Journal of immunology (Baltimore, Md. : 1950) 20071115

AG490 influences UCN-01-induced cytotoxicity in glioma cells in a p53-dependent fashion, correlating with effects on BAX cleavage and BAD phosphorylation.

Cancer letters 20071108

JAK/STAT pathway mediates retinal ganglion cell survival after acute ocular hypertension but not under normal conditions.

Experimental eye research 20071101

S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase.

The Journal of biological chemistry 20071019

Modulation of mast cell proteinase-activated receptor expression and IL-4 release by IL-12.

Immunology and cell biology 20071001

Abrogation of constitutive STAT3 activity sensitizes human hepatoma cells to TRAIL-mediated apoptosis.

Journal of hepatology 20071001

Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490.

Glia 20071001

Angiotensin-(1 7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors.

American journal of physiology. Heart and circulatory physiology 20070801

Direct effects of prolactin on adrenal steroid release in male Hatano high-avoidance (HAA) rats may be mediated through Janus kinase 2 (Jak2) activity.

The Journal of reproduction and development 20070801

Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation.

American journal of physiology. Heart and circulatory physiology 20070801

PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.

The European journal of neuroscience 20070801

Olanzapine increases RGS7 protein expression via stimulation of the Janus tyrosine kinase-signal transducer and activator of transcription signaling cascade.

The Journal of pharmacology and experimental therapeutics 20070701

Autocrine prolactin promotes prostate cancer cell growth via Janus kinase-2-signal transducer and activator of transcription-5a/b signaling pathway.

Endocrinology 20070701

Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.

Journal of cardiovascular pharmacology 20070701

Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation.

Cancer research 20070601

Molecular mechanisms involved in interleukin-4-induced human neutrophils: expression and regulation of suppressor of cytokine signaling.

Journal of leukocyte biology 20070501

Raloxifene plus 17beta-estradiol inhibits proliferation of primary cultured vascular smooth muscle cells and human mammary endothelial cells via the janus kinase/signal transducer and activator of transcription3 cascade.

European journal of pharmacology 20070430

A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo.

Oncogene 20070412

GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals.

Biogerontology 20070401

JAK kinases control IL-5 receptor ubiquitination, degradation, and internalization.

Journal of leukocyte biology 20070401

Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.

American journal of physiology. Cell physiology 20070301

Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons.

Experimental neurology 20070301

Growth hormone stimulates osteoprotegerin expression and secretion in human osteoblast-like cells.

The Journal of endocrinology 20070301

Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth.

The Journal of biological chemistry 20070209

Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells.

Journal of hepatology 20070101

Constitutive phosphorylation of Janus kinase 2 in the GL15 glioblastoma derived human cell line.

Oncology reports 20070101

Roles of mTOR and STAT3 in autophagy induced by telomere 3' overhang-specific DNA oligonucleotides.

Autophagy 20070101

Modulation of protein tyrosine phosphatase 1B by erythropoietin in UT-7 cell line.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

Inhibition of Jak/STAT signaling ameliorates mice experimental nephrotic syndrome.

American journal of nephrology 20070101

Neural differentiation potentiated by the leukaemia inhibitory factor through STAT3 signalling in mouse embryonal carcinoma cells.

Folia biologica 20070101

Inhibition of Jak2 phosphorylation attenuates pressure overload cardiac hypertrophy.

Vascular pharmacology 20061201

Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro.

Cancer science 20061201

[Inhibitory effect of AG490 on invasion and metastasis of human pancreatic cancer cells in vitro].

Zhonghua zhong liu za zhi [Chinese journal of oncology] 20061201

Suppression of IL-1beta expression by the Jak 2 inhibitor AG490 in cerulein-stimulated pancreatic acinar cells.

Biochemical pharmacology 20061130

Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20061101

Metallothionein mediates cardioprotection of isoliquiritigenin against ischemia-reperfusion through JAK2/STAT3 activation.

Acta pharmacologica Sinica 20061101

Cardiotrophin-1 induces interleukin-6 synthesis in human umbilical vein endothelial cells.

Cytokine 20061101

Role of signal transducer and activator of transcription 3 (STAT3) in stretch injury to bladder smooth muscle cells.

Cell and tissue research 20061001

Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

Biology of reproduction 20061001

Pyridone 6, a pan-Janus-activated kinase inhibitor, induces growth inhibition of multiple myeloma cells.

Cancer research 20061001

[Effects of a JAK inhibitor, AG490, on proliferation and survivin expression of breast cancer cell line MDA-MB-231].

Ai zheng = Aizheng = Chinese journal of cancer 20061001

Targeting constitutive and interleukin-6-inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane).

International journal of cancer 20060915

Involvement of JAK2 and Src kinase tyrosine phosphorylation in human growth hormone-stimulated increases in cytosolic free Ca2+ and insulin secretion.

American journal of physiology. Cell physiology 20060901

All-trans retinoic acid stimulates IL-2-mediated proliferation of human T lymphocytes: early induction of cyclin D3.

Journal of immunology (Baltimore, Md. : 1950) 20060901

JAK2 and STAT3 activation contributes to neuronal damage following transient focal cerebral ischemia.

Journal of neurochemistry 20060901

STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.

Kidney international 20060801

Interferon-gamma enhances superoxide production in human mesangial cells via the JAK-STAT pathway.

Kidney international 20060801

Interleukin (IL)-4 and IL-13 up-regulate monocyte chemoattractant protein-1 expression in human bronchial epithelial cells: involvement of p38 mitogen-activated protein kinase, extracellular signal-regulated kinase 1/2 and Janus kinase-2 but not c-Jun NH2-terminal kinase 1/2 signalling pathways.

Clinical and experimental immunology 20060701

Janus kinase 2: a critical target in chronic myelogenous leukemia.

Cancer research 20060701

STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.

Biochemical pharmacology 20060628

American Association for Cancer Research--97th annual meeting.

IDrugs : the investigational drugs journal 20060601

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Constitutive activation of STAT proteins in the HDLM-2 and L540 Hodgkin lymphoma-derived cell lines supports cell survival.

Cellular signalling 20060401

CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2.

Cellular signalling 20060401

Specific function of STAT3, SOCS1, and SOCS3 in the regulation of proliferation and survival of classical Hodgkin lymphoma cells.

International journal of cancer 20060315

Pancreatitis-associated protein I suppresses NF-kappa B activation through a JAK/STAT-mediated mechanism in epithelial cells.

Journal of immunology (Baltimore, Md. : 1950) 20060315

Signal transducers and activators of transcription 3 activation is involved in nuclear accumulation of beta-catenin in colorectal cancer.

Cancer research 20060315

Glycine-extended gastrin inhibits apoptosis in colon cancer cells via separate activation of Akt and JNK pathways.

Molecular and cellular endocrinology 20060309

Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1beta and IL-6 production.

Molecular pharmacology 20060301

Simvastatin attenuates hypertrophic responses induced by cardiotrophin-1 via JAK-STAT pathway in cultured cardiomyocytes.

Molecular and cellular biochemistry 20060301

Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes.

Cardiovascular research 20060215

Interferon regulatory factor-1 is prerequisite to the constitutive expression and IFN-gamma-induced upregulation of B7-H1 (CD274).

FEBS letters 20060206

Activation of JAK/STAT signalling in neurons following spinal cord injury in mice.

Journal of neurochemistry 20060201

Signal transducer and activator of transcription 6 down-regulates toll-like receptor-4 expression of a monocytic cell line.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20060201

Suppression of IL-6 production and proliferation by blocking STAT3 activation in malignant soft tissue tumor cells.

Cancer letters 20060118

The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages.

Journal of molecular medicine (Berlin, Germany) 20060101

Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060101

Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.

Molecular cancer therapeutics 20060101

Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells.

Retrovirology 20060101

The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells.

Anticancer research 20060101

Induction of interleukin-8 secretion and activation of ERK1/2, p38 MAPK signaling pathways by thrombin in dermal fibroblasts.

The international journal of biochemistry & cell biology 20060101

JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages.

Mediators of inflammation 20060101

TRAIL expression up-regulated by interferon-gamma via phosphorylation of STAT1 induces myeloma cell death.

Anticancer research 20060101

LIF upregulates expression of NK-1R in NHBE cells.

Mediators of inflammation 20060101

Leptin potentiates ADP-induced [Ca(2+)](i) increase via JAK2 and tyrosine kinases in a megakaryoblast cell line.

Diabetes research and clinical practice 20051201

STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.

The Biochemical journal 20051201

Prolactin specifically activates signal transducer and activator of transcription 5b in neuroendocrine dopaminergic neurons.

Endocrinology 20051201

Divergent action of calcium channel blockers on ATP-binding cassette protein expression.

Journal of cardiovascular pharmacology 20051201

Jak2 tyrosine kinase prevents angiotensin II-mediated inositol 1,4,5 trisphosphate receptor degradation.

Vascular pharmacology 20051101

Evidence that embryonic neurons regulate the onset of cortical gliogenesis via cardiotrophin-1.

Neuron 20051020

Intracellular pathways triggered by the selective FLT-1-agonist placental growth factor in vascular smooth muscle cells exposed to hypoxia.

British journal of pharmacology 20051001

Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells.

The American journal of pathology 20051001

Prevention of acute lung allograft rejection in rat by the janus kinase 3 inhibitor, tyrphostin AG490.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051001

A VEGF/JAK2/STAT5 axis may partially mediate endothelial cell tolerance to hypoxia.

The Biochemical journal 20050901

Aldosterone induces angiotensin converting enzyme gene expression via a JAK2-dependent pathway in rat endothelial cells.

Endocrinology 20050901

The effects of interleukin-7 on the lymphangiogenic properties of human endothelial cells.

International journal of oncology 20050901

Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons.

Brain : a journal of neurology 20050701

Type I and type II interferons delay human neutrophil apoptosis via activation of STAT3 and up-regulation of cellular inhibitor of apoptosis 2.

Journal of leukocyte biology 20050701

Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.

The Journal of biological chemistry 20050701

Combinatorial approach to identification of tyrphostin inhibitors of cytokine signaling.

Bioorganic & medicinal chemistry 20050701

Targeting Stat3 in cancer therapy.

Anti-cancer drugs 20050701

JAK-STAT signaling pathway in pulmonary arterial smooth muscle cells is activated by hypoxia.

Cell biology international 20050701

Erythropoietin-mediated activation of JAK-STAT signaling contributes to cellular invasion in head and neck squamous cell carcinoma.

Oncogene 20050623

Requirement of multiple signaling pathways for the augmented production of hyaluronan by v-Src.

Nagoya journal of medical science 20050601

Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cells.

Journal of neuro-oncology 20050501

Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20050501

Inflammatory cytokines interleukin-6 and oncostatin m induce plasminogen activator inhibitor-1 in human adipose tissue.

Circulation 20050419

IFNgamma and TNFalpha synergistically induce neurite outgrowth on PC12 cells.

Neuroscience letters 20050411

JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells.

Journal of cellular physiology 20050401

Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells.

Biochemical and biophysical research communications 20050401

Caffeic acid inhibits vascular smooth muscle cell proliferation induced by angiotensin II in stroke-prone spontaneously hypertensive rats.

Hypertension research : official journal of the Japanese Society of Hypertension 20050401

KSHV-GPCR and CXCR2 transforming capacity and angiogenic responses are mediated through a JAK2-STAT3-dependent pathway.

Oncogene 20050317

Stat5 mediates the IL-7-induced accessibility of a representative D-Distal VH gene.

Journal of immunology (Baltimore, Md. : 1950) 20050315

Augmentation of differentiation and gap junction function by kaempferol in partially differentiated colon cancer cells.

Carcinogenesis 20050301

Role of the STAT1 pathway in apoptosis induced by fludarabine and JAK kinase inhibitors in B-cell chronic lymphocytic leukemia.

Leukemia & lymphoma 20050301

Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.

Circulation research 20050204

AG490 prevents cell death after exposure of rat astrocytes to hydrogen peroxide or proinflammatory cytokines: involvement of the Jak2/STAT pathway.

Journal of neurochemistry 20050201

[Mechanisms of increased survival rate by administration of AG490 in rats following extensive liver resection].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20050201

Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells.

Molecular cancer 20050101

[Influence on the cytokines expression on hepatic tissue by inhibition the signal pathway of inflammatory mediators following extensive hepatectomy in rats].

Zhonghua wai ke za zhi [Chinese journal of surgery] 20050101

EGFR-induced cell migration is mediated predominantly by the JAK-STAT pathway in primary esophageal keratinocytes.

American journal of physiology. Gastrointestinal and liver physiology 20041201

Angiotensin II stimulates Pax-2 in rat kidney proximal tubular cells: impact on proliferation and apoptosis.

Kidney international 20041201

Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20041201

Erythropoietin induces cancer cell resistance to ionizing radiation and to cisplatin.

Molecular cancer therapeutics 20041201

Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

Blood 20041115

Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.

Journal of immunology (Baltimore, Md. : 1950) 20041115

STAT3 induces anti-hepatitis C viral activity in liver cells.

Biochemical and biophysical research communications 20041112

The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells.

European journal of immunology 20041101

Janus kinase 2 signaling in the angiotensin II-dependent activation of StAR expression.

Endocrine research 20041101

The androgen receptor co-activator CBP is up-regulated following androgen withdrawal and is highly expressed in advanced prostate cancer.

The Journal of pathology 20041001

STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-alpha-induced epithelial gene expression.

The Journal of biological chemistry 20040820

Jak2 tyrosine kinase mediates oxidative stress-induced apoptosis in vascular smooth muscle cells.

The Journal of biological chemistry 20040813

CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.

FEBS letters 20040716

Angiotensin II increases Pax-2 expression in fetal kidney cells via the AT2 receptor.

Journal of the American Society of Nephrology : JASN 20040601

Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction.

The Biochemical journal 20040515

Phosphatidylinositol-3 kinase inhibitors reproduce the selective antiproliferative effects of imatinib on chronic myeloid leukaemia progenitor cells.

British journal of haematology 20040501

FVIIa:TF induces cell survival via G12/G13-dependent Jak/STAT activation and BclXL production.

Circulation research 20040430

Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli.

American journal of physiology. Renal physiology 20040401

The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase.

The Journal of pharmacology and experimental therapeutics 20040401

Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.

Molecular cancer therapeutics 20040401

Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.

Life sciences 20040312

Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors.

Investigative ophthalmology & visual science 20040301

The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.

The Journal of endocrinology 20040301

Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol.

The Journal of biological chemistry 20040227

Interleukin-6 is a positive regulator of tumor necrosis factor alpha-induced adipose-related protein in 3T3-L1 adipocytes.

FEBS letters 20040227

IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.

Biochemical and biophysical research communications 20040206

AG490 inhibits G1-S traverse in BALB/c-3T3 cells following either mitogenic stimulation or exogenous expression of E2F-1.

Molecular cancer therapeutics 20040201

Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia.

Glia 20040115

Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer: Direct STAT3 inhibition induces apoptosis in prostate cancer lines.

Molecular cancer therapeutics 20040101

Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells.

American journal of nephrology 20040101

Janus kinase 2 and calcium are required for angiotensin II-dependent activation of steroidogenic acute regulatory protein transcription in H295R human adrenocortical cells.

The Journal of biological chemistry 20031226

Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.

British journal of haematology 20031201

Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways.

Cardiovascular research 20031101

Prevention of organ allograft rejection by a specific Janus kinase 3 inhibitor.

Science (New York, N.Y.) 20031031

PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production.

Biochemical and biophysical research communications 20031024

Receptor-guided alignment-based comparative 3D-QSAR studies of benzylidene malonitrile tyrphostins as EGFR and HER-2 kinase inhibitors.

Journal of medicinal chemistry 20031023

Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells.

Journal of immunology (Baltimore, Md. : 1950) 20031001

Insulin resistance induces hyperleptinemia, cardiac contractile dysfunction but not cardiac leptin resistance in ventricular myocytes.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20031001

A critical role for Stat3 signaling in immune tolerance.

Immunity 20030901

Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF.

International archives of allergy and immunology 20030901

Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma.

Oncogene 20030821

Interferon gamma stimulates beta-secretase expression and sAPPbeta production in astrocytes.

Biochemical and biophysical research communications 20030808

Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia.

Blood 20030715

Inhibition of IFN-gamma-mediated inducible nitric oxide synthase induction by the peroxisome proliferator-activated receptor gamma agonist, 15-deoxy-delta 12,14-prostaglandin J2, involves inhibition of the upstream Janus kinase/STAT1 signaling pathway.

Journal of immunology (Baltimore, Md. : 1950) 20030715

Interferon-gamma stimulates the expression of the inducible cAMP early repressor in macrophages through the activation of casein kinase 2. A potentially novel pathway for interferon-gamma-mediated inhibition of gene transcription.

The Journal of biological chemistry 20030516

Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.

Hypertension (Dallas, Tex. : 1979) 20030501

Inhibitors that target protein kinases for the treatment of ovarian carcinoma.

American journal of obstetrics and gynecology 20030501

Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.

Experimental hematology 20030401

Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells.

The Journal of biological chemistry 20030314

Local insulin-like growth factor-II mediates prolactin-induced mammary gland development.

Molecular endocrinology (Baltimore, Md.) 20030301

[Role of Janus kinase/signal transducer and activator of transcription pathway in mediating mRNA expression of high mobility group box1 protein in the liver in septic rats].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20030301

Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.

Blood 20030215

Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colony-stimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia.

Blood 20030201

CCR7-mediated physiological lymphocyte homing involves activation of a tyrosine kinase pathway.

Blood 20030101

Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

Clinical cancer research : an official journal of the American Association for Cancer Research 20030101

Analysis of signal transducer and activator of transcription 3 (STAT3) in gastrointestinal stromal tumors.

Anticancer research 20030101

Gamma interferon-induced nitric oxide production in mouse CD5+ B1-like cell line and its association with apoptotic cell death.

Microbiology and immunology 20030101

Inhibition of constitutively active Stat3 suppresses proliferation and induces apoptosis in glioblastoma multiforme cells.

Oncogene 20021205

Inhibition of the Jak/STAT signaling pathway prevents the high glucose-induced increase in tgf-beta and fibronectin synthesis in mesangial cells.

Diabetes 20021201

Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor.

Molecular endocrinology (Baltimore, Md.) 20021201

Janus kinase 2, an early target of alpha 7 nicotinic acetylcholine receptor-mediated neuroprotection against Abeta-(1-42) amyloid.

The Journal of biological chemistry 20021122

Resistance to chemotherapy via Stat3-dependent overexpression of Bcl-2 in metastatic breast cancer cells.

Oncogene 20021031

JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells.

The Journal of biological chemistry 20021025

Jak2 is involved in c-Myc induction by Bcr-Abl.

Oncogene 20021017

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

American journal of respiratory cell and molecular biology 20020901

Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.

Molecular cancer therapeutics 20020901

IL-12 plays a significant role in the apoptosis of human T cells in the absence of antigenic stimulation.

Cytokine 20020807

Multiple signaling pathways mediate LIF-induced skeletal muscle satellite cell proliferation.

American journal of physiology. Cell physiology 20020701

Regulation of c-myc stability by selective stress conditions and by MEKK1 requires aa 127-189 of c-myc.

Oncogene 20020627

Leukemia inhibitory factor relaxes arteries through endothelium-dependent mechanism.

Biochemical and biophysical research communications 20020607

Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.

The Journal of biological chemistry 20020517

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Leukemia inhibitory factor enhances bFGF-induced IL-6 synthesis in osteoblasts: involvement of JAK2/STAT3.

Cellular signalling 20020401

IL-6 induces expression of the Fli-1 proto-oncogene via STAT3.

Biochemical and biophysical research communications 20020322

Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists.

European journal of pharmacology 20020308

Distinct region of the granulocyte colony-stimulating factor receptor mediates proliferative signaling through activation of Janus kinase 2 and p44/42 mitogen-activated protein kinase.

Cellular signalling 20020301

STAT3, but not ERKs, mediates the IL-6-induced proliferation of renal cancer cells, ACHN and 769P.

Kidney international 20020301

Acute stimulation of glucose uptake by leptin in l6 muscle cells.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020301

Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation.

Journal of immunology (Baltimore, Md. : 1950) 20020215

Role of mitogen-activated protein kinases and tyrosine kinases on IL-1-Induced NF-kappaB activation and iNOS expression in bovine articular chondrocytes.

Nitric oxide : biology and chemistry 20020201

Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression.

European journal of biochemistry 20020201

Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway.

Hypertension (Dallas, Tex. : 1979) 20020101

Effects of combinations of therapeutic agents on the proliferation of progenitor cells in chronic myeloid leukaemia.

British journal of haematology 20020101

[Inhibition of constitutively activated Jak3 and induction of apoptosis in NALM-6 cell line].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20020101

Neuroprotective effects of leptin in vivo and in vitro.

Neuroreport 20011221

Activation of JAK2 by the oxidative stress generated with oxidized low-density lipoprotein.

Free radical biology & medicine 20011201

Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells.

British journal of pharmacology 20011201

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) modulates lactogenic hormone-mediated differentiation and gene expression in HC11 mouse mammary epithelial cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20011201

Inhibition of JAK kinase activity enhances Fas-mediated apoptosis but reduces cytotoxic activity of topoisomerase II inhibitors in U266 myeloma cells.

Clinical cancer research : an official journal of the American Association for Cancer Research 20011201

Inhibition of constitutively active Stat3 suppresses growth of human ovarian and breast cancer cells.

Oncogene 20011129

HTLV-1 cell lines differ in constitutively activated signaling pathways that can be altered by cytokine exposure.

Virology 20011110

The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome.

Leukemia 20011101

PRL-induced ERalpha gene expression is mediated by Janus kinase 2 (Jak2) while signal transducer and activator of transcription 5b (Stat5b) phosphorylation involves Jak2 and a second tyrosine kinase.

Molecular endocrinology (Baltimore, Md.) 20011101

Role of STAT3 in ischemic preconditioning.

Journal of molecular and cellular cardiology 20011101

Induction of the IL-13 receptor alpha2-chain by IL-4 and IL-13 in human keratinocytes: involvement of STAT6, ERK and p38 MAPK pathways.

Oncogene 20011011

Activation of the transcription factor NF-kappaB by the erythropoietin receptor: structural requirements and biological significance.

Cellular signalling 20010901

JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures.

Journal of neuroscience research 20010901

Constitutive activation of STAT transcription factors in acute myelogenous leukemia.

European journal of haematology 20010801

JAK/STAT signaling is associated with cardiac dysfunction during ischemia and reperfusion.

Circulation 20010717

Hydrogen peroxide is a novel inducer of connective tissue growth factor.

Biochemical and biophysical research communications 20010622

IL-6 upregulates its own receptor on some human myeloma cell lines.

Cytokine 20010621

Cooperative regulation of Mcl-1 by Janus kinase/stat and phosphatidylinositol 3-kinase contribute to granulocyte-macrophage colony-stimulating factor-delayed apoptosis in human neutrophils.

Journal of immunology (Baltimore, Md. : 1950) 20010615

Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells.

Blood 20010601

Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation.

Journal of hypertension 20010601

TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.

Leukemia 20010601

[The effect of AG490 on NK activity and lymphocyte transformation of PBMC].

Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao 20010601

Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells.

Oncogene 20010503

SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity.

Nature genetics 20010501

Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells.

Leukemia 20010501

Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells.

Experimental hematology 20010501

Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL--expressing cells, demonstrating synergy between AG490 and STI571.

Blood 20010401

Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.

Journal of immunology (Baltimore, Md. : 1950) 20010315

Characterization of a rat uterine cell line, U(III) cells: prolactin (PRL) expression and endogenous regulation of PRL-dependent genes; estrogen receptor beta, alpha(2)-macroglobulin, and decidual PRL involving the Jak2 and Stat5 pathway.

Endocrinology 20010301

Oncostatin M-induced matrix metalloproteinase and tissue inhibitor of metalloproteinase-3 genes expression in chondrocytes requires Janus kinase/STAT signaling pathway.

Journal of immunology (Baltimore, Md. : 1950) 20010301

Reactive oxygen species regulate heat-shock protein 70 via the JAK/STAT pathway.

Arteriosclerosis, thrombosis, and vascular biology 20010301

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.

The Journal of clinical investigation 20010201

LPS induction of I kappa B-alpha degradation and iNOS expression in a skin dendritic cell line is prevented by the janus kinase 2 inhibitor, Tyrphostin b42.

Nitric oxide : biology and chemistry 20010201

New dermatological agents for the treatment of psoriasis.

Journal of medicinal chemistry 20010201

Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells.

Journal of cellular biochemistry 20010101

Tyrphostin AG490 selectively inhibits activation of the JAK3/STAT5/MAPK pathway and rejection of rat heart allografts.

Transplantation proceedings 20010101

Modulation of primary T cell responses and tolerance induction by tyrphostin AG490.

Transplantation proceedings 20010101

Monocyte chemotactic protein 1 amplifies serotonin-induced vascular smooth muscle cell proliferation.

Journal of vascular research 20010101

IL-6 signaling by STAT3 participates in the change from hyperplasia to neoplasia in NRP-152 and NRP-154 rat prostatic epithelial cells.

BMC cancer 20010101

Naphthyl ketones: a new class of Janus kinase 3 inhibitors.

Bioorganic & medicinal chemistry letters 20000320

Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.

Biochemistry 19951121

Tyrphostins. 2. Heterocyclic and alpha-substituted benzylidenemalononitrile tyrphostins as potent inhibitors of EGF receptor and ErbB2/neu tyrosine kinases.

Journal of medicinal chemistry 19910601