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RO1138452

CAS No.:
221529-58-4
Catalog Number:
AG0038VS
Molecular Formula:
C19H23N3O
Molecular Weight:
309.4054
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$223
- +
10mg
98%
1 week
United States
$321
- +
25mg
98%
1 week
United States
$640
- +
50mg
98%
1 week
United States
$1057
- +
100mg
98%
1 week
United States
$1793
- +
Product Description
Catalog Number:
AG0038VS
Chemical Name:
RO1138452
CAS Number:
221529-58-4
Molecular Formula:
C19H23N3O
Molecular Weight:
309.4054
MDL Number:
MFCD08062147
IUPAC Name:
N-[4-[(4-propan-2-yloxyphenyl)methyl]phenyl]-4,5-dihydro-1H-imidazol-2-amine
InChI:
InChI=1S/C19H23N3O/c1-14(2)23-18-9-5-16(6-10-18)13-15-3-7-17(8-4-15)22-19-20-11-12-21-19/h3-10,14H,11-13H2,1-2H3,(H2,20,21,22)
InChI Key:
GYYRMJMXXLJZAB-UHFFFAOYSA-N
SMILES:
CC(Oc1ccc(cc1)Cc1ccc(cc1)NC1=NCCN1)C
UNII:
DH5W8F3S4H
Properties
Complexity:
380  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
309.184g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
309.413g/mol
Monoisotopic Mass:
309.184g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
45.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6  
Literature
Title Journal
Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Toxicology and applied pharmacology 20171101
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery. Pharmacological research 20120901
Prostacyclin receptor in tumor endothelial cells promotes angiogenesis in an autocrine manner. Cancer science 20120601
Tobacco smoke regulates the expression and activity of microsomal prostaglandin E synthase-1: role of prostacyclin and NADPH-oxidase. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon. Phytomedicine : international journal of phytotherapy and phytopharmacology 20110815
Glial cells isolated from dorsal root ganglia express prostaglandin E(2) (EP(4)) and prostacyclin (IP) receptors. European journal of pharmacology 20110701
PGE1 and PGE2 modify platelet function through different prostanoid receptors. Prostaglandins & other lipid mediators 20110201
Pharmacological and expression profile of the prostaglandin I(2) receptor in the rat craniovascular system. Vascular pharmacology 20110101
The effects of microsomal prostaglandin E synthase-1 deletion in acute cardiac ischemia in mice. Prostaglandins, leukotrienes, and essential fatty acids 20090701
Effect of vitamin B(6) vitamers on platelet aggregation. Platelets 20090301
4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXCL9 and CXCL10 release. The Journal of pharmacology and experimental therapeutics 20080201
Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. British journal of pharmacology 20060901
RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. British journal of pharmacology 20060201
Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists [corrected]. Bioorganic & medicinal chemistry letters 20040223
Properties