(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
| Title | Journal |
|---|---|
| Single-walled carbon nanotubes (SWCNTs) inhibit heat shock protein 90 (HSP90) signaling in human lung fibroblasts and keratinocytes. | Toxicology and applied pharmacology 20170815 |
| Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay. | Archives of toxicology 20170101 |
| Mitochondrial-targeted aryl hydrocarbon receptor and the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cellular respiration and the mitochondrial proteome. | Toxicology and applied pharmacology 20160801 |
| Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. | Archives of toxicology 20160101 |
| Solanesol protects human hepatic L02 cells from ethanol-induced oxidative injury via upregulation of HO-1 and Hsp70. | Toxicology in vitro : an international journal published in association with BIBRA 20150401 |
| The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. | The Journal of biological chemistry 20150116 |
| Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors. | European journal of medicinal chemistry 20141006 |
| N-acetylcysteine prevents the geldanamycin cytotoxicity by forming geldanamycin-N-acetylcysteine adduct. | Chemico-biological interactions 20140905 |
| Potential C-terminal-domain inhibitors of heat shock protein 90 derived from a C-terminal peptide helix. | Bioorganic & medicinal chemistry 20140801 |
| Cruentaren A binds F1F0 ATP synthase to modulate the Hsp90 protein folding machinery. | ACS chemical biology 20140418 |
| Potential role of HSP90 in mediating the interactions between estrogen receptor (ER) and aryl hydrocarbon receptor (AhR) signaling pathways. | Toxicology letters 20140407 |
| The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide. | Toxicology and applied pharmacology 20140101 |
| Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. | Toxicological sciences : an official journal of the Society of Toxicology 20131201 |
| Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15. | Journal of natural products 20130927 |
| Heat shock protein 90 is critical for regulation of phenotype and functional activity of human T lymphocytes and NK cells. | Journal of immunology (Baltimore, Md. : 1950) 20130201 |
| Pharmacological inhibition of HSP90 and ras activity as a new strategy in the treatment of HNSCC. | Journal of cellular physiology 20130101 |
| Expression of endothelial nitric oxide synthase protein is not necessary for mechanical strain-induced nitric oxide production by cultured osteoblasts. | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20121101 |
| Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. | Eukaryotic cell 20121101 |
| Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells. | Human molecular genetics 20121101 |
| 17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion. | Oncology reports 20121101 |
| New geldanamycin analogs from Streptomyces hygroscopicus. | Journal of microbiology and biotechnology 20121101 |
| Geldanamycin accelerated peripheral nerve regeneration in comparison to FK-506 in vivo. | Neuroscience 20121025 |
| Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells. | The Biochemical journal 20121015 |
| Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo. | The Journal of antibiotics 20121001 |
| Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness. | The Journal of biological chemistry 20120921 |
| Hsp90 binds microtubules and is involved in the reorganization of the microtubular network in angiosperms. | Journal of plant physiology 20120915 |
| Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects. | Proceedings of the National Academy of Sciences of the United States of America 20120911 |
| Combined effect of Hsp90 inhibitor geldanamycin and parthenolide via reactive oxygen species-mediated apoptotic process on epithelial ovarian cancer cells. | Basic & clinical pharmacology & toxicology 20120901 |
| Identification of 4,5-dihydro-4-hydroxygeldanamycins as shunt products of geldanamycin biosynthesis. | Journal of natural products 20120824 |
| Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. | Neoplasia (New York, N.Y.) 20120801 |
| A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast. | The Journal of biological chemistry 20120706 |
| Hydrogen sulfide protects SH-SY5Y cells against 6-hydroxydopamine-induced endoplasmic reticulum stress. | American journal of physiology. Cell physiology 20120701 |
| Nuclear shuttling precedes dimerization in mineralocorticoid receptor signaling. | Chemistry & biology 20120622 |
| Redox properties and thiol reactivity of geldanamycin and its analogues in aqueous solutions. | The journal of physical chemistry. B 20120607 |
| A role of Rab7 in stabilizing EGFR-Her2 and in sustaining Akt survival signal. | Journal of cellular physiology 20120601 |
| Systematic identification of the HSP90 candidate regulated proteome. | Molecular & cellular proteomics : MCP 20120601 |
| Inhibition of heat shock protein (Hsp) 27 potentiates the suppressive effect of Hsp90 inhibitors in targeting breast cancer stem-like cells. | Biochimie 20120601 |
| Acute inhibition of GSK causes mitochondrial remodeling. | American journal of physiology. Heart and circulatory physiology 20120601 |
| Geldanamycin and its derivatives as Hsp90 inhibitors. | Frontiers in bioscience (Landmark edition) 20120601 |
| Hsp90 interacts with AMPK and mediates acetyl-CoA carboxylase phosphorylation. | Cellular signalling 20120401 |
| Pho85, Pcl1, and Hms1 signaling governs Candida albicans morphogenesis induced by high temperature or Hsp90 compromise. | Current biology : CB 20120320 |
| Short peptide tools for monitoring caspase and proteasome activities in embryonal and adult rat brain lysates: an approach for the differential identification of proteases. | Journal of biochemistry 20120301 |
| Mapping the Hsp90 genetic interaction network in Candida albicans reveals environmental contingency and rewired circuitry. | PLoS genetics 20120301 |
| 17-O-demethylreblastatin, a subnormal intermediate in geldanamycin biosynthesis. | The Journal of antibiotics 20120201 |
| Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin. | Journal of the American Chemical Society 20120125 |
| The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library. | Angewandte Chemie (International ed. in English) 20120116 |
| UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition. | Experimental cell research 20120101 |
| RIP1 mediates the protection of geldanamycin on neuronal injury induced by oxygen-glucose deprivation combined with zVAD in primary cortical neurons. | Journal of neurochemistry 20120101 |
| Hsp90 inhibition differentially destabilises MAP kinase and TGF-beta signalling components in cancer cells revealed by kinase-targeted chemoproteomics. | BMC cancer 20120101 |
| Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii. | Malaria journal 20120101 |
| The effects of heat shock protein 90 inhibitors on apoptosis and viral replication in primary effusion lymphoma cells. | Biological & pharmaceutical bulletin 20120101 |
| Hsp90 is involved in apoptosis of Candida albicans by regulating the calcineurin-caspase apoptotic pathway. | PloS one 20120101 |
| Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells. | The Journal of toxicological sciences 20120101 |
| Heat shock protein 90 stabilizes nucleolin to increase mRNA stability in mitosis. | The Journal of biological chemistry 20111223 |
| Molecular mechanisms of cold-induced CYP1A activation in rat liver microsomes. | Journal of physiology and biochemistry 20111201 |
| Pharmacological inhibition of HSP90 activity negatively modulates myogenic differentiation and cell survival in C2C12 cells. | Molecular and cellular biochemistry 20111201 |
| Identification of heat-shock protein 90 beta in Japanese encephalitis virus-induced secretion proteins. | The Journal of general virology 20111201 |
| A small molecule that preferentially binds the closed conformation of Hsp90. | Bioorganic & medicinal chemistry letters 20111201 |
| Cyclic AMP induces IPC leukemia cell apoptosis via CRE-and CDK-dependent Bim transcription. | Cell death & disease 20111201 |
| Features of the Streptomyces hygroscopicus HtpG reveal how partial geldanamycin resistance can arise with mutation to the ATP binding pocket of a eukaryotic Hsp90. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111101 |
| Decreased tetrahydrobiopterin and disrupted association of Hsp90 with eNOS by hyperglycemia impair myocardial ischemic preconditioning. | American journal of physiology. Heart and circulatory physiology 20111101 |
| Geldanamycin is effective in the treatment of herpes simplex virus epithelial keratitis in a rabbit model. | Clinical & experimental ophthalmology 20111101 |
| Thermo-targeted drug delivery of geldanamycin to hyperthermic tumor margins with diblock elastin-based biopolymers. | Journal of controlled release : official journal of the Controlled Release Society 20111030 |
| The Rho1 GTPase-activating protein CgBem2 is required for survival of azole stress in Candida glabrata. | The Journal of biological chemistry 20110930 |
| Targeting the heat shock protein 90 dimer with dimeric inhibitors. | Journal of medicinal chemistry 20110922 |
| Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin. | Cell stress & chaperones 20110901 |
| Rescuing of deficient killing and phagocytic activities of macrophages derived from non-obese diabetic mice by treatment with geldanamycin or heat shock: potential clinical implications. | Cell stress & chaperones 20110901 |
| Geldanamycin analog 17-DMAG limits apoptosis in human peripheral blood cells by inhibition of p53 activation and its interaction with heat-shock protein 90 kDa after exposure to ionizing radiation. | Radiation research 20110901 |
| Genome shuffling enhances biocontrol abilities of Streptomyces strains against two potato pathogens. | Journal of applied microbiology 20110901 |
| One-electron reduction of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: a pulse radiolysis study. | The journal of physical chemistry. A 20110818 |
| Protein-selective capture to analyze electrophile adduction of hsp90 by 4-hydroxynonenal. | Chemical research in toxicology 20110815 |
| Inhibition of HSP90-dependent telomerase activity in amyloid β-induced apoptosis of cerebral endothelial cells. | Journal of cellular physiology 20110801 |
| Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110801 |
| Modulation of morphogenesis in Candida albicans by various small molecules. | Eukaryotic cell 20110801 |
| Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model. | Bioorganic & medicinal chemistry letters 20110801 |
| The missing C-17 O-methyltransferase in geldanamycin biosynthesis. | Organic letters 20110715 |
| Evidence for enhanced cytoprotective function of HSP90-overexpressing small intestinal epithelial cells. | Digestive diseases and sciences 20110701 |
| Obligatory role of heat shock protein 90 in iNOS induction. | American journal of physiology. Cell physiology 20110701 |
| Streptomyces autolyticus JX-47 large-insert bacterial artificial chromosome library construction and identification of clones covering geldanamycin biosynthesis gene cluster. | Current microbiology 20110701 |
| [Rapid identification of elaiophylin from Streptomyces hygroscopicus 17997, a geldanamycin producer]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20110701 |
| Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model. | Bioorganic & medicinal chemistry letters 20110615 |
| New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus. | The Journal of antibiotics 20110601 |
| The HSP90 molecular chaperone cycle regulates cyclical transcriptional dynamics of the glucocorticoid receptor and its coregulatory molecules CBP/p300 during ultradian ligand treatment. | Molecular endocrinology (Baltimore, Md.) 20110601 |
| Thiazinogeldanamycin, a new geldanamycin derivative produced by Streptomyces hygroscopicus 17997. | Journal of microbiology and biotechnology 20110601 |
| Associations of HSP90 client proteins in human breast cancer. | Anticancer research 20110601 |
| [Synthesis and antiviral activities of geldanamycin analog TC-GM in vitro]. | Yao xue xue bao = Acta pharmaceutica Sinica 20110601 |
| Gambogic acid, a natural product inhibitor of Hsp90. | Journal of natural products 20110527 |
| Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B. | Rheumatology (Oxford, England) 20110501 |
| Identification and initial SAR of silybin: an Hsp90 inhibitor. | Bioorganic & medicinal chemistry letters 20110501 |
| Pnck induces ligand-independent EGFR degradation by probable perturbation of the Hsp90 chaperone complex. | American journal of physiology. Cell physiology 20110501 |
| Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range. | Journal of neurochemistry 20110501 |
| Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity. | Bioorganic & medicinal chemistry letters 20110415 |
| Stabilization of phosphatidylinositol 4-kinase type IIbeta by interaction with Hsp90. | The Journal of biological chemistry 20110408 |
| In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes. | Drug metabolism and disposition: the biological fate of chemicals 20110401 |
| Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. | Cell death and differentiation 20110301 |
| Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 20110301 |
| Targeting PI3K/Akt/HSP90 signaling sensitizes gastric cancer cells to deoxycholate-induced apoptosis. | Digestive diseases and sciences 20110201 |
| A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: synthesis, structure-activity relationships and anti-HCV activity in GS4.3 replicon cells. | The Journal of antibiotics 20110201 |
| The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery? | British journal of pharmacology 20110101 |
| Influence of Hsp90 and HDAC inhibition and tubulin acetylation on perinuclear protein aggregation in human retinal pigment epithelial cells. | Journal of biomedicine & biotechnology 20110101 |
| Mechanisms by which interleukin-6 regulates prostate-specific antigen gene expression in prostate LNCaP carcinoma cells. | Journal of andrology 20110101 |
| A systematic protocol for the characterization of Hsp90 modulators. | Bioorganic & medicinal chemistry 20110101 |
| Rapid decrease of CD16 (FcγRIII) expression on heat-shocked neutrophils and their recognition by macrophages. | Journal of biomedicine & biotechnology 20110101 |
| Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage. | Acta neurochirurgica. Supplement 20110101 |
| Non-invasive, quantitative monitoring of hyperthermia-induced EGFR activation in xenograft tumours. | International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20110101 |
| Novel 4,5-dihydro-thiazinogeldanamycin in a gdmP mutant strain of Streptomyces hygroscopicus 17997. | Bioscience, biotechnology, and biochemistry 20110101 |
| Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytes. | BMC musculoskeletal disorders 20110101 |
| Heat shock protein 90 as a drug target against protozoan infections: biochemical characterization of HSP90 from Plasmodium falciparum and Trypanosoma evansi and evaluation of its inhibitor as a candidate drug. | The Journal of biological chemistry 20101203 |
| Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage. | Neurochemistry international 20101201 |
| Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3. | The international journal of biochemistry & cell biology 20101101 |
| A cell-based screen for inhibitors of protein folding and degradation. | Cell stress & chaperones 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Identification of three positive regulators in the geldanamycin PKS gene cluster of Streptomyces hygroscopicus JCM4427. | Journal of microbiology and biotechnology 20101101 |
| Hsp90 is required for transfer of the cholera toxin A1 subunit from the endoplasmic reticulum to the cytosol. | The Journal of biological chemistry 20101008 |
| Structure of the ATP-binding domain of Plasmodium falciparum Hsp90. | Proteins 20101001 |
| 7-O-descarbamoyl-7-hydroxygeldanamycin, a minor component from the gdmN disruption mutant of Streptomyces hygroscopicus 17997. | The Journal of antibiotics 20101001 |
| Protein complex formation with heat shock protein 90 in chronic hypoxia-induced pulmonary hypertension in newborn piglets. | American journal of physiology. Heart and circulatory physiology 20101001 |
| The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability. | The Journal of biological chemistry 20100924 |
| A new feature of the stress response: increase in endocytosis mediated by Hsp70. | Cell stress & chaperones 20100901 |
| Geldanamycin selectively targets the nascent form of ERBB3 for degradation. | Cell stress & chaperones 20100901 |
| Synthesis and biological evaluation of heat-shock protein 90 inhibitors: geldanamycin derivatives with broad antiviral activities. | Antiviral chemistry & chemotherapy 20100811 |
| Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. | Cellular signalling 20100801 |
| Geldanamycin and its analog induce cytotoxicity in cultured human retinal pigment epithelial cells. | Experimental eye research 20100801 |
| Heat shock protein 90 interacts with vitamin D receptor in human leukemia cells. | The Journal of steroid biochemistry and molecular biology 20100701 |
| Role of heat-shock protein 90 in hepatitis E virus capsid trafficking. | The Journal of general virology 20100701 |
| Geldanamycin-induced PCNA degradation in isolated Hsp90 complex from cancer cells. | Cancer investigation 20100701 |
| Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability. | Journal of neurochemistry 20100701 |
| [Progress in the study of heat shock protein 90 inhibitors]. | Yao xue xue bao = Acta pharmaceutica Sinica 20100701 |
| Cell-produced alpha-synuclein oligomers are targeted to, and impair, the 26S proteasome. | Neurobiology of aging 20100601 |
| Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs. | Free radical biology & medicine 20100601 |
| Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90. | PLoS neglected tropical diseases 20100601 |
| Role of heat shock protein hsp90 in formation of protective reactions in acute toxic stress. | Biochemistry. Biokhimiia 20100601 |
| Application of proteomic profiling based on 2D-DIGE for classification of compounds according to the mechanism of action. | Chemistry & biology 20100528 |
| Mutations that increase both Hsp90 ATPase activity in vitro and Hsp90 drug resistance in vivo. | Biochimica et biophysica acta 20100501 |
| Hsp90 inhibitors: a potential treatment for latent EBV infection? | Cell cycle (Georgetown, Tex.) 20100501 |
| ErbB2 trafficking and degradation associated with K48 and K63 polyubiquitination. | Cancer research 20100501 |
| Suppression of herpes simplex virus 1 reactivation in a mouse eye model by cyclooxygenase inhibitor, heat shock protein inhibitor, and adenosine monophosphate. | Japanese journal of ophthalmology 20100501 |
| Specific regulation of noncanonical p38alpha activation by Hsp90-Cdc37 chaperone complex in cardiomyocyte. | Circulation research 20100430 |
| Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension. | World journal of gastroenterology 20100421 |
| Geldanamycin and its anti-cancer activities. | Cancer letters 20100401 |
| The role of lysosomes in limiting drug toxicity in mice. | The Journal of pharmacology and experimental therapeutics 20100401 |
| Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals. | Journal of biomolecular screening 20100401 |
| The 90-kDa heat shock protein Hsp90 protects tubulin against thermal denaturation. | The Journal of biological chemistry 20100326 |
| Sperm protein 17 is a novel marker for predicting cisplatin response in esophageal squamous cancer cell lines. | International journal of cancer 20100315 |
| A new geldanamycin analogue from Streptomyces hygroscopicus. | Molecules (Basel, Switzerland) 20100303 |
| Geldanamycin inhibits TGF-beta signaling through induction of Hsp70. | Archives of biochemistry and biophysics 20100301 |
| Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines. | The Journal of pharmacology and experimental therapeutics 20100301 |
| The 26S proteasome function and Hsp90 activity involved in the regulation of HsfA2 expression in response to oxidative stress. | Plant & cell physiology 20100301 |
| Hsp90 inhibitors: clinical development and future opportunities in oncology therapy. | Current opinion in drug discovery & development 20100301 |
| Effect of the hsp90 inhibitor geldanamycin on androgen response of prostate cancer under hypoxic conditions. | International journal of urology : official journal of the Japanese Urological Association 20100301 |
| Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment. | Biochemical and biophysical research communications 20100219 |
| Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons. | Nature 20100204 |
| Differential alteration of heat shock protein 90 in mice modifies glucocorticoid receptor function and susceptibility to trauma. | Journal of neurotrauma 20100201 |
| A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein. | Molecular & cellular proteomics : MCP 20100201 |
| Plasmodial heat shock proteins: targets for chemotherapy. | FEMS immunology and medical microbiology 20100201 |
| Heat shock protein 90: inhibitors in clinical trials. | Journal of medicinal chemistry 20100114 |
| Distinct regulation of insulin receptor substrate-1 and -2 by 90-kDa heat-shock protein in adrenal chromaffin cells. | Neurochemistry international 20100101 |
| Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. | The Journal of biological chemistry 20100101 |
| The inhibitory mechanisms of the tyrosine kinase inhibitors herbimycin a, genistein, and tyrphostin B48 with regard to the function of the aryl hydrocarbon receptor in Caco-2 cells. | Bioscience, biotechnology, and biochemistry 20100101 |
| Cloning of an orange-spotted grouper Epinephelus coioides heat shock protein 90AB (HSP90AB) and characterization of its expression in response to nodavirus. | Fish & shellfish immunology 20100101 |
| Genetic variations of heat shock protein 84 in mice mediate cellular glucocorticoid response. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells. | Molecular cancer 20100101 |
| Induction of premature senescence by hsp90 inhibition in small cell lung cancer. | PloS one 20100101 |
| Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. | Neuroscience 20091229 |
| The Hsp90 inhibitor geldanamycin abrogates colocalization of eIF4E and eIF4E-transporter into stress granules and association of eIF4E with eIF4G. | The Journal of biological chemistry 20091218 |
| Design, synthesis, and biological activity of bicyclic radester analogues as Hsp90 inhibitors. | Bioorganic & medicinal chemistry letters 20091215 |
| Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications. | Cell cycle (Georgetown, Tex.) 20091201 |
| Modulation of Hsf1 activity by novobiocin and geldanamycin. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20091201 |
| The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells. | Oncogene 20091119 |
| Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex. | Free radical biology & medicine 20091115 |
| Systematically linking drug susceptibility to cancer genome aberrations. | Cell cycle (Georgetown, Tex.) 20091115 |
| Inhibition of constitutive and cxc-chemokine-induced NF-kappaB activity potentiates ansamycin-based HSP90-inhibitor cytotoxicity in castrate-resistant prostate cancer cells. | British journal of cancer 20091103 |
| Apoptosis caused by Hsp90 inhibitor geldanamycin in Leishmania donovani during promastigote-to-amastigote transformation stage. | Parasitology research 20091101 |
| Hsp90 Co-localizes with Rab-GDI-1 and regulates agonist-induced amylase release in AR42J cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20091101 |
| [Molecular therapy targeting protein misfolding and aggregation for the polyglutamine diseases]. | Rinsho shinkeigaku = Clinical neurology 20091101 |
| Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90. | Journal of molecular biology 20091002 |
| Functional characterization of orchardgrass endoplasmic reticulum-resident Hsp90 (DgHsp90) as a chaperone and an ATPase. | Plant physiology and biochemistry : PPB 20091001 |
| Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. | Biochimica et biophysica acta 20091001 |
| Anti-apoptotic effect of heat shock protein 90 on hypoxia-mediated cardiomyocyte damage is mediated via the phosphatidylinositol 3-kinase/AKT pathway. | Clinical and experimental pharmacology & physiology 20090901 |
| The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner. | Endocrinology 20090901 |
| Structure-based and in silico design of Hsp90 inhibitors. | ChemMedChem 20090901 |
| Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells. | Radiation research 20090901 |
| High anti tumor activity against rhabdomyosarcoma cells and low normal cells cytotoxicity of heat shock protein 90 inhibitors, with special emphasis on 17-[2-(pyrrolidin-1-yl)ethyl]-aminno-17-demethoxygeldanamycin. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090901 |
| Identification of new Hsp90 inhibitors by structure-based virtual screening. | Bioorganic & medicinal chemistry letters 20090815 |
| New, highly active nonbenzoquinone geldanamycin derivatives by using mutasynthesis. | Chembiochem : a European journal of chemical biology 20090720 |
| Hsp90 inhibitors, GA and 17AAG, lead to ER stress-induced apoptosis in rat histiocytoma. | Biochemical pharmacology 20090715 |
| Synthesis and evaluation of radamide analogues, a chimera of radicicol and geldanamycin. | The Journal of organic chemistry 20090703 |
| Low concentration of GA activates a preconditioning response in HepG2 cells during oxidative stress-roles of Hsp90 and vimentin. | Cell stress & chaperones 20090701 |
| [In vitro study of expression and effects of HSP70/HSP90 in nasopharyngeal carcinoma cells after thermotherapy]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20090701 |
| HSP90alpha and HSP90beta isoforms selectively modulate MHC class II antigen presentation in B cells. | Journal of immunology (Baltimore, Md. : 1950) 20090615 |
| Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors. | Organic letters 20090604 |
| Differential expression of HSP70 mRNA in the mouse brain after treatment with geldanamycin. | Neurological research 20090601 |
| Targetable HPMA copolymer-aminohexylgeldanamycin conjugates for prostate cancer therapy. | Pharmaceutical research 20090601 |
| Essential role of the 90-kilodalton heat shock protein in mediating nongenomic estrogen signaling in coronary artery smooth muscle. | The Journal of pharmacology and experimental therapeutics 20090601 |
| [Analysis of geldanamycin analogues in trace amounts by LC-MS/MS]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20090601 |
| Potent cytotoxic C-11 modified geldanamycin analogues. | Journal of medicinal chemistry 20090528 |
| Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. | Journal of molecular biology 20090522 |
| Novel immunoconjugates comprised of streptonigrin and 17-amino-geldanamycin attached via a dipeptide-p-aminobenzyl-amine linker system. | Bioorganic & medicinal chemistry letters 20090515 |
| Rational biosynthetic engineering for optimization of geldanamycin analogues. | Chembiochem : a European journal of chemical biology 20090504 |
| Insulin promotes the association of heat shock protein 90 with the inositol 1,4,5-trisphosphate receptor to dampen its Ca2+ release activity. | Endocrinology 20090501 |
| Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity. | Cellular signalling 20090501 |
| Heat shock protein gp96 interacts with protein phosphatase 5 and controls toll-like receptor 2 (TLR2)-mediated activation of extracellular signal-regulated kinase (ERK) 1/2 in post-hypoxic kidney cells. | The Journal of biological chemistry 20090501 |
| Inhibition of HGF/MET as therapy for malignancy. | Expert opinion on therapeutic targets 20090501 |
| Heat shock protein 90 is important for Sp1 stability during mitosis. | Journal of molecular biology 20090417 |
| Hydrating for resistance to radicicol. | ACS chemical biology 20090417 |
| Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins. | Pharmaceutical research 20090401 |
| High cytotoxic sensitivity of the oligodendrocyte precursor cells to HSP90 inhibitors in cell cultures. | Experimental neurology 20090401 |
| The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities. | Molecular and biochemical parasitology 20090401 |
| BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. | Molecular cancer therapeutics 20090401 |
| Discovery and development of heat shock protein 90 inhibitors. | Bioorganic & medicinal chemistry 20090315 |
| DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress. | Cancer research 20090315 |
| Heat shock protein 90 is involved in regulation of hypoxia-driven proliferation of embryonic neural stem/progenitor cells. | Cell stress & chaperones 20090301 |
| Inhibition of heat shock protein 90 sensitizes melanoma cells to thermosensitive ferromagnetic particle-mediated hyperthermia with low Curie temperature. | Cancer science 20090301 |
| The basal flux of Akt in the mitochondria is mediated by heat shock protein 90. | Journal of neurochemistry 20090301 |
| Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line. | Bioorganic & medicinal chemistry 20090215 |
| Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling. | Molecular immunology 20090201 |
| Inside the Hsp90 inhibitors binding mode through induced fit docking. | Journal of molecular graphics & modelling 20090201 |
| Role of heat shock protein 90 and endothelial nitric oxide synthase during early anesthetic and ischemic preconditioning. | Anesthesiology 20090201 |
| Expression of epidermal growth factor receptor or ErbB3 facilitates geldanamycin-induced down-regulation of ErbB2. | Molecular cancer research : MCR 20090201 |
| Indirect participation of Hsp90 in the regulation of the cyclin E turnover. | Biochemical pharmacology 20090115 |
| Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. | Bioorganic & medicinal chemistry 20090115 |
| High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. | American journal of physiology. Cell physiology 20090101 |
| Hsp40 couples with the CSPalpha chaperone complex upon induction of the heat shock response. | PloS one 20090101 |
| Effectiveness of 17DMAG, a geldanamycin derivative, in murine acute myeloid leukemia. | Acta haematologica 20090101 |
| [Geldanamycin administration reduces the number of HSP86-positive germ cells in the mouse embryo: preliminary results]. | Revue medicale de Bruxelles 20090101 |
| [The role of protein kinase SAPK/JNK in cell responses to low-intensity nonionizing radiation]. | Biofizika 20090101 |
| Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. | PloS one 20090101 |
| Heat shock protein 90 regulates the stability of MEKK3 in HEK293 cells. | Cellular immunology 20090101 |
| HSP90 inhibitors: multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy. | Current medicinal chemistry 20090101 |
| Geldanamycin induces production of heat shock protein 70 and partially attenuates ototoxicity caused by gentamicin in the organ of Corti explants. | Journal of biomedical science 20090101 |
| Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug delivery. | Molecular pharmaceutics 20090101 |
| Rational design and synthesis of ansa-adenosines as potential antitumor agents. | Nucleic acids symposium series (2004) 20090101 |
| Hsp-90 and the biology of nematodes. | BMC evolutionary biology 20090101 |
| Inhibition and function of heat shock proteins 70 and 90. | Current topics in medicinal chemistry 20090101 |
| Molecular or pharmacologic inhibition of the CD14 signaling pathway protects against burn-related myocardial inflammation and dysfunction. | Shock (Augusta, Ga.) 20081201 |
| Neurite outgrowth of NG108-15 cells induced by heat shock protein 90 inhibitors. | Cell biochemistry and function 20081201 |
| Geldanamycin-induced Lyn dissociation from aberrant Hsp90-stabilized cytosolic complex is an early event in apoptotic mechanisms in B-chronic lymphocytic leukemia. | Blood 20081201 |
| Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model. | Cancer chemotherapy and pharmacology 20081101 |
| Antagonistic effect of divalent cations Ca2+ and Mg2+ on the morphological development of Streptomyces hygroscopicus var. geldanus. | Applied microbiology and biotechnology 20081101 |
| Heat shock protein 90 regulates development in Dictyostelium discoideum. | Journal of molecular biology 20081031 |
| Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells. | The Journal of biological chemistry 20081024 |
| Hsp90-mediated assembly of the 26 S proteasome is involved in major histocompatibility complex class I antigen processing. | The Journal of biological chemistry 20081017 |
| Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. | Neuroscience 20081015 |
| Quercetin-induced ubiquitination and down-regulation of Her-2/neu. | Journal of cellular biochemistry 20081001 |
| Ligand and protein fishing with heat shock protein 90 coated magnetic beads. | Analytical chemistry 20081001 |
| Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells. | Journal of cell science 20081001 |
| Cisplatin abrogates the geldanamycin-induced heat shock response. | Molecular cancer therapeutics 20081001 |
| Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/p21 deficient colon carcinoma cells. | Oncogene 20080918 |
| Regulation of ER alpha signaling pathway in neuronal HN10 cells: role of protein acetylation and Hsp90. | Neurochemical research 20080901 |
| Geldanamycin protects rat brain through overexpression of HSP70 and reducing brain edema after cerebral focal ischemia. | Neurological research 20080901 |
| Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages. | Journal of leukocyte biology 20080901 |
| Heat shock protein 90-binding agents protect renal cells from oxidative stress and reduce kidney ischemia-reperfusion injury. | American journal of physiology. Renal physiology 20080801 |
| Hsp90 inhibitors reduce influenza virus replication in cell culture. | Virology 20080801 |
| Targeting Hsp90: small-molecule inhibitors and their clinical development. | Current opinion in pharmacology 20080801 |
| Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. | Cancer research 20080801 |
| Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras. | Cell cycle (Georgetown, Tex.) 20080801 |
| Comment on 'Lowpenetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras' by Park et al. | Cell cycle (Georgetown, Tex.) 20080801 |
| Re: Jin E and Santo M 'Neurite outgrowth of NG08-15 cells induced by heat shock protein 90 inhibitors'. | Cell biochemistry and function 20080801 |
| Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines. | Molecular cancer therapeutics 20080801 |
| Hsp90 regulates the phosphorylation and activity of serum- and glucocorticoid-regulated kinase-1. | The Journal of biological chemistry 20080704 |
| Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats. | Journal of controlled release : official journal of the Controlled Release Society 20080702 |
| Concerted actions of multiple transcription elements confer differential transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells. | Journal of cellular biochemistry 20080701 |
| Heat shock protein inhibitors increase the efficacy of measles virotherapy. | Gene therapy 20080701 |
| The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex. | Investigative ophthalmology & visual science 20080701 |
| Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin. | Leukemia 20080701 |
| The influence of morphology on geldanamycin production in submerged fermentations of Streptomyces hygroscopicus var. geldanus. | Applied microbiology and biotechnology 20080701 |
| [Roles of geldanamycin biosynthetic genes in Streptomyces hygroscopicus 17997]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20080701 |
| Total synthesis of the Hsp90 inhibitor geldanamycin. | Organic letters 20080619 |
| Predictive physiologically based pharmacokinetic model for antibody-directed enzyme prodrug therapy. | Drug metabolism and disposition: the biological fate of chemicals 20080601 |
| Geldanamycin inhibits tyrosine phosphorylation-dependent NF-kappaB activation. | Biochemical pharmacology 20080601 |
| Synthesis of Hsp90 inhibitor dimers as potential antitumor agents. | Bioorganic & medicinal chemistry 20080601 |
| Heat shock protein 90 inhibition in lung cancer. | Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080601 |
| Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427. | Journal of microbiology and biotechnology 20080601 |
| Activated protein C via PAR1 receptor regulates survival of neurons under conditions of glutamate excitotoxicity. | Biochemistry. Biokhimiia 20080601 |
| A new post-PKS modification process in the carbamoyltransferase gene inactivation strain of Streptomyces hygroscopicus 17997. | The Journal of antibiotics 20080601 |
| The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ. | Journal of molecular biology 20080523 |
| Hsp90-inhibitor geldanamycin abrogates G2 arrest in p53-negative leukemia cell lines through the depletion of Chk1. | Oncogene 20080515 |
| Glial cell line-derived neurotrophic factor reverses ethanol-mediated increases in tyrosine hydroxylase immunoreactivity via altering the activity of heat shock protein 90. | The Journal of biological chemistry 20080509 |
| Molecular characterization of macbecin as an Hsp90 inhibitor. | Journal of medicinal chemistry 20080508 |
| The LuxR family members GdmRI and GdmRII are positive regulators of geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. | Archives of microbiology 20080501 |
| L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner. | Neuroscience research 20080501 |
| Identification of RIP1 kinase as a specific cellular target of necrostatins. | Nature chemical biology 20080501 |
| Enhancement of geldanamycin production by pH shock in batch culture of Streptomyces hygroscopicus subsp. duamyceticus. | Journal of microbiology and biotechnology 20080501 |
| [The genes associated with geldanamycin inhibiting replication of herpes simplex virus type 1]. | Bing du xue bao = Chinese journal of virology 20080501 |
| [Regulatory genes of geldanamycin biosynthesis]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20080501 |
| Radicicol but not geldanamycin evokes oxidative stress response and efflux protein inhibition in ARPE-19 human retinal pigment epithelial cells. | European journal of pharmacology 20080428 |
| Hsp90 inhibition has opposing effects on wild-type and mutant p53 and induces p21 expression and cytotoxicity irrespective of p53/ATM status in chronic lymphocytic leukaemia cells. | Oncogene 20080410 |
| Protein phosphatase 5 is required for Hsp90 function during proteotoxic stresses in Trypanosoma brucei. | Parasitology research 20080401 |
| Proteasome-dependent pharmacological rescue of cystic fibrosis transmembrane conductance regulator revealed by mutation of glycine 622. | The Journal of pharmacology and experimental therapeutics 20080401 |
| Geldanamycin enhances hepatocyte growth factor stimulation of eNOS phosphorylation in endothelial cells. | European journal of pharmacology 20080317 |
| Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080315 |
| Heat shock protein 90beta: a novel mediator of vitamin D action. | Biochemical and biophysical research communications 20080314 |
| Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity. | Bioorganic & medicinal chemistry letters 20080301 |
| Geldanamycin-induced down-regulation of ErbB2 from the plasma membrane is clathrin dependent but proteasomal activity independent. | Molecular cancer research : MCR 20080301 |
| Prevention of chemotherapy-induced alopecia in rodent models. | Cell stress & chaperones 20080301 |
| [Effect of HSP90 function inhibited on the telomerase and P53 mutant in breast cancer cells]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080301 |
| Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90. | Journal of medicinal chemistry 20080214 |
| Geldanamycin augments nitric oxide production and promotes capacitation in boar spermatozoa. | Animal reproduction science 20080201 |
| Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites. | Organic & biomolecular chemistry 20080121 |
| Molecular imaging of the efficacy of heat shock protein 90 inhibitors in living subjects. | Cancer research 20080101 |
| Thrombospondin-1-induced migration is functionally dependent upon focal adhesion kinase. | Vascular and endovascular surgery 20080101 |
| Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor. | Angewandte Chemie (International ed. in English) 20080101 |
| [The role of heat shock proteins HSP90 in the response of immune cells to centimeter microwaves]. | Biofizika 20080101 |
| [The role of TLR4 receptor in the stress response of lymphocytes]. | Biofizika 20080101 |
| [Effect of geldanamycin on the expression of signal proteins and heat shock proteins in normal mice lymphocytes]. | Tsitologiia 20080101 |
| The stress responsive and morphologically regulated hsp90 gene from Paracoccidioides brasiliensis is essential to cell viability. | BMC microbiology 20080101 |
| Cytosolic HSP90 regulates the heat shock response that is responsible for heat acclimation in Arabidopsis thaliana. | The Journal of biological chemistry 20071228 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome. | American journal of medical genetics. Part A 20071215 |
| Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity. | Biochemistry 20071211 |
| Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin. | Molecular pharmacology 20071201 |
| A high-content glucocorticoid receptor translocation assay for compound mechanism-of-action evaluation. | Journal of biomolecular screening 20071201 |
| Derrubone, an inhibitor of the Hsp90 protein folding machinery. | Journal of natural products 20071201 |
| Functioning of the Hsp90 machine in chaperoning checkpoint kinase I (Chk1) and the progesterone receptor (PR). | Cell stress & chaperones 20071201 |
| IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. | Cell 20071116 |
| Aryl hydrocarbon receptor signaling in rainbow trout hepatocytes: role of hsp90 and the proteasome. | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20071101 |
| Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context. | Experimental cell research 20071101 |
| Involvement of the 90-kDa heat shock protein (Hsp-90) in CB2 cannabinoid receptor-mediated cell migration: a new role of Hsp-90 in migration signaling of a G protein-coupled receptor. | Molecular pharmacology 20071101 |
| Geldanamycin, a HSP90 inhibitor, attenuates the hypoxia-induced vascular endothelial growth factor expression in retinal pigment epithelium cells in vitro. | Experimental eye research 20071101 |
| HSP90 antagonist, geldanamycin, inhibits proliferation, induces apoptosis and blocks migration of rhabdomyosarcoma cells in vitro and seeding into bone marrow in vivo. | Anti-cancer drugs 20071101 |
| Heat Shock Protein 90 regulates the stability of c-Jun in HEK293 Cells. | Molecules and cells 20071031 |
| Catalytically active Yersinia outer protein P induces cleavage of RIP and caspase-8 at the level of the DISC independently of death receptors in dendritic cells. | Apoptosis : an international journal on programmed cell death 20071001 |
| Live cell imaging of interleukin-6-induced targeting of 'transcription factor' STAT3 to sequestering endosomes in the cytoplasm. | American journal of physiology. Cell physiology 20071001 |
| Cystein cathepsin and Hsp90 activities determine the balance between apoptotic and necrotic cell death pathways in caspase-compromised U937 cells. | Biochimica et biophysica acta 20071001 |
| The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation. | The Journal of pathology 20071001 |
| Opposite regulation of endothelial NO synthase by HSP90 and caveolin in liver and lungs of rats with hepatopulmonary syndrome. | American journal of physiology. Gastrointestinal and liver physiology 20071001 |
| [Geldanamycin inhibits proliferation and motility of human HER2/neu-overexpressing breast cancer cell line SKBr3]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20071001 |
| CHIP chaperones wild type p53 tumor suppressor protein. | The Journal of biological chemistry 20070928 |
| Intelligent biosynthetic nanobiomaterials for hyperthermic combination chemotherapy and thermal drug targeting of HSP90 inhibitor geldanamycin. | Journal of controlled release : official journal of the Controlled Release Society 20070911 |
| Mutasynthesis of geldanamycin by the disruption of a gene producing starter unit: generation of structural diversity at the benzoquinone ring. | Chembiochem : a European journal of chemical biology 20070903 |
| Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1. | Pharmaceutical research 20070901 |
| Geldanamycin inhibits hemorrhage-induced increases in caspase-3 activity: role of inducible nitric oxide synthase. | Journal of applied physiology (Bethesda, Md. : 1985) 20070901 |
| The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo. | Anti-cancer drugs 20070901 |
| Geldanamycin anisimycins activate Rho and stimulate Rho- and ROCK-dependent actin stress fiber formation. | Molecular cancer research : MCR 20070901 |
| Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized. | Cancer research 20070815 |
| Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells. | Proteomics 20070801 |
| Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes. | Arthritis and rheumatism 20070701 |
| Autophagy joins the game to regulate NF-kappaB signaling pathways. | Cell research 20070701 |
| Potentiation of chemotherapeutics by the Hsp90 antagonist geldanamycin requires a steady serum condition. | Molecular carcinogenesis 20070601 |
| Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. | Blood 20070601 |
| Heat shock protein 90 modulates endothelial nitric oxide synthase activity and vascular reactivity in the newborn piglet pulmonary circulation. | American journal of physiology. Lung cellular and molecular physiology 20070601 |
| Protective role of PI3-kinase-Akt-eNOS signalling pathway in intestinal injury associated with splanchnic artery occlusion shock. | British journal of pharmacology 20070601 |
| Low dose geldanamycin inhibits hepatocyte growth factor and hypoxia-stimulated invasion of cancer cells. | Cell cycle (Georgetown, Tex.) 20070601 |
| Hsp90 regulates processing of NF-kappa B2 p100 involving protection of NF-kappa B-inducing kinase (NIK) from autophagy-mediated degradation. | Cell research 20070601 |
| Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. | Virology 20070525 |
| Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1. | Biochemical pharmacology 20070515 |
| Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. | Archives of biochemistry and biophysics 20070515 |
| Geldanamycin derivatives and neuroprotective effect on cultured P19-derived neurons. | Bioorganic & medicinal chemistry letters 20070515 |
| Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells. | Leukemia 20070401 |
| Translocation of heparanase into nucleus results in cell differentiation. | Cancer science 20070401 |
| Effects of geldanamycin and thalidomide on the Th1/Th2 cytokine balance in mice subjected to operative trauma. | Surgery 20070401 |
| Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070401 |
| Relationship among ligand conformations in solution, in the solid state, and at the Hsp90 binding site: geldanamycin and radicicol. | Journal of the American Chemical Society 20070321 |
| Differential dynamics of Rab3A and Rab27A on secretory granules. | Journal of cell science 20070315 |
| Resistance to geldanamycin-induced apoptosis in differentiated neuroblastoma SH-SY5Y cells. | Neuroscience letters 20070306 |
| Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: functional effects of Hsp90 and PARP-1. | American journal of physiology. Renal physiology 20070301 |
| Role of 90-kDa heat shock protein (Hsp 90) and protein degradation in regulating neuronal levels of G protein-coupled receptor kinase 3. | The Journal of pharmacology and experimental therapeutics 20070301 |
| Hsp90 selectively modulates phenotype in vertebrate development. | PLoS genetics 20070301 |
| Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice. | Biochemical and biophysical research communications 20070223 |
| Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin. | Organic & biomolecular chemistry 20070207 |
| Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. | Carcinogenesis 20070201 |
| Molecular chaperones and protein kinase quality control. | Trends in cell biology 20070201 |
| Inhibitor of heat-shock protein 90 enhances the antitumor effect of DNA vaccine targeting clients of heat-shock protein. | Molecular therapy : the journal of the American Society of Gene Therapy 20070201 |
| Geldanamycin induces CHOP expression through a 4-(2-aminoethyl)-benzenesulfonyl fluoride-responsive serine protease. | Cell research 20070201 |
| Geldanamycin, a heat-shock protein 90-binding agent, induces thymocyte apoptosis through destabilization of Lck in presence of 12-O-tetradecanoylphorbol 13-acetate. | Biomedical research (Tokyo, Japan) 20070201 |
| Rapid activation of c-Src kinase by dioxin is mediated by the Cdc37-HSP90 complex as part of Ah receptor signaling in MCF10A cells. | Biochemistry 20070123 |
| Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance. | Genes & development 20070115 |
| The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells. | The Journal of biological chemistry 20070105 |
| Total synthesis of herbimycin A. | Organic letters 20070104 |
| Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages. | Molecular pharmacology 20070101 |
| Biotransformation of geldanamycin and 17-allylamino-17-demethoxygeldanamycin by human liver microsomes: reductive versus oxidative metabolism and implications. | Drug metabolism and disposition: the biological fate of chemicals 20070101 |
| Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue. | Cancer gene therapy 20070101 |
| Geldanamycin promotes nuclear localisation and clearance of PHOX2B misfolded proteins containing polyalanine expansions. | The international journal of biochemistry & cell biology 20070101 |
| Geldanamycin destabilizes HER2 tyrosine kinase and suppresses Wnt/beta-catenin signaling in HER2 overexpressing human breast cancer cells. | Oncology reports 20070101 |
| TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. | Cancer research 20070101 |
| Possible effects of early treatments of hsp90 inhibitors on preventing the evolution of drug resistance to other anti-cancer drugs. | Current medicinal chemistry 20070101 |
| Hsp90 inhibitor geldanamycin increases the sensitivity of resistant ovarian adenocarcinoma cell line A2780cis to cisplatin. | Neoplasma 20070101 |
| Targeting autophagic regulation of NFkappaB in HTLV-I transformed cells by geldanamycin: implications for therapeutic interventions. | Autophagy 20070101 |
| Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex. | Current medicinal chemistry 20070101 |
| Ligand-dependent and -independent degradation of the human aryl hydrocarbon receptor (hAHR) in cell culture models. | Chemico-biological interactions 20061201 |
| Geldanamycin, an inhibitor of Hsp90, blocks cytoplasmic retention of progesterone receptors and glucocorticoid receptors via their respective ligand binding domains. | The AAPS journal 20061201 |
| Hsp90 and the quantitative variation of wing shape in Drosophila melanogaster. | Evolution; international journal of organic evolution 20061201 |
| Lipophilic prodrugs of Hsp90 inhibitor geldanamycin for nanoencapsulation in poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles. | Journal of controlled release : official journal of the Controlled Release Society 20061128 |
| Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding. | The Journal of biological chemistry 20061110 |
| Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import. | The Journal of biological chemistry 20061103 |
| Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis. | Neurobiology of disease 20061101 |
| Hsp90 inhibition results in autophagy-mediated proteasome-independent degradation of IkappaB kinase (IKK). | Cell research 20061101 |
| HSP-90 inhibitors promise to complement cancer therapies. | Nature biotechnology 20061101 |
| Selective degradation of the IkappaB kinase (IKK) by autophagy. | Cell research 20061101 |
| [Cloning and analysis of geldanamycin partial biosynthetic gene cluster of Streptomyces hygroscopicus 17997]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20061101 |
| Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates. | Journal of medicinal chemistry 20061019 |
| Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90. | The EMBO journal 20061018 |
| The bioreduction of a series of benzoquinone ansamycins by NAD(P)H:quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins. | Molecular pharmacology 20061001 |
| Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. | Cancer cell 20061001 |
| Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90. | The Journal of organic chemistry 20060929 |
| Theileria-induced constitutive IKK activation is independent of functional Hsp90. | FEBS letters 20060918 |
| Stereoselective allyl transfer to chiral alpha-methoxycarbaldehydes: a model study related to the C-9/C-15 fragment of geldanamycin. | Bioorganic & medicinal chemistry 20060915 |
| Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection. | Cell death and differentiation 20060901 |
| Synthesis of a red-shifted fluorescence polarization probe for Hsp90. | Bioorganic & medicinal chemistry letters 20060901 |
| Endoplasmic reticulum vacuolization and valosin-containing protein relocalization result from simultaneous hsp90 inhibition by geldanamycin and proteasome inhibition by velcade. | Molecular cancer research : MCR 20060901 |
| Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling. | The Journal of biological chemistry 20060804 |
| Signal transduction in endothelial cells by the angiogenesis inhibitor histidine-rich glycoprotein targets focal adhesions. | Experimental cell research 20060801 |
| The biochemical role of the heat shock protein 90 chaperone complex in establishing human telomerase activity. | The Journal of biological chemistry 20060721 |
| Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection. | Circulation research 20060707 |
| Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation. | American journal of physiology. Heart and circulatory physiology 20060701 |
| Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase. | American journal of physiology. Gastrointestinal and liver physiology 20060701 |
| Synthesis of Hsp90 dimerization modulators. | Bioorganic & medicinal chemistry letters 20060701 |
| The topoisomerase II-Hsp90 complex: a new chemotherapeutic target? | International journal of cancer 20060601 |
| Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells. | The Journal of pharmacology and experimental therapeutics 20060601 |
| Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. | Protein science : a publication of the Protein Society 20060601 |
| American Association for Cancer Research--97th annual meeting. | IDrugs : the investigational drugs journal 20060601 |
| Interaction of pro-apoptotic protein HGTD-P with heat shock protein 90 is required for induction of mitochondrial apoptotic cascades. | FEBS letters 20060529 |
| Differential expression of Hsp90 isoforms in geldanamycin-treated 9L cells. | Biochemical and biophysical research communications 20060526 |
| Studies on the syntheses of benzoquinone ansamycin antibiotics. Syntheses of the C5-C15 subunits of macbecin I, geldanamycin, and herbimycin A. | Organic letters 20060525 |
| Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives. | Biochemistry 20060502 |
| Hsp90 inhibitors: small molecules that transform the Hsp90 protein folding machinery into a catalyst for protein degradation. | Medicinal research reviews 20060501 |
| Radanamycin, a macrocyclic chimera of radicicol and geldanamycin. | Bioorganic & medicinal chemistry letters 20060501 |
| Identification of genes involved in the sensitivity to antitumour drug 17-allylamino,17-demethoxygeldanamycin (17AAG). | Molecular bioSystems 20060501 |
| FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus. | The Journal of biological chemistry 20060421 |
| A role for the Hsp90 molecular chaperone family in antigen presentation to T lymphocytes via major histocompatibility complex class II molecules. | European journal of immunology 20060401 |
| Abnormal expression and distribution of heat shock protein 90: potential etiologic immunoendocrine mechanism of glucocorticoid resistance in idiopathic nephrotic syndrome. | Clinical and vaccine immunology : CVI 20060401 |
| Antagonist-induced, activation function-2-independent estrogen receptor alpha phosphorylation. | Molecular endocrinology (Baltimore, Md.) 20060301 |
| Identification of AHBA biosynthetic genes related to geldanamycin biosynthesis in Streptomyces hygroscopicus 17997. | Current microbiology 20060301 |
| Reaction of geldanamycin and C17-substituted analogues with glutathione: product identifications and pharmacological implications. | Chemical research in toxicology 20060301 |
| Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis. | Molecular cancer therapeutics 20060301 |
| Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: new insight into the formation of the benzoquinone moiety. | Chembiochem : a European journal of chemical biology 20060201 |
| AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70. | Chemistry & biology 20060201 |
| Association between Hsp90 and the ClC-2 chloride channel upregulates channel function. | American journal of physiology. Cell physiology 20060101 |
| Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells. | Journal of cellular biochemistry 20060101 |
| HSP90 protects apoptotic cleavage of vimentin in geldanamycin-induced apoptosis. | Molecular and cellular biochemistry 20060101 |
| Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way. | Journal of cell science 20060101 |
| Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycin. | Journal of biochemistry 20060101 |
| Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin. | Molecular cancer therapeutics 20060101 |
| Effects of geldanamycin on HIF-1alpha mediated angiogenesis and invasion in prostate cancer cells. | Prostate cancer and prostatic diseases 20060101 |
| Chaperoning oncogenes: Hsp90 as a target of geldanamycin. | Handbook of experimental pharmacology 20060101 |
| NMR backbone assignment of the N-terminal domain of human HSP90. | Journal of biomolecular NMR 20060101 |
| Effect of the Hsp90 modulators on the heat-shock response in eukaryotic cells. | Folia microbiologica 20060101 |
| Geldanamycin, radicicol, and chimeric inhibitors of the Hsp90 N-terminal ATP binding site. | Current topics in medicinal chemistry 20060101 |
| Increased superoxide generation and decreased stress protein Hsp90 expression in human umbilical cord vein endothelial cells (HUVECs) from pregnancies complicated by preeclampsia. | Hypertension in pregnancy 20060101 |
| TRIM5alpha association with cytoplasmic bodies is not required for antiretroviral activity. | Virology 20051220 |
| Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice. | The Journal of biological chemistry 20051202 |
| Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation. | Cellular signalling 20051201 |
| Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance. | Cancer chemotherapy and pharmacology 20051201 |
| CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. | Molecular endocrinology (Baltimore, Md.) 20051201 |
| In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allylaminogeldanamycin in rats. | Toxicology in vitro : an international journal published in association with BIBRA 20051201 |
| Analysis of hypoxia-inducible factor-1alpha accumulation and cell cycle in geldanamycin-treated human cervical carcinoma cells by laser scanning cytometry. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20051201 |
| Heat shock protein 90 inhibitors. A text book example of medicinal chemistry? | Journal of medicinal chemistry 20051201 |
| Ceramide mediates caspase-independent programmed cell death. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051201 |
| Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors. | Cancer research 20051201 |
| Role of the carboxy-terminal transactivation domain and active transcription in the ligand-induced and ligand-independent degradation of the mouse Ahb-1 receptor. | Biochemical pharmacology 20051125 |
| Cdk2: a genuine protein kinase client of Hsp90 and Cdc37. | Biochemistry 20051122 |
| Structure-based design of 7-carbamate analogs of geldanamycin. | Bioorganic & medicinal chemistry letters 20051115 |
| Hsp90alpha recruited by Sp1 is important for transcription of 12(S)-lipoxygenase in A431 cells. | The Journal of biological chemistry 20051028 |
| Increase in phagocytosis after geldanamycin treatment or heat shock: role of heat shock proteins. | Journal of immunology (Baltimore, Md. : 1950) 20051015 |
| ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. | Blood 20051001 |
| In vitro detection of differential and cell-specific hepatobiliary toxicity induced by geldanamycin and 17-allylaminogeldanamycin using dog liver slices. | Toxicological sciences : an official journal of the Society of Toxicology 20051001 |
| Effects of geldanamycin on hatching and juvenile motility in Caenorhabditis elegans and Heterodera glycines. | Journal of chemical ecology 20051001 |
| Inhibition of Hsp90 function delays and impairs recovery from heat shock. | The FEBS journal 20051001 |
| Geldanamycin-induced degradation of Chk1 is mediated by proteasome. | Biochemical and biophysical research communications 20050930 |
| Cell biology. A fungal Achilles' heel. | Science (New York, N.Y.) 20050930 |
| Heat shock prevents alpha-synuclein-induced apoptosis in a yeast model of Parkinson's disease. | Journal of molecular biology 20050902 |
| Geldanamycin derivative inhibition of HGF/SF-mediated Met tyrosine kinase receptor-dependent urokinase-plasminogen activation. | Bioorganic & medicinal chemistry 20050815 |
| Effects of organochlorine insecticides on MAP kinase pathways in human HaCaT keratinocytes: key role of reactive oxygen species. | Toxicological sciences : an official journal of the Society of Toxicology 20050801 |
| Toxoplasma gondii Hsp90 is a potential drug target whose expression and subcellular localization are developmentally regulated. | Journal of molecular biology 20050722 |
| Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. | Cancer research 20050715 |
| Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells. | Neuroscience letters 20050701 |
| Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. | Experimental cell research 20050701 |
| Heat shock protein 90 indirectly regulates ERK activity by affecting Raf protein metabolism. | Acta biochimica et biophysica Sinica 20050701 |
| Geldanamycin activates Hsp70 response and attenuates okadaic acid-induced cytotoxicity in human retinal pigment epithelial cells. | Brain research. Molecular brain research 20050613 |
| Phosphorylation of a tyrosine at the N-terminus regulates the surface expression of GIRK5 homomultimers. | FEBS letters 20050606 |
| Geldanamycin treatment reduces delayed CA1 damage in mouse hippocampal organotypic cultures subjected to oxygen glucose deprivation. | Neuroscience letters 20050603 |
| Apoptosis induction by a novel retinoid-related molecule requires nuclear factor-kappaB activation. | Cancer research 20050601 |
| Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90. | Assay and drug development technologies 20050601 |
| Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin. | Journal of radiation research 20050601 |
| Tungstate-induced color-pattern modifications of butterfly wings are independent of stress response and ecdysteroid effect. | Zoological science 20050601 |
| Geldanamycins exquisitely inhibit HGF/SF-mediated tumor cell invasion. | Oncogene 20050526 |
| Radester, a novel inhibitor of the Hsp90 protein folding machinery. | Organic letters 20050526 |
| Generation of a novel anti-geldanamycin antibody. | Biochemical and biophysical research communications 20050506 |
| Plasmodium falciparum calcineurin and its association with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin A and synergism with geldanamycin. | Molecular and biochemical parasitology 20050501 |
| Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS. | American journal of physiology. Lung cellular and molecular physiology 20050501 |
| Hsp90 is essential in the filarial nematode Brugia pahangi. | International journal for parasitology 20050501 |
| Transactivation of hsp70-1/2 in geldanamycin-treated human non-small cell lung cancer H460 cells: involvement of intracellular calcium and protein kinase C. | Journal of cellular biochemistry 20050415 |
| Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. | The Journal of biological chemistry 20050401 |
| Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT. | Genes & development 20050401 |
| Interleukin-1beta attenuates beta-very low-density lipoprotein uptake and its receptor expression in vascular smooth muscle cells. | Journal of molecular and cellular cardiology 20050401 |
| Production of 8-demethylgeldanamycin and 4,5-epoxy-8-demethylgeldanamycin from a recombinant strain of Streptomyces hygroscopicus. | Journal of natural products 20050401 |
| Kinase-addiction and bi-phasic sensitivity-resistance of Bcr-Abl- and Raf-1-expressing cells to imatinib and geldanamycin. | Cancer biology & therapy 20050401 |
| Hsp90 inhibitor geldanamycin increases hsp70 mRNA stabilisation but fails to activate HSF1 in cells exposed to hydrostatic pressure. | Biochimica et biophysica acta 20050322 |
| A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors. | The Journal of biological chemistry 20050318 |
| Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. | Cancer research 20050315 |
| Navigating the chaperone network: an integrative map of physical and genetic interactions mediated by the hsp90 chaperone. | Cell 20050311 |
| 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells. | Archives of biochemistry and biophysics 20050301 |
| Crystal structures of human HSP90alpha-complexed with dihydroxyphenylpyrazoles. | Bioorganic & medicinal chemistry letters 20050301 |
| Hsp90 protein in fission yeast Swo1p and UCS protein Rng3p facilitate myosin II assembly and function. | Eukaryotic cell 20050301 |
| Pim-1 kinase stability is regulated by heat shock proteins and the ubiquitin-proteasome pathway. | Molecular cancer research : MCR 20050301 |
| autoregulatory role of endothelium-derived nitric oxide (NO) on Lipopolysaccharide-induced vascular inducible NO synthase expression and function. | The Journal of biological chemistry 20050225 |
| Surface charge and hydrophobicity determine ErbB2 binding to the Hsp90 chaperone complex. | Nature structural & molecular biology 20050201 |
| STI571 (Glivec) inhibits the interaction between c-KIT and heat shock protein 90 of the gastrointestinal stromal tumor cell line, GIST-T1. | Cancer science 20050201 |
| Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila. | The Journal of biological chemistry 20050128 |
| Synthesis and enzyme-specific activation of carbohydrate-geldanamycin conjugates with potent anticancer activity. | Journal of medicinal chemistry 20050127 |
| Hsp90 inhibitors deplete key anti-apoptotic proteins in pediatric solid tumor cells and demonstrate synergistic anticancer activity with cisplatin. | International journal of cancer 20050110 |
| Up-regulation of the association between heat shock protein 90 and endothelial nitric oxide synthase prevents high glucose-induced apoptosis in human endothelial cells. | Journal of cellular biochemistry 20050101 |
| Chemical approaches to controlling intracellular protein degradation. | Chembiochem : a European journal of chemical biology 20050101 |
| Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90. | Journal of immunology (Baltimore, Md. : 1950) 20050101 |
| Hsp90 inhibitor geldanamycin and its derivatives as novel cancer chemotherapeutic agents. | Current pharmaceutical design 20050101 |
| Geldanamycin, a potent and specific inhibitor of Hsp90, inhibits gene expression and replication of human cytomegalovirus. | Antiviral chemistry & chemotherapy 20050101 |
| Measuring ubiquitin conjugation in cells. | Methods in molecular biology (Clifton, N.J.) 20050101 |
| Effects of small molecules on chaperone-mediated autophagy. | Autophagy 20050101 |
| Geldanamycin induces mitotic catastrophe and subsequent apoptosis in human glioma cells. | Journal of cellular physiology 20041201 |
| Caspase-dependent, geldanamycin-enhanced cleavage of co-chaperone p23 in leukemic apoptosis. | Leukemia 20041201 |
| Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice. | Cancer chemotherapy and pharmacology 20041201 |
| Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition. | Chemistry & biology 20041201 |
| Design, synthesis, and evaluation of a radicicol and geldanamycin chimera, radamide. | Organic letters 20041125 |
| Hsp90 chaperones wild-type p53 tumor suppressor protein. | The Journal of biological chemistry 20041119 |
| Characterization of a novel interaction between the secretory Na+-K+-Cl- cotransporter and the chaperone hsp90. | The Journal of biological chemistry 20041112 |
| Recurrent fever promotes Plasmodium falciparum development in human erythrocytes. | The Journal of biological chemistry 20041105 |
| A drastic reduction in the basal level of heat-shock protein 90 in the brain of goldfish (Carassius auratus) after administration of geldanamycin. | Zoological science 20041101 |
| Geldanamycin analogs. | Journal of chemotherapy (Florence, Italy) 20041101 |
| Src tyrosine kinase regulates CYP17 expression and androstenedione secretion in theca-enriched mouse ovarian cells. | Endocrine 20041101 |
| Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. | Bioorganic & medicinal chemistry 20041015 |
| Repression of hsp90beta gene by p53 in UV irradiation-induced apoptosis of Jurkat cells. | The Journal of biological chemistry 20041008 |
| Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin. | Journal of the American Chemical Society 20040915 |
| Regulation of vascular endothelial growth factor receptor 2-mediated phosphorylation of focal adhesion kinase by heat shock protein 90 and Src kinase activities. | The Journal of biological chemistry 20040910 |
| Heat shock protein-90 dampens and directs signaling stimulated by insulin-like growth factor-1 and insulin. | FEBS letters 20040910 |
| Autocrine extracellular signal-regulated kinase (ERK) activation in normal human keratinocytes: metalloproteinase-mediated release of amphiregulin triggers signaling from ErbB1 to ERK. | Molecular biology of the cell 20040901 |
| Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro. | Biochemical and biophysical research communications 20040827 |
| Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70. | Journal of applied physiology (Bethesda, Md. : 1985) 20040801 |
| Luminal flow induces eNOS activation and translocation in the rat thick ascending limb. II. Role of PI3-kinase and Hsp90. | American journal of physiology. Renal physiology 20040801 |
| Heat shock protein 90 transfection reduces ischemia-reperfusion-induced myocardial dysfunction via reciprocal endothelial NO synthase serine 1177 phosphorylation and threonine 495 dephosphorylation. | Arteriosclerosis, thrombosis, and vascular biology 20040801 |
| Development of a fluorescence polarization assay for the molecular chaperone Hsp90. | Journal of biomolecular screening 20040801 |
| Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury. | The Journal of experimental biology 20040801 |
| [Heat shock protein 90: novel target for cancer therapy]. | Ai zheng = Aizheng = Chinese journal of cancer 20040801 |
| Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-kappaB. | Biochemical and biophysical research communications 20040730 |
| Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90. | Journal of medicinal chemistry 20040715 |
| Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation. | Oncogene 20040708 |
| Pituitary expression of type I and type II glucocorticoid receptors during chicken embryonic development and their involvement in growth hormone cell differentiation. | Endocrinology 20040701 |
| Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach. | Human molecular genetics 20040701 |
| Quantum chemical calculations and mutational analysis suggest heat shock protein 90 catalyzes trans-cis isomerization of geldanamycin. | Chemistry & biology 20040701 |
| Isolation and characterization of novel geldanamycin analogues. | The Journal of antibiotics 20040701 |
| Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions. | Biochemistry 20040629 |
| Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a. | The Journal of biological chemistry 20040625 |
| Biotinylated geldanamycin. | The Journal of organic chemistry 20040625 |
| Molecular chaperones affect GTP cyclohydrolase I mutations in dopa-responsive dystonia. | Annals of neurology 20040601 |
| Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteria. | Eukaryotic cell 20040601 |
| Destabilization of the non-pathogenic, cellular prion-protein by a small molecular drug. | Antiviral therapy 20040601 |
| The induction of heat shock proteins as a potential strategy to treat neurodegenerative disorders. | Drug news & perspectives 20040601 |
| Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus. | The Journal of biological chemistry 20040521 |
| Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling. | The Journal of biological chemistry 20040507 |
| Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK-independent cell cycle arrest. | International journal of cancer 20040501 |
| Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. | Molecular cancer therapeutics 20040501 |
| [Involvement of Hsp90 in the quality control of signal transducing proteins]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20040501 |
| [Therapeutic targets in polyglutamine diseases]. | Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20040501 |
| Clinical trials referral resource. Current clinical trials of 17-AG and 17-DMAG. | Oncology (Williston Park, N.Y.) 20040501 |
| Aryl hydrocarbon nuclear translocator (ARNT) promotes oxygen-independent stabilization of hypoxia-inducible factor-1alpha by modulating an Hsp90-dependent regulatory pathway. | The Journal of biological chemistry 20040416 |
| Progesterone receptor deficient in chromatin binding has an altered cellular state. | The Journal of biological chemistry 20040409 |
| Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation. | Brain research. Molecular brain research 20040407 |
| PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. | The Journal of biological chemistry 20040402 |
| CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. | Human molecular genetics 20040401 |
| Functional characterization of aryl hydrocarbon receptor (zfAHR2) localization and degradation in zebrafish (Danio rerio). | Biochemical pharmacology 20040401 |
| Estrogen and regulation of heat shock protein expression in female cardiomyocytes: cross-talk with NF kappa B signaling. | Journal of molecular and cellular cardiology 20040401 |
| Heat-shock treatment-mediated increase in transduction by recombinant adeno-associated virus 2 vectors is independent of the cellular heat-shock protein 90. | The Journal of biological chemistry 20040326 |
| Hsp90 inhibitors attenuate effect of dexamethasone on activated NF-kappaB and AP-1. | Life sciences 20040305 |
| Geldanamycin and herbimycin A induce apoptotic killing of B chronic lymphocytic leukemia cells and augment the cells' sensitivity to cytotoxic drugs. | Blood 20040301 |
| Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. | Cellular signalling 20040301 |
| Geldanamycin, a ligand of heat shock protein 90, inhibits the replication of herpes simplex virus type 1 in vitro. | Antimicrobial agents and chemotherapy 20040301 |
| Cooperation of heat shock protein 90 and p23 in aryl hydrocarbon receptor signaling. | Cell stress & chaperones 20040301 |
| Geldanamycin-associated inhibition of intracellular trafficking is attributed to a co-purified activity. | The Journal of biological chemistry 20040220 |
| Herceptin-geldanamycin immunoconjugates: pharmacokinetics, biodistribution, and enhanced antitumor activity. | Cancer research 20040215 |
| Geldanamycin, a heat shock protein 90-binding agent, disrupts Stat5 activation in IL-2-stimulated cells. | Journal of cellular physiology 20040201 |
| Hair growth induction by the Tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040201 |
| Hypoxia increases Hsp90 binding to eNOS via PI3K-Akt in porcine coronary artery endothelium. | Laboratory investigation; a journal of technical methods and pathology 20040201 |
| Characterization of programmed cell death 4 in multiple human cancers reveals a novel enhancer of drug sensitivity. | Molecular cancer therapeutics 20040201 |
| Altered states: selectively drugging the Hsp90 cancer chaperone. | Trends in molecular medicine 20040201 |
| Modulation of dexamethasone-induced thymocyte apoptosis by heat-shock protein 90-binding agents. | The Bulletin of Tokyo Dental College 20040201 |
| Protein chaperones as anticancer therapy targets. | Clinical advances in hematology & oncology : H&O 20040201 |
| Regulation of nuclear retention of glucocorticoid receptor by nuclear Hsp90. | Molecular and cellular endocrinology 20040115 |
| [Role of heat shock protein 90 in hyperdynamic circulation of portal hypertensive rats]. | Zhonghua yi xue za zhi 20040102 |
| Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101 |
| Chemical genomics: probing protein function using small molecules. | American journal of pharmacogenomics : genomics-related research in drug development and clinical practice 20040101 |
| Blind cavefish and heat shock protein chaperones: a novel role for hsp90alpha in lens apoptosis. | The International journal of developmental biology 20040101 |
| G protein-coupled receptor kinase interaction with Hsp90 mediates kinase maturation. | The Journal of biological chemistry 20031219 |
| Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. | Cancer research 20031215 |
| Rapid inhibition of vasoconstriction in renal afferent arterioles by aldosterone. | Circulation research 20031212 |
| Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37. | Oncogene 20031211 |
| Extended rat liver slice survival and stability monitored using clinical biomarkers. | Biochemical and biophysical research communications 20031205 |
| Tyrosine phosphorylation of HSP-90 during mammalian sperm capacitation. | Biology of reproduction 20031201 |
| Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation. | International journal of radiation biology 20031201 |
| Molecular cloning of the 82-kDa heat shock protein (HSP90) of Toxoplasma gondii associated with the entry into and growth in host cells. | Biochemical and biophysical research communications 20031121 |
| Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2 in Saccharomyces cerevisiae. | FEBS letters 20031120 |
| The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells. | Cancer research 20031115 |
| Free and N-(2-hydroxypropyl)methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells. | Cancer research 20031115 |
| Regulation of vascular endothelial growth factor expression by insulin-like growth factor I in thyroid carcinomas. | The Journal of clinical endocrinology and metabolism 20031101 |
| [Hsp90: how a chaperone becomes a pharmacological target]. | Bulletin du cancer 20031101 |
| Evidence that intracellular beta1-2 mannan is a virulence factor in Leishmania parasites. | The Journal of biological chemistry 20031017 |
| Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin: asymmetric glycolate aldol reactions and biological evaluation. | The Journal of organic chemistry 20031017 |
| Selective synthesis of the para-quinone region of geldanamycin. | Organic letters 20031016 |
| Hormone-refractory breast cancer remains sensitive to the antitumor activity of heat shock protein 90 inhibitors. | Clinical cancer research : an official journal of the American Association for Cancer Research 20031015 |
| The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. | Molecular endocrinology (Baltimore, Md.) 20031001 |
| Geldanamycin reduces necrotic and apoptotic injury due to oxygen-glucose deprivation in astrocytes. | Neurological research 20031001 |
| Tyrosine phosphorylation of HSP90 within the P2X7 receptor complex negatively regulates P2X7 receptors. | The Journal of biological chemistry 20030926 |
| Heat shock protein-90 (Hsp90) acts as a repressor of peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARbeta activity. | Biochemistry 20030916 |
| KSHV vFLIP binds to IKK-gamma to activate IKK. | Journal of cell science 20030915 |
| Design of quinolinedione-based geldanamycin analogues. | Bioorganic & medicinal chemistry letters 20030915 |
| Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events. | The Journal of biological chemistry 20030912 |
| NMR chemical shift perturbation study of the N-terminal domain of Hsp90 upon binding of ADP, AMP-PNP, geldanamycin, and radicicol. | Chembiochem : a European journal of chemical biology 20030905 |
| Modulation of prion protein structural integrity by geldanamycin. | Glycobiology 20030901 |
| Fever-like temperature induces maturation of dendritic cells through induction of hsp90. | International immunology 20030901 |
| Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation. | Pharmacogenetics 20030901 |
| The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol. | The Journal of biological chemistry 20030822 |
| Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase. | American journal of physiology. Heart and circulatory physiology 20030801 |
| CAIR-1/BAG-3 abrogates heat shock protein-70 chaperone complex-mediated protein degradation: accumulation of poly-ubiquitinated Hsp90 client proteins. | The Journal of biological chemistry 20030801 |
| Geldanamycin inhibits migration of glioma cells in vitro: a potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion. | Journal of cellular physiology 20030801 |
| The Hsp90 chaperone complex as a novel target for cancer therapy. | Annals of oncology : official journal of the European Society for Medical Oncology 20030801 |
| Antagonistic properties of two recombinant strains of Streptomyces melanosporofaciens obtained by intraspecific protoplast fusion. | Applied microbiology and biotechnology 20030801 |
| The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome. | The EMBO journal 20030715 |
| Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system. | The EMBO journal 20030715 |
| The heat shock protein 90-binding geldanamycin inhibits cancer cell proliferation, down-regulates oncoproteins, and inhibits epidermal growth factor-induced invasion in thyroid cancer cell lines. | The Journal of clinical endocrinology and metabolism 20030701 |
| [Raf kinase and its inhibitory regulators]. | Sheng li ke xue jin zhan [Progress in physiology] 20030701 |
| [Establishment of gene transduction system in geldanamycin producer - Streptomyces hygroscopicus 17997 and its application for gene disruption experiment]. | Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20030701 |
| Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. | Circulation research 20030627 |
| PTHrP [67-86] regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression. | Journal of cell science 20030615 |
| Geldanamycin and its 17-allylamino-17-demethoxy analogue antagonize the action of Cisplatin in human colon adenocarcinoma cells: differential caspase activation as a basis for interaction. | Cancer research 20030615 |
| Autoregulation of glucocorticoid receptor by cortisol in rainbow trout hepatocytes. | American journal of physiology. Cell physiology 20030601 |
| Polymorphic glutathione S-transferase subunit 3 of rat liver exhibits different susceptibilities to carbon tetrachloride: differences in their interactions with heat-shock protein 90. | The Biochemical journal 20030601 |
| Geldanamycin induction of grp78 requires activation of reactive oxygen species via ER stress responsive elements in 9L rat brain tumour cells. | Cellular signalling 20030601 |
| Filter binding assay for the geldanamycin-heat shock protein 90 interaction. | Analytical biochemistry 20030601 |
| Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes. | The Journal of biological chemistry 20030516 |
| Inhibition of complex glycosylation increases the formation of PrPsc. | Traffic (Copenhagen, Denmark) 20030501 |
| Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells. | Carcinogenesis 20030501 |
| ErbB2 degradation mediated by the co-chaperone protein CHIP. | The Journal of biological chemistry 20030418 |
| Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein. | Biochemical and biophysical research communications 20030418 |
| Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90. | Chemistry & biology 20030401 |
| Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. | The Biochemical journal 20030315 |
| Functional analysis of murine aryl hydrocarbon (AH) receptors defective in nuclear import: impact on AH receptor degradation and gene regulation. | Molecular pharmacology 20030301 |
| JlpA of Campylobacter jejuni interacts with surface-exposed heat shock protein 90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38 MAP kinase in epithelial cells. | Cellular microbiology 20030301 |
| Disruption of HSP90 function reverts tumor necrosis factor-induced necrosis to apoptosis. | The Journal of biological chemistry 20030221 |
| C-terminal Hsp-interacting protein slows androgen receptor synthesis and reduces its rate of degradation. | Archives of biochemistry and biophysics 20030201 |
| Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts. | Arthritis and rheumatism 20030201 |
| 17AAG: low target binding affinity and potent cell activity--finding an explanation. | Molecular cancer therapeutics 20030201 |
| Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602. | FEMS microbiology letters 20030128 |
| Involvement of heat-shock protein 90 in the interleukin-6-mediated signaling pathway through STAT3. | Biochemical and biophysical research communications 20030124 |
| Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas. | International journal of cancer 20030120 |
| Yeast is selectively hypersensitised to heat shock protein 90 (Hsp90)-targetting drugs with heterologous expression of the human Hsp90beta, a property that can be exploited in screens for new Hsp90 chaperone inhibitors. | Gene 20030102 |
| Identification of ErbB-2 kinase domain motifs required for geldanamycin-induced degradation. | Cancer research 20030101 |
| [Molecular chaperone HSP90 as a novel target for cancer chemotherapy]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20030101 |
| Src tyrosine kinase but not activated Ras augments sensitivity to taxanes through apoptosis in human adenocarcinoma cells. | Anticancer research 20030101 |
| Integrin alphavbeta3, requirement for VEGFR2-mediated activation of SAPK2/p38 and for Hsp90-dependent phosphorylation of focal adhesion kinase in endothelial cells activated by VEGF. | Cell stress & chaperones 20030101 |
| Expression of a unique drug-resistant Hsp90 ortholog by the nematode Caenorhabditis elegans. | Cell stress & chaperones 20030101 |
| The heat shock protein 90 of Plasmodium falciparum and antimalarial activity of its inhibitor, geldanamycin. | Malaria journal 20030101 |
| Transient osmotic stress facilitates mutant huntingtin aggregation. | Neuroreport 20021220 |
| Assembly of the SMRT-histone deacetylase 3 repression complex requires the TCP-1 ring complex. | Genes & development 20021215 |
| Inhibition of HSP90 in Trypanosoma cruzi induces a stress response but no stage differentiation. | Eukaryotic cell 20021201 |
| Hemin-mediated restoration of allylisopropylacetamide-inactivated CYP2B1: a role for glutathione and GRP94 in the heme-protein assembly. | Archives of biochemistry and biophysics 20021201 |
| Inhibition of medullary thyroid carcinoma cell proliferation and RET phosphorylation by tyrosine kinase inhibitors. | Surgery 20021201 |
| Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever. | The Journal of biological chemistry 20021122 |
| Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. | The EMBO journal 20021115 |
| Effect of heat stress on lipopolysaccharide-induced vascular permeability change in mice. | The Journal of pharmacology and experimental therapeutics 20021101 |
| Pharmacological prevention of Parkinson disease in Drosophila. | Nature medicine 20021101 |
| Total synthesis of (+)-geldanamycin and (-)-o-quinogeldanamycin with use of asymmetric anti- and syn-glycolate aldol reactions. | Organic letters 20021003 |
| Inhibition of arachidonic acid release from human peripheral mononuclear cells by heat shock treatment and geldanamycin. | Immunology letters 20021001 |
| Ligand-dependent and independent modulation of aryl hydrocarbon receptor localization, degradation, and gene regulation. | Molecular pharmacology 20021001 |
| Down-regulation of cell surface insulin receptor and insulin receptor substrate-1 phosphorylation by inhibitor of 90-kDa heat-shock protein family: endoplasmic reticulum retention of monomeric insulin receptor precursor with calnexin in adrenal chromaffin cells. | Molecular pharmacology 20021001 |
| Mechanism of antiandrogen action: key role of hsp90 in conformational change and transcriptional activity of the androgen receptor. | Biochemistry 20021001 |
| Heat shock protein and proteasome targeting agents. | Hematology/oncology clinics of North America 20021001 |
| Use of radiolabelled choline as a pharmacodynamic marker for the signal transduction inhibitor geldanamycin. | British journal of cancer 20020923 |
| Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis. | The Journal of biological chemistry 20020920 |
| Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly. | The Journal of biological chemistry 20020913 |
| Hsp90 interactions and acylation target the G protein Galpha 12 but not Galpha 13 to lipid rafts. | The Journal of biological chemistry 20020906 |
| Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. | Circulation research 20020823 |
| Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase. | The Journal of biological chemistry 20020712 |
| Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis. | International journal of cancer 20020701 |
| hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90. | The Journal of biological chemistry 20020607 |
| Microtubule-active agents modify nitric oxide production in pulmonary artery endothelial cells. | American journal of physiology. Lung cellular and molecular physiology 20020601 |
| [Heat shock activated Rac-MEKK-JNK pathway and hsp90 beta gene expression]. | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20020601 |
| Evidence that protein phosphatase 5 functions to negatively modulate the maturation of the Hsp90-dependent heme-regulated eIF2alpha kinase. | Biochemistry 20020528 |
| Drug-induced ubiquitylation and degradation of ErbB receptor tyrosine kinases: implications for cancer therapy. | The EMBO journal 20020515 |
| Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras. | The Journal of biological chemistry 20020510 |
| Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. | Cancer research 20020501 |
| Requirement for a hsp90 chaperone-dependent MEK1/2-ERK pathway for B cell antigen receptor-induced cyclin D2 expression in mature B lymphocytes. | The Journal of biological chemistry 20020405 |
| VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition. | Blood 20020401 |
| Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. | Leukemia 20020401 |
| Geldanamycin induces heat shock proteins in brain and protects against focal cerebral ischemia. | Journal of neurochemistry 20020401 |
| Pharmacological approaches to defining the role of chaperones in aging and prostate cancer progression. | Cell stress & chaperones 20020401 |
| HSP90 inhibitors alter capsaicin- and ATP-induced currents in rat dorsal root ganglion neurons. | Neuroreport 20020325 |
| A Nucleotide-dependent molecular switch controls ATP binding at the C-terminal domain of Hsp90. N-terminal nucleotide binding unmasks a C-terminal binding pocket. | The Journal of biological chemistry 20020301 |
| HSP90 function is required for morphogenesis in ascidian and echinoid embryos. | Development genes and evolution 20020301 |
| Geldanamycin inhibits trichostatin A-induced cell death and histone H4 hyperacetylation in COS-7 cells. | Life sciences 20020301 |
| Suppressive effects of ansamycins on inducible nitric oxide synthase expression and the development of experimental autoimmune encephalomyelitis. | Journal of neuroscience research 20020215 |
| Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020201 |
| Geldanamycin specifically modulates thrombin-mediated morphological changes in mouse neuroblasts. | Journal of neurochemistry 20020201 |
| TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. | Molecular cell 20020201 |
| Influence of the structure of drug moieties on the in vitro efficacy of HPMA copolymer-geldanamycin derivative conjugates. | Pharmaceutical research 20020201 |
| Stress preconditioning attenuates oxidative injury to the alveolar epithelium of the lung following haemorrhage in rats. | The Journal of physiology 20020115 |
| Geldanamycin attenuates NO-mediated dilation in human skin. | American journal of physiology. Heart and circulatory physiology 20020101 |
| Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2. | Journal of neurobiology 20020101 |
| Hsp90, not Grp94, regulates the intracellular trafficking and stability of nascent ErbB2. | Cell stress & chaperones 20020101 |
| Effect of geldanamycin on androgen receptor function and stability. | Cell stress & chaperones 20020101 |
| Hsp90 inhibitors as novel cancer chemotherapeutic agents. | Trends in molecular medicine 20020101 |
| Modifications in synthesis strategy improve the yield and efficacy of geldanamycin-herceptin immunoconjugates. | Bioconjugate chemistry 20020101 |
| ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin. | Anticancer research 20020101 |
| ATPase inhibitors suppress actinomycin D-induced apoptosis in leukemia cells. | Anticancer research 20020101 |
| Activated c-Met signals through PI3K with dramatic effects on cytoskeletal functions in small cell lung cancer. | Journal of cellular and molecular medicine 20020101 |
| Determination of the enhancing action of HSP90 on neuronal nitric oxide synthase by EPR spectroscopy. | American journal of physiology. Cell physiology 20011201 |
| Geldanamycin restores a defective heat shock response in vivo. | The Journal of biological chemistry 20011130 |
| GERp95 belongs to a family of signal-transducing proteins and requires Hsp90 activity for stability and Golgi localization. | The Journal of biological chemistry 20011116 |
| Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53. | The EMBO journal 20011115 |
| Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. | Circulation research 20011109 |
| Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization. | The Journal of biological chemistry 20011102 |
| The heat shock protein 90 of Leishmania donovani. | Medical microbiology and immunology 20011101 |
| The Hsp90 inhibitor geldanamycin selectively sensitizes Bcr-Abl-expressing leukemia cells to cytotoxic chemotherapy. | Leukemia 20011001 |
| Degradation signals in ErbB-2 dictate proteasomal processing and immunogenicity and resist protection by cis glycine-alanine repeat. | Cellular immunology 20010915 |
| Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia. | Oncogene 20010913 |
| Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin. | The Journal of biological chemistry 20010907 |
| [Advances in antitumor activity of the hsp90 inhibitor geldanamycin]. | Yao xue xue bao = Acta pharmaceutica Sinica 20010901 |
| Hsp90 phosphorylation is linked to its chaperoning function. Assembly of the reovirus cell attachment protein. | The Journal of biological chemistry 20010831 |
| Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems. | Bioorganic & medicinal chemistry letters 20010820 |
| The molecular chaperone Hsp90 is required for signal transduction by wild-type Hck and maintenance of its constitutively active counterpart. | Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 20010801 |
| Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis. | The Annals of thoracic surgery 20010801 |
| Synergistic effects of geldanamycin and antitumor drugs. | Yao xue xue bao = Acta pharmaceutica Sinica 20010801 |
| Synthesis and characterization of HPMA copolymer-aminopropylgeldanamycin conjugates. | Journal of controlled release : official journal of the Controlled Release Society 20010706 |
| Dynamic changes in subcellular localization of mineralocorticoid receptor in living cells: in comparison with glucocorticoid receptor using dual-color labeling with green fluorescent protein spectral variants. | Molecular endocrinology (Baltimore, Md.) 20010701 |
| Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010701 |
| Geldanamycin inhibits NF-kappaB activation and interleukin-8 gene expression in cultured human respiratory epithelium. | American journal of respiratory cell and molecular biology 20010701 |
| Specific association of a set of molecular chaperones including HSP90 and Cdc37 with MOK, a member of the mitogen-activated protein kinase superfamily. | The Journal of biological chemistry 20010615 |
| Radicicol and geldanamycin prevent neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons. | Neuropharmacology 20010601 |
| Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. | Human molecular genetics 20010601 |
| The Drosophila Dpit47 protein is a nuclear Hsp90 co-chaperone that interacts with DNA polymerase alpha. | Journal of cell science 20010601 |
| Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin. | Cancer research 20010515 |
| Measurement of the novel antitumor agent 17-(allylamino)-17-demethoxygeldanamycin in human plasma by high-performance liquid chromatography. | Journal of chromatography. B, Biomedical sciences and applications 20010505 |
| Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus. | The Journal of biological chemistry 20010504 |
| LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family. | Bioorganic & medicinal chemistry letters 20010409 |
| Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. | Blood 20010401 |
| Hsp90 chaperone complexes are required for the activity and stability of yeast protein kinases Mik1, Wee1 and Swe1. | European journal of biochemistry 20010401 |
| Both the N- and C-terminal chaperone sites of Hsp90 participate in protein refolding. | European journal of biochemistry 20010401 |
| Inhibition of heat shock protein 90 function by ansamycins causes the morphological and functional differentiation of breast cancer cells. | Cancer research 20010401 |
| Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. | Genes to cells : devoted to molecular & cellular mechanisms 20010401 |
| Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones. | Cell stress & chaperones 20010401 |
| Geldanamycin and its analogue 17-allylamino-17-demethoxygeldanamycin lowers Bcr-Abl levels and induces apoptosis and differentiation of Bcr-Abl-positive human leukemic blasts. | Cancer research 20010301 |
| A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells. | Chemistry & biology 20010301 |
| Synergistic inhibition of the glucocorticoid receptor by radicicol and benzoquinone ansamycins. | Biological chemistry 20010301 |
| Androgen receptor signalling: comparative analysis of androgen response elements and implication of heat-shock protein 90 and 14-3-3eta. | Molecular and cellular endocrinology 20010227 |
| Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription. | Cancer research 20010215 |
| Opposite effects of the Hsp90 inhibitor Geldanamycin: induction of apoptosis in PC12, and differentiation in N2A cells. | FEBS letters 20010209 |
| Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. | The Journal of biological chemistry 20010202 |
| The inhibitory action of sodium arsenite on lipopolysaccharide-induced nitric oxide production in RAW 267.4 macrophage cells: a role of Raf-1 in lipopolysaccharide signaling. | Journal of immunology (Baltimore, Md. : 1950) 20010201 |
| Synthesis of the left-hand portion of geldanamycin using an anti glycolate aldol reaction. | Organic letters 20010125 |
| Hsp90 regulates p50(cdc37) function during the biogenesis of the activeconformation of the heme-regulated eIF2 alpha kinase. | The Journal of biological chemistry 20010105 |
| Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. | American journal of physiology. Heart and circulatory physiology 20010101 |
| Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010101 |
| Accelerated HER-2 degradation enhances ovarian tumor recognition by CTL. Implications for tumor immunogenicity. | Molecular and cellular biochemistry 20010101 |
| Differential regulation of CD3- and CD28-induced IL-2 and IFN-gamma production by a novel tyrosine kinase inhibitor XR774 from Cladosporium cf. cladosporioides. | International immunopharmacology 20010101 |
| The anti-proliferative effect of inhibitor of telomerase on cultured retinal pigment epithelial cells. | Journal of Tongji Medical University = Tong ji yi ke da xue xue bao 20010101 |
| The amount of estrogen receptor alpha increases after heat shock in a cholinergic cell line from the basal forebrain. | Neuroscience 20010101 |
| An evaluation of Hsp90 as a mediator of cortical patterning in Tetrahymena. | The Journal of eukaryotic microbiology 20010101 |
| Regulation of prostaglandin endoperoxide H synthase-2 induction by dioxin in rat hepatocytes: possible c-Src-mediated pathway. | Carcinogenesis 20001201 |
| Geldanamycin induces heat shock protein expression through activation of HSF1 in K562 erythroleukemic cells. | IUBMB life 19991001 |
| The benzoquinone ansamycin geldanamycin stimulates proteolytic degradation of focal adhesion kinase. | Molecular genetics and metabolism 19990101 |
| 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-mediated membrane translocation of c-Src protein kinase in liver WB-F344 cells. | Archives of toxicology 19990101 |
| Alterations in the growth factor signal transduction pathways and modulators of the cell cycle in endocervical cells from macaques exposed to TCDD. | Toxicology and applied pharmacology 19980801 |
| Interruption of estradiol signal transduction by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through disruption of the protein phosphorylation pathway in adipose tissues from immature and mature female rats. | Biochemical pharmacology 19980401 |
| Use of c-Src and c-Fos knockout mice for the studies on the role of c-Src kinase signaling in the expression of toxicity of TCDD. | Journal of biochemical and molecular toxicology 19980101 |
| Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway. | Molecular and cellular biology 19961001 |
| Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells. | Molecular endocrinology (Baltimore, Md.) 19960601 |
| p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2. | The Journal of biological chemistry 19960301 |
| Mechanisms controlling nitric oxide synthesis in osteoblasts. | Molecular and cellular endocrinology 19950101 |