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Trimebutine maleate

CAS No.:
34140-59-5
Catalog Number:
AG0038T5
Molecular Formula:
C26H33NO9
Molecular Weight:
503.5415
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$58
- +
5g
98%
In Stock USA
United States
$96
- +
Product Description
Catalog Number:
AG0038T5
Chemical Name:
Trimebutine maleate
CAS Number:
34140-59-5
Molecular Formula:
C26H33NO9
Molecular Weight:
503.5415
MDL Number:
MFCD00133874
IUPAC Name:
(Z)-but-2-enedioic acid;[2-(dimethylamino)-2-phenylbutyl] 3,4,5-trimethoxybenzoate
InChI:
InChI=1S/C22H29NO5.C4H4O4/c1-7-22(23(2)3,17-11-9-8-10-12-17)15-28-21(24)16-13-18(25-4)20(27-6)19(14-16)26-5;5-3(6)1-2-4(7)8/h8-14H,7,15H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI Key:
FSRLGULMGJGKGI-BTJKTKAUSA-N
SMILES:
OC(=O)/C=C\C(=O)O.CCC(c1ccccc1)(N(C)C)COC(=O)c1cc(OC)c(c(c1)OC)OC
NSC Number:
758900
Properties
Complexity:
585  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
503.216g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
503.548g/mol
Monoisotopic Mass:
503.216g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
132A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
End point determination of blending process for trimebutine tablets using principle component analysis (PCA) and partial least squares (PLS) regression. Archives of pharmacal research 20120901
[Potential severity of self-poisoning with trimebutine]. Presse medicale (Paris, France : 1983) 20120601
A case of trimebutine-induced anaphylaxis. Allergology international : official journal of the Japanese Society of Allergology 20111201
[Comparative study on irritable bowel syndrome treated with acupuncture and western medicine]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20110701
Trimebutine as a modulator of gastrointestinal motility. Archives of pharmacal research 20110601
Effects of trimebutine maleate on colonic motility through Ca²+-activated K+ channels and L-type Ca²+ channels. Archives of pharmacal research 20110601
[A medicine not so harmless as it appears: about an emergency case of acute voluntary poisoning with trimebutine (Debridat(®))]. Annales francaises d'anesthesie et de reanimation 20110101
Development of a novel combination tablet containing trimebutine maleate and mosapride citrate for the treatment of functional dyspepsia. International journal of pharmaceutics 20101115
Effectiveness of trimebutine maleate on modulating intestinal hypercontractility in a mouse model of postinfectious irritable bowel syndrome. European journal of pharmacology 20100625
[Prokinetics in childhood]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100601
A nitro-arginine derivative of trimebutine (NO2-Arg-Trim) attenuates pain induced by colorectal distension in conscious rats. Pharmacological research 20090501
Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101
Activation of peripheral opioid receptors has no effect on heart rate variability. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20080601
Inhibitory effects of ramosetron, a potent and selective 5-HT3-receptor antagonist, on conditioned fear stress-induced abnormal defecation and normal defecation in rats: comparative studies with antidiarrheal and spasmolytic agents. Journal of pharmacological sciences 20080201
[A randomized and case-control clinical study on trimebutine maleate in treating functional dyspepsia coexisting with diarrhea-dominant irritable bowel syndrome]. Zhonghua nei ke za zhi 20071101
Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials. Journal of gastroenterology and hepatology 20071001
Meta-analysis of the effects of prokinetic agents in patients with functional dyspepsia. Journal of gastroenterology and hepatology 20070301
[Drug treatment of irritable bowel syndrome: an unmet need]. Gastroenterologia y hepatologia 20070301
Pharmacokinetic and bioequivalence evaluation of two formulations of 100 mg trimebutine maleate (Recutin and Polybutin) in healthy male volunteers using the LC-MS/MS method. Clinica chimica acta; international journal of clinical chemistry 20070101
Increasing the effect of triptans in migraine. Lancet (London, England) 20061014
Rizatriptan vs. rizatriptan plus trimebutine for the acute treatment of migraine: a double-blind, randomized, cross-over, placebo-controlled study. Cephalalgia : an international journal of headache 20060701
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
The effect of trimebutine on the psychosocial adjustment to illness in the irritable bowel syndrome. Romanian journal of internal medicine = Revue roumaine de medecine interne 20060101
Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat. Life sciences 20051021
Pharmacokinetic study of trimebutine maleate in rabbit blood using in vivo microdialysis coupled to capillary electrophoresis. Journal of pharmaceutical and biomedical analysis 20050915
Novelty stress increases fecal pellet output in mongolian gerbils: effects of several drugs. Journal of pharmacological sciences 20050801
Determination of trimebutine in pharmaceuticals by differential pulse voltammetry at a glassy carbon electrode. Journal of pharmaceutical and biomedical analysis 20050715
Prokinetic agents in childen with poor appetite. Acta gastro-enterologica Belgica 20050101
Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats. Life sciences 20041203
Delayed reaction urticaria due to trimebutine. Allergy 20040701
H pylori infection and reflux oesophagitis. Gut 20040601
[Pharmacokinetics and bioequivalence of trimebutine dispersive tablet in healthy subjects]. Yao xue xue bao = Acta pharmaceutica Sinica 20040301
Establishing a comprehensive questionnaire for detecting drug-induced extrapyramidal symptoms. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20031001
Spectrophotometric and liquid chromatographic determination of trimebutine maleate in the presence of its degradation products. Journal of pharmaceutical and biomedical analysis 20030919
Quantitative determination of trimebutine maleate and its three metabolites in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021105
Preparation, characterization and taste-masking properties of polyvinylacetal diethylaminoacetate microspheres containing trimebutine. The Journal of pharmacy and pharmacology 20021001
The role of remote gut inflammation in duodenojejunal dysmotility. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20020401
[Prokinetics of gastrointestinal system; its newer aspects with regard to motillity stimulants]. Nihon rinsho. Japanese journal of clinical medicine 20020201
Oesophageal motility disorders. Lancet (London, England) 20020112
Efficacy of trimebutine therapy in patients with gastroesophageal reflux disease and irritable bowel syndrome. Hepato-gastroenterology 20020101
Allergic contact dermatitis due to trimebutine. Contact dermatitis 20010901
[Dysfunction of the Oddi's sphincter]. Gastroenterologie clinique et biologique 20010901
Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function. Alimentary pharmacology & therapeutics 20010801
Determination of trimebutine maleate in rat plasma and tissues by using capillary zone electrophoresis. Biomedical chromatography : BMC 20010601
[HPCE determination of trimebutine maleate in rat plasma and its pharmacokinetics]. Yao xue xue bao = Acta pharmaceutica Sinica 20010201
Effect of YNS-15P, a new alpha-2 adrenoceptor antagonist, on stress-stimulated colonic propulsion in rats. The Journal of pharmacology and experimental therapeutics 19981101
Trimebutine: mechanism of action, effects on gastrointestinal function and clinical results. The Journal of international medical research 19970101
Comparison of the effects of trimebutine and YM114 (KAE-393), a novel 5-HT3 receptor antagonist, on stress-induced defecation. European journal of pharmacology 19931207
Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells. British journal of pharmacology 19930901
Effect of trimebutine on K+ current in rabbit ileal smooth muscle cells. European journal of pharmacology 19930428
General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride. Arzneimittel-Forschung 19910601
Studies of metabolic pathways of trimebutine by simultaneous administration of trimebutine and its deuterium-labeled metabolite. Drug metabolism and disposition: the biological fate of chemicals 19890101
Properties