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Galanthamine

CAS No.:
357-70-0
Catalog Number:
AG0038S4
Molecular Formula:
C17H21NO3
Molecular Weight:
287.3535
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
50mg
99%
1 week
United States
$140
- +
100mg
99%
1 week
United States
$190
- +
Product Description
Catalog Number:
AG0038S4
Chemical Name:
Galanthamine
CAS Number:
357-70-0
Molecular Formula:
C17H21NO3
Molecular Weight:
287.3535
MDL Number:
MFCD00867189
IUPAC Name:
(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol
InChI:
InChI=1S/C17H21NO3/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17/h3-6,12,14,19H,7-10H2,1-2H3/t12-,14-,17-/m0/s1
InChI Key:
ASUTZQLVASHGKV-JDFRZJQESA-N
SMILES:
COc1ccc2c3c1O[C@@H]1[C@@]3(CCN(C2)C)C=C[C@@H](C1)O
UNII:
0D3Q044KCA
NSC Number:
759861
Properties
Complexity:
440  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
287.152g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
287.359g/mol
Monoisotopic Mass:
287.152g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
41.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.8  
Literature
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VAChT knock-down mice show normal prepulse inhibition but disrupted long-term habituation. Genes, brain, and behavior 20110601
In vitro antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricus species with fatty acid compositions and iron contents: a comparative study on the three most edible mushrooms. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110601
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Galantamine potentiates the protective effect of rofecoxib and caffeic acid against intrahippocampal Kainic acid-induced cognitive dysfunction in rat. Brain research bulletin 20110530
Possible role of cholinesterase inhibitors on memory consolidation following hypobaric hypoxia of rats. The International journal of neuroscience 20110501
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Effects of galantamine on cocaine use in chronic cocaine users. The American journal on addictions 20110501
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In Salvia miltiorrhiza, phenolic acids possess protective properties against amyloid β-induced cytotoxicity, and tanshinones act as acetylcholinesterase inhibitors. Environmental toxicology and pharmacology 20110501
Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide. Journal of pharmaceutical and biomedical analysis 20110428
Effect of fertilizers on galanthamine and metabolite profiles in Narcissus bulbs by 1H NMR. Journal of agricultural and food chemistry 20110413
Antioxidant and anticholinesterase constituents from the petroleum ether and chloroform extracts of Iris suaveolens. Phytotherapy research : PTR 20110401
Switching cholinesterase inhibitors in older adults with dementia. International psychogeriatrics 20110401
Metabolic profiling of 3-nitropropionic acid early-stage Huntington's disease rat model using gas chromatography time-of-flight mass spectrometry. Journal of proteome research 20110401
Synthesis of (-)-homogalanthamine from naltrexone. The Journal of organic chemistry 20110401
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Synthesis, biological evaluation and molecular modeling of novel triazole-containing berberine derivatives as acetylcholinesterase and β-amyloid aggregation inhibitors. Bioorganic & medicinal chemistry 20110401
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Galantamine may improve attention and speech in schizophrenia. Human psychopharmacology 20060301
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Post hoc comparison of daily rates of nausea and vomiting with once- and twice-daily galantamine from a double-blind, placebo-controlled, parallel-group, 6-month study. Clinical therapeutics 20060301
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Galantamine increases excitability of CA1 hippocampal pyramidal neurons. Neuroscience 20060101
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A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease. International journal of geriatric psychiatry 20060101
Galantamine: a cholinergic patch in the treatment of alcoholism: a randomized, placebo-controlled trial. Psychopharmacology 20060101
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Case of the month: rivastigmine (Exelon) toxicity with evidence of respiratory depression. Emergency medicine journal : EMJ 20060101
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Pharmacological and molecular enhancement of learning in aging and Alzheimer's disease. Journal of physiology, Paris 20060101
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Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20051201
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A case with cholinesterase inhibitor responsive asymmetric posterior cortical atrophy. Clinical neurology and neurosurgery 20051201
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Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population. International journal of geriatric psychiatry 20040601
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Management of patients with Alzheimer's disease plus cerebrovascular disease: 12-month treatment with galantamine. Dementia and geriatric cognitive disorders 20040101
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