Bctc
| Title | Journal |
|---|---|
| The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. | Toxicology and applied pharmacology 20171201 |
| Synthesis and pharmacological evaluation of novel N-aryl-3,4-dihydro-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxamides as TRPM8 antagonists. | Bioorganic & medicinal chemistry 20131101 |
| Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. | Laboratory investigation; a journal of technical methods and pathology 20120501 |
| Ocular dryness excites two classes of corneal afferent neurons implicated in basal tearing in rats: involvement of transient receptor potential channels. | Journal of neurophysiology 20120215 |
| Short isoforms of the cold receptor TRPM8 inhibit channel gating by mimicking heat action rather than chemical inhibitors. | The Journal of biological chemistry 20120127 |
| Use and limitations of three TRPV-1 receptor antagonists on smooth muscles of animals and man: a vote for BCTC. | European journal of pharmacology 20120105 |
| TRPM8 in mouse sperm detects temperature changes and may influence the acrosome reaction. | Journal of cellular physiology 20110601 |
| Enhanced insulin secretion and sensitization in diabetic mice on chronic treatment with a transient receptor potential vanilloid 1 antagonist. | Life sciences 20110314 |
| Pharmacological and functional properties of TRPM8 channels in prostate tumor cells. | Pflugers Archiv : European journal of physiology 20110101 |
| TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons. | Molecular neurodegeneration 20110101 |
| Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea. | Nature medicine 20101201 |
| Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath. | European journal of pharmacology 20100901 |
| Topical application of TRPM8 agonists accelerates skin permeability barrier recovery and reduces epidermal proliferation induced by barrier insult: role of cold-sensitive TRP receptors in epidermal permeability barrier homoeostasis. | Experimental dermatology 20100901 |
| Acid-induced CGRP release from the stomach does not depend on TRPV1 or ASIC3. | Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100601 |
| Pharmacologic antagonism of the oral aversive taste-directed response to capsaicin in a mouse brief access taste aversion assay. | The Journal of pharmacology and experimental therapeutics 20100201 |
| TRPV1 gene deficiency attenuates miniature EPSC potentiation induced by mannitol and angiotensin II in supraoptic magnocellular neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100120 |
| Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands. | Bioorganic & medicinal chemistry letters 20091201 |
| Involvement of afferent neurons in the pathogenesis of endotoxin-induced ileus in mice: role of CGRP and TRPV1 receptors. | European journal of pharmacology 20090801 |
| Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon. | American journal of physiology. Gastrointestinal and liver physiology 20090801 |
| Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. | American journal of physiology. Heart and circulatory physiology 20090601 |
| TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea. | The European journal of neuroscience 20090501 |
| TRPV1 is activated by both acidic and basic pH. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090107 |
| TRPM8, a versatile channel in human sperm. | PloS one 20090101 |
| Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels. | Molecular pain 20090101 |
| TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. | PloS one 20090101 |
| Human lung epithelial cells express a functional cold-sensing TRPM8 variant. | American journal of respiratory cell and molecular biology 20081001 |
| Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists. | Bioorganic & medicinal chemistry 20080915 |
| Studies on somnolence in the daytime caused by drugs used for neuropathic pain. | Journal of pharmacological sciences 20080701 |
| The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. | The Journal of clinical investigation 20080201 |
| Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries. | Behavioural pharmacology 20080201 |
| TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats. | American journal of physiology. Gastrointestinal and liver physiology 20080101 |
| The potential of transient receptor potential vanilloid type 1 channel modulators for the treatment of pain. | Journal of medicinal chemistry 20070531 |
| Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. | The Journal of physiology 20070515 |
| Differential involvement of TRPV1 receptors at the central and peripheral nerves in CFA-induced mechanical and thermal hyperalgesia. | The Journal of pharmacy and pharmacology 20070501 |
| Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig. | Cough (London, England) 20070101 |
| Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20061129 |
| Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. | Biochemical and biophysical research communications 20061110 |
| Design of potent, orally available antagonists of the transient receptor potential vanilloid 1. Structure-activity relationships of 2-piperazin-1-yl-1H-benzimidazoles. | Journal of medicinal chemistry 20060615 |
| Molecular identification and functional characterization of a temperature-sensitive transient receptor potential channel (TRPM8) from canine. | European journal of pharmacology 20060113 |
| Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats. | Neuropharmacology 20051201 |
| Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. | Molecular pharmacology 20051201 |
| Conservation of functional and pharmacological properties in the distantly related temperature sensors TRVP1 and TRPM8. | Molecular pharmacology 20050801 |
| Cloning and functional characterization of dog transient receptor potential vanilloid receptor-1 (TRPV1). | European journal of pharmacology 20050418 |
| 4-(2-Pyridyl)piperazine-1-benzimidazoles as potent TRPV1 antagonists. | Bioorganic & medicinal chemistry letters 20050201 |
| Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists. | Bioorganic & medicinal chemistry letters 20041115 |
| Vanilloid receptor TRPV1 antagonists as the next generation of painkillers. Are we putting the cart before the horse? | Journal of medicinal chemistry 20040520 |
| Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. | British journal of pharmacology 20040201 |
| 4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists. | Bioorganic & medicinal chemistry letters 20031020 |
| N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropathic pain. | The Journal of pharmacology and experimental therapeutics 20030701 |
| N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties. | The Journal of pharmacology and experimental therapeutics 20030701 |
| Cytochrome c interaction with membranes. Absorption and emission spectra and binding characteristics of iron-free cytochrome c. | European journal of biochemistry 19751201 |