Home Sulfos (2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid

(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid

CAS No.:
74863-84-6
Catalog Number:
AG0038G0
Molecular Formula:
C23H36N6O5S
Molecular Weight:
508.6341
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
98%
In Stock USA
United States
$350
- +
1g
98%
In Stock USA
United States
$1050
- +
Product Description
Catalog Number:
AG0038G0
Chemical Name:
(2R,4R)-1-[(2S)-5-[(diaminomethylidene)amino]-2-[(3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamido]pentanoyl]-4-methylpiperidine-2-carboxylic acid
CAS Number:
74863-84-6
Molecular Formula:
C23H36N6O5S
Molecular Weight:
508.6341
MDL Number:
MFCD23102419
IUPAC Name:
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid
InChI:
InChI=1S/C23H36N6O5S/c1-14-8-10-29(18(12-14)22(31)32)21(30)17(6-4-9-26-23(24)25)28-35(33,34)19-7-3-5-16-11-15(2)13-27-20(16)19/h3,5,7,14-15,17-18,27-28H,4,6,8-13H2,1-2H3,(H,31,32)(H4,24,25,26)/t14-,15?,17+,18-/m1/s1
InChI Key:
KXNPVXPOPUZYGB-IOVMHBDKSA-N
SMILES:
NC(=N)NCCC[C@@H](C(=O)N1CC[C@H](C[C@@H]1C(=O)O)C)NS(=O)(=O)c1cccc2c1NCC(C2)C
Properties
Complexity:
887  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
508.247g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
508.638g/mol
Monoisotopic Mass:
508.247g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
189A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3  
Literature
Title Journal
Use of argatroban and catheter-directed thrombolysis with alteplase in an oncology patient with heparin-induced thrombocytopenia with thrombosis. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20140501
Identification of old drugs as potential inhibitors of HIV-1 integrase - human LEDGF/p75 interaction via molecular docking. Journal of molecular modeling 20121201
Heparin-induced thrombocytopenia in essential thrombocytosis. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20121101
Bleeding risk factors associated with argatroban therapy in the critically ill. Journal of thrombosis and thrombolysis 20121101
Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome. Expert opinion on drug metabolism & toxicology 20121101
Treatment outcomes of heparin-induced thrombocytopenia in subarachnoid hemorrhage patients: a 4-year, retrospective single-center review. Neurocritical care 20121001
Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease. The American journal of pathology 20121001
Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful? American journal of clinical pathology 20121001
Direct thrombin inhibitors for management of heparin-induced thrombocytopenia in patients receiving renal replacement therapy: comparison of clinical outcomes. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120915
Translational success stories: development of direct thrombin inhibitors. Circulation research 20120914
Outcomes after heparin-induced thrombocytopenia in patients with Propaten vascular grafts. Annals of vascular surgery 20120801
Use of the chromogenic factor X assay in patients transitioning from argatroban to warfarin therapy. Pharmacotherapy 20120601
In vivo fluorescence imaging of atherosclerotic plaques with activatable cell-penetrating peptides targeting thrombin activity. Integrative biology : quantitative biosciences from nano to macro 20120601
Alternative anticoagulation during cardiovascular procedures in pediatric patients with heparin-induced thrombocytopenia. The journal of extra-corporeal technology 20120601
Thrombin activity associated with neuronal damage during acute focal ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120530
Thrombin inhibition profiles in healthy individuals and thrombophilic patients. Thrombosis and haemostasis 20120501
Recognition of heparin-induced thrombocytopenia and initiation of argatroban therapy after cardiothoracic surgery in the intensive care unit. The Journal of thoracic and cardiovascular surgery 20120501
Development of a fast and simple liquid chromatography-tandem mass spectrometry method for the quantitation of argatroban in patient plasma samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120415
Results of a consensus meeting on the use of argatroban in patients with heparin-induced thrombocytopenia requiring antithrombotic therapy - a European Perspective. Thrombosis research 20120401
Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency. The journal of obstetrics and gynaecology research 20120401
[Anesthesia for a hemodialysis patient with HIT undergoing CABG using argatroban]. Masui. The Japanese journal of anesthesiology 20120401
High-dose argatroban for treatment of heparin-induced thrombocytopenia with thrombosis: a case report and review of laboratory considerations. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120315
The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study. Stroke 20120301
The argatroban and tissue-type plasminogen activator stroke study: final results of a pilot safety study. Stroke 20120301
Argatroban anticoagulation for heparin induced thrombocytopenia in patients with ventricular assist devices. Minerva anestesiologica 20120301
Development and implementation of a comprehensive heparin-induced thrombocytopenia recognition and management protocol. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120201
Parenteral anticoagulants: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 20120201
Combined argatroban and anti-oxidative agents prevents increased vascular contractility to thrombin and other ligands after subarachnoid haemorrhage. British journal of pharmacology 20120101
Novel insights into the delayed vasospasm following subarachnoid haemorrhage: importance of proteinase signalling. British journal of pharmacology 20120101
A case of acute coronary artery occlusion associated with very rapid onset heparin-induced thrombosis without thrombocytopenia. Internal medicine (Tokyo, Japan) 20120101
Hitting back HIT. Annals of cardiac anaesthesia 20120101
Hemodialysis with a dialyzer loaded with argatroban may be performed in vivo without a systemic anticoagulant. Blood purification 20120101
Newer anticoagulants for the prevention of venous thromboembolism. The National medical journal of India 20120101
Old and new antithrombotic drugs in neonates and infants. Seminars in fetal & neonatal medicine 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
Identifying patient- and treatment-related factors related to amputation risk in cases of heparin-induced thrombocytopenia treated with argatroban. International angiology : a journal of the International Union of Angiology 20111201
Immobilization of anticoagulant-loaded liposomes on cell surfaces by DNA hybridization. Biomaterials 20111101
Water-soluble argatroban for antithrombogenic surface coating of tissue-engineered cardiovascular tissues. Journal of biomedical materials research. Part B, Applied biomaterials 20111101
Systemic administration of argatroban inhibits protease-activated receptor-1 expression in perihematomal tissue in rats with intracerebral hemorrhage. Brain research bulletin 20111010
Monitoring of the anticoagulants argatroban and lepirudin: a comparison of laboratory methods. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20111001
Direct thrombin inhibitors. British journal of clinical pharmacology 20111001
Effects of argatroban as an anticoagulant for intermittent veno-venous hemofiltration (IVVH) in patients at high risk of bleeding. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901
Heparin-induced thrombocytopenia type II because of heparin-coated polytetrafluoroethylene graft used to bypass. Annals of vascular surgery 20110801
Management of argatroban surrounding a lumbar puncture: a case report. American journal of hematology 20110801
Implementation of an individualized argatroban protocol in an academic medical center. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110715
Argatroban therapy in pediatric patients requiring nonheparin anticoagulation: an open-label, safety, efficacy, and pharmacokinetic study. Pediatric blood & cancer 20110701
Long-term animal implantation study of biotube-autologous small-caliber vascular graft fabricated by in-body tissue architecture. Journal of biomedical materials research. Part B, Applied biomaterials 20110701
Profiling of active thrombin in human blood by supramolecular complexes. Angewandte Chemie (International ed. in English) 20110627
Anticoagulation with argatroban for elective percutaneous coronary intervention: population pharmacokinetics and pharmacokinetic-pharmacodynamic relationship of coagulation parameters. Journal of clinical pharmacology 20110601
[Diagnosis and treatment of heparin-induced thrombocytopenia]. Deutsche medizinische Wochenschrift (1946) 20110501
Argatroban for elective percutaneous coronary intervention: the ARG-E04 multi-center study. International journal of cardiology 20110414
Practical viewpoints on the diagnosis and management of heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20110401
[Interventional lung assist membrane ventilator. Successful use despite heparin-induced thrombocytopenia type II]. Der Anaesthesist 20110301
Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia. American journal of hematology 20110301
Use of argatroban as a procedural and bridging anticoagulant in a patient undergoing carotid endarterectomy with concomitant atrial fibrillation. The Annals of pharmacotherapy 20110301
Argatroban therapy using enzymatic anti-factor IIa monitoring. The Annals of pharmacotherapy 20110301
[Efficacy of regional administration of urokinase and argatroban via small saphenous vein catheter for treatment of acute deep venous thrombosis in the lower limb]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110301
Venous limb gangrene and fatal hemorrhage: adverse consequences of HIT 'overdiagnosis' in a patient with antiphospholipid syndrome. American journal of hematology 20110201
Thrombosis prophylaxis in critically ill patients. Wiener medizinische Wochenschrift (1946) 20110201
Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children. Wiener medizinische Wochenschrift (1946) 20110201
[Synthetic protease inhibitors for the treatment of DIC]. Rinsho byori. The Japanese journal of clinical pathology 20110201
Pharmacokinetic and pharmacodynamic basis for effective argatroban dosing in pediatrics. Journal of clinical pharmacology 20110101
A patient with 'spontaneous' heparin-induced thrombocytopenia and thrombosis after undergoing knee replacement. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20110101
A randomized, open-label pilot study comparing desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis: PREVENT-HIT Study. American journal of therapeutics 20110101
Hypereosinophilic syndrome with cardiac involvement in a pregnant patient with multiple sclerosis. Texas Heart Institute journal 20110101
An optimized method to assess in vivo efficacy of antithrombotic drugs using optical coherence tomography and a modified Doppler flow system. Journal of pharmacological and toxicological methods 20110101
Argatroban 'reversal' is caused by nonphysiologic stimulation of coagulation, not activated factor VII. Journal of cardiothoracic and vascular anesthesia 20101201
Carbon monoxide releasing molecule-2 enhances coagulation and diminishes fibrinolytic vulnerability in plasma exposed to heparin or argatroban. Anesthesia and analgesia 20101201
Comparison of bivalirudin and argatroban for the management of heparin-induced thrombocytopenia. Pharmacotherapy 20101201
Extracorporeal membrane oxygenation bridging to lung transplant complicated by heparin-induced thrombocytopenia. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20101201
Argatroban administration reduces leukocyte adhesion and improves capillary perfusion within the intestinal microcirculation in experimental sepsis. Thrombosis and haemostasis 20101101
[Concept of branch atheromatous disease (BAD) and its clinical significance]. Rinsho shinkeigaku = Clinical neurology 20101101
Difficult management of anticoagulation with argatroban in a patient undergoing on-pump cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20101001
Safety and efficacy of the argatroban therapy during the early post-cardiac surgery period. Journal of thrombosis and thrombolysis 20101001
Pharmacotherapy in the critically ill obese patient. Critical care clinics 20101001
Pharmacology of argatroban. Expert review of hematology 20101001
Low dose of argatroban saline flushes anticoagulation in hemodialysis patients with high risk of bleeding. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100801
Argatroban and renal replacement therapy in a morbidly obese patient with heparin-induced thrombocytopenia: a case report. Thrombosis research 20100801
Treatment with argatroban in one haemodialysed patient with a heparin-induced thrombocytopenia and thrombotic complications. Internal and emergency medicine 20100801
Serious acute coronary thrombosis associated with heparin-induced thrombocytopenia in off-pump coronary artery bypass grafting. Interactive cardiovascular and thoracic surgery 20100801
Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin. Thrombosis and haemostasis 20100801
Fondaparinux therapy in a hemodialysis patient with heparin-induced thrombocytopenia type II. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100701
[Heparin-induced thrombocytopenia after on-pump coronary artery bypass grafting]. Kyobu geka. The Japanese journal of thoracic surgery 20100601
An overview of heparin-induced thrombocytopenia. Journal of pharmacy practice 20100601
The direct thrombin inhibitors (argatroban, bivalirudin and lepirudin) and the indirect Xa-inhibitor (danaparoid) increase fibrin network porosity and thus facilitate fibrinolysis. Thrombosis and haemostasis 20100501
Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis. Transfusion 20100401
Argatroban as a substitute of heparin during cardiopulmonary bypass: a safe alternative? Interactive cardiovascular and thoracic surgery 20100401
The direct thrombin inhibitor argatroban effectively prevents cardiac catheter thrombosis in vitro. Thrombosis and haemostasis 20100401
Rationale and design of the PREVENT-HIT study: a randomized, open-label pilot study to compare desirudin and argatroban in patients with suspected heparin-induced thrombocytopenia with or without thrombosis. Clinical therapeutics 20100401
Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20100301
Laboratory monitoring of new anticoagulants. American journal of hematology 20100301
Thrombolytic therapy and thrombectomy in phlegmasia cerulea dolens. The journal of the Royal College of Physicians of Edinburgh 20100301
Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. Journal of medicinal chemistry 20100225
Review: recent advances in argatroban-warfarin transition in patients with heparin-induced thrombocytopenia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100201
Heparin-induced thrombocytopenia in two patients undergoing abdominal aortic aneurysm surgery. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20100201
Inhibition of thrombin action ameliorates insulin resistance in type 2 diabetic db/db mice. Endocrinology 20100201
Heparin-induced thrombocytopenia and cardiac surgery. Current opinion in anaesthesiology 20100201
Simultaneous use of argatroban and heparin during cardiopulmonary bypass. Asian cardiovascular & thoracic annals 20100201
Impact of renal function on argatroban therapy during percutaneous coronary intervention. Journal of thrombosis and thrombolysis 20100101
Anticoagulation with argatroban in a parturient with heparin-induced thrombocytopenia. International journal of obstetric anesthesia 20100101
An evaluation of monitoring possibilities of argatroban using rotational thromboelastometry and activated partial thromboplastin time. Acta anaesthesiologica Scandinavica 20100101
Autologous small-caliber 'biotube' vascular grafts with argatroban loading: a histomorphological examination after implantation to rabbits. Journal of biomedical materials research. Part B, Applied biomaterials 20100101
Quantitation of argatroban in plasma using liquid chromatography electrospray tandem mass spectrometry (UPLC-ESI-MS/MS). Methods in molecular biology (Clifton, N.J.) 20100101
Argatroban therapy for heparin-induced thrombocytopenia in ICU patients with multiple organ dysfunction syndrome: a retrospective study. Critical care (London, England) 20100101
Argatroban in the management of heparin-induced thrombocytopenia. Vascular health and risk management 20100101
Thrombin inhibition in subarachnoid hemorrhage. Neurosurgery 20091201
[Heparin-induced thrombocytopenia type II with thrombosis in an intensive care patient: therapy management using the direct thrombin inhibitor argatroban]. Der Anaesthesist 20091101
RapidTEG observation suggests activation of factor VII may overcome argatroban-induced coagulopathy. Journal of cardiothoracic and vascular anesthesia 20091001
Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits. Atherosclerosis 20091001
Heparin-induced thrombocytopenia with multiple organized thrombi accompanied by unusual cholesterin deposition: autopsy case after long-term follow up. Pathology international 20091001
[Anticoagulation in critically ill patient]. Wiener medizinische Wochenschrift (1946) 20091001
Heparin induced thrombocytopenia and re-thrombosis associated with warfarin and fondaparinux in a child. Pediatric blood & cancer 20090901
Argatroban dosage requirements and outcomes in intensive care versus non-intensive care patients. Pharmacotherapy 20090901
[Anesthetic management for a patient with heparin-induced thrombocytopenia (HIT) undergoing off-pump coronary bypass surgery using argatroban, a direct thrombin inhibitor]. Masui. The Japanese journal of anesthesiology 20090901
A comparison of direct thrombin inhibitors in the treatment of Heparin-Induced Thrombocytopenia: a single institution experience. Journal of thrombosis and thrombolysis 20090801
Anticoagulation with the direct thrombin inhibitor argatroban in patients presenting with acute coronary syndromes. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20090801
Extremely low doses of lepirudin in a patient with heparin-induced thrombocytopenia, high bleeding risk and renal insufficiency. British journal of haematology 20090801
HeartMate II implantation in patients with heparin-induced thrombocytopenia type II. The Annals of thoracic surgery 20090801
Clinical investigation in ACS and PCI: shooting in the dark at a moving target. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20090801
Anterior spinal artery as a collateral channel in patients with acute bilateral vertebral artery occlusions. Two case reports. Neurologia medico-chirurgica 20090801
Stabilization of the E* form turns thrombin into an anticoagulant. The Journal of biological chemistry 20090724
Dosing patterns and outcomes in African American, Asian, and Hispanic patients with heparin-induced thrombocytopenia treated with argatroban. Journal of thrombosis and thrombolysis 20090701
Influence of antithrombin and argatroban on disseminated intravascular coagulation parameters in a patient with septic shock. Thrombosis research 20090701
INR matters: a case on managing argatroban for bridging oral anticoagulation in a patient with heparin induced thrombocytopenia type II after mechanical heart valve replacement. Thrombosis research 20090601
Argatroban for anticoagulation in continuous renal replacement therapy. Critical care medicine 20090601
The effect of argatroban on activated protein C resistance. American journal of clinical pathology 20090601
Argatroban and bivalirudin compared to unfractionated heparin in preventing thrombus formation on mechanical heart valves. Results of an in-vitro study. Thrombosis and haemostasis 20090601
Heparin-induced thrombocytopenia. A contemporary clinical approach to diagnosis and management. Chest 20090601
[Clinical observation of heparin-induced thrombocytopenia]. Zhonghua yi xue za zhi 20090526
Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats. Stroke 20090401
Argatroban and catheter-directed thrombolysis with alteplase for limb- and graft-threatening thromboses in a patient with a history of HIT. American journal of hematology 20090401
[A study of the dosage of argatroban for anticoagulation effect in the patients undergoing high volume hemofiltration]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090401
Comparison of activated clotting times obtained using Hemochron and Medtronic analysers in patients receiving anti-thrombin therapy during cardiac catheterisation. Thrombosis and haemostasis 20090301
A report of outcomes after orthotopic liver transplant with allografts from heparin antibody-positive donors. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20090301
[Argatroban treatment of heparin-induced immune-mediated thrombocytopenia]. Ugeskrift for laeger 20090216
[Heparin-induced thrombocytopenia]. Ugeskrift for laeger 20090216
The effect of ex vivo anticoagulants on whole blood platelet aggregation. Platelets 20090201
84-year-old woman with hemodialysis-associated shortness of breath. Mayo Clinic proceedings 20090201
Heparin-induced thrombocytopenia: what clinicians need to know. Thrombosis and haemostasis 20090201
[Use of argatroban during cardiopulmonary bypass for atrial septal defect with heparin induced thrombocytopenia after introduction of dialysis]. Kyobu geka. The Japanese journal of thoracic surgery 20090201
Argatroban for anticoagulation in continuous renal replacement therapy. Critical care medicine 20090101
'Drug dosing in the intensive care unit: the critically ill are a special population too'. Critical care medicine 20090101
Effects of critical illness and organ failure on therapeutic argatroban dosage requirements in patients with suspected or confirmed heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20090101
Weight-based argatroban dosing nomogram for treatment of heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20090101
Argatroban therapy in heparin-induced thrombocytopenia. AACN advanced critical care 20090101
Reducing harm associated with anticoagulation: practical considerations of argatroban therapy in heparin-induced thrombocytopenia. Drug safety 20090101
Use of argatroban during multi-organ procurement: pharmacokinetics and sequelae in recipient of transplanted liver. Clinical transplantation 20090101
Argatroban: a review of its use in the management of heparin-induced thrombocytopenia. American journal of cardiovascular drugs : drugs, devices, and other interventions 20090101
Heparin-induced thrombocytopenia: when a low platelet count is a mandate for anticoagulation. Hematology. American Society of Hematology. Education Program 20090101
Argatroban enhances fibrinolysis by differential inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor and factor XIII. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20081201
Successful use of argatroban during the third trimester of pregnancy: case report and review of the literature. Pharmacotherapy 20081201
Risk factors for major bleeding in patients with heparin-induced thrombocytopenia treated with argatroban: a retrospective study. Journal of cardiovascular pharmacology 20081201
Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. Blood 20081115
Heparin-induced thrombocytopenia (HIT) causing pulmonary emboli during coronary intervention. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20081115
The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms. Breast cancer research and treatment 20081101
Thrombin enhances the production of monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 in cultured rat glomerular epithelial cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20081101
Use of Argatroban for anticoagulation during cardiopulmonary bypass in a patient with heparin allergy. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20081101
Management of uremic patients with heparin-induced thrombocytopenia requiring hemodialysis. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20081001
Complete salvage of impending free flap failure in heparin induced thrombocytopenia by emergent institution of therapy with argatroban. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20081001
Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia. British journal of haematology 20081001
[Three cases of small brain infarction in the lateral wall of the fourth ventricle presenting with paroxysmal positional vertigo and vomiting]. Rinsho shinkeigaku = Clinical neurology 20081001
Factor VIIa inhibitors: target hopping in the serine protease family using X-ray structure determination. Bioorganic & medicinal chemistry letters 20080815
Inhibition of osteopontin dependent carcinogenesis. Journal of cancer research and clinical oncology 20080801
Argatroban use in heparin-induced thrombocytopenia. Expert opinion on pharmacotherapy 20080801
Therapeutic effect of argatroban on rheumatoid vasculitis with antiphosphatidylserine-prothrombin complex antibody. Archives of dermatology 20080801
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Addendum. Chest 20080801
Influence of continuous veno-venous hemofiltration on argatroban clearance in a patient with septic shock. Intensive care medicine 20080701
Efficacy and safety of argatroban in patients with heparin induced thrombocytopenia undergoing endovascular intervention for peripheral arterial disease. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20080701
Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effect on coagulation factor testing. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20080701
What is the optimal anticoagulation level with argatroban during percutaneous coronary intervention? Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080701
Interaction between thrombin mutant W215A/E217A and direct thrombin inhibitor. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080701
Effect of body mass index on Argatroban therapy during percutaneous coronary intervention. Journal of thrombosis and thrombolysis 20080601
Influence of direct thrombin inhibitor argatroban on coagulation assays in healthy individuals, patients under oral anticoagulation therapy and patients with liver dysfunction. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20080601
Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 20080601
Argatroban in short-term percutaneous ventricular assist subsequent to heparin-induced thrombocytopenia. The journal of extra-corporeal technology 20080601
Heparins, low-molecular-weight heparins, and pentasaccharides: use in the older patient. Cardiology clinics 20080501
New anticoagulant agents: direct thrombin inhibitors. Cardiology clinics 20080501
Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices. The Annals of thoracic surgery 20080501
Argatroban as a primary or secondary postoperative anticoagulant in patients implanted with ventricular assist devices. Invited commentary. The Annals of thoracic surgery 20080501
Bivalirudin. Thrombosis and haemostasis 20080501
Heparin-induced thrombocytopenia: a review of current pharmacologic treatment. Connecticut medicine 20080501
Efficacy and safety of argatroban with or without glycoprotein IIb/IIIa inhibitor in patients with heparin induced thrombocytopenia undergoing percutaneous coronary intervention for acute coronary syndrome. Journal of thrombosis and thrombolysis 20080401
Argatroban therapy in patients with hepatic and renal impairment. European journal of anaesthesiology 20080401
[Heparin induced thrombocytopenia and anticoagulation in renal replacemant therapy]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20080401
Prolonged half-life of argatroban in patients with renal dysfunction and antiphospholipid antibody syndrome being treated for heparin-induced thrombocytopenia. American journal of hematology 20080301
Reduced argatroban doses after coronary artery bypass graft surgery. The Annals of pharmacotherapy 20080301
Considerations for drug dosing post coronary artery bypass graft surgery. The Annals of pharmacotherapy 20080301
Standardizing the management of heparin-induced thrombocytopenia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080215
The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update. Seminars in thrombosis and hemostasis 20080201
Argatroban therapy in patients with coronary artery disease and heparin-induced thrombocytopenia. Cardiology 20080101
Visual evaluation of blood coagulation during mural thrombogenesis under high shear blood flow. Thrombosis research 20080101
Complete 1H and 13C assignments of (21R) and (21S) diastereomers of argatroban. Magnetic resonance in chemistry : MRC 20080101
Heparin-induced thrombocytopenia complicating hemodialysis. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20080101
Thrombelastography in a patient with heparin-induced thrombocytopenia treated with argatroban. Anesthesia and analgesia 20080101
[Patient with heparin-induced thrombocytopenia type II and implanted left ventricular assist device]. Der Anaesthesist 20080101
Fondaparinux versus direct thrombin inhibitor therapy for the management of heparin-induced thrombocytopenia (HIT)--bridging the River Coumarin. Thrombosis and haemostasis 20080101
Ultrasound-guided supraclavicular block in a patient anticoagulated with argatroban. Pain practice : the official journal of World Institute of Pain 20080101
Comparison of the ecarin chromogenic assay and different aPTT assays for the measurement of argatroban concentrations in plasma from healthy individuals and from coagulation factor deficient patients. Thrombosis research 20080101
Prediction of the therapeutic index of marketed anti-coagulants and anti-platelet agents by guinea pig models of thrombosis and hemostasis. Thrombosis research 20080101
Argatroban anticoagulation in renal dysfunction: a literature analysis. Nephron. Clinical practice 20080101
Argatroban anticoagulation in intensive care patients: effects of heart failure and multiple organ system failure. Journal of intensive care medicine 20080101
Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia. Congenital heart disease 20080101
Treatment of intracardiac thrombi with argatroban. Acute cardiac care 20080101
Management of a pediatric patient on the Berlin Heart Excor ventricular assist device with argatroban after heparin-induced thrombocytopenia. ASAIO journal (American Society for Artificial Internal Organs : 1992) 20080101
The use of alternative anti-coagulation strategies for a nocturnal home hemodialysis patient with heparin-induced thrombocytopenia. CANNT journal = Journal ACITN 20080101
Thrombin enhances glioma growth. Acta neurochirurgica. Supplement 20080101
Inhibition of thrombin generation in recalcified plasma. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20071201
Catheter-directed thrombolysis of acute lower extremity arterial thrombosis in a patient with heparin-induced thrombocytopenia. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20071201
[Are new anticoagulants better?]. Investigacion clinica 20071201
Development of self-expandable covered stents. Journal of biomedical materials research. Part B, Applied biomaterials 20071101
Anti-Helicobacter pylori and thrombin inhibitory components from Chinese dragon's blood, Dracaena cochinchinensis. Journal of natural products 20071001
Seizures, headache and thrombocytopenia: diagnosis and treatment do not always come in a standard sequence. Internal and emergency medicine 20071001
Argatroban therapy for heparin-induced thrombocytopenia in acutely ill patients. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20071001
[Heparin-induced thrombocytopenia]. Revista espanola de cardiologia 20071001
A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 20071001
Influence of argatroban on coagulation parameters in heparin-induced thrombocytopenia patients after cardiothoracic surgery. Journal of thrombosis and haemostasis : JTH 20070901
Heparin induced thrombocytopenia: diagnosis and management update. Postgraduate medical journal 20070901
Percutaneous coronary interventions in patients with heparin-induced thrombocytopenia. Current cardiology reports 20070901
Heparin induced thrombocytopenia: pathogenetic, clinical, diagnostic and therapeutic aspects. Cardiovascular & hematological disorders drug targets 20070901
Argatroban anticoagulation in obese versus nonobese patients: implications for treating heparin-induced thrombocytopenia. Journal of clinical pharmacology 20070801
Heparin-induced thrombocytopenia II-induced critical limb ischaemia treated with urokinase and argatroban. Thrombosis and haemostasis 20070801
Involvement of thrombin and mitogen-activated protein kinase pathways in hemorrhagic brain injury. Experimental neurology 20070701
Argatroban in extracorporeal membrane oxygenation. Artificial organs 20070601
Efficacy of anti-coagulant treatment with argatroban on cardioembolic stroke. Journal of neurology 20070501
Argatroban anticoagulation in critically ill patients. The Annals of pharmacotherapy 20070501
Argatroban anticoagulation for renal replacement therapy in patients with heparin-induced thrombocytopenia after cardiovascular surgery. The Journal of thoracic and cardiovascular surgery 20070501
Heparin-induced thrombocytopenia and thrombosis. American journal of orthopedics (Belle Mead, N.J.) 20070501
Assessing nonlinearity in compartment models via the relative curvature measure. Journal of pharmacokinetics and pharmacodynamics 20070401
Heparin-induced thrombocytopenia in intensive care patients. Critical care medicine 20070401
Heparin-induced thrombocytopenia: treatment options and special considerations. Pharmacotherapy 20070401
Impact of smart infusion technology on administration of anticoagulants (unfractionated Heparin, Argatroban, Lepirudin, and Bivalirudin). The American journal of cardiology 20070401
Essentials of anticoagulation in hemodialysis. Hemodialysis international. International Symposium on Home Hemodialysis 20070401
Argatroban for anticoagulation in pediatric patients with heparin-induced thrombocytopenia requiring extracorporeal life support. Journal of pediatric hematology/oncology 20070401
Differential effects of direct thrombin inhibitors and antithrombin-dependent anticoagulants on the dynamics of clot formation. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070301
Platelet activity, coagulation, and fibrinolysis during exercise in healthy males: effects of thrombin inhibition by argatroban and enoxaparin. Arteriosclerosis, thrombosis, and vascular biology 20070201
[Two surgical case reports showing atypical heparin-induced thrombocytopenia]. Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20070201
Alternative anticoagulation management strategies for the patient with heparin-induced thrombocytopenia undergoing cardiac surgery. Journal of cardiothoracic and vascular anesthesia 20070201
[Bilateral cerebellar infarction caused by intracranial dissection of the vertebral artery after long periods of 'Shiatsu']. No to shinkei = Brain and nerve 20070201
Argatroban for anticoagulation during cardiac surgery. European journal of haematology 20070201
Hydroxyethyl starch enhances argatroban-mediated decreases in clot propagation and strength by diminishing thrombin-fibrinogen interactions. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20070101
Direct thrombin inhibition during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. Expert review of cardiovascular therapy 20070101
Anticoagulation options for patients with heparin-induced thrombocytopenia requiring renal support in the intensive care unit. Contributions to nephrology 20070101
Argatroban anticoagulation for heparin-induced thrombocytopenia in elderly patients. Drugs & aging 20070101
Heparin-induced thrombocytopenia: a general review. Journal of infusion nursing : the official publication of the Infusion Nurses Society 20070101
A case series describing the use of argatroban in patients on extracorporeal circulation. ASAIO journal (American Society for Artificial Internal Organs : 1992) 20070101
Argatroban therapy in women with heparin-induced thrombocytopenia. Journal of women's health (2002) 20070101
Anticoagulation for acute coronary syndromes: from heparin to direct thrombin inhibitors. Reviews in cardiovascular medicine 20070101
Direct thrombin inhibitors: alternatives to heparin. Vascular 20070101
Heparin-induced thrombocytopenia in the critical care setting: diagnosis and management. Critical care medicine 20061201
Effect of renal function on argatroban therapy in heparin-induced thrombocytopenia. Journal of thrombosis and thrombolysis 20061201
Heparin-induced thrombocytopenia: advances in diagnosis and treatment. Critical care nurse 20061201
Prolonged anticoagulation after discontinuation of argatroban and warfarin therapy in an obese patient with heparin-induced thrombocytopenia. Pharmacotherapy 20061201
Heparin-induced thrombocytopenia without thrombosis: an evidence-based review of current literature. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 20061201
[Argatroban]. Nihon rinsho. Japanese journal of clinical medicine 20061028
Anticoagulation strategies for treatment of ischemic stroke and antiphospholipid syndrome: case report and review of the literature. Pharmacotherapy 20061001
Systemic anticoagulation with argatroban during arteriovenous dialysis graft thrombolysis. Journal of vascular and interventional radiology : JVIR 20061001
Flavonoids inhibit the amidolytic activity of human thrombin. Biochimie 20060901
Anticoagulation with argatroban in patients with heparin-induced thrombocytopenia antibodies after cardiovascular surgery with cardiopulmonary bypass: first results from the ARG-E03 trial. The Journal of thoracic and cardiovascular surgery 20060901
Argatroban tPA stroke study: study design and results in the first treated cohort. Archives of neurology 20060801
[Two cases of heparin-induced thrombocytopenia (HIT) and a review of the literature]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20060801
On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system. Analytical chemistry 20060715
Heparin-induced thrombocytopenia and cardiovascular diseases. American heart journal 20060701
Argatroban, bivalirudin, and lepirudin do not decrease clot propagation and strength as effectively as heparin-activated antithrombin in vitro. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20060601
Recognition and management of heparin-induced thrombocytopenia in pediatric cardiopulmonary bypass patients. The Annals of thoracic surgery 20060601
Thrombotic end point for assessing argatroban therapy for heparin-induced thrombocytopenia: learning from secondary analyses of prospective studies. Chest 20060601
Effects of argatroban therapy, demographic variables, and platelet count on thrombotic risks in heparin-induced thrombocytopenia. Chest 20060601
Argatroban: update. American heart journal 20060601
[Pharmacotherapy: argatroban--alternative to heparin in case of heparin-induced thrombocytopenia type II (HIT II)]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20060601
[Advanced medical therapy in patients with acute ischemic stroke]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060601
Heparin-induced thrombocytopenia in a pediatric patient receiving extracorporeal support and treated with argatroban. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060501
Argatroban dosing of patients with heparin-induced thrombocytopenia and an elevated aPTT due to antiphospholipid antibody syndrome. The Annals of pharmacotherapy 20060501
Argatroban therapy in heparin-induced thrombocytopenia with hepatic dysfunction. Chest 20060501
Thrombin-induced delayed injury involves multiple and distinct signaling pathways in the cerebral cortex and the striatum in organotypic slice cultures. Neurobiology of disease 20060401
[Argatroban: pharmacological properties and anaesthesiological aspects]. Der Anaesthesist 20060401
Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia. Pharmacotherapy 20060401
Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro. Journal of thrombosis and haemostasis : JTH 20060401
Argatroban: a direct thrombin inhibitor with reliable and predictable anticoagulant actions. Drugs of today (Barcelona, Spain : 1998) 20060401
Cardiac surgery in a patient with heparin-induced thrombocytopenia--cautions with use of the direct thrombin inhibitor, argatroban. Connecticut medicine 20060401
[Argatroban]. Deutsche medizinische Wochenschrift (1946) 20060331
Safety and efficacy of argatroban in patients with heparin-induced thrombocytopenia. Current hematology reports 20060301
A new method for assessment of an anti-5HT(2A) agent, sarpogrelate hydrochloride, on platelet aggregation. Journal of thrombosis and haemostasis : JTH 20060201
Treatment of heparin-induced thrombocytopenia in cardiovascular patients. Expert opinion on pharmacotherapy 20060201
Successful recovery after an overdose of argatroban. The Annals of pharmacotherapy 20060201
[A case of heparin-induced thrombocytopenia associated with unexpected excessive argatroban anticoagulation after abdominal aortic aneurysm resection]. Masui. The Japanese journal of anesthesiology 20060201
Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. World journal of gastroenterology 20060107
Argatroban, a direct thrombin inhibitor for heparin-induced thrombocytopaenia: present and future perspectives. Expert opinion on pharmacotherapy 20060101
The cost-effectiveness of argatroban treatment in heparin-induced thrombocytopenia: the effect of early versus delayed treatment. Cardiology in review 20060101
Argatroban anticoagulation in pediatric patients: a literature analysis. Journal of pediatric hematology/oncology 20060101
Heparin-induced thrombocytopenia and cardiovascular patients: recognition and treatment. Progress in cardiovascular nursing 20060101
Argatroban for suspected heparin-induced thrombocytopenia: contemporary experience at a large teaching hospital. Journal of intensive care medicine 20060101
When heparin causes thrombosis: significance, recognition, and management of heparin-induced thrombocytopenia in dialysis patients. Seminars in dialysis 20060101
Heparin-induced thrombocytopenia in patients administered heparin solely for hemodialysis. Renal failure 20060101
Treatment of heparin-induced thrombocytopenia: a practical argatroban dosing protocol for nurses. Journal of infusion nursing : the official publication of the Infusion Nurses Society 20060101
3,6-disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa. Journal of medicinal chemistry 20051201
Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia. Pharmacotherapy 20051201
Heparin-induced thrombocytopenia from venous thromboembolism treatment. Journal of internal medicine 20051201
Comment: extensive prolongation of aPTT with argatroban in an elderly patient with improving renal function, normal hepatic enzymes, and metastatic lung cancer. The Annals of pharmacotherapy 20051101
Differences in the clinically effective molar concentrations of four direct thrombin inhibitors explain their variable prothrombin time prolongation. Thrombosis and haemostasis 20051101
Mechanism of antithrombotic effect of heparin and antithrombin in balloon-injured arteries. Life sciences 20051007
Argatroban-coupled Affi-Gel matrix for the purification of thrombin from plasma. Biotechnology and applied biochemistry 20051001
Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy. The Annals of pharmacotherapy 20051001
Presence of direct thrombin inhibitors can affect the results and interpretation of lupus anticoagulant testing. American journal of clinical pathology 20051001
Argatroban and lepirudin requirements in a 6-year-old patient with heparin-induced thrombocytopenia. Pharmacotherapy 20051001
Argatroban and lepirudin: clinical trials to clinical practice. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20051001
A comparison of lepirudin and argatroban outcomes. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20051001
[A case of anterior cerebral artery dissection causing enlargement of infarction]. Rinsho shinkeigaku = Clinical neurology 20051001
Direct thrombin inhibitors. The New England journal of medicine 20050908
The role of thrombin in gliomas. Journal of thrombosis and haemostasis : JTH 20050901
Collaborative study on monitoring methods to determine direct thrombin inhibitors lepirudin and argatroban. Journal of thrombosis and haemostasis : JTH 20050901
Acute subdural hematoma: new model delineation and effects of coagulation inhibitors. Neurosurgery 20050901
Heparin and other rapidly acting anticoagulants. Seminars in vascular surgery 20050901
Cardiopulmonary bypass using argatroban as an anticoagulant for a 6.0-kg pediatric patient. The journal of extra-corporeal technology 20050901
Successful therapy with argatroban for superior mesenteric vein thrombosis in a patient with congenital antithrombin deficiency. European journal of haematology 20050801
New antithrombotics in the prevention of thromboembolic disease. European journal of internal medicine 20050801
Scanning electron microscopical observations of two novel hemostatic polymers. Journal of thrombosis and haemostasis : JTH 20050701
Thrombin inhibitor reduces leukocyte-endothelial cell interactions and vascular leakage after scatter laser photocoagulation. Investigative ophthalmology & visual science 20050701
Toxicity of argatroban overdose in a 65-year-old man. American journal of hematology 20050701
Transitioning from argatroban to warfarin therapy in patients with heparin-induced thrombocytopenia. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20050701
[Heparin-induced thrombocytopenia (HIT): pathogenesis, laboratory test, and treatment]. Rinsho byori. The Japanese journal of clinical pathology 20050701
Evolving management strategies for heparin-induced thrombocytopenia. Seminars in hematology 20050701
Effect of argatroban on the activated partial thromboplastin time: a comparison of 21 commercial reagents. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20050601
Extensive prolongation of aPTT with argatroban in an elderly patient with improving renal function, normal hepatic enzymes, and metastatic lung cancer. The Annals of pharmacotherapy 20050601
Direct thrombin inhibitors: pharmacology and clinical relevance. Anaesthesia 20050601
[Nontraumatic arterial dissection of the anterior cerebral artery: six cases report]. No to shinkei = Brain and nerve 20050601
Transitioning from argatroban to warfarin in heparin-induced thrombocytopenia: an analysis of outcomes in patients with elevated international normalized ratio (INR). Journal of thrombosis and thrombolysis 20050601
The paradox of heparin-induced thrombocytopenia: the initial management. Orthopedics 20050601
Carotid tissue levels of argatroban after direct local delivery during carotid endarterectomy to prevent perioperative cerebral embolism. Neurosurgery 20050501
No increase in rejection or graft loss in kidney transplant recipients with thrombophilia treated with anticoagulation and triple immunosuppression. Transplantation proceedings 20050501
The use of argatroban for carotid endarterectomy in heparin-induced thrombocytopenia. Anesthesia and analgesia 20050401
Argatroban for anticoagulation during cardiopulmonary bypass in an infant. Paediatric anaesthesia 20050401
An anesthesia provider's perspective of heparin-induced thrombocytopenia. AANA journal 20050401
Heparin-induced thrombocytopenia: principles for early recognition and management. Cleveland Clinic journal of medicine 20050401
In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. Journal of medicinal chemistry 20050324
Antithrombotic potential of new direct thrombin inhibitors built on the azaphenylalanine scaffold in two rat venous thrombosis models. Thrombosis and haemostasis 20050301
Coagulation management of a patient with factor V Leiden mutation, lupus anticoagulant, and activated protein C resistance: a case report. Perfusion 20050301
Argatroban and renal replacement therapy in patients with heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20050201
Transition to an oral anticoagulant in patients with heparin-induced thrombocytopenia. Chest 20050201
Direct thrombin inhibitors in heparin-induced thrombocytopenia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050201
Use of the chromogenic factor X assay to predict the international normalized ratio in patients transitioning from argatroban to warfarin. Pharmacotherapy 20050201
Treatment of patients with a history of heparin-induced thrombocytopenia and anti-lepirudin antibodies with argatroban. Journal of thrombosis and thrombolysis 20050201
Spontaneous atrioventricular groove disruption during off-pump coronary artery bypass grafting. The Annals of thoracic surgery 20050101
Heparin-induced thrombocytopenia in the cardiovascular patient: diagnostic and treatment guidelines. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20050101
Thrombin, an ideal target for pharmacological inhibition: a review of direct thrombin inhibitors. American heart journal 20050101
Thrombin-directed inhibitors: pharmacology and clinical use. American heart journal 20050101
Systemic administration of argatroban reduces secondary brain damage in a rat model of intracerebral hemorrhage: histopathological assessment. Cerebrovascular diseases (Basel, Switzerland) 20050101
Argatroban treatment for patients with intolerance to heparin and hirudin. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20050101
Alternative parenteral anticoagulation with argatroban, a direct thrombin inhibitor. Expert review of cardiovascular therapy 20050101
Selective methodologies for the synthesis of biologically active piperidinic compounds. Chemical record (New York, N.Y.) 20050101
Heparin-induced thrombocytopenia. Disease-a-month : DM 20050101
Argatroban anticoagulation in patients with a history of heparin-induced thrombocytopenia. Thrombosis research 20050101
Clinical presentation and laboratory diagnosis of heparin-induced thrombocytopenia. Seminars in thoracic and cardiovascular surgery 20050101
Anticoagulant use in patients with chronic renal impairment. American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
Direct thrombin inhibitors are not equally effective in vivo against arterial thrombosis: in vivo evaluation of DuP714 and argatroban in a porcine angioplasty model and comparison to r-hirudin. Thrombosis research 20050101
New trends in anticoagulant treatments. Lupus 20050101
Thrombocytopenia following heparin flush. Progress in cardiovascular nursing 20050101
Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban. Pathophysiology of haemostasis and thrombosis 20050101
Direct thrombin inhibitors for treatment of heparin induced thrombocytopenia, deep vein thrombosis and atrial fibrillation. Current pharmaceutical design 20050101
Systemic use of argatroban reduces tumor mass, attenuates neurological deficits and prolongs survival time in rat glioma models. Acta neurochirurgica. Supplement 20050101
Severe argatroban-induced coagulopathy in a patient with a history of heparin-induced thrombocytopenia. The Annals of thoracic surgery 20041201
Argatroban as a heparin substitute in cases of heparin-induced thrombocytopenia. The Annals of thoracic surgery 20041201
A prospective comparison of three argatroban treatment regimens during hemodialysis in end-stage renal disease. Kidney international 20041201
Current role of antithrombotic agents in the treatment of acute coronary syndromes. Seminars in thrombosis and hemostasis 20041201
Compatibility of argatroban with selected cardiovascular agents. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20041115
[Clinical guidelines for stroke]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041110
Heparin-induced thrombocytopenia: diagnosis and management. Circulation 20041102
The effects of argatroban on thrombin generation and hemostatic activation in vitro. Anesthesia and analgesia 20041101
Effects of pentasaccharide (fondaparinux) and direct thrombin inhibitors on coagulation testing. Archives of pathology & laboratory medicine 20041001
Monitoring direct thrombin inhibitors: time for standardization. Anesthesiology 20041001
Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing. The Annals of pharmacotherapy 20040901
Pharmacokinetics and pharmacodynamics of argatroban in combination with a platelet glycoprotein IIB/IIIA receptor antagonist in patients undergoing percutaneous coronary intervention. Journal of clinical pharmacology 20040901
[Use of argatroban as a substitute for heparin in a patient with suspected HIT type II undergoing carotid endarterectomy]. Masui. The Japanese journal of anesthesiology 20040901
[Prospective randomized study of argatroban versus heparin anticoagulation therapy after percutaneous coronary intervention for acute myocardial infarction]. Journal of cardiology 20040801
Argatroban anticoagulation in conjunction with glycoprotein IIb/IIIa inhibition in patients undergoing percutaneous coronary intervention: an open-label, nonrandomized pilot study. Journal of thrombosis and thrombolysis 20040801
[Prevention and treatment of deep vein thrombosis with ximelagatran]. Deutsche medizinische Wochenschrift (1946) 20040723
Ability of anti-glycoprotein IIb/IIIa agents to dissolve platelet thrombi formed on a collagen surface under blood flow conditions. Journal of the American College of Cardiology 20040721
Argatroban anticoagulation in patients with acute ischemic stroke (ARGIS-1): a randomized, placebo-controlled safety study. Stroke 20040701
Intraoperative management of a congenital antithrombin deficient patient on chronic hemodialysis. Thrombosis and haemostasis 20040701
Local delivery of argatroban for the prevention of restenosis after coronary balloon angioplasty: a prospective randomized pilot study. Circulation journal : official journal of the Japanese Circulation Society 20040701
Heparin-induced thrombocytopenia and thrombosis in a patient with polycythemia vera. Internal medicine (Tokyo, Japan) 20040701
Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time. Thrombosis and haemostasis 20040601
Collagen-induced generation of platelet-derived microparticles in whole blood is dependent on ADP released from red blood cells and calcium ions. Platelets 20040601
[Heparin-induced thrombocytopenia in patients on hemodialysis]. Nihon rinsho. Japanese journal of clinical medicine 20040601
Direct thrombin inhibitors in the treatment of immune-mediated heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20040601
Percutaneous interventions in patients with immune-mediated heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20040601
Argatroban usage for anticoagulation for ECMO on a post-cardiac patient with heparin-induced thrombocytopenia. The journal of extra-corporeal technology 20040601
Heparinless cardiopulmonary bypass with argatroban in dogs. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040501
Argatroban therapy for antithrombin deficiency and mesenteric thrombosis: case report and review of the literature. Pharmacotherapy 20040501
[How to use anticoagulants in hemodialysis therapy]. Nihon rinsho. Japanese journal of clinical medicine 20040501
[Anticoagulant]. Nihon rinsho. Japanese journal of clinical medicine 20040501
Stroke in patients with heparin-induced thrombocytopenia and the effect of argatroban therapy. Critical care medicine 20040401
Effect of direct thrombin inhibitors, bivalirudin, lepirudin, and argatroban, on prothrombin time and INR values. American journal of clinical pathology 20040401
Synthetic selective inhibitors of coagulation factor Xa strongly inhibit thrombin generation without affecting initial thrombin forming time necessary for platelet activation in hemostasis. Journal of thrombosis and haemostasis : JTH 20040401
Acute ischemic stroke successfully treated using sequenced intravenous and intra-arterial thrombolysis and argatroban anticoagulation: a case study. Journal of thrombosis and thrombolysis 20040401
Developing an algorithm for treating heparin-induced thrombocytopenia. Clinical advances in hematology & oncology : H&O 20040401
Antithrombotic effects of FK419, a novel nonpeptide platelet GPIIb/IIIa antagonist, in a guinea pig photochemically induced middle cerebral artery thrombosis model: comparison with ozagrel and argatroban. The Journal of pharmacology and experimental therapeutics 20040301
Argatroban dosing in intensive care patients with acute renal failure and liver dysfunction. Pharmacotherapy 20040301
Small-molecule direct antithrombins: argatroban. Best practice & research. Clinical haematology 20040301
Treatment of heparin-induced thrombocytopenia: a critical review. Archives of internal medicine 20040223
Argatroban as anticoagulant in cardiopulmonary bypass in an infant and attempted reversal with recombinant activated factor VII. Anesthesiology 20040201
Failure of argatroban anticoagulation during off-pump coronary artery bypass surgery. The Annals of thoracic surgery 20040201
Argatroban use during pediatric interventional cardiac catheterization. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20040101
Influence of conduction disturbances on clinical outcome in patients with acute myocardial infarction receiving thrombolysis (results from the ARGAMI-2 study). The American journal of cardiology 20040101
Argatroban use in dialysis patients. Seminars in dialysis 20040101
Effect of renal function on the pharmacodynamics of argatroban. The Annals of pharmacotherapy 20040101
Direct thrombin inhibitors. Clinical laboratory science : journal of the American Society for Medical Technology 20040101
Argatroban as an alternative to heparin in extracorporeal membrane oxygenation circuits. Perfusion 20040101
Thrombin inhibitor, argatroban, prevents tumor cell migration and bone metastasis. Oncology 20040101
Alternatives to heparin infusion. Journal of infusion nursing : the official publication of the Infusion Nurses Society 20040101
Argatroban, a new treatment option for heparin-induced thrombocytopenia. Critical care nurse 20031201
Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome. Internal medicine (Tokyo, Japan) 20031201
Treatment options for heparin-induced thrombocytopenia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031015
Direct thrombin inhibitor therapy in the cardiovascular patient. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031015
Argatroban for off-pump coronary artery bypass surgery. Anesthesia and analgesia 20031001
Direct thrombin inhibitors for non-ST-segment elevation acute coronary syndromes: what, when, and where? American heart journal 20031001
Vascular surgery using argatroban in a patient with a history of heparin-induced thrombocytopenia. Circulation journal : official journal of the Japanese Circulation Society 20031001
Differential effects of DX-9065a, argatroban, and synthetic pentasaccharide on tissue thromboplastin inhibition test and dilute Russell's viper venom test. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20031001
Argatroban for heparin-induced thrombocytopenia in hepato-renal failure and CVVHD. The Annals of pharmacotherapy 20030901
Decreased argatroban clearance unaffected by hemodialysis in anasarca. The Annals of pharmacotherapy 20030901
Antithrombotic properties of a direct thrombin inhibitor with a prolonged half-life and AT-mediated factor Xa inhibitory activity. Journal of thrombosis and haemostasis : JTH 20030901
Argatroban inhibits staphylothrombin. Journal of thrombosis and haemostasis : JTH 20030901
Efficacious and orally bioavailable thrombin inhibitors based on a 2,5-thienylamidine at the P1 position: discovery of N-carboxymethyl-d-diphenylalanyl-l-prolyl[(5-amidino-2-thienyl)methyl]amide. Journal of medicinal chemistry 20030814
Argatroban attenuates leukocyte- and platelet-endothelial cell interactions after transient retinal ischemia. Stroke 20030801
Effects of argatroban as an anticoagulant for haemodialysis in patients with antithrombin III deficiency. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20030801
Argatroban anticoagulation in patients with heparin-induced thrombocytopenia. Archives of internal medicine 20030801
Pharmacologic platelet anesthesia by glycoprotein IIb/IIIa complex antagonist and argatroban during in vitro extracorporeal circulation. The Journal of thoracic and cardiovascular surgery 20030801
Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. European journal of pharmacology 20030725
Obstinate thrombosis during percutaneous coronary intervention in a case with heparin-induced thrombocytopenia with thrombosis syndrome successfully treated by argatroban anticoagulant therapy. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20030701
Direct thrombin inhibitors during PCI. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20030701
Heparin-induced thrombocytopenia--recognition and treatment. AORN journal 20030701
Ecarin chromogenic assay--a new method for quantitative determination of direct thrombin inhibitors like hirudin. Pathophysiology of haemostasis and thrombosis 20030701
The thrombin inhibitor argatroban does not influence the endothelium-dependent relaxant and contractile responses of isolated rabbit carotid arteries. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20030601
Excessive argatroban anticoagulation for heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20030501
Suppression of argatroban-induced endogenous thrombolysis by PKSI-527, and antibodies to TPA and UPA, evaluated in a rat arterial thrombolysis model. Thrombosis and haemostasis 20030501
Successful use of Argatroban as a heparin substitute during cardiopulmonary bypass: heparin-induced thrombocytopenia in a high-risk cardiac surgical patient. The Annals of thoracic surgery 20030501
Direct thrombin inhibitors. Expert opinion on pharmacotherapy 20030501
Predicting the pharmacology of thrombin inhibitors. Journal of thrombosis and haemostasis : JTH 20030501
Management of heparin-induced thrombocytopenia: a critical comparison of lepirudin and argatroban. Thrombosis research 20030501
Hemostatic analysis of a patient undergoing off-pump coronary artery bypass surgery with argatroban anticoagulation. Anesthesia and analgesia 20030401
Anticoagulation in acute cardiac care in patients with chronic kidney disease. American heart journal 20030401
Argatroban as an alternative anticoagulant for patients with heparin allergy during coronary bypass surgery. Heart and vessels 20030301
Argatroban, specific thrombin inhibitor, induced phenotype change of cultured rabbit vascular smooth muscle cells. European journal of pharmacology 20030207
Heparin-induced thrombocytopenia and cardiopulmonary bypass: perioperative argatroban use. The Annals of thoracic surgery 20030201
Characteristics of the hemostatic action of KFA-1411, an inhibitor of coagulation factor Xa (FXa), in humans and various animals. The Journal of toxicological sciences 20030201
Clinician update: direct thrombin inhibitors in acute coronary syndromes. Journal of thrombosis and thrombolysis 20030201
Acute pulmonary thromboembolism induced by prophylactic heparin use and a heparin-coated catheter: a case of heparin-induced thrombocytopenia and thrombosis syndrome. Circulation journal : official journal of the Japanese Circulation Society 20030101
Alternative methods of anticoagulation for dialysis-dependent patients with heparin-induced thrombocytopenia. Seminars in dialysis 20030101
Direct thrombin inhibitors in cardiac disease. Cardiovascular toxicology 20030101
Effects of argatroban and heparin on thrombus formation and tissue plasminogen activator-induced thrombolysis in a microvascular thrombosis model. Thrombosis research 20030101
Argatroban dosing in patients with heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20030101
Mild hypothermia enhances the neuroprotective effects of a selective thrombin inhibitor following transient focal ischemia in rats. Acta neurochirurgica. Supplement 20030101
Effect of delayed argatroban treatment on intracerebral hemorrhage-induced edema in the rat. Acta neurochirurgica. Supplement 20030101
A thrombin inhibitor reduces brain edema, glioma mass and neurological deficits in a rat glioma model. Acta neurochirurgica. Supplement 20030101
The effect of dietary bacillus natto productive protein on in vivo endogenous thrombolysis. Pathophysiology of haemostasis and thrombosis 20030101
Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. II. Effects on fibrinolysis. The Journal of biological chemistry 20021227
Studies on the different modes of action of the anticoagulant protease inhibitors DX-9065a and Argatroban. I. Effects on thrombin generation. The Journal of biological chemistry 20021227
Thrombosis increases circulatory hepatocyte growth factor by degranulation of mast cells. Circulation 20021210
Delayed argatroban treatment reduces edema in a rat model of intracerebral hemorrhage. Stroke 20021201
Argatroban in adult extracorporeal membrane oxygenation. The journal of extra-corporeal technology 20021201
Lack of pharmacokinetic interactions between argatroban and warfarin. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20021101
Low-molecular weight heparin: treatment failure in a patient with primary antiphospholipid antibody syndrome. The American journal of the medical sciences 20021101
Influence of lepirudin, argatroban, and melagatran on prothrombin time and additional effect of oral anticoagulation. Clinical chemistry 20021001
Argatroban anticoagulation during percutaneous coronary intervention in patients with heparin-induced thrombocytopenia. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20021001
Argatroban for percutaneous coronary interventions: hit or miss? Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20021001
Hirudin in heparin-induced thrombocytopenia. Seminars in thrombosis and hemostasis 20021001
Visual compatibility of argatroban with selected drugs. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020915
Current agents for the treatment of patients with heparin-induced thrombocytopenia. Current opinion in pulmonary medicine 20020901
Comment: treatment of heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20020901
Venous limb gangrene during overlapping therapy with warfarin and a direct thrombin inhibitor for immune heparin-induced thrombocytopenia. American journal of hematology 20020901
Preventing complications in heparin-induced thrombocytopenia. Alternative anticoagulants are improving patient outcomes. Postgraduate medicine 20020901
Antithrombotic drugs for the treatment of heparin-induced thrombocytopenia. Current opinion in investigational drugs (London, England : 2000) 20020801
[Experimental and clinical results with the thrombin inhibitor Argatroban]. Hamostaseologie 20020801
Monitoring of anticoagulant effects of direct thrombin inhibitors. Seminars in thrombosis and hemostasis 20020801
Investigation of the interaction between argatroban and acetaminophen, lidocaine, or digoxin. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020701
Monitoring of argatroban in ARG310 study: potential recommendations for its use in interventional cardiology. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20020701
Direct antithrombin agents ameliorate disseminated intravascular coagulation in suspected heparin-induced thrombocytopenia thrombosis syndrome. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20020701
The role of thrombin inhibition during percutaneous coronary intervention. Pharmacotherapy 20020601
[Heparin-induced thrombocytopenia: the clinical picture and treatment]. [Rinsho ketsueki] The Japanese journal of clinical hematology 20020601
Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy. Journal of thrombosis and thrombolysis 20020601
Combined argatroban and edaravone caused additive neuroprotection against 15 min of forebrain ischemia in gerbils. Neuroscience research 20020501
Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery. American journal of physiology. Heart and circulatory physiology 20020401
Direct thrombin inhibitors for percutaneous coronary intervention in the current era of platelet glycoprotein IIb/IIIa inhibition. Journal of interventional cardiology 20020401
Treatment of heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20020301
Argatroban therapy does not generate antibodies that alter its anticoagulant activity in patients with heparin-induced thrombocytopenia. Thrombosis research 20020301
Inhibitors of fibrinolytic components play different roles in the formation and removal of arterial thrombus in mice. Journal of cardiovascular pharmacology 20020201
Platelet shape changes and adhesion under high shear flow. Arteriosclerosis, thrombosis, and vascular biology 20020201
Substitution of Gly-548 to Ala in the substrate binding pocket of prothrombin Perijá leads to the loss of thrombin proteolytic activity. Thrombosis and haemostasis 20020201
An antibody that binds to primary specific pocket-associated structure in the active site of bovine thrombin. Hybridoma and hybridomics 20020201
Argatroban. Journal of thrombosis and thrombolysis 20020201
Direct thrombin inhibitors in acute coronary syndromes: principal results of a meta-analysis based on individual patients' data. Lancet (London, England) 20020126
Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. Bioorganic & medicinal chemistry letters 20020107
Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. Bioorganic & medicinal chemistry letters 20020107
[Intraoperative management for a patient with heparin-induced thrombocytopenia (HIT) undergoing off-pump coronary bypass surgery using argatroban, a direct thrombin inhibitor]. Masui. The Japanese journal of anesthesiology 20020101
Enhancement of endogenous plasminogen activator-induced thrombolysis by argatroban and APC and its control by TAFI, measured in an arterial thrombolysis model in vivo using rat mesenteric arterioles. Thrombosis and haemostasis 20020101
Therapeutic considerations in the management of patients with heparin-induced thrombocytopenia. Progress in cardiovascular nursing 20020101
Role of thrombin in CNS damage associated with intracerebral haemorrhage: opportunity for pharmacological intervention? CNS drugs 20020101
Effect of phenprocoumon on monitoring of lepirudin, argatroban, melagatran and unfractionated heparin with the PiCT method. Pathophysiology of haemostasis and thrombosis 20020101
An overview of the direct thrombin inhibitor argatroban. Pathophysiology of haemostasis and thrombosis 20020101
Development of argatroban as an anticoagulant and antithrombin agent in Japan. Pathophysiology of haemostasis and thrombosis 20020101
Argatroban in thrombotic stroke. Pathophysiology of haemostasis and thrombosis 20020101
Argatroban in HIT type II and acute coronary syndrome. Pathophysiology of haemostasis and thrombosis 20020101
Practical issues in the development of argatroban: a perspective. Pathophysiology of haemostasis and thrombosis 20020101
The use of argatroban as an anticoagulant for cardiopulmonary bypass in cardiac operations. The Journal of thoracic and cardiovascular surgery 20011201
Changes in blood viscosity by heparin and argatroban. Thrombosis research 20011201
The antithrombotic efficacy of AT-1459, a novel, direct thrombin inhibitor, in rat models of venous and arterial thrombosis. Thrombosis and haemostasis 20011201
Successful use of argatroban as an anticoagulant in burn-related severe acquired antithrombin III deficiency after heparin failure. Thrombosis and haemostasis 20011201
[Strategy for circulatory disturbance]. Rinsho shinkeigaku = Clinical neurology 20011201
Extension of the therapeutic window for recombinant tissue plasminogen activator with argatroban in a rat model of embolic stroke. Stroke 20011101
Anticoagulation with a selective thrombin inhibitor in a woman with heparin-induced thrombocytopenia. Obstetrics and gynecology 20011101
Argatroban. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011101
A synopsis of the clinical uses of argatroban. Journal of thrombosis and thrombolysis 20011001
Alternatives to unfractionated heparin for anticoagulation in cardiopulmonary bypass. Perfusion 20010901
A short synthesis of argatroban. a potent selective thrombin inhibitor. Bioorganic & medicinal chemistry letters 20010806
Thrombin promotes fibroblast proliferation during the early stages of experimental radiation pneumonitis. Radiation research 20010701
Broad-spectrum and selective serine protease inhibitors prevent expression of platelet-derived growth factor-BB and cerebral vasospasm after subarachnoid hemorrhage: vasospasm caused by cisternal injection of recombinant platelet-derived growth factor-BB. Stroke 20010701
Anticoagulation: the present and future. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20010701
Thrombin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia. Brain research 20010601
Direct thrombin inhibitors: are they the future of anticoagulation? South Dakota journal of medicine 20010601
Advances in the development of thrombin inhibitors. Expert opinion on investigational drugs 20010501
Argatroban anticoagulant therapy in patients with heparin-induced thrombocytopenia. Circulation 20010410
Argatroban for prevention and treatment of thromboembolism in heparin-induced thrombocytopenia. The Annals of pharmacotherapy 20010401
Heparin induced thrombocytopenia thrombosis (HIT/T) syndrome: diagnosis and treatment. Journal of clinical pathology 20010401
[Direct thrombin antagonists]. Herz 20010401
Off-pump coronary artery bypass for a heparin-allergic patient. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi 20010401
A specific thrombin inhibitor, argatroban, alleviates herpes zoster-associated pain. The Journal of dermatology 20010401
Postpartum coronary artery dissection complicated by heparin-induced thrombocytopenia and thrombosis. The Annals of thoracic surgery 20010301
Interpreting the International Normalized Ratio (INR) in individuals receiving argatroban and warfarin. Thrombosis and haemostasis 20010301
Argatroban for treatment of heparin-induced thrombocytopenia. The Medical letter on drugs and therapeutics 20010205
Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals. European journal of pharmacology 20010119
[Specific inhibition of thrombin activity during cardiopulmonary bypass reduces ischemia-reperfusion injury of the lung]. Fukuoka igaku zasshi = Hukuoka acta medica 20010101
Argatroban. Drugs 20010101
Enhanced thrombolysis induced by argatroban or activated protein C in the presence or absence of staphylokinase, measured in an in vivo animal model using mesenteric arterioles. Haemostasis 20010101
Argatroban: a direct thrombin inhibitor for heparin-induced thrombocytopenia and other clinical applications. Heart disease (Hagerstown, Md.) 20010101
Protease inhibitors: current status and future prospects. Journal of medicinal chemistry 20000210
In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. European journal of pharmacology 19991119
Pharmacological effects of a novel recombinant hirudin, CX-397, in vivo and in vitro: comparison with recombinant hirudin variant-1, heparin, and argatroban. Thrombosis and haemostasis 19990201
The first report of successful carotid stent implant using argatroban anticoagulation in a patient with heparin-induced thrombocytopenia and thrombosis syndrome: a case report. Angiology 19980101
Inhibition of collagen-induced platelet aggregation by argatroban in patients with acute cerebral infarction. Thrombosis research 19971015
Anticoagulation with Novastan (argatroban) in patients with heparin-induced thrombocytopenia and heparin-induced thrombocytopenia and thrombosis syndrome. Seminars in thrombosis and hemostasis 19970101
Properties