Chir-99021
| Title | Journal |
|---|---|
| Role of c-Abl-GSK3β Signaling in MPP+-Induced Autophagy-Lysosomal Dysfunction. | Toxicological sciences : an official journal of the Society of Toxicology 20180901 |
| Total particulate matter from cigarette smoke disrupts vascular development in zebrafish brain (Danio rerio). | Toxicology and applied pharmacology 20180115 |
| Cytoplasmic aryl hydrocarbon receptor regulates glycogen synthase kinase 3 beta, accelerates vimentin degradation, and suppresses epithelial-mesenchymal transition in non-small cell lung cancer cells. | Archives of toxicology 20170101 |
| Crosstalk between AhR and wnt/β-catenin signal pathways in the cardiac developmental toxicity of PM2.5 in zebrafish embryos. | Toxicology 20160429 |
| Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling. | Toxicological sciences : an official journal of the Society of Toxicology 20151101 |
| Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. | The Journal of biological chemistry 20150529 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Roles of glycogen synthase kinase 3 in Alzheimer's disease. | Current Alzheimer research 20120901 |
| Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway. | Stem cells and development 20120901 |
| Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress. | Molecular & cellular proteomics : MCP 20120801 |
| Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. | Nature biotechnology 20120701 |
| Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523 |
| Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. | Carcinogenesis 20120301 |
| Simple and efficient derivation of mouse embryonic stem cell lines using differentiation inhibitors or proliferation stimulators. | Stem cells and development 20120210 |
| Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics. | Bioorganic & medicinal chemistry 20120201 |
| Accelerated generation of human induced pluripotent stem cells with retroviral transduction and chemical inhibitors under physiological hypoxia. | Biochemical and biophysical research communications 20120113 |
| Establishment of ES cells from inbred strain mice by dual inhibition (2i). | The Journal of reproduction and development 20120101 |
| Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains. | PloS one 20120101 |
| New insights into the mechanisms of embryonic stem cell self-renewal under hypoxia: a multifactorial analysis approach. | PloS one 20120101 |
| Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells. | Angewandte Chemie (International ed. in English) 20111118 |
| Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy. | American journal of physiology. Cell physiology 20111101 |
| In vitro differentiation of rat embryonic stem cells into functional cardiomyocytes. | Cell research 20110901 |
| Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. | Cell death and differentiation 20110301 |
| Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100707 |
| Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. | Reproduction (Cambridge, England) 20100701 |
| Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability. | Genesis (New York, N.Y. : 2000) 20100501 |
| Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. | Stem cells (Dayton, Ohio) 20091201 |
| The ground state of embryonic stem cell self-renewal. | Nature 20080522 |
| 9-cyano-1-azapaullone (cazpaullone), a glycogen synthase kinase-3 (GSK-3) inhibitor activating pancreatic beta cell protection and replication. | Journal of medicinal chemistry 20080410 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| The Wnt signaling pathway as a target for the treatment of neurodegenerative disorders. | IDrugs : the investigational drugs journal 20060101 |
| Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element. | BMC molecular biology 20040101 |
| Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. | Diabetes 20030301 |
| Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. | Diabetes 20000201 |
| Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. | Diabetes 19990801 |
| Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. | Proceedings of the National Academy of Sciences of the United States of America 19930815 |