(17β)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
| Title | Journal |
|---|---|
| Novel role of mitochondrial manganese superoxide dismutase in STAT3 dependent pluripotency of mouse embryonic stem cells. | Scientific reports 20150101 |
| Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. | PloS one 20150101 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Study on TRPV1-mediated mechanism for the hypersecretion of mucus in respiratory inflammation. | Molecular immunology 20130101 |
| 2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells. | PloS one 20130101 |
| Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1α after traumatic brain injury (TBI). | Journal of the neurological sciences 20121215 |
| Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines. | Cellular & molecular biology letters 20121201 |
| Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia. | Prenatal diagnosis 20121101 |
| AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20121001 |
| 2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential. | Reproductive sciences (Thousand Oaks, Calif.) 20121001 |
| Modulation of the hypoxic response following partial bladder outlet obstruction. | The Journal of urology 20121001 |
| Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage. | Journal of molecular neuroscience : MN 20120901 |
| Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. | Biochimica et biophysica acta 20120801 |
| Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice. | Immunobiology 20120801 |
| 2-Methoxyestradiol induced Bax phosphorylation and apoptosis in human retinoblastoma cells via p38 MAPK activation. | Molecular carcinogenesis 20120701 |
| 2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells. | Fertility and sterility 20120701 |
| Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase. | The Biochemical journal 20120615 |
| Glycerol accumulation in edema formation following diffuse traumatic brain injury. | Neurological research 20120601 |
| Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase. | Molecular cancer research : MCR 20120601 |
| In vivo controlled release and prolonged antitumor effects of 2-methoxyestradiol solid lipid nanoparticles incorporated into a thermosensitive hydrogel. | Drug delivery 20120501 |
| Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma. | Biochemical and biophysical research communications 20120413 |
| A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate. | Investigational new drugs 20120401 |
| The increased expression of DEC1 gene is related to HIF-1α protein in gastric cancer cell lines. | Molecular biology reports 20120401 |
| Pharmacokinetic evaluation and antitumor activity of 2-methoxyestradiol nanosuspension. | Drug development and industrial pharmacy 20120401 |
| A simple and convenient synthesis of 2-methoxyestradiol from estrone. | Steroids 20120401 |
| Synthesis of 3'-methoxy-E-diethylstilbestrol and its analogs as tumor angiogenesis inhibitors. | Steroids 20120401 |
| Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells. | Gender medicine 20120401 |
| Preparation and cytotoxicity of poly (DL-lactide-co-glycolide) microspheres encapsulating 2-methoxyestradiol. | Drug delivery 20120401 |
| Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome. | Molecular and cellular endocrinology 20120305 |
| ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells. | Lung cancer (Amsterdam, Netherlands) 20120301 |
| Effects of 2-methoxyestradiol on proliferation, apoptosis and gene expression of cyclin B1 and c-Myc in esophageal carcinoma EC9706 cells. | Cell biochemistry and function 20120301 |
| 2-Hydroxyestradiol slows progression of experimental polycystic kidney disease. | American journal of physiology. Renal physiology 20120301 |
| Preparation and cytotoxicity of 2-methoxyestradiol-loaded solid lipid nanoparticles. | Anti-cancer drugs 20120201 |
| A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. | Electrophoresis 20120201 |
| Analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography-tandem mass spectrometry: a case study for breast cancer. | Analytica chimica acta 20120120 |
| Development of GC-MS/MS method with programmable temperature vaporization large volume injection for monitoring of 17β-estradiol and 2-methoxyestradiol in plasma. | Analytica chimica acta 20120104 |
| HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells. | Cellular and molecular life sciences : CMLS 20120101 |
| Serum 2-methoxyestradiol, an estrogen metabolite, is positively associated with serum HDL-C in a population-based sample. | Lipids 20120101 |
| Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide and Mucuna macrocarpa Stem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α. | Neurobiology of disease 20120101 |
| Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy. | Photochemistry and photobiology 20120101 |
| MAP Kinases and Prostate Cancer. | Journal of signal transduction 20120101 |
| Taxol alleviates 2-methoxyestradiol-induced endothelial permeability. | Vascular pharmacology 20120101 |
| Angiogenesis in head and neck cancer: a review of the literature. | Journal of oncology 20120101 |
| Preeclampsia, hypoxia, thrombosis, and inflammation. | Journal of pregnancy 20120101 |
| Preeclampsia: multiple approaches for a multifactorial disease. | Disease models & mechanisms 20120101 |
| RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response. | Cardiovascular diabetology 20120101 |
| Activation of CD40 with platelet derived CD154 promotes reactive oxygen species dependent death of human hepatocytes during hypoxia and reoxygenation. | PloS one 20120101 |
| ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma. | PloS one 20120101 |
| Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells. | International journal of nanomedicine 20120101 |
| 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process. | PloS one 20120101 |
| Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells. | BMC cancer 20120101 |
| Bevacizumab based chemotherapy in first line treatment of HER2 negative metastatic breast cancer: results of a Moroccan observational institutional study. | BMC research notes 20120101 |
| Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells. | PloS one 20120101 |
| Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C. | BMC cancer 20120101 |
| Molecular mechanisms of preeclampsia. | Journal of pregnancy 20120101 |
| Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity. | ASN neuro 20120101 |
| Development and validation of an automated high-throughput system for zebrafish in vivo screenings. | PloS one 20120101 |
| A comprehensive review of hypertension in pregnancy. | Journal of pregnancy 20120101 |
| Synthetic 2-methoxyestradiol derivatives: structure-activity relationships. | Current medicinal chemistry 20120101 |
| Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling. | PloS one 20120101 |
| Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells. | Cancer letters 20111227 |
| Hypoxia stimulates the production of the angiogenesis inhibitor 2-methoxyestradiol by swine granulosa cells. | Steroids 20111211 |
| A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC). | Investigational new drugs 20111201 |
| Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability. | American journal of respiratory cell and molecular biology 20111201 |
| Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation. | Endocrinology 20111201 |
| Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells. | Systems biology in reproductive medicine 20111201 |
| [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol]. | Zhongguo shi yan xue ye xue za zhi 20111201 |
| Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1. | Oncotarget 20111201 |
| Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles. | Die Pharmazie 20111201 |
| 2-Methoxyestradiol-bis-sulfamate induces apoptosis and autophagy in a tumorigenic breast epithelial cell line. | Molecular and cellular biochemistry 20111101 |
| Environmental impact on vascular development predicted by high-throughput screening. | Environmental health perspectives 20111101 |
| Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide. | Shock (Augusta, Ga.) 20111101 |
| Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment. | Oncotarget 20111001 |
| Pregnancy ameliorates the inhibitory effects of 2-methoxyestradiol on angiogenesis in primary sheep uterine endothelial cells. | Reproductive sciences (Thousand Oaks, Calif.) 20110901 |
| The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk. | The Journal of steroid biochemistry and molecular biology 20110901 |
| A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors. | Cancer chemotherapy and pharmacology 20110801 |
| Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II. | Archivum immunologiae et therapiae experimentalis 20110801 |
| Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells. | Carcinogenesis 20110801 |
| Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4. | Journal of medicinal chemistry 20110714 |
| Effect of 2-hydroxyestradiol on binge intake in rats. | Physiology & behavior 20110706 |
| Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells. | Cancer chemotherapy and pharmacology 20110701 |
| A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2). | Molecular human reproduction 20110701 |
| Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis. | Clinical immunology (Orlando, Fla.) 20110701 |
| Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis. | Allergy 20110701 |
| 2-methoxyestradiol attenuates autophagy activation after global ischemia. | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110701 |
| HIF-1-α and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats. | Neurological research 20110701 |
| Testosterone attenuates morpho-functional alterations by 2-methoxyestradiol exposure and induces differentiation in C6 cells. | Journal of cellular physiology 20110601 |
| 2ME and 2OHE2 exhibit growth inhibitory effects and cell cycle arrest at G2/M in RL95-2 human endometrial cancer cells through activation of p53 and Chk1. | Molecular and cellular biochemistry 20110601 |
| Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel. | Journal of drug targeting 20110501 |
| Selective inhibition of early--but not late--expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage. | Brain pathology (Zurich, Switzerland) 20110501 |
| Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD). | American journal of physiology. Renal physiology 20110501 |
| 2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant MCF-7/FIR breast cancer cells through multiple mechanisms. | International journal of radiation oncology, biology, physics 20110501 |
| 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo. | Molecular cancer therapeutics 20110501 |
| Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases. | American journal of respiratory and critical care medicine 20110415 |
| A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer. | Investigational new drugs 20110401 |
| Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy. | Biomaterials 20110401 |
| Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC. | Pain 20110401 |
| In vitro and in vivo evidence for anti-inflammatory properties of 2-methoxyestradiol. | The Journal of pharmacology and experimental therapeutics 20110301 |
| Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis. | The Journal of biological chemistry 20110218 |
| Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain. | Current neurovascular research 20110201 |
| 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. | Brain research 20110125 |
| The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury. | Journal of neurosurgery 20110101 |
| 2-Methoxyestradiol: new perspectives in colon carcinoma treatment. | Molecular and cellular endocrinology 20110101 |
| Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response. | Radiation oncology (London, England) 20110101 |
| Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia. | PloS one 20110101 |
| Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I. | BMC research notes 20110101 |
| Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation. | PloS one 20110101 |
| Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats. | Reproductive biology and endocrinology : RB&E 20110101 |
| Cancer therapeutic agents targeting hypoxia-inducible factor-1. | Current medicinal chemistry 20110101 |
| Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia. | International journal of molecular sciences 20110101 |
| The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus. | PloS one 20110101 |
| Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model. | Arthritis research & therapy 20110101 |
| P2Y receptors as regulators of lung endothelial barrier integrity. | Journal of cardiovascular disease research 20110101 |
| Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis. | PloS one 20110101 |
| Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene. | PloS one 20110101 |
| Effect of magnetic Fe3O4 nanoparticles with 2-methoxyestradiol on the cell-cycle progression and apoptosis of myelodysplastic syndrome cells. | International journal of nanomedicine 20110101 |
| Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy. | International journal of nanomedicine 20110101 |
| Mitochondrial peroxiredoxin III is a potential target for cancer therapy. | International journal of molecular sciences 20110101 |
| Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma. | Sarcoma 20110101 |
| The genetics of pulmonary arterial hypertension in the post-BMPR2 era. | Pulmonary circulation 20110101 |
| In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line. | Cancer cell international 20110101 |
| The effect of 2-methoxyestradiol liposome on growth inhibition, angiogenesis and expression of VEGF and Ki67 in mice bearing H22 hepatocellular carcinoma. | Tumori 20110101 |
| Functional and transcriptional induction of aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α. | PloS one 20110101 |
| Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females. | Respiratory research 20110101 |
| Lymph Node Staging with Choline PET/CT in Patients with Prostate Cancer: A Review. | ISRN oncology 20110101 |
| Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges. | Molecular pharmaceutics 20101206 |
| Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease. | Journal of cardiovascular pharmacology 20101201 |
| Influence of estradiol analogue on cell growth, morphology and death in esophageal carcinoma cells. | Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20101201 |
| Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. | Journal of medicinal chemistry 20101125 |
| Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling. | Journal of cardiovascular pharmacology 20101101 |
| Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection. | Hypertension (Dallas, Tex. : 1979) 20101101 |
| Additive growth inhibition after combined treatment of 2-methoxyestradiol and conventional chemotherapeutic agents in human pancreatic cancer cells. | Anticancer research 20101101 |
| Diaryl dimers of estradiol and of estrone may be formed as major metabolites by mouse mammary glands. | Biochemical and biophysical research communications 20101022 |
| 2-Methoxyestradiol--biology and mechanism of action. | Steroids 20101001 |
| Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. | The Journal of pharmacology and experimental therapeutics 20101001 |
| O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols. | Drug metabolism and disposition: the biological fate of chemicals 20101001 |
| HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium. | European journal of immunology 20101001 |
| Resveratrol, a red wine constituent, blocks the antimitogenic effects of estradiol on human female coronary artery smooth muscle cells. | The Journal of clinical endocrinology and metabolism 20100901 |
| Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats. | Toxicology and applied pharmacology 20100901 |
| HIF-2alpha--a mediator of osteoarthritis? | Cell research 20100901 |
| Pre-eclampsia: connecting angiogenic and metabolic pathways. | Trends in endocrinology and metabolism: TEM 20100901 |
| 2-Methoxyestradiol blocks cell-cycle progression at the G2/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells. | Acta biochimica et biophysica Sinica 20100901 |
| Acute effects of 2-methoxyestradiol on endothelial aortic No release in male and ovariectomized female rats. | Nitric oxide : biology and chemistry 20100801 |
| 2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle. | Experimental physiology 20100801 |
| In vitro effects of 2-methoxyestradiol-bis-sulphamate on cell growth, morphology and cell cycle dynamics in the MCF-7 breast adenocarcinoma cell line. | Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20100801 |
| Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia. | Journal of neuroscience research 20100701 |
| In vitro effects of 2-methoxyestradiol-bis-sulphamate on the non-tumorigenic MCF-12A cell line. | Cell biochemistry and function 20100701 |
| Preparation and characterization of freeze-dried 2-methoxyestradiol nanoparticle powders. | Die Pharmazie 20100701 |
| 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. | Hormones & cancer 20100601 |
| Phenylcinnamides as novel antimitotic agents. | Journal of medicinal chemistry 20100527 |
| In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. | Cancer research 20100515 |
| Correlation of 2-methoxyestradiol levels in cord blood and complications of prematurity. | Pediatric research 20100501 |
| ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties. | Molecular cancer therapeutics 20100501 |
| Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors. | Biochemistry 20100427 |
| N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines. | Journal of medicinal chemistry 20100422 |
| Simultaneous determination of eight estrogens and their metabolites in serum using liquid chromatography with electrochemical detection. | Talanta 20100415 |
| 2-Methoxyestradiol induce the conversion of human peripheral blood memory B lymphocytes into plasma cells. | Journal of immunological methods 20100415 |
| Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate. | Journal of medicinal chemistry 20100408 |
| 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells. | Journal of cellular biochemistry 20100401 |
| An SPME-GC-MS method using an octadecyl silica fibre for the determination of the potential angiogenesis modulators 17beta-estradiol and 2-methoxyestradiol in culture media. | Analytical and bioanalytical chemistry 20100401 |
| In vitro effects of 2-methoxyestradiol on morphology, cell cycle progression, cell death and gene expression changes in the tumorigenic MCF-7 breast epithelial cell line. | The Journal of steroid biochemistry and molecular biology 20100401 |
| 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways. | Biochemical pharmacology 20100315 |
| 2-methoxyestradiol inhibits atorvastatin-induced rounding of human vascular smooth muscle cells. | Journal of cellular physiology 20100301 |
| A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct. | Reproduction (Cambridge, England) 20100301 |
| 2-methoxyestradiol inhibits Barrett's esophageal adenocarcinoma growth and differentiation through differential regulation of the beta-catenin-E-cadherin axis. | Molecular cancer therapeutics 20100301 |
| 2-methoxyestradiol induces morpho-functional changes and impairs the microtubular system in mouse neuroblastoma and rat glioma cells. | Archives italiennes de biologie 20100301 |
| Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions. | The American journal of pathology 20100201 |
| Nongenomic inhibition of coronary constriction by 17ß-estradiol, 2-hydroxyestradiol, and 2-methoxyestradiol. | Canadian journal of physiology and pharmacology 20100201 |
| Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents. | British journal of cancer 20100119 |
| Preparation, characterization and in vivo evaluation of 2-methoxyestradiol-loaded liposomes. | International journal of pharmaceutics 20100115 |
| A human brainstem glioma xenograft model enabled for bioluminescence imaging. | Journal of neuro-oncology 20100101 |
| A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. | The Journal of steroid biochemistry and molecular biology 20100101 |
| An efficient, practical synthesis of 2-methoxyestradiol. | Steroids 20100101 |
| Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. | Autophagy 20100101 |
| New insights in synovial angiogenesis. | Joint, bone, spine : revue du rhumatisme 20100101 |
| Structure activity analysis of 2-methoxyestradiol analogues reveals targeting of microtubules as the major mechanism of antiproliferative and proapoptotic activity. | Molecular cancer therapeutics 20100101 |
| Effect of flaxseed consumption on urinary levels of estrogen metabolites in postmenopausal women. | Nutrition and cancer 20100101 |
| Triple-negative breast cancer: role of antiangiogenic agents. | Cancer journal (Sudbury, Mass.) 20100101 |
| Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells. | Respiratory research 20100101 |
| Novel approaches to treat experimental pulmonary arterial hypertension: a review. | Journal of biomedicine & biotechnology 20100101 |
| Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor. | BMC musculoskeletal disorders 20100101 |
| In vivo intratumor angiogenic treatment effects during taxane-based neoadjuvant chemotherapy of ovarian cancer. | BMC cancer 20100101 |
| Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity. | PloS one 20100101 |
| Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma. | Journal of oncology 20100101 |
| The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound. | PloS one 20100101 |
| Topical application of recombinant calreticulin peptide, vasostatin 48, alleviates laser-induced choroidal neovascularization in rats. | Molecular vision 20100101 |
| The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo. | BMC medicine 20100101 |
| Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer. | BMC cancer 20100101 |
| NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells. | Molecular cancer 20100101 |
| Comparison of estrogens and estrogen metabolites in human breast tissue and urine. | Reproductive biology and endocrinology : RB&E 20100101 |
| Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling. | Prilozi 20100101 |
| Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice. | PloS one 20100101 |
| Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells. | BMC cancer 20100101 |
| Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation. | Molecular cytogenetics 20100101 |
| 4-oxo-N-(4-hydroxyphenyl)retinamide: two independent ways to kill cancer cells. | PloS one 20100101 |
| Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway. | PloS one 20100101 |
| Polymorphisms in genes involved in the estrogen pathway and mammographic density. | BMC cancer 20100101 |
| Superoxide dismutase is upregulated in Staphylococcus aureus following protoporphyrin-mediated photodynamic inactivation and does not directly influence the response to photodynamic treatment. | BMC microbiology 20100101 |
| Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats. | Respiratory research 20100101 |
| Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial. | Breast cancer : basic and clinical research 20100101 |
| Intra-Laboratory Pre-Validation of a Human Cell Based in vitro Angiogenesis Assay for Testing Angiogenesis Modulators. | Frontiers in pharmacology 20100101 |
| p53 gene expression and 2-methoxyestradiol treatment differentially induce nuclear factor kappa B activation in human lung cancer cells with different p53 phenotypes. | DNA and cell biology 20091201 |
| The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression. | Cell cycle (Georgetown, Tex.) 20091201 |
| C2- and C4-position 17beta-estradiol metabolites and their relation to breast cancer. | Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20091201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20091201 |
| Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs. | Bioorganic & medicinal chemistry letters 20091115 |
| Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol. | Bioorganic & medicinal chemistry letters 20091101 |
| Angiogenesis in rheumatoid arthritis. | Autoimmunity 20091101 |
| An investigation on intestinal absorption of a new anticancer drug, 2-methoxyestradiol. | Die Pharmazie 20091101 |
| [2-methoxyestradiol disrupts aggresomes induction by bortezomib and potentiates apoptosis in multiple myeloma cells.]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20091101 |
| Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol. | Bioorganic & medicinal chemistry 20091015 |
| Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial. | Gynecologic oncology 20091001 |
| Potential vascular actions of 2-methoxyestradiol. | Trends in endocrinology and metabolism: TEM 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| [Regulation of 2-methoxyestradiol-induced cell apoptosis by mcl-1 and bax genes in myelodysplastic syndrome]. | Zhongguo shi yan xue ye xue za zhi 20091001 |
| Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma. | The Journal of biological chemistry 20090911 |
| 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities. | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20090901 |
| c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells. | Cancer research 20090901 |
| A short, economical synthesis of 2-methoxyestradiol, an anticancer agent in clinical trials. | The Journal of organic chemistry 20090821 |
| Superoxide is the major reactive oxygen species regulating autophagy. | Cell death and differentiation 20090701 |
| Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation. | Biochemical pharmacology 20090701 |
| Effects of estradiol metabolites on cAMP production and degradation. | Prilozi 20090701 |
| In vitro effects of 2-methoxyestradiol on cell numbers, morphology, cell cycle progression, and apoptosis induction in oesophageal carcinoma cells. | Cell biochemistry and function 20090601 |
| Therapeutic efficacy of 2-methoxyestradiol microcrystals encapsulated within polyelectrolyte multilayers. | Macromolecular bioscience 20090513 |
| Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1alpha expression. | Brain research 20090501 |
| Low dose combinations of 2-methoxyestradiol and docetaxel block prostate cancer cells in mitosis and increase apoptosis. | Cancer letters 20090408 |
| Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway. | European journal of pharmacology 20090401 |
| [Effects of 2-methoxyestradiol on the expression of caspase-3 and survivin in chronic myelocytic leukemia K562 cells]. | Zhongguo shi yan xue ye xue za zhi 20090401 |
| [Mechanism underlying 2-methoxyestradiol inducing apoptosis of K562 cells]. | Zhongguo shi yan xue ye xue za zhi 20090401 |
| Influence of 2-methoxyestradiol on MCF-7 cells: an improved differential interference contrasting technique and Bcl-2 and Bax protein expression levels. | Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20090401 |
| Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injury. | Neuroscience letters 20090327 |
| The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer. | British journal of cancer 20090324 |
| Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090301 |
| [Endocrine factors influencing melanoma progression]. | Magyar onkologia 20090301 |
| The specific effect of 2-methoxyestradiol on lymphatic vascular endothelial cells. | Die Pharmazie 20090301 |
| Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090215 |
| BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure. | British journal of cancer 20090210 |
| 2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells? | Breast cancer research and treatment 20090101 |
| Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells. | Molecular carcinogenesis 20090101 |
| Low catechol-O-methyltransferase and 2-methoxyestradiol in preeclampsia: more than a unifying hypothesis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090101 |
| Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. | The Journal of steroid biochemistry and molecular biology 20090101 |
| Mouse models for preeclampsia: disruption of redox-regulated signaling. | Reproductive biology and endocrinology : RB&E 20090101 |
| 2-methoxyestradiol as a potential cytostatic drug in gliomas? | Anti-cancer agents in medicinal chemistry 20090101 |
| A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents. | Angiogenesis 20090101 |
| Is there any potential link among caspase-8, p-p38 MAPK and bcl-2 in clear cell renal cell carcinomas? A comparative immunohistochemical analysis with clinical connotations. | Diagnostic pathology 20090101 |
| Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis. | Arthritis research & therapy 20090101 |
| 2-Methoxyestradiol mediated signaling network in pancreatic cancer. | Frontiers in bioscience (Landmark edition) 20090101 |
| Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis. | BMC musculoskeletal disorders 20090101 |
| MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel. | PloS one 20090101 |
| Cytotoxic effects of 2-methoxyestradiol in the hepatocellular carcinoma cell line HepG2. | Pharmacology 20090101 |
| 2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats. | Vascular pharmacology 20090101 |
| [Effect of low-dose 2-methoxyestradiol on the expressions of two isoforms of PRDM1 gene in myeloma]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090101 |
| Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice. | BMC cancer 20090101 |
| Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel. | PloS one 20090101 |
| Antiproliferative effects of 2-methoxyestradiol alone and in combination with chemotherapeutic agents on human endometrial cancer cells. | European journal of gynaecological oncology 20090101 |
| Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. | PloS one 20090101 |
| Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells. | PloS one 20090101 |
| Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. | Nutrition and cancer 20090101 |
| Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct. | Reproductive biology and endocrinology : RB&E 20090101 |
| Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. | PloS one 20090101 |
| Targeted delivery of albumin bound paclitaxel in the treatment of advanced breast cancer. | OncoTargets and therapy 20090101 |
| 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats. | Maturitas 20081220 |
| Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin. | Cancer research 20081215 |
| Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death. | International journal of oncology 20081201 |
| Bevacizumab in the treatment of HER2-negative breast cancer. | Biologics : targets & therapy 20081201 |
| The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer. | British journal of cancer 20081104 |
| Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. | Leukemia research 20081101 |
| Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol. | American journal of physiology. Heart and circulatory physiology 20081101 |
| An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor and basic fibroblast growth factor. | The Journal of rheumatology 20081101 |
| 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model. | Clinical immunology (Orlando, Fla.) 20081101 |
| 2-methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts. | Reproductive sciences (Thousand Oaks, Calif.) 20081101 |
| Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. | Journal of medicinal chemistry 20081009 |
| Hydrogels for potential colon drug release by thiol-ene conjugate addition of a new inulin derivative. | Macromolecular bioscience 20081008 |
| 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis. | Cancer chemotherapy and pharmacology 20081001 |
| 2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft. | Cancer chemotherapy and pharmacology 20081001 |
| Class I beta-tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions. | Molecular cancer therapeutics 20081001 |
| Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells. | Cancer letters 20080918 |
| Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma. | Fertility and sterility 20080901 |
| Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. | Cancer chemotherapy and pharmacology 20080901 |
| Effect of formulation parameters on 2-methoxyestradiol release from injectable cylindrical poly(DL-lactide-co-glycolide) implants. | European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080901 |
| HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. | Neurobiology of disease 20080901 |
| Ixabepilone: a new chemotherapeutic option for refractory metastatic breast cancer. | Biologics : targets & therapy 20080901 |
| 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest. | Journal of cellular biochemistry 20080801 |
| In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes. | Experimental parasitology 20080801 |
| Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography. | Nuclear medicine and biology 20080701 |
| Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. | Nature 20080619 |
| Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis. | Oncogene 20080612 |
| Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. | Endocrinology 20080601 |
| Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes. | Obesity (Silver Spring, Md.) 20080601 |
| Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198. | Molecular cancer therapeutics 20080601 |
| Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome. | Fertility and sterility 20080501 |
| An estrogen metabolite, 2-methoxyestradiol, disrupts cardiac microtubules and unmasks muscarinic inhibition of calcium current. | The Journal of pharmacology and experimental therapeutics 20080501 |
| Potentiation of 2-methoxyestradiol-induced cytotoxicity by blocking endothelin A receptor in prostate cancer cells. | The Prostate 20080501 |
| Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: an effect independent of an anti-angiogenic action. | International immunopharmacology 20080501 |
| Ovarian P450 aromatase activity in the catfish Heteropneustes fossilis: seasonal changes and effects of catecholestrogens. | General and comparative endocrinology 20080501 |
| Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin. | The Journal of steroid biochemistry and molecular biology 20080501 |
| Comparative effects of chemotherapeutic agents on the growth and survival of human adrenal carcinoma cells in culture. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080501 |
| The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats. | Neurological research 20080401 |
| Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells. | Cell biology international 20080401 |
| Phytoestrogens and breast cancer prevention: possible mechanisms of action. | Environmental health perspectives 20080401 |
| Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents. | Journal of medicinal chemistry 20080313 |
| Judah Folkman, a pioneer in the study of angiogenesis. | Angiogenesis 20080301 |
| Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. | PLoS medicine 20080301 |
| 2-Methoxyestradiol modulates beta-catenin in prostate cancer cells: a possible mediator of 2-methoxyestradiol-induced inhibition of cell growth. | International journal of cancer 20080201 |
| Is mitochondrial generation of reactive oxygen species a trigger for autophagy? | Autophagy 20080201 |
| Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. Part III. | Steroids 20080201 |
| Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs--Part II. | Steroids 20080201 |
| 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. | The American journal of pathology 20080201 |
| Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol-induced apoptosis in human acute myeloid leukemia. | Experimental hematology 20080201 |
| Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin. | Developmental dynamics : an official publication of the American Association of Anatomists 20080201 |
| New aspects of regulatory signaling pathways and novel therapies in pancreatic cancer. | Current molecular medicine 20080201 |
| STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080115 |
| Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells. | Cell death and differentiation 20080101 |
| Biodegradable and pH-sensitive hydrogels for potential colon-specific drug delivery: characterization and in vitro release studies. | Biomacromolecules 20080101 |
| The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo. | BMC developmental biology 20080101 |
| Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk. | BMC cancer 20080101 |
| 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling. | Vascular pharmacology 20080101 |
| Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines. | In vivo (Athens, Greece) 20080101 |
| A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer. | Anticancer research 20080101 |
| In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation. | Cell biochemistry and function 20080101 |
| Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice. | BMC cancer 20080101 |
| In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol. | Radiation oncology (London, England) 20080101 |
| Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine. | International journal of medical sciences 20080101 |
| ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. | BMC cancer 20080101 |
| New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death. | BMC cell biology 20080101 |
| Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. | Arthritis research & therapy 20080101 |
| Vascular involvement in rheumatic diseases: 'vascular rheumatology'. | Arthritis research & therapy 20080101 |
| Antitumor efficacy of combination of interferon-gamma-inducible protein 10 gene with gemcitabine, a study in murine model. | Journal of experimental & clinical cancer research : CR 20080101 |
| Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study. | BMC cancer 20080101 |
| Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. | BMC genomics 20080101 |
| HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury. | Acta neurochirurgica. Supplement 20080101 |
| Strategies for prostate cancer prevention: Review of the literature. | Indian journal of urology : IJU : journal of the Urological Society of India 20080101 |
| Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate. | Journal of medicinal chemistry 20071227 |
| The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. | British journal of cancer 20071217 |
| Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol. | Bioorganic & medicinal chemistry 20071215 |
| Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways. | Brain research 20071214 |
| 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. | International journal of cancer 20071201 |
| Catechol-o-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats. | Biology of reproduction 20071201 |
| 2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats. | Endocrine journal 20071201 |
| Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes. | Arthritis and rheumatism 20071201 |
| From the bench to the bedside: emerging new treatments in multiple myeloma. | Best practice & research. Clinical haematology 20071201 |
| SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule-disrupting agents. | Cancer biology & therapy 20071201 |
| Transcription factors Xbp-1, Blimp-1, and BSAP are involved in the regulation of plasmacytic differentiation induced by 2-methoxyestradiol in myeloma cell lines. | International journal of hematology 20071201 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20071201 |
| 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. | Cancer research 20071101 |
| Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines. | British journal of cancer 20071022 |
| Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20071015 |
| 3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity. | Journal of medicinal chemistry 20070906 |
| Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol. | Leukemia research 20070901 |
| The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice. | Endocrinology 20070901 |
| Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. | Journal of neurochemistry 20070901 |
| Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes. | Journal of gastroenterology and hepatology 20070901 |
| HPLC for stress-free screening of potential prostate cancer marker catechol estrogens in urine using a diamond-electrode electrochemical and a fluorescence detector. | Journal of separation science 20070901 |
| 2-Methoxyestradiol: a potential treatment for multiple proliferative disorders. | Endocrinology 20070901 |
| Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-Methoxyestradiol in prostate cancer models. | Cancer research 20070901 |
| Docetaxel monotherapy as second-line treatment for pretreated advanced non-small cell lung cancer patients. | The Korean journal of internal medicine 20070901 |
| 2-methoxyestradiol induces apoptosis and cell cycle arrest in human chondrosarcoma cells. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20070801 |
| Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis. | Nature clinical practice. Rheumatology 20070801 |
| 2-[methyl-(11)C]methoxyestradiol: synthesis, evaluation and pharmacokinetics for in vivo studies on angiogenesis. | Nuclear medicine and biology 20070801 |
| Porcine follicular fluids: comparison of solid-phase extraction and matrix solid-phase dispersion for the GC-MS determination of hormones during follicular growth. | Journal of pharmaceutical and biomedical analysis 20070727 |
| Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2-methoxyestradiol. | Journal of pharmaceutical sciences 20070701 |
| Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol. | Acta pharmacologica Sinica 20070701 |
| Antiangiogenesis in swine ovarian follicle: a potential role for 2-methoxyestradiol. | Steroids 20070701 |
| 2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents. | Drug discovery today 20070701 |
| Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice. | Canadian journal of physiology and pharmacology 20070701 |
| Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. | Cancer letters 20070608 |
| HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia. | Journal of molecular and cellular cardiology 20070601 |
| In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol. | British journal of cancer 20070507 |
| Effects of 2-methoxyestradiol on endometrial carcinoma xenografts. | Journal of cancer research and clinical oncology 20070501 |
| Integrated molecular profiling of SOD2 expression in multiple myeloma. | Blood 20070501 |
| 2-methoxyestradiol induces spindle aberrations, chromosome congression failure, and nondisjunction in mouse oocytes. | Biology of reproduction 20070501 |
| Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy. | Molecular cancer therapeutics 20070501 |
| [Regulation of c-myc expression by Blimp-1 during the differentiation of myeloma cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070501 |
| Mechanism of 2-methoxyestradiol-induced apoptosis in myelodysplastic syndrome MUTZ-1 cell line. | Zhongguo shi yan xue ye xue za zhi 20070401 |
| Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2. | American journal of physiology. Heart and circulatory physiology 20070301 |
| 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice. | Endocrinology 20070301 |
| Ovarian cancer risk and polymorphisms involved in estrogen catabolism. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070301 |
| [Alterations of telomerase activity and apoptosis induced by 2-methoxyestradiol in human myelodysplastic syndrome cell line MUTZ-1]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070301 |
| Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. | Investigational new drugs 20070201 |
| Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction. | American journal of physiology. Lung cellular and molecular physiology 20070201 |
| Urinary phytoestrogen excretion of rats bearing methylnitrosourea-induced mammary carcinoma in response to treatment with 2-methoxyestradiol. | The Journal of steroid biochemistry and molecular biology 20070201 |
| Influence of 2-methoxyestradiol on cell morphology and cdc2 kinase activity in WHCO3 esophageal carcinoma cells. | Biomedical research (Tokyo, Japan) 20070201 |
| 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells. | Cancer research 20070115 |
| Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070101 |
| Antiproliferative effect of polyphenols and sterols of virgin argan oil on human prostate cancer cell lines. | Cancer detection and prevention 20070101 |
| Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis. | Breast cancer research : BCR 20070101 |
| 2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats. | Journal of cardiovascular pharmacology 20070101 |
| Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer. | BMC cancer 20070101 |
| In vitro effects of 2-methoxyestradiol on cell morphology and Cdc2 kinase activity in SNO oesophageal carcinoma cells. | Cell biochemistry and function 20070101 |
| INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201. | Drugs in R&D 20070101 |
| Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein. | BMC cancer 20070101 |
| Comparison of 2-methoxyestradiol and methotrexate effects on non-Hodgkin's B-cell lymphoma. | Current eye research 20070101 |
| Estrogenic or antiestrogenic therapies for multiple myeloma? | Molecular cancer 20070101 |
| Breast tumour angiogenesis. | Breast cancer research : BCR 20070101 |
| The roles of beta-tubulin mutations and isotype expression in acquired drug resistance. | Cancer informatics 20070101 |
| Signaling mechanisms of endogenous angiogenesis inhibitors derived from type IV collagen. | Gene regulation and systems biology 20070101 |
| Bevacizumab: the evidence for its clinical potential in the treatment of nonsmall cell lung cancer. | Core evidence 20070101 |
| Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. | Cancer research 20061215 |
| 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension. | Vascular pharmacology 20061201 |
| 2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats. | Experimental neurology 20061201 |
| Estrogen metabolite 2-methoxyestradiol induces apoptosis and inhibits cell proliferation and collagen production in rat and human leiomyoma cells: a potential medicinal treatment for uterine fibroids. | Journal of the Society for Gynecologic Investigation 20061201 |
| 2-Methoxyestradiol inhibits superoxide anion generation while it enhances superoxide dismutase activity in swine granulosa cells. | Annals of the New York Academy of Sciences 20061201 |
| Antiangiogenic effect of oral 2-methoxyestradiol on choroidal neovascularization in mice. | Experimental eye research 20061101 |
| 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation. | Clinical cancer research : an official journal of the American Association for Cancer Research 20061101 |
| 2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts. | Journal of cellular biochemistry 20061001 |
| Tocopherols and saponins derived from Argania spinosa exert, an antiproliferative effect on human prostate cancer. | Cancer investigation 20061001 |
| Plasma protein binding of the investigational anticancer agent 2-methoxyestradiol. | Anti-cancer drugs 20060901 |
| Hypoxia-inducible factor-1 in human breast and prostate cancer. | Endocrine-related cancer 20060901 |
| Estrogens, enzyme variants, and breast cancer: a risk model. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060901 |
| 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. | Molecular cancer therapeutics 20060901 |
| 2-Methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle. | Circulation research 20060804 |
| Does 2-methoxyestradiol represent the new and improved hormone replacement therapy for atherosclerosis? | Circulation research 20060804 |
| Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. | The American journal of pathology 20060801 |
| HIF-1 and tumour radiosensitivity. | British journal of cancer 20060703 |
| SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms. | Bioorganic & medicinal chemistry letters 20060701 |
| Flavonoid-induced glutathione depletion: potential implications for cancer treatment. | Free radical biology & medicine 20060701 |
| A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells. | Journal of gastroenterology and hepatology 20060701 |
| Relative effects of estradiol-17beta (E2), catecholestrogens and clomiphene citrate on in vitro oocyte maturation in the catfish Heteropneustes fossilis (Bloch) and E2 inhibition of 2-hydroxyestradiol-induced maturation. | General and comparative endocrinology 20060601 |
| Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation. | Molecular pharmacology 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Effect of 2-methoxyestradiol, buthionine sulfoximine and hydrogen peroxide on the viability of renal carcinoma cell lines (ACHN and ACVB). | Biological & pharmaceutical bulletin 20060501 |
| Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family. | Cancer research 20060415 |
| [2-Methoxyestradiol -- a new compound for cancer treatment]. | Deutsche medizinische Wochenschrift (1946) 20060413 |
| Distinct tumor stage-specific inhibitory effects of 2-methoxyestradiol in a breast cancer mouse model associated with Id-1 expression. | Cancer research 20060401 |
| Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060401 |
| [Effect of 2-methoxyestradiol on differentiation of primary myeloma cells]. | Zhongguo shi yan xue ye xue za zhi 20060401 |
| Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways. | Biochemistry 20060321 |
| Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species. | Journal of cell science 20060315 |
| Analysis of fifteen estrogen metabolites using packed column supercritical fluid chromatography-mass spectrometry. | Analytical chemistry 20060301 |
| p38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2. | Apoptosis : an international journal on programmed cell death 20060301 |
| Different effects of estradiol and various antiestrogens on TNF-alpha-induced changes of biochemical markers for growth and invasion of human breast cancer cells. | Life sciences 20060223 |
| 2-methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells. | Hypertension (Dallas, Tex. : 1979) 20060201 |
| 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060201 |
| 14-3-3sigma, a p53 regulator, suppresses tumor growth of nasopharyngeal carcinoma. | Molecular cancer therapeutics 20060201 |
| Preliminary investigation of 2-methoxyestradiol inducing differentiation of myeloma cell line CZ-1. | Zhongguo shi yan xue ye xue za zhi 20060201 |
| 2-methoxyestradiol induces apoptosis in cultured human anaplastic thyroid carcinoma cells. | Thyroid : official journal of the American Thyroid Association 20060201 |
| 2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction of apoptosis in prostate cancer cells. | Cancer letters 20060108 |
| Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors. | Cancer biology & therapy 20060101 |
| The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells. | Cancer research 20060101 |
| Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A. | Breast cancer research : BCR 20060101 |
| Encapsulation of submicrometer-sized 2-methoxyestradiol crystals into polymer multilayer capsules for biological applications. | Molecular pharmaceutics 20060101 |
| Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol. | Molecular pharmaceutics 20060101 |
| The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria. | Hereditary cancer in clinical practice 20060101 |
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| Anti-angiogenic therapy and chemotherapy affect 99mTc sestamibi and 99mTc-HL91 accumulation differently in tumour xenografts. | Nuclear medicine communications 20051201 |
| Effective transscleral delivery of two retinal anti-angiogenic molecules: carboxyamido-triazole (CAI) and 2-methoxyestradiol (2ME2). | Retina (Philadelphia, Pa.) 20051201 |
| Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates. | International journal of cancer 20051020 |
| beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells. | Cancer research 20051015 |
| Estrogen effects on tubulin expression and taxane mediated cytotoxicity in prostate cancer cells. | The Prostate 20051001 |
| Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats. | Journal of cardiovascular pharmacology 20051001 |
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| A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. | Journal of medicinal chemistry 20050922 |
| Resistance to paclitaxel is proportional to cellular total antioxidant capacity. | Cancer research 20050915 |
| A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050915 |
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| Effects of hormone deprivation and 2-methoxyestradiol combination therapy on hormone-dependent prostate cancer in vivo. | Neoplasia (New York, N.Y.) 20050901 |
| The potential and suitability of 2-methoxyestradiol in cancer therapy. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050815 |
| A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents. | Journal of medicinal chemistry 20050811 |
| Perspectives for combination therapy to overcome drug-resistant multiple myeloma. | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20050801 |
| Trigeminal pain transmission requires reactive oxygen species production. | Brain research 20050719 |
| Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents. | Biochemical pharmacology 20050701 |
| Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition. | Journal of cardiovascular pharmacology 20050701 |
| Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause. | Cancer research 20050701 |
| ZD6474--clinical experience to date. | British journal of cancer 20050601 |
| Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells. | Biomedical research (Tokyo, Japan) 20050601 |
| 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. | Oncogene 20050526 |
| Colchicine and 2-methoxyestradiol Inhibit Human Angiogenesis. | The Journal of surgical research 20050501 |
| 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. | The Journal of biological chemistry 20050415 |
| Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism. | American journal of physiology. Cell physiology 20050401 |
| NADPH-dependent metabolism of 17beta-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms. | Steroids 20050401 |
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| Targeted therapy in multiple myeloma. | Cancer control : journal of the Moffitt Cancer Center 20050401 |
| Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells. | Biomedical research (Tokyo, Japan) 20050401 |
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| [Investigation of the effect of 2-methoxyestradiol and arsenic trioxide on the apoptosis-associated gene expression profile of myeloma cells]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050401 |
| Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity. | Oncogene 20050310 |
| 2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20050301 |
| Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton. | Journal of neuro-oncology 20050301 |
| Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. | Journal of molecular endocrinology 20050201 |
| Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer. | Cancer research 20050115 |
| Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast. | The Journal of clinical endocrinology and metabolism 20050101 |
| Determination of 2-methoxyestradiol in human plasma, using liquid chromatography/tandem mass spectrometry. | Rapid communications in mass spectrometry : RCM 20050101 |
| Antiproliferative activity and toxicity of 2-methoxyestradiol in cervical cancer xenograft mice. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101 |
| Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulation. | Clinical neuropathology 20050101 |
| Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study. | Breast cancer research : BCR 20050101 |
| Possible protective effects of alpha-tocopherol on enhanced induction of reactive oxygen species by 2-methoxyestradiol in tumors. | Advances in experimental medicine and biology 20050101 |
| Effects of dioxin on metabolism of estrogens in waste incinerator workers. | Archives of environmental & occupational health 20050101 |
| 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20041215 |
| In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma. | International journal of cancer 20041210 |
| 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells. | Acta pharmacologica Sinica 20041101 |
| Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. | Free radical biology & medicine 20041015 |
| Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization. | Journal of medicinal chemistry 20041007 |
| Effects of 2-methoxyestradiol on proliferation, apoptosis and PET-tracer uptake in human prostate cancer cell aggregates. | Nuclear medicine and biology 20041001 |
| The new cancer blockers. | The Johns Hopkins medical letter health after 50 20041001 |
| Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol. | Biochemical and biophysical research communications 20040924 |
| Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth. | Oncogene 20040916 |
| 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro. | Cancer letters 20040915 |
| Mass spectrometric measurement of differential reactivity of cysteine to localize protein-ligand binding sites. Application to tubulin-binding drugs. | Analytical biochemistry 20040915 |
| In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol. | Chemical research in toxicology 20040901 |
| Examination of a modified cell cycle synchronization method and bovine nuclear transfer using synchronized early G1 phase fibroblast cells. | Theriogenology 20040801 |
| Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. | The Journal of clinical endocrinology and metabolism 20040801 |
| 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity. | Acta medica Okayama 20040801 |
| Effects of estrogens and metabolites on endometrial carcinogenesis in young adult mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine. | Cancer letters 20040728 |
| Chemotherapy of breast cancer-additive anticancerogenic effects by 2-methoxyestradiol? | Life sciences 20040723 |
| Determination of the antiangiogenesis agent 2-methoxyestradiol in human plasma by liquid chromatography with ultraviolet detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705 |
| Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation. | The Journal of biological chemistry 20040702 |
| Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy. | European journal of nuclear medicine and molecular imaging 20040701 |
| New drugs for treatment of multiple myeloma. | The Lancet. Oncology 20040701 |
| 2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents. | Bioorganic & medicinal chemistry letters 20040621 |
| 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. | The Journal of pharmacology and experimental therapeutics 20040601 |
| Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model. | World journal of gastroenterology 20040501 |
| Differential regulation of estrogen receptor subtypes alpha and beta in human aortic smooth muscle cells by oligonucleotides and estradiol. | The Journal of clinical endocrinology and metabolism 20040501 |
| Mitochondrial superoxide dismutase: a promising target for new anticancer therapies. | Current medicinal chemistry 20040501 |
| 2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases. | Apoptosis : an international journal on programmed cell death 20040501 |
| Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341. | Oncogene 20040429 |
| Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates. | International journal of cancer 20040420 |
| Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft. | British journal of cancer 20040405 |
| A gas chromatography/mass spectrometry assay to measure estradiol, catecholestradiols, and methoxyestradiols in plasma. | Steroids 20040401 |
| Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. | Cancer chemotherapy and pharmacology 20040301 |
| 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27. | Apoptosis : an international journal on programmed cell death 20040301 |
| Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells. | The Journal of steroid biochemistry and molecular biology 20040301 |
| Pulsed estrogen exposure selectively modulates tissue response: a hypothesis. | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040301 |
| Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. | British journal of cancer 20040223 |
| Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates. | Journal of cellular biochemistry 20040215 |
| A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells. | Toxicology and applied pharmacology 20040215 |
| 2-methoxyestradiol induces caspase-independent, mitochondria-centered apoptosis in DS-sarcoma cells. | International journal of cancer 20040210 |
| A simple quantitative method for evaluation of angiogenesis activity. | Assay and drug development technologies 20040201 |
| Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments. | Breast cancer research : BCR 20040101 |
| The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. | Molecular carcinogenesis 20040101 |
| The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins. | BMC neuroscience 20040101 |
| Cytotoxic effects of B lymphocytes mediated by reactive oxygen species. | Current pharmaceutical design 20040101 |
| Recent translational research: antiangiogenic therapy for breast cancer - where do we stand? | Breast cancer research : BCR 20040101 |
| [Report of the National Oncology Research and Developement Consortium, 2003]. | Magyar onkologia 20040101 |
| Induction of apoptosis and G2/M arrest by 2-methoxyestradiol in human cervical cancer HeLaS3 cells. | Anticancer research 20040101 |
| Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study. | Breast cancer research : BCR 20040101 |
| Is the combination with 2-methoxyestradiol able to reduce the dosages of chemotherapeutices in the treatment of human ovarian cancer? Preliminary in vitro investigations. | European journal of gynaecological oncology 20040101 |
| Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment. | Angiogenesis 20040101 |
| Induction of apoptosis or necrosis in human endometrial carcinoma cells by 2-methoxyestradiol. | Anticancer research 20040101 |
| Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice. | Circulation 20031216 |
| Exposure of bovine oocytes to the endogenous metabolite 2-methoxyestradiol during in vitro maturation inhibits early embryonic development. | Biology of reproduction 20031201 |
| Pharmacogenetics of estrogen metabolism and transport in relation to cancer. | Current drug metabolism 20031201 |
| Mechanism of action of 2-methoxyestradiol: new developments. | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20031201 |
| TNFalpha potentiates 2-methoxyestradiol-induced mitochondrial death pathway. | Annals of the New York Academy of Sciences 20031201 |
| Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery. | Biochemical pharmacology 20031115 |
| Neuroprotective and neurotoxic effects of estrogens. | Brain research 20031114 |
| The nonsteroidal effects of diethylstilbestrol: the rationale for androgen deprivation therapy without estrogen deprivation in the treatment of prostate cancer. | The Journal of urology 20031101 |
| 2-methoxyestradiol strongly inhibits human uterine sarcomatous cell growth. | Gynecologic oncology 20031101 |
| New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. | Current opinion in oncology 20031101 |
| [Estrogen-dependent neoplasia - what is the significance of estradiol metabolites]. | Zentralblatt fur Gynakologie 20031101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20031101 |
| Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. | The Journal of biological chemistry 20030926 |
| Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells. | Oncogene 20030918 |
| Catecholamines block the antimitogenic effect of estradiol on human glomerular mesangial cells. | Hypertension (Dallas, Tex. : 1979) 20030901 |
| 2-Methoxyestradiol exhibits a biphasic effect on VEGF-A in tumor cells and upregulation is mediated through ER-alpha: a possible signaling pathway associated with the impact of 2-ME2 on proliferative cells. | Neoplasia (New York, N.Y.) 20030901 |
| In vitro effects of 2-methoxyestradiol on canine tumour cells. | Veterinary and comparative oncology 20030901 |
| Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications. | Apoptosis : an international journal on programmed cell death 20030801 |
| Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. | Toxicology and applied pharmacology 20030801 |
| The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis. | The Journal of steroid biochemistry and molecular biology 20030801 |
| Comparison of ex vivo inhibitory effect between 2-hydroxyestradiol and its 17-sulfate on rat hepatic microsomal lipid peroxidation. | Lipids 20030801 |
| Carboxymethyl benzylamide dextran inhibits angiogenesis and growth of VEGF-overexpressing human epidermoid carcinoma xenograft in nude mice. | British journal of cancer 20030707 |
| 2-methoxyestradiol alters cell motility, migration, and adhesion. | Blood 20030701 |
| Methylation of 2-hydroxyestradiol in isolated organs. | Hypertension (Dallas, Tex. : 1979) 20030701 |
| Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11. | British journal of cancer 20030616 |
| Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1. | Cancer research 20030615 |
| Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. | Carcinogenesis 20030601 |
| Structure/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity. | The Journal of steroid biochemistry and molecular biology 20030601 |
| Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents. | Blood 20030515 |
| Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays. | Blood 20030501 |
| 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production. | Oncogene 20030501 |
| Synthesis and evaluation of a novel nonsteroidal-specific endothelial cell proliferation inhibitor. | Journal of medicinal chemistry 20030410 |
| Novel 2-methoxyestradiol analogues with antitumor activity. | Cancer research 20030401 |
| Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications? | Melanoma research 20030401 |
| 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. | Cancer cell 20030401 |
| Novel therapies in multiple myeloma. | International journal of hematology 20030401 |
| Short synthesis of 2-methoxyestradiol and 2-hydroxyestradiol. | Steroids 20030401 |
| Metabolism of [6,7-3H, 35S] estradiol 17-sulfate in rats. | Steroids 20030401 |
| IDN 5390: an oral taxane candidate for protracted treatment schedules. | British journal of cancer 20030324 |
| Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis. | FEBS letters 20030313 |
| Medical hypothesis: hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer. | International journal of oncology 20030301 |
| Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat. | Endocrinology 20030301 |
| In vitro effects of catecholamines and catecholestrogens on brain tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis. | Journal of neuroendocrinology 20030301 |
| Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma. | Pancreas 20030301 |
| CYP450- and COMT-derived estradiol metabolites inhibit activity of human coronary artery SMCs. | Hypertension (Dallas, Tex. : 1979) 20030301 |
| 2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: implications for management. | Carcinogenesis 20030201 |
| 2-Methoxyestradiol, a promising anticancer agent. | Pharmacotherapy 20030201 |
| Effect of tamoxifen and 2-methoxyestradiol alone and in combination on human breast cancer cell proliferation. | The Journal of steroid biochemistry and molecular biology 20030201 |
| Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate. | The Journal of steroid biochemistry and molecular biology 20030201 |
| The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells. | The Journal of steroid biochemistry and molecular biology 20030201 |
| Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. | The Journal of steroid biochemistry and molecular biology 20030201 |
| 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. | Cancer research 20030115 |
| The effect of endogenous estradiol metabolites on the proliferation of human breast cancer cells. | Life sciences 20030110 |
| Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor. | The Journal of biological chemistry 20030103 |
| Novel therapies for multiple myeloma. | British journal of haematology 20030101 |
| Effect of 2-methoxyestradiol on the growth of methyl-nitroso-urea (MNU)-induced rat mammary carcinoma. | The Journal of steroid biochemistry and molecular biology 20030101 |
| INGN 201: Ad-p53, Ad5CMV-p53, Adenoviral p53, INGN 101, p53 gene therapy--Introgen, RPR/INGN 201. | BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101 |
| Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus. | Reproductive biology and endocrinology : RB&E 20030101 |
| 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells. | Cancer letters 20021210 |
| A new, practical synthesis of 2-methoxyestradiols. | Steroids 20021201 |
| Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. | Steroids 20021201 |
| Promising preclinical activity of 2-methoxyestradiol in multiple myeloma. | Clinical cancer research : an official journal of the American Association for Cancer Research 20021201 |
| Introgen obtains key patent obtained for p53-targeted chemotherapy. | Expert review of anticancer therapy 20021201 |
| Regulation of the activation of nuclear factor kappaB by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways. | Antioxidants & redox signaling 20021201 |
| Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol. | The Journal of biological chemistry 20021122 |
| Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. | FEBS letters 20021106 |
| Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation. | The Journal of endocrinology 20021101 |
| The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization. | Journal of medicinal chemistry 20021010 |
| Estradiol metabolism and malignant disease. | Maturitas 20020930 |
| 2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment. | European journal of medical research 20020930 |
| 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells. | Blood 20020915 |
| Novel therapies for multiple myeloma. | Blood reviews 20020901 |
| Evidence that 2-methoxyestradiol suppresses proliferation and accelerates apoptosis in normal rat growth plate chondrocytes. | Journal of cancer research and clinical oncology 20020901 |
| 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. | Cancer research 20020701 |
| Tumour microvessel density as predictor of chemotherapy response in breast cancer patients. | British journal of cancer 20020617 |
| 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells. | Oncogene 20020613 |
| Introduction of a novel proliferation assay for pharmacological studies allowing the combination of BrdU detection and phenotyping. | Journal of immunological methods 20020601 |
| 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding. | Molecular pharmacology 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| A radical approach to cancer. | Medical science monitor : international medical journal of experimental and clinical research 20020401 |
| Catecholamines block 2-hydroxyestradiol-induced antimitogenesis in mesangial cells. | Hypertension (Dallas, Tex. : 1979) 20020401 |
| Methoxyestradiols mediate estradiol-induced antimitogenesis in human aortic SMCs. | Hypertension (Dallas, Tex. : 1979) 20020401 |
| Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells. | Drug and chemical toxicology 20020201 |
| 2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells. | Bone 20020201 |
| Role of methoxyestradiols in the growth inhibitory effects of estradiol on human glomerular mesangial cells. | Hypertension (Dallas, Tex. : 1979) 20020201 |
| Safety and pharmacokinetics of intravitreal 2-methoxyestradiol implants in normal rabbit and pharmacodynamics in a rat model of choroidal neovascularization. | Experimental eye research 20020201 |
| Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells. | Acta biochimica Polonica 20020101 |
| Reduction of post injury neointima formation due to 17beta-estradiol and phytoestrogen treatment is not influenced by the pure synthetic estrogen receptor antagonist ICI 182,780 in vitro. | BMC cardiovascular disorders 20020101 |
| Mitochondrial defects in cancer. | Molecular cancer 20020101 |
| Identification of small molecule binding sites within proteins using phage display technology. | Combinatorial chemistry & high throughput screening 20011101 |
| Catecholamines abrogate antimitogenic effects of 2-hydroxyestradiol on human aortic vascular smooth muscle cells. | Arteriosclerosis, thrombosis, and vascular biology 20011101 |
| Estradiol, in the CNS, targets several physiologically relevant membrane-associated proteins. | Brain research. Brain research reviews 20011101 |
| Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms. | Cancer research 20010915 |
| Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts. | European journal of nuclear medicine 20010901 |
| 2-methoxyestradiol does not inhibit superoxide dismutase. | Archives of biochemistry and biophysics 20010815 |
| 2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer. | Biochemical and biophysical research communications 20010803 |
| 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator. | Biology of reproduction 20010801 |
| 2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells. | Cancer 20010801 |
| Inhibition of large-conductance calcium-activated potassium channel by 2-methoxyestradiol in cultured vascular endothelial (HUV-EC-C) cells. | The Journal of membrane biology 20010801 |
| Structure-effect relationship in the induction of mitotic phase-specific abnormality of centrosome integrity and multipolar spindles by steroidal estrogens and their derivatives in cultured mammalian cells. | The Journal of steroid biochemistry and molecular biology 20010801 |
| 2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics. | The Journal of steroid biochemistry and molecular biology 20010801 |
| The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors. | Journal of cancer research and clinical oncology 20010701 |
| 2-methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells. | Molecular carcinogenesis 20010701 |
| Aromatase regulation and breast cancer. | Clinical endocrinology 20010501 |
| The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors. | Cancer research 20010415 |
| Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism. | Hypertension (Dallas, Tex. : 1979) 20010201 |
| Effects of estradiol and its metabolites on glomerular endothelial nitric oxide synthesis and mesangial cell growth. | Hypertension (Dallas, Tex. : 1979) 20010201 |
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