JNJ-7777120
| Title | Journal |
|---|---|
| Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo. | Journal of dermatological science 20160801 |
| Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity. | Gut 20141201 |
| Discovery and SAR of 6-alkyl-2,4-diaminopyrimidines as histamine H₄ receptor antagonists. | Journal of medicinal chemistry 20140327 |
| Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability. | British journal of pharmacology 20121001 |
| Advantages of histamine H4 receptor antagonist usage with H1 receptor antagonist for the treatment of murine allergic contact dermatitis. | Experimental dermatology 20120901 |
| The antagonism of histamine H1 and H4 receptors ameliorates chronic allergic dermatitis via anti-pruritic and anti-inflammatory effects in NC/Nga mice. | Allergy 20120801 |
| Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands. | European journal of medicinal chemistry 20120801 |
| Incomplete activation of human eosinophils via the histamine H4-receptor: evidence for ligand-specific receptor conformations. | Biochemical pharmacology 20120715 |
| A bioinformatics search for selective histamine h4 receptor antagonists through structure-based virtual screening strategies. | Chemical biology & drug design 20120501 |
| Role of histamine and its receptor subtypes in stimulation of conjunctival goblet cell secretion. | Investigative ophthalmology & visual science 20120501 |
| Synthesis of novel histamine H4 receptor antagonists. | Bioorganic & medicinal chemistry letters 20120115 |
| Strain-dependent effects of the histamine H₄ receptor antagonist JNJ7777120 in a murine model of acute skin inflammation. | Experimental dermatology 20120101 |
| Ligand based design of novel histamine H₄ receptor antagonists; fragment optimization and analysis of binding kinetics. | Bioorganic & medicinal chemistry letters 20120101 |
| Opposite effects of mepyramine on JNJ 7777120-induced amelioration of experimentally induced asthma in mice in sensitization and provocation. | PloS one 20120101 |
| Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression. | PloS one 20120101 |
| Effects of histamine H4 receptor ligands in a mouse model of gastric ulceration. | Pharmacology 20120101 |
| Molecular determinants of ligand binding modes in the histamine H(4) receptor: linking ligand-based three-dimensional quantitative structure-activity relationship (3D-QSAR) models to in silico guided receptor mutagenesis studies. | Journal of medicinal chemistry 20111208 |
| Challenges of drug discovery in novel target space. The discovery and evaluation of PF-3893787: a novel histamine H4 receptor antagonist. | Bioorganic & medicinal chemistry letters 20111101 |
| Mepyramine-JNJ7777120-hybrid compounds show high affinity to hH(1)R, but low affinity to hH(4)R. | Bioorganic & medicinal chemistry letters 20111101 |
| Discovery of a series of potent and selective human H4 antagonists using ligand efficiency and libraries to explore structure-activity relationship (SAR). | Bioorganic & medicinal chemistry letters 20111101 |
| Role of H4 receptor in histamine-mediated responses in human melanoma. | Melanoma research 20111001 |
| Histamine H(4) receptor antagonist reduces dermal inflammation and pruritus in a hapten-induced experimental model. | European journal of pharmacology 20110930 |
| Histamine H1, H3 and H4 receptors are involved in pruritus. | Neuroscience 20110908 |
| Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation. | Naunyn-Schmiedeberg's archives of pharmacology 20110901 |
| Lack of preventing effect of systemically and topically administered histamine H(1) or H(4) receptor antagonists in a dog model of acute atopic dermatitis. | Experimental dermatology 20110701 |
| Histamine H₄ receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation. | European journal of immunology 20110601 |
| Triamino pyrimidines and pyridines as histamine H(4) receptor modulators. | Bioorganic & medicinal chemistry letters 20110515 |
| Expression and functional properties of canine, rat, and murine histamine H₄ receptors in Sf9 insect cells. | Naunyn-Schmiedeberg's archives of pharmacology 20110501 |
| Agonist-biased signaling at the histamine H4 receptor: JNJ7777120 recruits β-arrestin without activating G proteins. | Molecular pharmacology 20110401 |
| Paradoxical stimulatory effects of the 'standard' histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors exhibiting functional selectivity. | Molecular pharmacology 20110401 |
| Histamine H(4) receptor antagonism inhibits allergen-specific T-cell responses mediated by human dendritic cells. | European journal of pharmacology 20110125 |
| Histamine H(4) receptor activation on human slan-dendritic cells down-regulates their pro-inflammatory capacity. | Immunology 20110101 |
| [Effect of histamine H4 receptor and its antagonist on allergic rhinitis in rats]. | Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20100601 |
| Molecular determinants of ligand binding to H4R species variants. | Molecular pharmacology 20100501 |
| Histamine stimulates human lung fibroblast migration. | Molecular and cellular biochemistry 20100401 |
| The histamine H4 receptor mediates inflammation and pruritus in Th2-dependent dermal inflammation. | The Journal of investigative dermatology 20100401 |
| Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma? | Pharmacology 20100101 |
| Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines. | Respiratory research 20100101 |
| Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor. | Molecular pharmacology 20091101 |
| Synthesis and structure-activity relationships of cyanoguanidine-type and structurally related histamine H4 receptor agonists. | Journal of medicinal chemistry 20091022 |
| 2,4-Diaminopyrimidines as histamine H4 receptor ligands--Scaffold optimization and pharmacological characterization. | Bioorganic & medicinal chemistry 20091015 |
| Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist. | The Journal of toxicological sciences 20091001 |
| The histamine H receptor as a new target for treatment of canine inflammatory skin diseases. | Veterinary dermatology 20091001 |
| A new generation of anti-histamines: Histamine H4 receptor antagonists on their way to the clinic. | Current opinion in drug discovery & development 20090901 |
| The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090601 |
| Effect of histamine H4 receptor antagonist on allergic rhinitis in mice. | International immunopharmacology 20090601 |
| Histamine H4 receptor antagonism reduces hapten-induced scratching behaviour but not inflammation. | Experimental dermatology 20090101 |
| Discovery of quinazolines as histamine H4 receptor inverse agonists using a scaffold hopping approach. | Journal of medicinal chemistry 20081225 |
| cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia. | Journal of medicinal chemistry 20081127 |
| Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands. | Journal of medicinal chemistry 20081023 |
| Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. | Journal of medicinal chemistry 20081023 |
| Phenylalanine 169 in the second extracellular loop of the human histamine H4 receptor is responsible for the difference in agonist binding between human and mouse H4 receptors. | The Journal of pharmacology and experimental therapeutics 20081001 |
| Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine. | Allergy 20081001 |
| Cloning and pharmacological characterization of the dog histamine H4 receptor. | European journal of pharmacology 20080911 |
| Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. | Journal of medicinal chemistry 20080612 |
| Histamine H(4) receptors regulate ACTH release in AtT-20 cells. | European journal of pharmacology 20080610 |
| Activation mechanism of the human histamine H4 receptor--an explicit membrane molecular dynamics simulation study. | Journal of chemical information and modeling 20080601 |
| Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor. | European journal of medicinal chemistry 20080501 |
| Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. | Journal of medicinal chemistry 20080424 |
| Histamine receptor H4R-selective ligands influence the STAT6 Transcription Activation Domain (TAD) and the DNA-binding. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080101 |
| Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. | The Journal of allergy and clinical immunology 20070801 |
| Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. | European journal of pharmacology 20070601 |
| The histamine H(4) receptor: a novel modulator of inflammatory and immune disorders. | Pharmacology & therapeutics 20070301 |
| Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. | The Journal of allergy and clinical immunology 20070101 |
| Role of histamine H3 and H4 receptors in mechanical hyperalgesia following peripheral nerve injury. | Neuroimmunomodulation 20070101 |
| Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives. | Journal of medicinal chemistry 20060727 |
| The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. | Journal of immunology (Baltimore, Md. : 1950) 20060601 |
| Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. | Journal of medicinal chemistry 20051229 |
| Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat. | European journal of pharmacology 20051017 |
| Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. | The Journal of pharmacology and experimental therapeutics 20050901 |
| Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. | Bioorganic & medicinal chemistry letters 20041101 |
| A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. | The Journal of pharmacology and experimental therapeutics 20040401 |
| The first potent and selective non-imidazole human histamine H4 receptor antagonists. | Journal of medicinal chemistry 20030911 |