Home Other Building Blocks (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

CAS No.:
409345-29-5
Catalog Number:
AG0037HA
Molecular Formula:
C20H23NO3
Molecular Weight:
325.4015
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$207
- +
10mg
98%
1 week
United States
$290
- +
25mg
98%
1 week
United States
$557
- +
50mg
98%
1 week
United States
$823
- +
Product Description
Catalog Number:
AG0037HA
Chemical Name:
(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
CAS Number:
409345-29-5
Molecular Formula:
C20H23NO3
Molecular Weight:
325.4015
MDL Number:
MFCD08690525
IUPAC Name:
3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl-(4-methoxycyclohexyl)methanone
InChI:
InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3
InChI Key:
QOTAQTRFJWLFCR-UHFFFAOYSA-N
SMILES:
COC1CCC(CC1)C(=O)c1ccc2c(c1)cc1c(n2)OCCC1
Properties
Complexity:
446  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
325.168g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
325.408g/mol
Monoisotopic Mass:
325.168g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
48.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.7  
Literature
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Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome. Psychopharmacology 20120101
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Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology 20100101
Role of the metabotropic glutamate receptor subtype 1 in the harmaline-induced tremor in rats. Journal of neural transmission (Vienna, Austria : 1996) 20090901
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JNJ16259685, a selective mGlu1 antagonist, suppresses isolation-induced aggression in male mice. European journal of pharmacology 20080531
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Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. Alcoholism, clinical and experimental research 20080201
Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats. Alcohol (Fayetteville, N.Y.) 20080201
Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task. Behavioural brain research 20051014
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists. Journal of medicinal chemistry 20050324
JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist. Neuropharmacology 20041201
Properties