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Harringtonin

CAS No.:
26833-85-2
Catalog Number:
AG0037GY
Molecular Formula:
C28H37NO9
Molecular Weight:
531.5947
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥95%
1 week
United States
$105
- +
5mg
≥95%
1 week
United States
$179
- +
10mg
≥95%
1 week
United States
$251
- +
Product Description
Catalog Number:
AG0037GY
Chemical Name:
Harringtonin
CAS Number:
26833-85-2
Molecular Formula:
C28H37NO9
Molecular Weight:
531.5947
MDL Number:
MFCD28978177
IUPAC Name:
1-O-[(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-yl] 4-O-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate
InChI:
InChI=1S/C28H37NO9/c1-26(2,32)8-9-28(33,15-22(30)35-4)25(31)38-24-21(34-3)14-27-7-5-10-29(27)11-6-17-12-19-20(37-16-36-19)13-18(17)23(24)27/h12-14,23-24,32-33H,5-11,15-16H2,1-4H3/t23-,24-,27+,28-/m1/s1
InChI Key:
HAVJATCHLFRDHY-KSZYUSJVSA-N
SMILES:
COC(=O)C[C@@](C(=O)O[C@@H]1C(=C[C@]23[C@@H]1c1cc4OCOc4cc1CCN3CCC2)OC)(CCC(O)(C)C)O
UNII:
088662H40F
NSC Number:
124147
Properties
Complexity:
953  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
531.247g/mol
Formal Charge:
0
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
531.602g/mol
Monoisotopic Mass:
531.247g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
124A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.5  
Literature
Title Journal
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
Computational selection of inhibitors of Abeta aggregation and neuronal toxicity. Bioorganic & medicinal chemistry 20090715
[In vitro effect of bortezomib alone or in combination with harringtonine or arsenic trioxide on proliferation and apoptosis of multidrug resistant leukemia cells]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20081101
[Analysis on prognosis and correlative factors of acute nonlymphocytic leukemia]. Zhongguo shi yan xue ye xue za zhi 20071201
[Induction of apoptosis in HL-60 cells by bortezomib alone or in combination with harringtonine in vitro]. Zhongguo shi yan xue ye xue za zhi 20070401
The cytotoxicity of naturally occurring styryl lactones. Phytomedicine : international journal of phytotherapy and phytopharmacology 20060201
[Preliminary study of DA or HA regimen chemotherapy for the treatment of refractory and relapsed paroxysmal nocturnal hemoglobinuria]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20040401
[Regulative function of extracelluar regulated protein kinases and telomerase in apoptosis of hepatocarcinomatous cell SMMC-7721]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20020801
[Quantitative analysis of Sokal's risk index in relation to 2 therapy protocols: their respective impact on clinical remission of chronic myeloid leukemia]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020801
BAPTA blocks DNA fragmentation and chromatin condensation downstream of caspase-3 and DFF activation in HT-induced apoptosis in HL-60 cells. Apoptosis : an international journal on programmed cell death 20010801
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products 19910101
Properties