Home Other Building Blocks 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol

CAS No.:
601514-19-6
Catalog Number:
AG0037GX
Molecular Formula:
C18H14N4O2
Molecular Weight:
318.3294
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
95%
In Stock USA
United States
$72
- +
10mg
95%
In Stock USA
United States
$110
- +
25mg
95%
In Stock USA
United States
$197
- +
50mg
95%
In Stock USA
United States
$340
- +
100mg
95%
In Stock USA
United States
$471
- +
Product Description
Catalog Number:
AG0037GX
Chemical Name:
3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
CAS Number:
601514-19-6
Molecular Formula:
C18H14N4O2
Molecular Weight:
318.3294
MDL Number:
MFCD09037535
IUPAC Name:
3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
InChI:
InChI=1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChI Key:
VPVLEBIVXZSOMQ-UHFFFAOYSA-N
SMILES:
Oc1cccc(c1)Oc1ncnc2c1cc([nH]2)c1cccc(c1)N
Properties
Complexity:
424  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
318.112g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
318.336g/mol
Monoisotopic Mass:
318.112g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
97A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
Involvement of insulin signalling pathway in methamphetamine-induced hyperphosphorylation of Tau. Toxicology 20180901
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. The Biochemical journal 20130415
Roles of glycogen synthase kinase 3 in Alzheimer's disease. Current Alzheimer research 20120901
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nature biotechnology 20111101
Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorganic & medicinal chemistry letters 20110701
GSK-3β negatively regulates megakaryocyte differentiation and platelet production from primary human bone marrow cells in vitro. Platelets 20110101
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 20071218
Synthetic small molecules that control stem cell fate. Proceedings of the National Academy of Sciences of the United States of America 20030624
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. Diabetes 20000201
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes 19990801
Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America 19930815
Properties