Effects of rhein on intestinal epithelial tight junction in IgA nephropathy.

World journal of gastroenterology 20130714

Chronic allograft nephropathy in rats is improved by the intervention of rhein.

Transplantation proceedings 20130101

Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor.

Journal of the American Chemical Society 20121031

Rhein induces apoptosis of human gastric cancer SGC-7901 cells via an intrinsic mitochondrial pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20121001

Novel molecularly imprinted polymers based on multiwalled carbon nanotubes with bifunctional monomers for solid-phase extraction of rhein from the root of kiwi fruit.

Journal of separation science 20120901

Bone-targeting glycol and NSAIDS ester prodrugs of rhein: synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies.

European journal of medicinal chemistry 20120901

A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector.

Chinese journal of integrative medicine 20120901

Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

Chinese journal of integrative medicine 20120901

Pharmacokinetic behavior of argirein, derived from rhein, is characterized as slow release and prolonged T₁/₂ of rhein in rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120815

Juglanthraquinone C, a novel natural compound derived from Juglans mandshurica Maxim, induces S phase arrest and apoptosis in HepG2 cells.

Apoptosis : an international journal on programmed cell death 20120801

Novel compounds and drugs and recent patents in treating multidrug-resistant and extensively drug-resistant tuberculosis.

Recent patents on anti-infective drug discovery 20120801

UPLC-MS/MS performing pharmacokinetic and biodistribution studies of rhein.

Journal of separation science 20120801

Activation of AQP4, p66Shc and endoplasmic reticulum stress is involved in inflammation by carrageenan and is suppressed by argirein, a derivative of rhein.

The Journal of pharmacy and pharmacology 20120801

Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples.

Biomedical chromatography : BMC 20120701

ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.

Inflammation 20120601

A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study.

Bioanalysis 20120601

The involvement of noradrenergic mechanisms in the suppressive effects of diazepam on the hypothalamic-pituitary-adrenal axis activity in female rats.

Croatian medical journal 20120601

Improvement of glucose tolerance by rhein with restored early-phase insulin secretion in db/db mice.

Journal of endocrinological investigation 20120601

The hydroalcoholic extract of Cassia alata (Linn.) leaves and its major compound rhein exhibits antiallergic activity via mast cell stabilization and lipoxygenase inhibition.

Journal of ethnopharmacology 20120507

Switching from enoxaparin to dabigatran etexilate: pharmacokinetics, pharmacodynamics, and safety profile.

European journal of clinical pharmacology 20120501

Protective effect of rhein against oxidative stress-related endothelial cell injury.

Molecular medicine reports 20120501

Cost-effectiveness of dabigatran etexilate for the prevention of stroke and systemic embolism in UK patients with atrial fibrillation.

Heart (British Cardiac Society) 20120401

[A comparative study on the absorption kinetics parameters of rhubarb free anthraquinones between normal dogs and dogs with severe acute pancreatitis].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120401

Toxicology study of senna (CAS No. 8013-11-4) in C57BL/6NTAC Mice and toxicology and carcinogenesis study of senna in genetically modified C3B6.129F1/Tac-Trp53tm1Brd haploinsufficient mice (Feed Studies).

National Toxicology Program genetically modified model report 20120401

A critical view on spike recovery for accuracy evaluation of analytical method for medicinal herbs.

Journal of pharmaceutical and biomedical analysis 20120325

Modeling mitochondrial dysfunctions in the brain: from mice to men.

Journal of inherited metabolic disease 20120301

Review of atrial fibrillation outcome trials of oral anticoagulant and antiplatelet agents.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301

International differences in self-reported health measures in 33 major metropolitan areas in Europe.

European journal of public health 20120201

Spectroscopic evidence for an oxazolone structure in anionic b-type peptide fragments.

Journal of the American Society for Mass Spectrometry 20120201

Synthesis and anti-tumor activity evaluation of rhein-aloe emodin hybrid molecule.

Natural product communications 20120201

Quantitative determination of rhein in human plasma by liquid chromatography-negative electrospray ionization tandem mass/mass spectrometry and the application in a pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis 20120105

Simultaneous determination of eight anthraquinones in Semen Cassiae by HPLC-DAD.

Phytochemical analysis : PCA 20120101

On the improvement of inhibitory response control and visuospatial attention by indirect and direct adrenoceptor agonists.

Psychopharmacology 20120101

The tibetan uterotonic zhi byed 11: mechanisms of action, efficacy, and historical use for postpartum hemorrhage.

Evidence-based complementary and alternative medicine : eCAM 20120101

Rhein induces apoptosis in human breast cancer cells.

Evidence-based complementary and alternative medicine : eCAM 20120101

Atrial natriuretic peptide enhances microvascular albumin permeability by the caveolae-mediated transcellular pathway.

Cardiovascular research 20120101

Comparison of dispersive liquid-liquid microextraction based on organic solvent and ionic liquid combined with high-performance liquid chromatography for the analysis of emodin and its metabolites in urine samples.

Journal of separation science 20120101

Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats.

Evidence-based complementary and alternative medicine : eCAM 20120101

Data mining of high density genomic variant data for prediction of Alzheimer's disease risk.

BMC medical genetics 20120101

How sensitive are estimates of carbon fixation in agricultural models to input data?

Carbon balance and management 20120101

Status of surfactants as penetration enhancers in transdermal drug delivery.

Journal of pharmacy & bioallied sciences 20120101

Guideline-based survey of outpatient COPD management by pulmonary specialists in Germany.

International journal of chronic obstructive pulmonary disease 20120101

Promotion of intestinal peristalsis by Bifidobacterium spp. capable of hydrolysing sennosides in mice.

PloS one 20120101

T4-related bacteriophage LIMEstone isolates for the control of soft rot on potato caused by 'Dickeya solani'.

PloS one 20120101

Safety and efficacy of dual therapy with GSK233705 and salmeterol versus monotherapy with salmeterol, tiotropium, or placebo in a crossover pilot study in partially reversible COPD patients.

International journal of chronic obstructive pulmonary disease 20120101

Predicting new molecular targets for rhein using network pharmacology.

BMC systems biology 20120101

Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans.

Evidence-based complementary and alternative medicine : eCAM 20120101

Catenarin Prevents Type 1 Diabetes in Nonobese Diabetic Mice via Inhibition of Leukocyte Migration Involving the MEK6/p38 and MEK7/JNK Pathways.

Evidence-based complementary and alternative medicine : eCAM 20120101

Nationalism, racism and propaganda in early Weimar Germany: contradictions in the campaign against the 'black horror on the Rhine'.

German history : the journal of the German History Society 20120101

Neuroprotective Effects of San-Huang-Xie-Xin-Tang in the MPP(+)/MPTP Models of Parkinson's Disease In Vitro and In Vivo.

Evidence-based complementary and alternative medicine : eCAM 20120101

Apoptotic effects of antilymphocyte globulins on human pro-inflammatory CD4+CD28- T-cells.

PloS one 20120101

The effects of supplementation with omega-3 polyunsaturated Fatty acids on cardiac rhythm: anti-arrhythmic, pro-arrhythmic, both or neither? It depends….

Frontiers in physiology 20120101

Astragalin from Cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast Saccharomyces cerevisiae.

International journal of molecular sciences 20120101

Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

Frontiers in microbiology 20120101

Bioguided Fractionation Shows Cassia alata Extract to Inhibit Staphylococcus epidermidis and Pseudomonas aeruginosa Growth and Biofilm Formation.

Evidence-based complementary and alternative medicine : eCAM 20120101

An overview of the evidence and mechanisms of herb-drug interactions.

Frontiers in pharmacology 20120101

Perfusion CT in colorectal cancer: comparison of perfusion parameters with tumor grade and microvessel density.

Korean journal of radiology 20120101

Induction of oxidative stress in kidney.

International journal of nephrology 20120101

The antiquity of the Rhine River: stratigraphic coverage of the dinotheriensande (eppelsheim formation) of the Mainz Basin (Germany).

PloS one 20120101

Semi-selective fatty acyl reductases from four heliothine moths influence the specific pheromone composition.

PloS one 20120101

Ultraviolet-B radiation and nitrogen affect nutrient concentrations and the amount of nutrients acquired by above-ground organs of maize.

TheScientificWorldJournal 20120101

Combined effect of subchondral drilling and hyaluronic acid with/without diacerein in full-thickness articular cartilage lesion in rabbits.

TheScientificWorldJournal 20120101

The neuroscience and psychophysiology of experience-based decisions: an introduction to the research topic.

Frontiers in psychology 20120101

Health technology assessment and its role in the future development of the Indian healthcare sector.

Perspectives in clinical research 20120101

[Determination of four anthraquinones in Sanhuang tablets by QAMS].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

LC-MS/MS method for the detection of common laxatives.

Methods in molecular biology (Clifton, N.J.) 20120101

Rhein inhibits integrin-linked kinase expression and regulates matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio in high glucose-induced epithelial-mesenchymal transition of renal tubular cell.

Biological & pharmaceutical bulletin 20120101

Rhein Reduces Fat Weight in db/db Mouse and Prevents Diet-Induced Obesity in C57Bl/6 Mouse through the Inhibition of PPARγ Signaling.

PPAR research 20120101

Compounded pimobendan for canine chronic degenerative mitral valve disease and pulmonary hypertension.

International journal of pharmaceutical compounding 20120101

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

PloS one 20120101

Rhein protects against obesity and related metabolic disorders through liver X receptor-mediated uncoupling protein 1 upregulation in brown adipose tissue.

International journal of biological sciences 20120101

Screening medicinal plants for the detection of novel antimalarial products applying the inhibition of β-hematin formation.

Journal of pharmaceutical and biomedical analysis 20111215

Novel rhein analogues as potential anticancer agents.

ChemMedChem 20111209

Pharmacokinetics screening for multi-components absorbed in the rat plasma after oral administration traditional Chinese medicine formula Yin-Chen-Hao-Tang by ultra performance liquid chromatography-electrospray ionization/quadrupole-time-of-flight mass spectrometry combined with pattern recognition methods.

The Analyst 20111207

An in vivo analysis of the therapeutic and synergistic properties of Chinese medicinal formula Yin-Chen-Hao-Tang based on its active constituents.

Fitoterapia 20111201

Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

Journal of medical microbiology 20111201

Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation.

Naunyn-Schmiedeberg's archives of pharmacology 20111201

Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.

Medical hypotheses 20111201

Neuroprotective and anti-oxidative effects of the hemodialysate actovegin on primary rat neurons in vitro.

Neuromolecular medicine 20111201

Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.

Journal of chromatography. A 20111021

Steady-state pharmacokinetics and tissue distribution of anthraquinones of Rhei Rhizoma in rats.

Journal of ethnopharmacology 20111011

A comparative study on the tissue distributions of rhubarb anthraquinones in normal and CCl4-injured rats orally administered rhubarb extract.

Journal of ethnopharmacology 20111011

Effects of Rhein lysinate on H2O2-induced cellular senescence of human umbilical vascular endothelial cells.

Acta pharmacologica Sinica 20111001

Anthraquinones and stilbenes from the roots and rhizomes of Rhubarb.

Journal of Asian natural products research 20111001

[Exploring the potential molecular target proteins of yinchenhao decoction using computer systemic biology].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20111001

LC, a novel estrone-rhein hybrid compound, promotes proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells.

Molecular and cellular endocrinology 20110915

Simultaneous quantification of twelve active components in Yiqing granule by ultra-performance liquid chromatography: application to quality control study.

Biomedical chromatography : BMC 20110901

[Effect of early intervention with rhein on islet function in db/db mice].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110901

[Studies on the interaction of rhein with bovine serum albumin by spectroscopic and voltammetric methods].

Guang pu xue yu guang pu fen xi = Guang pu 20110901

[Study on chemical constituents from the root of Hemerocallis citrina].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110901

Modifiers of mutant huntingtin aggregation: functional conservation of C. elegans-modifiers of polyglutamine aggregation.

PLoS currents 20110812

Rhein protects against acetaminophen-induced hepatic and renal toxicity.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801

Rhein, an inhibitor of adipocyte differentiation and adipogenesis.

Journal of Asian natural products research 20110801

TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanisms.

Cell death & disease 20110801

Rhein inhibits angiogenesis and the viability of hormone-dependent and -independent cancer cells under normoxic or hypoxic conditions in vitro.

Chemico-biological interactions 20110715

mTORC2 protein complex-mediated Akt (Protein Kinase B) Serine 473 Phosphorylation is not required for Akt1 activity in human platelets [corrected].

The Journal of biological chemistry 20110715

Structural basis for retinoic X receptor repression on the tetramer.

The Journal of biological chemistry 20110715

The use of response surface methodology to optimize the ultrasound-assisted extraction of five anthraquinones from Rheum palmatum L.

Molecules (Basel, Switzerland) 20110715

Simultaneous quantification of multiple active components from Xiexin decoction in rat plasma by LC-ESI-MS/MS: application in pharmacokinetics.

Biomedical chromatography : BMC 20110701

Anticandidal activity of Cassia fistula and its effect on ergosterol biosynthesis.

Pharmaceutical biology 20110701

Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

Cell death & disease 20110701

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression.

Pigment cell & melanoma research 20110601

CFTR chloride channel as a molecular target of anthraquinone compounds in herbal laxatives.

Acta pharmacologica Sinica 20110601

Hindered dissolution of fibrin formed under mechanical stress.

Journal of thrombosis and haemostasis : JTH 20110501

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.

Endocrinology 20110501

Rhein ameliorates fatty liver disease through negative energy balance, hepatic lipogenic regulation, and immunomodulation in diet-induced obese mice.

American journal of physiology. Endocrinology and metabolism 20110501

LC, a novel estrone-rhein hybrid compound, concurrently stimulates osteoprotegerin and inhibits receptor activator of NF-κB ligand (RANKL) and interleukin-6 production by human osteoblastic cells.

Molecular and cellular endocrinology 20110430

Anti-angiogenic effect and mechanism of rhein from Rhizoma Rhei.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

Effect of surfactant mixtures on skin structure and barrier properties.

Annals of biomedical engineering 20110401

Stability-indicating spectrophotometric and spectrodensitometric methods for the determination of diacerein in the presence of its degradation product.

Drug testing and analysis 20110401

Argirein alleviates diabetic nephropathy through attenuating NADPH oxidase, Cx43, and PERK in renal tissue.

Naunyn-Schmiedeberg's archives of pharmacology 20110301

Metabolic analysis of rhubarb extract by rat intestinal bacteria using liquid chromatography-tandem mass spectrometry.

Biomedical chromatography : BMC 20110301

[Tissue distribution of free anthraquinones in SD rats after orally administered extracts from raw and prepared rhubarbs].

Yao xue xue bao = Acta pharmaceutica Sinica 20110301

The Apoptotic Effect of the Hexane Extract of Rheum undulatum L. in Oral Cancer Cells through the Down-regulation of Specificity Protein 1 and Survivin.

Laboratory animal research 20110301

Pitfalls of vaccinations with WT1-, Proteinase3- and MUC1-derived peptides in combination with MontanideISA51 and CpG7909.

Cancer immunology, immunotherapy : CII 20110201

Big changes are coming in hepatitis C.

Current gastroenterology reports 20110201

Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein.

Acta pharmacologica Sinica 20110201

San-Huang-Xie-Xin-Tang Protects against Activated Microglia- and 6-OHDA-Induced Toxicity in Neuronal SH-SY5Y Cells.

Evidence-based complementary and alternative medicine : eCAM 20110101

Metabolism and pharmacokinetics of san-huang-xie-xin-tang, a polyphenol-rich chinese medicine formula, in rats and ex-vivo antioxidant activity.

Evidence-based complementary and alternative medicine : eCAM 20110101

Hypolipidemic effects of three purgative decoctions.

Evidence-based complementary and alternative medicine : eCAM 20110101

Effects of food and gender on the pharmacokinetics of rhein and emodin in rats after oral dosing with Da-Cheng-Qi decoction.

Phytotherapy research : PTR 20110101

Ocimum gratissimum Aqueous Extract Induces Apoptotic Signalling in Lung Adenocarcinoma Cell A549.

Evidence-based complementary and alternative medicine : eCAM 20110101

Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.

Bioorganic & medicinal chemistry 20110101

Hepcidin is an antibacterial, stress-inducible peptide of the biliary system.

PloS one 20110101

Proteome analyses of cellular proteins in methicillin-resistant Staphylococcus aureus treated with rhodomyrtone, a novel antibiotic candidate.

PloS one 20110101

Antiplatelet combinations for prevention of atherothrombotic events.

Vascular health and risk management 20110101

Development of novel Zn2+ loaded nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences.

PloS one 20110101

Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics?

BMC neurology 20110101

Improvement of type 2 diabetes mellitus in obese and non-obese patients after the duodenal switch operation.

Journal of obesity 20110101

Directed partial correlation: inferring large-scale gene regulatory network through induced topology disruptions.

PloS one 20110101

Prospective evaluation of prognostic factors uPA/PAI-1 in node-negative breast cancer: phase III NNBC3-Europe trial (AGO, GBG, EORTC-PBG) comparing 6×FEC versus 3×FEC/3×Docetaxel.

BMC cancer 20110101

Oral alitretinoin for the treatment of recalcitrant pityriasis rubra pilaris.

Case reports in dermatology 20110101

Somatostatin inhibits cell migration and reduces cell counts of human keratinocytes and delays epidermal wound healing in an ex vivo wound model.

PloS one 20110101

Construction of uricase-overproducing strains of Hansenula polymorpha and its application as biological recognition element in microbial urate biosensor.

BMC biotechnology 20110101

Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa.

PloS one 20110101

Major-effect alleles at relatively few loci underlie distinct vernalization and flowering variation in Arabidopsis accessions.

PloS one 20110101

Transcription Mapping of Embryonic Rat Brain Reveals EGR-1 Induction in SOX2 Neural Progenitor Cells.

Frontiers in molecular neuroscience 20110101

Emodin Induces Apoptotic Death in Murine Myelomonocytic Leukemia WEHI-3 Cells In Vitro and Enhances Phagocytosis in Leukemia Mice In Vivo.

Evidence-based complementary and alternative medicine : eCAM 20110101

Epigallocatechin-3-gallate suppresses the global interleukin-1beta-induced inflammatory response in human chondrocytes.

Arthritis research & therapy 20110101

Novel natural inhibitors of CYP1A2 identified by in silico and in vitro screening.

International journal of molecular sciences 20110101

Rhein lysinate induced S-phase arrest and increased the anti-tumor activity of 5-FU in HeLa cells.

The American journal of Chinese medicine 20110101

Cathepsin K deficiency in mice induces structural and metabolic changes in the central nervous system that are associated with learning and memory deficits.

BMC neuroscience 20110101

A targeted lipidomics approach to the study of eicosanoid release in synovial joints.

Arthritis research & therapy 20110101

Heteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathway.

Journal of neuroinflammation 20110101

Preventive effects and mechanisms of rhein on renal interstitial fibrosis in obstructive nephropathy.

Biological & pharmaceutical bulletin 20110101

Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.

PloS one 20110101

A single amino acid change within the R2 domain of the VvMYB5b transcription factor modulates affinity for protein partners and target promoters selectivity.

BMC plant biology 20110101

Hepatotoxicity or hepatoprotection? Pattern recognition for the paradoxical effect of the Chinese herb Rheum palmatum L. in treating rat liver injury.

PloS one 20110101

Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis.

International journal of biological sciences 20110101

Early reduction in painful physical symptoms is associated with improvements in long-term depression outcomes in patients treated with duloxetine.

BMC psychiatry 20110101

CDinFusion--submission-ready, on-line integration of sequence and contextual data.

PloS one 20110101

Error-related activity and correlates of grammatical plasticity.

Frontiers in psychology 20110101

Role of Magnetic Resonance Enterography in Differentiating between Fibrotic and Active Inflammatory Small Bowel Stenosis in Patients with Crohn's Disease.

Journal of clinical imaging science 20110101

Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis.

PloS one 20110101

Developmental mechanisms in articular cartilage degradation in osteoarthritis.

Arthritis 20110101

Retrograde rotational thrombectomy with the Rotarex catheter system: treatment option for an acute thrombotic occlusion of a subclavian artery.

Vascular health and risk management 20110101

In Vivo and In Vitro Study of a Polylactide-Fiber-Reinforced β-Tricalcium Phosphate Composite Cage in an Ovine Anterior Cervical Intercorporal Fusion Model.

International journal of biomaterials 20110101

Cornea lenticule viability and structural integrity after refractive lenticule extraction (ReLEx) and cryopreservation.

Molecular vision 20110101

Adjusting for COPD severity in database research: developing and validating an algorithm.

International journal of chronic obstructive pulmonary disease 20110101

Liver targeting effect of vinegar-baked Radix Bupleuri on rhein in rats.

Journal of ethnopharmacology 20101111

Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.

PLoS pathogens 20101001

[Effect of rhein treatment on first-phase insulin secretory function in db/db mice].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

Stroke Incidence and Survival in Ludwigshafen am Rhein, Germany: the Ludwigshafen Stroke Study (LuSSt).

Stroke 20100901

[Antimicrobial activity and chemical differences between the two chemotypes of rhubarbs].

Yao xue xue bao = Acta pharmaceutica Sinica 20100901

Temperature-assisted ionic liquid dispersive liquid-liquid microextraction combined with high performance liquid chromatography for the determination of anthraquinones in Radix et Rhizoma Rhei samples.

Talanta 20100815

Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers.

Journal of pharmaceutical and biomedical analysis 20100801

Anti-proliferative effect of rhein, an anthraquinone isolated from Cassia species, on Caco-2 human adenocarcinoma cells.

Journal of cellular and molecular medicine 20100701

Alteration of cell-wall porosity is involved in osmotic stress-induced enhancement of aluminium resistance in common bean (Phaseolus vulgaris L.).

Journal of experimental botany 20100701

Role of late maternal thyroid hormones in cerebral cortex development: an experimental model for human prematurity.

Cerebral cortex (New York, N.Y. : 1991) 20100601

Ultrasonic cell grinder extraction of anthraquinones from radix et rhizoma Rhei and determination by ultra-performance liquid chromatography.

Journal of separation science 20100601

Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation.

British journal of pharmacology 20100601

Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9.

International journal of oncology 20100501

Biosynthesis of unusual moth pheromone components involves two different pathways in the navel orangeworm, Amyelois transitella.

Journal of chemical ecology 20100501

Pharmacokinetic comparison in rats of six bioactive compounds between Da-Cheng-Qi decoction and its parent herbal medicines.

Natural product communications 20100501

[Effects of Rhein on the hypertrophy of renal proximal tubular epithelial cells induced by high glucose and angiotensin II in rats].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

[Liposomal encapsulation of free anthraquinones in rhizoma et radix rhei and its quality control].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401

Effects of diacerein at the molecular level in the osteoarthritis disease process.

Therapeutic advances in musculoskeletal disease 20100401

Mixed hemimicelles SPE based on CTAB-coated Fe3O4/SiO2 NPs for the determination of herbal bioactive constituents from biological samples.

Talanta 20100315

Long-term endometrial effects in postmenopausal women with early breast cancer participating in the Intergroup Exemestane Study (IES)--a randomised controlled trial of exemestane versus continued tamoxifen after 2-3 years tamoxifen.

Annals of oncology : official journal of the European Society for Medical Oncology 20100301

Emodin, aloe-emodin and rhein induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.

Anticancer research 20100301

Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

Bioorganic & medicinal chemistry 20100215

Qualitative and quantitative analysis of traditional Chinese medicine Niu Huang Jie Du Pill using ultra performance liquid chromatography coupled with tunable UV detector and rapid resolution liquid chromatography coupled with time-of-flight tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20100205

Occurrence and temporal variations of TMDD in the river Rhine, Germany.

Environmental science and pollution research international 20100201

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish.

Journal of leukocyte biology 20100201

[Rationality of commercial specification of rhubarb based on chemical analysis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201

Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy.

Planta medica 20100101

Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae).

Phytochemical analysis : PCA 20100101

Adaptation of Hansenula polymorpha to methanol: a transcriptome analysis.

BMC genomics 20100101

Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy.

Journal of Alzheimer's disease : JAD 20100101

Distinct cerebrospinal fluid amyloid beta peptide signatures in sporadic and PSEN1 A431E-associated familial Alzheimer's disease.

Molecular neurodegeneration 20100101

Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production.

Vascular pharmacology 20100101

Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis.

Journal of neuroinflammation 20100101

G-CSF, rt-PA and combination therapy after experimental thromboembolic stroke.

Experimental & translational stroke medicine 20100101

Highlights of the Didymellaceae: A polyphasic approach to characterise Phoma and related pleosporalean genera.

Studies in mycology 20100101

Stimuli of sensory-motor nerves terminate arterial contractile effects of endothelin-1 by CGRP and dissociation of ET-1/ET(A)-receptor complexes.

PloS one 20100101

Aging, Proteotoxicity, Mitochondria, Glycation, NAD and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox.

Frontiers in aging neuroscience 20100101

Ultra-fast analysis of plasma and intracellular levels of HIV protease inhibitors in children: a clinical application of MALDI mass spectrometry.

PloS one 20100101

The non-lemniscal auditory cortex in ferrets: convergence of corticotectal inputs in the superior colliculus.

Frontiers in neuroanatomy 20100101

Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies.

International journal of chronic obstructive pulmonary disease 20100101

Effects of immunomodulatory substances on phagocytosis of abeta(1-42) by human microglia.

International journal of Alzheimer's disease 20100101

Pro-inflammatory mechanisms of muscarinic receptor stimulation in airway smooth muscle.

Respiratory research 20100101

Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam.

Frontiers in neuroscience 20100101

Expression and function of human hemokinin-1 in human and guinea pig airways.

Respiratory research 20100101

Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes.

Journal of neuroinflammation 20100101

Evaluation of the soft tissue biocompatibility of MgCa0.8 and surgical steel 316L in vivo: a comparative study in rabbits.

Biomedical engineering online 20100101

Expression of connexin genes in the human retina.

BMC ophthalmology 20100101

Role of selective V2-receptor-antagonism in septic shock: a randomized, controlled, experimental study.

Critical care (London, England) 20100101

Tiotropium Respimat® improves physical functioning in chronic obstructive pulmonary disease.

International journal of chronic obstructive pulmonary disease 20100101

The laminin β1-competing peptide YIGSR induces a hypercontractile, hypoproliferative airway smooth muscle phenotype in an animal model of allergic asthma.

Respiratory research 20100101

Protein markers for insulin-producing beta cells with higher glucose sensitivity.

PloS one 20100101

Pharmacological properties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) meisn. leaves.

International journal of molecular sciences 20100101

Visible spectrophotometric estimation of diacerein in bulk and pharmaceutical dosage forms.

Journal of young pharmacists : JYP 20100101

New strategies for the treatment of hepatitis C virus infection and implications of resistance to new direct-acting antiviral agents.

Infection and drug resistance 20100101

Incorrect description of mode of excretion of linagliptin.

Drug, healthcare and patient safety 20100101

Effect of severe acute pancreatitis on pharmacokinetics of Da-Cheng-Qi Decoction components.

World journal of gastroenterology 20091221

Solubility, spectroscopic properties and photostability of Rhein/cyclodextrin inclusion complex.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091201

[MEKC-DAD fingerprint of Radix et Rhizoma Rhei].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

[Studies on chemical structure of complexes compounds formed by acid and alkaline components of pair medicines in decoction].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

Effect of local cold-pack application on systemic anabolic and inflammatory response to sprint-interval training: a prospective comparative trial.

European journal of applied physiology 20091101

Synthesis of anthraquinone-ibuprofen prodrugs with hydroxyapatite affinity and anti-inflammatory activity characteristics.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20091101

Metabolism and pharmacokinetics of anthraquinones in Rheum palmatum in rats and ex vivo antioxidant activity.

Planta medica 20091001

Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew.

Plant physiology and biochemistry : PPB 20090901

A major role for perifornical orexin neurons in the control of glucose metabolism in rats.

Diabetes 20090901

Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection.

Immunogenetics 20090901

[Effects of ranitidine on pharmacokinetics of rhein from Dachengqi Decoction in rats after oral administration].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20090901

Effective constituents in Xiexin Decoction for anti-inflammation.

Journal of ethnopharmacology 20090817

Targeting CpG DNA to screen and isolate anti-sepsis fraction and monomers from traditional Chinese herbs using affinity biosensor technology.

International immunopharmacology 20090801

[Anthraquinone contents in five processed products from Rheum palamatum].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

[Effect of processing on the chemical contents and hepatic and renal toxicity of rhubarb studied by canonical correlation analysis].

Yao xue xue bao = Acta pharmaceutica Sinica 20090801

Plant antimicrobial agents and their effects on plant and human pathogens.

International journal of molecular sciences 20090801

Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

Assessment of the renal protection and hepatotoxicity of rhubarb extract in rats.

Journal of ethnopharmacology 20090706

Laxative anthraquinone contents in fresh and cooked Senna siamea leaves.

The Southeast Asian journal of tropical medicine and public health 20090701

[Identification and determination of major constituents in Polygonum cuspidatum Sieb. et Zucc. by high performance liquid chromatography/electrospray ionization-ion trap-time-of-flight mass spectrometry].

Se pu = Chinese journal of chromatography 20090701

Sennoside B inhibits PDGF receptor signaling and cell proliferation induced by PDGF-BB in human osteosarcoma cells.

Life sciences 20090619

Rhein inhibits invasion and migration of human nasopharyngeal carcinoma cells in vitro by down-regulation of matrix metalloproteinases-9 and vascular endothelial growth factor.

Oral oncology 20090601

Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats.

Basic & clinical pharmacology & toxicology 20090601

[Simultaneous determination of anthraquinones in Liuwei'anxiao capsules by HPLC].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090601

Simultaneous HPLC-UV determination of rhein and aceclofenac in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

Pharmacological profiles of animal- and nonanimal-derived sulfated polysaccharides--comparison of unfractionated heparin, the semisynthetic glucan sulfate PS3, and the sulfated polysaccharide fraction isolated from Delesseria sanguinea.

Glycobiology 20090401

Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils.

PLoS pathogens 20090401

Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs.

Phytotherapy research : PTR 20090301

Differential inhibition of matrix metalloproteinases-2, -9, and -13 activities by selected anthraquinones.

Planta medica 20090301

Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal of bioscience and bioengineering 20090301

Quantitative HPLC determination and extraction of anthraquinones in Senna alata leaves.

Journal of chromatographic science 20090301

Inhibition of cytochrome P450 enzymes by rhein in rat liver microsomes.

Phytotherapy research : PTR 20090201

Profiling the metabolic differences of anthraquinone derivatives using liquid chromatography/tandem mass spectrometry with data-dependent acquisition.

Rapid communications in mass spectrometry : RCM 20090201

Anti-angiogenic effects of rhubarb and its anthraquinone derivatives.

Journal of ethnopharmacology 20090121

Rhein inhibits TNF-alpha-induced human aortic smooth muscle cell proliferation via mitochondrial-dependent apoptosis.

Journal of vascular research 20090101

Improved learning and memory in aged mice deficient in amyloid beta-degrading neutral endopeptidase.

PloS one 20090101

Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon.

PloS one 20090101

Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis.

Scandinavian journal of rheumatology 20090101

The roles of endoplasmic reticulum stress and Ca2+ on rhein-induced apoptosis in A-549 human lung cancer cells.

Anticancer research 20090101

Rhein lysinate suppresses the growth of breast cancer cells and potentiates the inhibitory effect of Taxol in athymic mice.

Anti-cancer drugs 20090101

Angiotensin-(1-7) and the g protein-coupled receptor MAS are key players in renal inflammation.

PloS one 20090101

Rhein induced apoptosis through the endoplasmic reticulum stress, caspase- and mitochondria-dependent pathways in SCC-4 human tongue squamous cancer cells.

In vivo (Athens, Greece) 20090101

Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.

Phytochemical analysis : PCA 20090101

Structure and function relationship of the autotransport and proteolytic activity of EspP from Shiga toxin-producing Escherichia coli.

PloS one 20090101

Predicting successful pulmonary vein isolation in patients with atrial fibrillation by brain natriuretic Peptide plasma levels.

Indian pacing and electrophysiology journal 20090101

Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats.

Diabetology & metabolic syndrome 20090101

Rhein lysinate suppresses the growth of tumor cells and increases the anti-tumor activity of Taxol in mice.

The American journal of Chinese medicine 20090101

Plant polycistronic precursors containing non-homologous microRNAs target transcripts encoding functionally related proteins.

Genome biology 20090101

Is senna laxative use associated to cathartic colon, genotoxicity, or carcinogenicity?

Journal of toxicology 20090101

A modified method for isolation of rhein from senna.

Indian journal of pharmaceutical sciences 20090101

Introduction.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20081127

Reminiscences and reflections on kuru, personal and scientific.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20081127

Why I joined the research laboratory of Prof. D. Carleton Gajdusek in 1968.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20081127

My 'brush' with kuru research.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20081127

Mixture for controlling insecticide-resistant malaria vectors.

Emerging infectious diseases 20081101

[Rhein lysinate induces apoptosis in breast cancer SK-Br-3 cells by inhibiting HER-2 signal pathway].

Yao xue xue bao = Acta pharmaceutica Sinica 20081101

Co-regulation of redox processes in freshwater wetlands as a function of organic matter availability?

The Science of the total environment 20081015

Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells.

Toxicology letters 20081001

Pharmacokinetics and tolerability (Study 1) with particular reference to ocular safety (Study 2) of tiotropium Respimat soft mist inhaler: findings from two dose-ranging studies in healthy men.

International journal of chronic obstructive pulmonary disease 20080901

Development and validation of a UPLC method for quality control of rhubarb-based medicine: fast simultaneous determination of five anthraquinone derivatives.

Journal of pharmaceutical and biomedical analysis 20080805

Phenols from the roots of Rheum palmatum attenuate chemotaxis in rat hepatic stellate cells.

Planta medica 20080801

Simultaneous determination of anthraquinones in radix Polygoni multiflori by capillary gas chromatography coupled with flame ionization and mass spectrometric detection.

Journal of chromatography. A 20080718

Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction.

Journal of pharmaceutical and biomedical analysis 20080715

Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: role in signaling TPA-induced growth arrest in ML-1 cells.

Journal of cellular physiology 20080701

Ultrasonic extraction and separation of anthraquinones from Rheum palmatum L.

Ultrasonics sonochemistry 20080701

Global transcriptional response of Staphylococcus aureus to rhein, a natural plant product.

Journal of biotechnology 20080630

Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.

European journal of medicinal chemistry 20080601

Development and validation of a sensitive LC-MS/MS method with electrospray ionization for quantitation of rhein in human plasma: application to a pharmacokinetic study.

Biomedical chromatography : BMC 20080601

Diacerhein downregulate proinflammatory cytokines expression and decrease the autoimmune diabetes frequency in nonobese diabetic (NOD) mice.

International immunopharmacology 20080601

Anti-proliferative effects of estrogen receptor-modulating compounds isolated from Rheum palmatum.

Archives of pharmacal research 20080601

Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPD.

International journal of chronic obstructive pulmonary disease 20080601

[Studies on chemical constituents and volatile oil of Xiaochengqi decoction].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501

[Regulative effects of aquaporin 4 expression by rhein in rhubarb to intestinal epithelial cell line LoVo].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080501

Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway.

British journal of pharmacology 20080401

A species barrier limits transmission of chronic wasting disease to mink (Mustela vison).

The Journal of general virology 20080401

Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation.

Journal of separation science 20080301

[Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080301

Purification of hydroxyanthraquinones and cinnamic acid from the roots of Rheum officinale Baill.

Journal of separation science 20080201

[A new qualitative and quantitative analytical method of chromatographic fingerprints: total quantum statistical moment].

Yao xue xue bao = Acta pharmaceutica Sinica 20080201

[Novel exploration of cathartic pharmacology induced by rhubarb].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

Determination of pharmacologically active compounds in root extracts of Cassia alata L. by use of high performance liquid chromatography.

Talanta 20080115

Optimization and validation of a chromatographic method for the simultaneous quantification of six bioactive compounds in Rhizoma et Radix Polygoni Cuspidati.

The Journal of pharmacy and pharmacology 20080101

Fungi have three tetraspanin families with distinct functions.

BMC genomics 20080101

Comparison of different real-time PCR chemistries and their suitability for detection and quantification of genetically modified organisms.

BMC biotechnology 20080101

Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.

Chinese medicine 20080101

Gait analysis does not correlate with clinical and MR imaging parameters in patients with symptomatic lumbar spinal stenosis.

BMC musculoskeletal disorders 20080101

Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling.

Arthritis research & therapy 20080101

A classification model to predict synergism/antagonism of cytotoxic mixtures using protein-drug docking scores.

BMC pharmacology 20080101

Consumption of Bt maize pollen expressing Cry1Ab or Cry3Bb1 does not harm adult green Lacewings, Chrysoperla carnea (Neuroptera: Chrysopidae).

PloS one 20080101

Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model.

BMC neuroscience 20080101

Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 cells.

The American journal of Chinese medicine 20080101

Anthraquinone pharmacokinetics in Xiexin decoction and the different combinations of its constituent herbs.

European journal of drug metabolism and pharmacokinetics 20080101

Modulatory effect of rhein on IL-1alpha-induced responses in human chondrocytes: a comparative study between antibody microarrays and specific ELISAs.

Biorheology 20080101

Protocol for German trial of Acyclovir and corticosteroids in Herpes-simplex-virus-encephalitis (GACHE): a multicenter, multinational, randomized, double-blind, placebo-controlled German, Austrian and Dutch trial [ISRCTN45122933].

BMC neurology 20080101

P38 MAP kinase inhibitors as potential therapeutics for the treatment of joint degeneration and pain associated with osteoarthritis.

Journal of inflammation (London, England) 20080101

Steady state bioequivalence of generic and innovator formulations of stavudine, lamivudine, and nevirapine in HIV-infected Ugandan adults.

PloS one 20080101

Large-scale separation of hydroxyanthraquinones from Rheum palmatum L. by pH-zone-refining counter-current chromatography.

Journal of chromatography. A 20071228

A dose-ranging study of tiotropium delivered via Respimat Soft Mist Inhaler or HandiHaler in COPD patients.

International journal of chronic obstructive pulmonary disease 20071201

Determination and pharmacokinetic comparison of rhein in rats after oral dosed with Da-Cheng-Qi decoction and Xiao-Cheng-Qi decoction.

Biomedical chromatography : BMC 20071101

Alternate SlyA and H-NS nucleoprotein complexes control hlyE expression in Escherichia coli K-12.

Molecular microbiology 20071101

[Effects of rhein on nonalcoholic steatohepatitis in rats].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20071101

Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

Increase of calnexin gene dosage boosts the secretion of heterologous proteins by Hansenula polymorpha.

FEMS yeast research 20071001

In situ synthesis of molecularly imprinted polymers on glass microspheres in a column.

Analytical and bioanalytical chemistry 20071001

Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db mice.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20071001

The combination of tiotropium and budesonide in the treatment of chronic obstructive pulmonary disease.

Journal of Korean medical science 20071001

Anti-cancer properties of anthraquinones from rhubarb.

Medicinal research reviews 20070901

Anthraquinone-2,6-disulfonic acid as a disease-modifying osteoarthritis drug: an in vitro and in vivo study.

Clinical orthopaedics and related research 20070801

Affinity chromatography with immobilized DNA stationary phase for biological fingerprinting analysis of traditional Chinese medicines.

Journal of chromatography. A 20070622

Modelling the 5-year cost effectiveness of tiotropium, salmeterol and ipratropium for the treatment of chronic obstructive pulmonary disease in Spain.

The European journal of health economics : HEPAC : health economics in prevention and care 20070601

Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb.

Natural product research 20070520

Study on the electrochemical behavior and differential pulse voltammetric determination of rhein using a nanoparticle composite film-modified electrode.

Bioelectrochemistry (Amsterdam, Netherlands) 20070501

Simultaneous quantification of five anthraquinones in rat plasma by high-performance liquid chromatography with fluorescence detection.

Biomedical chromatography : BMC 20070501

[Studies on chemical constituents of Prunella vulgaris].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070501

Application of 1-alkyl-3-methylimidazolium-based ionic liquids as background electrolyte in capillary zone electrophoresis for the simultaneous determination of five anthraquinones in Rhubarb.

Talanta 20070430

Anthranoid laxatives influence the absorption of poorly permeable drugs in human intestinal cell culture model (Caco-2).

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070401

Simultaneous determination of anthraquinones in rhubarb by high-performance liquid chromatography and capillary electrophoresis.

Journal of chromatography. A 20070323

Crystallization and preliminary X-ray analysis of AbsC, a novel regulator of antibiotic production in Streptomyces coelicolor.

Acta crystallographica. Section F, Structural biology and crystallization communications 20070301

Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.

British journal of cancer 20070115

Simultaneous determination of eight active components in Chinese medicine 'YIQING' capsule using high-performance liquid chromatography.

Journal of pharmaceutical and biomedical analysis 20070104

Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography.

Journal of pharmaceutical and biomedical analysis 20070104

Analysis of phenolic compounds in rhubarbs using liquid chromatography coupled with electrospray ionization mass spectrometry.

Journal of the American Society for Mass Spectrometry 20070101

Interaction of rhein with human serum albumin investigation by optical spectroscopic technique and modeling studies.

Biochimica et biophysica acta 20070101

Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine.

Journal of ethnobiology and ethnomedicine 20070101

Selection of reliable reference genes for qPCR studies on chondroprotective action.

BMC molecular biology 20070101

The role of Ca+2 on rhein-induced apoptosis in human cervical cancer Ca Ski cells.

Anticancer research 20070101

IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study.

Journal of immune based therapies and vaccines 20070101

[The involvement of G.Y. Rhein in the formation of the Russian forensic medical expert service].

Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny 20070101

Preparative isolation and purification of hydroxyanthraquinones from Rheum tanguticum Maxim. on normal phase silica gel: using a Flash Master Personal system.

Preparative biochemistry & biotechnology 20070101

Efficacy and safety of tiotropium in COPD patients in primary care--the SPiRiva Usual CarE (SPRUCE) study.

Respiratory research 20070101

Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells.

PloS one 20070101

Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNK-AP-1 dependent pathways.

Clinical and experimental rheumatology 20070101

Rhein induces apoptosis through induction of endoplasmic reticulum stress and Ca2+-dependent mitochondrial death pathway in human nasopharyngeal carcinoma cells.

Anticancer research 20070101

Bronchodilator response in patients with persistent allergic asthma could not predict airway hyperresponsiveness.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

Safety and efficacy of NT, an herbal supplement, in treating human obesity.

International journal of obesity (2005) 20061201

[Comparative studies on purgative potency among three spieces of certified rhubarb].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Determination of five anthraquinones in medicinal plants by capillary zone electrophoresis with beta-cyclodextrin addition.

Journal of chromatography. A 20060804

Simultaneous determination of baicalin, rhein and berberine in rat plasma by column-switching high-performance liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060621

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

High-performance liquid chromatographic method for simultaneous quantification of eight major biologically active ingredients in 'Da-Chai-Hu-Tang' preparation.

Biomedical chromatography : BMC 20060401

[Study on the selection of crude drugs of rhubarb dispensing granule].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

[The effects of tetramethylpyrazine in combination with rhein on proliferation and apoptosis in human liver cell L-02 induced by TGFb1 and TG].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20060301

[The content condition of effective composition in Sanhuang Xiexin decoction].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060301

Isolation and inhibitory activity against ERK phosphorylation of hydroxyanthraquinones from rhubarb.

Bioorganic & medicinal chemistry letters 20060201

Insulin sensitizing and alpha-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma.

Life sciences 20060125

The enhanced electrochemiluminescence of lucigenin by some hydroxyanthraquinones.

Talanta 20060115

Most recent developments in strategies to reduce the progression of structural changes in osteoarthritis: today and tomorrow.

Arthritis research & therapy 20060101

Inhibition of interleukin-1beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappaB and AP-1: potential mechanism for Diacerein effects in osteoarthritis.

Biorheology 20060101

IL-1beta synthesis by chondrocyte analyzed by 3D microscopy and flow cytometry: effect of Rhein.

Biorheology 20060101

Regulation of methanol utilisation pathway genes in yeasts.

Microbial cell factories 20060101

Spectroscopic characterization of effective components anthraquinones in Chinese medicinal herbs binding with serum albumins.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

Separation and determination of anthraquinones in Cassia obtusifolia (Leguminosae) by micellar electrokinetic capillary electrophoresis.

Journal of separation science 20051101

The influence of the sennosides on absorption of glycyrrhetic acid in rats.

Biological & pharmaceutical bulletin 20051001

[The pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

[A new isoflavone from Huoxue Yiqi Tang].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801

[Effects of rhein on activity of caspase-3 in kidney and cell apoptosis on the progression of renal injury in glomerulosclerosis].

Zhonghua yi xue za zhi 20050713

[Influence of processing rhubarb on it's anthraquinone contents].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

Effects and wavelet spectral entropy analysis of rhubarb extracts rhein on synaptic transmission in rat hippocampal ca1 area in vitro.

Chinese medical journal 20050520

Simultaneous determination of anthraquinones in Rhubarb by pressurized liquid extraction and capillary zone electrophoresis.

Electrophoresis 20050501

Simultaneous determination of anthraquinones, their 8-beta-D-glucosides, and sennosides of Rhei Rhizoma by capillary electrophoresis.

Chemical & pharmaceutical bulletin 20050501

[Progress in study on mechanisms of rhubarb in treating chronic renal failure].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050501

Screening procedure for detection of stimulant laxatives and/or their metabolites in human urine using gas chromatography-mass spectrometry after enzymatic cleavage of conjugates and extractive methylation.

Therapeutic drug monitoring 20050401

Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period.

Malaria journal 20050101

Peptide-based approaches to treat asthma, arthritis, other autoimmune diseases and pathologies of the central nervous system.

Archivum immunologiae et therapiae experimentalis 20050101

Pharmacokinetic of rhein in healthy male volunteers following oral and retention enema administration of rhubarb extract: a single dose study.

The American journal of Chinese medicine 20050101

Expedient total syntheses of rhein and diacerhein via Fries rearrangement.

The Journal of organic chemistry 20041210

Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process.

Life sciences 20041119

[Effects of combination therapy of rehin and tetramethylpyrazine on experimental hepatic fibrosis induced by tetrachloride].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20041101

[Simultaneous determination of 4 anthraquinones in Kuhuang injection by RP-HPLC].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

[Effects of rhein on the function of human mesangial cells in high glucose environment].

Yao xue xue bao = Acta pharmaceutica Sinica 20041101

Preparative isolation and purification of hydroxyanthraquinones and cinnamic acid from the chinese medicinal herb Rheum officinale Baill. by high-speed counter-current chromatography.

Journal of chromatography. A 20041015

Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungi.

Journal of agricultural and food chemistry 20041006

[Determination of active anthraquinones in Rheum and its tea preparations by micellar electrokinetic capillary electrophoresis].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040901

Determination of active ingredients in Huangdan Yinchen Keli by CZE with amperometric detection.

Journal of pharmaceutical and biomedical analysis 20040629

Determination of rhein, baicalin and berberine in traditional Chinese medicinal preparations by capillary electrophoresis with two-marker technique.

Biomedical chromatography : BMC 20040601

Stability control of senna leaves and senna extracts.

Planta medica 20040501

Identification and determination of active anthraquinones in Chinese teas by micellar electrokinetic capillary chromatography.

Biomedical chromatography : BMC 20040401

Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

Journal of ethnopharmacology 20040401

Inhibition of human tumor cell proliferation by novel anthraquinones from daylilies.

Life sciences 20040220

Rhein inhibits the growth and induces the apoptosis of Hep G2 cells.

Planta medica 20040101

Articular chondrocytes cultured in hypoxia: their response to interleukin-1beta and rhein, the active metabolite of diacerhein.

Biorheology 20040101

Exposure to malaria affects the regression of hepatosplenomegaly after treatment for Schistosoma mansoni infection in Kenyan children.

BMC medicine 20040101

Interaction of emodin, aloe-emodin, and rhein with human serum albumin: a fluorescence spectroscopic study.

Toxicology mechanisms and methods 20040101

Pulmonary tuberculosis due to Mycobacterium bovis subsp. caprae in captive Siberian tiger.

Emerging infectious diseases 20031101

Preparative separation of rhein from Chinese traditional herb by repeated high-speed counter-current chromatography.

Journal of chromatography. A 20031031

Rhein induces apoptosis in HL-60 cells via reactive oxygen species-independent mitochondrial death pathway.

Archives of biochemistry and biophysics 20031015

[Precipitation reaction between berberine and rheinic acid by capillary electrophoresis].

Yao xue xue bao = Acta pharmaceutica Sinica 20031001

Molecular and biochemical characterization of an enzyme responsible for the formation of hypericin in St. John's wort (Hypericum perforatum L.).

The Journal of biological chemistry 20030822

Simultaneous determination of hydroxyanthraquinones in rhubarb and experimental animal bodies by high-performance liquid chromatography.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030801

Rhein inhibits interleukin-1 beta-induced activation of MEK/ERK pathway and DNA binding of NF-kappa B and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis.

Inflammation 20030801

[Advances in the study on molecular mechanism of diabetic nephropathy treated with Rheum officinale].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030801

Differential modulation of the TRAIL receptors and the CD95 receptor in colon carcinoma cell lines.

British journal of cancer 20030721

[Studies on the chemical constituents of Dendrobium fimbriatum].

Yao xue xue bao = Acta pharmaceutica Sinica 20030701

Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors.

Bioorganic & medicinal chemistry letters 20030602

Relapsing fever-like spirochetes infecting European vector tick of Lyme disease agent.

Emerging infectious diseases 20030601

Pharmacokinetics of rhein from Onpi-to, an Oriental herbal medicine, in rats.

Biological & pharmaceutical bulletin 20030501

Rhein inhibits TPA-induced activator protein-1 activation and cell transformation by blocking the JNK-dependent pathway.

International journal of oncology 20030401

Rhein inhibits transforming growth factor beta1 induced plasminogen activator inhibitor-1 in endothelial cells.

Chinese medical journal 20030301

Determination of active components in rhubarb and study of their hydrophobicity by micellar electrokinetic chromatography.

Bioorganic & medicinal chemistry letters 20030224

Effects of rhein on human articular chondrocytes in alginate beads.

Biochemical pharmacology 20030201

Pharmacokinetic analysis of rhein in Rheum undulatum L.

Journal of ethnopharmacology 20030101

[Effect of Rhein on the development of hepatic fibrosis in rats].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20030101

Diacerein reduces the level of cartilage chondrocyte DNA fragmentation and death in experimental dog osteoarthritic cartilage at the same time that it inhibits caspase-3 and inducible nitric oxide synthase.

Clinical and experimental rheumatology 20030101

Solvent effects in permeation assessed in vivo by skin surface biopsy.

BMC dermatology 20030101

The lead extractor's toolbox: a review of current endovascular pacemaker and ICD lead extraction techniques.

Indian pacing and electrophysiology journal 20030101

Inducible nitric oxide synthase inhibitors of Chinese herbs III. Rheum palmatum.

Planta medica 20021001

[Determination of six effective components in Rheum by cyclodextrin modified micellar electrokinetic chromatography].

Yao xue xue bao = Acta pharmaceutica Sinica 20021001

[Determination of rhein in plasma of rat by HPLC/MS].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

Rhein inhibits liver fibrosis induced by carbon tetrachloride in rats.

Acta pharmacologica Sinica 20020801

Simultaneous determination of Aloe-emodin and Rhein by synchronous fluorescence spectroscopy.

Journal of pharmaceutical and biomedical analysis 20020720

Pharmacological studies of diacerein in animal models of inflammation, arthritis and bone resorption.

European journal of pharmacology 20020712

Diacerhein and rhein prevent interleukin-1beta-induced nuclear factor-kappaB activation by inhibiting the degradation of inhibitor kappaB-alpha.

Pharmacology & toxicology 20020701

Studies on the photostability and phototoxicity of aloe-emodin, emodin and rhein.

Die Pharmazie 20020601

Kinetics of the transhydrogenase reaction catalyzed by mitochondrial NADH:ubiquinone oxidoreductase (complex I).

Biochemistry. Biokhimiia 20020601

Cytotoxicity of rhein, the active metabolite of sennoside laxatives, is reduced by multidrug resistance-associated protein 1.

British journal of cancer 20020506

Reactive nitrogen species modulate the effects of rhein, an active component of senna laxatives, on human epithelium in vitro.

Journal of pediatric gastroenterology and nutrition 20020501

[Inhibitors of complex I and II of the mitochondrial respiratory chain].

Nihon rinsho. Japanese journal of clinical medicine 20020401

[Hairy-root culture of Polygonium multiflorum Thunb. and the production of its active constituents-anthraquinones].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20020101

In vitro study of intracellular IL-1beta production and beta1 integrins expression in stimulated chondrocytes--effect of rhein.

Biorheology 20020101

Cytotoxicity of natural hydroxyanthraquinones: role of oxidative stress.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

[Study on the quantitative change of anthraquinonoids of Rhei in the preparation of dachengqi].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020101

Analgesic effect of meloxicam in canine acute dermatitis--a pilot study.

Acta veterinaria Scandinavica 20020101

Rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1.

Acta pharmacologica Sinica 20011001

Production of monoclonal antibodies against a major purgative component, sennoside B, their characterization and use in ELISA.

The Analyst 20010801

[Inhibition of glucose transporter 1 overexpression in mesangial cells by rhein].

Zhonghua nei ke za zhi 20010801

Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.

Bioorganic & medicinal chemistry letters 20010723

[Treatment errors of metacarpal fractures. An analysis of expert testimony of the 'Committee for Medical Malpractice' of the North Rhine Physician's Council].

Der Orthopade 20010601

Diacerein suppresses the increase in plasma nitric oxide in rat adjuvant-induced arthritis.

European journal of pharmacology 20010511

In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.

Brain research 20010504

Inhibitory effects of Cassia tora L. on benzo[a]pyrene-mediated DNA damage toward HepG2 cells.

Journal of agricultural and food chemistry 20010501

[Rhein induces apoptosis in cancer cells and shows synergy with mitomycin].

Yao xue xue bao = Acta pharmaceutica Sinica 20010501

Rhein, an active metabolite of diacerein, down-regulates the production of pro-matrix metalloproteinases-1, -3, -9 and -13 and up-regulates the production of tissue inhibitor of metalloproteinase-1 in cultured rabbit articular chondrocytes.

Osteoarthritis and cartilage 20010401

Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.

The Journal of rheumatology 20010401

In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus.

Antiviral research 20010301

Determination of pKa values of anthraquinone compounds by capillary electrophoresis.

Electrophoresis 20010201

Glucose transporter in human glomerular mesangial cells modulated by transforming growth factor-beta and rhein.

Acta pharmacologica Sinica 20010201

Inhibition of the nitrosothiol production of cultured osteoarthritic chondrocytes by rhein, cortisol and diclofenac.

Osteoarthritis and cartilage 20010101

Rhein, an active metabolite of diacerein, suppresses the interleukin-1alpha-induced proteoglycan degradation in cultured rabbit articular chondrocytes.

Japanese journal of pharmacology 20010101

Effects of diacerein on indomethacin-induced gastric ulceration.

Pharmacology 20010101

Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.

European journal of pharmacology 20001208

Diacerhein and rhein reduce the ICE-induced IL-1beta and IL-18 activation in human osteoarthritic cartilage.

Osteoarthritis and cartilage 20000501

Clinical pharmacokinetics of diacerein.

Clinical pharmacokinetics 19981101

Rhein affects arylamine N-acetyltransferase activity in Helicobacter pylori from peptic ulcer patients.

Journal of applied toxicology : JAT 19980101

Pro- and anti-oxidant activities of the mitochondrial respiratory chain: factors influencing NAD(P)H-induced lipid peroxidation.

Biochimica et biophysica acta 19970116

Influence of rhein anthrone on peristaltic reflex of guinea-pig isolated ileum: involvement of prostaglandins.

British journal of pharmacology 19930101

Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus.

Antiviral research 19920101

Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat.

The Journal of pharmacy and pharmacology 19880901

Metabolism of 14C-rhein and 14C-rhein anthrone in rats.

Pharmacology 19880101