6-Methylmercaptopurine
| Title | Journal |
|---|---|
| Split-dose administration of thiopurine drugs: a novel and effective strategy for managing preferential 6-MMP metabolism. | Alimentary pharmacology & therapeutics 20120901 |
| High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment. | Alimentary pharmacology & therapeutics 20120501 |
| Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment. | Journal of Crohn's & colitis 20120201 |
| Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction. | Digestive diseases and sciences 20120101 |
| A validated HPLC method for the monitoring of thiopurine metabolites in whole blood in paediatric patients with inflammatory bowel disease. | International journal of immunopathology and pharmacology 20120101 |
| Use of thiopurine testing in the management of inflammatory bowel diseases in clinical practice: a worldwide survey of experts. | Inflammatory bowel diseases 20111201 |
| Allopurinol enhances the activity of hypoxanthine-guanine phosphoribosyltransferase in inflammatory bowel disease patients during low-dose thiopurine therapy: preliminary data of an ongoing series. | Nucleosides, nucleotides & nucleic acids 20111201 |
| Evaluating the use of metabolite measurement in children receiving treatment with a thiopurine. | Alimentary pharmacology & therapeutics 20111101 |
| Detection of thiopurine methyltransferase activity in lysed red blood cells by means of lab-on-a-chip surface enhanced Raman spectroscopy (LOC-SERS). | Analytical and bioanalytical chemistry 20110701 |
| Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease. | Inflammatory bowel diseases 20110601 |
| Steady-state of azathioprine during initiation treatment of pediatric inflammatory bowel disease. | Journal of Crohn's & colitis 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| A prospective evaluation of the impact of allopurinol in pediatric and adult IBD patients with preferential metabolism of 6-mercaptopurine to 6-methylmercaptopurine. | Journal of Crohn's & colitis 20101101 |
| Usefulness of the measurement of azathioprine metabolites in the assessment of non-adherence. | Journal of Crohn's & colitis 20101101 |
| Monitoring of azathioprine metabolites in pediatric patients with autoimmune hepatitis. | Therapeutic drug monitoring 20100801 |
| Limited stability of thiopurine metabolites in blood samples: relevant in research and clinical practise. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100601 |
| How should thiopurine treatment be monitored?--methodological aspects. | Nucleosides, nucleotides & nucleic acids 20100601 |
| Algorithms outperform metabolite tests in predicting response of patients with inflammatory bowel disease to thiopurines. | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20100201 |
| Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases. | Acta gastro-enterologica Belgica 20100101 |
| Patent watch. Drug metabolite claims are patentable. | Nature reviews. Drug discovery 20091101 |
| [Optimising azathioprine treatment: determination of thiopurine methyltransferase activity and thiopurine metabolites]. | Anales de pediatria (Barcelona, Spain : 2003) 20090201 |
| Initial clinical experience with allopurinol-thiopurine combination therapy in pediatric inflammatory bowel disease. | Inflammatory bowel diseases 20081201 |
| Population pharmacokinetic and pharmacogenetic analysis of 6-mercaptopurine in paediatric patients with acute lymphoblastic leukaemia. | British journal of clinical pharmacology 20081201 |
| Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. | European journal of gastroenterology & hepatology 20081201 |
| Regiospecific microwave-assisted synthesis and cytotoxic activity against human breast cancer cells of (RS)-6-substituted-7- or 9-(2,3-dihydro-5H-1,4-benzodioxepin-3-yl)-7H- or -9H-purines. | European journal of medicinal chemistry 20080801 |
| Stability of thiopurine metabolites: a potential analytical bias. | Clinical chemistry 20080101 |
| Optimizing drug therapy in inflammatory bowel disease. | Current gastroenterology reports 20071201 |
| 6-thioguanine nucleotide-adapted azathioprine therapy does not lead to higher remission rates than standard therapy in chronic active crohn disease: results from a randomized, controlled, open trial. | Clinical chemistry 20070701 |
| Thiopurine treatment in inflammatory bowel disease. | Clinical pharmacokinetics 20070101 |
| Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. | Journal of hepatology 20061001 |
| Exposure to thiopurine drugs through breast milk is low based on metabolite concentrations in mother-infant pairs. | British journal of clinical pharmacology 20061001 |
| Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside. | Biochemical pharmacology 20060928 |
| Evolution of thiopurine use in pediatric inflammatory bowel disease in an academic center. | Journal of pediatric gastroenterology and nutrition 20060901 |
| [HPLC determination and diversity analysis of thiopurine methyltransferase activity in human and pig]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20060501 |
| Liquid chromatography-tandem mass spectrometry analysis of erythrocyte thiopurine nucleotides and effect of thiopurine methyltransferase gene variants on these metabolites in patients receiving azathioprine/6-mercaptopurine therapy. | Clinical chemistry 20051101 |
| Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease. | Journal of gastroenterology and hepatology 20050801 |
| Determination of mercaptopurine and its four metabolites by large-volume sample stacking with polarity switching in capillary electrophoresis. | Electrophoresis 20050601 |
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | Chemical research in toxicology 20050601 |
| Monitoring of long-term thiopurine therapy among adults with inflammatory bowel disease. | Scandinavian journal of gastroenterology 20041101 |
| Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis. | European journal of gastroenterology & hepatology 20041101 |
| Improved HPLC methodology for monitoring thiopurine metabolites in patients on thiopurine therapy. | Clinical biochemistry 20040901 |
| The utility of 6-thioguanine metabolite levels in managing patients with inflammatory bowel disease. | The American journal of gastroenterology 20040901 |
| Clinical significance of azathioprine active metabolite concentrations in inflammatory bowel disease. | Gut 20040801 |
| Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity. | European journal of clinical pharmacology 20040101 |
| Real-time RT-PCR methodology for quantification of thiopurine methyltransferase gene expression. | European journal of clinical pharmacology 20030701 |
| Mercaptopurine metabolite results in clinical gastroenterology practice. | Alimentary pharmacology & therapeutics 20030101 |
| Measurement of thiopurine S-methyltransferase activity in human blood samples based on high-performance liquid chromatography: reference values in erythrocytes from children. | Annals of clinical biochemistry 20030101 |
| 6-Thioguanine seems promising in azathioprine- or 6-mercaptopurine-intolerant inflammatory bowel disease patients: a short-term safety assessment. | European journal of gastroenterology & hepatology 20030101 |
| Utility of measuring 6-methylmercaptopurine and 6-thioguanine nucleotide levels in managing inflammatory bowel disease patients treated with 6-mercaptopurine in a clinical practice setting. | Journal of clinical gastroenterology 20030101 |
| Determination of thiopurine S-methyltransferase phenotype using thin-layer chromatography and quantitative scanning. | European journal of clinical pharmacology 20020401 |
| Possible implication of thiopurine S-methyltransferase in occurrence of infectious episodes during maintenance therapy for childhood lymphoblastic leukemia with mercaptopurine. | Leukemia 20011101 |
| Determination of thiopurine methyltransferase activity in human erythrocytes by high-performance liquid chromatography: comparison with the radiochemical method. | Therapeutic drug monitoring 20011001 |
| Differing contribution of thiopurine methyltransferase to mercaptopurine versus thioguanine effects in human leukemic cells. | Cancer research 20010801 |
| Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood. | Journal of chromatography. B, Biomedical sciences and applications 20010605 |
| Therapeutic drug monitoring of azathioprine and 6-mercaptopurine metabolites in Crohn disease. | Scandinavian journal of gastroenterology 20010101 |
| Thiopurine methyltransferase activity in the erythrocytes of adults and children: and HPLC-linked assay. | Clinica chimica acta; international journal of clinical chemistry 19970318 |
| Purine analogs as potential anticytomegalovirus agents. | Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19690901 |