4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol
| Title | Journal |
|---|---|
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b. | The international journal of biochemistry & cell biology 20120901 |
| Inhibition of sphingosine kinase 1 enhances cytotoxicity, ceramide levels and ROS formation in liver cancer cells treated with selenite. | Biochemical pharmacology 20120901 |
| Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer. | Experimental biology and medicine (Maywood, N.J.) 20120701 |
| Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance. | Oncology reports 20120601 |
| Increasing ceramides sensitizes genistein-induced melanoma cell apoptosis and growth inhibition. | Biochemical and biophysical research communications 20120511 |
| Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer. | British journal of cancer 20120410 |
| Targeting sphingosine kinase-1 to inhibit melanoma. | Pigment cell & melanoma research 20120301 |
| Reversion of multidrug resistance by SKI-II in SGC7901/DDP cells and exploration of underlying mechanisms. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Sphingosine induces apoptosis in hippocampal neurons and astrocytes by activating caspase-3/-9 via a mitochondrial pathway linked to SDK/14-3-3 protein/Bax/cytochrome c. | Journal of cellular physiology 20110901 |
| Endogenous sphingosine 1-phosphate regulates spontaneous glutamate release from mossy fiber terminals via S1P(3) receptors. | Life sciences 20110718 |
| Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer. | Journal of molecular endocrinology 20110601 |
| Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways. | American journal of physiology. Lung cellular and molecular physiology 20110601 |
| Determination of sphingosine kinase 2 activity using fluorescent sphingosine by capillary electrophoresis. | Electrophoresis 20110601 |
| Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. | Journal of medicinal chemistry 20110526 |
| Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition. | Head & neck 20110201 |
| High-throughput screening assay for sphingosine kinase inhibitors in whole blood using RapidFire® mass spectrometry. | Journal of biomolecular screening 20110201 |
| Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase. | PloS one 20110101 |
| Sphingosine kinase 1 regulates the Akt/FOXO3a/Bim pathway and contributes to apoptosis resistance in glioma cells. | PloS one 20110101 |
| Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. | PloS one 20110101 |
| Evaluation of bioactive sphingolipids in 4-HPR-resistant leukemia cells. | BMC cancer 20110101 |
| Vessel-specific role of sphingosine kinase 1 in the vasoconstriction of isolated basilar arteries. | Pharmacological research 20101201 |
| Synthesis and bioactivity of sphingosine kinase inhibitors and their novel aspirinyl conjugated analogs. | European journal of medicinal chemistry 20100901 |
| Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. | Shock (Augusta, Ga.) 20100401 |
| Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. | American journal of nephrology 20100401 |
| 2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97). | Bioorganic & medicinal chemistry letters 20100301 |
| A novel mode of action of the putative sphingosine kinase inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl) thiazole (SKI II): induction of lysosomal sphingosine kinase 1 degradation. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101 |
| SKI-II, an inhibitor of sphingosine kinase, ameliorates antigen-induced bronchial smooth muscle hyperresponsiveness, but not airway inflammation, in mice. | Journal of pharmacological sciences 20100101 |
| A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells. | Cancer chemotherapy and pharmacology 20091001 |
| Role of sphingosine-1-phosphate (S1P) and the S1P(2) receptor in allergen-induced, mast cell-dependent contraction of rat lung parenchymal strips. | Naunyn-Schmiedeberg's archives of pharmacology 20091001 |
| Sphingosine kinase 1 is essential for proteinase-activated receptor-1 signalling in epithelial and endothelial cells. | The international journal of biochemistry & cell biology 20090701 |
| In vitro anti-leukaemia activity of sphingosine kinase inhibitor. | British journal of haematology 20090201 |
| Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury. | Shock (Augusta, Ga.) 20080701 |
| Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. | American journal of physiology. Lung cellular and molecular physiology 20080601 |
| Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. | Cardiovascular research 20080501 |
| Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. | The Prostate 20071101 |
| Disruption of retinoic acid receptor alpha reveals the growth promoter face of retinoic acid. | PloS one 20070101 |
| Pharmacologic manipulation of sphingosine kinase in retinal endothelial cells: implications for angiogenic ocular diseases. | Investigative ophthalmology & visual science 20061101 |
| Sphingosine kinase regulates voltage operated calcium channels in GH4C1 rat pituitary cells. | Cellular signalling 20060901 |
| Antitumor activity of sphingosine kinase inhibitors. | The Journal of pharmacology and experimental therapeutics 20060801 |
| Discovery and evaluation of inhibitors of human sphingosine kinase. | Cancer research 20030915 |
| Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes. | The Biochemical journal 20000901 |