Lonidamine
| Title | Journal |
|---|---|
| New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays. | European journal of medicinal chemistry 20131001 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. | Biochemical pharmacology 20121215 |
| Non-cytotoxic radiosensitizers in brain radiotherapy: journey till the first decade of this millennium. | Current cancer drug targets 20120301 |
| Polycystic kidney disease: a 2011 update. | Current opinion in nephrology and hypertension 20120301 |
| Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. | EMBO molecular medicine 20120201 |
| Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide and Mucuna macrocarpa Stem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Cancer metabolism: current perspectives and future directions. | Cell death & disease 20120101 |
| Coxiella burnetii induces apoptosis during early stage infection via a caspase-independent pathway in human monocytic THP-1 cells. | PloS one 20120101 |
| Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells. | Journal of pharmacology & pharmacotherapeutics 20120101 |
| Mechanism-based screen establishes signalling framework for DNA damage-associated G1 checkpoint response. | PloS one 20120101 |
| Implications of therapy-induced selective autophagy on tumor metabolism and survival. | International journal of cell biology 20120101 |
| Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation. | Biochemical pharmacology 20111201 |
| Lonidamine extends lifespan of adult Caenorhabditis elegans by increasing the formation of mitochondrial reactive oxygen species. | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110901 |
| Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer. | Nanomedicine : nanotechnology, biology, and medicine 20110801 |
| Monoamine carboxylate transporters are involved in BI-1-associated cancer metastasis in HT1080 colon fibrosarcoma cells. | International journal of oncology 20110701 |
| Metabolism and brain cancer. | Clinics (Sao Paulo, Brazil) 20110601 |
| Discovery of N-hydroxyindole-based inhibitors of human lactate dehydrogenase isoform A (LDH-A) as starvation agents against cancer cells. | Journal of medicinal chemistry 20110324 |
| Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells. | Molecular pharmaceutics 20110207 |
| Uptake of 2-NBDG as a method to monitor therapy response in breast cancer cell lines. | Breast cancer research and treatment 20110201 |
| Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect. | Perspectives in medicinal chemistry 20110101 |
| Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. | BMC cancer 20110101 |
| Enabling anticancer therapeutics by nanoparticle carriers: the delivery of Paclitaxel. | International journal of molecular sciences 20110101 |
| Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. | Frontiers in pharmacology 20110101 |
| Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer. | PloS one 20110101 |
| Mitochondrial peroxiredoxin III is a potential target for cancer therapy. | International journal of molecular sciences 20110101 |
| Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development. | Molecular biology international 20110101 |
| Adjudin-mediated Sertoli-germ cell junction disassembly affects Sertoli cell barrier function in vitro and in vivo. | The international journal of biochemistry & cell biology 20101101 |
| Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines. | The Journal of pharmacology and experimental therapeutics 20101001 |
| The fourth isoform of the adenine nucleotide translocator inhibits mitochondrial apoptosis in cancer cells. | The international journal of biochemistry & cell biology 20100501 |
| AF-2364 is a prospective spermicide candidate. | Asian journal of andrology 20100501 |
| A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity. | PLoS neglected tropical diseases 20100401 |
| Cancer as a metabolic disease. | Nutrition & metabolism 20100101 |
| Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial. | British journal of cancer 20091215 |
| International guidelines for management of metastatic breast cancer: combination vs sequential single-agent chemotherapy. | Journal of the National Cancer Institute 20090902 |
| Development of a yeast bio-assay to screen anti-mitochondrial drugs. | Current drug discovery technologies 20090901 |
| Modulation of cellular radiation responses by 2-deoxy-D-glucose and other glycolytic inhibitors: implications for cancer therapy. | Journal of cancer research and therapeutics 20090901 |
| Human cytomegalovirus US9 protein contains an N-terminal signal sequence and a C-terminal mitochondrial localization domain, and does not alter cellular sensitivity to apoptosis. | The Journal of general virology 20090501 |
| Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. | Blood 20090226 |
| Whole brain radiotherapy with radiosensitizer for brain metastases. | Journal of experimental & clinical cancer research : CR 20090101 |
| Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells. | Journal of translational medicine 20090101 |
| Effects of fotemustine or dacarbasine on a melanoma cell line pretreated with therapeutic proton irradiation. | Journal of experimental & clinical cancer research : CR 20090101 |
| Quality of life in brain metastases radiation trials: a literature review. | Current oncology (Toronto, Ont.) 20081001 |
| Optimizing radiotherapy of brain tumours by a combination of temozolomide & lonidamine. | The Indian journal of medical research 20080801 |
| The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. | Molecular and biochemical parasitology 20080401 |
| Glycosyl and polyalcoholic prodrugs of lonidamine. | Bioorganic & medicinal chemistry letters 20080401 |
| Canadian supportive care recommendations for the management of neutropenia in patients with cancer. | Current oncology (Toronto, Ont.) 20080101 |
| [Treatment and post-treatment with lonidamine in human colon carcinoma HT-29 cell line]. | Medicina 20080101 |
| Arsenic-based antineoplastic drugs and their mechanisms of action. | Metal-based drugs 20080101 |
| Neuropsychological testing and biomarkers in the management of brain metastases. | Radiation oncology (London, England) 20080101 |
| CFTR-dependent Cl- secretion in Xenopus laevis lung epithelium. | Respiratory physiology & neurobiology 20070815 |
| Evaluation of contraceptive activity of methanol extract of Dendrophthoe falcata stem in male albino rats. | Journal of ethnopharmacology 20070530 |
| Lonidamine affects testicular steroid hormones in immature mice. | Toxicology and applied pharmacology 20070515 |
| Mitomycin C and Vinorelbine for second-line chemotherapy in NSCLC--a phase II trial. | British journal of cancer 20070410 |
| Immunohistochemical profile of some neurotransmitters and neurotrophins in the seminiferous tubules of rats treated by lonidamine. | European journal of histochemistry : EJH 20070101 |
| The oncoprotein H-RasV12 increases mitochondrial metabolism. | Molecular cancer 20070101 |
| Pharmacologic inhibitors of extracellular signal-regulated kinase (ERKs) and c-Jun NH(2)-terminal kinase (JNK) decrease glutathione content and sensitize human promonocytic leukemia cells to arsenic trioxide-induced apoptosis. | Journal of cellular physiology 20061201 |
| The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. | Molecular pharmacology 20061201 |
| Ten years of experience with weekly chemotherapy in metastatic breast cancer patients: multivariate analysis of prognostic factors. | Anti-cancer drugs 20061101 |
| Chemosensitization by knockdown of adenine nucleotide translocase-2. | Cancer research 20060915 |
| Does granulocyte colony-stimulating factor worsen anemia in early breast cancer patients treated with epirubicin and cyclophosphamide? | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060701 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Emerging drug therapies for benign prostatic hyperplasia. | Expert opinion on emerging drugs 20060301 |
| [Antimitochondrial agents: a new class of anticancer agents]. | Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20060101 |
| Administration of zoledronic acid enhances the effects of docetaxel on growth of prostate cancer in the bone environment. | BMC cancer 20060101 |
| Surrogate markers and survival in women receiving first-line combination anthracycline chemotherapy for advanced breast cancer. | British journal of cancer 20051128 |
| Impact of five prophylactic filgrastim schedules on hematologic toxicity in early breast cancer patients treated with epirubicin and cyclophosphamide. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051001 |
| Lonidamine transiently affects spermatogenesis in pubertal CD1 mice. | Contraception 20051001 |
| Long-term effects of lonidamine on mouse testes. | Contraception 20051001 |
| Pharmacologic inhibitors of PI3K/Akt potentiate the apoptotic action of the antileukemic drug arsenic trioxide via glutathione depletion and increased peroxide accumulation in myeloid leukemia cells. | Blood 20050515 |
| Location of a common inhibitor binding site in the cytoplasmic vestibule of the cystic fibrosis transmembrane conductance regulator chloride channel pore. | The Journal of biological chemistry 20050311 |
| Mitomycin C, vinblastine and cisplatin (MVP): an active and well-tolerated salvage regimen for advanced breast cancer. | British journal of cancer 20050214 |
| Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas. | BMC cell biology 20050101 |
| The development of lonidamine for benign prostatic hyperplasia and other indications. | Reviews in urology 20050101 |
| Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. | Reviews in urology 20050101 |
| Clinical Evidence Supporting the Role of Lonidamine for the Treatment of BPH. | Reviews in urology 20050101 |
| Lonidamine causes inhibition of angiogenesis-related endothelial cell functions. | Neoplasia (New York, N.Y.) 20040901 |
| Contribution of caveolin-1 alpha and Akt to TNF-alpha-induced cell death. | American journal of physiology. Lung cellular and molecular physiology 20040701 |
| Apoptosis of human melanoma cells by a combination of lonidamine and radiation. | Journal of radiation research 20040601 |
| Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries. | The Journal of physiology 20040501 |
| Mitochondrial permeability transition-pore inhibition enhances functional recovery after long-time hypothermic heart preservation. | Transplantation 20031115 |
| Antioxidant MCI-186 inhibits mitochondrial permeability transition pore and upregulates Bcl-2 expression. | American journal of physiology. Heart and circulatory physiology 20031101 |
| Potentiation of antiproliferative drug activity by lonidamine in hepatocellular carcinoma cells. | Journal of chemotherapy (Florence, Italy) 20031001 |
| Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030915 |
| Second window of ischemic preconditioning regulates mitochondrial permeability transition pore by enhancing Bcl-2 expression. | Cardiovascular research 20030801 |
| Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis. | Biology of reproduction 20030501 |
| Phase II study of lonidamine and diazepam in the treatment of recurrent glioblastoma multiforme. | Journal of neuro-oncology 20030501 |
| Telomere dysfunction increases cisplatin and ecteinascidin-743 sensitivity of melanoma cells. | Molecular pharmacology 20030301 |
| Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. | Drugs of today (Barcelona, Spain : 1998) 20030301 |
| Ultralow doses of various drugs in chemotherapy of experimental tumors. | Bulletin of experimental biology and medicine 20030101 |
| Indazole inhibition of cystic fibrosis transmembrane conductance regulator Cl(-) channels in rat epididymal epithelial cells. | Biology of reproduction 20021201 |
| Mechanism of lonidamine inhibition of the CFTR chloride channel. | British journal of pharmacology 20021101 |
| Lonidamine solid dispersions: in vitro and in vivo evaluation. | Drug development and industrial pharmacy 20021101 |
| Hepatocytes transgenic for the full hepatitis C virus open reading frame are resistant to fas-induced cell death. | Annals of the New York Academy of Sciences 20021101 |
| Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells. | Life sciences 20021025 |
| Time to progression in metastatic breast cancer patients treated with epirubicin is not improved by the addition of either cisplatin or lonidamine: final results of a phase III study with a factorial design. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20021015 |
| Drug specific resistance to oxaliplatin is associated with apoptosis defect in a cellular model of colon carcinoma. | FEBS letters 20021009 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Recent studies on lonidamine, the lead compound of the antispermatogenic indazol-carboxylic acids. | Contraception 20020401 |
| [Are mitochondria targets of anticancer drugs responsible for apoptosis?]. | Annales de biologie clinique 20020101 |
| Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437. | Oncogene 20011115 |
| Two new male contraceptives exert their effects by depleting germ cells prematurely from the testis. | Biology of reproduction 20010801 |
| Expression of the cystic fibrosis transmembrane conductance regulator in rat spermatids: implication for the site of action of antispermatogenic agents. | Molecular human reproduction 20010801 |
| Enhancement of hyperglycemia-induced acidification of human melanoma xenografts with inhibitors of respiration and ion transport. | Academic radiology 20010701 |
| Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis. | Blood 20010615 |
| Analysis of lonidamine in rat serum and testis by high performance liquid chromatography. | Biomedical chromatography : BMC 20010201 |
| Paclitaxel, cisplatin and lonidamine in advanced ovarian cancer. A phase II study. | European journal of cancer (Oxford, England : 1990) 20010201 |
| Changes in cell volume and internal sodium concentration in HeLa cells during exponential growth and following lonidamine treatment. | European journal of cell biology 20010201 |
| Effect of lonidamine on alpha2-macroglobulin, hemopexin and alpha1-antitrypsin in the rat testis and epididymis. | Research communications in molecular pathology and pharmacology 20010101 |
| Testin induction: the role of cyclic 3',5'-adenosine monophosphate/protein kinase A signaling in the regulation of basal and lonidamine-induced testin expression by rat sertoli cells. | Biology of reproduction 20001201 |