The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells.

Chemico-biological interactions 20130925

Shikonin attenuates lung cancer cell adhesion to extracellular matrix and metastasis by inhibiting integrin β1 expression and the ERK1/2 signaling pathway.

Toxicology 20130607

Shikonin induces programmed necrosis-like cell death through the formation of receptor interacting protein 1 and 3 complex.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130501

In vitro and in vivo anticancer effects of Lithospermum erythrorhizon extract on B16F10 murine melanoma.

Journal of ethnopharmacology 20121121

Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Bioorganic & medicinal chemistry 20121115

Addition of β-lactoglobulin produces water-soluble shikonin.

Journal of agricultural and food chemistry 20121031

Novel multiple apoptotic mechanism of shikonin in human glioma cells.

Annals of surgical oncology 20120901

Shikonin and its derivatives: a patent review.

Expert opinion on therapeutic patents 20120901

Ionization of shikonin derivatives using negative-ion electrospray mass spectrometry: [M-H]- versus [M + e]•-.

Journal of mass spectrometry : JMS 20120501

[Antitumor effect research progress of shikonin and its derivatives].

Yao xue xue bao = Acta pharmaceutica Sinica 20120501

Theoretical investigation of the radical scavenging activity of shikonin and acylshikonin derivatives.

Journal of molecular modeling 20120401

Selective and slow-binding inhibition of shikonin derivatives isolated from Lithospermum erythrorhizon on glycosyl hydrolase 33 and 34 sialidases.

Bioorganic & medicinal chemistry 20120301

[Compare the composition and content of Arnebiae radix and the stem residues].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20120301

Synthesis and human telomeric G-quadruplex DNA-binding activity of glucosaminosides of shikonin/alkannin.

Bioorganic & medicinal chemistry letters 20120215

[Effects of shikonin on the proliferation and apoptosis of HL-60 cells].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120201

Chimeric advanced drug delivery nano systems (chi-aDDnSs) for shikonin combining dendritic and liposomal technology.

International journal of pharmaceutics 20120117

Shikonin derivatives protect immune organs from damage and promote immune responses in vivo in tumour-bearing mice.

Phytotherapy research : PTR 20120101

Compounds from Arnebia euchroma and their related anti-HCV and antibacterial activities.

Planta medica 20120101

Chemical inducers of heat shock proteins derived from medicinal plants and cytoprotective genes response.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20120101

Shikonin enhances efficacy of a gene-based cancer vaccine via induction of RANTES.

Journal of biomedical science 20120101

Nec-1 enhances shikonin-induced apoptosis in leukemia cells by inhibition of RIP-1 and ERK1/2.

International journal of molecular sciences 20120101

The critical role of redox homeostasis in shikonin-induced HL-60 cell differentiation via unique modulation of the Nrf2/ARE pathway.

Oxidative medicine and cellular longevity 20120101

Inhibitory effect of Shikonin on Candida albicans growth.

Biological & pharmaceutical bulletin 20120101

Shikonin, a Chinese plant-derived naphthoquinone, induces apoptosis in hepatocellular carcinoma cells through reactive oxygen species: A potential new treatment for hepatocellular carcinoma.

Free radical biology & medicine 20111215

Structure/antileishmanial activity relationship study of naphthoquinones and dependency of the mode of action on the substitution patterns.

Planta medica 20111201

Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.

Journal of medical microbiology 20111201

Glutathione-S-transferase enhances proliferation-migration and protects against shikonin-induced cell death in breast cancer cells.

The Kaohsiung journal of medical sciences 20111101

Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2.

Oncogene 20111020

Comparative study on enantiomeric excess of main akannin/shikonin derivatives isolated from the roots of three endemic Boraginaceae plants in China.

Biomedical chromatography : BMC 20111001

Shikonin inhibited mitogen-activated IL-4 and IL-5 production on EL-4 cells through downregulation of GATA-3 and c-Maf induction.

Life sciences 20110912

Semi-synthesis and antitumor activity of 6-isomers of 5, 8-O-dimethyl acylshikonin derivatives.

European journal of medicinal chemistry 20110801

[Rationality for dynamic detection of shikonin of Arnerbia euchroma in industrial process].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110701

Determination of the active constituents in Arnebia euchroma (Royle) Johnst. by ionic liquid-based ultrasonic-assisted extraction high-performance liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615

Modeling of hyperbranched polyesters as hosts for the multifunctional bioactive agent Shikonin.

Physical chemistry chemical physics : PCCP 20110614

Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications.

International journal of pharmaceutics 20110516

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition.

European journal of pharmacology 20110511

Shikonin inhibits tumor invasion via down-regulation of NF-κB-mediated MMP-9 expression in human ACC-M cells.

Oral diseases 20110501

[Study on dynamic changes and stability of effective components of Arnerbia euchroma].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

LeERF-1, a novel AP2/ERF family gene within the B3 subcluster, is down-regulated by light signals in Lithospermum erythrorhizon.

Plant biology (Stuttgart, Germany) 20110301

Shikonin inhibits adipogenesis by modulation of the WNT/β-catenin pathway.

Life sciences 20110214

Physico-chemical factors influencing the shikonin derivatives production in cell suspension cultures of Arnebia euchroma (Royle) Johnston, a medicinally important plant species.

Cell biology international 20110201

Assessment of shikonin for potential estrogenic activity by dual-luciferase reporter based bioluminescent measurements in vitro.

Die Pharmazie 20110201

Tigloylshikonin, a new minor Shikonin derivative, from the roots and the commercial root extract of lithospermum erythrorhizon.

Chemical & pharmaceutical bulletin 20110101

DNA damage induced by shikonin in the presence of Cu(II) ions: potential mechanism of its activity to apoptotic cell death.

Journal of Asian natural products research 20110101

Anti-adenovirus activities of shikonin, a component of Chinese herbal medicine in vitro.

Biological & pharmaceutical bulletin 20110101

Evaluation of the effectiveness of an ointment based on Alkannins/Shikonins on second intention wound healing in the dog.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 20110101

Detailed investigations on the solid cell culture and antimicrobial activities of the Iranian Arnebia euchroma.

Journal of biomedicine & biotechnology 20110101

Shikonin increases glucose uptake in skeletal muscle cells and improves plasma glucose levels in diabetic Goto-Kakizaki rats.

PloS one 20110101

Shikonin inhibits maturation of bone marrow-derived dendritic cells and suppresses allergic airway inflammation in a murine model of asthma.

British journal of pharmacology 20101201

Semi-synthesis and anti-tumor activity of 5,8-O-dimethyl acylshikonin derivatives.

European journal of medicinal chemistry 20101201

Shikonin inhibits the proliferation and induces the apoptosis of human HepG2 cells.

Canadian journal of physiology and pharmacology 20101201

Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer.

Breast cancer research and treatment 20101101

Shikonin protects mouse brain against cerebral ischemia/reperfusion injury through its antioxidant activity.

European journal of pharmacology 20100925

[Simultaneous determination of five active components in compound preparation of Dangguishuan by high-performance liquid chromatography].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

Synthesis and antitumor activity of new shikonin glycosides.

European journal of medicinal chemistry 20100701

Solid-phase extraction for purification of alkannin/shikonin samples and isolation of monomeric and dimeric fractions.

Analytical and bioanalytical chemistry 20100701

A novel antiestrogen agent Shikonin inhibits estrogen-dependent gene transcription in human breast cancer cells.

Breast cancer research and treatment 20100501

Shikonin reduces oedema induced by phorbol ester by interfering with IkappaBalpha degradation thus inhibiting translocation of NF-kappaB to the nucleus.

British journal of pharmacology 20100501

Shikonin inhibits fat accumulation in 3T3-L1 adipocytes.

Phytotherapy research : PTR 20100301

Targeting tumor proteasome with traditional Chinese medicine.

Current drug discovery technologies 20100301

[Role of NF-kappaB pathway in shikonin induced apoptosis in oral squamous cell carcinoma Tca-8113 cells].

Shanghai kou qiang yi xue = Shanghai journal of stomatology 20100201

Shikonin directly inhibits nitric oxide synthases: possible targets that affect thoracic aorta relaxation response and nitric oxide release from RAW 264.7 macrophages.

Journal of pharmacological sciences 20100101

Shikonin induces apoptosis through reactive oxygen species/extracellular signal-regulated kinase pathway in osteosarcoma cells.

Biological & pharmaceutical bulletin 20100101

Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling.

BMC genomics 20100101

Expression of 3-hydroxy-3-methylglutaryl-CoA reductase, p-hydroxybenzoate-m-geranyltransferase and genes of phenylpropanoid pathway exhibits positive correlation with shikonins content in arnebia [Arnebia euchroma (Royle) Johnston].

BMC molecular biology 20100101

Electrospun shikonin-loaded PCL/PTMC composite fiber mats with potential biomedical applications.

International journal of pharmaceutics 20091201

[Shikonin down-regulates CXCR4 expression and inhibits CXCL12-induced migratory responses in colorectal carcinoma cell line SW480].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20091101

Shikonin, an ingredient of Lithospermum erythrorhizon, down-regulates the expression of steroid sulfatase genes in breast cancer cells.

Cancer letters 20091018

Simultaneous densitometric determination of shikonin, acetylshikonin, and beta-acetoxyisovaleryl-shikonin in ultrasonic-assisted extracts of four Arnebia species using reversed-phase thin layer chromatography.

Journal of separation science 20090901

Effects of shikonin isolated from zicao on lupus nephritis in NZB/W F1 mice.

Biological & pharmaceutical bulletin 20090901

Bothriodumin, a shikonin derivative from Bothriospermum secundum Maxim.

Die Pharmazie 20090901

Dual role of shikonin in early and late stages of collagen type II arthritis.

Molecular biology reports 20090701

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo.

International journal of cancer 20090515

Identification of shikonin and its ester derivatives from the roots of Echium italicum L.

Journal of chromatography. A 20090410

Synthesis and antitumor activity of 6- and 2-(1-substituted-thio-4-methylpent-3-enyl)-5,8-dimethoxynaphthalene-1,4-diones.

European journal of medicinal chemistry 20090401

Naturally-occurring shikonin analogues--a class of necroptotic inducers that circumvent cancer drug resistance.

Cancer letters 20090218

Preparative isolation and purification of alkannin/shikonin derivatives from natural products by high-speed counter-current chromatography.

Biomedical chromatography : BMC 20090201

Synthesis and biological activity of novel shikonin analogues.

Bioorganic & medicinal chemistry letters 20090201

Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin.

Cancer science 20090201

Nitric oxide regulates shikonin formation in suspension-cultured Onosma paniculatum cells.

Plant & cell physiology 20090101

Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling.

Journal of ethnopharmacology 20081120

Shikonin, acetylshikonin, and isobutyroylshikonin inhibit VEGF-induced angiogenesis and suppress tumor growth in lewis lung carcinoma-bearing mice.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20081101

Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kappaB: neuroprotective implications.

Neuropharmacology 20081001

Shikonin inhibits IgE-mediated histamine release by human basophils and Syk kinase activity.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20081001

Expression analysis of light-regulated genes isolated from a full-length-enriched cDNA library of Onosma paniculatum cell cultures.

Journal of plant physiology 20080929

Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells.

Cell research 20080801

Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones.

European journal of medicinal chemistry 20080601

[Shikonin inhibits the proliferation of human airway smooth muscle cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080501

Alkannin/shikonin mixture from roots of Onosma echioides (L.) L.: extraction method study and quantification.

Journal of separation science 20080401

Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappaB pathway.

Phytotherapy research : PTR 20080301

Simultaneous determination of monomeric and oligomeric alkannins and shikonins by high-performance liquid chromatography-diode array detection-mass spectrometry.

Biomedical chromatography : BMC 20080201

Shikonin analogue (SA) 93/637 induces apoptosis by activation of caspase-3 in U937 cells.

Frontiers in bioscience : a journal and virtual library 20080101

Red pigment from Lithospermum erythrorhizon by supercritical CO2 extraction.

Journal of cosmetic science 20080101

Alkannins and shikonins: a new class of wound healing agents.

Current medicinal chemistry 20080101

Microencapsulation of extract containing shikonin using gelatin-acacia coacervation method: a formaldehyde-free approach.

Colloids and surfaces. B, Biointerfaces 20070801

Inhibition of tumor necrosis factor-alpha through selective blockade of Pre-mRNA splicing by shikonin.

Molecular pharmacology 20070601

Shikonin circumvents cancer drug resistance by induction of a necroptotic death.

Molecular cancer therapeutics 20070501

A new EGFR inhibitor induces apoptosis in colon cancer cells.

Biochemical and biophysical research communications 20070309

Human ACAT inhibitory effects of shikonin derivatives from Lithospermum erythrorhizon.

Bioorganic & medicinal chemistry letters 20070215

DMNQ S-64 induces apoptosis via caspase activation and cyclooxygenase-2 inhibition in human nonsmall lung cancer cells.

Annals of the New York Academy of Sciences 20070101

Shikonin-induced apoptosis involves caspase-3 activity in a human bladder cancer cell line (T24).

In vivo (Athens, Greece) 20070101

Effect of shikonin on human breast cancer cells proliferation and apoptosis in vitro.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061201

The shikonin derivatives and pyrrolizidine alkaloids in hairy root cultures of Lithospermum canescens (Michx.) Lehm.

Plant cell reports 20061001

SH-7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor.

International journal of cancer 20060901

A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases.

Molecular pharmacology 20060901

Cell growth and shikonin production of Arnebia euchroma in a periodically submerged airlift bioreactor.

Biotechnology letters 20060401

Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20060301

[Antitumor effect and mechanism of shikonin derivative SYUNZ-7].

Ai zheng = Aizheng = Chinese journal of cancer 20051201

Structure determination of oligomeric alkannin and shikonin derivatives.

Biomedical chromatography : BMC 20050901

Presence of peroxyradicals in cigarette smoke and the scavenging effect of shikonin, a naphthoquinone pigment.

Chemical & pharmaceutical bulletin 20050701

[Effect of shikonin, a phytocompound from Lithospermum erythrorhizon, on rat vascular smooth muscle cells proliferation and apoptosis in vitro].

Zhonghua yi xue za zhi 20050608

Phosphorylated extracellular signal-regulated kinase up-regulated p53 expression in shikonin-induced HeLa cell apoptosis.

Chinese medical journal 20050420

[Determination of shikonin derivatives in gromwell by reversed-phase high performance liquid chromatography].

Se pu = Chinese journal of chromatography 20050301

Ethylene induced shikonin biosynthesis in shoot culture of Lithospermum erythrorhizon.

Plant physiology and biochemistry : PPB 20050201

[Cytochrome P450 enzymes in biosyntheses of some plant secondary metabolites].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050101

[Biosynthesis of naphthoquinoine pigments in plants from Boraginaceae family in nature and in vitro culture].

Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

Study on the enantiomeric ratio of the pharmaceutical substances alkannin and shikonin.

Biomedical chromatography : BMC 20041201

Induction of apoptosis by shikonin through coordinative modulation of the Bcl-2 family, p27, and p53, release of cytochrome c, and sequential activation of caspases in human colorectal carcinoma cells.

Journal of agricultural and food chemistry 20041006

Study on isohexenylnaphthazarins polymerization in alkaline media.

Biomedical chromatography : BMC 20041001

Study on polymerization of the pharmaceutical substances isohexenylnaphthazarins.

Biomedical chromatography : BMC 20041001

Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis.

Journal of Asian natural products research 20040901

Immunomodulatory effect of shikonin derivatives isolated from Lithospermum canescens on cellular and humoral immunity in Balb/c mice.

Die Pharmazie 20040801

Encapsulation of isohexenylnaphthazarins in cyclodextrins.

Biomedical chromatography : BMC 20040501

[Production of shikonin by cell cultures of Lithospermum erythrorhizon].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040501

Evans Blue and other dyes as protein tyrosine phosphatase inhibitors.

Bioorganic & medicinal chemistry letters 20040419

Shikonins, phytocompounds from Lithospermum erythrorhizon, inhibit the transcriptional activation of human tumor necrosis factor alpha promoter in vivo.

The Journal of biological chemistry 20040213

p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells.

Journal of pharmacological sciences 20040201

Preparative high-speed counter-current chromatography for purification of shikonin from the Chinese medicinal plant Lithospermum erythrorhizon.

Journal of chromatography. A 20040109

Impairment of vascular function of rat thoracic aorta in an endothelium-dependent manner by shikonin/alkannin and derivatives isolated from roots of Macrotomia euchroma.

Planta medica 20040101

The inhibition of N-acetyltransferase activity and gene expression in human bladder cancer cells (T24) by shikonin.

In vivo (Athens, Greece) 20040101

Shikonin inhibits the growth and N-acetylation of 2-aminofluorene in Helicobacter pylori from ulcer patients.

Anticancer research 20040101

Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Biological & pharmaceutical bulletin 20031201

Involvement of reactive oxygen species, but not mitochondrial permeability transition in the apoptotic induction of human SK-Hep-1 hepatoma cells by shikonin.

Planta medica 20031201

Shikonin modulates cell proliferation by inhibiting epidermal growth factor receptor signaling in human epidermoid carcinoma cells.

Cancer letters 20031028

Inhibition of human immunodeficiency virus by a new class of pyridine oxide derivatives.

Antimicrobial agents and chemotherapy 20030901

Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation.

Phytotherapy research : PTR 20030501

Molecular cloning and characterization of a cDNA encoding a novel apoplastic protein preferentially expressed in a shikonin-producing callus strain of Lithospermum erythrorhizon.

Plant & cell physiology 20030401

Synthesis and release studies of shikonin-containing microcapsules prepared by the solvent evaporation method.

Journal of microencapsulation 20030101

Antimicrobial activities of naphthazarins from Arnebia euchroma.

Journal of natural products 20021201

Regulation of lithospermic acid B and shikonin production in Lithospermum erythrorhizon cell suspension cultures.

Chemical & pharmaceutical bulletin 20020801

High level expression of chorismate pyruvate-lyase (UbiC) and HMG-CoA reductase in hairy root cultures of Lithospermum erythrorhizon.

Plant & cell physiology 20020801

Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases.

Japanese journal of cancer research : Gann 20020801

Direct reaction between shikonin and thiols induces apoptosis in HL60 cells.

Biological & pharmaceutical bulletin 20020701

Alkannin and shikonin: effect on free radical processes and on inflammation - a preliminary pharmacochemical investigation.

Archiv der Pharmazie 20020601

Shikonin derivatives: synthesis and inhibition of human telomerase.

Bioorganic & medicinal chemistry letters 20020520

Cellular pharmacology studies of shikonin derivatives.

Phytotherapy research : PTR 20020501

Enhancement of shikonin production in single- and two-phase suspension cultures of Lithospermum erythrorhizon cells using low-energy ultrasound.

Biotechnology and bioengineering 20020405

Shikonin stimulates glucose uptake in 3T3-L1 adipocytes via an insulin-independent tyrosine kinase pathway.

Biochemical and biophysical research communications 20020405

Inhibitory effects of quinones on RNase H activity associated with HIV-1 reverse transcriptase.

Phytotherapy research : PTR 20020301

Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.

The Journal of biological chemistry 20020222

Granulomatous tissue formation of shikon and shikonin by air pouch method.

Biological & pharmaceutical bulletin 20010601

Shikonin production by p-fluorophenylalanine resistant cells of Lithospermum erythrorhizon.

Fitoterapia 20010501

A novel dark-inducible protein, LeDI-2, and its involvement in root-specific secondary metabolism in Lithospermum erythrorhizon.

Plant physiology 20010401

Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription.

Journal of biomolecular screening 20010401

Shikonin, a component of antiinflammatory Chinese herbal medicine, selectively blocks chemokine binding to CC chemokine receptor-1.

International immunopharmacology 20010201