Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats.

Diabetes/metabolism research and reviews 20120501

Increased poly(ADP-ribosyl)ation in peripheral leukocytes and the reperfused myocardium tissue of rats with ischemia/reperfusion injury: prevention by 3-aminobenzamide treatment.

Shock (Augusta, Ga.) 20120501

Poly(ADP-ribose) polymerase inhibition improves erectile function by activation of nitric oxide/cyclic guanosine monophosphate pathway in diabetic rats.

The journal of sexual medicine 20120501

Preventive Effect of Cichorium Intybus L. Two Extracts on Cerulein-induced Acute Pancreatitis in Mice.

International journal of preventive medicine 20120501

3'-5' phosphoadenosine phosphate is an inhibitor of PARP-1 and a potential mediator of the lithium-dependent inhibition of PARP-1 in vivo.

The Biochemical journal 20120415

Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.

European journal of medicinal chemistry 20120401

Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

Biochemical pharmacology 20120315

Picolinate ruthenium(II)-arene complex with in vitro antiproliferative and antimetastatic properties: comparison to a series of ruthenium(II)-arene complexes with similar structure.

Journal of inorganic biochemistry 20120301

Novel pathway of centrosome amplification that does not require DNA lesions.

Cancer science 20120201

ADP-ribose polymers localized on Ctcf-Parp1-Dnmt1 complex prevent methylation of Ctcf target sites.

The Biochemical journal 20120115

Poly(ADP-Ribose) polymerase 1 (PARP-1) regulates ribosomal biogenesis in Drosophila nucleoli.

PLoS genetics 20120101

Anti-inflammation effects of hydrogen saline in LPS activated macrophages and carrageenan induced paw oedema.

Journal of inflammation (London, England) 20120101

Post-Translational Modifications of Kaposi's Sarcoma-Associated Herpesvirus Regulatory Proteins - SUMO and KSHV.

Frontiers in microbiology 20120101

Niacinamide mitigated the acute lung injury induced by phorbol myristate acetate in isolated rat's lungs.

Journal of biomedical science 20120101

Adaptive response in mice exposed to 900 MHz radiofrequency fields: primary DNA damage.

PloS one 20120101

Poly (ADP-ribose) polymerase plays an important role in intermittent hypoxia-induced cell death in rat cerebellar granule cells.

Journal of biomedical science 20120101

Increased activity of cell surface peptidases in HeLa cells undergoing UV-induced apoptosis is not mediated by caspase 3.

International journal of molecular sciences 20120101

Chemical PARP inhibition enhances growth of Arabidopsis and reduces anthocyanin accumulation and the activation of stress protective mechanisms.

PloS one 20120101

[Suppressing poly(ADP-ribose)polymerase-1 inhibits tau phosphorylation in HEK293/tau441 cells].

Sheng li xue bao : [Acta physiologica Sinica] 20111225

Inhibition of poly(ADP-ribose) polymerase-1 attenuates the toxicity of carbon tetrachloride.

Journal of enzyme inhibition and medicinal chemistry 20111201

Chemotherapy sensitivity recovery of prostate cancer cells by functional inhibition and knock down of multidrug resistance proteins.

The Prostate 20111201

Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.

Molecular and cellular biochemistry 20111201

Morphological and functional evaluation of an animal model for the retinal degeneration induced by N-methyl-N-nitrosourea.

Anatomy & cell biology 20111201

Inhibition of PARP-1 by olaparib (AZD2281) increases the radiosensitivity of a lung tumor xenograft.

Molecular cancer therapeutics 20111001

Asbestos exposure affects poly(ADP-ribose) polymerase-1 activity: role in asbestos-induced carcinogenesis.

Mutagenesis 20110901

PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1.

Biochemical and biophysical research communications 20110826

Association of sperm morphology and the sperm deformity index (SDI) with poly (ADP-ribose) polymerase (PARP) cleavage inhibition.

Fertility and sterility 20110630

PARP inhibition prevents oxidative injury of bladder induced by acute urinary retention and subsequent emptying.

Apoptosis : an international journal on programmed cell death 20110601

[Effect of erythropoietin on proinflammatory factors of human monocytes and its mechanisms].

Zhongguo shi yan xue ye xue za zhi 20110601

Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins.

Neurotoxicity research 20110501

Lipoxygenases and poly(ADP-ribose) polymerase in amyloid beta cytotoxicity.

Neurochemical research 20110501

The poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide suppresses cell growth and migration, enhancing suppressive effects of cisplatin in osteosarcoma cells.

Oncology reports 20110501

Metal-based inhibition of poly(ADP-ribose) polymerase--the guardian angel of DNA.

Journal of medicinal chemistry 20110414

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death.

Cellular and molecular life sciences : CMLS 20110401

PARP inhibition restores erectile function by suppressing corporal smooth muscle apoptosis in diabetic rats.

The journal of sexual medicine 20110401

Synthesis and preliminary evaluation of selected 2-aryl-5(6)-nitro- 1H-benzimidazole derivatives as potential anticancer agents.

Archives of pharmacal research 20110201

Age-related loss of stress-induced nuclear proteasome activation is due to low PARP-1 activity.

Free radical biology & medicine 20110101

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.

Genome integrity 20110101

The CCCTC-binding factor (CTCF) of Drosophila contributes to the regulation of the ribosomal DNA and nucleolar stability.

PloS one 20110101

LRP16 integrates into NF-κB transcriptional complex and is required for its functional activation.

PloS one 20110101

Recombination phenotypes of the NCI-60 collection of human cancer cells.

BMC molecular biology 20110101

Low doses of 3-aminobenzamide, a poly(ADP-ribose) polymerase inhibitor, stimulate angiogenesis by regulating expression of urokinase type plasminogen activator and matrix metalloprotease 2.

Vascular cell 20110101

Promising molecular targeted therapies in breast cancer.

Indian journal of pharmacology 20110101

Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.

PloS one 20110101

Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell.

PloS one 20110101

Hepatoprotective effects of select water-soluble PARP inhibitors in a carbon tetrachloride model.

International journal of critical illness and injury science 20110101

Effects of 3-aminobenzamide on unilateral testicular ischemia-reperfusion injury: what is the role of PARP inhibition?

Canadian journal of physiology and pharmacology 20101201

Increased levels of p53 and PARP-1 in EL-4 cells probably related with the immune adaptive response induced by low dose ionizing radiation in vitro.

Biomedical and environmental sciences : BES 20101201

Targeting poly(ADP-ribose) polymerase activity for cancer therapy.

Cellular and molecular life sciences : CMLS 20101101

Dietary t10,c12-CLA but not c9,t11 CLA reduces adipocyte size in the absence of changes in the adipose renin-angiotensin system in fa/fa Zucker rats.

Lipids 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Poly(ADP-ribose) polymerase inhibitor, 3-aminobenzamide, protects against experimental immune ovarian failure in mice.

Reproductive biology 20101101

Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs.

Aging 20101001

Diabetic cystopathy is associated with PARP/JNK/mitochondrial apoptotic pathway-mediated bladder apoptosis.

Neurourology and urodynamics 20100901

Nickel modifies the cytotoxicity of hexavalent chromium in human dermal fibroblasts.

Toxicology letters 20100816

Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway.

Science (New York, N.Y.) 20100702

Fertilization capacity with rainbow trout DNA-damaged sperm and embryo developmental success.

Reproduction (Cambridge, England) 20100601

Effect of acute poly(ADP-ribose) polymerase inhibition by 3-AB on blood-brain barrier permeability and edema formation after focal traumatic brain injury in rats.

Journal of neurotrauma 20100601

Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine.

European journal of pharmacology 20100310

Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.

Biochemistry 20100216

Discovery and SAR of novel, potent and selective hexahydrobenzonaphthyridinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1).

Bioorganic & medicinal chemistry letters 20100115

Disruption of poly(ADP-ribosyl)ation mechanisms alters responses of Arabidopsis to biotic stress.

Plant physiology 20100101

PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.

Journal of pharmacological and toxicological methods 20100101

BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.

Journal of oncology 20100101

Relationship between DNA repair and formation of sister chromatid exchanges and chromatid aberrations under the influence of poly(ADP-ribose) polymerase inhibition by 3-aminobenzamide.

Cytogenetic and genome research 20100101

Modular insulators: genome wide search for composite CTCF/thyroid hormone receptor binding sites.

PloS one 20100101

A novel PARP inhibitor L-2286 in a rat model of impact acceleration head injury: an immunohistochemical and behavioral study.

International journal of molecular sciences 20100101

Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy.

PloS one 20100101

Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability.

Genome integrity 20100101

Clioquinol inhibits zinc-triggered caspase activation in the hippocampal CA1 region of a global ischemic gerbil model.

PloS one 20100101

Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.

Journal of nucleic acids 20100101

Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.

Journal of biomedical science 20100101

PolyADP-ribosylation is required for pronuclear fusion during postfertilization in mice.

PloS one 20100101

Targeting the osteosarcoma cancer stem cell.

Journal of orthopaedic surgery and research 20100101

Effects of inosine on reperfusion injury after cardiopulmonary bypass.

Journal of cardiothoracic surgery 20100101

PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function.

PloS one 20100101

BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide.

Gynecologic oncology 20091101

Inhibition of matrix metalloproteinase-2 by PARP inhibitors.

Biochemical and biophysical research communications 20091002

Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway.

Molecular pharmacology 20091001

Poly (ADP-Ribose) polymerase inhibition attenuates atherosclerotic plaque development in ApoE-/- mice with hyperhomocysteinemia.

Journal of atherosclerosis and thrombosis 20091001

Multiple mechanisms for hydrogen peroxide-induced apoptosis.

Annals of the New York Academy of Sciences 20090801

Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090729

Effects of 3-aminobenzamide on expressions of poly (ADP ribose) polymerase and apoptosis inducing factor in cardiomyocytes of rats with acute myocardial infarction.

Chinese medical journal 20090605

Spatiotemporal activation of caspase-dependent and -independent pathways in staurosporine-induced apoptosis of p53wt and p53mt human cervical carcinoma cells.

Biology of the cell 20090604

Apoptosis-inducing factor plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.

Apoptosis : an international journal on programmed cell death 20090601

Roles of inhibitors of poly(ADP-ribose) polymerase in protecting rat RINm5F cell line against free fatty acid-induced apoptosis.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090601

Evaluation of poly(ADP-ribose) polymerase cleavage (cPARP) in ejaculated human sperm fractions after induction of apoptosis.

Fertility and sterility 20090501

Identification and expansion of human osteosarcoma-cancer-stem cells by long-term 3-aminobenzamide treatment.

Journal of cellular physiology 20090501

Diabetic cardiomyopathy.

Clinical science (London, England : 1979) 20090501

Poly (ADP-ribose) polymerase inhibition improves endothelial dysfunction induced by hyperhomocysteinemia in rats.

Cardiovascular drugs and therapy 20090401

Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage.

The Journal of biological chemistry 20090313

Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.

Fertility and sterility 20090301

Does the 3-aminobenzamide effect on bacterial translocation affect experimental acute necrotizing pancreatitis?

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20090301

Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

Journal of medicinal chemistry 20090212

PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts.

Cardiovascular research 20090101

Structure-activity relationship analysis of cytotoxic cyanoguanidines: selection of CHS 828 as candidate drug.

BMC research notes 20090101

Recent advances in systemic therapy. When HER2 is not the target: advances in the treatment of HER2-negative metastatic breast cancer.

Breast cancer research : BCR 20090101

Poly[ADP-ribose] polymerase-1 expression is related to cold ischemia, acute tubular necrosis, and delayed renal function in kidney transplantation.

PloS one 20090101

3-aminobenzamide, a poly ADP ribose polymerase inhibitor, attenuates renal ischemia/reperfusion injury.

Renal failure 20090101

Microglial involvement in neuroplastic changes following focal brain ischemia in rats.

PloS one 20090101

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes.

Reproductive biology and endocrinology : RB&E 20090101

Systemic administration of lipopolysaccharide impairs glutathione redox state and object recognition in male mice. The effect of PARP-1 inhibitor.

Folia neuropathologica 20090101

Transcriptional regulation of mouse mu opioid receptor gene in neuronal cells by poly(ADP-ribose) polymerase-1.

Journal of cellular and molecular medicine 20081201

Low concentration of arsenite exacerbates UVR-induced DNA strand breaks by inhibiting PARP-1 activity.

Toxicology and applied pharmacology 20081001

The nucleosome-remodeling ATPase ISWI is regulated by poly-ADP-ribosylation.

PLoS biology 20081001

Meta-iodobenzylguanidine, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents neointimal hyperplasia.

The Journal of pharmacology and experimental therapeutics 20080901

PARP mediates structural alterations in diabetic cardiomyopathy.

Journal of molecular and cellular cardiology 20080901

CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery.

The Journal of biological chemistry 20080808

Ischemic and peroxynitrite preconditioning effects in chronic hypoxic rat lung.

Experimental lung research 20080801

Effect of 3-amino benzamide, a poly(adenosine diphosphate-ribose) polymerase inhibitor, in experimental caustic esophageal burn.

Journal of pediatric surgery 20080801

Inhibition of poly(ADP-ribose) polymerase (PARP) influences the mode of sulfur mustard (SM)-induced cell death in HaCaT cells.

Archives of toxicology 20080701

Non-enzymatic fast repair of DNA oxidative damage might also exist in cells.

Cell biology international 20080601

Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications.

Canadian journal of physiology and pharmacology 20080601

Induction of cytogenetic adaptive response in spermatogonia and spermatocytes by pre-exposure of mouse testis to low-dose (12)C(6+) ions.

Mutation research 20080531

Poly(adp-ribose) polymerase-1 regulates Tracp gene promoter activity during RANKL-induced osteoclastogenesis.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20080401

1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages.

Archivum immunologiae et therapiae experimentalis 20080401

TcPARP: A DNA damage-dependent poly(ADP-ribose) polymerase from Trypanosoma cruzi.

International journal for parasitology 20080301

Effects of poly(ADP-ribose) polymerase inhibition in bladder damage caused by cyclophosphamide in rats.

Experimental biology and medicine (Maywood, N.J.) 20080301

Combinatorial-approached neuroprotection using pan-caspase inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor following experimental stroke in rats; is there additional benefit?

Brain research 20080221

PARP activation and the alteration of vasoactive factors and extracellular matrix protein in retina and kidney in diabetes.

Diabetes/metabolism research and reviews 20080101

Possible involvement of 12-lipoxygenase activation in glucose-deprivation/reload-treated neurons.

Neuroscience letters 20071218

Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.

European journal of pharmacology 20071114

Activation of telomerase by ionizing radiation: differential response to the inhibition of DNA double-strand break repair by abrogation of poly (ADP-ribosyl)ation, by LY294002, or by Wortmannin.

International journal of radiation oncology, biology, physics 20071101

Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.

The Journal of nutrition 20071001

Strain-dependent induction of epithelial cell oncosis by Campylobacter jejuni is correlated with invasion ability and is independent of cytolethal distending toxin.

Microbiology (Reading, England) 20070901

Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling.

Neuroreport 20070806

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.

Toxicology letters 20070801

Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation.

Neuroscience 20070713

Xanthomonas caspase displays an inherent PARP-like activity.

FEMS microbiology letters 20070701

Retrodifferentiation and rejuvenation of senescent monocytic cells requires PARP-1.

Experimental gerontology 20070601

Enhanced poly(ADP-ribose) polymerase-1 activation contributes to recombinant tissue plasminogen activator-induced aggravation of ischemic brain injury in vivo.

Journal of neuroscience research 20070601

Apoptosis in sulfur mustard treated A549 cell cultures.

Life sciences 20070530

Combination therapy of poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide and gemcitabine shows strong antitumor activity in pancreatic cancer cells.

Journal of gastroenterology and hepatology 20070501

Ischemia/reperfusion of the liver induces heart injury in rats.

Transplantation proceedings 20070501

Oxidative stress-induced poly(ADP-ribosyl)ation in chick limb bud-derived chondrocytes.

International journal of molecular medicine 20070401

PPAR alpha agonists improve renal preservation in kidneys subjected to chronic in vitro perfusion: interaction with mannitol.

Transplant international : official journal of the European Society for Organ Transplantation 20070301

The involvement of ATP produced via (ADP-Ribose)n in the maintenance of DNA replication apparatus during DNA repair.

Biological & pharmaceutical bulletin 20070301

Poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide rescues N-methyl-N-nitrosourea-induced photoreceptor cell apoptosis in Sprague-Dawley rats through preservation of nuclear factor-kappaB activity.

Experimental eye research 20070201

Lactate down-regulates cellular poly(ADP-ribose) formation in cultured human skin fibroblasts.

European journal of clinical investigation 20070201

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells.

BMC genomics 20070101

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition.

BMC molecular biology 20070101

Poly(ADP-ribose) polymerase offers protection against oxidative and alkylation damage to the nuclear and mitochondrial genomes of the retinal pigment epithelium.

Ophthalmic research 20070101

A general framework for quantifying the effects of DNA repair inhibitors on radiation sensitivity as a function of dose.

Theoretical biology & medical modelling 20070101

Inhibition of Poly(ADP-ribose)polymerase impairs Epstein Barr Virus lytic cycle progression.

Infectious agents and cancer 20070101

[The influence of chemical inhibitors of DNA repair on the recovery of mammalian cell damages induced by ionizing radiation].

Radiatsionnaia biologiia, radioecologiia 20070101

PARP inhibitors accelerate N-methyl-N-nitrosourea-induced cataractogenesis in Sprague-Dawley rats.

In vivo (Athens, Greece) 20070101

GSK-3beta and oxidative stress in aged brain. Role of poly(ADP- -ribose) polymerase-1.

Folia neuropathologica 20070101

[Poly(ADP-ribosa)polymerase--the relationships with life span and carcinogenesis].

Advances in gerontology = Uspekhi gerontologii 20070101

Effects of poly(ADP-ribose) polymerase inhibition on dysfunction of non-adrenergic non-cholinergic neurotransmission in gastric fundus in diabetic rats.

Nitric oxide : biology and chemistry 20061201

Poly(ADP-ribose) polymerase-1 inhibition protects the brain against systemic inflammation.

Neurochemistry international 20061201

Poly(ADP-ribose)polymerase inhibition decreases angiogenesis.

Biochemical and biophysical research communications 20061201

Molecular determinants involved in the increase of damage-induced apoptosis and delay of secondary necrosis due to inhibition of mono(ADP-ribosyl)ation.

Annals of the New York Academy of Sciences 20061201

Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis.

Biochemical and biophysical research communications 20061117

Effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) polymerase, in a mouse model of acute pancreatitis induced by cerulein.

European journal of pharmacology 20061107

Inhibition of poly(ADP-ribose)polymerase does not affect the recombination events in CHO xrs6 and wild type cells.

Radiation and environmental biophysics 20061101

Preconditioning effects of peroxynitrite in the rat lung.

Pharmacological research 20061101

Helicobacter pylori induces mono-(adenosine 5'-diphosphate)-ribosylation in human gastric adenocarcinoma.

International journal of oncology 20061001

Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents.

European journal of medical research 20060830

In vivo exposure of swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins.

Molecular and cellular biochemistry 20060801

Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors.

The Journal of pharmacology and experimental therapeutics 20060801

Adenosine2A receptor vasodilation of rat preglomerular microvessels is mediated by EETs that activate the cAMP/PKA pathway.

American journal of physiology. Renal physiology 20060701

Hydrogen peroxide-mediated necrosis induction in HUVECs is associated with an atypical pattern of caspase-3 cleavage.

Experimental cell research 20060610

Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.

Gastroenterology 20060601

Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress.

Apoptosis : an international journal on programmed cell death 20060501

Ex vivo modulation of response to prednisolone in childhood acute lymphoblastic leukaemia.

British journal of haematology 20060501

The effects of tempol, 3-aminobenzamide and nitric oxide synthase inhibitors on acoustic injury of the mouse cochlea.

Hearing research 20060401

Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid.

American journal of physiology. Heart and circulatory physiology 20060401

IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase.

Biochemical and biophysical research communications 20060303

MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.

Diabetes 20060301

Inhibition of NOS-2 induction in LPS-stimulated J774.2 cells by 1, 5-isoquinolinediol, an inhibitor of PARP.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060301

The telomeric PARP, tankyrases, as targets for cancer therapy.

British journal of cancer 20060213

Beneficial effects of a novel ultrapotent poly(ADP-ribose) polymerase inhibitor in murine models of heart failure.

International journal of molecular medicine 20060201

Inhibition of poly(adp-ribose) polymerase reduces cardiomyocytic apoptosis after global cardiac arrest under cardiopulmonary bypass.

Shock (Augusta, Ga.) 20060201

Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study.

Acta neurobiologiae experimentalis 20060101

Poly(ADP-ribose) polymerase-1 inhibitor 3-aminobenzamide enhances apoptosis induction by platinum complexes in cisplatin-resistant tumor cells.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20060101

The inhibition and treatment of breast cancer with poly (ADP-ribose) polymerase (PARP-1) inhibitors.

International journal of biological sciences 20060101

Flow-cytometric assessment of cellular poly(ADP-ribosyl)ation capacity in peripheral blood lymphocytes.

Immunity & ageing : I & A 20060101

PARP-1 inhibitors: are they the long-sought genetically specific drugs for BRCA1/2-associated breast cancers?

International journal of medical sciences 20060101

Poly (ADP-ribose) polymerase (PARP) is essential for sulfur mustard-induced DNA damage repair, but has no role in DNA ligase activation.

Journal of applied toxicology : JAT 20060101

Inhibition of poly (ADP-ribose) polymerase as a protective effect of nicaraven in ionizing radiation- and ara-C-induced cell death.

Anticancer research 20060101

A weakened transcriptional enhancer yields variegated gene expression.

PloS one 20060101

Poly(ADP-ribose)polymerase activation mediates lung epithelial cell death in vitro but is not essential in hyperoxia-induced lung injury.

American journal of respiratory cell and molecular biology 20051201

Inhibition of poly (ADP-ribose) synthetase improves pulmonary arterial endothelium-dependent relaxation after ischemic-reperfusion injury of splanchnic artery in rats.

Anesthesia and analgesia 20051201

Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited.

Diabetes 20051201

Role of mitogen-activated protein kinases in hydrogen peroxide-induced cell death in osteoblastic cells.

Toxicology 20051105

Biodistribution and pharmacokinetics of the (19)F-labeled radiosensitizer 3-aminobenzamide: assessment by (19)F MR imaging.

Magnetic resonance imaging 20051101

Effect of 3-aminobenzamide, PARP inhibitor, on matrix metalloproteinase-9 level in plasma and brain of ischemic stroke model.

Toxicology 20051015

Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.

Laboratory investigation; a journal of technical methods and pathology 20051001

BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of Poly (ADP-Ribose) polymerase: an issue of potency.

Cancer biology & therapy 20050901

Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.

Journal of medicinal chemistry 20050811

Cigarette smoke extract induces DNA damage but not apoptosis in human bronchial epithelial cells.

American journal of respiratory cell and molecular biology 20050801

Cerebral endothelial cell apoptosis after ischemia-reperfusion: role of PARP activation and AIF translocation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050701

3-aminobenzamide prevents restraint-evoked immunocompromise.

Brain, behavior, and immunity 20050701

Absence of specific cell killing of the BRCA2-deficient human cancer cell line CAPAN1 by poly(ADP-ribose) polymerase inhibition.

Cancer biology & therapy 20050701

Poly (adp-ribose) synthetase inhibition reduces oxidative and nitrosative organ damage after thermal injury.

Pediatric surgery international 20050601

Effect of poly(ADP-ribosyl)ation inhibitors on the genotoxic effects of the boron neutron capture reaction.

Mutation research 20050502

Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and the development of bleomycin-induced lung injury.

The Journal of pharmacology and experimental therapeutics 20050501

Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.

Pharmacological research 20050501

Poly(ADP-ribose) polymerase-1 could facilitate the religation of topoisomerase I-linked DNA inhibited by camptothecin.

Cancer research 20050501

Cigarette smoke condensate induces MMP-12 gene expression in airway-like epithelia.

Biochemical and biophysical research communications 20050429

Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat.

Brain research 20050418

Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.

The FEBS journal 20050401

The role of poly (adenosine 5'-diphosphate-ribose) polymerase in the response of pituitary tumor cells to reactive oxygen species.

Endocrinology 20050301

Pathophysiological role of poly(ADP-ribose) polymerase (PARP) activation during acetaminophen-induced liver cell necrosis in mice.

Toxicological sciences : an official journal of the Society of Toxicology 20050301

Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene.

American journal of human genetics 20050301

Mechanism of ricin-induced apoptosis in human cervical cancer cells.

Biochemical pharmacology 20050301

Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration.

Shock (Augusta, Ga.) 20050301

Non A beta component of Alzheimer's disease amyloid and amyloid beta peptides evoked poly(ADP-ribose) polymerase-dependent release of apoptosis-inducing factor from rat brain mitochondria.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050301

Inhibitors of poly(ADP-ribose) polymerase modulate signal transduction pathways and secondary damage in experimental spinal cord trauma.

The Journal of pharmacology and experimental therapeutics 20050201

Disulfide bond mutagenesis and the structure and function of the head-to-tail macrocyclic trypsin inhibitor SFTI-1.

Biochemistry 20050201

Differentiative pathway activated by 3-aminobenzamide, an inhibitor of PARP, in human osteosarcoma MG-63 cells.

FEBS letters 20050131

Modulation of DNMT1 activity by ADP-ribose polymers.

Oncogene 20050106

FGF2-mediated upregulation of urokinase-type plasminogen activator expression requires a MAP-kinase dependent activation of poly(ADP-ribose) polymerase.

Journal of cellular physiology 20050101

Apoptosis inhibition plays a greater role than necrosis inhibition in decreasing bacterial translocation in experimental intestinal transplantation.

Surgery 20050101

Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte.

Arthritis research & therapy 20050101

Poly(ADP-ribosyl)ation and epigenetics. Is CTCF PARt of the plot?

Cell cycle (Georgetown, Tex.) 20050101

Negative correlation between poly-ADP-ribosylation of spleen cell histone proteins and initial duration of dimethylnitrosamine exposure to mice in vivo measured by Western blot immunoprobe assay: a possible biomarker for cancer detection.

Cancer detection and prevention 20050101

Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice.

Respiratory research 20050101

Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury.

Folia neuropathologica 20050101

MIBG, an inhibitor of arginine-dependent mono(ADP-ribosyl)ation, prevents differentiation of L6 skeletal myoblasts by inhibiting expression of myogenin and p21(cip1).

Experimental cell research 20041210

Inhibition of poly(ADP-ribose) polymerase prevents allergen-induced asthma-like reaction in sensitized Guinea pigs.

The Journal of pharmacology and experimental therapeutics 20041201

The role of poly(ADP-ribose) synthetase inhibition on the intestinal mucosal barrier after thermal injury.

Burns : journal of the International Society for Burn Injuries 20041201

5-Aminoisoquinolinone reduces colon injury by experimental colitis.

Naunyn-Schmiedeberg's archives of pharmacology 20041201

Effects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury.

Current eye research 20041201

Neuronal trauma model: in search of Thanatos.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20041101

Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.

Journal of medicinal chemistry 20041021

Colloidal gold particles as a new in vivo marker of early acute lung injury.

American journal of physiology. Lung cellular and molecular physiology 20041001

Poly(ADP-ribose) polymerase inhibition prevents homocysteine-induced endothelial dysfunction in the isolated rat aorta.

Pharmacology 20041001

Poly(ADP-ribosyl)ation regulates CTCF-dependent chromatin insulation.

Nature genetics 20041001

Caspase-1 and poly (ADP-ribose) polymerase inhibitors may protect against peroxynitrite-induced neurotoxicity independent of their enzyme inhibitor activity.

The European journal of neuroscience 20041001

Effects of inhibition of poly(adenosine diphosphate-ribose) synthase on acute cardiac allograft rejection.

Transplantation 20040915

Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia.

Life sciences 20040903

A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice.

The Journal of pharmacology and experimental therapeutics 20040901

The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.

The European journal of neuroscience 20040901

Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro.

Journal of neurotrauma 20040901

Effects 3-aminobenzamide on ultrastructure of hippocampal CA1 layer after global ischemia in gerbils.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901

Dual regulation of AP-2alpha transcriptional activation by poly(ADP-ribose) polymerase-1.

The Biochemical journal 20040815

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.

Science (New York, N.Y.) 20040813

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

Journal of medicinal chemistry 20040812

A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia.

The Journal of pharmacology and experimental therapeutics 20040801

Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: in vitro study of isolated rat heart model.

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040801

Pharmacological inhibition of DNA repair enzymes differentially modulates telomerase activity and apoptosis in two human leukaemia cell lines.

International journal of radiation biology 20040801

Role of PARP on iNOS pathway during endotoxin-induced acute lung injury.

Intensive care medicine 20040701

Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression.

International journal of molecular medicine 20040701

Inhibition of c-Jun N-terminal kinase decreases cardiomyocyte apoptosis and infarct size after myocardial ischemia and reperfusion in anaesthetized rats.

British journal of pharmacology 20040701

Differential DNA double strand break fixation dependence on poly(ADP-ribosylation) in L5178Y and CHO cells.

International journal of radiation biology 20040701

Long-term memory requires polyADP-ribosylation.

Science (New York, N.Y.) 20040618

Effect of DNA repair inhibitor (3-aminobenzamide) on genetic stability of loach (Misgurnus fossilis) embryos derived from cryopreserved sperm.

Theriogenology 20040601

Purification and properties of poly(ADP-ribose)polymerase from Crithidia fasciculata. Automodification and poly(ADP-ribosyl)ation of DNA topoisomerase I.

Molecular and biochemical parasitology 20040601

TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex.

Nature genetics 20040601

Dual role for poly(ADP-ribose)polymerase-1 and -2 and poly(ADP-ribose)glycohydrolase as DNA-repair and pro-apoptotic factors in rat germinal cells exposed to nitric oxide donors.

Biochimica et biophysica acta 20040528

Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.

Bioorganic & medicinal chemistry letters 20040517

Platelet-endothelial cell interaction in pulmonary micro-circulation: the role of PARS.

Thrombosis and haemostasis 20040401

Inhibition of poly(adenosine diphosphate-ribose) polymerase decreases long-term histologic damage in testicular ischemia-reperfusion injury.

Urology 20040401

Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy.

Diabetes 20040301

Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation.

Toxicology and applied pharmacology 20040301

Effect of poly(ADP-ribose) polymerase inhibitors on oxidative stress evoked hydroxyl radical level and macromolecules oxidation in cell free system of rat brain cortex.

Neuroscience letters 20040206

PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation.

International journal of radiation oncology, biology, physics 20040201

Modulation of ATP levels alters the mode of hydrogen peroxide-induced cell death in primary cortical cultures: effects of putative neuroprotective agents.

Brain research 20040130

The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).

Bioorganic & medicinal chemistry letters 20040105

Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.

Neurological research 20040101

Essential role for poly (ADP-ribosyl)ation in mouse preimplantation development.

BMC molecular biology 20040101

Mechanisms of suppression of neoplastic transformation in vitro by low doses of low LET radiation.

Carcinogenesis 20031201

The effect of 3-aminobenzamide, inhibitor of poly(ADP-ribose) polymerase, on human osteosarcoma cells.

International journal of oncology 20031201

Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species.

Free radical biology & medicine 20031201

3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice.

Experimental neurology 20031201

Cytosolic and endoplasmic reticulum Ca2+ concentrations determine the extent and the morphological type of apoptosis, respectively.

Annals of the New York Academy of Sciences 20031201

Hypoglycemic neuronal death and cognitive impairment are prevented by poly(ADP-ribose) polymerase inhibitors administered after hypoglycemia.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20031119

Role of poly(ADP-ribose) synthetase in pulmonary leukocyte recruitment.

American journal of physiology. Lung cellular and molecular physiology 20031101

Deleterious activation of poly(ADP-ribose)polymerase-1 in brain after in vivo oxidative stress.

Free radical research 20031101

Deleterious poly(ADP-ribose)polymerase-1 pathway activation in traumatic brain injury in rat.

Brain research 20031031

Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects.

European journal of medical research 20031022

Role of poly(ADP-ribose)polymerase in cisplatin-induced injury in LLC-PK1 cells.

Free radical biology & medicine 20031015

Integrin-mediated suppression of endotoxin-induced DNA damage in lung endothelial cells is sensitive to poly(ADP-ribose) polymerase-1 gene deletion.

International journal of molecular medicine 20031001

Cellular events involved in butyric acid-induced T cell apoptosis.

Journal of immunology (Baltimore, Md. : 1950) 20031001

Activation of poly(adenosine diphosphate-ribose) polymerase in mouse tumors treated by photodynamic therapy.

Photochemistry and photobiology 20031001

Recombinant IFN-alpha2b treatment activates poly (ADPR) polymerase-1 (PARP-1) in KB cancer cells.

European journal of cancer (Oxford, England : 1990) 20030901

The effect of PARS inhibition on ileal histopathology, apoptosis and lipid peroxidation in LPS-induced obstructive jaundice.

Pharmacological research 20030801

Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030801

The selection between apoptosis and necrosis is differentially regulated in hydrogen peroxide-treated and glutathione-depleted human promonocytic cells.

Cell death and differentiation 20030801

Involvement of poly(ADP-ribose) synthetase in acoustic trauma of the cochlea.

The Tohoku journal of experimental medicine 20030801

Possible role of nicaraven in neuroprotective effect on hippocampal slice culture.

Canadian journal of physiology and pharmacology 20030701

Hydrogen peroxide induces association between glyceraldehyde 3-phosphate dehydrogenase and phospholipase D2 to facilitate phospholipase D2 activation in PC12 cells.

Journal of neurochemistry 20030601

Hsp70 attenuates hypoxia/reoxygenation-induced activation of poly(ADP-ribose) synthetase in the nucleus of adult rat cardiomyocytes.

Molecular and cellular biochemistry 20030601

Inhibitors of poly (ADP-ribose) polymerase modulate signal transduction pathways in colitis.

European journal of pharmacology 20030523

Distribution of Poly(ADP-ribosyl)ation and cell death after cerebral ischemia in the neonatal rat.

Pediatric research 20030501

The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.

The Journal of urology 20030501

Apoptosis in leukemia cells is accompanied by alterations in the levels and localization of nucleolin.

The Journal of biological chemistry 20030307

Gene knockout or pharmacological inhibition of poly(ADP-ribose) polymerase-1 prevents lung inflammation in a murine model of asthma.

American journal of respiratory cell and molecular biology 20030301

Beneficial effects of poly (ADP-ribose) polymerase inhibition against the reperfusion injury in heart transplantation.

Free radical research 20030301

gamma-Irradiation-induced DNA damage enhances NO production via NF-kappaB activation in RAW264.7 cells.

Biochimica et biophysica acta 20030217

Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.

Critical care medicine 20030201

Poly(ADP-ribose) polymerase during reperfusion after transient forebrain ischemia: its role in brain edema and cell death.

Journal of molecular neuroscience : MN 20030201

Peroxynitrite-induced oligodendrocyte toxicity is not dependent on poly(ADP-ribose) polymerase activation.

Glia 20030115

Inhibition of telomerase increases resistance of melanoma cells to temozolomide, but not to temozolomide combined with poly (adp-ribose) polymerase inhibitor.

Molecular pharmacology 20030101

Nicotinamide- and caspase-mediated inhibition of poly(ADP-ribose) polymerase are associated with p53-independent cell cycle (G2) arrest and apoptosis.

Molecular and cellular biochemistry 20030101

Oxidant-induced cell death in renal epithelial cells: differential effects of inorganic and organic hydroperoxides.

Pharmacology & toxicology 20030101

Poly(ADP-ribose) polymerase (PARP-1) is not involved in DNA double-strand break recovery.

BMC cell biology 20030101

Effect of poly(ADP-ribose) polymerase inhibition on outer medullary hypoxic damage.

Nephron. Physiology 20030101

Inhibition of neuronal nitric oxide synthase-mediated activation of poly(ADP-ribose) polymerase in traumatic brain injury: neuroprotection by 3-aminobenzamide.

Neuroscience 20030101

Modulation of the activation of extracellular signal-regulated kinase (ERK) and the production of inflammatory mediators by ADP-ribosylation inhibitors.

Biological chemistry 20030101

Oxidative stress, cell death, and other damage to alveolar epithelial cells induced by cigarette smoke.

Tobacco induced diseases 20030101

Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.

Acta crystallographica. Section D, Biological crystallography 20021201

Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP.

Experimental lung research 20021201

Role of tight junction derangement in the endothelial dysfunction elicited by exogenous and endogenous peroxynitrite and poly(ADP-ribose) synthetase.

Shock (Augusta, Ga.) 20021101

The effect of H2O2 and tertiary butyl hydroperoxide upon a murine immortal lens epithelial cell line, alphaTN4-1.

Experimental eye research 20021101

Enhanced recovery of radiation-induced translocations from spermatogonial stem cells of p53 null mice.

Mutation research 20021031

Differential gene expression in gamma-irradiated BALB/3T3 fibroblasts under the influence of 3-aminobenzamide, an inhibitior of parp enzyme.

Mutation research 20021031

Poly(ADP-ribose) polymerase inhibitor increases growth inhibition and reduces G(2)/M cell accumulation induced by temozolomide in malignant glioma cells.

Glia 20021001

The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.

Pharmacology 20020901

Inhibition of poly(ADP-ribosyl)ation induces DNA hypermethylation: a possible molecular mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020801

The role of poly(ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis.

Pharmacological research 20020801

Nitric oxide induces caspase-dependent apoptosis and necrosis in neonatal rat cardiomyocytes.

Journal of molecular and cellular cardiology 20020801

Apoptosis inhibitors delay the cytopathic effect of bovine viral diarrhoea virus (BVDV).

Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20020801

Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.

Toxicology and applied pharmacology 20020715

Poly(ADP-ribose) polymerase inhibition prevents both apoptotic-like delayed neuronal death and necrosis after H(2)O(2) injury.

Journal of neurochemistry 20020701

tej defines a role for poly(ADP-ribosyl)ation in establishing period length of the arabidopsis circadian oscillator.

Developmental cell 20020701

Poly(Adp-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm.

Pharmacological research 20020701

The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells.

Archives of biochemistry and biophysics 20020615

Liposomal NAD(+) prevents diminished O(2) consumption by immunostimulated Caco-2 cells.

American journal of physiology. Lung cellular and molecular physiology 20020501

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Roles of oxidative stress and glutathione depletion in JP-8 jet fuel-induced apoptosis in rat lung epithelial cells.

Toxicology and applied pharmacology 20020415

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells.

Biochemical pharmacology 20020415

DNA ligase I null mouse cells show normal DNA repair activity but altered DNA replication and reduced genome stability.

Journal of cell science 20020401

Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition.

The Journal of biological chemistry 20020322

Protective effects of poly (ADP-ribose) synthase inhibitors on digoxin-induced cardiotoxicity in guinea-pig isolated hearts.

Pharmacological research 20020301

Apoptotic and genotoxic effects of a methyl sulfonate ester that selectively generates N3-methyladenine and poly(ADP-ribose) polymerase inhibitors in normal peripheral blood lymphocytes.

Cancer chemotherapy and pharmacology 20020301

[Modification of repair DNA synthesis in mutagen-treated human fibroblasts during adaptive response and the antimutagenic effect of garlic extract].

Genetika 20020301

[Comparison of the protective effect of garlic extract and cell defense during adaptive response].

Genetika 20020301

Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside.

Cell death and differentiation 20020201

X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance.

Cancer research 20020115

Sensitivity of HaCat keratinocytes to diabetogenic toxins.

Biochemical pharmacology 20020115

Increased frequency of DNA deletions in pink-eyed unstable mice carrying a mutation in the Werner syndrome gene homologue.

Carcinogenesis 20020101

Meningitis-associated central nervous system complications are mediated by the activation of poly(ADP-ribose) polymerase.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020101

Bench-to-bedside review: Cytopathic hypoxia.

Critical care (London, England) 20020101

Development of a high-throughput screening-amenable assay for human poly(ADP-ribose) polymerase inhibitors.

Journal of pharmacological and toxicological methods 20020101

Partial protection by poly(ADP-ribose) polymerase inhibitors from nitroxyl-induced cytotoxity in thymocytes.

Free radical biology & medicine 20011215

The sequence-specific DNA binding of NF-kappa B is reversibly regulated by the automodification reaction of poly (ADP-ribose) polymerase 1.

The Journal of biological chemistry 20011214

Impairment of the neuronal dopamine transporter activity in MPP(+)-treated rat was not prevented by treatments with nitric oxide synthase or poly(ADP-ribose) polymerase inhibitors.

Neuroscience letters 20011113

Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis.

The Journal of biological chemistry 20011012

Long-term neuroprotective effect of inhibiting poly(ADP-ribose) polymerase in rats with middle cerebral artery occlusion using a behavioral assessment.

Brain research 20011012

Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells.

Free radical biology & medicine 20011001

Different effects of tert-butylhydroperoxide-induced peroxynitrite-dependent and -independent DNA single-strand breakage on PC12 cell poly(ADP-ribose) polymerase activity.

European journal of biochemistry 20011001

TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.

The Journal of biological chemistry 20010921

Activation of poly(ADP-ribose) polymerase in severe hemorrhagic shock and resuscitation.

American journal of physiology. Gastrointestinal and liver physiology 20010801

Histone H3 phosphorylation is coupled to poly-(ADP-ribosylation) during reactive oxygen species-induced cell death in renal proximal tubular epithelial cells.

Molecular pharmacology 20010801

Suppression of poly (ADP-ribose) polymerase activation by 3-aminobenzamide in a rat model of myocardial infarction: long-term morphological and functional consequences.

British journal of pharmacology 20010801

Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture?

Shock (Augusta, Ga.) 20010801

Poly(adp-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge.

Shock (Augusta, Ga.) 20010801

Increased expression and activation of poly(ADP-ribose) polymerase (PARP) contribute to retinal ganglion cell death following rat optic nerve transection.

Cell death and differentiation 20010801

Cell density-dependent death mode switch of cultured cortical neurons under serum-free starvation stress.

Cellular and molecular neurobiology 20010801

Role of zinc in pulmonary endothelial cell response to oxidative stress.

American journal of physiology. Lung cellular and molecular physiology 20010701

Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.

Molecular and biochemical parasitology 20010701

Peroxynitrite production, DNA breakage, and poly(ADP-ribose) polymerase activation in a mouse model of oxazolone-induced contact hypersensitivity.

The Journal of investigative dermatology 20010701

Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.

Molecular pharmacology 20010601

3-Aminobenzamide, a poly (ADP-ribose) synthetase inhibitor, attenuates the acute inflammatory responses and brain injury in experimental Escherichia coli meningitis in the newborn piglet.

Neurological research 20010601

Myocardial ischemic preconditioning in rodents is dependent on poly (ADP-ribose) synthetase.

Molecular medicine (Cambridge, Mass.) 20010601

Regulation of the nuclear proteasome activity in myelomonocytic human leukemia cells after adriamycin treatment.

Blood 20010501

Suppression of the radiation-sensitive phenotype of hamster irs1 and irs2 strains selected for resistance to 3-aminobenzamide.

International journal of radiation biology 20010501

Effects of single or split exposure of leukemic cells to temozolomide, combined with poly(ADP-ribose) polymerase inhibitors on cell growth, chromosomal aberrations and base excision repair components.

Cancer chemotherapy and pharmacology 20010401

H2O2-induced cell death in human glioma cells: role of lipid peroxidation and PARP activation.

Neurochemical research 20010401

A role for poly(ADP-ribose) polymerase in the transcriptional regulation of the melanoma growth stimulatory activity (CXCL1) gene expression.

The Journal of biological chemistry 20010323

Role of cell cycle control in radiosensitization of mouse spermatogonial stem cells.

International journal of radiation biology 20010301

Rat germinal cells require PARP for repair of DNA damage induced by gamma-irradiation and H2O2 treatment.

European journal of cell biology 20010301

Poly(adenosine diphosphate-ribose) synthetase inhibitor 3-aminobenzamide alleviates cochlear dysfunction induced by transient ischemia.

The Annals of otology, rhinology, and laryngology 20010201

Regulation of BK(Ca) channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid.

Molecular pharmacology 20010101

Regulation of bleomycin-induced DNA breakage and chromatin structure in lung endothelial cells by integrins and poly(ADP-ribose) polymerase.

Molecular pharmacology 20010101

Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits.

Stroke 20010101

The role of nitric oxide in diaphragmatic dysfunction in endotoxemic rats.

Muscle & nerve 20010101

Excessive base excision repair of 5-hydroxymethyluracil from DNA induces apoptosis in Chinese hamster V79 cells containing mutant p53.

Carcinogenesis 20010101

Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20010101

[Neuronal death: potential role of the nuclear enzyme, poly (ADP-ribose) polymerase].

Bulletin de l'Academie nationale de medecine 20010101

Poly(ADP-ribose) polymerase-1 regulates the stability of the wild-type p53 protein.

Cellular & molecular biology letters 20010101

Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats.

American journal of physiology. Regulatory, integrative and comparative physiology 20001101

All trans retinoic acid induces apoptosis in acute promyelocytic NB4 cells when combined with isoquinolinediol, a poly(ADP-ribose) polymerase inhibitor.

Leukemia research 20000401

N-methyl-D-aspartate (NMDA)--induced apoptosis in rat retina.

Investigative ophthalmology & visual science 19990901

Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.

Journal of medicinal chemistry 19980423

Specific induction of the hsr omega locus of Drosophila melanogaster by amides.

Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology 19970901

Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.

Annals of tropical medicine and parasitology 19961201

Nitric oxide is a mediator of methamphetamine (METH)-induced neurotoxicity. In vitro evidence from primary cultures of mesencephalic cells.

Annals of the New York Academy of Sciences 19961031

Neuroprotection against nitric oxide injury with inhibitors of ADP-ribosylation.

Neuroreport 19931213

Effect of tumour promoters on poly ADP-ribosylation in human epidermoid carcinoma HeP2 cells.

International journal of experimental pathology 19901201

A comparative study on the effect of tumor promoters on poly ADP-ribosylation in A431 cells.

International journal of cancer 19901015

Enhancement of DEN initiation of liver carcinogenesis by inhibitors of NAD+ ADP ribosyl transferase in rats.

Carcinogenesis 19840701