Dl-sulforaphane
| Title | Journal |
|---|---|
| Stable cellular models of nuclear receptor PXR for high-throughput evaluation of small molecules. | Toxicology in vitro : an international journal published in association with BIBRA 20181001 |
| TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells. | Toxicology and applied pharmacology 20180801 |
| Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. | Archives of toxicology 20180401 |
| 4-Methylthio-3-butenyl isothiocyanate mediates nuclear factor (erythroid-derived 2)-like 2 activation by regulating reactive oxygen species production in human esophageal epithelial cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101 |
| Tussilagonone-induced Nrf2 pathway activation protects HepG2 cells from oxidative injury. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001 |
| Characterization of the Potent, Selective Nrf2 Activator, 3-(Pyridin-3-Ylsulfonyl)-5-(Trifluoromethyl)-2H-Chromen-2-One, in Cellular and In Vivo Models of Pulmonary Oxidative Stress. | The Journal of pharmacology and experimental therapeutics 20171001 |
| Nrf2 deficiency exacerbates ochratoxin A-induced toxicity in vitro and in vivo. | Toxicology 20170815 |
| Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway. | Environmental toxicology 20170801 |
| Sulforaphene enhances radiosensitivity of hepatocellular carcinoma through suppression of the NF-κB pathway. | Journal of biochemical and molecular toxicology 20170801 |
| Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease. | Environmental health perspectives 20170801 |
| Sulforaphane attenuates di-N-butylphthalate-induced reproductive damage in pubertal mice: Involvement of the Nrf2-antioxidant system. | Environmental toxicology 20170701 |
| In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. | Environmental health perspectives 20170401 |
| Ablation of Akt2 prevents paraquat-induced myocardial mitochondrial injury and contractile dysfunction: Role of Nrf2. | Toxicology letters 20170305 |
| Sulforaphane induces differential modulation of mitochondrial biogenesis and dynamics in normal cells and tumor cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170201 |
| Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. | Environmental toxicology 20170101 |
| Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells. | Chemico-biological interactions 20161225 |
| Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. | Toxicology and applied pharmacology 20160815 |
| Benzoquinone toxicity is not prevented by sulforaphane in CD-1 mouse fetal liver cells. | Journal of applied toxicology : JAT 20160801 |
| Iron depletion in HCT116 cells diminishes the upregulatory effect of phenethyl isothiocyanate on heme oxygenase-1. | Toxicology and applied pharmacology 20160415 |
| Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. | Acta pharmacologica Sinica 20160201 |
| Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1). | Toxicological sciences : an official journal of the Society of Toxicology 20160101 |
| Phytonutrients Differentially Stimulate NAD(P)H:Quinone Oxidoreductase, Inhibit Proliferation, and Trigger Mitotic Catastrophe in Hepa1c1c7 Cells. | Journal of medicinal food 20160101 |
| Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. | Nature communications 20160101 |
| Nrf2 activators as potential modulators of injury in human kidney cells. | Toxicology reports 20160101 |
| Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A. | Chemical research in toxicology 20151116 |
| Regulation of the expression of renal drug transporters in KEAP1-knockdown human tubular cells. | Toxicology in vitro : an international journal published in association with BIBRA 20150801 |
| Neuroprotective effect of sulforaphane against methylglyoxal cytotoxicity. | Chemical research in toxicology 20150615 |
| Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. | Journal of biochemical and molecular toxicology 20150601 |
| Sulforaphane protects against acetaminophen-induced hepatotoxicity. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20150601 |
| Resveratrol dimers, nutritional components in grape wine, are selective ROS scavengers and weak Nrf2 activators. | Food chemistry 20150415 |
| Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. | Toxicology and applied pharmacology 20150101 |
| Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon. | Clinical epigenetics 20150101 |
| Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo. | Antioxidants & redox signaling 20141120 |
| Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line. | Toxicology and applied pharmacology 20141115 |
| Modulation of cisplatin sensitivity in human ovarian carcinoma A2780 and SKOV3 cell lines by sulforaphane. | Toxicology letters 20141104 |
| The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: involvement of the Nrf2-ARE signaling pathway. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20141001 |
| Hepatic sulfotransferase as a nephropreventing target by suppression of the uremic toxin indoxyl sulfate accumulation in ischemic acute kidney injury. | Toxicological sciences : an official journal of the Society of Toxicology 20140901 |
| Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. | Toxicology and applied pharmacology 20140901 |
| Phytochemical modulators of mitochondria: the search for chemopreventive agents and supportive therapeutics. | Pharmaceuticals (Basel, Switzerland) 20140901 |
| Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. | Cell cycle (Georgetown, Tex.) 20140701 |
| The antioxidant effects of isorhamnetin contribute to inhibit COX-2 expression in response to inflammation: a potential role of HO-1. | Inflammation 20140601 |
| Intronic DNA elements regulate Nrf2 chemical responsiveness of the human microsomal epoxide hydrolase gene (EPHX1) through a far upstream alternative promoter. | Biochimica et biophysica acta 20140601 |
| Repeated Nrf2 stimulation using sulforaphane protects fibroblasts from ionizing radiation. | Toxicology and applied pharmacology 20140501 |
| Pau d'arco activates Nrf2-dependent gene expression via the MEK/ERK-pathway. | The Journal of toxicological sciences 20140401 |
| Discovery of potent Keap1-Nrf2 protein-protein interaction inhibitor based on molecular binding determinants analysis. | Journal of medicinal chemistry 20140327 |
| Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. | Chemical research in toxicology 20140317 |
| Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. | Free radical biology & medicine 20140201 |
| Sub-chronic sulforaphane exposure in CD-1 pregnant mice enhances maternal NADPH quinone oxidoreductase 1 (NQO1) activity and mRNA expression of NQO1, glutathione S-transferase, and glutamate-cysteine ligase: potential implications for fetal protection against toxicant exposure. | Reproductive toxicology (Elmsford, N.Y.) 20140101 |
| Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. | PloS one 20140101 |
| Sulforaphane attenuation of type 2 diabetes-induced aortic damage was associated with the upregulation of Nrf2 expression and function. | Oxidative medicine and cellular longevity 20140101 |
| Inhibition of Epstein-Barr virus reactivation in nasopharyngeal carcinoma cells by dietary sulforaphane. | Molecular carcinogenesis 20131201 |
| A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways. | Toxicology and applied pharmacology 20131101 |
| Calcineurin inhibitors recruit protein kinases JAK2 and JNK, TLR signaling and the UPR to activate NF-κB-mediated inflammatory responses in kidney tubular cells. | Toxicology and applied pharmacology 20131101 |
| Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells. | Pharmacological research 20131001 |
| The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells. | Toxicology and applied pharmacology 20130715 |
| Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro. | Toxicology and applied pharmacology 20130615 |
| Arsenic inhibits autophagic flux, activating the Nrf2-Keap1 pathway in a p62-dependent manner. | Molecular and cellular biology 20130601 |
| Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease. | Neurotoxicology 20130501 |
| Regulation of human carbonyl reductase 1 (CBR1, SDR21C1) gene by transcription factor Nrf2. | Chemico-biological interactions 20130225 |
| Role of Nrf2 antioxidant defense in mitigating cadmium-induced oxidative stress in the olfactory system of zebrafish. | Toxicology and applied pharmacology 20130115 |
| Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. | Antioxidants & redox signaling 20130110 |
| Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo. | Toxicology and applied pharmacology 20130101 |
| Sulforaphane as a potential protective phytochemical against neurodegenerative diseases. | Oxidative medicine and cellular longevity 20130101 |
| Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen. | International journal of oncology 20121201 |
| Interactions of sulforaphane and dimethyl sulfoxide with methyl methanesulfonate, urethane, 4-nitroquinoline-1-oxide and hydrogen peroxide in the Drosophila melanogaster wing spot test. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201 |
| Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. | International journal of food sciences and nutrition 20121101 |
| Sulforaphane inhibits restenosis by suppressing inflammation and the proliferation of vascular smooth muscle cells. | Atherosclerosis 20121101 |
| Sulforaphane synergistically enhances the cytotoxicity of arsenic trioxide in multiple myeloma cells via stress-mediated pathways. | Oncology reports 20121101 |
| Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion. | Molecular nutrition & food research 20121101 |
| Novel concepts of broccoli sulforaphanes and disease: induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli. | Nutrition reviews 20121101 |
| A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level. | The Journal of biological chemistry 20121019 |
| Sulphoraphane, a naturally occurring isothiocyanate induces apoptosis in breast cancer cells by targeting heat shock proteins. | Biochemical and biophysical research communications 20121012 |
| Sulforaphane induced adipolysis via hormone sensitive lipase activation, regulated by AMPK signaling pathway. | Biochemical and biophysical research communications 20121005 |
| The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor. | Archives of toxicology 20121001 |
| Activation of the stress proteome as a mechanism for small molecule therapeutics. | Human molecular genetics 20121001 |
| The Nrf2-antioxidant response element pathway: a target for regulating energy metabolism. | The Journal of nutritional biochemistry 20121001 |
| TrxR1 and GPx2 are potently induced by isothiocyanates and selenium, and mutually cooperate to protect Caco-2 cells against free radical-mediated cell death. | Biochimica et biophysica acta 20121001 |
| Pharmacokinetics and pharmacodynamics of phase II drug metabolizing/antioxidant enzymes gene response by anticancer agent sulforaphane in rat lymphocytes. | Molecular pharmaceutics 20121001 |
| Sulforaphane protects primary cultures of cortical neurons against injury induced by oxygen-glucose deprivation/reoxygenation via antiapoptosis. | Neuroscience bulletin 20121001 |
| Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2. | Biochemical pharmacology 20120915 |
| Natural sulforaphane as a functional chemopreventive agent: including a review of isolation, purification and analysis methods. | Critical reviews in biotechnology 20120901 |
| Naphthazarin has a protective effect on the 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine-induced Parkinson's disease model. | Journal of neuroscience research 20120901 |
| Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes. | Journal of biochemical and molecular toxicology 20120901 |
| Isothiocyanates ameliorate the symptom of heart dysfunction and mortality in a murine AIDS model by inhibiting apoptosis in the left ventricle. | Journal of medicinal food 20120901 |
| Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats. | Journal of medicinal food 20120901 |
| NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes. | Free radical biology & medicine 20120815 |
| Validation of the multiple sensor mechanism of the Keap1-Nrf2 system. | Free radical biology & medicine 20120815 |
| Nrf2-ARE pathway regulates induction of Sestrin-2 expression. | Free radical biology & medicine 20120815 |
| Quantitative profiling of glucosinolates by LC-MS analysis reveals several cultivars of cabbage and kale as promising sources of sulforaphane. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120815 |
| Characterization of products from the reaction of glucosinolate-derived isothiocyanates with cysteine and lysine derivatives formed in either model systems or broccoli sprouts. | Journal of agricultural and food chemistry 20120808 |
| Influence of broccoli extract and various essential oils on performance and expression of xenobiotic- and antioxidant enzymes in broiler chickens. | The British journal of nutrition 20120801 |
| Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. | Journal of gastroenterology 20120801 |
| Crosstalk between Nrf2 and the proteasome: therapeutic potential of Nrf2 inducers in vascular disease and aging. | The international journal of biochemistry & cell biology 20120801 |
| Sulforaphane, a cruciferous vegetable-derived isothiocyanate, inhibits protein synthesis in human prostate cancer cells. | Biochimica et biophysica acta 20120801 |
| Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120801 |
| Improvement in determination of isothiocyanates using high-temperature reversed-phase HPLC. | Journal of separation science 20120801 |
| Sulforaphane potentiates the efficacy of imatinib against chronic leukemia cancer stem cells through enhanced abrogation of Wnt/β-catenin function. | Journal of agricultural and food chemistry 20120718 |
| Protective effect of sulforaphane against oxidative stress: recent advances. | Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120701 |
| Protective effects of the antioxidant sulforaphane on behavioral changes and neurotoxicity in mice after the administration of methamphetamine. | Psychopharmacology 20120701 |
| Sulforaphane inhibits mitotic clonal expansion during adipogenesis through cell cycle arrest. | Obesity (Silver Spring, Md.) 20120701 |
| Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120701 |
| Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation. | Molecular medicine reports 20120701 |
| Effect of sulforaphane on growth inhibition in human brain malignant glioma GBM 8401 cells by means of mitochondrial- and MEK/ERK-mediated apoptosis pathway. | Cell biochemistry and biophysics 20120701 |
| Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress. | American journal of physiology. Regulatory, integrative and comparative physiology 20120701 |
| Cancer stem cells: potential target for bioactive food components. | The Journal of nutritional biochemistry 20120701 |
| Effects of sulforophane and curcumin on oxidative stress created by acute malathion toxicity in rats. | European review for medical and pharmacological sciences 20120701 |
| Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile. | Journal of agricultural and food chemistry 20120606 |
| Concurrent sulforaphane and eugenol induces differential effects on human cervical cancer cells. | Integrative cancer therapies 20120601 |
| Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures. | Neurochemistry international 20120601 |
| Toward an understanding of bisretinoid autofluorescence bleaching and recovery. | Investigative ophthalmology & visual science 20120601 |
| Glucosinolates and isothiocyanates in health and disease. | Trends in molecular medicine 20120601 |
| Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane. | Free radical biology & medicine 20120601 |
| Sulforaphane induction of p21(Cip1) cyclin-dependent kinase inhibitor expression requires p53 and Sp1 transcription factors and is p53-dependent. | The Journal of biological chemistry 20120511 |
| Sulforaphane, a natural constituent of broccoli, prevents cell death and inflammation in nephropathy. | The Journal of nutritional biochemistry 20120501 |
| Myrosinase hydrolysates of Brassica oleraceae L. var. italica reduce the risk of colon cancer. | Phytotherapy research : PTR 20120501 |
| Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods. | Ecotoxicology (London, England) 20120501 |
| In vivo biological activity of rocket extracts (Eruca vesicaria subsp. sativa (Miller) Thell) and sulforaphane. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501 |
| Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family. | Plant molecular biology 20120501 |
| Sulforaphane inhibits the Th2 immune response in ovalbumin-induced asthma. | BMB reports 20120501 |
| Sulforaphane retards the growth of UM-UC-3 xenographs, induces apoptosis, and reduces survivin in athymic mice. | Nutrition research (New York, N.Y.) 20120501 |
| [Antibacterial mechanism of sulforaphane on Escherichia coli]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501 |
| Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. | The Chinese journal of physiology 20120430 |
| Dose-dependent effects of R-sulforaphane isothiocyanate on the biology of human mesenchymal stem cells, at dietary amounts, it promotes cell proliferation and reduces senescence and apoptosis, while at anti-cancer drug doses, it has a cytotoxic effect. | Age (Dordrecht, Netherlands) 20120401 |
| Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(κ) B and microRNA-155. | Journal of cellular and molecular medicine 20120401 |
| Metabolism of [6]-shogaol in mice and in cancer cells. | Drug metabolism and disposition: the biological fate of chemicals 20120401 |
| Biotransformation of the antiretroviral drug etravirine: metabolite identification, reaction phenotyping, and characterization of autoinduction of cytochrome P450-dependent metabolism. | Drug metabolism and disposition: the biological fate of chemicals 20120401 |
| Antibacterial effects of glucosinolate-derived hydrolysis products against enterobacteriaceae and enterococci isolated from pig ileum segments. | Foodborne pathogens and disease 20120401 |
| Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. | The Journal of biological chemistry 20120323 |
| Loss of transcription factor nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) leads to dysregulation of immune functions, redox homeostasis, and intracellular signaling in dendritic cells. | The Journal of biological chemistry 20120323 |
| Activation of the nuclear factor E2-related factor 2/antioxidant response element pathway is neuroprotective after spinal cord injury. | Journal of neurotrauma 20120320 |
| PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress. | Biochemical and biophysical research communications 20120316 |
| Cell signalling by reactive lipid species: new concepts and molecular mechanisms. | The Biochemical journal 20120315 |
| Bioactive food components prevent carcinogenic stress via Nrf2 activation in BRCA1 deficient breast epithelial cells. | Toxicology letters 20120307 |
| Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells. | Journal of agricultural and food chemistry 20120307 |
| Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. | Cell metabolism 20120307 |
| Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply. | Carcinogenesis 20120301 |
| Metabolism of glucosinolate-derived isothiocyanates to glutathione conjugates in generalist lepidopteran herbivores. | Insect biochemistry and molecular biology 20120301 |
| Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner. | Molecular medicine reports 20120301 |
| Autophagy and cancer. | Experimental & molecular medicine 20120227 |
| A synthetic chalcone as a potent inducer of glutathione biosynthesis. | Journal of medicinal chemistry 20120209 |
| Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. | Breast cancer research and treatment 20120201 |
| Cyanidin does not affect sulforaphane-mediated Nrf2 induction in cultured human keratinocytes. | The British journal of nutrition 20120201 |
| D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc. | Journal of cellular biochemistry 20120201 |
| Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120201 |
| Nutritional influences on epigenetics and age-related disease. | The Proceedings of the Nutrition Society 20120201 |
| The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. | American journal of hypertension 20120201 |
| Screening for natural chemoprevention agents that modify human Keap1. | Analytical biochemistry 20120201 |
| Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice. | IUBMB life 20120201 |
| Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling. | Free radical biology & medicine 20120201 |
| Design, synthesis and biological evaluation of new naphtalene diimides bearing isothiocyanate functionality. | European journal of medicinal chemistry 20120201 |
| Protective effect of sulphoraphane against oxidative stress mediated toxicity induced by CuO nanoparticles in mouse embryonic fibroblasts BALB 3T3. | The Journal of toxicological sciences 20120201 |
| Epigenetic events associated with breast cancer and their prevention by dietary components targeting the epigenome. | Chemical research in toxicology 20120113 |
| Physiological and biochemical metabolism of germinating broccoli seeds and sprouts. | Journal of agricultural and food chemistry 20120111 |
| 6-Benzylaminopurine delays senescence and enhances health-promoting compounds of harvested broccoli. | Journal of agricultural and food chemistry 20120111 |
| Phytochemicals resveratrol and sulforaphane as potential agents for enhancing the anti-tumor activities of conventional cancer therapies. | Current pharmaceutical biotechnology 20120101 |
| Apoptosis Induction in Primary Human Colorectal Cancer Cell Lines and Retarded Tumor Growth in SCID Mice by Sulforaphane. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Tumor angiogenesis as a target for dietary cancer prevention. | Journal of oncology 20120101 |
| Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. | Carcinogenesis 20120101 |
| Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways. | Vascular pharmacology 20120101 |
| The role of nutraceuticals in chemoprevention and chemotherapy and their clinical outcomes. | Journal of oncology 20120101 |
| Analysis of tanshinone IIA induced cellular apoptosis in leukemia cells by genome-wide expression profiling. | BMC complementary and alternative medicine 20120101 |
| A new model for raf kinase inhibitory protein induced chemotherapeutic resistance. | PloS one 20120101 |
| Autophagy in pancreatic cancer. | International journal of cell biology 20120101 |
| Astroglial pentose phosphate pathway rates in response to high-glucose environments. | ASN neuro 20120101 |
| Comparison of three tocopherol analogs as an inhibitor of production of proinflammatory mediators in macrophages. | Journal of pharmacological sciences 20120101 |
| Induction of phase 2 antioxidant enzymes by broccoli sulforaphane: perspectives in maintaining the antioxidant activity of vitamins a, C, and e. | Frontiers in genetics 20120101 |
| Protein kinases and transcription factors activation in response to UV-radiation of skin: implications for carcinogenesis. | International journal of molecular sciences 20120101 |
| Procyanidins from wild grape (Vitis amurensis) seeds regulate ARE-mediated enzyme expression via Nrf2 coupled with p38 and PI3K/Akt pathway in HepG2 cells. | International journal of molecular sciences 20120101 |
| Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles. | International journal of nanomedicine 20120101 |
| L-cysteine administration attenuates pancreatic fibrosis induced by TNBS in rats by inhibiting the activation of pancreatic stellate cell. | PloS one 20120101 |
| Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum. | PloS one 20120101 |
| Cancer stem cells and novel targets for antitumor strategies. | Current pharmaceutical design 20120101 |
| Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts. | International journal of biological sciences 20120101 |
| Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts. | Cell communication and signaling : CCS 20120101 |
| Phytochemicals from plants to combat cardiovascular disease. | Current medicinal chemistry 20120101 |
| Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors. | Clinical epigenetics 20120101 |
| Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways. | PloS one 20120101 |
| Inhibition of intestinal adenoma formation in APC(Min/+) mice by Riccardin D, a natural product derived from liverwort plant Dumortiera hirsuta. | PloS one 20120101 |
| Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Chromium stress mitigation by polyamine-brassinosteroid application involves phytohormonal and physiological strategies in Raphanus sativus L. | PloS one 20120101 |
| Exposure to ozone modulates human airway protease/antiprotease balance contributing to increased influenza A infection. | PloS one 20120101 |
| The safety of cruciferous plants in humans: a systematic review. | Journal of biomedicine & biotechnology 20120101 |
| Glutathione homeostasis and functions: potential targets for medical interventions. | Journal of amino acids 20120101 |
| A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture. | PloS one 20120101 |
| Epigenetic factors in cancer risk: effect of chemical carcinogens on global DNA methylation pattern in human TK6 cells. | PloS one 20120101 |
| Platelet-rich plasma peptides: key for regeneration. | International journal of peptides 20120101 |
| The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes. | Mediators of inflammation 20120101 |
| Role of serine racemase in behavioral sensitization in mice after repeated administration of methamphetamine. | PloS one 20120101 |
| Sulforaphane potentiates RNA damage induced by different xenobiotics. | PloS one 20120101 |
| Mechanism of chemical activation of Nrf2. | PloS one 20120101 |
| Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment. | PloS one 20120101 |
| Epigenetics and breast cancers. | Obstetrics and gynecology international 20120101 |
| Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. | PloS one 20120101 |
| Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus. | PloS one 20120101 |
| Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells. | Journal of biomedicine & biotechnology 20120101 |
| Malabaricone-A induces a redox imbalance that mediates apoptosis in U937 cell line. | PloS one 20120101 |
| Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells. | PloS one 20120101 |
| Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention. | International journal of nanomedicine 20120101 |
| Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy. | Experimental diabetes research 20120101 |
| The yin and yang of nrf2-regulated selenoproteins in carcinogenesis. | International journal of cell biology 20120101 |
| Alternative strategy for Alzheimer's disease: stress response triggers. | International journal of Alzheimer's disease 20120101 |
| Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. | PloS one 20120101 |
| Dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5. | PloS one 20120101 |
| Anticancer activity of green tea polyphenols in prostate gland. | Oxidative medicine and cellular longevity 20120101 |
| Glycerol supplementation enhances L. reuteri's protective effect against S. Typhimurium colonization in a 3-D model of colonic epithelium. | PloS one 20120101 |
| Dietary polyphenols as modulators of brain functions: biological actions and molecular mechanisms underpinning their beneficial effects. | Oxidative medicine and cellular longevity 20120101 |
| Mechanisms of anticancer activity of sulforaphane from Brassica oleracea in HEp-2 human epithelial carcinoma cell line. | Asian Pacific journal of cancer prevention : APJCP 20120101 |
| Photothrombosis-induced infarction of the mouse cerebral cortex is not affected by the Nrf2-activator sulforaphane. | PloS one 20120101 |
| Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer. | Journal of carcinogenesis 20120101 |
| Sonic hedgehog signaling inhibition provides opportunities for targeted therapy by sulforaphane in regulating pancreatic cancer stem cell self-renewal. | PloS one 20120101 |
| Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation. | Oxidative medicine and cellular longevity 20120101 |
| Activating Nrf-2 signaling depresses unilateral ureteral obstruction-evoked mitochondrial stress-related autophagy, apoptosis and pyroptosis in kidney. | PloS one 20120101 |
| Lipids, blood pressure, kidney - what was new in 2011? | Archives of medical science : AMS 20111231 |
| Sulforaphane inhibits mitochondrial permeability transition and oxidative stress. | Free radical biology & medicine 20111215 |
| Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells. | Toxicology and applied pharmacology 20111215 |
| Transthiocarbamoylation of proteins by thiolated isothiocyanates. | The Journal of biological chemistry 20111209 |
| Cancer chemoprevention by targeting the epigenome. | Current drug targets 20111201 |
| Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice. | Pharmaceutical research 20111201 |
| Novel insights into the regulation of antioxidant-response-element-mediated gene expression by electrophiles: induction of the transcriptional repressor BACH1 by Nrf2. | The Biochemical journal 20111201 |
| Health benefits and possible risks of broccoli - an overview. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201 |
| Nutritional antioxidants and adaptive cell responses: an update. | Current molecular medicine 20111201 |
| GSTT1 is upregulated by oxidative stress through p38-MK2 signaling pathway in human granulosa cells: possible association with mitochondrial activity. | Aging 20111201 |
| Toxicological aspects of the use of phenolic compounds in disease prevention. | Interdisciplinary toxicology 20111201 |
| An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells. | Marine drugs 20111201 |
| Induction of glutathione synthesis and conjugation by 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-dihydroxymethamphetamine (HHMA) in human and rat liver cells, including the protective role of some antioxidants. | Toxicology 20111118 |
| Sulforaphane inhibits oral carcinoma cell migration and invasion in vitro. | Phytotherapy research : PTR 20111101 |
| Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells. | Neurochemical research 20111101 |
| Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells. | Molecular pharmacology 20111101 |
| Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design. | Pharmacological research 20111101 |
| Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells. | Free radical biology & medicine 20111101 |
| Glucoraphanin does not reduce plasma homocysteine in rats with sufficient Se supply via the induction of liver ARE-regulated glutathione biosynthesis enzymes. | Food & function 20111101 |
| Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. | The Journal of clinical investigation 20111101 |
| Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. | Current neurovascular research 20111101 |
| Nrf2 activators as attractive therapeutics for diabetic nephropathy. | Diabetes 20111101 |
| Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy. | Diabetes 20111101 |
| Sulforaphane induces antioxidative and antiproliferative responses by generating reactive oxygen species in human bronchial epithelial BEAS-2B cells. | Journal of Korean medical science 20111101 |
| Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement. | Journal of agricultural and food chemistry 20111026 |
| Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells. | Clinical epigenetics 20111026 |
| Identification of potential protein targets of isothiocyanates by proteomics. | Chemical research in toxicology 20111017 |
| Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. | Antioxidants & redox signaling 20111015 |
| Transforming growth factor-β and nuclear factor E2–related factor 2 regulate antioxidant responses in airway smooth muscle cells: role in asthma. | American journal of respiratory and critical care medicine 20111015 |
| Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53. | Toxicology in vitro : an international journal published in association with BIBRA 20111001 |
| Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin. | Molecular nutrition & food research 20111001 |
| Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway. | Biochimica et biophysica acta 20111001 |
| Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle. | Gastroenterology 20111001 |
| Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway. | Cancer prevention research (Philadelphia, Pa.) 20111001 |
| Novel function of transcription factor Nrf2 as an inhibitor of RON tyrosine kinase receptor-mediated cancer cell invasion. | The Journal of biological chemistry 20110916 |
| Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. | The Journal of nutritional biochemistry 20110901 |
| Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice. | Oncology reports 20110901 |
| Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease. | Disease models & mechanisms 20110901 |
| Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway. | Toxicology and applied pharmacology 20110901 |
| Transcription factor Nrf2 protects the spinal cord from inflammation produced by spinal cord injury. | The Journal of surgical research 20110901 |
| Radiosensitization of head and neck cancer cells by the phytochemical agent sulforaphane. | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20110901 |
| Pharmaconutrition for the obese, critically ill patient. | JPEN. Journal of parenteral and enteral nutrition 20110901 |
| Nrf2, a PPARγ alternative pathway to promote CD36 expression on inflammatory macrophages: implication for malaria. | PLoS pathogens 20110901 |
| Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway. | Journal of food science 20110901 |
| Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats. | Toxicology 20110815 |
| Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice. | Toxicology and applied pharmacology 20110815 |
| LC-MS/MS quantification of sulforaphane and indole-3-carbinol metabolites in human plasma and urine after dietary intake of selenium-fortified broccoli. | Journal of agricultural and food chemistry 20110810 |
| Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality. | Archives of toxicology 20110801 |
| Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury. | Environmental health perspectives 20110801 |
| The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes. | Pharmaceutical research 20110801 |
| 3,3'-Diindolylmethane but not indole-3-carbinol activates Nrf2 and induces Nrf2 target gene expression in cultured murine fibroblasts. | Free radical research 20110801 |
| Nrf-2 regulates cyclosporine-stimulated HO-1 expression in gingiva. | Journal of dental research 20110801 |
| Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma. | Haematologica 20110801 |
| Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells. | Free radical biology & medicine 20110715 |
| Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells. | Molecular nutrition & food research 20110701 |
| Sulforaphane protects human chondrocytes against cell death induced by various stimuli. | Journal of cellular physiology 20110701 |
| Autophagy and cell death signaling following dietary sulforaphane act independently of each other and require oxidative stress in pancreatic cancer. | International journal of oncology 20110701 |
| Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20110701 |
| Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. | Drug and chemical toxicology 20110701 |
| Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. | Biopharmaceutics & drug disposition 20110701 |
| Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications. | Annals of the New York Academy of Sciences 20110701 |
| The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics. | Chemico-biological interactions 20110630 |
| Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. | Journal of medicinal chemistry 20110623 |
| The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer. | International journal of cancer 20110615 |
| Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism. | Antioxidants & redox signaling 20110615 |
| Anti-carcinogenic effects of sulforaphane in association with its apoptosis-inducing and anti-inflammatory properties in human cervical cancer cells. | Cancer epidemiology 20110601 |
| Sulforaphane inhibits de novo synthesis of IL-8 and MCP-1 in human epithelial cells generated by cigarette smoke extract. | Journal of immunotoxicology 20110601 |
| Impact of Nrf2 on UVB-induced skin inflammation/photoprotection and photoprotective effect of sulforaphane. | Molecular carcinogenesis 20110601 |
| Inhibition of pattern recognition receptor-mediated inflammation by bioactive phytochemicals. | Nutrition reviews 20110601 |
| Phytochemical analysis and antimicrobial activity of Cardaria draba (L.) Desv. volatiles. | Chemistry & biodiversity 20110601 |
| Epigallocatechin-3-gallate Regulates Inducible Nitric Oxide Synthase Expression in Human Umbilical Vein Endothelial Cells. | Laboratory animal research 20110601 |
| Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29. | Chemico-biological interactions 20110530 |
| 3,4-methylenedioxymethamphetamine (MDMA) interacts with therapeutic drugs on CYP3A by inhibition of pregnane X receptor (PXR) activation and catalytic enzyme inhibition. | Toxicology letters 20110530 |
| Disulfiram modulated ROS-MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties. | British journal of cancer 20110510 |
| Sulforaphane potentiates oxaliplatin-induced cell growth inhibition in colorectal cancer cells via induction of different modes of cell death. | Cancer chemotherapy and pharmacology 20110501 |
| Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex. | Toxicological sciences : an official journal of the Society of Toxicology 20110501 |
| Intrinsic and extrinsic regulation of innate immune receptors. | Yonsei medical journal 20110501 |
| Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. | Drug metabolism reviews 20110501 |
| Modification of keap1 cysteine residues by sulforaphane. | Chemical research in toxicology 20110418 |
| Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells. | Free radical biology & medicine 20110415 |
| Targeting Nrf2 signaling improves bacterial clearance by alveolar macrophages in patients with COPD and in a mouse model. | Science translational medicine 20110413 |
| Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity. | Phytotherapy research : PTR 20110401 |
| Role of the Nrf2-ARE pathway in early brain injury after experimental subarachnoid hemorrhage. | Journal of neuroscience research 20110401 |
| Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages. | Archives of biochemistry and biophysics 20110401 |
| Phenethyl isothiocyanate exhibits antileukemic activity in vitro and in vivo by inactivation of Akt and activation of JNK pathways. | Cell death & disease 20110401 |
| [Inhibition of glucoraphenin enzymolysis in Raphani Semen by processing]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110401 |
| Food: The omnivore's labyrinth. | Nature 20110324 |
| Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress. | Biochemical and biophysical research communications 20110311 |
| Pseudomonas sax genes overcome aliphatic isothiocyanate-mediated non-host resistance in Arabidopsis. | Science (New York, N.Y.) 20110304 |
| Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin. | Lung cancer (Amsterdam, Netherlands) 20110301 |
| Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. | Cancer prevention research (Philadelphia, Pa.) 20110301 |
| Heme oxygenase-1: a novel therapeutic target for gastrointestinal diseases. | Journal of clinical biochemistry and nutrition 20110301 |
| Omega-3 fatty acid oxidation products prevent vascular endothelial cell activation by coplanar polychlorinated biphenyls. | Toxicology and applied pharmacology 20110215 |
| Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships. | Journal of medicinal chemistry 20110210 |
| Stimulation of phagocytosis by sulforaphane. | Biochemical and biophysical research communications 20110204 |
| Protective role of sulforaphane against oxidative stress mediated mitochondrial dysfunction induced by benzo(a)pyrene in female Swiss albino mice. | Pulmonary pharmacology & therapeutics 20110201 |
| Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells. | Carcinogenesis 20110201 |
| Role of sulforaphane in the anti-initiating mechanism of lung carcinogenesis in vivo by modulating the metabolic activation and detoxification of benzo(a)pyrene. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110201 |
| Human CYP2A6 is regulated by nuclear factor-erythroid 2 related factor 2. | Biochemical pharmacology 20110115 |
| Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. | Molecular therapy : the journal of the American Society of Gene Therapy 20110104 |
| Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytes. | Environmental health perspectives 20110101 |
| Involvement of caspase-9 in autophagy-mediated cell survival pathway. | Biochimica et biophysica acta 20110101 |
| Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage. | Neuropharmacology 20110101 |
| Dietary phenethyl isothiocyanate alters gene expression in human breast cancer cells. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Bioactive food components and cancer-specific metabonomic profiles. | Journal of biomedicine & biotechnology 20110101 |
| Sulforaphane synergizes with quercetin to inhibit self-renewal capacity of pancreatic cancer stem cells. | Frontiers in bioscience (Elite edition) 20110101 |
| Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents. | BMC genomics 20110101 |
| Sulforaphane absorption and excretion following ingestion of a semi-purified broccoli powder rich in glucoraphanin and broccoli sprouts in healthy men. | Nutrition and cancer 20110101 |
| Molecular basis for vulnerability to mitochondrial and oxidative stress in a neuroendocrine CRI-G1 cell line. | PloS one 20110101 |
| Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes - Incorporation of cellular antioxidant response and threshold-dependent behavior. | BMC systems biology 20110101 |
| Prolonged sulforaphane treatment activates survival signaling in nontumorigenic NCM460 colon cells but apoptotic signaling in tumorigenic HCT116 colon cells. | Nutrition and cancer 20110101 |
| Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner. | Nutrition journal 20110101 |
| Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity. | Nutrition and cancer 20110101 |
| Resveratrol inhibits pancreatic cancer stem cell characteristics in human and KrasG12D transgenic mice by inhibiting pluripotency maintaining factors and epithelial-mesenchymal transition. | PloS one 20110101 |
| The endotoxin-induced neuroinflammation model of Parkinson's disease. | Parkinson's disease 20110101 |
| Glutathione biosynthesis via activation of the nuclear factor E2-related factor 2 (Nrf2)--antioxidant-response element (ARE) pathway is essential for neuroprotective effects of sulforaphane and 6-(methylsulfinyl) hexyl isothiocyanate. | Journal of pharmacological sciences 20110101 |
| The Nrf2/ARE Pathway: A Promising Target to Counteract Mitochondrial Dysfunction in Parkinson's Disease. | Parkinson's disease 20110101 |
| Discovery of molecular mechanisms of traditional Chinese medicinal formula Si-Wu-Tang using gene expression microarray and connectivity map. | PloS one 20110101 |
| Sulforaphane blocks hypoxia-mediated resistance to TRAIL-induced tumor cell death. | Molecular medicine reports 20110101 |
| Drosophila models of Parkinson's disease: discovering relevant pathways and novel therapeutic strategies. | Parkinson's disease 20110101 |
| Chemopreventive role of sulforaphane by upholding the GSH redox cycle in pre- and post-initiation phases of experimental lung carcinogenesis. | Asian Pacific journal of cancer prevention : APJCP 20110101 |
| Stroma regulates increased epithelial lateral cell adhesion in 3D culture: a role for actin/cadherin dynamics. | PloS one 20110101 |
| Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. | PloS one 20110101 |
| Sulforaphane enhances protection and repair of gastric mucosa against oxidative stress in vitro, and demonstrates anti-inflammatory effects on Helicobacter pylori-infected gastric mucosae in mice and human subjects. | Current pharmaceutical design 20110101 |
| NNK-Induced Lung Tumors: A Review of Animal Model. | Journal of oncology 20110101 |
| Age-related retinopathy in NRF2-deficient mice. | PloS one 20110101 |
| Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly. | Molecular cancer 20110101 |
| Targeting Glycogen Synthase Kinase-3β for Therapeutic Benefit against Oxidative Stress in Alzheimer's Disease: Involvement of the Nrf2-ARE Pathway. | International journal of Alzheimer's disease 20110101 |
| Of cabbages and kings. | Gut microbes 20110101 |
| Combination treatment with 5-fluorouracil and isothiocyanates shows an antagonistic effect in Chinese hamster fibroblast cells line-V79. | Acta poloniae pharmaceutica 20110101 |
| The role of blood flow in determining the sites of atherosclerotic plaques. | F1000 medicine reports 20110101 |
| Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay. | PloS one 20110101 |
| Separation and purification of sulforaphane from broccoli by solid phase extraction. | International journal of molecular sciences 20110101 |
| Stromal upregulation of lateral epithelial adhesions: gene expression analysis of signalling pathways in prostate epithelium. | Journal of biomedical science 20110101 |
| Induction of G₂/M arrest and apoptosis by sulforaphane in human osteosarcoma U2-OS cells. | Molecular medicine reports 20110101 |
| Inhibition of premature death by isothiocyanates through immune restoration in LP-BM5 leukemia retrovirus-infected C57BL/6 mice. | Bioscience, biotechnology, and biochemistry 20110101 |
| NRF2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic Parkinson's disease. | PloS one 20110101 |
| Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system. | Respiratory research 20110101 |
| Identification of NF-κB modulation capabilities within human intestinal commensal bacteria. | Journal of biomedicine & biotechnology 20110101 |
| Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors. | Journal of biomedicine & biotechnology 20110101 |
| Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms. | PloS one 20110101 |
| Inhibition of lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression by 4-[(2'-O-acetyl-α-L-rhamnosyloxy)benzyl]isothiocyanate from Moringa oleifera. | Nutrition and cancer 20110101 |
| Benzyl isothiocyanate, a major component from the roots of Salvadora persica is highly active against Gram-negative bacteria. | PloS one 20110101 |
| Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols. | Molecular vision 20110101 |
| Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. | PloS one 20110101 |
| Sulforaphane potentiates the efficacy of 17-allylamino 17-demethoxygeldanamycin against pancreatic cancer through enhanced abrogation of Hsp90 chaperone function. | Nutrition and cancer 20110101 |
| Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study. | Journal of clinical bioinformatics 20110101 |
| Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning. | Oxidative medicine and cellular longevity 20110101 |
| Resveratrol inhibits growth of orthotopic pancreatic tumors through activation of FOXO transcription factors. | PloS one 20110101 |
| Antimelanogenic effect of c-phycocyanin through modulation of tyrosinase expression by upregulation of ERK and downregulation of p38 MAPK signaling pathways. | Journal of biomedical science 20110101 |
| Evidence for oxidative stress and defective antioxidant response in guinea pigs with tuberculosis. | PloS one 20110101 |
| Galectin-3 and Beclin1/Atg6 genes in human cancers: using cDNA tissue panel, qRT-PCR, and logistic regression model to identify cancer cell biomarkers. | PloS one 20110101 |
| Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice. | PloS one 20110101 |
| Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration. | PloS one 20110101 |
| Tissue-restricted expression of Nrf2 and its target genes in zebrafish with gene-specific variations in the induction profiles. | PloS one 20110101 |
| Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferation. | Journal of experimental therapeutics & oncology 20110101 |
| Butyrate enhances disease resistance of chickens by inducing antimicrobial host defense peptide gene expression. | PloS one 20110101 |
| A switch from canonical to noncanonical Wnt signaling mediates drug resistance in colon cancer cells. | PloS one 20110101 |
| Development and validation of an LC-MS-MS method for the simultaneous determination of sulforaphane and its metabolites in rat plasma and its application in pharmacokinetic studies. | Journal of chromatographic science 20110101 |
| Low intracellular ATP levels exacerbate carcinogen-induced inflammatory stress response and inhibit in vitro tubulogenesis in human brain endothelial cells. | Journal of inflammation research 20110101 |
| New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer. | Prostate cancer 20110101 |
| Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy. | Scoliosis 20110101 |
| Effect of Turkish propolis extracts on proteome of prostate cancer cell line. | Proteome science 20110101 |
| MRI to assess chemoprevention in transgenic adenocarcinoma of mouse prostate (TRAMP). | BMC medical imaging 20110101 |
| Mechanisms of Action Involved in Ozone Therapy: Is healing induced via a mild oxidative stress? | Medical gas research 20110101 |
| Strategies for reducing or preventing the generation of oxidative stress. | Oxidative medicine and cellular longevity 20110101 |
| Chinese herb mix Tiáo-Gēng-Tāng possesses antiaging and antioxidative effects and upregulates expression of estrogen receptors alpha and beta in ovariectomized rats. | BMC complementary and alternative medicine 20110101 |
| The Nrf1 CNC-bZIP protein is regulated by the proteasome and activated by hypoxia. | PloS one 20110101 |
| Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells. | Clinical epigenetics 20110101 |
| Compositional studies: antioxidant and antidiabetic activities of Capparis decidua (Forsk.) Edgew. | International journal of molecular sciences 20110101 |
| Epigenomics of ovarian cancer and its chemoprevention. | Frontiers in genetics 20110101 |
| Epigenetic Contributions to the Relationship between Cancer and Dietary Intake of Nutrients, Bioactive Food Components, and Environmental Toxicants. | Frontiers in genetics 20110101 |
| Potential chemopreventive agents based on the structure of the lead compound 2-bromo-1-hydroxyphenazine, isolated from Streptomyces species, strain CNS284. | Journal of medicinal chemistry 20101223 |
| Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica. | Evidence-based complementary and alternative medicine : eCAM 20101201 |
| The Chinese herbal medicine Sophora flavescens activates pregnane X receptor. | Drug metabolism and disposition: the biological fate of chemicals 20101201 |
| Sulforaphane modulates the expression of Cyp6a2 and Cyp6g1 in larvae of the ST and HB crosses of the Drosophila wing spot test and is genotoxic in the ST cross. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101201 |
| Organosulfur compounds and cardiovascular disease. | Molecular aspects of medicine 20101201 |
| Determination of new biomarkers to monitor the dietary consumption of isothiocyanates. | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20101201 |
| Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition. | Journal of bioenergetics and biomembranes 20101201 |
| Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy. | Translational oncology 20101201 |
| [Sulforaphane--a possible agent in prevention and therapy of cancer]. | Postepy higieny i medycyny doswiadczalnej (Online) 20101129 |
| Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27. | The Journal of biological chemistry 20101112 |
| Protective effect of sulforaphane against cisplatin-induced mitochondrial alterations and impairment in the activity of NAD(P)H: quinone oxidoreductase 1 and γ glutamyl cysteine ligase: studies in mitochondria isolated from rat kidney and in LLC-PK1 cells. | Toxicology letters 20101110 |
| Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables. | Toxicology 20101109 |
| Polymorphisms in GSTT1, GSTZ1, and CYP2E1, disinfection by-products, and risk of bladder cancer in Spain. | Environmental health perspectives 20101101 |
| Sulforaphane inhibits endothelial lipase expression through NF-κB in endothelial cells. | Atherosclerosis 20101101 |
| Sulforaphane inhibits 4-aminobiphenyl-induced DNA damage in bladder cells and tissues. | Carcinogenesis 20101101 |
| Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. | Biological chemistry 20101101 |
| The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice. | Acta pharmacologica Sinica 20101101 |
| Sulforaphane suppresses TARC/CCL17 and MDC/CCL22 expression through heme oxygenase-1 and NF-κB in human keratinocytes. | Archives of pharmacal research 20101101 |
| Glucoraphanin hydrolysis by microbiota in the rat cecum results in sulforaphane absorption. | Food & function 20101101 |
| A cautionary note on using N-acetylcysteine as an antagonist to assess isothiocyanate-induced reactive oxygen species-mediated apoptosis. | Analytical biochemistry 20101015 |
| Regulation of human carbonyl reductase 3 (CBR3; SDR21C2) expression by Nrf2 in cultured cancer cells. | Biochemistry 20101005 |
| Isothiocyanate sulforaphane inhibits protooncogenic ornithine decarboxylase activity in colorectal cancer cells via induction of the TGF-β/Smad signaling pathway. | Molecular nutrition & food research 20101001 |
| Sulforaphane decreases viability and telomerase activity in hepatocellular carcinoma Hep3B cells through the reactive oxygen species-dependent pathway. | Cancer letters 20100928 |
| Heteroaromatic 4-arylquinols are novel inducers of nuclear factor-erythroid 2-related factor 2 (Nrf2). | European journal of pharmacology 20100925 |
| Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell. | Neuroscience 20100915 |
| Modular, homochiral, porous coordination polymers: rational design, enantioselective guest exchange sorption and ab initio calculations of host-guest interactions. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100910 |
| Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20100901 |
| Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response. | Toxicology and applied pharmacology 20100901 |
| Hexane extract of Raphanus sativus L. roots inhibits cell proliferation and induces apoptosis in human cancer cells by modulating genes related to apoptotic pathway. | Plant foods for human nutrition (Dordrecht, Netherlands) 20100901 |
| Dietary polyphenol quercetin targets pancreatic cancer stem cells. | International journal of oncology 20100901 |
| The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis. | Angiogenesis 20100901 |
| Regulation of Nrf2- and AP-1-mediated gene expression by epigallocatechin-3-gallate and sulforaphane in prostate of Nrf2-knockout or C57BL/6J mice and PC-3 AP-1 human prostate cancer cells. | Acta pharmacologica Sinica 20100901 |
| Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. | Cancer metastasis reviews 20100901 |
| Autophagy inhibition enhances sulforaphane-induced apoptosis in human breast cancer cells. | Anticancer research 20100901 |
| Comparison of the apoptosis-inducing capability of sulforaphane analogues in human colon cancer cells. | Anticancer research 20100901 |
| Independent effects of the broccoli-derived compound sulforaphane on Ca²⁺ influx and apoptosis in Madin-Darby canine renal tubular cells. | The Chinese journal of physiology 20100831 |
| Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates. | Chemical research in toxicology 20100816 |
| Sulforaphane suppresses ultraviolet B-induced inflammation in HaCaT keratinocytes and HR-1 hairless mice. | The Journal of nutritional biochemistry 20100801 |
| Sulforaphane- and phenethyl isothiocyanate-induced inhibition of aflatoxin B1-mediated genotoxicity in human hepatocytes: role of GSTM1 genotype and CYP3A4 gene expression. | Toxicological sciences : an official journal of the Society of Toxicology 20100801 |
| Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells. | The Journal of nutrition 20100801 |
| Induction of detoxification enzymes by feeding unblanched Brussels sprouts containing active myrosinase to mice for 2 wk. | Journal of food science 20100801 |
| Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme. | Brain research 20100709 |
| Sulforaphane induces DNA single strand breaks in cultured human cells. | Mutation research 20100707 |
| Does molecular docking reveal alternative chemopreventive mechanism of activation of oxidoreductase by sulforaphane isothiocyanates? | Journal of molecular modeling 20100701 |
| Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: synthesis, evaluation and SAR. | European journal of medicinal chemistry 20100701 |
| Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway. | World journal of gastroenterology 20100628 |
| Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver. | Journal of proteomics 20100616 |
| Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics. | Cancer research 20100615 |
| Analysis and anti-Helicobacter activity of sulforaphane and related compounds present in broccoli ( Brassica oleracea L.) sprouts. | Journal of agricultural and food chemistry 20100609 |
| Sulforaphane suppresses LPS-induced inflammation in primary rat microglia. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100601 |
| Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress. | Environmental health perspectives 20100601 |
| The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. | Toxicological sciences : an official journal of the Society of Toxicology 20100601 |
| Regulation of neutrophil elastase-induced MUC5AC expression by nuclear factor erythroid-2 related factor 2 in human airway epithelial cells. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20100601 |
| Protective effect of sulforaphane on human vascular endothelial cells against lipopolysaccharide-induced inflammatory damage. | Cardiovascular toxicology 20100601 |
| Cancer prevention with natural compounds. | Seminars in oncology 20100601 |
| Inactivation of Aconitase by Tetrahydrobiopterin in DArgic Cells: Relevance to PD. | Experimental neurobiology 20100601 |
| Electrophilic tuning of the chemoprotective natural product sulforaphane. | Proceedings of the National Academy of Sciences of the United States of America 20100525 |
| Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: modulation by the Nrf2/Trx axis. | Free radical biology & medicine 20100515 |
| Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation. | Journal of neuroscience research 20100501 |
| Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation. | The Journal of nutrition 20100501 |
| A complex interplay of three R2R3 MYB transcription factors determines the profile of aliphatic glucosinolates in Arabidopsis. | Plant physiology 20100501 |
| Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20100501 |
| Antitumor activity and COMPARE analysis of bis-indole derivatives. | Bioorganic & medicinal chemistry 20100501 |
| Identification and characterization of novel Nrf2 inducers designed to target the intervening region of Keap1. | Chemical biology & drug design 20100501 |
| When food meets man: the contribution of epigenetics to health. | Nutrients 20100501 |
| New biomarkers for monitoring the levels of isothiocyanates in humans. | Chemical research in toxicology 20100419 |
| The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. | Free radical biology & medicine 20100415 |
| Enhanced Nrf2-dependent induction of glutathione in mouse embryonic fibroblasts by isoselenocyanate analog of sulforaphane. | Bioorganic & medicinal chemistry letters 20100415 |
| Role of lipid peroxidation in cellular responses to D,L-sulforaphane, a promising cancer chemopreventive agent. | Biochemistry 20100413 |
| HPLC method validation for measurement of sulforaphane level in broccoli by-products. | Biomedical chromatography : BMC 20100401 |
| Targeting NRF2 signaling for cancer chemoprevention. | Toxicology and applied pharmacology 20100401 |
| Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels. | Pharmacological research 20100401 |
| The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy. | Diabetes 20100401 |
| Deletion of the Chd6 exon 12 affects motor coordination. | Mammalian genome : official journal of the International Mammalian Genome Society 20100401 |
| Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes. | Molecular nutrition & food research 20100401 |
| p38 MAPK plays a distinct role in sulforaphane-induced up-regulation of ARE-dependent enzymes and down-regulation of COX-2 in human bladder cancer cells. | Oncology reports 20100401 |
| Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells. | Cancer prevention research (Philadelphia, Pa.) 20100401 |
| Phytochemicals in cancer prevention and therapy: truth or dare? | Toxins 20100401 |
| Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables. | Toxins 20100401 |
| Comparison of the protective effects of steamed and cooked broccolis on ischaemia-reperfusion-induced cardiac injury. | The British journal of nutrition 20100301 |
| Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention. | The AAPS journal 20100301 |
| Sulforaphane protects against cisplatin-induced nephrotoxicity. | Toxicology letters 20100215 |
| Development of sulforaphane-encapsulated microspheres for cancer epigenetic therapy. | International journal of pharmaceutics 20100215 |
| The impact of loss of myrosinase on the bioactivity of broccoli products in F344 rats. | Journal of agricultural and food chemistry 20100210 |
| Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism. | Leukemia research 20100201 |
| Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture. | Experimental dermatology 20100201 |
| Inhibition of autophagy potentiates sulforaphane-induced apoptosis in human colon cancer cells. | Annals of surgical oncology 20100201 |
| Mouse models for unraveling the importance of diet in colon cancer prevention. | The Journal of nutritional biochemistry 20100201 |
| Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2). | Biochemical pharmacology 20100115 |
| Combination treatment with resveratrol and sulforaphane induces apoptosis in human U251 glioma cells. | Neurochemical research 20100101 |
| Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. | Journal of immunology (Baltimore, Md. : 1950) 20100101 |
| Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate. | Arthritis and rheumatism 20100101 |
| Nrf2 expression is regulated by epigenetic mechanisms in prostate cancer of TRAMP mice. | PloS one 20100101 |
| Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. | PloS one 20100101 |
| Sulforaphane Increases Cyclin-Dependent Kinase Inhibitor, p21 Protein in Human Oral Carcinoma Cells and Nude Mouse Animal Model to Induce G(2)/M Cell Cycle Arrest. | Journal of clinical biochemistry and nutrition 20100101 |
| Allyl isothiocyanate that induces GST and UGT expression confers oxidative stress resistance on C. elegans, as demonstrated by nematode biosensor. | PloS one 20100101 |
| [Effect of tBHQ and sulforaphane on Nrf2-ARE signaling pathway of Caco2 cells]. | Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100101 |
| Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease. | BMC medical genetics 20100101 |
| Pregnane X Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation. | Molecular cancer 20100101 |
| Sulforaphane induces cell cycle arrest by protecting RB-E2F-1 complex in epithelial ovarian cancer cells. | Molecular cancer 20100101 |
| Sulforaphane inhibited melanin synthesis by regulating tyrosinase gene expression in B16 mouse melanoma cells. | Bioscience, biotechnology, and biochemistry 20100101 |
| Downregulation of Epidermal Growth Factor Receptor Expression Contributes to alpha-TEA's Proapoptotic Effects in Human Ovarian Cancer Cell Lines. | Journal of oncology 20100101 |
| NADPH oxidase limits innate immune responses in the lungs in mice. | PloS one 20100101 |
| Individual variation and intraclass correlation in arachidonic acid and eicosapentaenoic acid in chicken muscle. | Lipids in health and disease 20100101 |
| Suppression of inflammatory mediators by cruciferous vegetable-derived indole-3-carbinol and phenylethyl isothiocyanate in lipopolysaccharide-activated macrophages. | Mediators of inflammation 20100101 |
| Cruciferous vegetable intake is inversely associated with lung cancer risk among smokers: a case-control study. | BMC cancer 20100101 |
| Transcript and protein profiling identify candidate gene sets of potential adaptive significance in New Zealand Pachycladon. | BMC evolutionary biology 20100101 |
| Serum glutathione transferase does not respond to indole-3-carbinol: A pilot study. | Therapeutics and clinical risk management 20100101 |
| Isothiocyanates induce oxidative stress and suppress the metastasis potential of human non-small cell lung cancer cells. | BMC cancer 20100101 |
| Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. | PloS one 20100101 |
| The dietary isothiocyanate sulforaphane modulates gene expression and alternative gene splicing in a PTEN null preclinical murine model of prostate cancer. | Molecular cancer 20100101 |
| Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. | BMC cancer 20100101 |
| Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. | Journal of molecular signaling 20100101 |
| The characterisation of AOP2: a gene associated with the biosynthesis of aliphatic alkenyl glucosinolates in Arabidopsis thaliana. | BMC plant biology 20100101 |
| The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches. | Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20100101 |
| Sulforaphane induces glutathione S-transferase isozymes which detoxify aflatoxin B(1)-8,9-epoxide in AML 12 cells. | BioFactors (Oxford, England) 20100101 |
| Protective effect of combination of sulforaphane and riluzole on glutamate-mediated excitotoxicity. | Biological & pharmaceutical bulletin 20100101 |
| Activation of CD147 with cyclophilin a induces the expression of IFITM1 through ERK and PI3K in THP-1 cells. | Mediators of inflammation 20100101 |
| Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. | Molecular cancer 20100101 |
| Sulforaphane attenuates matrix metalloproteinase-9 expression following spinal cord injury in mice. | Annals of clinical and laboratory science 20100101 |
| Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery. | International journal of cell biology 20100101 |
| Anti-cancer and potential chemopreventive actions of ginseng by activating Nrf2 (NFE2L2) anti-oxidative stress/anti-inflammatory pathways. | Chinese medicine 20100101 |
| Novel screening method for potential skin-whitening compounds by a luciferase reporter assay. | Bioscience, biotechnology, and biochemistry 20100101 |
| Purification of reversibly oxidized proteins (PROP) reveals a redox switch controlling p38 MAP kinase activity. | PloS one 20100101 |
| Cytokines in the Progression of Pancreatic β-Cell Dysfunction. | International journal of endocrinology 20100101 |
| Reactivating aberrantly hypermethylated p15 gene in leukemic T cells by a phenylhexyl isothiocyanate mediated inter-active mechanism on DNA and chromatin. | Journal of hematology & oncology 20100101 |
| Broccoli, PTEN deletion and prostate cancer: where is the link? | Molecular cancer 20100101 |
| Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells. | OncoTargets and therapy 20100101 |
| 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. | BMC cancer 20100101 |
| Expression and distribution of the class III ubiquitin-conjugating enzymes in the retina. | Molecular vision 20100101 |
| Down-regulation of phosphoglucomutase 3 mediates sulforaphane-induced cell death in LNCaP prostate cancer cells. | Proteome science 20100101 |
| Resveratrol induces growth arrest and apoptosis through activation of FOXO transcription factors in prostate cancer cells. | PloS one 20100101 |
| Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice. | Mediators of inflammation 20100101 |
| Neuroprotective role of haptoglobin after intracerebral hemorrhage. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20091216 |
| Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. | American journal of respiratory and critical care medicine 20091215 |
| Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. | The Biochemical journal 20091210 |
| Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks. | Journal of medicinal chemistry 20091210 |
| Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line. | Journal of neurochemistry 20091201 |
| Sulforaphane inhibits angiogenesis through activation of FOXO transcription factors. | Oncology reports 20091201 |
| Effect of sulforaphane on glutathione-adduct formation and on glutathione_S_transferase-dependent detoxification of acrylamide in Caco-2 cells. | Molecular nutrition & food research 20091201 |
| Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. | Parkinsonism & related disorders 20091201 |
| Sulforaphane induces G2-M arrest and apoptosis in high metastasis cell line of salivary gland adenoid cystic carcinoma. | Oral oncology 20091101 |
| Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. | Arteriosclerosis, thrombosis, and vascular biology 20091101 |
| Antioxidant anti-inflammatory treatment in type 2 diabetes. | Diabetes care 20091101 |
| Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers. | Cancer letters 20091018 |
| Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery. | Biochemical and biophysical research communications 20091016 |
| Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells. | Journal of animal physiology and animal nutrition 20091001 |
| Modulation of thioredoxin reductase-2 expression in EAhy926 cells: implications for endothelial selenoprotein hierarchy. | Biochimica et biophysica acta 20091001 |
| Pharmacokinetics and pharmacodynamics of broccoli sprouts on the suppression of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: implication of induction of Nrf2, HO-1 and apoptosis and the suppression of Akt-dependent kinase pathway. | Pharmaceutical research 20091001 |
| Sulforaphane treatment protects skeletal muscle against damage induced by exhaustive exercise in rats. | Journal of applied physiology (Bethesda, Md. : 1985) 20091001 |
| Sulforaphane destabilizes the androgen receptor in prostate cancer cells by inactivating histone deacetylase 6. | Proceedings of the National Academy of Sciences of the United States of America 20090929 |
| Gene expression profile of primary prostate epithelial and stromal cells in response to sulforaphane or iberin exposure. | The Prostate 20090915 |
| Chemopreventive agent sulforaphane enhances radiosensitivity in human tumor cells. | International journal of cancer 20090901 |
| Activation of several concurrent proapoptic pathways by sulforaphane in human colon cancer cells SW620. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090901 |
| Protective effect of sulforaphane on indomethacin-induced cytotoxicity via heme oxygenase-1 expression in human intestinal Int 407 cells. | Molecular nutrition & food research 20090901 |
| Inhibition of activator protein-1 by sulforaphane involves interaction with cysteine in the cFos DNA-binding domain: implications for chemoprevention of UVB-induced skin cancer. | Cancer research 20090901 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090901 |
| Evaluation of protective effects of sulforaphane on DNA damage caused by exposure to low levels of pesticide mixture using comet assay. | Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20090901 |
| Sulforaphane improves cognitive function administered following traumatic brain injury. | Neuroscience letters 20090828 |
| Enantiopure sulforaphane analogues with various substituents at the sulfinyl sulfur: asymmetric synthesis and biological activities. | The Journal of organic chemistry 20090821 |
| Sulforaphane enhances caspase-dependent apoptosis through inhibition of cyclooxygenase-2 expression in human oral squamous carcinoma cells and nude mouse xenograft model. | Oral oncology 20090801 |
| Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090801 |
| The effect of isothiocyanates on CYP1A1 and CYP1A2 activities induced by polycyclic aromatic hydrocarbons in Mcf7 cells. | Toxicology in vitro : an international journal published in association with BIBRA 20090801 |
| Relevance of the aryl hydrocarbon receptor (AhR) for clinical toxicology. | Clinical toxicology (Philadelphia, Pa.) 20090801 |
| Modifying the alkylglucosinolate profile in Arabidopsis thaliana alters the tritrophic interaction with the herbivore Brevicoryne brassicae and parasitoid Diaeretiella rapae. | Journal of chemical ecology 20090801 |
| Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation. | Nutrition research (New York, N.Y.) 20090801 |
| Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling. | Gut 20090701 |
| Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species. | Pharmaceutical research 20090701 |
| Sulforaphane: from chemoprevention to pancreatic cancer treatment? | Gut 20090701 |
| The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat. | Molecular nutrition & food research 20090701 |
| D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells. | Molecular cancer therapeutics 20090701 |
| Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential. | Journal of agricultural and food chemistry 20090624 |
| Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes. | The Journal of biological chemistry 20090619 |
| Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. | Toxicology and applied pharmacology 20090615 |
| Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya. | Toxicology in vitro : an international journal published in association with BIBRA 20090601 |
| Initial in vitro evaluations of the antibacterial activities of glucosinolate enzymatic hydrolysis products against plant pathogenic bacteria. | Journal of applied microbiology 20090601 |
| The antimicrobial effects of glucosinolates and their respective enzymatic hydrolysis products on bacteria isolated from the human intestinal tract. | Journal of applied microbiology 20090601 |
| Potential health benefits of broccoli- a chemico-biological overview. | Mini reviews in medicinal chemistry 20090601 |
| E. Solowiej, J. Solowiej, M. Godlewski, et al. Regarding the article 'Application of Sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats,' Transplant Proc (2006 Jan/Feb) 38(1): pages 282-283. | Transplantation proceedings 20090601 |
| Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures. | Journal of neuroscience research 20090515 |
| Effects of acid and lactone forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors on the induction of MDR1 expression and function in LS180 cells. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090512 |
| Fragrant unsaturated aldehydes elicit activation of the Keap1/Nrf2 system leading to the upregulation of thioredoxin expression and protection against oxidative stress. | Antioxidants & redox signaling 20090501 |
| Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells. | Toxicology and applied pharmacology 20090501 |
| Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation. | Glia 20090415 |
| An in vitro screening cascade to identify neuroprotective antioxidants in ALS. | Free radical biology & medicine 20090415 |
| Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds. | Environmental and molecular mutagenesis 20090401 |
| Sulforaphane down-regulates COX-2 expression by activating p38 and inhibiting NF-kappaB-DNA-binding activity in human bladder T24 cells. | International journal of oncology 20090401 |
| Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. | Cancer prevention research (Philadelphia, Pa.) 20090401 |
| Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. | Cancer letters 20090308 |
| Regulation of estrogen receptor alpha expression in human breast cancer cells by sulforaphane. | The Journal of nutritional biochemistry 20090301 |
| Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. | Phytotherapy research : PTR 20090301 |
| Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway. | Clinical immunology (Orlando, Fla.) 20090301 |
| Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms. | Antioxidants & redox signaling 20090301 |
| Chemical genomics of cancer chemopreventive dithiolethiones. | Carcinogenesis 20090301 |
| Effect of broccoli (Brassica oleracea) and its phytochemical sulforaphane in balanced diets on the detoxification enzymes levels of tilapia (Oreochromis niloticus) exposed to a carcinogenic and mutagenic pollutant. | Chemosphere 20090301 |
| Comparison of the effects of phenethyl isothiocyanate and sulforaphane on gene expression in breast cancer and normal mammary epithelial cells. | Experimental biology and medicine (Maywood, N.J.) 20090301 |
| Functionalized 3-benzylidene-indolin-2-ones: inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1) with antiproliferative activity. | Bioorganic & medicinal chemistry 20090301 |
| Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells. | Cancer research 20090301 |
| [Sulforaphane (1-isothiocyanato-4-(methylsulfinyl)-butane) content in cruciferous vegetables]. | Archivos latinoamericanos de nutricion 20090301 |
| Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. | Toxicology and applied pharmacology 20090215 |
| Sulforaphane suppresses TNF-alpha-mediated activation of NF-kappaB and induces apoptosis through activation of reactive oxygen species-dependent caspase-3. | Cancer letters 20090208 |
| Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation. | Biochemical and biophysical research communications 20090206 |
| Temporal changes in gene expression induced by sulforaphane in human prostate cancer cells. | The Prostate 20090201 |
| HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. | Toxicological sciences : an official journal of the Society of Toxicology 20090201 |
| Sulforaphane stimulates activation of proapoptotic protein bax leading to apoptosis of endothelial progenitor cells. | Annals of surgical oncology 20090201 |
| Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors. | Photodermatology, photoimmunology & photomedicine 20090201 |
| Fenugreek: a naturally occurring edible spice as an anticancer agent. | Cancer biology & therapy 20090201 |
| Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane. | Chemico-biological interactions 20090127 |
| Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. | American journal of respiratory and critical care medicine 20090115 |
| Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation. | Pharmaceutical research 20090101 |
| Receptor independent and receptor dependent CoMSA modeling with IVE-PLS: application to CBG benchmark steroids and reductase activators. | Journal of molecular modeling 20090101 |
| Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane. | Neurochemistry international 20090101 |
| Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1). | Nutrition and cancer 20090101 |
| Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases. | BMC medical genomics 20090101 |
| Protection against amyloid beta cytotoxicity by sulforaphane: role of the proteasome. | Archives of pharmacal research 20090101 |
| Sulforaphane and its analogues inhibit CYP1A1 and CYP1A2 activity induced by benzo[a]pyrene. | Journal of biochemical and molecular toxicology 20090101 |
| The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism. | Nuclear receptor signaling 20090101 |
| Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level. | PloS one 20090101 |
| Potential skin antiinflammatory effects of 4-methylthiobutylisothiocyanate (MTBI) isolated from rocket (Eruca sativa) seeds. | BioFactors (Oxford, England) 20090101 |
| Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. | PloS one 20090101 |
| New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer. | Journal of hematology & oncology 20090101 |
| Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. | PloS one 20090101 |
| Dietary agent, benzyl isothiocyanate inhibits signal transducer and activator of transcription 3 phosphorylation and collaborates with sulforaphane in the growth suppression of PANC-1 cancer cells. | Cancer cell international 20090101 |
| Modulation of markers associated with aggressive phenotype in MDA-MB-231 breast carcinoma cells by sulforaphane. | Neoplasma 20090101 |
| LAS0811: from combinatorial chemistry to activation of antioxidant response element. | Journal of biomedicine & biotechnology 20090101 |
| DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase. | PloS one 20090101 |
| Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells. | BMC cancer 20090101 |
| Dihydro-CDDO-trifluoroethyl amide (dh404), a novel Nrf2 activator, suppresses oxidative stress in cardiomyocytes. | PloS one 20090101 |
| Sulforaphane induces DNA double strand breaks predominantly repaired by homologous recombination pathway in human cancer cells. | Biochemical and biophysical research communications 20081212 |
| Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis. | British journal of cancer 20081209 |
| Isothiocyanate NB7M causes selective cytotoxicity, pro-apoptotic signalling and cell-cycle regression in ovarian cancer cells. | British journal of cancer 20081202 |
| A food-derived synergist of NGF signaling: identification of protein tyrosine phosphatase 1B as a key regulator of NGF receptor-initiated signal transduction. | Journal of neurochemistry 20081201 |
| Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane. | Carcinogenesis 20081201 |
| Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli. | Journal of agricultural and food chemistry 20081126 |
| Sulforaphane generates reactive oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937 cells. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081101 |
| Sulforaphane induces cell-cycle arrest and apoptosis in cultured human lung adenocarcinoma LTEP-A2 cells and retards growth of LTEP-A2 xenografts in vivo. | Journal of natural products 20081101 |
| Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. | Journal of natural products 20081101 |
| Epithiospecifier protein activity in broccoli: the link between terminal alkenyl glucosinolates and sulphoraphane nitrile. | Phytochemistry 20081101 |
| Sulforaphane enhances the therapeutic potential of TRAIL in prostate cancer orthotopic model through regulation of apoptosis, metastasis, and angiogenesis. | Clinical cancer research : an official journal of the American Association for Cancer Research 20081101 |
| Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane. | Toxicology 20081030 |
| Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. | Biochemical pharmacology 20081015 |
| Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. | Proceedings of the National Academy of Sciences of the United States of America 20081014 |
| Multi-targeted prevention of cancer by sulforaphane. | Cancer letters 20081008 |
| The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. | Immunology 20081001 |
| Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease. | Diabetes 20081001 |
| Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents. | Planta medica 20081001 |
| Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry. | Chemical research in toxicology 20081001 |
| Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione. | Journal of neurochemistry 20081001 |
| Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. | American journal of respiratory and critical care medicine 20080915 |
| Sulforaphane inhibited expression of hypoxia-inducible factor-1alpha in human tongue squamous cancer cells and prostate cancer cells. | International journal of cancer 20080915 |
| Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane. | Journal of agricultural and food chemistry 20080910 |
| Application of high-speed countercurrent chromatography for the isolation of sulforaphane from broccoli seed meal. | Journal of agricultural and food chemistry 20080910 |
| Computational discovery of novel low micromolar human pregnane X receptor antagonists. | Molecular pharmacology 20080901 |
| Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death. | Molecular and cellular neurosciences 20080901 |
| Cancer is a preventable disease that requires major lifestyle changes. | Pharmaceutical research 20080901 |
| Effect of (R)L-sulforaphane on 5-aminolevulinic acid-mediated photodynamic therapy. | Translational research : the journal of laboratory and clinical medicine 20080901 |
| Interaction of the isothiocyanate sulforaphane with drug disposition and metabolism: pharmacological and toxicological implications. | Current drug metabolism 20080901 |
| Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response. | Environmental health perspectives 20080901 |
| Red Cabbage (Brassica oleracea) Ameliorates Diabetic Nephropathy in Rats. | Evidence-based complementary and alternative medicine : eCAM 20080901 |
| Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. | The Journal of biological chemistry 20080808 |
| Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction. | Toxicology and applied pharmacology 20080801 |
| Genetic polymorphisms in the 5'-flanking region of human UDP-glucuronosyltransferase 2B7 affect the Nrf2-dependent transcriptional regulation. | Pharmacogenetics and genomics 20080801 |
| Stress-associated hormone, norepinephrine, increases proliferation and IL-6 levels of human pancreatic duct epithelial cells and can be inhibited by the dietary agent, sulforaphane. | International journal of oncology 20080801 |
| Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates. | Nutrition reviews 20080801 |
| Antigenotoxic properties of Eruca sativa (rocket plant), erucin and erysolin in human hepatoma (HepG2) cells towards benzo(a)pyrene and their mode of action. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080701 |
| The transcription factor Nrf2 is a therapeutic target against brain inflammation. | Journal of immunology (Baltimore, Md. : 1950) 20080701 |
| Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. | Cancer research 20080701 |
| Direct and indirect antioxidant properties of inducers of cytoprotective proteins. | Molecular nutrition & food research 20080601 |
| Translating knowledge generated by epidemiological and in vitro studies into dietary cancer prevention. | Molecular nutrition & food research 20080601 |
| Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme. | Biochemical pharmacology 20080601 |
| The diet-derived sulforaphane inhibits matrix metalloproteinase-9-activated human brain microvascular endothelial cell migration and tubulogenesis. | Molecular nutrition & food research 20080601 |
| Putative mechanisms of action for indole-3-carbinol in the prevention of colorectal cancer. | Expert opinion on therapeutic targets 20080601 |
| Growth inhibition of a spectrum of bacterial and fungal pathogens by sulforaphane, an isothiocyanate product found in broccoli and other cruciferous vegetables. | Planta medica 20080601 |
| Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress. | Investigative ophthalmology & visual science 20080601 |
| Resveratrol in prevention and treatment of common clinical conditions of aging. | Clinical interventions in aging 20080601 |
| Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells. | The Journal of allergy and clinical immunology 20080501 |
| Protective effects of an extract of young radish (Raphanus sativus L) cultivated with sulfur (sulfur-radish extract) and of sulforaphane on carbon tetrachloride-induced hepatotoxicity. | Bioscience, biotechnology, and biochemistry 20080501 |
| Sulforaphane and erucin increase MRP1 and MRP2 in human carcinoma cell lines. | The Journal of nutritional biochemistry 20080401 |
| Liquid microjunction surface sampling probe electrospray mass spectrometry for detection of drugs and metabolites in thin tissue sections. | Journal of mass spectrometry : JMS 20080401 |
| Synergistic neurotoxic effects of arsenic and dopamine in human dopaminergic neuroblastoma SH-SY5Y cells. | Toxicological sciences : an official journal of the Society of Toxicology 20080401 |
| Expression of MRP1 and GSTP1-1 modulate the acute cellular response to treatment with the chemopreventive isothiocyanate, sulforaphane. | Carcinogenesis 20080401 |
| Modulation of Nrf2-dependent antioxidant functions in the RPE by Zip2, a zinc transporter protein. | Investigative ophthalmology & visual science 20080401 |
| Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. | Investigative ophthalmology & visual science 20080401 |
| Identification, synthesis, and enzymology of non-natural glucosinolate chemopreventive candidates. | Chembiochem : a European journal of chemical biology 20080325 |
| Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat. | The British journal of nutrition 20080301 |
| Cytotoxic and antioxidant activity of 4-methylthio-3-butenyl isothiocyanate from Raphanus sativus L. (Kaiware Daikon) sprouts. | Journal of agricultural and food chemistry 20080213 |
| Synergistic effects of a combination of dietary factors sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 human colon carcinoma cells. | Pharmaceutical research 20080201 |
| The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis. | Pigment cell & melanoma research 20080201 |
| Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080109 |
| Evaluation of the safety and bioactivity of purified and semi-purified glucoraphanin. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080101 |
| Dietary factors, hormesis and health. | Ageing research reviews 20080101 |
| Sulforaphane inhibition of monocyte adhesion via the suppression of ICAM-1 and NF-kappaB is dependent upon glutathione depletion in endothelial cells. | Vascular pharmacology 20080101 |
| Prevention of Oxidative Stress-Induced Retinal Pigment Epithelial Cell Death by the PPARgamma Agonists, 15-Deoxy-Delta 12, 14-Prostaglandin J(2). | PPAR research 20080101 |
| The first generation of a BAC-based physical map of Brassica rapa. | BMC genomics 20080101 |
| Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. | PloS one 20080101 |
| Potent induction of total cellular and mitochondrial antioxidants and phase 2 enzymes by cruciferous sulforaphane in rat aortic smooth muscle cells: cytoprotection against oxidative and electrophilic stress. | Cardiovascular toxicology 20080101 |
| Induction of differentiation in human promyelocytic cells by the isothiocyanate sulforaphane. | In vivo (Athens, Greece) 20080101 |
| Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells. | Nutrition and cancer 20080101 |
| Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia. | Chinese medicine 20080101 |
| Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway. | Mediators of inflammation 20080101 |
| Strategies for prostate cancer prevention: Review of the literature. | Indian journal of urology : IJU : journal of the Urological Society of India 20080101 |
| Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells. | Drug design, development and therapy 20080101 |
| Progress and perspectives on the role of RPE cell inflammatory responses in the development of age-related macular degeneration. | Journal of inflammation research 20080101 |
| Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. | European journal of pharmacology 20071222 |
| Broccoli extract may help reduce UV skin damage. | JAMA 20071219 |
| Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter. | International immunopharmacology 20071215 |
| Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection. | Cancer letters 20071208 |
| Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity. | Toxicology and applied pharmacology 20071201 |
| Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage. | Stroke 20071201 |
| Efficacy of sulforaphane is mediated by p38 MAP kinase and caspase-7 activations in ER-positive and COX-2-expressed human breast cancer cells. | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20071201 |
| Sulforaphane induces cell cycle arrest and apoptosis in murine osteosarcoma cells in vitro and inhibits tumor growth in vivo. | Oncology reports 20071101 |
| Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. | Cancer research 20071015 |
| Separation and purification of sulforaphane from broccoli seeds by solid phase extraction and preparative high-performance liquid chromatography. | Journal of agricultural and food chemistry 20071003 |
| Dietary histone deacetylase inhibitors: from cells to mice to man. | Seminars in cancer biology 20071001 |
| Sulforaphane induces growth arrest and apoptosis in human ovarian cancer cells. | Acta obstetricia et gynecologica Scandinavica 20071001 |
| Role of NF-kappaB and MAPKs in light-induced photoreceptor apoptosis. | Investigative ophthalmology & visual science 20071001 |
| Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents. | Biological chemistry 20071001 |
| Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070919 |
| Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. | Free radical biology & medicine 20070901 |
| Keap1 eye on the target: chemoprevention of liver cancer. | Acta pharmacologica Sinica 20070901 |
| Discovery and development of sulforaphane as a cancer chemopreventive phytochemical. | Acta pharmacologica Sinica 20070901 |
| Immunomodulatory activity of Sulforaphane, a naturally occurring isothiocyanate from broccoli (Brassica oleracea). | Phytomedicine : international journal of phytotherapy and phytopharmacology 20070801 |
| Biphasic modulation of cell proliferation by sulforaphane at physiologically relevant exposure times in a human colon cancer cell line. | Molecular nutrition & food research 20070801 |
| Quantitative combination effects between sulforaphane and 3,3'-diindolylmethane on proliferation of human colon cancer cells in vitro. | Carcinogenesis 20070701 |
| Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast. | Carcinogenesis 20070701 |
| Induction of apoptosis by isothiocyanate sulforaphane in human cervical carcinoma HeLa and hepatocarcinoma HepG2 cells through activation of caspase-3. | Oncology reports 20070701 |
| The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells. | Cancer research 20070701 |
| Quinone reductase induction activity of methoxylated analogues of resveratrol. | European journal of medicinal chemistry 20070601 |
| Identification of a flavin-monooxygenase as the S-oxygenating enzyme in aliphatic glucosinolate biosynthesis in Arabidopsis. | The Plant journal : for cell and molecular biology 20070601 |
| Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. | Carcinogenesis 20070501 |
| Delay of photoreceptor degeneration in tubby mouse by sulforaphane. | Journal of neurochemistry 20070501 |
| Molecular basis for chemoprevention by sulforaphane: a comprehensive review. | Cellular and molecular life sciences : CMLS 20070501 |
| Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line. | Molecular cancer therapeutics 20070501 |
| The metabolic fate of purified glucoraphanin in F344 rats. | Journal of agricultural and food chemistry 20070418 |
| Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. | Toxicological sciences : an official journal of the Society of Toxicology 20070401 |
| Protective effect of sulforaphane against dopaminergic cell death. | The Journal of pharmacology and experimental therapeutics 20070401 |
| Effect of meal composition and cooking duration on the fate of sulforaphane following consumption of broccoli by healthy human subjects. | The British journal of nutrition 20070401 |
| Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070401 |
| Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis. | Pharmacological research 20070301 |
| Sulforaphane induces cell type-specific apoptosis in human breast cancer cell lines. | Molecular cancer therapeutics 20070301 |
| The influence of processing and preservation on the retention of health-promoting compounds in broccoli. | Journal of food science 20070301 |
| Dual action of sulforaphane in the regulation of thioredoxin reductase and thioredoxin in human HepG2 and Caco-2 cells. | Journal of agricultural and food chemistry 20070221 |
| Sulforaphane suppresses angiogenesis and disrupts endothelial mitotic progression and microtubule polymerization. | Vascular pharmacology 20070201 |
| Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. | Carcinogenesis 20070201 |
| Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage. | Nutrition (Burbank, Los Angeles County, Calif.) 20070201 |
| Variation of glucosinolates in vegetable crops of Brassica rapa. | Phytochemistry 20070201 |
| Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects. | Experimental biology and medicine (Maywood, N.J.) 20070201 |
| Sulforaphane-stimulated phase II enzyme induction inhibits cytokine production by airway epithelial cells stimulated with diesel extract. | American journal of physiology. Lung cellular and molecular physiology 20070101 |
| D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1. | Carcinogenesis 20070101 |
| The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor. | Molecular pharmacology 20070101 |
| Sulforaphane as a promising molecule for fighting cancer. | Mutation research 20070101 |
| Antiproliferative activity of sulforaphane in Akt-overexpressing ovarian cancer cells. | Molecular cancer therapeutics 20070101 |
| Differential response of human healthy lymphoblastoid and CCRF-SB leukemia cells to sulforaphane and its two analogues: 2-oxohexyl isothiocyanate and alyssin. | Pharmacological reports : PR 20070101 |
| Combination of doxorubicin and sulforaphane for reversing doxorubicin-resistant phenotype in mouse fibroblasts with p53Ser220 mutation. | Annals of the New York Academy of Sciences 20070101 |
| Diet, genetic polymorphisms, detoxification, and health risks. | Alternative therapies in health and medicine 20070101 |
| Chemoprotection against cancer: an idea whose time has come. | Alternative therapies in health and medicine 20070101 |
| Cell-cycle specificity of sulforaphane-mediated apoptosis in Jurkat T-leukemia cells. | In vivo (Athens, Greece) 20070101 |
| MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice. | BMC complementary and alternative medicine 20070101 |
| Minocycline and sulforaphane inhibited lipopolysaccharide-mediated retinal microglial activation. | Molecular vision 20070101 |
| Modulation of cell-mediated immune response in B16F-10 melanoma-induced metastatic tumor-bearing C57BL/6 mice by sulforaphane. | Immunopharmacology and immunotoxicology 20070101 |
| Antioxidant enzyme induction: a new protective approach against the adverse effects of diesel exhaust particles. | Inhalation toxicology 20070101 |
| The isothiocyanate class of bioactive nutrients covalently inhibit the MEKK1 protein kinase. | BMC cancer 20070101 |
| Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin. | Molecular cancer 20070101 |
| In vitro antiproliferative effects of sulforaphane on human colon cancer cell line SW620. | Acta medica (Hradec Kralove) 20070101 |
| Genomic loci modulating the retinal transcriptome in wound healing. | Gene regulation and systems biology 20070101 |
| Induction of GST and NQO1 in cultured bladder cells and in the urinary bladders of rats by an extract of broccoli (Brassica oleracea italica) sprouts. | Journal of agricultural and food chemistry 20061213 |
| PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex. | The Journal of biological chemistry 20061208 |
| Quantitative measurement of sulforaphane, iberin and their mercapturic acid pathway metabolites in human plasma and urine using liquid chromatography-tandem electrospray ionisation mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205 |
| Pharmacogenomics of cancer chemopreventive isothiocyanate compound sulforaphane in the intestinal polyps of ApcMin/+ mice. | Biopharmaceutics & drug disposition 20061201 |
| Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. | Cancer letters 20061118 |
| Sulforaphane increases the efficacy of doxorubicin in mouse fibroblasts characterized by p53 mutations. | Mutation research 20061010 |
| Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. | Carcinogenesis 20061001 |
| Effect of sulforaphane on cell growth, G(0)/G(1) phase cell progression and apoptosis in human bladder cancer T24 cells. | International journal of oncology 20061001 |
| Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters. | Cancer letters 20060928 |
| Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain. | The Journal of biological chemistry 20060915 |
| Fatal enterocolitis in Asian elephants (Elephas maximus) caused by Clostridium difficile. | Veterinary microbiology 20060910 |
| Sulforaphane enhances TRAIL-induced apoptosis through the induction of DR5 expression in human osteosarcoma cells. | Carcinogenesis 20060901 |
| Activation of multiple molecular mechanisms for apoptosis in human malignant glioblastoma T98G and U87MG cells treated with sulforaphane. | Neuroscience 20060901 |
| Phase II enzymes induction blocks the enhanced IgE production in B cells by diesel exhaust particles. | Journal of immunology (Baltimore, Md. : 1950) 20060901 |
| Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells. | Cancer research 20060901 |
| Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts. | Cancer letters 20060828 |
| Simultaneous determination of sulforaphane and its major metabolites from biological matrices with liquid chromatography-tandem mass spectroscopy. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060818 |
| Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2. | Cancer research 20060815 |
| Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation. | The Journal of allergy and clinical immunology 20060801 |
| Part of the series: from dietary antioxidants to regulators in cellular signaling and gene regulation. Sulforaphane and selenium, partners in adaptive response and prevention of cancer. | Free radical research 20060801 |
| Comparison of growth inhibition profiles and mechanisms of apoptosis induction in human colon cancer cell lines by isothiocyanates and indoles from Brassicaceae. | Mutation research 20060725 |
| Haplotype-environment interactions that regulate the human glutathione S-transferase P1 promoter. | Cancer research 20060615 |
| Dietary agents as histone deacetylase inhibitors. | Molecular carcinogenesis 20060601 |
| Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells. | Cancer research 20060601 |
| Antimetastatic activity of Sulforaphane. | Life sciences 20060522 |
| Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. | Cancer letters 20060508 |
| Aqueous extracts of selenium-fertilized broccoli increase selenoprotein activity and inhibit DNA single-strand breaks, but decrease the activity of quinone reductase in Hepa 1c1c7 cells. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060501 |
| Evaporative light-scattering analysis of sulforaphane in broccoli samples: Quality of broccoli products regarding sulforaphane contents. | Journal of agricultural and food chemistry 20060405 |
| Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells. | Carcinogenesis 20060401 |
| Histone deacetylases as targets for dietary cancer preventive agents: lessons learned with butyrate, diallyl disulfide, and sulforaphane. | Current drug targets 20060401 |
| Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. | Molecular cancer therapeutics 20060401 |
| Isothiocyanates stimulating oviposition by the diamondback moth, Plutella xylostella. | Journal of chemical ecology 20060401 |
| Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane. | Journal of agricultural and food chemistry 20060322 |
| Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. | Mutation research 20060320 |
| Sulforaphane, an activator of Nrf2, suppresses cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. | FEBS letters 20060320 |
| Effect of isothiocyanates on nuclear accumulation of NF-kappaB, Nrf2, and thioredoxin in caco-2 cells. | Journal of agricultural and food chemistry 20060308 |
| ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. | Carcinogenesis 20060301 |
| The phase 2 enzyme inducers ethacrynic acid, DL-sulforaphane, and oltipraz inhibit lipopolysaccharide-induced high-mobility group box 1 secretion by RAW 264.7 cells. | The Journal of pharmacology and experimental therapeutics 20060301 |
| Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301 |
| The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. | Anti-cancer drugs 20060301 |
| Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis. | Current cancer drug targets 20060301 |
| Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention. | Molecular cancer therapeutics 20060301 |
| Bioactive dammarane triterpenes from the mangrove plant Bruguiera gymnorrhiza. | Journal of natural products 20060301 |
| Quinone reductase induction as a biomarker for cancer chemoprevention. | Journal of natural products 20060301 |
| Suppressive effects of young radish cultivated with sulfur on growth and metastasis of B16-F10 melanoma cells. | Archives of pharmacal research 20060301 |
| Chemoprotection by sulforaphane: keep one eye beyond Keap1. | Cancer letters 20060227 |
| p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1. | Cancer chemotherapy and pharmacology 20060201 |
| Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention? | Carcinogenesis 20060201 |
| Dietary approaches to positively influence fetal determinants of adult health. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060201 |
| Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5. | Cancer research 20060201 |
| Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents. | Neuroscience letters 20060130 |
| Cancer chemopreventive activity of sulforamate derivatives. | European journal of medicinal chemistry 20060101 |
| Application of sulforaphane: histopathological study of intraportal transplanted pancreatic islets into livers of diabetic rats. | Transplantation proceedings 20060101 |
| Modest induction of phase 2 enzyme activity in the F-344 rat prostate. | BMC cancer 20060101 |
| Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment. | Rejuvenation research 20060101 |
| Sulforaphane induces inhibition of human umbilical vein endothelial cells proliferation by apoptosis. | Angiogenesis 20060101 |
| Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study. | Nutrition and cancer 20060101 |
| Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity. | Cutaneous and ocular toxicology 20060101 |
| Augmentation of natural killer cell and antibody-dependent cellular cytotoxicity in BALB/c mice by sulforaphane, a naturally occurring isothiocyanate from broccoli through enhanced production of cytokines IL-2 and IFN-gamma. | Immunopharmacology and immunotoxicology 20060101 |
| Ethanol sensitivity: a central role for CREB transcription regulation in the cerebellum. | BMC genomics 20060101 |
| Sulforaphane inhibits osteoclastogenesis by inhibiting nuclear factor-kappaB. | Molecules and cells 20051231 |
| Purification of sulforaphane from Brassica oleracea seed meal using low-pressure column chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051215 |
| Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. | Toxicology and applied pharmacology 20051201 |
| Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens. | Environmental and molecular mutagenesis 20051201 |
| Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells. | Carcinogenesis 20051201 |
| Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane. | Chemical research in toxicology 20051201 |
| An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (noni). | Journal of natural products 20051201 |
| Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury. | Journal of neuroscience research 20051115 |
| Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. | International journal of cancer 20051110 |
| Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20051101 |
| [Effects of sulforaphane-rich broccoli sprouts on H. pylori-infected gastric mucosa]. | Nihon rinsho. Japanese journal of clinical medicine 20051101 |
| Chinese cabbage extracts and sulforaphane can protect H2O2-induced inhibition of gap junctional intercellular communication through the inactivation of ERK1/2 and p38 MAP kinases. | Journal of agricultural and food chemistry 20051019 |
| Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells. | International journal of molecular medicine 20051001 |
| Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy. | Clinical cancer research : an official journal of the American Association for Cancer Research 20051001 |
| Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice. | Cancer research 20050915 |
| Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo. | Cancer chemotherapy and pharmacology 20050901 |
| Detoxication enzyme inducers modify cytokine production in rat mixed glial cells. | Journal of neuroimmunology 20050901 |
| Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes. | Journal of cellular biochemistry 20050815 |
| Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif. | The Journal of biological chemistry 20050805 |
| Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. | Molecular cancer therapeutics 20050801 |
| Phytochemicals in broccoli transcriptionally induce thioredoxin reductase. | Journal of agricultural and food chemistry 20050713 |
| Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells. | Oncogene 20050630 |
| Nrf2 as a novel molecular target for chemoprevention. | Cancer letters 20050628 |
| A mutated p53 status did not prevent the induction of apoptosis by sulforaphane, a promising anti-cancer drug. | Investigational new drugs 20050601 |
| Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells. | Biochemical pharmacology 20050601 |
| Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. | The Journal of biological chemistry 20050520 |
| Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein. | Biochemistry 20050510 |
| Overexpression of regucalcin suppresses apoptotic cell death in the cloned rat hepatoma H4-II-E cells induced by a naturally occurring isothiocyanate sulforaphane. | International journal of molecular medicine 20050501 |
| Direct antioxidant activity of purified glucoerucin, the dietary secondary metabolite contained in rocket (Eruca sativa Mill.) seeds and sprouts. | Journal of agricultural and food chemistry 20050406 |
| Micronucleus formation and induction of apoptosis by different isothiocyanates and a mixture of isothiocyanates in human lymphocyte cultures. | Mutation research 20050404 |
| Inhibition of cell cycle and induction of apoptosis by sulforaphane in cell lines carrying various inherited BRCA1 mutations. | Oncology reports 20050401 |
| Evaluation of the antimicrobial effects of several isothiocyanates on Helicobacter pylori. | Planta medica 20050401 |
| Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. | Journal of biochemistry and molecular biology 20050331 |
| [Induction of uridine 5'-diphosphate-glucuronosyltransferase gene expression by sulforaphane and its mechanism: experimental study in human colon cancel cells]. | Zhonghua yi xue za zhi 20050330 |
| Sulforaphane, erucin, and iberin up-regulate thioredoxin reductase 1 expression in human MCF-7 cells. | Journal of agricultural and food chemistry 20050309 |
| Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice. | Investigative ophthalmology & visual science 20050301 |
| Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent. | Cancer research 20050301 |
| Induction of phase I, II and III drug metabolism/transport by xenobiotics. | Archives of pharmacal research 20050301 |
| Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. | Biochemical and biophysical research communications 20050218 |
| Red maca (Lepidium meyenii) reduced prostate size in rats. | Reproductive biology and endocrinology : RB&E 20050101 |
| Animal models and analytical approaches for understanding the relationships between wine and cancer. | Drugs under experimental and clinical research 20050101 |
| Isothiocyanates induce cell cycle arrest, apoptosis and mitochondrial potential depolarization in HL-60 and multidrug-resistant cell lines. | Anticancer research 20050101 |
| Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells. | Journal of medicinal food 20050101 |
| Cultivation conditions and selenium fertilization alter the phenolic profile, glucosinolate, and sulforaphane content of broccoli. | Journal of medicinal food 20050101 |
| Involvement of c-Jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by sulforaphane in DU145 prostate cancer cells. | Nutrition and cancer 20050101 |
| Role of the nrf-2 gene in protection and repair of gastric mucosa against oxidative stress. | Inflammopharmacology 20050101 |
| Time-dependent modulation of thioredoxin reductase activity might contribute to sulforaphane-mediated inhibition of NF-kappaB binding to DNA. | Antioxidants & redox signaling 20050101 |
| Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells. | Toxicology letters 20041128 |
| Ebselen augments its peroxidase activity by inducing nrf-2-dependent transcription. | Archives of biochemistry and biophysics 20041115 |
| Phase II enzyme inducer, sulforaphane, inhibits UVB-induced AP-1 activation in human keratinocytes by a novel mechanism. | Molecular carcinogenesis 20041101 |
| Sulforaphane halts breast cancer cell growth. | Drug discovery today 20041101 |
| Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo. | British journal of cancer 20041018 |
| The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. | Molecular cancer therapeutics 20041001 |
| Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells. | Biochemical pharmacology 20040915 |
| Interactions between sulforaphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. | Carcinogenesis 20040901 |
| Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines. | Experimental biology and medicine (Maywood, N.J.) 20040901 |
| A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. | Cancer research 20040815 |
| Oral broccoli sprouts for the treatment of Helicobacter pylori infection: a preliminary report. | Digestive diseases and sciences 20040801 |
| In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat. | The Journal of pharmacology and experimental therapeutics 20040701 |
| Phytochemical-induced changes in gene expression of carcinogen-metabolizing enzymes in cultured human primary hepatocytes. | Xenobiotica; the fate of foreign compounds in biological systems 20040701 |
| Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. | The Journal of biological chemistry 20040611 |
| Broccoli consumption and chronic atrophic gastritis among Japanese males: an epidemiological investigation. | Acta medica Okayama 20040601 |
| Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli. | Phytochemistry 20040501 |
| Induction of phase II detoxification enzymes in rats by plant-derived isothiocyanates: comparison of allyl isothiocyanate with sulforaphane and related compounds. | Journal of agricultural and food chemistry 20040407 |
| Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. | Pharmaceutical research 20040401 |
| Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. | Pharmaceutical research 20040401 |
| Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium. | Integrative cancer therapies 20040301 |
| Glucoraphanin and 4-hydroxyglucobrassicin contents in seeds of 59 cultivars of broccoli, raab, kohlrabi, radish, cauliflower, brussels sprouts, kale, and cabbage. | Journal of agricultural and food chemistry 20040225 |
| Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates. | Cancer letters 20040210 |
| Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040204 |
| Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. | Carcinogenesis 20040201 |
| Induction of medulloblastoma cell apoptosis by sulforaphane, a dietary anticarcinogen from Brassica vegetables. | Cancer letters 20040108 |
| Induction of cytochrome P450, generation of oxidative stress and in vitro cell-transforming and DNA-damaging activities by glucoraphanin, the bioprecursor of the chemopreventive agent sulforaphane found in broccoli. | Carcinogenesis 20040101 |
| Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. | Carcinogenesis 20040101 |
| Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention. | International journal of oncology 20040101 |
| Sulforaphane inhibits growth of a colon cancer cell line. | Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20040101 |
| Effects of different processing methods on induction of quinone reductase by dietary broccoli in rats. | Journal of medicinal food 20040101 |
| Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases. | Anticancer research 20040101 |
| Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3. | Nutrition and cancer 20040101 |
| Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells. | Nutrition and cancer 20040101 |
| Sulforaphane-mediated induction of a phase 2 detoxifying enzyme NAD(P)H:quinone reductase and apoptosis in human lymphoblastoid cells. | Acta biochimica Polonica 20040101 |
| Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. | Nutrition and cancer 20040101 |
| Application of sulforaphane--does it lead to improvement of islet graft survival after warm and/or cold ischemia. | Annals of transplantation 20040101 |
| Sulforaphane and quercetin modulate PhIP-DNA adduct formation in human HepG2 cells and hepatocytes. | Carcinogenesis 20031201 |
| Sulforaphane modulates cell cycle and apoptosis in transformed and non-transformed human T lymphocytes. | Annals of the New York Academy of Sciences 20031201 |
| Expression of the aflatoxin B1-8,9-epoxide-metabolizing murine glutathione S-transferase A3 subunit is regulated by the Nrf2 transcription factor through an antioxidant response element. | Molecular pharmacology 20031101 |
| Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. | Cancer research 20031101 |
| Selected isothiocyanates rapidly induce growth inhibition of cancer cells. | Molecular cancer therapeutics 20031001 |
| Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. | The Biochemical journal 20030901 |
| Thioredoxin reductase in human hepatoma cells is transcriptionally regulated by sulforaphane and other electrophiles via an antioxidant response element. | The Journal of nutrition 20030901 |
| Potential cncer chemopreventive flavonoids from the stems of Tephrosia toxicaria. | Journal of natural products 20030901 |
| Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase. | Journal of natural products 20030901 |
| Voltammetric and electrochemical quartz crystal microbalance studies of sulforaphane and its Zn(II) complexes. | Journal of pharmaceutical and biomedical analysis 20030808 |
| Isolation and characterization of miscellaneous secondary metabolites of Deprea subtriflora. | Journal of natural products 20030801 |
| Naturally occurring Phe151Leu substitution near a conserved folding module lowers stability of glutathione transferase P1-1. | Biochimica et biophysica acta 20030626 |
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. | The Journal of biological chemistry 20030613 |
| Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. | Drug metabolism and disposition: the biological fate of chemicals 20030601 |
| Food matrix effects on bioactivity of broccoli-derived sulforaphane in liver and colon of F344 rats. | Journal of agricultural and food chemistry 20030521 |
| Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). | Journal of natural products 20030501 |
| Differential responses from seven mammalian cell lines to the treatments of detoxifying enzyme inducers. | Life sciences 20030404 |
| The effect of indole-3-carbinol and sulforaphane on a prostate cancer cell line. | ANZ journal of surgery 20030301 |
| Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation. | Carcinogenesis 20030301 |
| Inhibition of mutagenicity of food-derived heterocyclic amines by sulforaphane--a constituent of broccoli. | Indian journal of experimental biology 20030301 |
| Chemoprevention of cancerogenesis--the role of sulforaphane. | Acta poloniae pharmaceutica 20030101 |
| [Herb honey containing sulforaphane-aglycone with potential use in cancer prophylaxis]. | Roczniki Panstwowego Zakladu Higieny 20030101 |
| Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells. | Oncology reports 20030101 |
| Benzyl isothiocyanate: an effective inhibitor of polycyclic aromatic hydrocarbon tumorigenesis in A/J mouse lung. | Cancer letters 20021210 |
| Plant-derived biomolecules in fermented cabbage. | Journal of agricultural and food chemistry 20021106 |
| Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase. | Journal of natural products 20021101 |
| Cyclin D3 and p53 mediate sulforaphane-induced cell cycle delay and apoptosis in non-transformed human T lymphocytes. | Cellular and molecular life sciences : CMLS 20021101 |
| Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea Var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymes. | Journal of agricultural and food chemistry 20021009 |
| Pharmacogenomics, regulation and signaling pathways of phase I and II drug metabolizing enzymes. | Current drug metabolism 20021001 |
| Effect of organic isothiocyanates on the P-glycoprotein- and MRP1-mediated transport of daunomycin and vinblastine. | Pharmaceutical research 20021001 |
| Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. | Cancer research 20020915 |
| Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi. | Journal of medicinal chemistry 20020829 |
| Sulforaphane and its glutathione conjugate but not sulforaphane nitrile induce UDP-glucuronosyl transferase (UGT1A1) and glutathione transferase (GSTA1) in cultured cells. | Carcinogenesis 20020801 |
| Glucosinolates of seven medicinal plants from Thailand. | Fitoterapia 20020601 |
| Glucosinolate research in the Arabidopsis era. | Trends in plant science 20020601 |
| High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. | The Biochemical journal 20020515 |
| Induction of quinone reductase by withanolides. | Journal of natural products 20020501 |
| Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. | Carcinogenesis 20020401 |
| Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. | International journal of oncology 20020301 |
| A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway. | The Journal of biological chemistry 20020201 |
| Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. | Clinica chimica acta; international journal of clinical chemistry 20020201 |
| The drug efflux pump MRP2: regulation of expression in physiopathological situations and by endogenous and exogenous compounds. | Cell biology and toxicology 20020101 |
| The cruciferous nitrile crambene has bioactivity similar to sulforaphane when administered to Fischer 344 rats but is far less potent in cell culture. | Nutrition and cancer 20020101 |
| Micronutrients and the regulation of cancerous cell growth and death: effect of sulforaphane, an isothiocyanate from broccoli. | IARC scientific publications 20020101 |
| Botanicals in cancer chemoprevention. | Cancer metastasis reviews 20020101 |
| Comparison of the bioactivity of two glucoraphanin hydrolysis products found in broccoli, sulforaphane and sulforaphane nitrile. | Journal of agricultural and food chemistry 20011201 |
| Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes. | Carcinogenesis 20011201 |
| The impaired glutathione system and its up-regulation by sulforaphane in vascular smooth muscle cells from spontaneously hypertensive rats. | Journal of hypertension 20011001 |
| Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens. | Mutation research 20010901 |
| Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010901 |
| Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. | Chemical research in toxicology 20010901 |
| A review of cancer chemopreventive agents. | Current medicinal chemistry 20010901 |
| Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms. | The Journal of biological chemistry 20010824 |
| The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. | Cancer research 20010415 |
| Study of the role of antimicrobial glucosinolate-derived isothiocyanates in resistance of Arabidopsis to microbial pathogens. | Plant physiology 20010401 |
| Preparative HPLC method for the purification of sulforaphane and sulforaphane nitrile from Brassica oleracea. | Journal of agricultural and food chemistry 20010401 |
| Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. | Biochemical and biophysical research communications 20010323 |
| Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates. | Carcinogenesis 20010301 |
| The importance of using scientific principles in the development of medicinal agents from plants. | Academic medicine : journal of the Association of American Medical Colleges 20010301 |
| Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis. | The Plant cell 20010301 |
| Inhibition of CYP2E1 with natural agents may be a feasible strategy for minimizing the hepatotoxicity of ethanol. | Medical hypotheses 20010101 |
| Induction of xenobiotic enzymes by the MAP kinase pathway and the antioxidant or electrophile response element (ARE/EpRE). | Drug metabolism reviews 20010101 |
| Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane. | Chemical research in toxicology 20000401 |
| Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels. | Carcinogenesis 19981101 |
| Electrophile and antioxidant regulation of enzymes that detoxify carcinogens. | Proceedings of the National Academy of Sciences of the United States of America 19950912 |
| Reversible conjugation of isothiocyanates with glutathione catalyzed by human glutathione transferases. | Biochemical and biophysical research communications 19950117 |
| A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. | Proceedings of the National Academy of Sciences of the United States of America 19920315 |