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Gw 788388

CAS No.:
452342-67-5
Catalog Number:
AG00376S
Molecular Formula:
C25H23N5O2
Molecular Weight:
425.4824
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
95%
In Stock USA
United States
$9
- +
100mg
95%
In Stock USA
United States
$18
- +
Product Description
Catalog Number:
AG00376S
Chemical Name:
Gw 788388
CAS Number:
452342-67-5
Molecular Formula:
C25H23N5O2
Molecular Weight:
425.4824
MDL Number:
MFCD20527321
IUPAC Name:
N-(oxan-4-yl)-4-[4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridin-2-yl]benzamide
InChI:
InChI=1S/C25H23N5O2/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31)
InChI Key:
SAGZIBJAQGBRQA-UHFFFAOYSA-N
SMILES:
O=C(c1ccc(cc1)c1nccc(c1)c1c[nH]nc1c1ccccn1)NC1CCOCC1
UNII:
N14114957J
Properties
Complexity:
605  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
425.185g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
425.492g/mol
Monoisotopic Mass:
425.185g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
92.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease. PLoS neglected tropical diseases 20120601
2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling. Bioorganic & medicinal chemistry letters 20110915
Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction. American journal of physiology. Heart and circulatory physiology 20100501
Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis. Arthritis and rheumatism 20100301
The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology 20080601
Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis. Kidney international 20080301
Inhibition of ALK5 signaling induces physeal dysplasia in rats. Toxicologic pathology 20070201
Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor. Journal of medicinal chemistry 20060406
Properties