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Thiocolchicoside

CAS No.:
602-41-5
Catalog Number:
AG003747
Molecular Formula:
C27H33NO10S
Molecular Weight:
563.6166
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
98%(HPLC)
In Stock USA
United States
$157
- +
1g
98%(HPLC)
In Stock USA
United States
$473
- +
Product Description
Catalog Number:
AG003747
Chemical Name:
Thiocolchicoside
CAS Number:
602-41-5
Molecular Formula:
C27H33NO10S
Molecular Weight:
563.6166
MDL Number:
MFCD07995056
IUPAC Name:
N-[(7S)-1,2-dimethoxy-10-methylsulfanyl-9-oxo-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
InChI:
InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
InChI Key:
LEQAKWQJCITZNK-AXHKHJLKSA-N
SMILES:
OC[C@H]1O[C@@H](Oc2cc3CC[C@@H](c4c(c3c(c2OC)OC)ccc(c(=O)c4)SC)NC(=O)C)[C@@H]([C@H]([C@@H]1O)O)O
EC Number:
210-017-7
UNII:
T1X8S697GT
Properties
Complexity:
1010  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0
Exact Mass:
563.183g/mol
Formal Charge:
0
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
563.618g/mol
Monoisotopic Mass:
563.183g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
189A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.4  
Literature
Title Journal
Chemotherapy drugs form ion pores in membranes due to physical interactions with lipids. Chemical biology & drug design 20121201
The effect of thiocolchicoside on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit. Acta neurochirurgica 20120801
Clinical comparative study: efficacy and tolerability of tolperisone and thiocolchicoside in acute low back pain and spinal muscle spasticity. Asian spine journal 20120601
Thiocolchicoside suppresses osteoclastogenesis induced by RANKL and cancer cells through inhibition of inflammatory pathways: a new use for an old drug. British journal of pharmacology 20120401
Thiocolchicoside a semi-synthetic derivative of the Glory Lily: a new weapon to fight metastatic bone resorption? British journal of pharmacology 20120401
Forced degradation study of thiocolchicoside: characterization of its degradation products. Journal of pharmaceutical and biomedical analysis 20120305
Evaluation of in vitro effects of some analgesic drugs on erythrocyte and recombinant carbonic anhydrase I and II. Journal of enzyme inhibition and medicinal chemistry 20120201
Iontophoresis: a potential emergence of a transdermal drug delivery system. Scientia pharmaceutica 20120101
New Stability-Indicating RP-HPLC Method for Determination of Diclofenac Potassium and Metaxalone from their Combined Dosage Form. Scientia pharmaceutica 20120101
An IgE immediate reaction to thiocolchicoside. International journal of immunopathology and pharmacology 20120101
Drug Eruptions: An 8-year Study Including 106 Inpatients at a Dermatology Clinic in Turkey. Indian journal of dermatology 20120101
Therapeutic intervention for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): a systematic review and meta-analysis. PloS one 20120101
To evaluate efficacy and safety of fixed dose combination of aceclofenac + paracetamol + thiocolchicoside (acenac-MR) in the treatment of acute low back pain. Journal of the Indian Medical Association 20120101
Combined occlusal and pharmacological therapy in the treatment of temporo-mandibular disorders. European review for medical and pharmacological sciences 20111101
Benefit of using muscle relaxants in the routine treatment protocol of oral submucosal fibrosis: a pilot study. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India 20111001
Safety of subcutaneous microinjections (mesotherapy) in musicians. Medical problems of performing artists 20110601
Critical review on medicinally potent plant species: Gloriosa superba. Fitoterapia 20110401
Thiocolchicoside-induced liver injury. Clinics (Sao Paulo, Brazil) 20110301
Simultaneous HPLC determination of thiocolchicoside and glafenine as well as thiocolchicoside and floctafenine in their combined dosage forms. Journal of chromatographic science 20110201
Simultaneous estimation of etoricoxib and thiocolchicoside by RP-HPLC method in combined dosage forms. Acta poloniae pharmaceutica 20110101
Effectiveness of lumbar zygapophysial joint blockage for low back pain. Turkish neurosurgery 20110101
Effects of some drugs on human erythrocyte glucose 6-phosphate dehydrogenase: an in vitro study. Journal of enzyme inhibition and medicinal chemistry 20101201
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method. Healthcare informatics research 20101201
Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer. Cancer prevention research (Philadelphia, Pa.) 20101101
[Usefulness of botulinum toxin injections in the treatment of postoperative pain after cervical spine surgery: Preliminary results]. Neuro-Chirurgie 20101001
[A rare cause of cyanosis: Sulphaemoglobinaemia related to thiocolchicoside (Miorel)]. Revue des maladies respiratoires 20100101
High-performance thin-layer chromatographic determination of etoricoxib and thiocolchicoside in combined tablet dosage form. Journal of AOAC International 20100101
The efficacy of topical thiocolchicoside (Muscoril) in the treatment of acute cervical myofascial pain syndrome: a single-blind, randomized, prospective, phase IV clinical study. Agri : Agri (Algoloji) Dernegi'nin Yayin organidir = The journal of the Turkish Society of Algology 20090701
Epileptic seizure after treatment with thiocolchicoside. Therapeutics and clinical risk management 20090101
Effect of interlaminar epidural steroid injection in acute and subacute pain due to lumbar disk herniation: a randomized comparison of 2 different protocols. The open orthopaedics journal 20090101
Penetration and distribution of thiocolchicoside through human skin: comparison between a commercial foam (Miotens) and a drug solution. AAPS PharmSciTech 20081201
Embolia cutis medicamentosa following thiocolchicoside injection. Journal of the European Academy of Dermatology and Venereology : JEADV 20080801
Efficacy of thiocolchicoside in Indian patients suffering from low back pain associated with muscle spasm. Journal of the Indian Medical Association 20080501
Efficacy and safety of eperisone in patients with low back pain: a double blind randomized study. European review for medical and pharmacological sciences 20080101
Novel 3-O-glycosyl-3-demethylthiocolchicines as ligands for glycine and gamma-aminobutyric acid receptors. Journal of medicinal chemistry 20070503
A placebo-controlled comparison of the efficiency of triple- and monotherapy in category III B chronic pelvic pain syndrome (CPPS). European urology 20070401
Thiocolchicoside inhibits the activity of various subtypes of recombinant GABA(A) receptors expressed in Xenopus laevis oocytes. European journal of pharmacology 20070308
UV-Vis spectrophotometrical and analytical methodology for the determination of singlet oxygen in new antibacterials drugs. Analytical chemistry insights 20070101
Skin atrophy caused by thiocolchicoside injections. International journal of dermatology 20061201
The muscle relaxant thiocolchicoside is an antagonist of GABAA receptor function in the central nervous system. Neuropharmacology 20060901
Ultraviolet absorbance detection of colchicine and related alkaloids on a capillary electrophoresis microchip. Analytica chimica acta 20060721
Assessment of efficacy and psychomotor performances of thiocolchicoside and tizanidine in patients with acute low back pain. International journal of clinical practice 20050701
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report. Brain tumor pathology 20050101
Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro. Journal of pharmaceutical sciences 20041001
New metabolic and pharmacokinetic characteristics of thiocolchicoside and its active metabolite in healthy humans. Fundamental & clinical pharmacology 20040801
Focal and secondarily generalised convulsive status epilepticus induced by thiocolchicoside in the rat. Seizure 20031001
Multicenter, randomized, double-blinded, placebo-controlled trial of thiocolchicoside in acute low back pain. Joint, bone, spine : revue du rhumatisme 20030901
Determination of thiocolchicoside in its binary mixtures (thiocolchicoside-glafenine and thiocolchicoside-floctafenine) by TLC-densitometry. Farmaco (Societa chimica italiana : 1989) 20030601
Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies. International journal of pharmaceutics 20030102
Physicochemical compatibility between thiocolchicoside injections (Miotens) and pharmaceutical products frequently used for combined therapy. Farmaco (Societa chimica italiana : 1989) 20021101
Vehicle effects on in vitro skin permeation of thiocolchicoside. Die Pharmazie 20021101
Highly specific and sensitive liquid chromatography-tandem mass spectrometry method for the determination of 3-desmethylthiocolchicine in human plasma as analyte for the assessment of bioequivalence after oral administration of thiocolchicoside. Journal of chromatography. A 20020308
In vitro permeation screening of a new formulation of thiocolchicoside containing various enhancers. Drug delivery 20020101
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. Immunopharmacology and immunotoxicology 20011101
Epileptic seizures after treatment with thiocolchicoside. Epilepsia 20010801
Autoradiographic localization of [3H]thiocolchicoside binding sites in the rat brain and spinal cord. Neuropharmacology 20010601
Photosensitizing activity of thiocolchicoside: photochemical and in vitro phototoxicity studies. Die Pharmazie 20010101
Comparative bioavailability and tolerability study of two intramuscular formulations of thiocolchicoside in healthy volunteers. European journal of drug metabolism and pharmacokinetics 20010101
Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers. European journal of drug metabolism and pharmacokinetics 19950101
Binding of colchicine and thiocolchicoside to human serum proteins and blood cells. International journal of clinical pharmacology and therapeutics 19940801
Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers. Biopharmaceutics & drug disposition 19940101
Properties