Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors.

Bioorganic & medicinal chemistry 20120815

Residual dormant cancer stem-cell foci are responsible for tumor relapse after antiangiogenic metronomic therapy in hepatocellular carcinoma xenografts.

Laboratory investigation; a journal of technical methods and pathology 20120701

Randomized comparison of fixed-schedule versus response-oriented individualized induction therapy and use of ubenimex during and after consolidation therapy for elderly patients with acute myeloid leukemia: the JALSG GML200 Study.

International journal of hematology 20120701

[Determination of ubenimex in human plasma by HPLC-MS/MS].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120701

Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors.

Bioorganic & medicinal chemistry 20120615

The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria.

Antimicrobial agents and chemotherapy 20120601

Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.

Journal of medicinal chemistry 20120524

The leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120501

Synthesis of a novel series of L-isoserine derivatives as aminopeptidase N inhibitors.

Journal of enzyme inhibition and medicinal chemistry 20120401

Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum.

Eukaryotic cell 20120401

Organic anion transporters involved in the excretion of bestatin in the kidney.

Peptides 20120201

Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation.

Bioorganic & medicinal chemistry letters 20120115

Comparative biochemical and functional properties of two leucine aminopeptidases of Clonorchis sinensis.

Molecular and biochemical parasitology 20120101

Inflammation mobilizes local resources to control hyperalgesia: the role of endogenous opioid peptides.

Pharmacology 20120101

Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Cyn d 1.

International archives of allergy and immunology 20120101

Paracrine regulation of fibroblast aminopeptidase N/CD13 expression by keratinocyte-releasable stratifin.

Journal of cellular physiology 20111201

Immunocytochemistry for bestatin and its application to drug accumulation studies in rat intestine and kidney.

Journal of molecular histology 20111201

Cysteine cathepsins S and L modulate anti-angiogenic activities of human endostatin.

The Journal of biological chemistry 20111028

Changes and induction of aminopeptidase activities in response to pathogen infection during germination of pigeonpea (Cajanas cajan) seeds.

Journal of plant physiology 20111015

Design, synthesis and biological evaluation of novel 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as aminopeptidase N/CD13 inhibitors.

Bioorganic & medicinal chemistry 20111015

[Effect of APN/CD13 on bestatin enhancing all-trans-retinoic acid-inducing differentiation in NB4 cells].

Zhongguo shi yan xue ye xue za zhi 20111001

LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.

Microvascular research 20110901

Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine.

Bioorganic & medicinal chemistry 20110901

LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin.

Investigational new drugs 20110801

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1.

Nature structural & molecular biology 20110501

Small-molecule probe using dual signals to monitor leucine aminopeptidase activity.

Bioorganic & medicinal chemistry letters 20110415

Synthesis of new (-)-bestatin-based inhibitor libraries reveals a novel binding mode in the S1 pocket of the essential malaria M1 metalloaminopeptidase.

Journal of medicinal chemistry 20110324

Aminopeptidase N (CD13) as a target for cancer chemotherapy.

Cancer science 20110301

Amino-benzosuberone: a novel warhead for selective inhibition of human aminopeptidase-N/CD13.

Bioorganic & medicinal chemistry 20110215

A leukotriene A4 hydrolase-related aminopeptidase from yeast undergoes induced fit upon inhibitor binding.

Journal of molecular biology 20110211

Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors.

Bioorganic & medicinal chemistry 20110115

Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor.

Anti-cancer drugs 20110101

Characterization of a CLE processing activity.

Plant molecular biology 20110101

LYP3, a new bestatin derivative for aminopeptidase N inhibition.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20110101

Progress in the development of bestatin analogues as aminopeptidases inhibitors.

Current medicinal chemistry 20110101

Purification and characterization of porcine skeletal muscle aminopeptidase T, a novel metallopeptidase homologous to leukotriene A4 hydrolase.

Bioscience, biotechnology, and biochemistry 20110101

Ubenimex capsule improves general performance and chemotherapy related toxicity in advanced gastric cancer cases.

Asian Pacific journal of cancer prevention : APJCP 20110101

Influence of bestatin, an inhibitor of aminopeptidases, on T and B lymphocyte subsets in mice.

Polish journal of veterinary sciences 20110101

A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome.

Journal of hematology & oncology 20110101

Ultrasonic synthetic technique to manufacture a pHEMA nanopolymeric-based vaccine against the H6N2 avian influenza virus: a preliminary investigation.

International journal of nanomedicine 20110101

Prognostic Significance of NRAS Gene Mutations in Children with Acute Myelogenous Leukemia.

Mediterranean journal of hematology and infectious diseases 20110101

Effects of bestatin on phagocytic cells in cyclophosphamide-treated mice.

Pharmacological reports : PR 20110101

A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening.

Chemistry (Weinheim an der Bergstrasse, Germany) 20101203

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Impact of system L amino acid transporter 1 (LAT1) on proliferation of human ovarian cancer cells: a possible target for combination therapy with anti-proliferative aminopeptidase inhibitors.

Biochemical pharmacology 20100915

Novel aminopeptidase N (APN/CD13) inhibitors derived from 3-phenylalanyl-N'-substituted-2,6-piperidinedione.

Bioorganic & medicinal chemistry 20100815

Design, synthesis and preliminary activity evaluation of novel L-lysine derivatives as aminopeptidase N/CD13 inhibitors.

Protein and peptide letters 20100701

Crystal structure of the leucine aminopeptidase from Pseudomonas putida reveals the molecular basis for its enantioselectivity and broad substrate specificity.

Journal of molecular biology 20100521

New aromatic monoesters of alpha-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13.

Bioorganic & medicinal chemistry 20100415

Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.

Journal of medicinal chemistry 20100325

Design, synthesis and primary activity assay of bi- or tri-peptide analogues with the scaffold l-arginine as amino-peptidase N/CD13 inhibitors.

Bioorganic & medicinal chemistry 20100115

Idarubicin plus behenoyl cytarabine and 6-thioguanine compares favorably with idarubicin plus cytarabine-based regimen for children with previously untreated acute myeloid leukemia: 10-year retrospective, multicenter study in Korea.

Journal of Korean medical science 20100101

The effect of different species aminopeptidase N structure on the activity screening of aminopeptidase N inhibitor.

Biological & pharmaceutical bulletin 20100101

Novel cyclic-imide peptidomimetics as aminopeptidase N inhibitors. Design, chemistry and activity evaluation. Part I.

European journal of medicinal chemistry 20091201

A scrutiny of the biochemical pathways from Ang II to Ang-(3-4) in renal basolateral membranes.

Regulatory peptides 20091127

Stromal aminopeptidase N expression: correlation with angiogenesis in non-small-cell lung cancer.

General thoracic and cardiovascular surgery 20091101

Design, synthesis, and preliminary studies of the activity of novel derivatives of N-cinnamoyl-L-aspartic acid as inhibitors of aminopeptidase N/CD13.

Bioorganic & medicinal chemistry 20091015

Discovery of leukotriene A4 hydrolase inhibitors using metabolomics biased fragment crystallography.

Journal of medicinal chemistry 20090813

Design, synthesis and primary activity evaluation of L-arginine derivatives as amino-peptidase N/CD13 inhibitors.

Bioorganic & medicinal chemistry 20090701

Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors.

Bioorganic & medicinal chemistry 20090601

Analyzing the binding of Co(II)-specific inhibitors to the methionyl aminopeptidases from Escherichia coli and Pyrococcus furiosus.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090501

Specific aminopeptidases of excised human nasal epithelium and primary culture: a comparison of functional characteristics and gene transcripts expression.

The Journal of pharmacy and pharmacology 20090501

Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.

European journal of pharmacology 20090417

Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part I).

Bioorganic & medicinal chemistry 20090415

Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).

Bioorganic & medicinal chemistry 20090415

Design, synthesis and SAR studies of tripeptide analogs with the scaffold 3-phenylpropane-1,2-diamine as aminopeptidase N/CD13 inhibitors.

Bioorganic & medicinal chemistry 20090401

The analgesic actions of centrally administered celecoxib are mediated by endogenous opioids.

Pain 20090301

Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors.

Die Pharmazie 20090201

5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines.

Clinical neuropathology 20090101

Purification and biochemical characterization of methionine aminopeptidase (MetAP) from Mycobacterium smegmatis mc2155.

Applied biochemistry and biotechnology 20081201

Novel 3-phenylpropane-1,2-diamine derivates as inhibitors of aminopeptidase N (APN).

Bioorganic & medicinal chemistry 20081201

Bestatin, an inhibitor for aminopeptidases, modulates the production of cytokines and chemokines by activated monocytes and macrophages.

Cytokine 20081201

Development of bestatin-based activity-based probes for metallo-aminopeptidases.

Bioorganic & medicinal chemistry letters 20081115

Basidiomycete metabolites attenuate virulence properties of Candida albicans in vitro.

Mycoses 20081101

Structural basis for substrate recognition and hydrolysis by mouse carnosinase CN2.

The Journal of biological chemistry 20081003

Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.

Journal of neuroscience research 20081001

Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors.

Bioorganic & medicinal chemistry letters 20080815

CHR-2797: an antiproliferative aminopeptidase inhibitor that leads to amino acid deprivation in human leukemic cells.

Cancer research 20080815

Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold.

Bioorganic & medicinal chemistry 20080715

First synthesis of alpha-aminoalkyl-(N-substituted)thiocarbamoyl-phosphinates: inhibitors of aminopeptidase N (APN/CD13) with the new zinc-binding group.

Bioorganic & medicinal chemistry letters 20080701

Demonstration of direct binding of cIAP1 degradation-promoting bestatin analogs to BIR3 domain: Synthesis and application of fluorescent bestatin ester analogs.

Bioorganic & medicinal chemistry letters 20080601

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20080601

Design, synthesis, and QSAR studies of novel lysine derives as amino-peptidase N/CD13 inhibitors.

Bioorganic & medicinal chemistry 20080515

Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.

Bioorganic & medicinal chemistry 20080415

Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis.

Molecular and biochemical parasitology 20080301

Aminopeptidase N (APN)/CD13 inhibitor, Ubenimex, enhances radiation sensitivity in human cervical cancer.

BMC cancer 20080101

Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.

The Journal of biological chemistry 20071207

Biochemical characterization and structural prediction of a novel cytosolic leucyl aminopeptidase of the M17 family from Schizosaccharomyces pombe.

The FEBS journal 20071201

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

Journal of medicinal chemistry 20071129

Purification and identification of a novel leucine aminopeptidase from Bacillus thuringiensis israelensis.

Current microbiology 20071101

Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.

The Journal of biological chemistry 20070713

Characterization of the catalytically active Mn(II)-loaded argE-encoded N-acetyl-L-ornithine deacetylase from Escherichia coli.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20070601

Complete remission induced by gemtuzumab ozogamicin in a Jehovah's Witness patient with acute myelogenous leukemia.

International journal of hematology 20070601

Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.

International journal of cancer 20070515

Novel 3-galloylamido-N'-substituted-2,6-piperidinedione-N-acetamide peptidomimetics as metalloproteinase inhibitors.

Bioorganic & medicinal chemistry letters 20070515

Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation.

The Journal of investigative dermatology 20070501

Development of a liquid chromatography/tandem mass spectrometry assay for the determination of bestatin in rat plasma and its application to a pharmacokinetic study.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor.

Zoological science 20070501

Continuous treatment of bestatin induces anti-angiogenic property in endothelial cells.

Cancer science 20070301

In vitro transport of an allatostatin across the foregut of Manduca sexta larvae and metabolism by the gut and hemolymph.

Peptides 20070101

Characterization of thimet oligopeptidase and neurolysin activities in B16F10-Nex2 tumor cells and their involvement in angiogenesis and tumor growth.

Molecular cancer 20070101

Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.

BMC cancer 20070101

Aminopeptidase B, a glucagon-processing enzyme: site directed mutagenesis of the Zn2+-binding motif and molecular modelling.

BMC biochemistry 20070101

Crystal structure of aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli and conformational change of methionine 260 involved in substrate recognition.

The Journal of biological chemistry 20061103

Microplate assay for quantitative determination of cathepsin activities in viable cells using derivatives of 4-methoxy-beta-naphthylamide.

BioTechniques 20061001

Involvement of the 5-lipoxygenase/leukotriene A4 hydrolase pathway in 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch, and inhibition of carcinogenesis by its inhibitors.

Carcinogenesis 20060901

Identification and characterisation of a leucine aminopeptidase from the hard tick Haemaphysalis longicornis.

International journal for parasitology 20060901

Simultaneous modulation of transport and metabolism of acyclovir prodrugs across rabbit cornea: An approach involving enzyme inhibitors.

International journal of pharmaceutics 20060831

Bestatin, an inhibitor of aminopeptidases, provides a chemical genetics approach to dissect jasmonate signaling in Arabidopsis.

Plant physiology 20060801

[Experimental study of the enhancement effect of aminopeptidase N inhibitor ubenimex on the differentiation induction activity of all-trans-retinoic acid in acute promyelocytic leukemia cells and its mechanism].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20060701

CD13/Aminopeptidase N overexpression by basic fibroblast growth factor mediates enhanced invasiveness of 1F6 human melanoma cells.

British journal of cancer 20060605

Immunohistochemical expression of aminopeptidase N (CD13) in human lung squamous cell carcinomas, with special reference to Bestatin adjuvant therapy.

Pathology international 20060601

[Effect of aminopeptidase inhibitor on differentiation induction activity of all-trans retinoic acid in human acute promyelocytic leukemia NB4 cells and its mechanism].

Zhongguo shi yan xue ye xue za zhi 20060601

Aminopeptidase N (CD13) regulates tumor necrosis factor-alpha-induced apoptosis in human neutrophils.

The Journal of biological chemistry 20060505

A derivative of aminopeptidase inhibitor (BE15) has a dual inhibitory effect of invasion and motility on tumor and endothelial cells.

Biological & pharmaceutical bulletin 20060401

Overexpression of leucyl aminopeptidase in Plasmodium falciparum parasites. Target for the antimalarial activity of bestatin.

The Journal of biological chemistry 20060120

Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Medicinal research reviews 20060101

Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase.

Journal of neurochemistry 20060101

Treatment for HTLV-I associated arthropathy: a case study and synovial tissue culture analysis.

Rheumatology international 20051101

Aspirin inhibits thrombin action on endothelial cells via up-regulation of aminopeptidase N/CD13 expression.

Atherosclerosis 20051101

Novel 3-amino-2-hydroxy acids containing protease inhibitors. Part 1: Synthesis and kinetic characterization as aminopeptidase P inhibitors.

Bioorganic & medicinal chemistry 20050815

Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung.

American journal of physiology. Lung cellular and molecular physiology 20050801

Crystal structures of the tricorn interacting factor F3 from Thermoplasma acidophilum, a zinc aminopeptidase in three different conformations.

Journal of molecular biology 20050617

The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme.

Microbiology (Reading, England) 20050601

Central penetration and stability of N-terminal tripeptide of insulin-like growth factor-I, glycine-proline-glutamate in adult rat.

Neuropeptides 20050401

N-hydroxy-2-(naphthalene-2-ylsulfanyl)-acetamide, a novel hydroxamic acid-based inhibitor of aminopeptidase N and its anti-angiogenic activity.

Bioorganic & medicinal chemistry letters 20050103

Anti-tumor angiogenesis effect of aminopeptidase inhibitor bestatin against B16-BL6 melanoma cells orthotopically implanted into syngeneic mice.

Cancer letters 20041208

Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts.

Journal of the renin-angiotensin-aldosterone system : JRAAS 20041201

Identification of extra- and intracellular alanyl aminopeptidases as new targets to modulate keratinocyte growth and differentiation.

Biochemical and biophysical research communications 20040903

Chronic morphine treatment reduces recovery from opioid desensitization.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040901

Spectroscopic and X-ray crystallographic characterization of bestatin bound to the aminopeptidase from Aeromonas (Vibrio) proteolytica.

Biochemistry 20040803

Long-term cytogenetic remission with ubenimex monotherapy in a case of chronic myeloid leukemia.

Anti-cancer drugs 20040801

GPI-anchored aminopeptidase is involved in the acrosome reaction in sperm of the mussel mytilusedulis.

Molecular reproduction and development 20040401

Metabolism and absorption enhancement of methionine enkephalin in human nasal epithelium.

Peptides 20040401

Comparison of different adjuvants of protein and DNA vaccination for the prophylaxis of IgE antibody formation.

Vaccine 20040126

Fibrosis in hypertensive heart disease: focus on cardiac fibroblasts.

Journal of hypertension 20040101

Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases.

Journal of hypertension 20040101

[Leu-enkephalin homogeneously labeled with tritium in studying the Selank inhibiting effect on the enkephalin-degrading enzymes of human plasma].

Bioorganicheskaia khimiia 20040101

Aminopeptidase inhibitor bestatin stimulates microvascular endothelial cell invasion in a fibrin matrix.

Thrombosis and haemostasis 20031101

Aminopeptidase inhibitors inhibit proliferation and induce apoptosis of K562 and STI571-resistant K562 cell lines through the MAPK and GSK-3beta pathways.

Leukemia & lymphoma 20031101

[A case of renal cell carcinoma with lymph node metastasis keeping remission for five years by adjuvant immunotherapy with ubenimex].

Gan to kagaku ryoho. Cancer & chemotherapy 20031001

Synthesis and biological evaluation of novel flavone-8-acetic acid derivatives as reversible inhibitors of aminopeptidase N/CD13.

Journal of medicinal chemistry 20030828

[Chemotherapy with ubenimex corresponding to patient age and organ disorder for 18 cases of acute myelogeneous leukemia in elderly patients--effects, complications and long-term survival].

Gan to kagaku ryoho. Cancer & chemotherapy 20030801

Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.

Chemistry & biology 20030801

Leukotriene A4 signaling, inflammation, and cancer.

Journal of the National Cancer Institute 20030716

Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin.

Journal of the National Cancer Institute 20030716

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

Journal of drug targeting 20030701

The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.

Journal of medicinal chemistry 20030619

Bestatin selectively suppresses the growth of leukemic stem/progenitor cells with BCR/ABL mRNA transcript in patients with chronic myelogeneous leukemia.

International immunopharmacology 20030601

Bestatin results in pathophysiological changes similar to preeclampsia in rats via induction of placental apoptosis.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030601

Aminopeptidase N inhibitors and SARS.

Lancet (London, England) 20030503

Randomized double-blind placebo-controlled trial of bestatin in patients with resected stage I squamous-cell lung carcinoma.

Journal of the National Cancer Institute 20030416

A comparative study on the rectal aminopeptidase enzymatic activities of different species.

Die Pharmazie 20030301

Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

Enhancement of sensitivity by bestatin of acute promyelocytic leukemia NB4 cells to all-trans retinoic acid.

Leukemia research 20021201

Induction of graft-versus-host disease and a graft-versus-leukemia effect using ubenimex in a patient with infantile leukemia relapsing after an unrelated cord blood transplant.

Bone marrow transplantation 20021001

Characterization of aminopeptidase activity from three species of microsporidia: Encephalitozoon cuniculi, Encephalitozoon hellem, and Vittaforma corneae.

The Journal of parasitology 20021001

Effect of Bacillus anthracis lethal toxin on human peripheral blood mononuclear cells.

FEBS letters 20020911

CD13/aminopeptidase N-induced lymphocyte involvement in inflamed joints of patients with rheumatoid arthritis.

Arthritis and rheumatism 20020901

Aminopeptidase inhibitors bestatin and actinonin inhibit cell proliferation of myeloma cells predominantly by intracellular interactions.

Cancer letters 20020828

Effects of naloxone and post-tetanic stimulation on isolated guinea-pig ileum followed by long exposure to morphine and bestatin.

The Journal of toxicological sciences 20020801

Cloning and characterization of a leucyl aminopeptidase from three pathogenic Leishmania species.

The Journal of biological chemistry 20020719

Leukemic cell-surface CD13/aminopeptidase N and resistance to apoptosis mediated by endothelial cells.

Journal of the National Cancer Institute 20020703

Inhibition of fiber cell globulization and hyperglycemia-induced lens opacification by aminopeptidase inhibitor bestatin.

Investigative ophthalmology & visual science 20020701

Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.

Placenta 20020701

Membrane-associated dipeptidyl peptidase IV is involved in encystation-specific gene expression during Giardia differentiation.

The Biochemical journal 20020615

Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

The Journal of biological chemistry 20020419

Role of CD13/aminopeptidase N in rat lymphocytic alveolitis caused by thoracic irradiation.

Radiation research 20020201

Characterization of a cytosolic aminopeptidase from Encephalitozoon intestinalis.

Parasitology 20020101

Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide.

Journal of molecular neuroscience : MN 20020101

Zinc and Manduca sexta hemocyte functions.

Journal of insect science (Online) 20020101

The neuropeptide FF analogue, 1DMe, acts as a functional opioid autoreceptor antagonist in the rat spinal cord.

European journal of pharmacology 20011102

Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans.

The Journal of pharmacy and pharmacology 20011101

Augmentation of death ligand-induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines.

International journal of cancer 20011101

[Effects of ubenimex ( bestatin) on the immunity of patients with squamous cell lung carcinoma treated with chemotherapy].

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20011020

Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase.

The Journal of biological chemistry 20010928

The role of aminopeptidases in haemoglobin degradation in Plasmodium falciparum-infected erythrocytes.

Molecular and biochemical parasitology 20010928

Studies on the aminopeptidase activities of Porphyromonas gingivalis.

Oral microbiology and immunology 20010801

[Aminopeptidase inhibitor Bestatin induces HL-60 cell apoptosis through activating caspase 3].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20010701

Expression of attractin and its differential enzyme activity in glioma cells.

Biochemical and biophysical research communications 20010608

Effects of dipeptide bestatin on Porphyromonas gingivalis and epithelial cells.

Journal of periodontology 20010601

Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.

Journal of immunology (Baltimore, Md. : 1950) 20010501

Aminopeptidase N regulated by zinc in human prostate participates in tumor cell invasion.

International journal of cancer 20010401

Different types of antagonism by losartan and irbesartan on the effects of angiotensin II and its degradation products in rabbit arteries.

Fundamental & clinical pharmacology 20010401

Bestatin as an experimental tool in mammals.

Current drug metabolism 20010301

Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation.

Nature structural biology 20010201

Characterization of the pro-aminopeptidase from Aeromonas caviae T-64.

Bioscience, biotechnology, and biochemistry 20010201

Purification and characterization of an aminopeptidase from the edible basidiomycete Grifola frondosa.

Bioscience, biotechnology, and biochemistry 20010201

Adult T-cell leukemia associated with gastric carcinoma: report of a case.

Surgery today 20010101

In vitro and in vivo evaluation of aminopeptidase inhibitors as antimicrosporidial therapies.

The Journal of eukaryotic microbiology 20010101

Bestatin-mediated inhibition of leucine aminopeptidase may hinder HIV infection.

Antiviral research 19971201

Cryptosporidium parvum metalloaminopeptidase inhibitors prevent in vitro excystation.

Antimicrobial agents and chemotherapy 19961201

In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.

Peptides 19960101

Metabolism of aspartame by human and pig intestinal microvillar peptidases.

The Biochemical journal 19940315

Inhibition of bovine lens leucine aminopeptidase by bestatin: number of binding sites and slow binding of this inhibitor.

Biochemistry 19930126

Protease activities in carp retina.

Neurochemistry international 19921201

Feedback inhibition of met-enkephalin release from the rat spinal cord in vivo.

Synapse (New York, N.Y.) 19920501

Opioid control of the in vitro release of cholecystokinin-like material from the rat substantia nigra.

Journal of neurochemistry 19920301

alpha-Keto amide inhibitors of aminopeptidases.

Journal of medicinal chemistry 19920207

Inhibition of tumor invasion and extracellular matrix degradation by ubenimex (bestatin).

Clinical & experimental metastasis 19920101

[Combination therapy of chronic myelogenous leukemia with busulfan and bestatin].

Gan to kagaku ryoho. Cancer & chemotherapy 19910401

Leukotriene A4 hydrolase. Inhibition by bestatin and intrinsic aminopeptidase activity establish its functional resemblance to metallohydrolase enzymes.

The Journal of biological chemistry 19910125

Tonic suppression of baroreceptor reflex by endogenous neurotensin in the rat.

Regulatory peptides 19900327

Role of a serine endopeptidase in the hydrolysis of exogenous cholecystokinin by brain slices.

Neuroscience 19890101

Effects of bestatin and phosphoramidon on the hypertensive response to physostigmine in the rat.

Fundamental & clinical pharmacology 19870101

Isolation of two forms of the high-molecular-mass serine protease, ingensin, from porcine skeletal muscle.

FEBS letters 19850909