Home Other Building Blocks (5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione

(5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione

CAS No.:
900515-16-4
Catalog Number:
AG0036ZS
Molecular Formula:
C14H8FNO4S
Molecular Weight:
305.2810
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$185
- +
10mg
99%
1 week
United States
$290
- +
Product Description
Catalog Number:
AG0036ZS
Chemical Name:
(5Z)-5-{[5-(4-Fluoro-2-hydroxyphenyl)furan-2-yl]methylidene}-1,3-thiazolidine-2,4-dione
CAS Number:
900515-16-4
Molecular Formula:
C14H8FNO4S
Molecular Weight:
305.2810
MDL Number:
MFCD12024675
IUPAC Name:
(5Z)-5-[[5-(4-fluoro-2-hydroxyphenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
InChI:
InChI=1S/C14H8FNO4S/c15-7-1-3-9(10(17)5-7)11-4-2-8(20-11)6-12-13(18)16-14(19)21-12/h1-6,17H,(H,16,18,19)/b12-6-
InChI Key:
OYYVWNDMOQPMGE-SDQBBNPISA-N
SMILES:
O=C1S/C(=C\c2ccc(o2)c2ccc(cc2O)F)/C(=O)N1
UNII:
63D4RUV1GN
Properties
Complexity:
484  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
305.016g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
305.279g/mol
Monoisotopic Mass:
305.016g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
105A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.7  
Literature
Title Journal
Pharmacological profile of phosphatidylinositol 3-kinases and related phosphatidylinositols mediating endothelin(A) receptor-operated native TRPC channels in rabbit coronary artery myocytes. British journal of pharmacology 20120801
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation. Nature chemical biology 20120429
Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors. Cancer research 20120201
Phosphoinositide-3-kinase/akt - dependent signaling is required for maintenance of [Ca(2+)](i), I(Ca), and Ca(2+) transients in HL-1 cardiomyocytes. Journal of biomedical science 20120101
A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance. Molecular cancer research : MCR 20110701
Key role of phosphoinositide 3-kinase class IB in pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20101015
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma. Journal of medicinal chemistry 20060629
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Properties