Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity.

The Journal of biological chemistry 20170407

Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.

Chemical research in toxicology 20161219

Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations.

Nucleic acids research 20161215

Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis.

Chemical research in toxicology 20160119

Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition.

International journal of biological sciences 20160101

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Chemical research in toxicology 20151116

Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells.

Toxicological sciences : an official journal of the Society of Toxicology 20151101

Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.

Toxicology in vitro : an international journal published in association with BIBRA 20151001

SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer.

Oncogene 20150813

Arsenic-induced S phase cell cycle lengthening is associated with ROS generation, p53 signaling and CDC25A expression.

Chemico-biological interactions 20150805

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.

Molecular and cellular biology 20150801

Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.

Toxicology letters 20150716

FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.

Toxicology letters 20150702

Checkpoint kinase 1 is activated and promotes cell survival after exposure to sulphur mustard.

Toxicology letters 20150122

Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.

Toxicology and applied pharmacology 20141215

Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.

Cancer research 20141001

Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.

Cell death & disease 20140801

Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway.

Chemico-biological interactions 20140605

Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells.

The Journal of toxicological sciences 20140601

The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.

The Journal of biological chemistry 20140411

Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.

International journal of molecular medicine 20140401

Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene.

Chemico-biological interactions 20140305

Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray.

Environmental toxicology 20131101

p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.

Toxicology and applied pharmacology 20130615

Autophagy takes place in mutated p53 neuroblastoma cells in response to hypoxia mimetic CoCl(2).

Biochemical pharmacology 20130415

p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.

Inflammation 20130401

Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages.

Toxicology in vitro : an international journal published in association with BIBRA 20130401

Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells.

The Journal of toxicological sciences 20130101

Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes.

Molecular and cellular biochemistry 20121201

Adenovirus-mediated expression of p33(ING1b) induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro.

Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20121001

The synthetic purine reversine selectively induces cell death of cancer cells.

Journal of cellular biochemistry 20121001

Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway.

Stem cells and development 20120901

Novel multiple apoptotic mechanism of shikonin in human glioma cells.

Annals of surgical oncology 20120901

Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway.

Cell biology international 20120801

Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells.

Journal of inorganic biochemistry 20120801

Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage.

Toxicological sciences : an official journal of the Society of Toxicology 20120601

Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.

Molecular cancer research : MCR 20120601

The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells.

Biochemical and biophysical research communications 20120413

Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis.

Metabolism: clinical and experimental 20120401

Functional characterization of the p53 binding site in the human PYNOD promoter.

Human immunology 20120401

p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage.

CNS neuroscience & therapeutics 20120401

XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway.

Biochemical and biophysical research communications 20120323

Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

Biochemical pharmacology 20120315

P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.

Free radical research 20120301

MicroRNA-34a upregulation during seizure-induced neuronal death.

Cell death & disease 20120301

Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.

American journal of physiology. Lung cellular and molecular physiology 20120215

Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain.

Stroke 20120201

Evidence for activation of mutated p53 by apigenin in human pancreatic cancer.

Biochimica et biophysica acta 20120201

The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.

American journal of physiology. Renal physiology 20120115

p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation.

PloS one 20120101

Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells.

PloS one 20120101

2,3,7,8-Tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1.

Chemical research in toxicology 20111219

Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-α, an inhibitor of p53.

Mutation research 20111127

Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin.

Molecular and cellular biochemistry 20111101

NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.

American journal of physiology. Cell physiology 20111101

[Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells].

Yao xue xue bao = Acta pharmaceutica Sinica 20111101

Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells.

Toxicology and applied pharmacology 20111001

Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis.

Journal of cellular physiology 20110901

Inhibition of p53-p21 pathway promotes the differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.

Molecular and cellular biochemistry 20110801

SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.

American journal of physiology. Renal physiology 20110801

Targeting the p53 pathway to protect the neonatal ischemic brain.

Annals of neurology 20110801

PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway.

Shock (Augusta, Ga.) 20110601

[Effects of hot shock protein 70 inhibitor PFTµ on inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells and mice underwent myocardial ischemia-reperfusion injury].

Zhonghua xin xue guan bing za zhi 20110601

Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms.

Experimental cell research 20110501

Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β.

Life sciences 20110425

Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart.

Cardiovascular research 20110401

Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide.

Free radical biology & medicine 20110315

Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.

Blood 20110303

Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture.

Journal of molecular and cellular cardiology 20110301

Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors.

Bioorganic & medicinal chemistry 20110301

Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features.

Acta biochimica et biophysica Sinica 20110201

Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis.

World journal of gastroenterology 20110128

Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons.

British journal of pharmacology 20110101

p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury.

American journal of nephrology 20110101

Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-α.

Cell transplantation 20110101

Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel.

PloS one 20110101

Autophagy impairment induces premature senescence in primary human fibroblasts.

PloS one 20110101

High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α.

Journal of nutritional science and vitaminology 20110101

Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells.

Chemico-biological interactions 20101205

Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells.

Radiation research 20101101

Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.

American journal of physiology. Cell physiology 20101101

Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.

American journal of physiology. Cell physiology 20101101

Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells.

International journal of oncology 20101101

A role for p53 in the beta-amyloid-mediated regulation of the lysosomal system.

Neurobiology of aging 20101001

Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.

Cancer biology & therapy 20100915

p53 Plays an important role in cell fate determination after exposure to microcystin-LR.

Environmental health perspectives 20100901

Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53.

Mutation research 20100814

Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells.

Experimental biology and medicine (Maywood, N.J.) 20100801

Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.

Biochemical pharmacology 20100701

Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment.

International journal of oncology 20100701

Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma.

International journal of cancer 20100401

Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.

Molecular and cellular biochemistry 20100401

Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.

Biochimica et biophysica acta 20100401

Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene.

Toxicological sciences : an official journal of the Society of Toxicology 20100401

A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.

Cell cycle (Georgetown, Tex.) 20100401

5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.

Leukemia research 20100301

Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100301

Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

Blood 20100204

Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

The Journal of pharmacology and experimental therapeutics 20100101

Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line.

Toxicological sciences : an official journal of the Society of Toxicology 20100101

Activation of p53 promotes renal injury in acute aristolochic acid nephropathy.

Journal of the American Society of Nephrology : JASN 20100101

Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides.

Journal of neurochemistry 20100101

PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.

Biochemical and biophysical research communications 20100101

Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity.

Frontiers in bioscience (Elite edition) 20100101

Sodium orthovanadate inhibits p53-mediated apoptosis.

Cancer research 20100101

The zebrafish embryo as a model for assessing off-target drug effects.

Disease models & mechanisms 20100101

Pifithrin-α, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.

Pharmacology 20100101

Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells.

Biomedica : revista del Instituto Nacional de Salud 20100101

Angiotensin II-induced p53-dependent cardiac apoptotic cell death: its prevention by metallothionein.

Toxicology letters 20091215

Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells.

Chemico-biological interactions 20091210

Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

American journal of physiology. Heart and circulatory physiology 20091201

p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms.

The European journal of neuroscience 20091201

Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells.

Mutagenesis 20091101

NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.

Archives of biochemistry and biophysics 20090901

Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells.

Cancer investigation 20090801

Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis.

Toxicological sciences : an official journal of the Society of Toxicology 20090801

Role of p53 in human chondrocyte apoptosis in response to shear strain.

Arthritis and rheumatism 20090801

Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.

Biotechnology and applied biochemistry 20090709

Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway.

International journal of oncology 20090701

Humic acid induces G1 phase arrest and apoptosis in cultured vascular smooth muscle cells.

Environmental toxicology 20090601

Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.

Cell death and differentiation 20090601

The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.

Cell cycle (Georgetown, Tex.) 20090601

Differential requirement for nucleostemin in embryonic stem cell and neural stem cell viability.

Stem cells (Dayton, Ohio) 20090501

Delayed treatment with a p53 inhibitor enhances recovery in stroke brain.

Annals of neurology 20090501

Divergence to apoptosis from ROS induced cell cycle arrest: effect of cadmium.

Mutation research 20090426

Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.

Journal of neurochemistry 20090401

p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum.

Autophagy 20090401

Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation.

Human reproduction (Oxford, England) 20090301

The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling.

The Journal of biological chemistry 20090213

Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line.

Toxicology in vitro : an international journal published in association with BIBRA 20090201

Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia.

Stroke 20090201

Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells.

Biochemistry. Biokhimiia 20090201

Bmp2 is required for cephalic neural tube closure in the mouse.

Developmental dynamics : an official publication of the American Association of Anatomists 20090101

Ammonia-induced activation of p53 in cultured astrocytes: role in cell swelling and glutamate uptake.

Neurochemistry international 20090101

Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy.

Molecular cancer 20090101

p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.

Cancer research 20081215

p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.

American journal of physiology. Renal physiology 20081201

Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathways.

Cancer letters 20081128

Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119

Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion.

Shock (Augusta, Ga.) 20081101

Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts.

Experimental dermatology 20081101

PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development.

Toxicological sciences : an official journal of the Society of Toxicology 20081101

p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism.

Blood 20081101

ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes.

American journal of physiology. Heart and circulatory physiology 20081101

The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.

Molecular pharmacology 20081001

Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells.

Human reproduction (Oxford, England) 20081001

Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells.

Kidney international 20080901

Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition.

Anesthesia and analgesia 20080901

Coupling of mutated Met variants to DNA repair via Abl and Rad51.

Cancer research 20080715

Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20080611

p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

Oncogene 20080605

Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis.

Apoptosis : an international journal on programmed cell death 20080601

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.

Neoplasia (New York, N.Y.) 20080601

Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation.

Free radical biology & medicine 20080515

Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.

Cell cycle (Georgetown, Tex.) 20080501

Restriction of human herpesvirus 6B replication by p53.

The Journal of general virology 20080501

HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest.

American journal of physiology. Heart and circulatory physiology 20080401

Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat.

Chinese medical journal 20080305

Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.

International journal of oncology 20080101

Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest.

Mechanisms of development 20080101

Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53.

Pharmacological research 20080101

MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201

Bid is not required for Bax translocation during UV-induced apoptosis.

Cellular signalling 20071201

Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation.

Apoptosis : an international journal on programmed cell death 20071201

Temozolomide induces senescence but not apoptosis in human melanoma cells.

British journal of cancer 20071105

Activation and involvement of p53 in cisplatin-induced nephrotoxicity.

American journal of physiology. Renal physiology 20071001

Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin.

Apoptosis : an international journal on programmed cell death 20071001

Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest.

Journal of cellular physiology 20070901

Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.

Cell death and differentiation 20070801

Transcription factor p53 in degenerating spinal cords.

Brain research 20070530

NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53.

Brain research 20070511

Zebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin-alpha.

Cancer biology & therapy 20070501

Endogenously generated hydrogen peroxide induces apoptosis via mitochondrial damage independent of NF-kappaB and p53 activation in bovine embryos.

Theriogenology 20070415

Dangerous habits of a security guard: the two faces of p53 as a drug target.

Human molecular genetics 20070415

p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury.

American journal of physiology. Renal physiology 20070201

Role of p53 in irinotecan-induced intestinal cell death and mucosal damage.

Anti-cancer drugs 20070201

Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury.

American journal of physiology. Regulatory, integrative and comparative physiology 20070101

A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells.

Autophagy 20070101

Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.

Biomedical sciences instrumentation 20070101

Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils.

Indian journal of physiology and pharmacology 20070101

p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.

American journal of respiratory and critical care medicine 20061201

Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes.

The Journal of pharmacology and experimental therapeutics 20061201

Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats.

Shock (Augusta, Ga.) 20061201

Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.

Anesthesia and analgesia 20061201

Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201

Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.

Carcinogenesis 20061101

Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism.

The Journal of pharmacology and experimental therapeutics 20061101

Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice.

Cancer research 20061001

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

Nature chemical biology 20060901

Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation.

Development (Cambridge, England) 20060901

TEL/ETV6 induces apoptosis in 32D cells through p53-dependent pathways.

Biochemical and biophysical research communications 20060825

Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation.

FEBS letters 20060807

Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade.

Free radical biology & medicine 20060715

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060701

Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage.

Stroke 20060701

Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism.

Journal of medicinal chemistry 20060615

Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells.

American journal of physiology. Heart and circulatory physiology 20060601

Evidence for p53-like-mediated stress responses in green algae.

FEBS letters 20060529

Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells.

Apoptosis : an international journal on programmed cell death 20060501

Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.

Oncogene 20060406

P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis.

American journal of respiratory cell and molecular biology 20060401

[Expression of p53 in neonatal mice following hypoxia-ischemia and effects of its inhibitor on neonatal brain injury].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060401

Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis.

Toxicology and applied pharmacology 20060315

Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.

Carcinogenesis 20060301

Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway.

Growth factors (Chur, Switzerland) 20060301

Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53.

Clinical cancer research : an official journal of the American Association for Cancer Research 20060201

[Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy].

Zhonghua yi xue za zhi 20060110

Effects of intracellular calcium chelation and pifithrin-alpha on deoxynucleotide metabolism in human lymphocytes.

Nucleosides, nucleotides & nucleic acids 20060101

Pifithrin-alpha induced p53 inhibition does not affect liver regeneration after partial hepatectomy in mice.

Journal of hepatology 20051101

Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha.

Journal of medicinal chemistry 20051006

p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury.

The Journal of biological chemistry 20050902

Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol.

Toxicological sciences : an official journal of the Society of Toxicology 20050901

Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins.

Journal of the American Society of Nephrology : JASN 20050901

Regulation of neuronal P53 activity by CXCR 4.

Molecular and cellular neurosciences 20050901

An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines.

Molecular cancer therapeutics 20050901

Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050901

Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide.

International journal of cancer 20050820

The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.

The Journal of pharmacology and experimental therapeutics 20050801

Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Cancer research 20050801

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.

Neuron 20050707

Prospective therapeutic applications of p53 inhibitors.

Biochemical and biophysical research communications 20050610

Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050501

Activation of p53/p21Waf1/Cip1 pathway by 5-aza-2'-deoxycytidine inhibits cell proliferation, induces pro-apoptotic genes and mitogen-activated protein kinases in human prostate cancer cells.

International journal of oncology 20050401

Quinolinium salt as a potent inhibitor of lymphocyte apoptosis.

Bioorganic & medicinal chemistry letters 20050401

Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53.

Gynecologic oncology 20050401

Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.

Bioorganic & medicinal chemistry letters 20050315

Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time.

Neurobiology of disease 20050301

Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.

The Journal of nutrition 20050301

5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.

The Journal of pharmacology and experimental therapeutics 20050201

Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.

Toxicological sciences : an official journal of the Society of Toxicology 20050201

Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

Chemico-biological interactions 20050115

DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.

Hippocampus 20050101

The p53 inhibitor pifithrin-alpha forms a sparingly soluble derivative via intramolecular cyclization under physiological conditions.

Molecular pharmaceutics 20050101

Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.

The Journal of biological chemistry 20041231

Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth.

International journal of cancer 20041220

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.

American journal of physiology. Renal physiology 20041201

Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.

Circulation 20041123

Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis.

Nucleosides, nucleotides & nucleic acids 20041001

Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

The Journal of biological chemistry 20040716

Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.

Molecular cancer therapeutics 20040701

The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.

Experimental neurology 20040601

Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis.

Hepatology (Baltimore, Md.) 20040601

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

Oncogene 20040422

Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc.

Archives of biochemistry and biophysics 20040315

Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice.

American journal of physiology. Heart and circulatory physiology 20040301

p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.

Neuroscience letters 20040116

Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.

Journal of neuroscience research 20040101

p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning.

FEBS letters 20031204

Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.

Annals of the New York Academy of Sciences 20031201

Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

International journal of cancer 20031010

Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917

Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells.

DNA repair 20030812

Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells.

Biochemical and biophysical research communications 20030725

Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.

Free radical biology & medicine 20030701

Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.

Molecular carcinogenesis 20030701

p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.

The Journal of biological chemistry 20030502

p53 inactivation leads to impaired motor synchronization in mice.

The European journal of neuroscience 20030501

The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.

The Journal of biological chemistry 20030404

Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53.

DNA repair 20030102

P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor.

Journal of the American Society of Nephrology : JASN 20030101

p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults.

Neuromolecular medicine 20030101

Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis.

Neuroscience 20030101

The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro.

BMC molecular biology 20030101

p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

Annals of neurology 20021101

CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53.

Experimental cell research 20021101

p53 May positively regulate hepatocyte proliferation in rats.

Hepatology (Baltimore, Md.) 20020801

Acceleration of cutaneous wound healing by transient p53 inhibition.

Laboratory investigation; a journal of technical methods and pathology 20020801

Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice.

Journal of cancer research and clinical oncology 20020801

Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells.

Journal of inorganic biochemistry 20020410

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

The Journal of biological chemistry 20020329

Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis.

Genes & development 20020315

Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism.

The Journal of clinical endocrinology and metabolism 20020301

Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro.

Mutation research 20020220

Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.

DNA repair 20020122

Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.

British journal of pharmacology 20020101

Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium.

Biomedical sciences instrumentation 20020101

Regulation of functional nuclear pore size in fibroblasts.

Journal of cell science 20011201

Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes.

The Journal of biological chemistry 20010824

p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.

Oncogene 20010607

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

Journal of neurochemistry 20010401

Suppression of p53: a new approach to overcome side effects of antitumor therapy.

Biochemistry. Biokhimiia 20000101