Home Other Building Blocks Metroprolol succinate

Metroprolol succinate

CAS No.:
98418-47-4
Catalog Number:
AG0036VK
Molecular Formula:
C34H56N2O10
Molecular Weight:
652.8158
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
95%
In Stock USA
United States
$151
- +
1g
95%
In Stock USA
United States
$225
- +
5g
95%
In Stock USA
United States
$643
- +
Product Description
Catalog Number:
AG0036VK
Chemical Name:
Metroprolol succinate
CAS Number:
98418-47-4
Molecular Formula:
C34H56N2O10
Molecular Weight:
652.8158
MDL Number:
MFCD07391179
IUPAC Name:
butanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
InChI:
InChI=1S/2C15H25NO3.C4H6O4/c2*1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h2*4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChI Key:
RGHAZVBIOOEVQX-UHFFFAOYSA-N
SMILES:
OC(=O)CCC(=O)O.COCCc1ccc(cc1)OCC(CNC(C)C)O.COCCc1ccc(cc1)OCC(CNC(C)C)O
Properties
Complexity:
308  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
652.393g/mol
Formal Charge:
0
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
652.826g/mol
Monoisotopic Mass:
652.393g/mol
Rotatable Bond Count:
21  
Topological Polar Surface Area:
176A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Fasting-Induced Changes in Hepatic P450 Mediated Drug Metabolism Are Largely Independent of the Constitutive Androstane Receptor CAR. PloS one 20160101
A metoprolol-terbinafine combination induced bradycardia. European journal of drug metabolism and pharmacokinetics 20150901
Effect of Dimethoate on the Activity of Hepatic CYP450 Based on Pharmacokinetics of Probe Drugs. Pharmacology 20150101
TSC-22 up-regulates collagen 3a1 gene expression in the rat heart. BMC cardiovascular disorders 20150101
Optimized removal of dissolved organic carbon and trace organic contaminants during combined ozonation and artificial groundwater recharge. Water research 20121115
Fate of β-blockers in aquifer material under nitrate reducing conditions: batch experiments. Chemosphere 20121101
A pregnancy physiologically based pharmacokinetic (p-PBPK) model for disposition of drugs metabolized by CYP1A2, CYP2D6 and CYP3A4. British journal of clinical pharmacology 20121101
Cardioselective beta-blocker treatment of hypertension in patients with asthma: when do benefits outweigh risks? The Journal of asthma : official journal of the Association for the Care of Asthma 20121101
Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding. Macromolecular rapid communications 20121015
Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways. The Journal of biological chemistry 20121012
Pharmacokinetic interaction between metoprolol and SP-8203 in rats: competitive inhibition for the metabolism of metoprolol by SP-8203 via hepatic CYP2D subfamily. Xenobiotica; the fate of foreign compounds in biological systems 20121001
β1 -adrenergic receptor autoantibodies from heart failure patients enhanced TNF-α secretion in RAW264.7 macrophages in a largely PKA-dependent fashion. Journal of cellular biochemistry 20121001
In silico and in vivo evaluation of flavonoid extracts on CYP2D6-mediated herb-drug interaction. Journal of molecular modeling 20121001
Simultaneous enantiomeric determination of propranolol, metoprolol, pindolol, and atenolol in natural waters by HPLC on new polysaccharide-based stationary phase using a highly selective molecularly imprinted polymer extraction. Chirality 20121001
Age-dependent effect of β-blockers in preventing vasovagal syncope. Circulation. Arrhythmia and electrophysiology 20121001
Assessment of metoprolol tartrate dosage in the outpatient setting. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20121001
Clinical evaluation of valsartan and metoprolol tartrate in treatment of diabetic nephropathy with positive β1-adrenergic and anti-angiotensin II type 1 receptor antibody. Chinese medical journal 20121001
Study design for the 'effect of METOprolol in CARDioproteCtioN during an acute myocardial InfarCtion' (METOCARD-CNIC): a randomized, controlled parallel-group, observer-blinded clinical trial of early pre-reperfusion metoprolol administration in ST-segment elevation myocardial infarction. American heart journal 20121001
High-frequency ultrasound evaluation of effects of early treatment with metoprolol on myocardial inflammatory cytokine expression in rats with acute myocardial infarction. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20121001
Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity. Human & experimental toxicology 20120901
Active components of frequently used β-blockers from the aspect of computational study. Journal of molecular modeling 20120901
Nebivolol-induced vasodilation of renal afferent arterioles involves β3-adrenergic receptor and nitric oxide synthase activation. American journal of physiology. Renal physiology 20120901
Effect of the Arg389Gly β₁-adrenoceptor polymorphism on plasma renin activity and heart rate, and the genotype-dependent response to metoprolol treatment. Clinical and experimental pharmacology & physiology 20120901
Nebivolol and metoprolol: long-term effects on inflammation and oxidative stress in essential hypertension. Scandinavian journal of clinical and laboratory investigation 20120901
Studies on the metabolism of five model drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS analysis. Analytical and bioanalytical chemistry 20120901
Effect of β-blocker cessation on chronotropic incompetence and exercise tolerance in patients with advanced heart failure. Circulation. Heart failure 20120901
Carvedilol reduces the severity of atherosclerosis in apolipoprotein E-deficient mice via reducing superoxide production. Experimental biology and medicine (Maywood, N.J.) 20120901
Ask the doctors. I have had atrial fibrillation for a year, and I have felt pretty normal on a beta blocker (metoprolol) and digoxin. However, I recently began to feel very fatigued and noticed my heart rate was only 35 beats per minute. We stopped those medications, and my heart rate came up. I feel better. Are these drugs dangerous for me? Harvard heart letter : from Harvard Medical School 20120901
Beta-blockade for mitral regurgitation: could the management of valvular heart disease actually be moving into the 21st century? Journal of the American College of Cardiology 20120828
A randomized controlled phase IIb trial of beta(1)-receptor blockade for chronic degenerative mitral regurgitation. Journal of the American College of Cardiology 20120828
Cardiac responses to the intrapericardial delivery of metoprolol: targeted delivery compared to intravenous administration. Journal of cardiovascular translational research 20120801
Effects of Panax notoginseng saponins on the activities of CYP1A2, CYP2C9, CYP2D6 and CYP3A4 in rats in vivo. Phytotherapy research : PTR 20120801
Selection of optimal dose of beta-blocker treatment in myocardial infarction patients based on changes in synchronization between 0.1 Hz oscillations in heart rate and peripheral microcirculation. Journal of cardiovascular medicine (Hagerstown, Md.) 20120801
β-Blockers in heart failure: benefits of β-blockers according to varying male proportions of study patients. Clinical cardiology 20120801
Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120801
β-AR polymorphisms and glycemic and lipid parameters in hypertensive individuals receiving carvedilol or metoprolol. American journal of hypertension 20120801
Diltiazem as an alternative to beta-blocker in coronary artery computed tomography angiography. Arquivos brasileiros de cardiologia 20120801
A prospective, 1-year follow-up study of postural tachycardia syndrome. Mayo Clinic proceedings 20120801
Safety and efficacy of oral ivabradine as a heart rate-reducing agent in patients undergoing CT coronary angiography. The British journal of radiology 20120801
Usefulness of C-reactive protein as a marker of early post-infarct left ventricular systolic dysfunction. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120701
Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity. Cardiovascular research 20120701
Mutation of the calmodulin binding motif IQ of the L-type Ca(v)1.2 Ca2+ channel to EQ induces dilated cardiomyopathy and death. The Journal of biological chemistry 20120629
Identification and characterization of stressed degradation products of metoprolol using LC/Q-TOF-ESI-MS/MS and MS(n) experiments. Biomedical chromatography : BMC 20120601
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. Pharmaceutical research 20120601
β-Adrenergic receptor antagonists ameliorate myocyte T-tubule remodeling following myocardial infarction. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120601
Photochemical fate of beta-blockers in NOM enriched waters. The Science of the total environment 20120601
Successful treatment of thyrotoxic crisis after esophagectomy in an elderly woman with hyperthyroidism. The Annals of thoracic surgery 20120601
Effect of oxidative stress on ventricular arrhythmia in rabbits with adriamycin-induced cardiomyopathy. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120601
Pharmacological prevention of combat-related PTSD: a literature review. Military medicine 20120601
Influence of acute stress on cardiac electrophysiological stability in male goats. Acta cardiologica 20120601
Aquaporin changes during diabetic retinopathy in rats are accelerated by systemic hypertension and are linked to the renin-angiotensin system. Investigative ophthalmology & visual science 20120517
In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20120501
Numerical optimization studies of cardiovascular-rotary blood pump interaction. Artificial organs 20120501
Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade. Hypertension (Dallas, Tex. : 1979) 20120501
Heart rate reduction: an old and novel candidate heart failure therapy. Hypertension (Dallas, Tex. : 1979) 20120501
Therapeutic challenges and management of heart failure during pregnancy (part I). Medical science monitor : international medical journal of experimental and clinical research 20120501
Impact of norepinephrine and selective β1-adrenoceptor blockers on the growth of retinal tissue explants. Bulletin of experimental biology and medicine 20120501
Wide QRS Tachycardia in a young patient. Archives of internal medicine 20120409
Beta-blockade causes a reduction in the frequency spectrum of VF but improves resuscitation outcome: A potential limitation of quantitative waveform measures. Resuscitation 20120401
Persistence with nebivolol in the treatment of hypertension: a retrospective claims analysis. Current medical research and opinion 20120401
Differential effects of nebivolol and metoprolol on insulin sensitivity and plasminogen activator inhibitor in the metabolic syndrome. Hypertension (Dallas, Tex. : 1979) 20120401
Genetic tailoring of pharmacotherapy in heart failure: optimize the old, while we wait for something new. Journal of cardiac failure 20120401
Rapid and sensitive LC-MS/MS method for the determination of metoprolol in Beagle dog plasma with a simple protein precipitation treatment and its pharmacokinetic applications. Molecules (Basel, Switzerland) 20120305
Ketamine-induced ventricular structural, sympathetic and electrophysiological remodelling: pathological consequences and protective effects of metoprolol. British journal of pharmacology 20120301
Nadolol block of Nav1.5 does not explain its efficacy in the long QT syndrome. Journal of cardiovascular pharmacology 20120301
Longitudinal displacement and intramural shear strain of the porcine carotid artery undergo profound changes in response to catecholamines. American journal of physiology. Heart and circulatory physiology 20120301
Medication prescribing patterns among chronic kidney disease patients in a hospital in Malaysia. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia 20120301
Formulation and evaluation of delayed-onset extended-release tablets of metoprolol tartrate using hydrophilic-swellable polymers. Acta pharmaceutica (Zagreb, Croatia) 20120301
Effect of metoprolol on sarcoplasmic reticulum Ca2+ leak in a rabbit model of heart failure. Chinese medical journal 20120301
[Chiral separation of five beta-blockers using di-n-hexyl L-tartrate-boric acid complex as mobile phase additive by reversed-phase liquid chromatography]. Se pu = Chinese journal of chromatography 20120301
Pharmacophore modeling for hERG channel facilitation. Biochemical and biophysical research communications 20120203
Differential effects of metoprolol and atenolol to neuropeptide Y blockade in coronary artery disease. Scandinavian cardiovascular journal : SCJ 20120201
Preparation and optimization of PMAA-chitosan-PEG nanoparticles for oral drug delivery. Colloids and surfaces. B, Biointerfaces 20120201
Selective action of metoprolol to attenuate regadenoson-induced tachycardia in conscious dogs. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20120201
Ivabradine versus metoprolol for heart rate reduction before coronary computed tomography angiography. The American journal of cardiology 20120115
Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs. Journal of ethnopharmacology 20120106
Complex fractionated electrograms in the right atrial free wall and the superior/posterior wall of the left atrium are affected by activity of the autonomic nervous system. Journal of cardiovascular electrophysiology 20120101
β2 adrenergic-mediated reduction of blood glutamate levels and improved neurological outcome after traumatic brain injury in rats. Journal of neurosurgical anesthesiology 20120101
Beta-blocker migraine prophylaxis affects the excitability of the visual cortex as revealed by transcranial magnetic stimulation. The journal of headache and pain 20120101
Standardization of an ex vivo method for determination of intestinal permeability of drugs using everted rat intestine apparatus. Journal of pharmacological and toxicological methods 20120101
Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. Journal of hypertension 20120101
Carvedilol: a third-generation β-blocker should be a first-choice β-blocker. Expert review of cardiovascular therapy 20120101
The ups and downs of heart rate. Critical care medicine 20120101
Effects and selectivity of CL 316243, beta-3-adrenoceptor agonist, in term-pregnant rat myometrium. Gynecologic and obstetric investigation 20120101
A validated micellar LC method for simultaneous determination of furosemide, metoprolol and verapamil in human plasma. Bioanalysis 20120101
Disrupted regulation of ghrelin production under antihypertensive treatment in spontaneously hypertensive rats. Circulation journal : official journal of the Japanese Circulation Society 20120101
Benign symptomatic premature ventricular complexes: short- and long-term efficacy of antiarrhythmic drugs and radiofrequency ablation. Kardiologia polska 20120101
[Not so simple procedure in 'simple' arrhythmias of ventricular]. Kardiologia polska 20120101
Eudragit FS based colonic microparticls of metoprolol tartrate. Acta poloniae pharmaceutica 20120101
The impact of carvedilol and metoprolol on serum lipid concentrations and symptoms in patients with hyperthyroidism. Endocrine research 20120101
Atomic force mechanobiology of pluripotent stem cell-derived cardiomyocytes. PloS one 20120101
HPLC method for determination of atenolol in human plasma and application to a pharmacokinetic study in Turkey. Journal of chromatographic science 20120101
Safety and accuracy of dual-source coronary computed tomography angiography in the pediatric population. Journal of cardiovascular computed tomography 20120101
[Advantages of quinapril therapy in patients with arterial hypertension and functional class III chronic heart failure with preserved left ventricular ejection fraction]. Kardiologiia 20120101
[The methods for the protection against counterfeit medications. Part 1. The estimation of the quality of metoprolol succinate substance and tablets from different manufacturers in terms of 'identity' and 'active ingredient content']. Sudebno-meditsinskaia ekspertiza 20120101
[Diurnal profile of arterial pressure during sleep deprivation in patients with hypertensive disease receiving antihypertensive therapy]. Klinicheskaia meditsina 20120101
An evaluation of the effects of nonselective and cardioselective β-blockers on wound healing in Sprague Dawley rats. Indian journal of pharmacology 20120101
Photocatalytic degradation of metoprolol tartrate in suspensions of two TiO2-based photocatalysts with different surface area. Identification of intermediates and proposal of degradation pathways. Journal of hazardous materials 20111230
Evaluation of the chiral recognition properties as well as the column performance of four chiral stationary phases based on cellulose (3,5-dimethylphenylcarbamate) by parallel HPLC and SFC. Journal of chromatography. A 20111230
Carvedilol administration in acute myocardial infarction results in stronger inhibition of early markers of left ventricular remodeling than metoprolol. International journal of cardiology 20111215
Management of severe mitral stenosis during pregnancy. Circulation 20111213
Prediction of a new surface binding pocket and evaluation of inhibitors against huntingtin interacting protein 14: an insight using docking studies. Journal of molecular modeling 20111201
Metoprolol ameliorates cyclosporine a-induced hypertension and nephrotoxicity in rats. Journal of cardiovascular pharmacology 20111201
Peak systolic velocity indices are more sensitive than end-systolic indices in detecting contraction changes assessed by echocardiography in young healthy humans. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20111201
Carvedilol compared with metoprolol on left ventricular ejection fraction after coronary artery bypass graft. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20111201
Effect of fixed dose combinations of metoprolol and amlodipine in essential hypertension: MARS--a randomized controlled trial. Blood pressure. Supplement 20111201
Zinc tetrafluoroborate hydrate as a mild catalyst for epoxide ring opening with amines: scope and limitations of metal tetrafluoroborates and applications in the synthesis of antihypertensive drugs (RS)/(R)/(S)-metoprolols. The Journal of organic chemistry 20111104
Metoprolol-induced lichenoid dermatitis. Journal of general internal medicine 20111101
Fetopathy probably associated to self-medication with a blocker of the renin-angiotensin system. Archives of gynecology and obstetrics 20111101
Relevance of the volume-axis intercept, V0, compared with the slope of end-systolic pressure-volume relationship in response to large variations in inotropy and afterload in rats. Experimental physiology 20111101
Bromination of selected pharmaceuticals in water matrices. Chemosphere 20111101
Heart rate-associated mechanical stress impairs carotid but not cerebral artery compliance in dyslipidemic atherosclerotic mice. American journal of physiology. Heart and circulatory physiology 20111101
The role of nebivolol in the prevention of contrast-induced nephropathy in patients with renal dysfunction. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20111101
How often should atenolol be dosed for perioperative ß-blockade? Anesthesiology 20111101
[Effects of metoprolol on electrophysiology of ischemic and anoxic myocardium in diabetic rats]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20111101
Drug release control and system understanding of sucrose esters matrix tablets by artificial neural networks. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111009
Clevidipine for controlled hypotension during spinal surgery in adolescents. Journal of neurosurgical anesthesiology 20111001
Chronic β-adrenoceptor antagonist treatment controls cardiovascular remodeling in heart failure in the aging spontaneously hypertensive rat. Journal of cardiovascular pharmacology 20111001
Characterization of HCN and cardiac function in a colonial ascidian. Journal of experimental zoology. Part A, Ecological genetics and physiology 20111001
Metoprolol impairs resistance artery function in mice. Journal of applied physiology (Bethesda, Md. : 1985) 20111001
Central angiotensin (1-7) enhances baroreflex gain in conscious rabbits with heart failure. Hypertension (Dallas, Tex. : 1979) 20111001
Methylation of adrenergic β1 receptor is a potential epigenetic mechanism controlling antihypertensive response to metoprolol. Indian journal of biochemistry & biophysics 20111001
Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes. Biochemical and biophysical research communications 20110930
Why ultra high performance liquid chromatography produces more tailing peaks than high performance liquid chromatography, why it does not matter and how it can be addressed. Journal of chromatography. A 20110928
[Interactions between metoprolol and antidepressants]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20110920
Isolated dynamic left ventricular outflow tract obstruction can cause hypotension that rapidly responds to intravenous beta blockade. American journal of therapeutics 20110901
Modulation of drug (metoprolol succinate) release by inclusion of hydrophobic polymer in hydrophilic matrix. Drug development and industrial pharmacy 20110901
Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation. British journal of pharmacology 20110901
Wide complex tachycardia causing congestive heart failure. Pacing and clinical electrophysiology : PACE 20110901
A randomised study of perioperative esmolol infusion for haemodynamic stability during major vascular surgery; rationale and design of DECREASE-XIII. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20110901
The Arg389Gly β1-adrenoceptor gene polymorphism influences the acute effects of β-adrenoceptor blockade on contractility in the human heart. Clinical research in cardiology : official journal of the German Cardiac Society 20110801
Dynamic and static curing of ethylcellulose:PVA-PEG graft copolymer film coatings. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801
β-adrenergic receptor blockade reduces endoplasmic reticulum stress and normalizes calcium handling in a coronary embolization model of heart failure in canines. Cardiovascular research 20110801
The acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by β1-adrenoceptor signalling. Journal of molecular and cellular cardiology 20110801
The effects of metoprolol on hypoxia- and isoflurane-induced cardiac late-phase preconditioning. Acta anaesthesiologica Scandinavica 20110801
Improvement of left ventricular diastolic function induced by β-blockade: a comparison between nebivolol and metoprolol. Journal of molecular and cellular cardiology 20110801
β-Blockers in patients with intermittent claudication and arterial hypertension: results from the nebivolol or metoprolol in arterial occlusive disease trial. Hypertension (Dallas, Tex. : 1979) 20110801
Degradation of pharmaceutical beta-blockers by electrochemical advanced oxidation processes using a flow plant with a solar compound parabolic collector. Water research 20110801
Beta-blockers for heart failure: why you should use them more. The Journal of family practice 20110801
[Impact of metoprolol use in the treatment of patients with electrical-storm after cardioverter defibrillators implantation]. Zhonghua xin xue guan bing za zhi 20110801
Distribution of metoprolol, tramadol, and midazolam in human autopsy material. Journal of chromatography. A 20110729
Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nature medicine 20110710
Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation. Journal of pharmaceutical sciences 20110701
Hemodynamic instability during resection of pheochromocytoma in MEN versus non-MEN patients. European journal of endocrinology 20110701
The effect of metoprolol alone and combined metoprolol-felodipin on the digital microcirculation of patients with primary Raynaud's syndrome. Microvascular research 20110701
[Modulation of the beta-adrenergic system during acute myocardial infarction: rationale for a new clinical trial]. Revista espanola de cardiologia 20110701
Effects of paroxetine on the pharmacokinetics and pharmacodynamics of immediate-release and extended-release metoprolol. Pharmacotherapy 20110701
[Effect of different combined antihypertensive regimen on the erectile function in male hypertensive patients]. Zhonghua xin xue guan bing za zhi 20110701
Polymer leaching from film coating: effects on the coating transport properties. International journal of pharmaceutics 20110615
Relation of ventricular tachycardia/fibrillation to beta-blocker dose maximization guided by pacing mode analysis in nonpacemaker-dependent patients with implantable cardioverter-defibrillator. The American journal of cardiology 20110615
Beta blocker metoprolol protects against contractile dysfunction in rats after coronary microembolization by regulating expression of myocardial inflammatory cytokines. Life sciences 20110606
Cardiotoxic overdose treated with intravenous fat emulsion and high-dose insulin in the setting of hypertrophic cardiomyopathy. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20110601
Electrophysiology of anterograde right-atrial and left-atrial inputs to the atrioventricular node in patients with atrioventricular nodal re-entrant tachycardia. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110601
β-blockers as endocrine disruptors: the potential effects of human β-blockers on aquatic organisms. Journal of experimental zoology. Part A, Ecological genetics and physiology 20110601
β(1)-adrenergic receptor polymorphisms and response to β-blockade in the African-American study of kidney disease and hypertension (AASK). American journal of hypertension 20110601
Celiac artery dissection from heavy weight lifting. Journal of vascular surgery 20110601
Rate-limiting step: can different effects of antihypertensives on central blood pressure be translated into outcomes? Hypertension (Dallas, Tex. : 1979) 20110601
Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness. Hypertension (Dallas, Tex. : 1979) 20110601
Limitations of analyses based on achieved blood pressure: lessons from the African American study of kidney disease and hypertension trial. Hypertension (Dallas, Tex. : 1979) 20110601
Mixed messages on blood pressure goals. Hypertension (Dallas, Tex. : 1979) 20110601
Monomorphic ventricular tachycardia caused by arsenic trioxide therapy for acute promyelocytic leukaemia. The journal of the Royal College of Physicians of Edinburgh 20110601
Spectral data analyses and structure elucidation of metoprolol tartrate. Drug testing and analysis 20110601
Drug overdose with refractory bradycardia and hypotension. Delaware medical journal 20110601
[Therapies for postural tachycardia syndrome in children]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20110601
Chitosan in situ gelation for improved drug loading and retention in poloxamer 407 gels. International journal of pharmaceutics 20110516
Drug release mechanisms from Kollicoat SR:Eudragit NE coated pellets. International journal of pharmaceutics 20110516
Acute episode of reversible blindness after an overdose of beta blockers and calcium channel antagonist. The American journal of emergency medicine 20110501
The activation of β2-adrenergic receptors in naïve rats causes a reduction of blood glutamate levels: relevance to stress and neuroprotection. Neurochemical research 20110501
Electrochemical degradation of the β-blocker metoprolol by Ti/Ru 0.7 Ir 0.3 O 2 and Ti/SnO 2-Sb electrodes. Water research 20110501
Acute and short-term hemodynamic effects of metoprolol in Eisenmenger syndrome: a preliminary observational study. American heart journal 20110501
Fabry disease and Factor V Leiden: a potent vascular risk combination. Internal medicine journal 20110501
β-receptor antagonist treatment prevents activation of cell death signaling in the diabetic heart independent of its metabolic actions. European journal of pharmacology 20110425
Deformations of overloaded bands under pH-stable conditions in reversed phase chromatography. Journal of chromatography. A 20110415
Effect of left ventricular reverse remodeling on long-term prognosis after therapy with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and β blockers in patients with idiopathic dilated cardiomyopathy. The American journal of cardiology 20110401
Reversal of subclinical left ventricular dysfunction by antihypertensive treatment: a prospective trial of nebivolol against metoprolol. Journal of hypertension 20110401
Long-term treatment with low-dose metoprolol CR/XL is associated with increased plaque echogenicity: the Beta-blocker Cholesterol-lowering Asymptomatic Plaque Study (BCAPS). Atherosclerosis 20110401
Heart failure: acute ischemic events in HF--should we include sudden death? Nature reviews. Cardiology 20110401
Perioperative β-blockade: atenolol is associated with reduced mortality when compared to metoprolol. Anesthesiology 20110401
Association of beta-adrenergic receptor polymorphisms and mortality in carvedilol-treated chronic heart-failure patients. British journal of clinical pharmacology 20110401
The cardioprotection granted by metoprolol is restricted to its administration prior to coronary reperfusion. International journal of cardiology 20110317
Influence of metoprolol dosage release formulation on the pharmacokinetic drug interaction with paroxetine. Journal of clinical pharmacology 20110301
Contraindications and side effects of commonly used medications in coronary CT angiography. The international journal of cardiovascular imaging 20110301
Pharmacokinetics and first-pass elimination of metoprolol in rats: contribution of intestinal first-pass extraction to low bioavailability of metoprolol. Xenobiotica; the fate of foreign compounds in biological systems 20110301
Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts. American journal of physiology. Heart and circulatory physiology 20110301
Changes induced by estradiol-ethylenediamine derivative on perfusion pressure and coronary resistance in isolated rat heart: L-type calcium channel. Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20110301
Pulsatile multiparticulate drug delivery system for metoprolol succinate. Archives of pharmacal research 20110301
I've had a pacemaker for many years and have developed persistent atrial fibrillation (AF). In the past three years, I've also had episodes of ventricular tachycardia (VT). I had valve surgery six years ago and am concerned that the pacemaker lead may have been damaged during surgery. What should I know about a replacement pacemaker? Heart advisor 20110301
Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes. The journal of physical chemistry. A 20110224
Cardiac magnetic resonance aids in the diagnosis of mitochondrial cardiomyopathy. Circulation 20110215
Norepinephrine antagonists and cancer risk. International journal of cancer 20110201
Development and evaluation of injection-molded sustained-release tablets containing ethylcellulose and polyethylene oxide. Drug development and industrial pharmacy 20110201
Effects of β-adrenoceptor stimulation on delayed rectifier K(+) currents in canine ventricular cardiomyocytes. British journal of pharmacology 20110201
Cardioprotective effects of perioperative β-blockade in vascular surgery patients: fact or fiction? Current opinion in anaesthesiology 20110201
Cardiac autonomic balance in rats submitted to protein restriction after weaning. Clinical and experimental pharmacology & physiology 20110201
Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110201
Atrial fibrillation in pregnancy. Obstetrics and gynecology 20110201
β-receptor antagonist cessation resulting in tako-tsubo cardiomyopathy in a man with quadriplegia. Mayo Clinic proceedings 20110201
Has the ClOpidogrel and Metoprolol in Myocardial Infarction Trial (COMMIT) of early β-blocker use in acute coronary syndromes impacted on clinical practice in Canada? Insights from the Global Registry of Acute Coronary Events (GRACE). American heart journal 20110201
Distribution of metoprolol in human autopsy material. Die Pharmazie 20110201
Effect of permeation enhancers on the iontophoretic transport of metoprolol tartrate and the drug retention in skin. Drug delivery 20110101
Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110101
Effects of cAMP and β-adrenergic receptor antagonists on the function of peripheral T helper lymphocytes in patients with heart failure. Neuroimmunomodulation 20110101
Myoclonus after dextromethorphan administration in peritoneal dialysis. The Annals of pharmacotherapy 20110101
The effect of nebivolol versus metoprolol succinate extended release on asymmetric dimethylarginine in hypertension. Journal of the American Society of Hypertension : JASH 20110101
Effect of atenolol vs metoprolol succinate on vascular function in patients with hypertension. Clinical cardiology 20110101
Midodrine hydrochloride is effective in the treatment of children with postural orthostatic tachycardia syndrome. Circulation journal : official journal of the Japanese Circulation Society 20110101
Development and evaluation of controlled porosity osmotic pump for nifedipine and metoprolol combination. Lipids in health and disease 20110101
Iterative CT reconstruction of aortic intramural hematoma. Circulation journal : official journal of the Japanese Circulation Society 20110101
β-blockade restores muscle sympathetic rhythmicity in human heart failure. Circulation journal : official journal of the Japanese Circulation Society 20110101
[Effect of carvedilol and metoprolol R administered with or without atorvastatin on elastic properties of vascular wall and parameters of inflammation in patients with chronic heart failure of ischemic origin]. Kardiologiia 20110101
[Ischemic heart disease in elderly patients of behavioral type A (psychosocial and clinic functional changes, possibilities for correction)]. Advances in gerontology = Uspekhi gerontologii 20110101
[The influence of beta-adrenoblocking therapy on the markers of systemic inflammation in patients with acute coronary syndrome]. Klinicheskaia meditsina 20110101
Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure--a randomized study. Cardiovascular diabetology 20110101
Appreciating the medical literature: five notable articles in general internal medicine from 2009 and 2010. Open medicine : a peer-reviewed, independent, open-access journal 20110101
Transforming growth factor β₁ oppositely regulates the hypertrophic and contractile response to β-adrenergic stimulation in the heart. PloS one 20110101
Risk of periodontal disease: is there a correlation with the type of antihypertensive medication? JNMA; journal of the Nepal Medical Association 20110101
Metoprolol versus amiodarone in the prevention of atrial fibrillation after cardiac surgery: a randomized trial. Annals of internal medicine 20101207
Intravenous lipid emulsion does not augment blood pressure recovery in a rabbit model of metoprolol toxicity. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20101201
Cardioprotective effect of NO-metoprolol in murine coxsackievirus B3-induced myocarditis. Journal of medical virology 20101201
Dual renin-angiotensin system blockade for patients with prosthesis-patient mismatch. The Annals of thoracic surgery 20101201
Resistant hypertension responding to change from furosemide to thiazide: understanding calcium channel blocker-related edema. Journal of clinical hypertension (Greenwich, Conn.) 20101201
Development and optimization of metoprolol succinate gastroretentive drug delivery system. Acta pharmaceutica (Zagreb, Croatia) 20101201
Tablet splitting: Product quality assessment of metoprolol succinate extended release tablets. International journal of pharmaceutics 20101130
Morphology of new zwitterionic copolymer matrices for sustained drug release. Journal of controlled release : official journal of the Controlled Release Society 20101120
Intolerance to ß-blockade in a mouse model of δ-sarcoglycan-deficient muscular dystrophy cardiomyopathy. European journal of heart failure 20101101
Conservative treatment of spontaneous dissection of multiple coronary arteries. Heart, lung & circulation 20101101
Fish embryo toxicity of carbamazepine, diclofenac and metoprolol. Ecotoxicology and environmental safety 20101101
Changes in mitral annular geometry and dynamics with ß-blockade in patients with degenerative mitral valve disease. Circulation. Cardiovascular imaging 20101101
Cardioprotective effect of metoprolol and enalapril in doxorubicin-treated lymphoma patients: a prospective, parallel-group, randomized, controlled study with 36-month follow-up. American journal of hematology 20101101
Restraint stress induces connexin-43 translocation via α-adrenoceptors in rat heart. Circulation journal : official journal of the Japanese Circulation Society 20101101
Does remodeling of gap junctions and connexin expression contribute to arrhythmogenesis? Study in an immobilization rat model. Circulation journal : official journal of the Japanese Circulation Society 20101101
[Efficacy and safety of amiodarone and metoprolol in the treatment of ventricular premature beats: a meta-analysis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20101101
Simultaneous delivery of Nifedipine and Metoprolol tartarate using sandwiched osmotic pump tablet system. International journal of pharmaceutics 20101031
Beta-adrenergic blocking agents and dental vasoconstrictors. Dental clinics of North America 20101001
Metoprolol, but not atenolol, reduces stress induced neuropeptide Y release in pigs. Scandinavian cardiovascular journal : SCJ 20101001
The Beers criteria; antibiotic and metoprolol dosing. JAAPA : official journal of the American Academy of Physician Assistants 20101001
Quality control of metoprolol extended-release formulations in the presence of ethanol. Pharmeuropa bio & scientific notes 20101001
Metoprolol treatment lowers thrombospondin-4 expression in rats with myocardial infarction and left ventricular hypertrophy. Basic & clinical pharmacology & toxicology 20100901
Influence of beta-blocker therapy on antitachycardia pacing effectiveness for monomorphic ventricular tachycardias occurring in implantable cardioverter-defibrillator patients: a dose-dependent effect. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20100901
Indirect role of beta2-adrenergic receptors in the mechanism of analgesic action of nonsteroidal antiinflammatory drugs. Critical care medicine 20100901
The interactivities with lipid membranes differentially characterize selective and nonselective beta1-blockers. European journal of anaesthesiology 20100901
Application of a novel solid-phase-extraction sampler and ultra-performance liquid chromatography quadrupole-time-of-flight mass spectrometry for determination of pharmaceutical residues in surface sea water. Chemosphere 20100901
Association of physical training with beta-blockers in heart failure in mice. Arquivos brasileiros de cardiologia 20100901
Development of sustained release capsules containing 'coated matrix granules of metoprolol tartrate'. AAPS PharmSciTech 20100901
[Response to metoprolol succinate sustained-release tablets in correlation to pulse pressure, serum vascular endothelial growth factor and C-reactive protein in elderly hypertensive patients with chronic heart failure]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100901
Carvedilol treatment ameliorates acute coxsackievirus B3-induced myocarditis associated with oxidative stress reduction. European journal of pharmacology 20100825
The biowaiver extension for BCS class III drugs: the effect of dissolution rate on the bioequivalence of BCS class III immediate-release drugs predicted by computer simulation. Molecular pharmaceutics 20100802
Differential effects of carvedilol and metoprolol on renal function in patients with heart failure. Circulation journal : official journal of the Japanese Circulation Society 20100801
Which beta-blocker is most effective in heart failure? Cardiovascular drugs and therapy 20100801
Relation of ADRB1, CYP2D6, and UGT1A1 polymorphisms with dose of, and response to, carvedilol or metoprolol therapy in patients with chronic heart failure. The American journal of cardiology 20100801
[Effect between felodipine plus irbesartan and felodipine plus metoprolol regimen on the sexual function in young and middle-aged women with hypertension]. Zhonghua xin xue guan bing za zhi 20100801
Human DBS sampling with LC-MS/MS for enantioselective determination of metoprolol and its metabolite O-desmethyl metoprolol. Bioanalysis 20100801
[Active pharmacosurveillance of patients affiliated to the Colombian general social security/health system]. Revista de salud publica (Bogota, Colombia) 20100801
UV-C radiation based methods for aqueous metoprolol elimination. Journal of hazardous materials 20100715
Effect of DMSO on micellization, gelation and drug release profile of Poloxamer 407. International journal of pharmaceutics 20100715
Determination of metoprolol in human plasma and urine by high-performance liquid chromatography with fluorescence detection. Journal of separation science 20100701
Beta(2)-adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats. British journal of pharmacology 20100701
Kinetics of aqueous chlorination of some pharmaceuticals and their elimination from water matrices. Water research 20100701
Influence of drug treatment on glucocorticoid receptor levels in patients with coronary heart disease. Chinese medical journal 20100701
[Effects of carvedilol and metoprolol on expression of autoantibodies against cardiac adrenergic receptors in aged patients with chronic heart failure and ventricular arrhythmia]. Zhonghua xin xue guan bing za zhi 20100701
Correlation between the FT-IR characteristics and metoprolol tartrate release of methylcellulose-based patches. International journal of pharmaceutics 20100615
Renovascular hypertension in a child with Marfan syndrome. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20100611
Active cascade screening in primary inherited arrhythmia syndromes: does it lead to prophylactic treatment? Journal of the American College of Cardiology 20100608
The effects of salvianolic acid B from radix salvia miltiorrhizae on the oral pharmacokinetics of metoprolol and metoprolol acid in rats. Phytotherapy research : PTR 20100601
Comparison of drug permeabilities and BCS classification: three lipid-component PAMPA system method versus Caco-2 monolayers. The AAPS journal 20100601
A design and evaluation of layered matrix tablet formulations of metoprolol tartrate. AAPS PharmSciTech 20100601
The beta-receptor blocker metoprolol alters detoxification processes in the non-target organism Dreissena polymorpha. Environmental pollution (Barking, Essex : 1987) 20100601
Angiotensin-converting enzyme gene I/D genotype affected metoprolol-induced reduction in 24-hour average heart rate. Chinese medical journal 20100601
Selective and sensitive method for the determination of metoprolol in human plasma using liquid chromatography coupled with tandem mass spectrometry. Acta pharmaceutica (Zagreb, Croatia) 20100601
Determination of permeation resistance distribution in in vitro cell monolayer permeation experiments. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100512
A beta-adrenergic antagonist reduces traumatic memories and PTSD symptoms in female but not in male patients after cardiac surgery. Psychological medicine 20100501
Simultaneous quantitation of hydrochlorothiazide and metoprolol in human plasma by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 20100501
Aqueous coating dispersion (pseudolatex) of zein improves formulation of sustained-release tablets containing very water-soluble drug. Journal of colloid and interface science 20100501
Electrochemical degradation of beta-blockers. Studies on single and multicomponent synthetic aqueous solutions. Water research 20100501
Pulmonary hypertension: a contraindication to the use of {beta}-adrenoceptor blocking agents. Thorax 20100501
[Effect of metoprolol on the expression of GRK2 in lymphocyte of advanced elderly patients with chronic heart failure]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100501
Differences between beta-blockers in patients with chronic heart failure and chronic obstructive pulmonary disease: a randomized crossover trial. Journal of the American College of Cardiology 20100427
[Beta-blocking agents in the perioperative period of the non-cardiac surgery]. Medicina clinica 20100424
Enantioselectively controlled release of chiral drug (metoprolol) using chiral mesoporous silica materials. Nanotechnology 20100423
Deeper insight into the drug release mechanisms in Eudragit RL-based delivery systems. International journal of pharmaceutics 20100415
Autonomic control of heart rate by metabolically sensitive skeletal muscle afferents in humans. The Journal of physiology 20100401
Removal of pharmaceuticals from water: using liquid-core microcapsules as a novel approach. Water research 20100401
Evaluation of contraindications and efficacy of oral Beta blockade before computed tomographic coronary angiography. The American journal of cardiology 20100315
Atrial fibrillation degenerates into ventricular fibrillation. Journal of the American College of Cardiology 20100309
Both beta1- and beta2-adrenoceptors contribute to feedforward coronary resistance vessel dilation during exercise. American journal of physiology. Heart and circulatory physiology 20100301
Haemodynamic effects of acute intravenous metoprolol in apical ballooning syndrome with dynamic left ventricular outflow tract obstruction. European journal of heart failure 20100301
Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna--a multigenerational study. Chemosphere 20100301
Aspects on the intensity and the relief of pain in the prehospital phase of acute coronary syndrome: experiences from a randomized clinical trial. Coronary artery disease 20100301
Osmotic pumping release from ethyl-hydroxypropyl-cellulose-coated pellets: a new mechanistic model. Journal of controlled release : official journal of the Controlled Release Society 20100225
Is the intra-aortic balloon pump a method of brain protection during cardiogenic shock after drug intoxication? The Journal of emergency medicine 20100201
Atrial fibrillation in a pregnant woman with a normal heart. Internal and emergency medicine 20100201
Effects of carvedilol or metoprolol on PAI-1, tPA-mass concentration or Von Willebrand factor in chronic heart failure--a COMET substudy. Thrombosis research 20100201
Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats. Critical care medicine 20100201
Toward optimal treatment in women: the effect of sex on metoprolol-diphenhydramine interaction. Journal of clinical pharmacology 20100201
Effect of carvedilol on coronary flow reserve in patients with hypertensive left-ventricular hypertrophy. Blood pressure 20100201
Rationale and design of the beta-blocker in heart failure with normal left ventricular ejection fraction (beta-PRESERVE) study. European journal of heart failure 20100201
The effects of puerarin on CYP2D6 and CYP1A2 activities in vivo. Archives of pharmacal research 20100201
Comparative stability of repackaged metoprolol tartrate tablets. International journal of pharmaceutics 20100129
Comparison of Candesartan versus Metoprolol for treatment of systemic hypertension after repaired aortic coarctation. The American journal of cardiology 20100115
Correlation between the free volume and the metoprolol tartrate release of Metolose patches. Journal of pharmaceutical and biomedical analysis 20100105
Molecular determinants of local anesthetic action of beta-blocking drugs: Implications for therapeutic management of long QT syndrome variant 3. Journal of molecular and cellular cardiology 20100101
Levosimendan cardioprotection in acutely beta-1 adrenergic receptor blocked open chest pigs. Acta anaesthesiologica Scandinavica 20100101
Efficacy and tolerability of a fixed-dose combination of metoprolol extended release/amlodipine in patients with mild-to-moderate hypertension: a randomized, parallel-group, multicentre comparison with losartan plus amlodipine. Clinical drug investigation 20100101
A case of atrial fibrillation due to Momordica charantia (bitter melon). Annals of Saudi medicine 20100101
[Hallucinations and vivid dreams by use of metoprolol]. Tijdschrift voor psychiatrie 20100101
Cardiac gap junction channels are upregulated by metoprolol: an unexpected effect of beta-blockers. Pharmacology 20100101
[Efficacy of ivabradine in combination therapy for complicated acute coronary syndrome in patients with type 2 diabetes mellitus]. Terapevticheskii arkhiv 20100101
Metoprolol compared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes - a randomized study. Cardiovascular diabetology 20100101
Optimization and establishment of a validated stability-indicating HPLC method for study of the stress degradation behavior of metoprolol succinate. Journal of AOAC International 20100101
Design, development and in-vitro evaluation of metoprolol tartrate tablets containing xanthan-tragacanth. Acta poloniae pharmaceutica 20100101
Liver fibrosis impairs hepatic pharmacokinetics of liver transplant drugs in the rat model. Drug metabolism and pharmacokinetics 20100101
Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway. Drug metabolism and pharmacokinetics 20100101
[Summary of the practice guideline 'Atrial fibrillation' (first revision) from the Dutch College of General Practitioners]. Nederlands tijdschrift voor geneeskunde 20100101
Sleep disorders, nightmares, depression and anxiety in an elderly patient treated with low-dose metoprolol. General hospital psychiatry 20100101
[Clinical-pharmacoeconomical aspects of ß-adrenoblockers use in patients with ischemic heart disease undergoing coronary artery bypass grafting]. Kardiologiia 20100101
[Idiopathic ventricular tachycardia, an arrhythmia with good prognosis]. Nederlands tijdschrift voor geneeskunde 20100101
Bisoprolol and heart failure: new frontiers. Indian heart journal 20100101
Chirally pure S-metoprolol--place in therapy. Indian heart journal 20100101
Computed tomography angiography for right ventricular function in an adult with complex congenital heart disease. The American heart hospital journal 20100101
[Hypertensive disease and metabolic syndrome: application of metoprolol]. Klinicheskaia meditsina 20100101
[Evolution of oral drug forms of metoprolol: advantages of long acting modified release forms with modified release]. Kardiologiia 20100101
Sleep quality in patients with hypertension: additional negative effect of drug therapy. Sleep medicine 20091201
Comparison of ivabradine versus metoprolol in early phases of reperfused anterior myocardial infarction with impaired left ventricular function: preliminary findings. Journal of cardiac failure 20091201
Core-in-cup tablet design of metoprolol succinate and its evaluation for controlled release. Current drug discovery technologies 20091201
Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction. Clinical and translational science 20091201
Therapeutic innovations, diminishing returns, and control rate preservation. JAMA 20091125
Gas chromatography-mass spectrometry method for determination of metoprolol in the patients with hypertension. Talanta 20091115
Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats. Chirality 20091101
Characterisation of quaternary polymethacrylate films containing tartaric acid, metoprolol free base or metoprolol tartrate. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20091101
Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers. American journal of hypertension 20091101
Interaction of beta-blockers with the renal uptake transporter OCT2. Diabetes, obesity & metabolism 20091101
Metoprolol reduces cerebral tissue oxygen tension after acute hemodilution in rats. Anesthesiology 20091101
[Successful treatment of polymedicamentous poisoning with metoprolol, diltiazem and cilazapril]. Vojnosanitetski pregled 20091101
I have atrial fibrillation and take warfarin, digoxin and metoprolol. I still get an occasional mild attack, however. Is this normal? DukeMedicine healthnews 20091101
The experts debate: perioperative beta-blockade for noncardiac surgery--proven safe or not? Cleveland Clinic journal of medicine 20091101
Beta-blockers and non-cardiac operations what will change after the POISE study?: ?qué cambia después del estudio POISE? Arquivos brasileiros de cardiologia 20091101
[Frequent drug interactions in old age]. Praxis 20091021
Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach. Journal of pharmaceutical sciences 20091001
Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation. Cardiovascular research 20091001
Effects of AT1- and beta-adrenergic receptor antagonists on TGF-beta1-induced fibrosis in transgenic mice. European journal of clinical investigation 20091001
Modeling drug release from hot-melt extruded mini-matrices with constant and non-constant diffusivities. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20091001
Found in translation: metoprolol improves survival more than carvedilol in a mouse model of inherited dilated cardiomyopathy. Cardiovascular research 20091001
Management of cocaine-associated chest pain. Emergency medicine journal : EMJ 20091001
Right rhythm, right patient, right ventricle. The American journal of medicine 20091001
Nebivolol therapy improves endothelial function and increases exercise tolerance in patients with cardiac syndrome X. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20091001
[Beta blockers in migraine prophylaxis]. Brain and nerve = Shinkei kenkyu no shinpo 20091001
[Thrombosed giant proximal pulmonary artery aneurysm]. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20091001
Effect on the nasal bioavailability of co-processing drug and bioadhesive carrier via spray-drying. International journal of pharmaceutics 20090908
Optimization of fluid bed formulations of metoprolol granules and tablets using an experimental design. Drug development and industrial pharmacy 20090901
Dilated cardiomyopathy with hypertension: prevalence and response to high-dose β1-adrenoceptor antagonist therapy. Clinical and experimental pharmacology & physiology 20090901
The use of high-dose insulin-glucose euglycemia in beta-blocker overdose: a case report. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20090901
Time to change the paradigm? Which paradigm? Acta anaesthesiologica Scandinavica 20090901
Use of beta-blockers and effects on heart rate and blood pressure post-acute coronary syndromes: are we on target? American heart journal 20090901
The effectiveness of collaborative medicine reviews in delaying time to next hospitalization for patients with heart failure in the practice setting: results of a cohort study. Circulation. Heart failure 20090901
Influence of heat treatment on spray-dried mixtures of Amioca starch and Carbopol 974P used as carriers for nasal drug delivery. International journal of pharmaceutics 20090813
Application of kinetic resolution using HCS as chiral auxiliary: novel synthesis of beta-blockers (S)-betaxolol and (S)-metoprolol. Chirality 20090801
Design and use of a quantitative scale for measuring presyncope. Journal of cardiovascular electrophysiology 20090801
Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of ATL-146e, a highly selective adenosine A2A receptor agonist. American journal of physiology. Heart and circulatory physiology 20090801
Beta-receptor selectivity of carvedilol and metoprolol succinate in patients with heart failure (SELECT trial): a randomized dose-ranging trial. Pharmacotherapy 20090801
Right ventricular function in ST elevation myocardial infarction: effect of reperfusion. Clinical and investigative medicine. Medecine clinique et experimentale 20090801
Hypertrophic cardiomyopathy in a patient of Klinefelter syndrome--a rare association. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20090801
The effect of co-surfactant-modified micelles on chiral separations in EKC. Electrophoresis 20090801
Influence of splitting on dissolution properties of metoprolol tablets. Bosnian journal of basic medical sciences 20090801
Hemodynamic effect of myocardial bridging. Circulation. Cardiovascular interventions 20090801
Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation research 20090717
Ozonation of metoprolol: elucidation of oxidation pathways and major oxidation products. Environmental science & technology 20090715
Beta blockers for the prevention of atrial fibrillation after coronary artery bypass surgery: carvedilol versus metoprolol. International journal of cardiology 20090710
Analysis of beta-agonists and beta-blockers in urine using hollow fibre-protected liquid-phase microextraction with in situ derivatization followed by gas chromatography/mass spectrometry. Journal of chromatography. A 20090710
Prevention of perioperative atrial fibrillation with betablockers in coronary surgery: betaxolol versus metoprolol. Interactive cardiovascular and thoracic surgery 20090701
Phototransformations of selected pharmaceuticals under low-energy UVA-vis and powerful UVB-UVA irradiations in aqueous solutions--the role of natural dissolved organic chromophoric material. Analytical and bioanalytical chemistry 20090701
Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090628
Effect of metoprolol on vulnerable plaque in rabbits by changing shear stress around plaque and reducing inflammation. European journal of pharmacology 20090624
Double-chambered left ventricle with nonsustained ventricular tachycardia. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20090611
Porous pellets as drug delivery system. Drug development and industrial pharmacy 20090601
Intestinal perfusion with mesenteric blood sampling in wild-type and knockout mice: evaluation of a novel tool in biopharmaceutical drug profiling. Drug metabolism and disposition: the biological fate of chemicals 20090601
Characterization of mouse heart adenylyl cyclase. The Journal of pharmacology and experimental therapeutics 20090601
Dobutamine infusion for unmasking long QT syndrome and torsades de pointes. Clinical cardiology 20090601
CYP2D6 genotype and its relationship with metoprolol dose, concentrations and effect in patients with systolic heart failure. The pharmacogenomics journal 20090601
Prediction of modified release pharmacokinetics and pharmacodynamics from in vitro, immediate release, and intravenous data. The AAPS journal 20090601
Physical compatibility of metoprolol tartrate injection with selected cardiovascular agents. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090601
Association between mortality and persistent use of beta blockers and angiotensin-converting enzyme inhibitors in patients with left ventricular systolic dysfunction and coronary artery disease. The American journal of cardiology 20090601
Photo-induced environmental depletion processes of beta-blockers in river waters. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090601
Simultaneous RP-HPLC determination of sotalol, metoprolol, alpha-hydroxymetoprolol, paracetamol and its glucuronide and sulfate metabolites in human urine. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090601
[Therapeutic effects of amiodarone and metoprolol on chronic heart failure complicated by ventricular arrhythmia]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090601
Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090501
Nuclear targeting of FBPase in HL-1 cells is controlled by beta-1 adrenergic receptor-activated Gs protein signaling cascade. Biochimica et biophysica acta 20090501
Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction. Clinical physiology and functional imaging 20090501
Effects of metoprolol on epinephrine-induced takotsubo-like left ventricular dysfunction in non-human primates. Hypertension research : official journal of the Japanese Society of Hypertension 20090501
The effect of nebivolol treatment on oxidative stress and antioxidant status in patients with cardiac syndrome-X. Coronary artery disease 20090501
The influence of renal function on clinical outcome and response to beta-blockade in systolic heart failure: insights from Metoprolol CR/XL Randomized Intervention Trial in Chronic HF (MERIT-HF). Journal of cardiac failure 20090501
Influence of beta-blockers on the outcome of at risk patients. Minerva anestesiologica 20090501
Perioperative beta-blockade: time to change the paradigm? Acta anaesthesiologica Scandinavica 20090501
Hypertensive emergency successfully treated with metoprolol: a case report. Pediatric emergency care 20090501
Questionable benefit of perioperative beta-blockade. Journal of clinical anesthesia 20090501
[67-year-old patient with abdominal pain and pronounced peritonitis]. Deutsche medizinische Wochenschrift (1946) 20090501
Heart-cut capillary electrophoresis for drug analysis in mouse blood with electrochemical detection. Analytical biochemistry 20090415
Chromatography-tandem mass spectrometry method for the simultaneous quantitation of metoprolol succinate and simvastatin in human plasma. Journal of pharmaceutical and biomedical analysis 20090405
Safety and efficacy of a rate control protocol for cardiac CT. The British journal of radiology 20090401
Metoprolol represses PGC1alpha-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart. European journal of pharmacology 20090401
Efficient exploration of large combinatorial chemistry spaces by monomer-based similarity searching. Journal of chemical information and modeling 20090401
A pilot study on the role of autoantibody targeting the beta1-adrenergic receptor in the response to beta-blocker therapy for congestive heart failure. Journal of cardiac failure 20090401
[Beta-blockers in patients undergoing noncardiac surgery: implications of the POISE study]. Revista espanola de anestesiologia y reanimacion 20090401
Misleading ECG appearance of AV block due to concealed AV nodal conduction caused by interpolated ventricular ectopic beats. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20090401
HO-1-u-1 model for screening sublingual drug delivery--influence of pH, osmolarity and permeation enhancer. International journal of pharmaceutics 20090331
Comparison of carvedilol and metoprolol on serum lipid concentration in diabetic hypertensive patients. Diabetes, obesity & metabolism 20090301
Atenolol is inferior to metoprolol in improving left ventricular function and preventing ventricular remodeling in dogs with heart failure. Cardiology 20090301
DNA methylation might be the epigenetic molecular mechanism of different antihypertensive efficacy of metoprolol in beta1-AR gene-directed therapy. Medical hypotheses 20090301
Impact of the CYP2D6 genotype on the clinical effects of metoprolol: a prospective longitudinal study. Clinical pharmacology and therapeutics 20090301
Gene profiling of left ventricle eccentric hypertrophy in aortic regurgitation in rats: rationale for targeting the beta-adrenergic and renin-angiotensin systems. American journal of physiology. Heart and circulatory physiology 20090301
G-protein-coupled receptor kinase 4 polymorphisms and blood pressure response to metoprolol among African Americans: sex-specificity and interactions. American journal of hypertension 20090301
Fabrication of modified release tablet formulation of metoprolol succinate using hydroxypropyl methylcellulose and xanthan gum. AAPS PharmSciTech 20090301
Years-needed-to-treat to add 1 year of life: a new metric to estimate treatment effects in randomized trials. European journal of heart failure 20090301
Nebivolol decreases endothelial cell stiffness via the estrogen receptor beta: a nano-imaging study. Journal of hypertension 20090301
Echocardiographic guidance in treatment of cardiogenic shock complicating transient left ventricular apical ballooning syndrome. JACC. Cardiovascular imaging 20090301
Influence of metoprolol on systolic and diastolic function in children with heart failure. Pakistan journal of biological sciences : PJBS 20090301
The calcium channel blocker felodipine attenuates the positive hemodynamic effects of the beta-blocker metoprolol in severe dilated cardiomyopathy--a prospective, randomized, double-blind and placebo-controlled study with invasive hemodynamic assessment. International journal of cardiology 20090220
Segmental-dependent membrane permeability along the intestine following oral drug administration: Evaluation of a triple single-pass intestinal perfusion (TSPIP) approach in the rat. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215
Effect of beta blockers (metoprolol or propranolol) on effect of simvastatin in lowering C-reactive protein in acute myocardial infarction. The American journal of cardiology 20090215
The effects of aerobic fitness and beta1-adrenergic receptor blockade on cardiac work during dynamic exercise. Journal of applied physiology (Bethesda, Md. : 1985) 20090201
Normotensive sodium loading in normal man: regulation of renin secretion during beta-receptor blockade. American journal of physiology. Regulatory, integrative and comparative physiology 20090201
Normotensive sodium loading in conscious dogs: regulation of renin secretion during beta-receptor blockade. American journal of physiology. Regulatory, integrative and comparative physiology 20090201
Effects of metoprolol and diltiazem on plasma homocysteine levels in patients with isolated coronary artery ectasia. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20090201
Heart rate variability in rats with experimental chronic heart failure and long-term exposure to beta-adrenoblockers. Bulletin of experimental biology and medicine 20090201
Apical ballooning syndrome during treatment with a vascular endothelial growth factor receptor antagonist. International journal of cardiology 20090124
Micelle to solvent stacking of organic cations in capillary zone electrophoresis with electrospray ionization mass spectrometry. Journal of chromatography. A 20090109
Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation 20090106
Evaluation of injection moulding as a pharmaceutical technology to produce matrix tablets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090101
Mortality and reinfarction among patients using different beta-blockers for secondary prevention after a myocardial infarction. Cardiology 20090101
Erectile dysfunction after therapy with metoprolol: the Hawthorne effect. Cardiology 20090101
Genetic variation in the CYP2D6 gene is associated with a lower heart rate and blood pressure in beta-blocker users. Clinical pharmacology and therapeutics 20090101
The influence of Metolose structure on the free volume and the consequent metoprolol tartrate release of patches. International journal of biological macromolecules 20090101
Prevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers. Molecular and cellular biochemistry 20090101
Metoprolol succinate combination in the treatment of hypertension. Angiology 20090101
The effects of beta-adrenoceptor antagonists on proinflammatory cytokine concentrations after subarachnoid hemorrhage in rats. Anesthesia and analgesia 20090101
Inhibition of pancreatic cancer cell proliferation by propranolol occurs through apoptosis induction: the study of beta-adrenoceptor antagonist's anticancer effect in pancreatic cancer cell. Pancreas 20090101
Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure. Journal of cardiovascular pharmacology 20090101
Metoprolol succinate therapy associated with erythema multiforme. Cardiology journal 20090101
Synthesis and characterization of Zwitterionic co-polymers as matrices for sustained metoprolol tartrate delivery. Journal of biomaterials science. Polymer edition 20090101
Reversible myocardial dysfunction in a young woman with metastatic renal cell carcinoma treated with sunitinib. Acta oncologica (Stockholm, Sweden) 20090101
[Efficacy and tolerability of metoprolol retard in the treatment of patients with arterial hypertension and ischemic heart disease combined with type 2 diabetes mellitus]. Kardiologiia 20090101
Oxidation of some typical wastewater contaminants (tributyltin, clarithromycin, metoprolol and diclofenac) by ozone. Water science and technology : a journal of the International Association on Water Pollution Research 20090101
Formulation and evaluation of oral mucoadhesive multiparticulate system containing metoprolol tartarate: an in vitro-ex vivo characterization. Current drug delivery 20090101
[The use of metoprolol tartrate during restoration of sinus rhythm and its subsequent maintenance in patients with chronic atrial fibrillation]. Kardiologiia 20090101
Antihypertensive efficacy of metoprolol XL/low dose chlorthalidone (6.25 mg) combination: a randomized, comparative study in indian patients with mild-to-moderate essential hypertension. European journal of medical research 20090101
Effect of Metoprolol CR/XL on pulmonary artery pressure in chronic heart failure patients assessed by an implanted ultrasonic device with special emphasis on diurnal variation and exercise capacity. Indian heart journal 20090101
Pharmacological inhibition of the hypertensive response to combretastatin A-4 phosphate in rats. Vascular pharmacology 20090101
The acute effect of Metoprolol upon NT-proBNP level in patients with congestive heart failure. Romanian journal of internal medicine = Revue roumaine de medecine interne 20090101
Distinctive effects of carvedilol in the non-infarct zone: remodelling of the ligated rat heart linked to oxidative stress. The Journal of international medical research 20090101
Stability studies of expired tablets of metoprolol tartrate and propranolol hydrochloride. Part 1. Content determination. Acta poloniae pharmaceutica 20090101
Stability studies of expired tablets of metoprolol tartrate and propranolol hydrochloride. Part 2. Dissolution study. Acta poloniae pharmaceutica 20090101
Multiple coronary-cameral fistulae causing angina pectoris. Texas Heart Institute journal 20090101
Computed tomography for coronary anatomy and perfusion-guiding therapy in a patient with an occluded left anterior descending coronary artery. The American heart hospital journal 20090101
Transient left ventricular apical ballooning syndrome caused by abrupt metoprolol withdrawal. International journal of cardiology 20081217
CYP2D6 is a major determinant of metoprolol disposition and effects in hospitalized Russian patients treated for acute myocardial infarction. European journal of clinical pharmacology 20081201
Dissociation between cardiomyocyte function and remodeling with beta-adrenergic receptor blockade in isolated canine mitral regurgitation. American journal of physiology. Heart and circulatory physiology 20081201
Acute myocardial infarction in pregnancy. Minerva ginecologica 20081201
Dosing of beta-blocker therapy before, during, and after hospitalization for heart failure (from Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure). The American journal of cardiology 20081201
The beta2 adrenergic receptor Gln27Glu polymorphism affects insulin resistance in patients with heart failure: possible modulation by choice of beta blocker. Journal of cardiovascular pharmacology 20081201
Spatial metabolic fingerprinting using FT-IR spectroscopy: investigating abiotic stresses on Micrasterias hardyi. The Analyst 20081201
[The POISE study]. Giornale italiano di cardiologia (2006) 20081201
[Perioperative beta-blockade for reduction of cardiovascular complications in non-cardiac surgery: advantages and disadvantages]. Nederlands tijdschrift voor geneeskunde 20081129
Switching beta-blocker therapy in chronic heart failure. International journal of cardiology 20081128
Simultaneous quantification of tiloronoxim and tilorone in human urine by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081115
Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. American journal of physiology. Heart and circulatory physiology 20081101
Acute coronary syndrome presenting after pseudoephedrine use and regression with beta-blocker therapy. The Canadian journal of cardiology 20081101
Genetic polymorphisms of beta1 adrenergic receptor and their influence on the cardiovascular responses to metoprolol in a South Indian population. Journal of cardiovascular pharmacology 20081101
Effects of beta-blocker on left ventricular remodeling in rats with volume overload cardiac failure. The Journal of veterinary medical science 20081101
Should physicians initiate beta-blocker therapy in patients undergoing non-cardiac surgery? Insights from the POISE trial. Polskie Archiwum Medycyny Wewnetrznej 20081101
Metoprolol increases the expression of beta(3)-adrenoceptors in the diabetic heart: effects on nitric oxide signaling and forkhead transcription factor-3. European journal of pharmacology 20081024
Beta blockers for peripheral arterial disease. The Cochrane database of systematic reviews 20081008
Regulatory influence of melatonin on collagen accumulation in the infarcted heart scar. Journal of pineal research 20081001
Beta-blockers are safe in patients with chronic obstructive pulmonary disease, but only with caution. American journal of respiratory and critical care medicine 20081001
Extreme polyuria: at the heart of the answer. The American journal of medicine 20081001
Influence of CYP2D6*10 on the pharmacokinetics of metoprolol in healthy Korean volunteers. Journal of clinical pharmacy and therapeutics 20081001
Atrioventricular block induced by indigo carmine. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20081001
In-stent late total occlusion following left main coronary artery stenting. Acta cardiologica 20081001
Beta-blocker therapy in non-cardiac surgery. Lancet (London, England) 20080927
Beta-blocker therapy in non-cardiac surgery. Lancet (London, England) 20080927
Beta-blocker therapy in non-cardiac surgery. Lancet (London, England) 20080927
Beta-blocker therapy in non-cardiac surgery. Lancet (London, England) 20080927
Perioperative beta blockade. Lancet (London, England) 20080927
POISE trial quality control. Lancet (London, England) 20080927
Simultaneous determination of metoprolol succinate and amlodipine besylate in human plasma by liquid chromatography-tandem mass spectrometry method and its application in bioequivalence study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080915
The development of multiple probe microdialysis sampling in the stomach. Journal of pharmaceutical and biomedical analysis 20080910
New practical algorithm for modelling analyte recovery in bioanalytical reversed phase and mixed-mode solid phase extraction. Journal of pharmaceutical and biomedical analysis 20080910
The direct comparison of health and ulcerated stomach tissue: a multiple probe microdialysis sampling approach. Journal of pharmaceutical and biomedical analysis 20080910
Pilot study to assess the influence of beta-blockade on mitral regurgitant volume and left ventricular work in degenerative mitral valve disease. Circulation 20080902
Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate. European journal of clinical pharmacology 20080901
Development and in-vitro evaluation of transdermal matrix films of metoprolol tartrate. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20080901
Impact of beta-blockers on sleep in patients with mild hypertension: a randomized trial between nebivolol and metoprolol. Advances in therapy 20080901
Efficacy of carvedilol for ischemia/reperfusion-induced oxidative renal injury in rats. Transplantation proceedings 20080901
Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. Journal of the American College of Cardiology 20080819
Effect of PCI on quality of life in patients with stable coronary disease. The New England journal of medicine 20080814
Noradrenergic modulation of subthalamic nucleus activity in human: metoprolol reduces spiking activity in microelectrode recordings during deep brain stimulation surgery for Parkinson's disease. Acta neurochirurgica 20080801
Enantiomeric separation by using nano-liquid chromatography with on-column focusing. Journal of separation science 20080801
Intracellular mechanisms of specific beta-adrenoceptor antagonists involved in improved cardiac function and survival in a genetic model of heart failure. Journal of molecular and cellular cardiology 20080801
Takotsubo cardiomyopathy in pregnancy. Obstetrics and gynecology 20080801
Combination prophylactic therapy for post-operative atrial fibrillation. Journal of the American College of Cardiology 20080729
Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. European journal of pharmacology 20080728
Evaluation of monolithic packed 96-tips and liquid chromatography-tandem mass spectrometry for extraction and quantification of pindolol and metoprolol in human plasma samples. Journal of chromatography. A 20080704
Drug permeability across a phospholipid vesicle-based barrier 4. The effect of tensides, co-solvents and pH changes on barrier integrity and on drug permeability. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080703
A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080701
Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart. Cardiovascular research 20080701
Simultaneous determination of beta-blockers in human plasma using liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC 20080701
Differential role of calcium/calmodulin-dependent protein kinase II in desflurane-induced preconditioning and cardioprotection by metoprolol: metoprolol blocks desflurane-induced preconditioning. Anesthesiology 20080701
[Effects of metoprolol on perioperative cardiovascular events in patients with risk or at high risk for coronary artery disease undergoing non-cardiac surgery]. Zhonghua yi xue za zhi 20080603
Nebivolol, but not metoprolol, improves endothelial function of the corpus cavernosum in apolipoprotein e-knockout mice. The Journal of pharmacology and experimental therapeutics 20080601
Effects of imatinib (Glivec) on the pharmacokinetics of metoprolol, a CYP2D6 substrate, in Chinese patients with chronic myelogenous leukaemia. British journal of clinical pharmacology 20080601
Carvedilol versus controlled-release metoprolol for elderly veterans with heart failure. Journal of the American Geriatrics Society 20080601
Simultaneous separation of eight beta-adrenergic drugs using titanium dioxide nanoparticles as additive in capillary electrophoresis. Electrophoresis 20080601
In vitro and in vivo pharmacodynamic properties of metoprolol in fructose-fed hypertensive rats. Journal of cardiovascular pharmacology 20080601
The comparative effects of metoprolol and perindopril on aortic elasticity in young patients with prehypertension. Blood pressure monitoring 20080601
Precipitation of ventricular fibrillation by intravenous diltiazem and metoprolol in a young patient with occult Wolff-Parkinson-White syndrome. Pacing and clinical electrophysiology : PACE 20080601
Cardiogenic shock following nasal septoplasty: a case report and review of the literature. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20080601
The effect of metoprolol on perioperative outcome in coronary patients undergoing nonvascular abdominal surgery. Journal of clinical anesthesia 20080601
Perioperative beta blockade: where do we go from here? Lancet (London, England) 20080531
Effects of extended-release metoprolol succinate in patients undergoing non-cardiac surgery (POISE trial): a randomised controlled trial. Lancet (London, England) 20080531
Role of beta1-adrenoceptor in the basolateral amygdala of rats with anxiety-like behavior. Brain research 20080523
Sympathetic activation causes focal adhesion signaling alteration in early compensated volume overload attributable to isolated mitral regurgitation in the dog. Circulation research 20080509
Comparison of the efficacy of metoprolol and carvedilol for preventing atrial fibrillation after coronary bypass surgery. International journal of cardiology 20080507
Cryo-irradiation as a terminal method for the sterilization of drug aqueous solutions. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080501
Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. The Journal of pharmacology and experimental therapeutics 20080501
Acute beta-adrenergic blockade: an unusual cause of suppression of spectral entropy values during isoflurane anaesthesia. Acta anaesthesiologica Scandinavica 20080501
Comparison of rate and rhythm control in hypertension patients with atrial fibrillation. Circulation journal : official journal of the Japanese Circulation Society 20080501
Complete atrioventricular block associated with concomitant use of metoprolol and paroxetine. Mayo Clinic proceedings 20080501
Efficacy of pre-scan beta-blockade and impact of heart rate on image quality in patients undergoing coronary multidetector computed tomography angiography. European journal of radiology 20080401
Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat. American journal of physiology. Heart and circulatory physiology 20080401
Sex differences to myocardial ischemia and beta-adrenergic receptor blockade in conscious rats. American journal of physiology. Heart and circulatory physiology 20080401
Quantitative evaluation of ontogenetic change in heart rate and its autonomic regulation in newborn mice with the use of a noninvasive piezoelectric sensor. American journal of physiology. Heart and circulatory physiology 20080401
Benefits of long-term beta-blockade in experimental chronic aortic regurgitation. American journal of physiology. Heart and circulatory physiology 20080401
Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401
Perioperative myocardial infarction after cesarean section in a young woman with hypertrophic obstructive cardiomyopathy. Acta anaesthesiologica Scandinavica 20080401
A physician with pounding headaches. Blood pressure monitoring 20080401
Stability of metoprolol tartrate injection 1 mg/mL undiluted and 0.5 mg/mL in 0.9% sodium chloride injection and 5% dextrose injection. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080401
Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents. Medical science monitor : international medical journal of experimental and clinical research 20080401
S-metoprolol: the 2008 clinical review. Journal of the Indian Medical Association 20080401
Major differences in gene expression in human coronary smooth muscle cells after nebivolol or metoprolol treatment. International journal of cardiology 20080328
Beneficial effect of the central nervous system beta-adrenoceptor blockade on the failing heart. Circulation research 20080328
Labetalol facilitates GABAergic transmission to rat periaqueductal gray neurons via antagonizing beta1-adrenergic receptors--a possible mechanism underlying labetalol-induced analgesia. Brain research 20080310
Inhibition of metoprolol metabolism and potentiation of its effects by paroxetine in routinely treated patients with acute myocardial infarction (AMI). European journal of clinical pharmacology 20080301
Differential effects of carvedilol and metoprolol succinate on plasma norepinephrine release and peak exercise heart rate in subjects with chronic heart failure. Journal of cardiovascular pharmacology and therapeutics 20080301
Comparison of the effects of carvedilol and metoprolol on exercise ventilatory efficiency in patients with congestive heart failure. Circulation journal : official journal of the Japanese Circulation Society 20080301
Chronic kidney disease--a disease domain complex. Geriatrics 20080301
Carvedilol is more effective than metoprolol in preventing atrial fibrillation (AF) after coronary artery bypass. Heart rhythm 20080301
Simultaneous determination of metoprolol succinate and amlodipine besylate in pharmaceutical dosage form by HPLC. Journal of pharmaceutical and biomedical analysis 20080213
Hypothalamic angiotensinergic-noradrenergic systems interaction in fructose induced hypertension. Regulatory peptides 20080207
Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080201
Renal and cardiac effects of antihypertensive treatment with ramipril versus metoprolol in autosomal dominant polycystic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080201
Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress. Journal of molecular and cellular cardiology 20080201
Increased anesthetic depth, not metoprolol, may have caused the change in bispectral index. Anesthesia and analgesia 20080201
Effect of nebivolol and metoprolol treatments on serum asymmetric dimethlyarginine levels in hypertensive patients with type 2 diabetes mellitus. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20080201
Comparative efficacy of two different beta-blockers on 24-hour blood pressure control. Journal of clinical hypertension (Greenwich, Conn.) 20080201
Effect of beta-blockers on endothelial function during biological aging: a nanotechnological approach. Journal of cardiovascular pharmacology 20080201
[Termination of atrio-ventricular reentrant tachycardia in a pregnant woman using transoesophageal atrial pacing and pharmacotherapy]. Kardiologia polska 20080201
Changes in beta 2-adrenoceptor and other signaling proteins produced by chronic administration of 'beta-blockers' in a murine asthma model. Pulmonary pharmacology & therapeutics 20080101
Three drug indications for patients with peripheral arterial disease bite the dust: report from the American Heart Association meeting 2007 in Orlando. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20080101
Improvement of cardiac diastolic function by long-term centrally mediated sympathetic inhibition in one-kidney, one-clip hypertensive rabbits. American journal of hypertension 20080101
Treatment with metoprolol succinate, a selective beta adrenergic blocker, lowers blood pressure without altering insulin sensitivity in diabetic patients. Journal of clinical hypertension (Greenwich, Conn.) 20080101
Clinical trials update from the American Heart Association 2007: CORONA, RethinQ, MASCOT, AF-CHF, HART, MASTER, POISE and stem cell therapy. European journal of heart failure 20080101
Nebivolol and metoprolol for treating migraine: an advance on beta-blocker treatment? Headache 20080101
Protective effects of carvedilol in murine model with the coxsackievirus B3-induced viral myocarditis. Journal of cardiovascular pharmacology 20080101
Differential index: a simple time domain heart rate variability analysis with prognostic implications in stable angina pectoris. Cardiology 20080101
Evaluation of the effectiveness of oral Beta-blockade in patients for coronary computed tomographic angiography. Journal of computer assisted tomography 20080101
Beta-blockers have a beneficial effect upon endothelial function and microalbuminuria in African-American subjects with diabetes and hypertension. Journal of diabetes and its complications 20080101
[Effect of antihypertensive agents from various pharmacological groups on blood pressure reaction during stress-testing. Part I. Comparative characteristics of medications, exerting effect of sympathoadrenal block]. Kardiologiia 20080101
[Controlled release metoprolol succinate in MERIT-HF. Analysis of patients subgroups]. Kardiologiia 20080101
Both clonidine and metoprolol modify anesthetic depth indicators and reduce intraoperative propofol requirement. Journal of anesthesia 20080101
Interaction between different doses of simvastatin after two-week administration and metoprolol injection on the heart rate in normocholesterolemic rats. Acta poloniae pharmaceutica 20080101
Dose-dependent influence of two-week administration of simvastatin and metoprolol injection on the blood pressure in normocholesterolemic rats. Acta poloniae pharmaceutica 20080101
[The role of beta-adrenoblockers and If-inhibitor ivabradine in lowering of rate of development of cardiac complications after carotid endarterectomy]. Kardiologiia 20080101
Preoperative prophylaxis can decrease rates of atrial fibrillation in open heart surgery: a retrospective study. The heart surgery forum 20080101
Is there still a role for treatment with beta-adrenoceptor antagonists in post-myocardial infarction patients with well-preserved left ventricular systolic function? Acute cardiac care 20080101
Late-life somnambulism after therapy with metoprolol. Clinical neuropharmacology 20080101
Combined milrinone and enteral metoprolol therapy in patients with septic myocardial depression. Critical care (London, England) 20080101
Spectrophotometric and column high-performance liquid chromatographic methods for simultaneous estimation of metoprolol tartrate and hydrochlorothiazide in tablets. Journal of AOAC International 20080101
[Efficacy and safety of metoprolol CR/XL: confidence based on proofs]. Kardiologiia 20080101
Demographic analyses of the effects of carvedilol vs metoprolol on glycemic control and insulin sensitivity in patients with type 2 diabetes and hypertension in the Glycemic Effects in Diabetes Mellitus: Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) study. Journal of the cardiometabolic syndrome 20080101
Sinoatrial arrest associated with Takotsubo cardiomyopathy. Congestive heart failure (Greenwich, Conn.) 20080101
Effects of polymorphism of the beta(1) adrenoreceptor and CYP2D6 on the therapeutic effects of metoprolol. The Journal of international medical research 20080101
[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction]. Zhonghua xin xue guan bing za zhi 20080101
[Comparison of metoprolol vs clonazepam as a first treatment choice among patients with neurocardiogenic syncope]. Gaceta medica de Mexico 20080101
[Atenolol and metoprolol differentiated therapy of patients with arterial hypertension complicated by pathology of the digestive tract organs]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101
[The role of reflexotherapy and physical training in the combined treatment and the prevention of paroxysmal form of idiopathic atrial fibrillation]. Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20080101
Lightning induced atrial fibrillation. Kathmandu University medical journal (KUMJ) 20080101
[Effects of Verapamil and Metoprolol on heart rate variability in patients with coronary heart disease]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20071218
[Efficacy, safety and tolerance of Felodipine controlled release tablets and Felodipine controlled release tablets associated combination therapy in the treatment of mild to moderate essential hypertension in China]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20071218
Aristolochic Acid induces heart failure in zebrafish embryos that is mediated by inflammation. Toxicological sciences : an official journal of the Society of Toxicology 20071201
Hospitalization rates of generic metoprolol compared with the original beta-blocker in an epidemiological database study. Pharmacoepidemiology and drug safety 20071201
Switching to once-daily evidence-based [beta]-blockers in patients with systolic heart failure or left ventricular dysfunction after myocardial infarction. Critical care nurse 20071201
Recent findings into the potential of gene therapy to reverse heart failure. Expert opinion on biological therapy 20071201
Too many zeros in metoprolol. The Journal of pediatrics 20071201
Effect of nebivolol and metoprolol treatments on serum asymmetric dimethylarginine levels in hypertensive patients with type 2 diabetes mellitus. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20071201
Death temporally related to the use of a Beta adrenergic receptor antagonist in cocaine associated myocardial infarction. Journal of medical toxicology : official journal of the American College of Medical Toxicology 20071201
Psoriasis aggravation and metoprolol treatment -- a prospective observational case study. International journal of clinical pharmacology and therapeutics 20071201
Cardiovascular toxicity due to metoprolol poisoning in a patient with coronary artery disease. British journal of clinical pharmacology 20071101
Binding of betaxolol, metoprolol and oligonucleotides to synthetic and bovine ocular melanin, and prediction of drug binding to melanin in human choroid-retinal pigment epithelium. Pharmaceutical research 20071101
Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney disease. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071101
Effect of carvedilol and metoprolol on the mode of death in patients with heart failure. European journal of heart failure 20071101
[Beta-adrenoceptor antagonists and ACE-inhibitors. Carvedilol compared with metoprolol as combination partner in cases of diabetes and hypertension]. Deutsche medizinische Wochenschrift (1946) 20071101
Dose conversions: opportunity for error. The American journal of medicine 20071101
Lowering blood pressure with beta-blockers in combination with other renin-angiotensin system blockers in patients with hypertension and type 2 diabetes: results from the GEMINI Trial. Journal of clinical hypertension (Greenwich, Conn.) 20071101
[Preparation of transdermal drug delivery system of felodipine-metoprolol and its bioavailability in rabbits]. Yao xue xue bao = Acta pharmaceutica Sinica 20071101
The function of left ventricular basal segments is most important for long-term recovery. International journal of cardiology 20071018
[Effect of chronic myocardial infarction on the distribution of beta-adrenoceptors in heart: experiment with dogs]. Zhonghua yi xue za zhi 20071016
Liquid chromatography tandem mass spectrometry method for simultaneous determination of metoprolol tartrate and ramipril in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
Effects of metoprolol on beta1 adrenergic receptor polymorphism and receptor density in urban Chinese patients with heart failure. Chinese medical journal 20071005
Effect of beta-blocker therapy on left atrial function in patients with heart failure: comparison of metoprolol succinate with carvedilol. The international journal of cardiovascular imaging 20071001
Hypersensitivity myocarditis induced by beta-blockers: an unexpected cause of abrupt deterioration in hypertrophic cardiomyopathy. Intensive care medicine 20071001
The influence of formulation factors on the kinetic release of metoprolol tartrate from prolong release coated minitablets. Drug development and industrial pharmacy 20071001
Transient left ventricular dysfunction due to stress-induced cardiomyopathy. Arquivos brasileiros de cardiologia 20071001
Antihypertensive therapy in a patient with type B and de novo type A aortic dissection: case study. Critical care clinics 20071001
Hymenoptera sting-induced Kounis syndrome: effects of aspirin and beta-blocker administration. International journal of cardiology 20070914
An investigation into the influence of drug lipophilicity on the in vivo absorption profiles from subcutaneous microspheres and in situ forming depots. Journal of controlled release : official journal of the Controlled Release Society 20070911
Thermodynamic characterization of separations on alkaline-stable silica-based C18 columns: why basic solutes may have better capacity and peak performance at higher pH. Journal of chromatography. A 20070907
Effects of metoprolol treatment on a disintegrin metalloproteinase expression and extracellular matrix remodeling after myocardial infarction in rats. Chinese medical journal 20070905
Correlation between the permeability of metoprolol tartrate through plasticized isolated ethylcellulose/hydroxypropyl methylcellulose films and drug release from reservoir pellets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070901
Porous hydroxyapatite tablets as carriers for low-dosed drugs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070901
Dynamic blood pressure control and middle cerebral artery mean blood velocity variability at rest and during exercise in humans. Acta physiologica (Oxford, England) 20070901
Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation. American journal of physiology. Heart and circulatory physiology 20070901
Should beta-blocker therapy be reduced or withdrawn after an episode of decompensated heart failure? Results from COMET. European journal of heart failure 20070901
Divergence of hypertrophic growth and fetal gene profile: the influence of beta-blockers. British journal of pharmacology 20070901
Central mechanisms of controlled-release metoprolol in migraine: a double-blind, placebo-controlled study. Cephalalgia : an international journal of headache 20070901
Does metoprolol inhibit the cortical spreading depression? Acute effects of systematic metropol on CSD in rats. Cephalalgia : an international journal of headache 20070901
Optimal beta-blocker for prevention of atrial fibrillation after on-pump coronary artery bypass graft surgery: carvedilol versus metoprolol. Heart rhythm 20070901
Beta-blocker treatment in an adolescent with amitriptyline intoxication. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20070901
Effect of beta-adrenergic and renin-angiotensin system blockade on myocyte apoptosis and oxidative stress in diabetic hypertensive rats. Life sciences 20070901
Investigation of hypromellose particle size effects on drug release from sustained release hydrophilic matrix tablets. Drug development and industrial pharmacy 20070901
Resting heart rate in cardiovascular disease. Journal of the American College of Cardiology 20070828
Baroreflex dysfunction in rats submitted to protein restriction. Life sciences 20070823
Comparative effectiveness of beta-adrenergic antagonists (atenolol, metoprolol tartrate, carvedilol) on the risk of rehospitalization in adults with heart failure. The American journal of cardiology 20070815
Effects of metoprolol and carvedilol on pre-existing and new onset diabetes in patients with chronic heart failure: data from the Carvedilol Or Metoprolol European Trial (COMET). Heart (British Cardiac Society) 20070801
Time-of-day variation in cardiovascular response to maximal exercise testing in coronary heart disease patients taking a beta-blocker. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20070801
Rapid decrease in bispectral index following a single intravenous injection of metoprolol. Anesthesia and analgesia 20070801
Carvedilol increases copper-zinc superoxide dismutase activity in patients with acute myocardial infarction. Basic & clinical pharmacology & toxicology 20070801
Delayed onset of malignant hyperthermia without creatine kinase elevation in a geriatric, ryanodine receptor type 1 gene compound heterozygous patient. Anesthesiology 20070801
Prevention of ventricular fibrillation requires central beta-adrenoceptor blockade in rabbits. Scandinavian cardiovascular journal : SCJ 20070801
Prognostic importance of plasma NT-pro BNP in chronic heart failure in patients treated with a beta-blocker: results from the Carvedilol Or Metoprolol European Trial (COMET) trial. European journal of heart failure 20070801
Adsorption of beta blockers to environmental surfaces. Environmental science & technology 20070801
Comparative evaluation of atenolol and metoprolol on cardiovascular complications associated with streptozotocin-induced diabetic rats. Canadian journal of physiology and pharmacology 20070801
My wife suffers from atrial fibrillation. She is on warfarin, digoxin and metoprolol. She still gets the occasional mild attack. Is this normal? Heart advisor 20070801
Dynamic left ventricular outflow tract obstruction in acute myocardial infarction with shock: cause, effect, and coincidence. Circulation 20070731
Effect of beta-adrenoceptors on the behaviour induced by the neuropeptide glutamic acid isoleucine amide. European journal of pharmacology 20070730
Use of corticosteroids to prevent atrial fibrillation after cardiac surgery. JAMA 20070718
Metoprolol reverses left ventricular remodeling in patients with asymptomatic systolic dysfunction: the REversal of VEntricular Remodeling with Toprol-XL (REVERT) trial. Circulation 20070703
Chronic treatment with carvedilol improves Ca(2+)-dependent ATP consumption in triton X-skinned fiber preparations of human myocardium. The Journal of pharmacology and experimental therapeutics 20070701
Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI. Diabetic medicine : a journal of the British Diabetic Association 20070701
In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism. Naunyn-Schmiedeberg's archives of pharmacology 20070701
Randomized active-controlled study comparing effects of treatment with carvedilol versus metoprolol in patients with left ventricular dysfunction after acute myocardial infarction. American heart journal 20070701
Effects of carvedilol versus metoprolol on endothelial function and oxidative stress in patients with type 2 diabetes mellitus. American journal of hypertension 20070701
Biotransformation of metoprolol by the fungus Cunninghamella blakesleeana. Acta pharmacologica Sinica 20070701
Body weight changes with beta-blocker use: results from GEMINI. The American journal of medicine 20070701
Metoprolol does not effect myocardial fractional flow reserve in patients with intermediate coronary stenoses. International heart journal 20070701
Metoprolol-induced hyperkalaemia in chronic respiratory acidosis. The New Zealand medical journal 20070629
Supercritical fluid chromatography of metoprolol and analogues on aminopropyl and ethylpyridine silica without any additives. Journal of chromatography. A 20070622
Early metoprolol administration before coronary reperfusion results in increased myocardial salvage: analysis of ischemic myocardium at risk using cardiac magnetic resonance. Circulation 20070612
Clinical reminders attached to echocardiography reports of patients with reduced left ventricular ejection fraction increase use of beta-blockers: a randomized trial. Circulation 20070605
Maintenance of sinus rhythm with metoprolol CR initiated before cardioversion and repeated cardioversion of atrial fibrillation: a randomized double-blind placebo-controlled study. European heart journal 20070601
Two-chiral-component microemulsion electrokinetic chromatography-chiral surfactant and chiral oil: part 1. dibutyl tartrate. Electrophoresis 20070601
Preoperative beta-blocker use reduces atrial fibrillation in off-pump coronary bypass surgery. ANZ journal of surgery 20070601
Valsartan versus lisinopril or extended-release metoprolol in preventing cardiovascular and renal events in patients with hypertension. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070601
Artemisinin antimalarials moderately affect cytochrome P450 enzyme activity in healthy subjects. Fundamental & clinical pharmacology 20070601
Effect of metoprolol on heart rate variability in symptomatic patients with mitral valve prolapse. The American journal of cardiology 20070601
Association of beta-blocker dose with serum procollagen concentrations and cardiac response to spironolactone in patients with heart failure. Pharmacotherapy 20070601
Rational pharmacoeconomics? The New Zealand medical journal 20070601
The safety of amiodarone in patients with heart failure. Journal of cardiac failure 20070601
Effects of beta-blocker therapy on high sensitivity c-reactive protein, oxidative stress, and cardiac function in patients with congestive heart failure. Journal of cardiac failure 20070601
Metoprolol succinate extended release/hydrochlorothiazide combination tablets. Vascular health and risk management 20070601
Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. Journal of the American College of Cardiology 20070529
[Beta blockers: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects]. Nihon rinsho. Japanese journal of clinical medicine 20070528
[Hemodynamic changes during head-up tilt test and predictive value thereof in predicting the efficacy of metoprolol therapy in children with vasovagal syncope]. Zhonghua yi xue za zhi 20070515
Effects of prolonged metoprolol treatment on neural remodeling and inducible ventricular arrhythmias after myocardial infarction in rabbits. International journal of cardiology 20070502
Bradycardic therapy improves left ventricular function and remodeling in dogs with coronary embolization-induced chronic heart failure. The Journal of pharmacology and experimental therapeutics 20070501
Meningococcal disease associated with an acute post-streptococcal complement deficiency. Pediatric nephrology (Berlin, Germany) 20070501
Does coronary artery bypass surgery affect metoprolol bioavailability. European journal of clinical pharmacology 20070501
beta-blocker use and diabetes symptom score: results from the GEMINI study. Diabetes, obesity & metabolism 20070501
High-quality randomized trial of perioperative beta-blockade. American heart journal 20070501
Process analytical technology: chemometric analysis of Raman and near infra-red spectroscopic data for predicting physical properties of extended release matrix tablets. Journal of pharmaceutical sciences 20070501
Tolerability of beta-blockers in outpatients with refractory heart failure who were receiving continuous milrinone. Pharmacotherapy 20070501
Comparative clinical study of the efficacy and safety of a S-metoprolol ER tablet versus a racemate metoprolol ER tablet in patients with chronic stable angina. International journal of clinical pharmacology and therapeutics 20070501
[Effects of metoprolol on cardiac function and myocyte calcium regulatory protein expressions in rabbits with experimental heart failure]. Zhonghua xin xue guan bing za zhi 20070501
Effect of beta-adrenoceptor blockers on growth of neurites in spinal ganglia in organotypic tissue culture. Bulletin of experimental biology and medicine 20070501
[COMET: metoprolol]. Nihon rinsho. Japanese journal of clinical medicine 20070428
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study. Circulation 20070417
Mixture models and subpopulation classification: a pharmacokinetic simulation study and application to metoprolol CYP2D6 phenotype. Journal of pharmacokinetics and pharmacodynamics 20070401
Does beta-blocker treatment influence central sleep apnoea? Respiratory medicine 20070401
Elimination of beta-blockers in sewage treatment plants. Water research 20070401
Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men. Clinical and experimental pharmacology & physiology 20070401
A convenient method for local drug administration at predefined sites in the entire gastrointestinal tract: experiences from 13 phase I studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070401
Semipermanent capillary coatings in mixed organic-water solvents for CE. Electrophoresis 20070401
Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome. Nephrology (Carlton, Vic.) 20070401
Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure. Cardiovascular drugs and therapy 20070401
Multi-arterial myocardial bridge: uncommon clinical and anatomical presentations. Arquivos brasileiros de cardiologia 20070401
Compliance, clinical outcome, and quality of life of patients with stable angina pectoris receiving once-daily betaxolol versus twice daily metoprolol: a randomized controlled trial. Vascular health and risk management 20070401
Arrhythmogenic right ventricular dysplasia:clinical study. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20070401
Effects of nebivolol on platelet activation in hypertensive patients: a comparative study with metoprolol. International journal of cardiology 20070320
[Beta blockers in hypertension treatment Will stepping back come soon?]. MMW Fortschritte der Medizin 20070315
Carvedilol protects better against vascular events than metoprolol in heart failure: results from COMET. Journal of the American College of Cardiology 20070306
Plasma concentration of Fas/Fas ligand and left ventricular function in response to metoprolol in conjunction with standard treatment. Clinical science (London, England : 1979) 20070301
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301
Changes in the in vitro pharmacodynamic properties of metoprolol in atria isolated from spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology 20070301
Sodium-hydrogen exchange inhibition and beta-blockade additively decrease infarct size. The Annals of thoracic surgery 20070301
Invited commentary. The Annals of thoracic surgery 20070301
Effect of beta blockers (carvedilol or metoprolol XL) in patients with transposition of great arteries and dysfunction of the systemic right ventricle. The American journal of cardiology 20070301
Pharmacokinetics and hepatic extraction of metoprolol in rats with glycerol-induced acute renal failure. Biological & pharmaceutical bulletin 20070301
Effect of diltiazem and metoprolol on left atrial appendix functions in patients with nonvalvular chronic atrial fibrillation. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20070301
Safety of a postoperative beta-blocker infusion protocol for nonmonitored units in a community hospital. Connecticut medicine 20070301
Application of sucrose fatty acid esters in transdermal therapeutic systems. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070201
Metoprolol treatment decreases tissue myeloperoxidase activity after spinal cord injury in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20070201
Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio). Analytical and bioanalytical chemistry 20070201
Comparison of duloxetine, escitalopram, and sertraline effects on cytochrome P450 2D6 function in healthy volunteers. Journal of clinical psychopharmacology 20070201
Is there a role for beta-adrenergic blockers in treating hypertension in children? The Journal of pediatrics 20070201
Efficacy and safety of extended release metoprolol succinate in hypertensive children 6 to 16 years of age: a clinical trial experience. The Journal of pediatrics 20070201
A population-based analysis of the class effect of beta-blockers after myocardial infarction. American heart journal 20070201
Protocol implementation in anesthesia: beta-blockade in non-cardiac surgery patients. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20070201
Determination of atenolol and metoprolol by capillary electrophoresis with tris(2,2'-bipyridyl)ruthenium(ii) electrochemiluminescence detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20070201
Acute hemodynamic effects of moderate doses of nebivolol versus metoprolol in patients with systolic heart failure. International journal of clinical pharmacology and therapeutics 20070201
Assessment of left ventricular function and mass in patients undergoing computed tomography (CT) coronary angiography using 64-detector-row CT: comparison to magnetic resonance imaging. Acta radiologica (Stockholm, Sweden : 1987) 20070201
Kinetics and degradation products for direct photolysis of beta-blockers in water. Environmental science & technology 20070201
Left ventricular volume and function in cynomolgus monkeys using real-time three-dimensional echocardiography. Journal of medical primatology 20070201
Carvedilol in the treatment of chronic heart failure: lessons from the Carvedilol Or Metoprolol European Trial. Vascular health and risk management 20070201
Functional analysis of endogenous beta-adrenergic receptor through fluorimetric monitoring of cyclic nucleotide-gated ion channel. Analytical biochemistry 20070115
The Influence of prolonged beta-blockers treatment on male rabbit's sexual behavior and penile microcirculation. International journal of impotence research 20070101
A modern view of excipient effects on bioequivalence: case study of sorbitol. Pharmaceutical research 20070101
Effects of metoprolol on sympathetic remodeling and electrical remodeling at infarcted border zone after myocardial infarction in rabbits. Cardiology 20070101
Carvedilol: use in chronic heart failure. Expert review of cardiovascular therapy 20070101
Sustained release of highly water-soluble drugs with micelle forming ability from polyionic matrix tablets. Die Pharmazie 20070101
Beta blockers for congestive heart failure. Acta medica Indonesiana 20070101
Influence of nebivolol and metoprolol on inflammatory mediators in human coronary endothelial or smooth muscle cells. Effects on neointima formation after balloon denudation in carotid arteries of rats treated with nebivolol. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101
[Study of carvedilol on plaque stability in carotid atherosclerotic rabbits transfected by p53 gene]. Zhonghua xin xue guan bing za zhi 20070101
Pronounced improvement in systolic and diastolic ventricular long axis function after treatment with metoprolol. European journal of heart failure 20070101
Beta-blockers in 2007? Cardiovascular journal of Africa 20070101
Acute coronary syndrome: short-term effects of early intravenous metoprolol on maximum P wave duration and P wave dispersion. Advances in therapy 20070101
The influence of beta-blockers on delayed memory function in people with cognitive impairment. American journal of Alzheimer's disease and other dementias 20070101
Indapamide decreases plasma adiponectin concentration in patients with essential hypertension. Kidney & blood pressure research 20070101
[Assessment of dynamics of the autonomic cardiovascular system regulation based on low-frequency rhythm synchronization in patients with ischemic heart diseases complicated by myocardial infarction treated with metoprolol]. Terapevticheskii arkhiv 20070101
Mimicry of phase I drug metabolism--novel methods for metabolite characterization and synthesis. Rapid communications in mass spectrometry : RCM 20070101
[The effects of beta-adrenoblocker therapy on the physical working capacity of patients with chronic heart failure of various origin]. Klinicheskaia meditsina 20070101
Beta-2-adrenergic receptor polymorphisms and changes in lipids induced by metoprolol. Pharmacology 20070101
Comparative bioavailability of metoprolol tartrate after oral and transdermal administration in healthy male volunteers. Clinical drug investigation 20070101
[Administration of cardioselective beta-adrenoblockers in patients with arterial hypertension and/or ischemic heart disease associated with bronchoobstructive syndrome]. Terapevticheskii arkhiv 20070101
[Pharmacokinetics of enalapril and metoprolol in hypertensive patients with hepatic pathology]. Terapevticheskii arkhiv 20070101
[New facts about pathogenesis of atrial fibrillation: correlation between changes in bioelectric brain activity and recurrence of atrial fibrillation paroxysms]. Terapevticheskii arkhiv 20070101
[The effect of medicamentous and non-medicamentous therapy on lowering risk factors for cardiovascular and cerebrovascular episodes in an interventional study]. Srpski arhiv za celokupno lekarstvo 20070101
[beta-Adrenoblockers in cardiology: metoprolol succinate]. Kardiologiia 20070101
[Correction of portal hypertension by beta-adrenoblockers (atenolol and metoprolol) and inhibitors of ACE (lisinopril and enalapril) in liver cirrhosis]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20070101
Simultaneous analysis of tramadol, metoprolol and their metabolites in human plasma and urine by high performance liquid chromatography. Chinese medical journal 20061205
Reactions of the amine-containing drugs fluoxetine and metoprolol during chlorination and dechlorination processes used in wastewater treatment. Chemosphere 20061201
Comparison of a beta-blocker and an If current inhibitor in rabbits with myocardial infarction. The Journal of cardiovascular surgery 20061201
A comparison of the trough-to-peak ratio of cardio-selective beta-blockers in patients with newly diagnosed hypertension. Blood pressure monitoring 20061201
Prognostic implications of renal dysfunction in patients with stable angina pectoris. Journal of internal medicine 20061201
Methamphetamine abuse. The American journal of nursing 20061201
Retinopathy and choroidopathy as the initial signs of hypertensive brainstem encephalopathy. Archives of ophthalmology (Chicago, Ill. : 1960) 20061201
Factorial antihypertensive study of an extended-release metoprolol and hydrochlorothiazide combination. American journal of hypertension 20061201
Coronary angioplasty induced oxidative stress and its relation with metoprolol use and plasma homocysteine levels. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20061201
Direct effects of 3 combinations of enalapril, metoprolol, and spironolactone on cardiac remodeling in dilated cardiomyopathic hamsters. Journal of cardiac failure 20061201
Comparative ecotoxicological hazard assessment of beta-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach. Environmental science & technology 20061201
Use of telemedicine in the diagnosis of paroxysmal atrial fibrillation and to monitor the effect of antiarrhythmic drug therapy. Herzschrittmachertherapie & Elektrophysiologie 20061201
Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. Drug metabolism and pharmacokinetics 20061201
[Fosinopril but not metoprolol attenuated the increased matrix metallo-proteinases 9 expression at mRNA and protein levels of human umbilical vein endothelial cells exposed to oscillatory flow]. Zhonghua xin xue guan bing za zhi 20061201
Ion-pair supercritical fluid chromatography of metoprolol and related amino alcohols on diol silica. Journal of chromatography. A 20061117
Enhanced isoproterenol-induced cardiac hypertrophy in transgenic rats with low brain angiotensinogen. American journal of physiology. Heart and circulatory physiology 20061101
Lipid composition effect on permeability across PAMPA. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101
Site of drug absorption after oral administration: assessment of membrane permeability and luminal concentration of drugs in each segment of gastrointestinal tract. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20061101
Differential associations of beta-blockers with hemorrhagic events for chronic heart failure patients on warfarin. Pharmacoepidemiology and drug safety 20061101
Differing effects of metoprolol and propranolol on large vessel and microvessel responsiveness in a porcine model of coronary spasm. Coronary artery disease 20061101
Fluorescence determination of metoprolol in human plasma by trilinear decomposition-based calibration techniques. Analytical and bioanalytical chemistry 20061101
Ion pair-mediated transport of metoprolol across a three lipid-component PAMPA system. Journal of controlled release : official journal of the Controlled Release Society 20061101
The effects of perioperative beta-blockade: results of the Metoprolol after Vascular Surgery (MaVS) study, a randomized controlled trial. American heart journal 20061101
Tolerability of beta-blockers metabolized via cytochrome P450 2D6 is sex-dependent. Clinical pharmacology and therapeutics 20061101
In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions. The Journal of pharmacy and pharmacology 20061101
Stereoisomer quantification of the beta-blocker drugs atenolol, metoprolol, and propranolol in wastewaters by chiral high-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A 20061027
Drugs acting as plasticizers in polymeric systems: a quantitative treatment. Journal of controlled release : official journal of the Controlled Release Society 20061027
Thoracic epidural analgesia and antihypertensive therapy: a matter of timing? European journal of anaesthesiology 20061001
Lessons from the African-American Study of Kidney Disease and Hypertension: an update. Current hypertension reports 20061001
Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method. Journal of pharmaceutical and biomedical analysis 20060926
Attenuation of the negative inotropic effects of metoprolol at short cycle lengths in humans: comparison with sotalol and verapamil. Journal of the American College of Cardiology 20060919
Can statins reduce perioperative morbidity and mortality in patients undergoing non-cardiac vascular surgery? European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20060901
Autoantibody against beta1-adrenergic receptor and left ventricular remodeling changes in response to metoprolol treatment. European journal of clinical investigation 20060901
Discordant beta-blocker effects on clinic, ambulatory, resting, and exercise hemodynamics in patients with hypertension. Pharmacotherapy 20060901
Effect of age on vascular beta2-adrenergic receptor desensitization is not mediated by the receptor coupling to Galphai proteins. The journals of gerontology. Series A, Biological sciences and medical sciences 20060901
Vasovagal syncope misdiagnosed as epilepsy for 17 years: prime importance of clinical history. Epileptic disorders : international epilepsy journal with videotape 20060901
Valdecoxib does not interfere with the CYP2D6 substrate metoprolol. International journal of clinical pharmacology and therapeutics 20060901
Effects of metoprolol tartrate therapy in patients with heart failure. Arquivos brasileiros de cardiologia 20060901
COMMIT/CCS-2 studies. Lancet (London, England) 20060819
Presence and development of atrial fibrillation in chronic heart failure. Experiences from the MERIT-HF Study. European journal of heart failure 20060801
Nonhypotensive dose of beta-adrenergic blocker ameliorates capillary deficits in the hearts of rats with moderate renal failure. Virchows Archiv : an international journal of pathology 20060801
Rationale, design, and organization of the PeriOperative ISchemic Evaluation (POISE) trial: a randomized controlled trial of metoprolol versus placebo in patients undergoing noncardiac surgery. American heart journal 20060801
Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8). Heart rhythm 20060801
Phaeochromocytomas presenting as acute crises after beta blockade therapy. Clinical endocrinology 20060801
Mechanisms underlying nebivolol-induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells. Clinical and experimental pharmacology & physiology 20060801
Elective surgery days after myocardial infarction: clinical and ethical considerations. Journal of clinical anesthesia 20060801
[Effects of atenolol and metoprolol on cardiomyocyte apoptosis and related gene expression after acute myocardial infarction in rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20060801
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial. Circulation 20060711
Intravenous administration of metoprolol is more effective than oral administration in the prevention of atrial fibrillation after cardiac surgery. Circulation 20060704
Lumen loss in the first year in saphenous vein grafts is predominantly a result of negative remodeling of the whole vessel rather than a result of changes in wall thickness. Circulation 20060704
Post-mortem redistribution of three beta-blockers in the rabbit. International journal of legal medicine 20060701
Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study. Naunyn-Schmiedeberg's archives of pharmacology 20060701
Beta1-adrenoceptor blockade mitigates excessive norepinephrine release into cardiac interstitium in mitral regurgitation in dog. American journal of physiology. Heart and circulatory physiology 20060701
Ibutilide to expedite ED therapy for recent-onset atrial fibrillation flutter. The American journal of emergency medicine 20060701
Carvedilol-induced antagonism of angiotensin II: a matter of alpha1-adrenoceptor blockade. Journal of hypertension 20060701
[Therapy of acute mayocardial infarction: COMMIT (Clopidogrel and Metoprolol Infarction Trial)]. Der Internist 20060701
beta1-Adrenergic receptor polymorphisms influence the response to metoprolol monotherapy in patients with essential hypertension. Clinical pharmacology and therapeutics 20060701
Idiopathic polymorphic ventricular tachycardia with normal QT interval in a structurally normal heart. Pacing and clinical electrophysiology : PACE 20060701
Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial. BMJ (Clinical research ed.) 20060624
[Arterial hypertension 3: Hypertensive crisis: hypertensive emergency and hypertensive urgency]. Praxis 20060621
Adherence and perception of medication in patients with chronic heart failure during a five-year randomised trial. Patient education and counseling 20060601
Ability of short-time Fourier transform method to detect transient changes in vagal effects on hearts: a pharmacological blocking study. American journal of physiology. Heart and circulatory physiology 20060601
Beta-blockers for cardiac CT: a primer for the radiologist. AJR. American journal of roentgenology 20060601
Management of type A aortic dissection and a large pheochromocytoma: a surgical dilemma. The Annals of thoracic surgery 20060601
Quality of life in the African American Study of Kidney Disease and Hypertension: effects of blood pressure management. American journal of kidney diseases : the official journal of the National Kidney Foundation 20060601
Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. The Journal of clinical investigation 20060601
Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. Journal of cardiac failure 20060601
Carvedilol versus Metoprolol for the prevention of atrial fibrillation after off-pump coronary bypass surgery: rationale and design of the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT). Cardiovascular drugs and therapy 20060601
[The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060601
More reasons doing less in syncope patients. Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20060601
Comparison of pyrroloquinoline quinone and/or metoprolol on myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury. Journal of cardiovascular pharmacology and therapeutics 20060601
[Estimation of effectiveness of the prevention of sudden cardiac death in patients with myocardial infarction]. Georgian medical news 20060601
The use of metoprolol CR/XL in the treatment of patients with diabetes and chronic heart failure. Vascular health and risk management 20060601
The effects of combined versus selective adrenergic blockade on left ventricular and systemic hemodynamics, myocardial substrate preference, and regional perfusion in conscious dogs with dilated cardiomyopathy. Journal of the American College of Cardiology 20060502
[Beneficial effects of metoprolol on perioperative cardiac function of elderly esophageal cancer patients]. Ai zheng = Aizheng = Chinese journal of cancer 20060501
Metoprolol succinate, a selective beta-adrenergic blocker, has no effect on insulin sensitivity. Journal of clinical hypertension (Greenwich, Conn.) 20060501
A comparison of the effects of carvedilol and metoprolol on well-being, morbidity, and mortality (the 'patient journey') in patients with heart failure: a report from the Carvedilol Or Metoprolol European Trial (COMET). Journal of the American College of Cardiology 20060418
Mapping the journey. Journal of the American College of Cardiology 20060418
Metoprolol reduces 'compensatory' coronary blood flow following occlusion of an adjacent branch without altering post-occlusion hyperaemia. Life sciences 20060411
Development of an oral sustained release drug delivery system utilizing pH-dependent swelling of carboxyvinyl polymer. Journal of controlled release : official journal of the Controlled Release Society 20060410
Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease. Archives of internal medicine 20060410
Screening approach for chiral separation of pharmaceuticals IV. Polar organic solvent chromatography. Journal of chromatography. A 20060407
Optimization of bilayer floating tablet containing metoprolol tartrate as a model drug for gastric retention. AAPS PharmSciTech 20060407
High-performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength detection. Biomedical chromatography : BMC 20060401
NO-dependent blood pressure regulation in RGS2-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology 20060401
Coronary MR imaging: breath-hold capability and patterns, coronary artery rest periods, and beta-blocker use. Radiology 20060401
A factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT). American journal of hypertension 20060401
The effect of extended-release metoprolol succinate on C-reactive protein levels in persons with hypertension. Journal of clinical hypertension (Greenwich, Conn.) 20060401
Sustained restoration of autonomic balance with long- but not short-acting metoprolol in patients with heart failure. Journal of cardiac failure 20060401
Pharmacokinetic and pharmacodynamic characteristics of beta-blockers: when differences may matter. Journal of cardiac failure 20060401
Endogenous uremic substances are not involved in the reduced hepatic extraction of metoprolol in bilateral ureter-ligated rats. Drug metabolism and pharmacokinetics 20060401
[Influences of perioperative metoprolol on hemodynamics and myocardial ischaemia in elderly patients undergoing noncardiac surgery]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20060401
Clopidogrel and metoprolol in myocardial infarction. Lancet (London, England) 20060311
Clopidogrel and metoprolol in myocardial infarction. Lancet (London, England) 20060311
Clopidogrel and metoprolol in myocardial infarction. Lancet (London, England) 20060311
Modulated release metoprolol succinate formulation based on ionic interactions: in vivo proof of concept. Journal of controlled release : official journal of the Controlled Release Society 20060310
Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope. Circulation 20060307
Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. British journal of pharmacology 20060301
Effects of metoprolol therapy on cardiac troponin-I levels after elective percutaneous coronary interventions. European heart journal 20060301
Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. Journal of hypertension 20060301
Carvedilol inhibits mitochondrial oxygen consumption and superoxide production during calcium overload in isolated heart mitochondria. Circulation journal : official journal of the Japanese Circulation Society 20060301
Acute myocardial infarction in a patient with severe unrecognized mitral stenosis. Medical science monitor : international medical journal of experimental and clinical research 20060301
Profound metoprolol-induced bradycardia precipitated by acetaminophen-propoxyphene. Clinical pharmacology and therapeutics 20060301
Effects of selective angiotensin II and beta1-receptor blockade on renal haemodynamics and sodium handling during orthostatic stress in healthy individuals. Journal of hypertension. Supplement : official journal of the International Society of Hypertension 20060301
Introduction of metoprolol increases plasma B-type cardiac natriuretic peptides in mild, stable heart failure. Circulation 20060221
Images in cardiovascular medicine. Bidirectional ventricular tachycardia caused by digitalis toxicity. Circulation 20060221
[Use of betablockers in elderly patients with congestive heart failure]. Medicina clinica 20060218
Enhanced sensitivity of dobutamine stress echocardiography by observing wall motion abnormalities during the recovery phase after acute beta-blocker administration. The American journal of cardiology 20060215
Broad complex tachycardia during treatment of atrial fibrillation with a 1c antiarrhythmic drug: ventricular or supraventricular proarrhythmia? International journal of cardiology 20060208
Favourable long term prognosis in stable angina pectoris: an extended follow up of the angina prognosis study in Stockholm (APSIS). Heart (British Cardiac Society) 20060201
Analysis of dissolution data using modified versions of Noyes-Whitney equation and the Weibull function. Pharmaceutical research 20060201
Prediction of drug-drug interactions for AUCoral of high clearance drug from in vitro data: utilization of a microtiter plate assay and a dispersion model. Current drug metabolism 20060201
The relevance of CYP2D6 genetic polymorphism on chronic metoprolol therapy in cardiovascular patients. Journal of clinical pharmacy and therapeutics 20060201
Medication costs as a primary cause of nonadherence in the elderly. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20060201
Use of simulated intestinal fluids with Caco-2 cells and rat ileum. Drug development and industrial pharmacy 20060201
After myocardial infarction carvedilol improves insulin resistance compared to metoprolol. Clinical research in cardiology : official journal of the German Cardiac Society 20060201
[Optimisation of the myocardial infarction pharmacotherapy--important insights from the COMMIT Trial]. Kardiologia polska 20060201
Quantitation of atenolol, metoprolol, and propranolol in postmortem human fluid and tissue specimens via LC/APCI-MS. Forensic science international 20060127
In vivo biotransformation of metoprolol in the horse and on-column esterification of the aminocarboxylic acid metabolite by alcohols during solid phase extraction using mixed mode columns. Journal of pharmaceutical and biomedical analysis 20060123
Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118
Spontaneous diastolic contractions and phosphorylation of the cardiac ryanodine receptor at serine-2808 in congestive heart failure in rat. Cardiovascular research 20060101
Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart. Cardiovascular research 20060101
A streamlined method to predict hepatic clearance using human liver microsomes in the presence of human plasma. Journal of pharmacological and toxicological methods 20060101
Influence of phenotype and pharmacokinetics on beta-blocker drug target pharmacogenetics. The pharmacogenomics journal 20060101
Use of natural gums and cellulose derivatives in production of sustained release metoprolol tablets. Drug delivery 20060101
Involvement of voltage-dependent Ca(2+) channel beta(3) subunit in the autonomic control of heart rate variability. Pharmacology 20060101
Pharmacogenetics, adverse drug reactions and public health. Community genetics 20060101
Comparison of carvedilol and metoprolol in patients with acute myocardial infarction undergoing primary coronary intervention--the PASSAT Study. Clinical research in cardiology : official journal of the German Cardiac Society 20060101
The anti-ischemic effect of metoprolol in patients with chronic angina pectoris is gender-specific. Cardiology 20060101
Permanent effects of postnatal administration of beta-adrenergic ligands on the volume of sexually dimorphic nucleus of the preoptic area (SDN-POA) in rats. Neuro endocrinology letters 20060101
The use of low-dose insulin in cardiogenic shock due to combined overdose of verapamil, enalapril and metoprolol. Cardiology 20060101
Application of continuous positive airway pressure in hypoxemic acute respiratory failure associated with diastolic dysfunction in pregnancy. Congestive heart failure (Greenwich, Conn.) 20060101
Preparation and characterization of metoprolol controlled-release solid dispersions. Drug delivery 20060101
Gender dependency of circadian blood pressure and heart rate profiles in spontaneously hypertensive rats: effects of beta-blockers. Chronobiology international 20060101
[Ischemic disease of the kidneys in a patient with morbid obesity: characteristics of the course and diagnostic policy]. Terapevticheskii arkhiv 20060101
Beta-blocker therapy for heart failure: should the therapeutic target be dose or heart rate reduction? Congestive heart failure (Greenwich, Conn.) 20060101
Metabolic effects of beta-adrenoceptor antagonists with special emphasis on carvedilol. American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101
[Headache induced by oral intake of metoprolol in a patient with chronic and limited cardiac tamponade]. Neurologia i neurochirurgia polska 20060101
Randomized, double-blind comparison of acute beta1-blockade with 50 mg metoprolol tartrate vs 25 mg carvedilol in normal subjects. Congestive heart failure (Greenwich, Conn.) 20060101
[Cardioselective beta-adrenoblockers in patients with stable angina pectoris. Comparison of efficacy and safety]. Terapevticheskii arkhiv 20060101
[Characteristics of action of various drugs blocking atrioventricular conduction (beta-blockers, verapamil, diltiazem) in constant fibrillation tachyarrhythmia. Is monotherapy optimal?]. Terapevticheskii arkhiv 20060101
Effectiveness and tolerability of acupuncture compared with metoprolol in migraine prophylaxis. Headache 20060101
Visual hallucinations and metoprolol. Psychosomatics 20060101
The suitability of an in situ perfusion model for permeability determinations: utility for BCS class I biowaiver requests. Molecular pharmaceutics 20060101
Effect of rat pretreatment with aqueous solutions of stevioside and bile acids on the action of certain cardioactive drugs. European journal of drug metabolism and pharmacokinetics 20060101
Troponin I release at rest and after exercise in patients with hypertrophic cardiomyopathy and the effect of betablockade. Archivos de cardiologia de Mexico 20060101
[Effect of low doses of metoprolol, bisoprolol and carvedilol on mortality in patients with left ventricular dysfunction after acute myocardial infarction]. Wiadomosci lekarskie (Warsaw, Poland : 1960) 20060101
Simvastatin intensifies heart rate depression after metoprolol and atropine administration in normocholesterolemic rats. Acta poloniae pharmaceutica 20060101
Determination of metoprolol and hydrochlorothiazide by derivative spectrophotometric method in pharmaceutical preparations. Acta poloniae pharmaceutica 20060101
Drug permeability in 16HBE14o- airway cell layers correlates with absorption from the isolated perfused rat lung. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051201
Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol. Journal of pharmaceutical sciences 20051201
Differential effects of beta-blockers on albuminuria in patients with type 2 diabetes. Hypertension (Dallas, Tex. : 1979) 20051201
Influence of chronic renal failure on stereoselective metoprolol metabolism in hypertensive patients. Journal of clinical pharmacology 20051201
Economic implications of extended-release metoprolol succinate for heart failure in the MERIT-HF trial: a US perspective of the MERIT-HF trial. Journal of cardiac failure 20051201
The effect of beta-blocker use on cyclosporine level in cardiac transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20051201
The role of the new beta-blockers in treating cardiovascular disease. American journal of hypertension 20051201
[Antihypertensive therapy with left cardiac insufficiency]. Medizinische Monatsschrift fur Pharmazeuten 20051201
Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy. Heart failure reviews 20051201
Something old, something new: beta blockers and clopidogrel in acute myocardial infarction. Lancet (London, England) 20051105
Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet (London, England) 20051105
Development of three layered buccal compact containing metoprolol tartrate by statistical optimization technique. International journal of pharmaceutics 20051104
Influence of heart rate, blood pressure, and beta-blocker dose on outcome and the differences in outcome between carvedilol and metoprolol tartrate in patients with chronic heart failure: results from the COMET trial. European heart journal 20051101
Influence of CYP2D6 genotype on metoprolol plasma concentration and beta-adrenergic inhibition during long-term treatment: a comparison with bisoprolol. Journal of cardiovascular pharmacology 20051101
Chronotropic incompetence as a predictor of death among patients with normal electrograms taking beta blockers (metoprolol or atenolol). The American journal of cardiology 20051101
Acute myocardial infarction complicated by pulmonary embolism after thrombolytic therapy: problems in clinical management. Chest 20051101
Exacerbation of migraine attacks during treatment with the selective serotonin reuptake inhibitor sertraline. A case report. Pharmacopsychiatry 20051101
Beta blockers for elective surgery in elderly patients: population based, retrospective cohort study. BMJ (Clinical research ed.) 20051022
Systolic compression of anomalous large septal branch: an unusual cause of myocardial ischemia. The international journal of cardiovascular imaging 20051001
The impact of diabetes or elevated fasting blood glucose on cardiovascular prognosis in patients with stable angina pectoris. Diabetic medicine : a journal of the British Diabetic Association 20051001
Impact of CYP2D6 genotype on adverse effects during treatment with metoprolol: a prospective clinical study. Clinical pharmacology and therapeutics 20051001
The effects of beta1-adrenergic blockade on cardiovascular oxygen flow in normoxic and hypoxic humans at exercise. European journal of applied physiology 20051001
Felodipine-metoprolol combination tablet: maintained health-related quality of life in the presence of substantial blood pressure reduction. American journal of hypertension 20051001
Regarding 'Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial'. Journal of vascular surgery 20051001
[Value of metoprolol injection at dobutamine-atropine stress echocardiography for detection of coronary artery disease]. Zhonghua xin xue guan bing za zhi 20051001
Carvedilol exerts more potent antiadrenergic effect than metoprolol in heart failure. Cardiovascular drugs and therapy 20051001
Protection against oxidative stress in diabetic rats: role of angiotensin AT(1) receptor and beta 1-adrenoceptor antagonism. European journal of pharmacology 20050927
[Delirium attributed to the use of metoprolol]. Nederlands tijdschrift voor geneeskunde 20050924
Stereoselective analysis of metoprolol and its metabolites in rat plasma with application to oxidative metabolism. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050905
Effects of beta-adrenoceptor antagonists in the neural nitric oxide release induced by electrical field stimulation and sodium channel activators in the rabbit corpus cavernosum. European journal of pharmacology 20050905
Effects of antiarrhythmic drug therapy on atrioventricular nodal function during atrial fibrillation in humans. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20050901
Effects of beta-blockers on implantable cardioverter defibrillator therapy and survival in the patients with ischemic cardiomyopathy (from the Multicenter Automatic Defibrillator Implantation Trial-II). The American journal of cardiology 20050901
[Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure]. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20050901
Effect of beta-blockers on cardiac function and calcium handling protein in postinfarction heart failure rats. Chest 20050901
Capillary electrochromatography with a neutral monolithic column for classification of analytes and determination of basic drugs in human serum. Electrophoresis 20050901
Gas chromatographic-mass spectrometric differentiation of atenolol, metoprolol, propranolol, and an interfering metabolite product of metoprolol. Journal of analytical toxicology 20050901
Carvedilol improves myocardial contractility compared with metoprolol in patients with chronic hibernating myocardium after revascularization. Journal of cardiovascular pharmacology and therapeutics 20050901
Early initiation of beta blockade in heart failure: issues and evidence. Journal of clinical hypertension (Greenwich, Conn.) 20050901
Recurrent symptomatic bradycardia due to secret ingestion of beta-blockers--a rare manifestation of cardiac Münchhausen syndrome. Wiener klinische Wochenschrift 20050901
Case records of the Massachusetts General Hospital. Case 26-2005. A 48-year-old man with sudden loss of consciousness while jogging. The New England journal of medicine 20050825
[Atenolol or metoprolol as beta-blocker in the treatment of hypertension]. Nederlands tijdschrift voor geneeskunde 20050806
Metoprolol prevents sodium retention induced by lower body negative pressure in healthy men. Kidney international 20050801
Beta blocker effects on plasma homocysteine levels in patients with hypertension. Atherosclerosis 20050801
Do metoprolol and carvedilol have equivalent effects on diurnal heart rate in patients with chronic heart failure? European journal of heart failure 20050801
Validated kinetic spectrophotometric method for the determination of metoprolol tartrate in pharmaceutical formulations. Chemical & pharmaceutical bulletin 20050801
Practical recommendations for the use of ACE inhibitors, beta-blockers, aldosterone antagonists and angiotensin receptor blockers in heart failure: putting guidelines into practice. European journal of heart failure 20050801
Vagal heart rate responses to chronic beta-blockade in human heart failure relate to cardiac norepinephrine spillover. European journal of heart failure 20050801
Hypothalamic antihypertensive effect of metoprolol in chronic aortic coarctated rats. Clinical and experimental pharmacology & physiology 20050801
Interaction between simvastatin and metoprolol with respect to cardiac beta-adrenoceptor density, catecholamine levels and perioperative catecholamine requirements in cardiac surgery patients. Naunyn-Schmiedeberg's archives of pharmacology 20050801
Autonomic nervous system influence on arterial baroreflex control of heart rate during exercise in humans. The Journal of physiology 20050715
Use of vancomycin chiral stationary phase for the enantiomeric resolution of basic and acidic compounds by nano-liquid chromatography. Journal of chromatography. A 20050715
Prognostic relevance of atrial fibrillation in patients with chronic heart failure on long-term treatment with beta-blockers: results from COMET. European heart journal 20050701
Blood pressure control, drug therapy, and kidney disease. Hypertension (Dallas, Tex. : 1979) 20050701
Celecoxib is often combined with cytochrome P450 2D6 substrates in general clinical practice. Clinical pharmacology and therapeutics 20050701
Slow supraventricular tachycardia in a patient on beta-blocker therapy. The American journal of emergency medicine 20050701
Central beta-adrenoceptors mediate phasic and sustained components of hemodynamic responses to acute behavioral stress. Brain research 20050628
Effects of long-term beta-blocker therapy on P-wave duration and dispersion in patients with rheumatic mitral stenosis. International journal of cardiology 20050622
[Does the use of metoprolol-succinate in patients with chronic heart failure lead to a higher efficacy in treatment without causing additional costs?]. MMW Fortschritte der Medizin 20050616
Effect of selective cyclooxygenase-2 inhibitors on heart rate in healthy young men. The American journal of cardiology 20050615
Metoprolol responding uveitis. Eye (London, England) 20050601
Modulation of metoprolol pharmacokinetics and hemodynamics by diphenhydramine coadministration during exercise testing in healthy premenopausal women. The Journal of pharmacology and experimental therapeutics 20050601
Quantitative assessment of regional peak myocardial acceleration during isovolumic contraction and relaxation times by tissue Doppler imaging. Heart (British Cardiac Society) 20050601
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry. Journal of the American Society for Mass Spectrometry 20050601
Comparison of the effectiveness of intravenous diltiazem and metoprolol in the management of rapid ventricular rate in atrial fibrillation. Emergency medicine journal : EMJ 20050601
Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response. European journal of heart failure 20050601
Selective versus nonselective beta-adrenergic receptor blockade in chronic heart failure: differential effects on myocardial energy substrate utilization. European journal of heart failure 20050601
Exchange of beta-blockers in heart failure patients. Experiences from the poststudy phase of COMET (the Carvedilol or Metoprolol European Trial). European journal of heart failure 20050601
Effects of beta-blocker therapy on ventilatory responses to exercise in patients with heart failure. Journal of cardiac failure 20050601
Drug and drug-device therapy in heart failure patients in the post-COMET and SCD-HeFT era. Journal of cardiovascular pharmacology and therapeutics 20050601
A review of carvedilol arrhythmia data in clinical trials. Journal of cardiovascular pharmacology and therapeutics 20050601
Usefulness of hepatocytes for evaluating the genetic polymorphism of CYP2D6 substrates. Xenobiotica; the fate of foreign compounds in biological systems 20050601
Prediction of oral clearance from in vitro metabolic data using recombinant CYPs: comparison among well-stirred, parallel-tube, distributed and dispersion models. Xenobiotica; the fate of foreign compounds in biological systems 20050601
[Numerous indications in cardiology. Beta receptor blockers can never be overlooked]. MMW Fortschritte der Medizin 20050505
Autonomic nervous system and blood pressure regulation in RGS2-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology 20050501
Long-term effects of carvedilol or metoprolol on left ventricular function in ischemic and nonischemic cardiomyopathy. The American journal of cardiology 20050501
Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050501
The VEGF +405 CC promoter polymorphism is associated with an impaired prognosis in patients with chronic heart failure: a MERIT-HF substudy. Journal of cardiac failure 20050501
Symptoms in patients with heart failure are prognostic predictors: insights from COMET. Journal of cardiac failure 20050501
Why do patients fail to receive beta-blockers for chronic heart failure over time? A 'real-world' single-center, 2-year follow-up experience of beta-blocker therapy in patients with chronic heart failure. American heart journal 20050501
Mechanism of action of metoprolol in reducing propofol-induced pain. European journal of anaesthesiology 20050501
[Effects of early treatment with metoprolol on myocardial inflammatory cytokine expression and heart function in rats with acute myocardial infarction]. Zhonghua xin xue guan bing za zhi 20050501
The effects of prior beta-blocker therapy on serum C-reactive protein levels after percutaneous coronary intervention. Clinical cardiology 20050501
[Nitric oxide and cardiologic drugs]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050501
The relationship between magnitude of proteinuria reduction and risk of end-stage renal disease: results of the African American study of kidney disease and hypertension. Archives of internal medicine 20050425
HPLC quantification of metoprolol with solid-phase extraction for the drug monitoring of pediatric patients. Biomedical chromatography : BMC 20050401
Initial risk assessment for three beta-blockers found in the aquatic environment. Chemosphere 20050401
Effects of different degrees of sympathetic antagonism on cytokine network in patients with ischemic dilated cardiomyopathy. Journal of cardiac failure 20050401
[Congestive heart failure in Spain: cost-effectiveness and cost-benefit analyses of treatment with beta-blockers]. Revista clinica espanola 20050401
Perioperative beta-blockade (POBBLE) for patients undergoing infrarenal vascular surgery: results of a randomized double-blind controlled trial. Journal of vascular surgery 20050401
Safety and accuracy of multidetector row computed tomography for early assessment of residual stenosis of the infarct-related artery and the number of diseased vessels after acute myocardial infarction. American heart journal 20050401
Are there clinically important differences between beta-blockers in heart failure? Heart failure clinics 20050401
Sympathetic cardiac influence and arterial blood pressure instability. Autonomic neuroscience : basic & clinical 20050331
Suppression by propranolol and amiodarone of an electrical storm refractory to metoprolol and amiodarone. International journal of cardiology 20050318
Death and hospitalization in heart failure patients receiving carvedilol vs. metoprolol tartrate. International journal of cardiology 20050310
Carvedilol, metoprolol, and insulin resistance. JAMA 20050309
Emerging trends in the management of heart failure: Beta blocker therapy. The Nursing clinics of North America 20050301
beta-Adrenergic receptor polymorphisms and responses during titration of metoprolol controlled release/extended release in heart failure. Clinical pharmacology and therapeutics 20050301
Association between adherence measurements of metoprolol and health care utilization in older patients with heart failure. Clinical pharmacology and therapeutics 20050301
Management of erosive lichen planus with topical tacrolimus and recurrence secondary to metoprolol. Journal of the European Academy of Dermatology and Venereology : JEADV 20050301
The effects of heart rate on myocardial velocity and atrio-ventricular displacement during exercise with and without beta-blockade: a tissue Doppler echocardiographic study. European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 20050301
Detrimental effects of beta-blockers in COPD: a concern for nonselective beta-blockers. Chest 20050301
Regression of carotid atherosclerosis by control of morning blood pressure peak in newly diagnosed hypertensive patients. American journal of hypertension 20050301
[Correlation between absorption rates of beta-adrenoreceptor antagonists in rat small intestine and their molecular structures]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050301
On-line cation-exchange preconcentration and capillary electrophoresis coupled by tee joint interface. Journal of chromatography. A 20050225
[Beta blockers for therapy of chronic heart failure]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050210
Pharmacokinetics and metabolism of metoprolol and propranolol in the female DA and female Wistar rat: the female DA rat is not always an animal model for poor metabolizers of CYP2D6. Journal of pharmaceutical sciences 20050201
Effect of beta-adrenoceptor blockers on human ether-a-go-go-related gene (HERG) potassium channels. Basic & clinical pharmacology & toxicology 20050201
I'm about to have elective surgery. My doctor recommended that I start taking a drug called metoprolol a few days before surgery to protect my heart. How does this work? Mayo Clinic health letter (English ed.) 20050201
Effects of metoprolol and carvedilol on cause-specific mortality and morbidity in patients with chronic heart failure--COMET. American heart journal 20050201
Dual effects of the lichen glucan PB-2, extracted from Flavoparmelia baltimorensis, on the induction of long-term potentiation in the dentate gyrus of the anesthetized rat: possible mediation via adrenaline beta- and interleukin-1 receptors. Brain research 20050125
What resting heart rate should one aim for when treating patients with heart failure with a beta-blocker? Experiences from the Metoprolol Controlled Release/Extended Release Randomized Intervention Trial in Chronic Heart Failure (MERIT-HF). Journal of the American College of Cardiology 20050118
Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. American journal of physiology. Heart and circulatory physiology 20050101
Critical differences among beta-adrenoreceptor antagonists in myocardial failure: debating the MERIT of COMET. Journal of clinical pharmacology 20050101
Dynamic changes in the QT-R-R relationship during head-up tilt test in patients with vasovagal syncope. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20050101
Current concepts of pharmacotherapy in hypertension. Carvedilol: new considerations for its use in the diabetic patient with hypertension. Journal of clinical hypertension (Greenwich, Conn.) 20050101
Efficacy, safety and tolerability of metoprolol CR/XL in patients with diabetes and chronic heart failure: experiences from MERIT-HF. American heart journal 20050101
Autonomic antecedents to variant angina exacerbation after beta-blockade withdrawal. Journal of electrocardiology 20050101
Carvedilol versus metoprolol in patients undergoing direct percutaneous coronary interventions for myocardial infarction: effects on QT dynamicity. Pacing and clinical electrophysiology : PACE 20050101
Carvedilol versus metoprolol in the acute phase of myocardial infarction: Pacing and clinical electrophysiology : PACE 20050101
The COMET trial. Congestive heart failure (Greenwich, Conn.) 20050101
The rationale and design of the Glycemic Effects in Diabetes Mellitus Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trial. Journal of diabetes and its complications 20050101
[Study of large-volume electrokinetic injection of capillary zone electrophoresis by using transient isotachophoresis]. Se pu = Chinese journal of chromatography 20050101
[Effects of ACE inhibitor fosinopril on a 24-h profile of arterial pressure in hypertensive patients with obesity and hypercholesterolemia]. Terapevticheskii arkhiv 20050101
[The place of metoprolol in the treatment of ischemic heart disease]. Kardiologiia 20050101
[Antiischemic and metabolic effects of nebivolol and metaprolol CR/XL (betalok ZOK) in patients with postinfarction heart dysfunction]. Klinicheskaia meditsina 20050101
Effect of beta-blocker therapy on myocardial perfusion defects in thallium-201 scintigraphy in patients with dilated cardiomyopathy. Cardiology 20050101
Thyrotoxicosis after gastric bypass surgery prompting operative re-exploration. Obesity surgery 20050101
[Clinical and prognostic value of therapy with contemporary beta-adrenoblockers in patients after myocardial infarction]. Kardiologiia 20050101
beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene. The pharmacogenomics journal 20050101
Beta1- or beta2-blockers to improve hemodynamics following endotracheal adrenaline administration. Drug metabolism and drug interactions 20050101
Anomalous origin of the left main coronary artery from the right sinus of Valsalva with an intramural course identified by transesophageal echocardiography in a 14 year old with acute myocardial infarction. Cardiology in review 20050101
Applicability of microdialysis as a technique for pharmacokinetic-pharmacodynamic (PK-PD) modeling of antihypertensive beta-blockers. Journal of pharmacological and toxicological methods 20050101
Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clinical pharmacokinetics 20050101
[Muscular mechanisms of lowering of physical working capacity in chronic heart failure and action of beta-adrenoblockers]. Kardiologiia 20050101
Protective effect of medication bezoar after a massive beta-blocker, digoxin, and amitriptyline poisoning. Clinical toxicology (Philadelphia, Pa.) 20050101
Bullous pemphigoid following therapy with an oral beta-blocker. Journal of drugs in dermatology : JDD 20050101
[Antihypertensive activity and effect on parameters of heart rate variability of beta-blockers carvedilol and metoprolol]. Kardiologiia 20050101
[Metoprolol and atenolol in mild-to-moderate chronic heart failure: comparative study]. Srpski arhiv za celokupno lekarstvo 20050101
[Beta-adrenolytics in heart failure--are they all really equal?]. Przeglad lekarski 20050101
[Suicide by intravenous injection of rocuronium-bromide--case report]. Srpski arhiv za celokupno lekarstvo 20050101
Blood pressure responses to whole-body cold exposure: effect of metoprolol. Journal of human hypertension 20041201
Impact of prophylactic postoperative beta-blockade on post-cardiothoracic surgery length of stay and atrial fibrillation. The Annals of pharmacotherapy 20041201
Assessment of in vivo CYP2D6 activity: differential sensitivity of commonly used probes to urine pH. Journal of clinical pharmacology 20041201
Cardiovascular and survival effects of sympatho-inhibitors in adriamycin-induced cardiomyopathy in rats. Fundamental & clinical pharmacology 20041201
Pharmacokinetics and CYP2D6 genotypes do not predict metoprolol adverse events or efficacy in hypertension. Clinical pharmacology and therapeutics 20041201
Consistency of the beneficial effect of metoprolol succinate extended release across a wide range dose of angiotensin-converting enzyme inhibitors and digitalis. Journal of cardiac failure 20041201
Beta-blocker improves survival, left ventricular function, and myocardial remodeling in hypertensive rats with diastolic heart failure. American journal of hypertension 20041201
[Effect of the polymorphism of the angiotensin-converting enzyme gene on the drug treatment in patients with chronic heart failure]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20041201
Effect of amiodarone on the plasma levels of metoprolol. The American journal of cardiology 20041115
[Recurrent hemispheric symptoms without proof of ischemia]. Deutsche medizinische Wochenschrift (1946) 20041112
Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial. JAMA 20041110
Pharmacokinetic evaluation of guar gum-based three-layer matrix tablets for oral controlled delivery of highly soluble metoprolol tartrate as a model drug. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20041101
Hypoglycemia associated with preoperative metoprolol administration. Anesthesia and analgesia 20041101
Metoprolol reduces the coronary collateral flow index: alternative explanations. European heart journal 20041101
Estimating mortality reduction by comparing survival curves. The Journal of family practice 20041101
[Rationale and methods of the UNAMET study (dose- and CYP2D6-genotype-dependent adverse drug reactions of metoprolol)--a contribution to quality improvement in pharmacotherapy]. Zeitschrift fur arztliche Fortbildung und Qualitatssicherung 20041101
Beneficial effect of cibenzoline on left ventricular pressure gradient with sigmoid septum. Circulation journal : official journal of the Japanese Circulation Society 20041001
Nonlinear mixed effects model analysis of the pharmacokinetics of metoprolol in routinely treated Japanese patients. Biological & pharmaceutical bulletin 20041001
Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics 20041001
Beta-adrenergic blockade and myocardial perfusion in coronary artery disease: differential effects in stenotic versus remote myocardial segments. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20041001
Salvage application of secondary blood cardioplegia in intractable ventricular fibrillation. Journal of cardiothoracic and vascular anesthesia 20041001
Determination of metoprolol, and its four metabolites in dog plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040925
Effectiveness of beta-blockade in experimental chronic aortic regurgitation. Circulation 20040914
[Treatment and prophylaxis of an acute migraine attack]. MMW Fortschritte der Medizin 20040902
Cerebral carbohydrate cost of physical exertion in humans. American journal of physiology. Regulatory, integrative and comparative physiology 20040901
A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. British journal of clinical pharmacology 20040901
Intestinal absorption and hepatic extraction of propranolol and metoprolol in rats with bilateral ureteral ligation. Biological & pharmaceutical bulletin 20040901
Efficacy of trimetazidine in patients with recurrent angina: a subgroup analysis of the TRIMPOL II study. Current medical research and opinion 20040901
Effects of cyclooxygenase inhibition on endothelial function in hypertensive patients treated with angiotensin-converting enzyme inhibitors. Clinical cardiology 20040901
Sudden death after IV metoprolol administration in a patient with cardiomyopathy. The American journal of emergency medicine 20040901
Hyperthyroidism as a cause of persistent vomiting. The Netherlands journal of medicine 20040901
Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation 20040831
[A randomized comparison of carvedilol and metoprolol in patients with chronic heart failure. The Carvedilol Or Metoprolol European Trial (COMET) ]. Ugeskrift for laeger 20040802
Metoprolol prophylaxis against postoperative atrial fibrillation increases length of hospital stay in patients not on pre-operative beta blockers: the beta blocker length of stay (BLOS) trial. Heart (British Cardiac Society) 20040801
Efficacy, safety and tolerability of beta-adrenergic blockade with metoprolol CR/XL in elderly patients with heart failure. European heart journal 20040801
Caution with beta1-adrenergic receptor genotyping. Clinical pharmacology and therapeutics 20040801
Brain natriuretic peptide response is heterogeneous during beta-blocker therapy for congestive heart failure. Journal of cardiac failure 20040801
Use of beta-blockers in older adults with chronic heart failure. The American journal of the medical sciences 20040801
Enantioseparation using sulfated cyclosophoraoses as a novel chiral additive in capillary electrophoresis. Electrophoresis 20040801
Accuracy of splitting unscored valdecoxib tablets. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040715
Adverse effects of beta-blocker therapy for patients with heart failure: a quantitative overview of randomized trials. Archives of internal medicine 20040712
[Therapy of chronic heart failure--carvedilol vs. metoprolol. COMET Study]. Der Internist 20040701
NMR spectroscopic characterization of metoprolol/cyclodextrin complexes in aqueous solution: cavity size dependency. Journal of pharmaceutical sciences 20040701
Hemodynamic and tissue oxygenation responses to exercise and beta-adrenergic blockade in patients with hyperthyroidism. Clinical cardiology 20040701
Pharmacokinetic-pharmacodynamic properties of metoprolol in chronic aortic coarctated rats. Naunyn-Schmiedeberg's archives of pharmacology 20040701
Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol. Cardiovascular drugs and therapy 20040701
How should COMET influence heart failure practice? Current heart failure reports 20040701
Beta-blockers in heart failure: is more better? Current heart failure reports 20040701
Comprehensive adrenergic receptor blockade with carvedilol is superior to beta-1-selective blockade with metoprolol in patients with heart failure: COMET. Current heart failure reports 20040701
Carvedilol but not metoprolol reduces beta-adrenergic responsiveness after complete elimination from plasma in vivo. Circulation 20040629
Carvedilol and metoprolol European trial: do the results merit challenge? American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040615
The effect of beta-blocker premedication on the surgical field during endoscopic sinus surgery. The Laryngoscope 20040601
Effects of metoprolol on QT interval and QT dispersion in Type 1 diabetic patients with abnormal albuminuria. Diabetologia 20040601
Effects of moxonidine vs. metoprolol on blood pressure and metabolic control in hypertensive subjects with type 2 diabetes. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040601
Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat. Toxicon : official journal of the International Society on Toxinology 20040601
Pharmacodynamics of beta-blockers in heart failure: lessons from the carvedilol or metoprolol European trial. Journal of cardiovascular pharmacology and therapeutics 20040601
[Inhibition of adenosine deaminase activity by drugs influencing the cardiovascular system]. Polskie Archiwum Medycyny Wewnetrznej 20040601
NFATc3-induced reductions in voltage-gated K+ currents after myocardial infarction. Circulation research 20040528
Commentary on the Carvedilol or Metoprolol European Trial (COMET). The American journal of cardiology 20040506
Ventricular remodeling in heart failure and the effect of beta-blockade. The American journal of cardiology 20040506
Advantages of a third-generation beta-blocker in patients with diabetes mellitus. The American journal of cardiology 20040506
Hemodynamic characterization of left ventricular function in experimental coxsackieviral myocarditis: effects of carvedilol and metoprolol. European journal of pharmacology 20040503
Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension (Dallas, Tex. : 1979) 20040501
The carvedilol or metoprolol European trial. Current cardiology reports 20040501
The update on the rationale, use and selection of beta-blockers in heart failure. Current opinion in cardiology 20040501
Metoprolol and coronary artery bypass grafting surgery: does intraoperative metoprolol attenuate acute beta-adrenergic receptor desensitization during cardiac surgery? Anesthesia and analgesia 20040501
Methods of assessing the functional status of patients with left ventricular systolic dysfunction in interventional studies: can brain natriuretic peptide measurement be used as surrogate for the traditional methods? Cardiovascular drugs and therapy 20040501
[Drug-induced headache and pain reduction medication with amitriptyline in an 11-year old pupil]. Der Nervenarzt 20040501
Effects of autoantibodies against beta(1)-adrenoceptor in hepatitis virus myocarditis on action potential and L-type Ca(2+) currents. World journal of gastroenterology 20040415
[Genetic polymorphisms in drug metabolizing enzymes--impact on treatment with beta-blockers]. Deutsche medizinische Wochenschrift (1946) 20040408
Effects of carvedilol on oxidative stress in human endothelial cells and healthy volunteers. European journal of clinical pharmacology 20040401
Metoprolol CR/XL improves systolic and diastolic left ventricular function in patients with chronic heart failure. Echocardiography (Mount Kisco, N.Y.) 20040401
A comparison between oral antiarrhythmic drugs in the prevention of atrial fibrillation after cardiac surgery: the pilot study of prevention of postoperative atrial fibrillation (SPPAF), a randomized, placebo-controlled trial. American heart journal 20040401
The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial: rationale and design of a multicenter, randomized, placebo-controlled, clinical trial of metoprolol for patients with diabetes mellitus who are undergoing major noncardiac surgery. American heart journal 20040401
Response to programmed ventricular stimulation and clinical outcome in cardiac arrest survivors receiving randomised assignment to implantable cardioverter defibrillator or antiarrhythmic drug therapy. European heart journal 20040401
Pincer nail deformity: inherited and caused by a beta-blocker. International journal of dermatology 20040401
Coronary collateral perfusion in patients with coronary artery disease: effect of metoprolol. European heart journal 20040401
Cardioprotective effects of carvedilol on acute autoimmune myocarditis. Molecular and cellular biochemistry 20040401
Heme oxygenase-1 gene expression in pericentral hepatocytes through beta1-adrenoceptor stimulation. Shock (Augusta, Ga.) 20040401
The effects of beta blockers on morbidity and mortality in heart failure. Heart failure reviews 20040401
Pharmacokinetics and pharmacodynamics of beta blockers in heart failure. Heart failure reviews 20040401
Beta blockers as anti-arrhythmic agents. Heart failure reviews 20040401
Effect of low-dose metoprolol in combination with sibutramine therapy in normotensive obese patients: a randomized controlled study. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20040301
Design and analysis of group sequential clinical trials with multiple primary endpoints. Biometrics 20040301
A description of the clinical characteristics at baseline of patients recruited into the Carvedilol or Metoprolol European Trial (COMET). Cardiovascular drugs and therapy 20040301
Do pharmacological differences among beta-blockers affect their clinical efficacy in heart failure? Cardiovascular drugs and therapy 20040301
Polymorphism in generic drug product development. Advanced drug delivery reviews 20040223
Plasma concentrations of epinephrine need to be monitored in study of incidence of hypotensive/bradycardic events. Anesthesia and analgesia 20040201
Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects. Fundamental & clinical pharmacology 20040201
Which beta-blocker for heart failure? American heart journal 20040201
Pheochromocytoma and pregnancy: a case report and review of anesthetic management. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20040201
Cost-effectiveness of differing perioperative beta-blockade strategies in vascular surgery patients. Journal of cardiothoracic and vascular anesthesia 20040201
Pharmacological rate control of atrial fibrillation. Cardiology clinics 20040201
Synthesis and cardiovascular activity of metoprolol analogues. Bioorganic & medicinal chemistry letters 20040105
Anterior hypothalamic beta-adrenergic activity in the maintenance of hypertension in aortic coarctated rats. Pharmacological research 20040101
Has COMET solved the controversy as to whether carvedilol is better than metoprolol in heart failure? Expert opinion on pharmacotherapy 20040101
Cardioprotective effects of carvedilol on acute autoimmune myocarditis: anti-inflammatory effects associated with antioxidant property. American journal of physiology. Heart and circulatory physiology 20040101
Patterns of beta-blocker utilization in patients with chronic heart failure: experience from a specialized outpatient heart failure clinic. American heart journal 20040101
Metoprolol responding uveitis. Eye (London, England) 20040101
Shock on T versus direct current voltage for induction of ventricular fibrillation: a randomized prospective comparison. Pacing and clinical electrophysiology : PACE 20040101
Effects of a beta-blocker on ventricular late potentials in patients with acute anterior myocardial infarction receiving successful thrombolytic therapy. Japanese heart journal 20040101
Effectiveness of metoprolol in preventing atrial fibrillation and flutter in the postoperative period of coronary artery bypass graft surgery. Arquivos brasileiros de cardiologia 20040101
Effects of therapy with amiodarone on clinical, functional, and cardiac sympathetic innervation in patients with idiopathic dilated cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20040101
Efficacy of amiodarone treatment on cardiac symptom, function, and sympathetic nerve activity in patients with dilated cardiomyopathy: comparison with beta-blocker therapy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20040101
[The state of microcirculation during use of long acting metoprolol]. Kardiologiia 20040101
Transdermal drug delivery systems of a beta blocker: design, in vitro, and in vivo characterization. Drug delivery 20040101
Nonselective versus selective beta-blockers in the management of chronic heart failure: clinical implications of the carvedilol or Metoprolol European Trial. Reviews in cardiovascular medicine 20040101
Optic neuropathy: puls/minus. Survey of ophthalmology 20040101
Relation between pharmacodynamic and anthropometric parameters during ergometry at rest and after repeated intake of metoprolol in healthy volunteers: results of a pilot study. Acta physiologica Hungarica 20040101
Experience with beta-blockers in long term management of peripartum cardiomyopathy. Journal of Ayub Medical College, Abbottabad : JAMC 20040101
[Correction of baroreflex sensitivity impairment and efficacy of prevention of sudden arrhythmic death in patients with postinfarction left ventricular dysfunction]. Kardiologiia 20040101
Determination of three beta-blockers in biofluids and solid tissues by liquid chromatography-electrospray-mass spectrometry. Journal of analytical toxicology 20040101
The effect of food on the relative bioavailability of rapidly dissolving immediate-release solid oral products containing highly soluble drugs. Molecular pharmaceutics 20040101
[Beta-blocking drugs indicated in patients with heart failure]. Nederlands tijdschrift voor geneeskunde 20031213
[Is 'COMET' pointing in the right direction?--Pro]. Deutsche medizinische Wochenschrift (1946) 20031212
[Is 'COMET' pointing in the right direction?--Con]. Deutsche medizinische Wochenschrift (1946) 20031212
Strain rate acceleration yields a better index for evaluating left ventricular contractile function as compared with tissue velocity acceleration during isovolumic contraction time: an in vivo study. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20031201
Aortic aneurysm and electroconvulsive therapy in elderly depressive patient. The journal of ECT 20031201
[The arrhythmogenic right ventricular cardiomyopathy (ARVC)]. Zeitschrift fur Kardiologie 20031201
Myocardial beta-1 adrenoceptor down-regulation in aging and heart failure: implications for beta-blocker use in older adults with heart failure. European journal of heart failure 20031201
Selective beta1-blockade attenuates post-infarct remodelling without improvement in myocardial energy metabolism and function in rats with heart failure. European journal of heart failure 20031201
In heart failure, all beta-blockers are not necessarily equal. Cleveland Clinic journal of medicine 20031201
Reduction (TELMAR) as assessed by magnetic resonance imaging in patients with mild-to-moderate hypertension--a prospective, randomised, double-blind comparison of telmisartan with metoprolol over a period of six months rationale and study design. Journal of the renin-angiotensin-aldosterone system : JRAAS 20031201
Case studies in heart failure. Critical care nursing clinics of North America 20031201
Radical mechanisms in the radiosterilization of metoprolol tartrate solutions. Pharmaceutical research 20031201
A comment on COMET: how to interpret a positive trial? Journal of cardiac failure 20031201
Do beta-blockers prolong survival in heart failure only by inhibiting the beta1-receptor? A perspective on the results of the COMET trial. Journal of cardiac failure 20031201
Selective versus nonselective beta-blockade for heart failure therapy: are there lessons to be learned from the COMET trial? Journal of cardiac failure 20031201
A clinical pharmacologist's response to Dr Milton Packer's perspective on the results of the COMET trial. Journal of cardiac failure 20031201
Beta-blockers for heart failure. Journal of cardiac failure 20031201
Partial reversal of cachexia by beta-adrenergic receptor blocker therapy in patients with chronic heart failure. Journal of cardiac failure 20031201
The effect of beta-blocker on hamster model BIO 53.58 with dilated cardiomyopathy determined using 123I-MIBG myocardial scintigraphy. Annals of nuclear medicine 20031201
[Beta blocker in heart failure. Dosage too low]. MMW Fortschritte der Medizin 20031120
Myocardial strain rate is a superior method for evaluation of left ventricular subendocardial function compared with tissue Doppler imaging. Journal of the American College of Cardiology 20031105
Beta-blockers for chronic heart failure: surviving longer but feeling better? International journal of cardiology 20031101
Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells. Japanese heart journal 20031101
Comparison of metoprolol with low, middle and high doses of carvedilol in prevention of postinfarction left ventricular remodeling in rats. Japanese heart journal 20031101
[A fairer comparison between carvedilol and metoprolol is still to be done]. Lakartidningen 20031030
Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors. Neuroreport 20031027
Acute beta-blockade reduces the extent and severity of myocardial perfusion defects with dipyridamole Tc-99m sestamibi SPECT imaging. Journal of the American College of Cardiology 20031015
Reduction in dipyridamole-induced single-photon emission computed tomography myocardial defect size by beta-blockers: time to re-examine the patient preparation protocol for pharmacologic stress testing. Journal of the American College of Cardiology 20031015
[Comparative study in heart failure. Which beta blocker saves more life time?]. MMW Fortschritte der Medizin 20031002
The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure. Heart (British Cardiac Society) 20031001
Comparative impact of enalapril, candesartan or metoprolol alone or in combination on ventricular remodelling in patients with congestive heart failure. European heart journal 20031001
Efficacy of carvedilol treatment on cardiac function and cardiac sympathetic nerve activity in patients with dilated cardiomyopathy: comparison with metoprolol therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20031001
Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clinical pharmacology and therapeutics 20031001
Effects of a beta blocker and spironolactone on plasma homocysteine levels. International journal of cardiology 20031001
The heart of Daphnia magna: effects of four cardioactive drugs. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20031001
Metoprolol CR/XL in postmyocardial infarction patients with chronic heart failure: experiences from MERIT-HF. American heart journal 20031001
Increased exercise ejection fraction and reversed remodeling after long-term treatment with metoprolol in congestive heart failure: a randomized, stratified, double-blind, placebo-controlled trial in mild to moderate heart failure due to ischemic or idiopathic dilated cardiomyopathy. European journal of heart failure 20031001
A COMET lost. Italian heart journal : official journal of the Italian Federation of Cardiology 20031001
COMET: a proposed mechanism of action to explain the results and concerns about dose. Lancet (London, England) 20030927
COMET: a proposed mechanism of action to explain the results and concerns about dose. Lancet (London, England) 20030927
COMET: a proposed mechanism of action to explain the results and concerns about dose. Lancet (London, England) 20030927
Comparison of effectiveness of carvedilol versus metoprolol or atenolol for atrial fibrillation appearing after coronary artery bypass grafting or cardiac valve operation. The American journal of cardiology 20030915
[The COMET study compares effect of two different beta-blockers in chronic heart failure. Carvedilol better than metoprolol]. Lakartidningen 20030911
Effect of CYP2D6*10 on pharmacokinetic variability of routinely administered metoprolol in middle-aged and elderly Japanese patients. European journal of clinical pharmacology 20030901
Effects of cold exposure on submaximal exercise performance and adrenergic activation in patients with congestive heart failure and the effects of beta-adrenergic blockade (carvedilol or metoprolol). The American journal of cardiology 20030901
A new method using pulmonary gas-exchange kinetics to evaluate efficacy of beta-blocking agents in patients with dilated cardiomyopathy. Chest 20030901
A study on the release mechanism of drugs from hydrophilic partially coated perforated matrices. Farmaco (Societa chimica italiana : 1989) 20030901
Metoprolol, a beta-1 selective blocker, can be used safely in coronary artery disease patients with chronic obstructive pulmonary disease. Heart and vessels 20030901
[Comet or snoop?]. Medizinische Monatsschrift fur Pharmazeuten 20030901
Iontophoretic in vivo transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation. Pharmaceutical research 20030901
Top heart failure drugs compared. Health news (Waltham, Mass.) 20030901
Effects of spironolactone and metoprolol on QT dispersion in heart failure. Japanese heart journal 20030901
Beta-blocker efficacy according to heart rate and rhythm in patients with heart failure. Commentary on the Cardiac Insufficiency Bisoprolol Study II analysis. Cardiac electrophysiology review 20030901
How should subgroup analyses affect clinical practice? Insights from the Metoprolol Succinate Controlled-Release/Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF). Cardiac electrophysiology review 20030901
Comparative effects of carvedilol and metoprolol on regional vascular responses to adrenergic stimuli in normal subjects and patients with chronic heart failure. Circulation 20030826
Lack of inverse agonistic activity of nebivolol, its D- and L-enantiomers and of in vivo metabolized nebivolol in human myocardium. European journal of pharmacology 20030822
Effect of beta blockade (carvedilol or metoprolol) on activation of the renin-angiotensin-aldosterone system and natriuretic peptides in chronic heart failure. The American journal of cardiology 20030815
Metoprolol CR/XL in black patients with heart failure (from the Metoprolol CR/XL randomized intervention trial in chronic heart failure). The American journal of cardiology 20030815
Statin therapy restores sympathovagal balance in experimental heart failure. Journal of applied physiology (Bethesda, Md. : 1985) 20030801
Effect of beta-blockers on insulin resistance in patients with dilated cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society 20030801
Celecoxib inhibits metabolism of cytochrome P450 2D6 substrate metoprolol in humans. Clinical pharmacology and therapeutics 20030801
Immediate- vs extended-release metoprolol in heart failure. The Journal of family practice 20030801
An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. European journal of heart failure 20030801
Clinical trials update from the European Society of Cardiology Heart Failure meeting: COMET, COMPANION, Tezosentan and SHAPE. European journal of heart failure 20030801
Effects of moxonidine and metoprolol in penile circulation in hypertensive men with erectile dysfunction: results of a pilot study. International journal of impotence research 20030801
Decreased heart rate recovery after exercise in patients with congestive heart failure: effect of beta-blocker therapy. Journal of cardiac failure 20030801
Partial agonist activity of bucindolol is dependent on the activation state of the human beta1-adrenergic receptor. Circulation 20030722
Beta1-adrenergic receptor blockade attenuates angiotensin II-mediated catecholamine release into the cardiac interstitium in mitral regurgitation. Circulation 20030715
Choosing metoprolol or carvedilol in heart failure (a pre-COMET commentary). The American journal of cardiology 20030715
[For the first time beta blockers are in direct comparison With carvedilol weak hearts beat longer]. MMW Fortschritte der Medizin 20030710
Beta blockers in heart failure. Lancet (London, England) 20030705
Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomised controlled trial. Lancet (London, England) 20030705
Comparison of frequency of recurrent syncope after beta-blocker therapy versus conservative management for patients with vasovagal syncope. The American journal of cardiology 20030701
Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clinical pharmacology and therapeutics 20030701
Interaction of quinidine, disopyramide and metoprolol with melanin in vitro in relation to drug-induced ocular toxicity. Die Pharmazie 20030701
Should beta-blockers form the cornerstone for the treatment of congestive heart failure? Expert review of cardiovascular therapy 20030701
Antiatherosclerotic effects of beta-blockers. The American journal of cardiology 20030619
QT dispersion after beta-blocker therapy (carvedilol or metoprolol) in children with heart failure. The American journal of cardiology 20030615
Different responses to dobutamine in the presence of carvedilol or metoprolol in patients with chronic heart failure. Heart (British Cardiac Society) 20030601
Stereoselective metabolism of metoprolol: enantioselectivity of alpha-hydroxymetoprolol in plasma and urine. Chirality 20030601
Interaction between noradrenaline or adrenaline and the beta 1-adrenergic receptor in the nervous system triggers early metamorphosis of larvae in the ascidian, Ciona savignyi. Developmental biology 20030601
Beta-blocker benefit according to severity of heart failure. European journal of heart failure 20030601
Pain on injection of propofol: comparison of metoprolol with lidocaine. European journal of anaesthesiology 20030601
Cocaine produces cardiac hypertrophy by protein kinase C dependent mechanisms. Journal of cardiovascular pharmacology and therapeutics 20030601
A case of electrical storm in a liver transplant patient. Transplantation proceedings 20030601
Direct enantiomeric resolution of (+/-)-atenolol, (+/-)-metoprolol, and (+/-)-propranolol by impregnated TLC using L-aspartic acid as chiral selector. Biomedical chromatography : BMC 20030601
Matrix type transdermal drug delivery systems of metoprolol tartrate: in vitro characterization. Acta pharmaceutica (Zagreb, Croatia) 20030601
Value of rapid beta-blocker injection at peak dobutamine-atropine stress echocardiography for detection of coronary artery disease. Journal of the American College of Cardiology 20030507
Extended-release metoprolol succinate in chronic heart failure. The Annals of pharmacotherapy 20030501
[Use of beta-blockers in heart failure]. Nihon rinsho. Japanese journal of clinical medicine 20030501
[The changes of plasma levels of brain natriuretic peptides in evaluation of treatment responses in chronic heart failure]. Zhonghua nei ke za zhi 20030501
Polymeric matrix membrane sensors for sensitive potentiometric determination of some beta-blockers in pharmaceutical preparations. Journal of pharmaceutical and biomedical analysis 20030424
An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin. Forensic science international 20030423
Beta1-adrenoceptor antibodies induce apoptosis in adult isolated cardiomyocytes. European journal of pharmacology 20030411
[Antihypertensive first-line and add-on treatment with a fixed controlled release combination of metoprololsuccinate/hydrochlorothiazide. Prospective doctor's office observational study in 14,964 patients]. MMW Fortschritte der Medizin 20030403
Angiotensin-converting enzyme inhibition but not beta-adrenergic blockade limits transforming growth factor-beta overexpression in acute normotensive anti-thy1 glomerulonephritis. Journal of hypertension 20030401
Long-term effects of beta blocker therapy on P-wave duration and dispersion in congestive heart failure patients: a new effect? Journal of electrocardiology 20030401
Tolerability of beta-blockers in heart failure: reassurance needed, reassurance provided. Italian heart journal : official journal of the Italian Federation of Cardiology 20030401
Role of metoprolol, B1-adrenoceptor antagonist, thromboxane A2 and nitric oxide in CsA-induced hypertension. Prostaglandins, leukotrienes, and essential fatty acids 20030301
In vivo and in vitro pharmacodynamic properties of metoprolol in aortic coarctated rats. Pharmacological research 20030301
Treatment of chronic heart failure with beta adrenergic blockade beyond controlled clinical trials: the BRING-UP experience. Heart (British Cardiac Society) 20030301
Isozyme-specific induction of low-dose aspirin on cytochrome P450 in healthy subjects. Clinical pharmacology and therapeutics 20030301
Effects of a beta-blocker and spironolactone on plasma homocysteine levels. International journal of cardiology 20030301
The mean dissolution time depends on the dose/solubility ratio. Pharmaceutical research 20030301
Pharmacokinetic considerations of formulation: extended-release metoprolol succinate in the treatment of heart failure. Journal of cardiovascular pharmacology 20030201
Effects of verapamil and metoprolol on recovery from atrial electrical remodeling after cardioversion of long-lasting atrial fibrillation. International journal of cardiology 20030201
Successful implementation of perioperative beta-blockade utilizing a multidisciplinary approach. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030201
Overexpression of eNOS in RVLM improves impaired baroreflex control of heart rate in SHRSP. Rostral ventrolateral medulla. Stroke-prone spontaneously hypertensive rats. Hypertension (Dallas, Tex. : 1979) 20030201
Double-blind, placebo-controlled, randomized trial of prophylactic metoprolol for reduction of hospital length of stay after heart surgery: the beta-Blocker Length Of Stay (BLOS) study. American heart journal 20030201
Marked improvement in left ventricular ejection fraction during long-term beta-blockade in patients with chronic heart failure: clinical correlates and prognostic significance. American heart journal 20030201
ACE inhibition is effective and renoprotective in hypertensive nephrosclerosis: the African American Study of Kidney Disease and Hypertension (AASK) trial. Kidney international. Supplement 20030201
[Competitive sports and dilated cardiomyopathy: the case of a 32-year-old soccer player with ventricular tachycardia]. Deutsche medizinische Wochenschrift (1946) 20030124
Vasopressor response to angiotensin II infusion in patients with chronic heart failure receiving beta-blockers. Circulation 20030121
[Moxonidine is advantageous for hypertensive type 2 diabetic patients. Therapy of hypertension also lowers HbA1c]. MMW Fortschritte der Medizin 20030116
Enantioselective determination of metoprolol acidic metabolite in plasma and urine using liquid chromatography chiral columns: applications to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030115
Clinical outcomes in patients on beta-blocker therapy admitted with worsening chronic heart failure. The American journal of cardiology 20030115
Carvedilol increases the production of interleukin-12 and interferon-gamma and improves the survival of mice infected with the encephalomyocarditis virus. Journal of the American College of Cardiology 20030115
Dosage conversions as a potential cause of adverse drug events. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030115
Prevention of Syncope Trial (POST): a randomized clinical trial of beta blockers in the prevention of vasovagal syncope; rationale and study design. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20030101
Determination of beta-adrenergic receptor blocking pharmaceuticals in United States wastewater effluent. Environmental pollution (Barking, Essex : 1987) 20030101
Image quality in a standardized algorithm for minimally invasive coronary angiography with multislice spiral computed tomography. Journal of computer assisted tomography 20030101
Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: development and evaluation. Drug delivery 20030101
[Clinical significance of adrenoreactivity in patients with some paroxysmal disorders (panic attacks and migraine)]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20030101
Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase. Molecular and cellular biochemistry 20030101
The African American Study of Kidney Disease and Hypertension (AASK) trial: what more have we learned? Journal of clinical hypertension (Greenwich, Conn.) 20030101
Usefulness of intravenous metoprolol during positive isoproterenol tilt-table test in the choice of treatment for neurocardiogenic syncope. Indian heart journal 20030101
Gunshot injury of the heart: an unusual cause of acute myocardial infarction. Texas Heart Institute journal 20030101
Use of beta-blockers in congestive heart failure. Annals of medicine 20030101
[Clinical and metabolic effects of cardioselective beta-adrenoblockers nebivolol and metoprolol in patients with hypertension and ischemic heart disease associated with type 2 diabetes]. Kardiologiia 20030101
[Effect of metoprolol CR/XL on remodeling of the heart and cardiac rhythm disturbances after myocardial infarction in patients with chronic heart failure]. Kardiologiia 20030101
Effect of antianginal medication on resting myocardial perfusion and pharmacologically induced hyperemia. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20030101
Antianginal medications and diagnostic accuracy of myocardial perfusion imaging. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20030101
[Interrelationship between electrophysiological markers of arrhythmogenicity and psychoemotional status of patients with myocardial infarction]. Kardiologiia 20030101
Dramatic new trial results settle controversy in chronic heart failure. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20030101
[Pharmacological modulation of NO synthesis in patients with arterial hypertension and endothelial dysfunction]. Klinicheskaia meditsina 20030101
Precipitation of PTSD with metoprolol for hypertension. Psychosomatics 20030101
[Efficacy and safety of different beta-blockers in patients with isolated systolic hypertension associated with diabetes mellitus and obstructive pulmonary diseases]. Terapevticheskii arkhiv 20030101
Refractory adenosine-sensitive congenital His bundle tachycardia: response to calcium-channel blockers. Indian heart journal 20030101
Beta-blocker treatment of chronic heart failure: comparison of carvedilol and metoprolol. Congestive heart failure (Greenwich, Conn.) 20030101
[The use of intra-aortic balloon counterpulsation in the treatment of severe hemodynamic instability from myocardial depressant drug overdose]. Przeglad lekarski 20030101
[Effect of beta-blockers metoprolol CR/XL and carvedilol on left ventricular contractility in patients with chronic low cardiac output]. Terapevticheskii arkhiv 20030101
[Metoprolol CR/XL: advanced formulation of a classical beta-blocker]. Kardiologiia 20030101
AVID and COMET. Preventive cardiology 20030101
[Metoprolol in the treatment of essential hypertension]. Kardiologiia 20030101
Clinical manifestations of hyperthyroidism after treatment with selective beta 1 adrenoceptor blocking agents. Proceedings of the Western Pharmacology Society 20030101
The effect of propranolol, atenolol and metoprolol on the serum levels of thyroxin (T4) and triiodothyronine (T3). Proceedings of the Western Pharmacology Society 20030101
Alteration of growth and metabolic activity of cells in the presence of propranolol and metoprolol. Acta poloniae pharmaceutica 20030101
[Assessment of the efficacy and tolerance of delayed-action nifedipine as the monotherapy or in combination with metoprolol in patients with arterial hypertension]. Terapevticheskii arkhiv 20030101
[Toxicologic analysis of some adrenergic-beta blockers in the diagnosis of intoxications]. Archiwum medycyny sadowej i kryminologii 20030101
The European Society of Cardiology working group on heart failure: Heart Failure Update 2003. Heart failure monitor 20030101
[Treatment of cardiovascular diseases with beta-blockers: the place of metoprolol and its various drug formulations]. Kardiologiia 20030101
[Antihypertensive first-line and add-on treatment with a fixed controlled release combination of metoprololsuccinate/hydrochlorothiazide. Prospective doctor's office observational study in 14,964 patients]. Fortschritte der Medizin. Originalien 20030101
Enantiomeric separations of amino alcohols by packed-column SFC on Hypercarb with L-(+)-tartaric acid as chiral selector. Journal of biochemical and biophysical methods 20021231
Motor vehicle accident with complete loss of consciousness due to vasovagal syncope. Forensic science international 20021204
Pharmacological blockade of the dive response: effects on heart rate and diving behaviour in the harbour seal (Phoca vitulina). The Journal of experimental biology 20021201
Development, validation and analytical error function of two chromatographic methods with fluorimetric detection for the determination of bisoprolol and metoprolol in human plasma. Biomedical chromatography : BMC 20021201
Diagnostic value of simultaneous non-invasive continuous, ambulatory finger blood pressure and electrocardiogram monitoring in a patient with hypertrophic obstructive cardiomyopathy. Blood pressure monitoring 20021201
Use of thallium-201 myocardial scintigraphy for the prediction of the response to beta-blocker therapy in patients with dilated cardiomyopathy. Circulation journal : official journal of the Japanese Circulation Society 20021201
Comparison of treatment effects of bevantolol and metoprolol on cardiac function and natriuretic peptides in patients with dilated cardiomyopathy. Heart and vessels 20021201
Ethnic, racial, and sex-specific factors are important in cardiovascular pharmacotherapeutics. Archives of internal medicine 20021125
Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trial. JAMA 20021120
Effects of long-term beta-blocker (metoprolol or carvedilol) therapy on QT variability in subjects with chronic heart failure secondary to ischemic cardiomyopathy. The American journal of cardiology 20021115
Paradoxical effect of sibutramine on autonomic cardiovascular regulation. Circulation 20021105
Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021101
Effectiveness of amiodarone therapy in patients with severe congestive heart failure and intolerance to metoprolol. The American journal of cardiology 20021101
Beta-blocker decreases the increase in QT dispersion and transmural dispersion of repolarization induced by bepridil. Circulation journal : official journal of the Japanese Circulation Society 20021101
Improvement of insulin sensitivity by a long-acting nifedipine preparation (nifedipine-CR) in patients with essential hypertension. American journal of hypertension 20021101
Efficacy of metoprolol and sotalol in the prevention of recurrences of sustained ventricular tachyarrhythmias in patients with an implantable cardioverter defibrillator. Pacing and clinical electrophysiology : PACE 20021101
Coordinate changes in Myosin heavy chain isoform gene expression are selectively associated with alterations in dilated cardiomyopathy phenotype. Molecular medicine (Cambridge, Mass.) 20021101
Beta-blockers in heart failure: how far have we progressed? Postgraduate medicine 20021101
Consistency of ss-blocker effect across various subgroups with heart failure: insights from the MERIT-HF trial. Postgraduate medicine 20021101
Use of beta-blockers for heart failure in patients with diabetes mellitus. Postgraduate medicine 20021101
[Inhibitory action of metoprolol and gamma--aminobutyric acid on heart rhythm disorder induced by administration of endothelin-1 into rostral ventrolateral medulla in cats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20021101
Combined endpoints: can we use them? Statistics in medicine 20021015
Beta-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol. Journal of the American College of Cardiology 20021002
Effects of metoprolol in chagasic patients with severe congestive heart failure. International journal of cardiology 20021001
Combined effects of metoprolol and spironolactone in dilated cardiomyopathic hamsters. Journal of cardiovascular pharmacology 20021001
[Prevention and treatment of congestive heart failure in diabetic patients]. Revista espanola de cardiologia 20021001
Increased frequency of cytochrome P450 2D6 poor metabolizers among patients with metoprolol-associated adverse effects. Clinical pharmacology and therapeutics 20021001
Influence of beta-adrenoceptor antagonists on hemorrhage-induced cellular immune suppression. Shock (Augusta, Ga.) 20021001
Neurohumoral prediction of left-ventricular morphologic response to beta-blockade with metoprolol in chronic left-ventricular systolic heart failure. European journal of heart failure 20021001
Effects of ACE inhibitor and beta-adrenergic blocker on plasma NPY and NPY receptors in aortic vascular smooth muscle cells from SHR and WKY rats. Neuropeptides 20021001
[Brazilian consensus for the thrombolysis in acute ischemic stroke]. Arquivos de neuro-psiquiatria 20020901
TCM treatment of hypertrophic cardiomyopaphy--a case report. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20020901
Effects of long-term monotherapy with metoprolol CR/XL on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure. Cardiovascular drugs and therapy 20020901
Beta-blockers and diabetes: the bad guys come good. Cardiovascular drugs and therapy 20020901
Influence of complex solubility on formulations based on lambda carrageenan and basic drugs. AAPS PharmSciTech 20020901
The myocardium-protective Gly-49 variant of the beta 1-adrenergic receptor exhibits constitutive activity and increased desensitization and down-regulation. The Journal of biological chemistry 20020823
Acute effects of vasoactive drug treatment on brachial artery reactivity. Journal of the American College of Cardiology 20020821
Dose of metoprolol CR/XL and clinical outcomes in patients with heart failure: analysis of the experience in metoprolol CR/XL randomized intervention trial in chronic heart failure (MERIT-HF). Journal of the American College of Cardiology 20020807
Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina. Investigative ophthalmology & visual science 20020801
Intermediate effects of treatment with metoprolol or carvedilol in children with left ventricular systolic dysfunction. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20020801
Current research on carvedilol in heart failure. Critical care nurse 20020801
Is beta-blockade useful in heart failure patients with atrial fibrillation? An analysis of data from two previously completed prospective trials. European journal of heart failure 20020801
Dobutamine gated blood pool scintigraphy predicts the improvement of cardiac sympathetic nerve activity, cardiac function, and symptoms after treatment in patients with dilated cardiomyopathy. Chest 20020801
Effect of the CYP2D6 genotype on metoprolol metabolism persists during long-term treatment. Pharmacogenetics 20020801
Beneficial effects of metoprolol on myocardial sympathetic function: Evidence from a randomized, placebo-controlled study in patients with congestive heart failure. American heart journal 20020801
A three-layer guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate. International journal of pharmaceutics 20020725
Effects on heart rate variability of metoprolol supplementary to ongoing ACE-inhibitor treatment in Type I diabetic patients with abnormal albuminuria. Diabetologia 20020701
[Treatment of heart failure: an update]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20020701
Effect of metoprolol on absolute myocardial blood flow in patients with heart failure secondary to ischemic or nonischemic cardiomyopathy. The American journal of cardiology 20020615
Cardiac 123 I-MIBG imaging and clinical variables in risk stratification in patients with heart failure treated with beta blockers. Nuclear medicine communications 20020601
Rationale and design of the carvedilol or metoprolol European trial in patients with chronic heart failure: COMET. European journal of heart failure 20020601
Myocardial oxidative metabolism in remote normal regions in the left ventricles with remodeling after myocardial infarction: effect of beta-adrenoceptor blockers. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20020601
Influence of some beta-adrenoceptor antagonists on the anticonvulsant potency of antiepileptic drugs against audiogenic seizures in DBA/2 mice. European journal of pharmacology 20020510
Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations. Chirality 20020505
Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents. The New England journal of medicine 20020502
The influence of first pass metabolism on the development and validation of an IVIVC for metoprolol extended release tablets. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20020501
Prognostic implications of autonomic function assessed by analyses of catecholamines and heart rate variability in stable angina pectoris. Heart (British Cardiac Society) 20020501
Novel use of a short-acting intravenous beta blocker in combination with inotropic therapy as a bridge to chronic oral beta blockade in patients with advanced heart failure. Clinical cardiology 20020501
A randomized and controlled pilot trial of beta-blockers for the treatment of recurrent syncope in patients with a positive or negative response to head-up tilt test. Pacing and clinical electrophysiology : PACE 20020501
Novel metrics to compare dissolution profiles. Pharmaceutical development and technology 20020501
Another possible treatment for protein-losing enteropathy. Cardiology in the young 20020501
Comparison of effects of carvedilol versus metoprolol on cytokine levels in patients with idiopathic dilated cardiomyopathy. The American journal of cardiology 20020415
Beta-blockers work as well in women as in men. Report on medical guidelines & outcomes research 20020405
Metoprolol CR/XL in female patients with heart failure: analysis of the experience in Metoprolol Extended-Release Randomized Intervention Trial in Heart Failure (MERIT-HF). Circulation 20020402
Dobutamine stress echocardiography for the detection of myocardial viability in patients with left ventricular dysfunction taking beta blockers: accuracy and optimal dose. Heart (British Cardiac Society) 20020401
The enhanced plasma levels of soluble tumor necrosis factor receptors (sTNF-R1; sTNF-R2) and interleukin-10 (IL-10) in patients suffering from chronic heart failure are reversed in patients treated with beta-adrenoceptor antagonist. Autonomic & autacoid pharmacology 20020401
Tolerability of beta-blocker initiation and titration in the Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure (MERIT-HF). Circulation 20020312
Exercise-induced, persistent and generalized muscle cramps. A case report. The Journal of sports medicine and physical fitness 20020301
Beta-blockers in chronic heart failure. European heart journal 20020301
Bucindolol exerts agonistic activity on the propranolol-insensitive state of beta1-adrenoceptors in human myocardium. The Journal of pharmacology and experimental therapeutics 20020301
Hidden danger of generic medications. Mayo Clinic proceedings 20020301
Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20020301
Reimbursement claims analysis of outcomes with carvedilol and metoprolol. The Annals of pharmacotherapy 20020301
Unique effects of carvedilol on noradrenaline release in the human heart. European journal of heart failure 20020301
Evaluation of USP apparatus 3 for dissolution testing of immediate-release products. AAPS pharmSci 20020301
High density-lipoprotein subfractions of patients using cardio-selective beta-blockers. Cardiovascular drugs and therapy 20020301
Acute delirium induced by metoprolol. Cardiovascular drugs and therapy 20020301
[Effects of metoprolol on the signal averaged electrocardiogram and QT dispersion in acute myocardial infarction]. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20020301
Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. Circulation 20020226
Effectiveness of preprinted order forms in promoting perioperative beta-blocker use. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20020215
Effect of controlled release/extended release metoprolol on carotid intima-media thickness in patients with hypercholesterolemia: a 3-year randomized study. Stroke 20020201
Catecholamine stimulation is associated with impaired myocardial O(2) utilization in heart failure. Cardiovascular research 20020201
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. Schmerz (Berlin, Germany) 20020201
Effects of metoprolol CR/XL on mortality and hospitalizations in patients with heart failure and history of hypertension. Journal of cardiac failure 20020201
Enantioselective stabilization of inclusion complexes of metoprolol in carboxymethylated beta-cyclodextrin. Journal of pharmaceutical and biomedical analysis 20020115
Longitudinal myocardial contraction improves early during titration with metoprolol CR/XL in patients with heart failure. Heart (British Cardiac Society) 20020101
Exacerbation of variant angina by metoprolol resulting in syncope due to transient atrioventricular block. International journal of cardiology 20020101
Highlights of latest American College of Cardiology and American Heart Association Guidelines for Management of Patients with Acute Myocardial Infarction. Cardiology in review 20020101
Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock. Pharmacology, biochemistry, and behavior 20020101
Neurohormonal activation in heart failure after acute myocardial infarction treated with beta-receptor antagonists. European journal of heart failure 20020101
The African-specific CYP2D617 allele encodes an enzyme with changed substrate specificity. Clinical pharmacology and therapeutics 20020101
Cardiovascular effects of beta-blockers with and without intrinsic sympathomimetic activity. A comparison between celiprolol and metoprolol. Kidney & blood pressure research 20020101
[Prospects of use of the combined preparation logimax in patients with essential hypertension]. Terapevticheskii arkhiv 20020101
[Effect of beta-blockers on the cardiac rhythm variability in patients with hypertension]. Likars'ka sprava 20020101
Metoprolol treatment to prevent restenosis following percutaneous transluminal coronary angioplasty. Cardiology 20020101
Inhibition of beta-1 receptor but not vagotomy can abolish the L-NAME evoked bradycardia in anesthetized rat. Physiological research 20020101
Liquid chromatography/tandem mass spectrometric bioanalysis using normal-phase columns with aqueous/organic mobile phases - a novel approach of eliminating evaporation and reconstitution steps in 96-well SPE. Rapid communications in mass spectrometry : RCM 20020101
Reliability and efficacy of metoprolol and diltiazem in patients having mild to moderate mitral stenosis with sinus rhythm. Angiology 20020101
Should beta-blockers be used for the treatment of pediatric patients with chronic heart failure? Paediatric drugs 20020101
Beta-blocker-induced psoriasis: a rare side effect--a case report. Angiology 20020101
[The use of combination therapy with lacidipine and beta-adrenoblockers in patients with hypertension]. Kardiologiia 20020101
[Changes of distensibility of the aorta in elderly patients during long-term therapy with various classes of hypotensive drugs (magnetic resonance tomography data)]. Kardiologiia 20020101
[Complex assessment of efficacy and tolerance of metoprolol CR/ZOK in treating hypertension]. Terapevticheskii arkhiv 20020101
[Stability of neurohumoral effects of losartan combined with metoprolol in chronic cardiac low output]. Likars'ka sprava 20020101
beta-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure. Circulation 20011204
Expression, purification, and biochemical characterization of a human cytochrome P450 CYP2D6-NADPH cytochrome P450 reductase fusion protein. Archives of biochemistry and biophysics 20011201
Combination treatment in stable effort angina using trimetazidine and metoprolol: results of a randomized, double-blind, multicentre study (TRIMPOL II). TRIMetazidine in POLand. European heart journal 20011201
Relationship between evaluation by quantitative fatty acid myocardial scintigraphy and response to beta-blockade therapy in patients with dilated cardiomyopathy. European journal of nuclear medicine 20011201
Growth hormone alone or combined with metoprolol preserves cardiac function after myocardial infarction in rats. European journal of heart failure 20011201
Do beta-adrenergic blocking agents increase coronary flow reserve? Journal of the American College of Cardiology 20011201
Effect of metoprolol and d,l-sotalol on microvolt-level T-wave alternans. Results of a prospective, double-blind, randomized study. Journal of the American College of Cardiology 20011201
Dose-related effects of metoprolol on heart rate and pharmacokinetics in heart failure. Journal of cardiac failure 20011201
Effects of beta-blockers on sexual performance in men with coronary heart disease. A prospective, randomized and double blinded study. International journal of impotence research 20011201
Lack of evidence for peripheral alpha(1)- adrenoceptor blockade during long-term treatment of heart failure with carvedilol. Journal of the American College of Cardiology 20011101
Comparative left ventricular functional and neurohumoral effects of chronic treatment with carvedilol versus metoprolol in patients with dilated cardiomyopathy. Japanese circulation journal 20011101
Assessment of cytochrome P450 activity by a five-drug cocktail approach. Clinical pharmacology and therapeutics 20011101
Absence of a morning peak in ventricular tachycardia and fibrillation events in nonischemic heart disease: analysis of therapies by implantable cardioverter defibrillators. Pacing and clinical electrophysiology : PACE 20011101
Nonselective versus selective beta-adrenergic receptor blockade in congestive heart failure: differential effects on sympathetic activity. Circulation 20011030
Diversity in mechanisms of substrate oxidation by cytochrome P450 2D6. Lack of an allosteric role of NADPH-cytochrome P450 reductase in catalytic regioselectivity. The Journal of biological chemistry 20011026
Acute precipitants of congestive heart failure exacerbations. Archives of internal medicine 20011022
Cocaine use and acute coronary syndromes. Lancet (London, England) 20011020
Reliability, validity, and responsiveness of the six-minute walk test in patients with heart failure. American heart journal 20011001
Effect of early treatment with captopril and metoprolol singly and together on postinfarction left ventricular remodeling. American heart journal 20011001
Metoprolol controlled release/extended release in patients with severe heart failure: analysis of the experience in the MERIT-HF study. Journal of the American College of Cardiology 20011001
Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure. Journal of the American College of Cardiology 20011001
Nightmares and sleep disturbances with simvastatin and metoprolol. The Annals of pharmacotherapy 20011001
Study of formulation parameters by factorial design in metoprolol tartrate matrix systems. Drug development and industrial pharmacy 20011001
[Comparative effects of carvedilol and metoprolol in preventing from left ventricular remodeling after acute myocardial infarction in rats]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20011001
[Role of beta-blockers in the treatment of chronic heart heart failure]. Orvosi hetilap 20010916
Emotional stress activates MAP kinase in the rat heart. Life sciences 20010907
Beneficial effect of beta-adrenergic blockade on left ventricular function in haemodialysis patients. Clinical science (London, England : 1979) 20010901
Challenges of subgroup analyses in multinational clinical trials: experiences from the MERIT-HF trial. American heart journal 20010901
Cost-effectiveness of beta-blocker therapy with metoprolol or with carvedilol for treatment of heart failure in Canada. American heart journal 20010901
Continuous beds with vancomycin as chiral stationary phase for capillary electrochromatography. Electrophoresis 20010901
What is the best treatment for slowing the progression to end-stage renal disease (ESRD) in African Americans with hypertensive nephropathy? The Journal of family practice 20010901
Metoprolol-induced changes in myocardial (123)I-metaiodobenzylguanidine uptake in Parkinson's disease. Circulation 20010814
Nebivolol, bucindolol, metoprolol and carvedilol are devoid of intrinsic sympathomimetic activity in human myocardium. British journal of pharmacology 20010801
Are all beta-blockers equally effective in reducing mortality after acute myocardial infarction (AMI)? The Journal of family practice 20010801
Effect of metoprolol CR/XL on exercise tolerance in chronic heart failure - a substudy to the MERIT-HF trial. European journal of heart failure 20010801
Enantiomeric separation of metoprolol and alpha-hydroxymetoprolol by liquid chromatography and fluorescence detection using a chiral stationary phase. Journal of chromatography. B, Biomedical sciences and applications 20010715
beta(1)-Adrenoceptor antibodies induce positive inotropic response in isolated cardiomyocytes. European journal of pharmacology 20010706
Statistical issues relating to international differences in clinical trials. American heart journal 20010701
Influence of beta-adrenoceptor antagonists on the pharmacokinetics of rizatriptan, a 5-HT1B/1D agonist: differential effects of propranolol, nadolol and metoprolol. British journal of clinical pharmacology 20010701
Diabetics with hypertension not controlled with ACE inhibitors: alternate therapies. Angiology 20010701
Possible mechanism of regression of myocardial hypertrophy. Bulletin of experimental biology and medicine 20010701
Behavioral-independent features of complex heartbeat dynamics. Physical review letters 20010625
Metoprolol attenuates postischemic depressed myocardial function in papillary muscles isolated from normal and postinfarction rat hearts. European journal of pharmacology 20010622
Nebivolol, carvedilol and metoprolol do not influence cardiac Ca(2+) sensitivity. European journal of pharmacology 20010622
Cardiac autonomic denervation and functional response to neurotoxins during acute experimental Chagas' disease in rats. Autonomic neuroscience : basic & clinical 20010620
Beta-blockade in chronic heart failure. Circulation 20010612
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA 20010606
Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis. American heart journal 20010601
Differing beta-blocking effects of carvedilol and metoprolol. European journal of heart failure 20010601
Circadian variation of heart rate variability and the rate of autonomic change in the morning hours in healthy subjects and angina patients. International journal of cardiology 20010601
Beta-blockers to reduce mortality in patients with systolic dysfunction: a meta-analysis. The Journal of family practice 20010601
The juxtaglomerular apparatus in young type-1 diabetic patients with microalbuminuria. Effect of antihypertensive treatment. Virchows Archiv : an international journal of pathology 20010601
Economic impact of beta blockade in heart failure. The American journal of medicine 20010507
Enantioselective determination of metoprolol and major metabolites in human urine by capillary electrophoresis. Journal of chromatography. B, Biomedical sciences and applications 20010505
Metoprolol-paroxetine interaction in human liver microsomes: stereoselective aspects and prediction of the in vivo interaction. Drug metabolism and disposition: the biological fate of chemicals 20010501
Angerlike behavioral state potentiates myocardial ischemia-induced T-wave alternans in canines. Journal of the American College of Cardiology 20010501
Metoprolol CR/XL in the treatment of chronic heart failure. Pharmacotherapy 20010501
An optimized methodology for combined phenotyping and genotyping on CYP2D6 and CYP2C19. European journal of clinical pharmacology 20010501
Effects of direct sympathetic and vagus nerve stimulation on the physiology of the whole heart--a novel model of isolated Langendorff perfused rabbit heart with intact dual autonomic innervation. Experimental physiology 20010501
Influence of phenylalanine-481 substitutions on the catalytic activity of cytochrome P450 2D6. The Biochemical journal 20010415
Low-dose metoprolol CR/XL and fluvastatin slow progression of carotid intima-media thickness: Main results from the Beta-Blocker Cholesterol-Lowering Asymptomatic Plaque Study (BCAPS). Circulation 20010403
Comparative effects of three beta blockers (atenolol, metoprolol, and propranolol) on survival after acute myocardial infarction. The American journal of cardiology 20010401
Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload: effects of beta-receptor blockade. Journal of molecular and cellular cardiology 20010301
Effect of metoprolol on cytokine levels in chronic heart failure--a substudy in the Metoprolol Controlled-Release Randomised Intervention Trial in Heart Failure (MERIT-HF). American heart journal 20010301
Does acute-phase beta blockade reduce left atrial appendage function in patients with chronic nonvalvular atrial fibrillation? Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 20010301
A preliminary study of beta-cyclodextrin/metoprolol tartrate inclusion complex for potential enantiomeric separation. Journal of pharmaceutical and biomedical analysis 20010301
Effect of beta blockers on mortality and morbidity in persons treated for congestive heart failure. Journal of the American Geriatrics Society 20010301
Anti beta1-adrenoceptor autoantibodies analyzed in spontaneously beating neonatal rat heart myocyte cultures-comparison of methods. In vitro cellular & developmental biology. Animal 20010301
[Adrenergic beta inhibitors in heart insufficiency: which and when?]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20010301
A comparative study of oral acetylsalicyclic acid and metoprolol for the prophylactic treatment of migraine. A randomized, controlled, double-blind, parallel group phase III study. Cephalalgia : an international journal of headache 20010301
[Study on sampling preconcentration method combining electrostacking with isotachophoresis in capillary electrophoresis]. Se pu = Chinese journal of chromatography 20010301
Selective beta(1)-blockade improves cardiac bioenergetics and function and decreases neuroendocrine activation in rats during early postinfarct remodeling. Biochemical and biophysical research communications 20010223
Hyperthyroid dementia: clinicoradiological findings and response to treatment. Journal of the neurological sciences 20010215
Differential effects of carvedilol and metoprolol on isoprenaline-induced changes in beta-adrenoceptor density and systolic function in rat cardiac myocytes. Cardiovascular research 20010201
Effects of nebivolol on proliferation and apoptosis of human coronary artery smooth muscle and endothelial cells. Cardiovascular research 20010201
Asymptomatic atrial fibrillation: problems of management. Chest 20010201
Effect of metoprolol on rest and exercise left ventricular systolic and diastolic function in idiopathic dilated cardiomyopathy. American heart journal 20010201
Sevelamer hydrochloride (Renagel), a phosphate-binding polymer, does not alter the pharmacokinetics of two commonly used antihypertensives in healthy volunteers. Journal of clinical pharmacology 20010201
Effect of beta-blockers on circulating levels of inflammatory and anti-inflammatory cytokines in patients with dilated cardiomyopathy. Journal of the American College of Cardiology 20010201
Origins of heart rate variability: autonomic blockade of large magnitude, transient bradycardia in conscious rabbits. The Canadian journal of cardiology 20010201
On glomerular structural alterations in type-1 diabetes. Companions of early diabetic glomerulopathy. Virchows Archiv : an international journal of pathology 20010201
Metoprolol-induced functional benefit in dilated cardiomyopathy is sustained over four years and favorably influences outcome. Italian heart journal : official journal of the Italian Federation of Cardiology 20010201
Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin. Electrophoresis 20010201
Anti-ischaemic efficacy and tolerability of trimetazidine administered to patients with angina pectoris: results of three studies. Coronary artery disease 20010201
Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris. European heart journal 20010101
Oxygen consumption in patients with hyperthyroidism before and after treatment with beta-blockade versus thyrostatic treatment: a prospective randomized study. Annals of surgery 20010101
Antioxidant properties of carvedilol and metoprolol in heart failure: a double-blind randomized controlled trial. Journal of cardiovascular pharmacology 20010101
Autonomic dysfunction in patients with mild heart failure and coronary artery disease and the effects of add-on beta-blockade. European journal of heart failure 20010101
Silent ischemic interval on exercise test is a predictor of response to drug therapy: a randomized crossover trial of metoprolol versus diltiazem in stable angina. Clinical cardiology 20010101
How to manage atrial fibrillation: an update on recent clinical trials. Cardiology in review 20010101
[In vitro permeability studies as a substitute for in vivo studies--which requirements have to be met?]. ALTEX 20010101
Acute renal ischemia model in dogs: effects of metoprolol. Renal failure 20010101
Sotalol vs metoprolol for ventricular rate control in patients with chronic atrial fibrillation who have undergone digitalization: a single-blinded crossover study. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20010101
Effects of digoxin, furosemide, enalaprilat and metoprolol on endothelial function in young normotensive subjects. Clinical and experimental pharmacology & physiology 20010101
Stereospecific pharmacokinetics and pharmacodynamics of beta-adrenergic blockers in humans. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20010101
Regression of left ventricular mass with captopril and metoprolol, and the effects on glucose and lipid metabolism. Blood pressure 20010101
The African American Study of Kidney Disease and Hypertension (AASK): new findings. Journal of clinical hypertension (Greenwich, Conn.) 20010101
[Effects of nebivolol, metoprolol and enalapril maleate on the state of endothelium-dependent arteriolar vasodilation in patients with essential hypertension]. Likars'ka sprava 20010101
Blacks with hypertension, renal insufficiency, and baseline proteinuria benefit more from ACE inhibition than from calcium channel blockade. Journal of clinical hypertension (Greenwich, Conn.) 20010101
Beta-blockers in heart failure. Bratislavske lekarske listy 20010101
Development and validation of a chiral liquid chromatographic method for the determination of atenolol and metoprolol enantiomers in tablet preparations. Journal of AOAC International 20010101
Ischemic and reperfusive release of the endogenous purines and its influence on the myocardial viability during beta-adrenergic blockade. Polish journal of pharmacology 20010101
Rationale, design and organization of the Second Chinese Cardiac Study (CCS-2): a randomized trial of clopidogrel plus aspirin, and of metoprolol, among patients with suspected acute myocardial infarction. Second Chinese Cardiac Study (CCS-2) Collaborative Group. Journal of cardiovascular risk 20001201
Atrial fibrillation occurring in a patient taking etanercept plus methotrexate for rheumatoid arthritis. Delaware medical journal 20001201
Effect of intravenous metoprolol or intravenous metoprolol plus glucagon on dobutamine-induced myocardial ischemia. Pharmacotherapy 20001101
Beta-blockade in adriamycin-induced cardiomyopathy. Journal of cardiac failure 20000601
Side effects of beta-blocker treatment for hypertension. Scandinavian journal of primary health care 20000601
beta-adrenergic blockade in developing heart failure: effects on myocardial inflammatory cytokines, nitric oxide, and remodeling. Circulation 20000502
MERIT-HF mortality and morbidity data. Basic research in cardiology 20000101
Attenuation of catecholamine-induced immunosuppression in whole blood from patients with sepsis. Shock (Augusta, Ga.) 19991201
Beta-blockade in heart failure: a comparison of carvedilol with metoprolol. Journal of the American College of Cardiology 19991101
[Ticlopidine-induced cholestasis]. Schweizerische medizinische Wochenschrift 19991002
Effect of beta-blockers on free radical-induced cardiac contractile dysfunction. Circulation 19990727
Comparison of intravenous metoprolol, verapamil and diltiazem on the attenuation of haemodynamic changes associated with tracheal extubation. European journal of anaesthesiology 19990701
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF). Lancet (London, England) 19990612
Effects of beta-receptor blockade and angiotensin II type I receptor antagonism in isoproterenol-induced heart failure in the rat. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 19990101
An unusual toxic reaction to axillary block by mepivacaine with adrenaline. Acta anaesthesiologica Scandinavica 19980801
Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy. International journal of clinical pharmacology and therapeutics 19980801
Endothelin converting-enzyme-1 mRNA expression in human cardiovascular disease. Clinical and experimental hypertension (New York, N.Y. : 1993) 19980501
Treatment of milrinone-associated tachycardia with beta-blockers. Canadian journal of anaesthesia = Journal canadien d'anesthesie 19980101
How long should pindolol be associated with paroxetine to improve the antidepressant response? Journal of clinical psychopharmacology 19971201
Role of sympathetic nerves for the stimulation of the renin system by angiotensin II receptor blockade. Journal of hypertension 19971201
Beta blockade in congestive heart failure: persistent adverse haemodynamic effects during chronic treatment with subsequent doses. Heart (British Cardiac Society) 19971101
Role of central nicotinic and beta-adrenergic receptors in the onset and further development of tail-tremor induced by repeated nicotine administration to rats. Naunyn-Schmiedeberg's archives of pharmacology 19970501
Effect of beta 1 adrenergic receptor blockade on myocardial blood flow and vasodilatory capacity. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 19970301
Effects of selective beta-adrenoceptor antagonists on gastric ulceration in the rat. The Journal of pharmacy and pharmacology 19970201
Comparative hemodynamic, left ventricular functional, and antiadrenergic effects of chronic treatment with metoprolol versus carvedilol in the failing heart. Circulation 19961201
Response to beta blockers in patients with neurocardiogenic syncope: how to predict beneficial effects. Journal of cardiovascular electrophysiology 19961201
[Bradycardia after beginning therapy with metoprolol and paroxetine]. Psychiatrische Praxis 19960901
Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: the carvedilol-metoprolol study. Journal of hypertension 19960401
[Cardiogenic shock and ventricular fibrillation induced by prajmalium and metoprolol poisoning]. Orvosi hetilap 19960331
Association of metoprolol and retroperitoneal fibrosis. American heart journal 19960101
A comparison of the effect of enalapril and metoprolol on renal function, potassium balance, lipid profile, cardiac function, exercise tolerance and quality of life in hypertensive dialysis patients. The International journal of artificial organs 19951201
[Long-term selective beta 1-blockade therapy for a patient with anthracycline-induced cardiomyopathy]. [Rinsho ketsueki] The Japanese journal of clinical hematology 19951101
[Akinetic mutism in decompensated triventricular hydrocephalus]. Fortschritte der Neurologie-Psychiatrie 19950601
Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report. Angiology 19950601
[Increased vagal activity after administration of the calcium antagonist diltiazem in patients with coronary heart disease]. Zeitschrift fur Kardiologie 19950201
Efficacy and safety of metoprolol in the treatment of doxorubicin-induced cardiomyopathy in pediatric patients. American heart journal 19950101
Addition of urapidil or metoprolol to the treatment of hypertensive non-responders to nifedipine monotherapy: efficacy and metabolic effects. Italian Urapidil Study Group. Blood pressure. Supplement 19950101
Portal-systemic encephalopathy and gastrointestinal bleeding after cardioselective beta-blocker (metoprolol) administration to patients with portal hypertension. Archives of medical research 19950101
Angioedema following the intravenous administration of metoprolol. Chest 19941201
Metoprolol: a pharmacoeconomic and quality-of-life evaluation of its use in hypertension, post-myocardial infarction and dilated cardiomyopathy. PharmacoEconomics 19941001
Role of renal nerves for the expression of renin in adult rat kidney. The American journal of physiology 19940501
Asystole and bradycardia during dipyridamole stress testing in patients receiving beta blockers. International journal of cardiology 19931101
Obesity as a determinant for response to antihypertensive treatment. BMJ (Clinical research ed.) 19930828
Effect of enoximone alone and in combination with metoprolol on myocardial function and energetics in severe congestive heart failure: improvement in hemodynamic and metabolic profile. Cardiovascular drugs and therapy 19930601
Cost-effectiveness of antihypertensive treatment: metoprolol versus thiazide diuretics. PharmacoEconomics 19930101
Effects of norepinephrine on the oxidative pentose phosphate pathway in the rat heart. Circulation research 19920801
Effectiveness of antihypertensive medications in office and ambulatory settings: a placebo-controlled comparison of atenolol, metoprolol, chlorthalidone, verapamil, and an atenolol-chlorthalidone combination. Journal of clinical pharmacology 19920601
Receptor pharmacology of carvedilol in the human heart. Journal of cardiovascular pharmacology 19920101
Metoprolol-induced delirium perpetuated by propafenone. American family physician 19911001
Efficacy of cardioselective beta-adrenergic blockade with intravenously administered metoprolol in the treatment of supraventricular tachyarrhythmias. Journal of clinical pharmacology 19910801
Effects of acute cardioselective and non-selective beta-adrenergic blockade on left-ventricular volumes and vascular resistance at rest and during exercise. Scandinavian journal of clinical and laboratory investigation 19910401
Chronic effects of metoprolol on myocardial beta-adrenergic receptors in doxorubicin-induced cardiac damage in rats. Journal of cardiovascular pharmacology 19910401
Debrisoquine phenotype and the pharmacokinetics and beta-2 receptor pharmacodynamics of metoprolol and its enantiomers. The Journal of pharmacology and experimental therapeutics 19910301
Effect of metoprolol on activity of beta-adrenoceptor coupled to guanine nucleotide binding regulatory proteins in adriamycin-induced cardiotoxicity. Basic research in cardiology 19910101
Early treatment with thrombolysis and beta-blockade in suspected acute myocardial infarction: results from the TEAHAT Study. Journal of internal medicine. Supplement 19910101
Confusing messages from the newest of the beta-blocker/diuretic hypertension trials. The Metoprolol Atherosclerosis Prevention in Hypertensives trial. Archives of internal medicine 19891001
Early treatment with intravenous metoprolol for suspected acute myocardial infarction: a phase IV United States trial. Phase IV Metoprolol in Myocardial Infarction Study Group. International journal of cardiology 19890501
A nonsteady-state agonist antagonist interaction model using plasma potassium concentrations to quantify the beta-2 selectivity of beta blockers. The Journal of pharmacology and experimental therapeutics 19890401
Bradycardia induced by an interaction between phenelzine and beta blockers. Psychosomatics 19890101
Primary prevention in patients with hypertension: comments on the clinical implications of the MAPHY Study. Metoprolol Atherosclerosis Prevention in Hypertensives Study. American heart journal 19880701
Beta-blocker effects on sexual function in normal males. Archives of sexual behavior 19880601
[Possibilities and limitations of selective beta 1 adrenergic receptor blockade in clinical practice]. Terapevticheskii arkhiv 19880101
A double-blind comparison of felodipine and hydrochlorothiazide added to metoprolol to control hypertension. European journal of clinical pharmacology 19880101
Efficacy and tolerability of a new controlled-release formulation of metoprolol: a comparison with conventional metoprolol tablets in mild to moderate hypertension. European journal of clinical pharmacology 19880101
Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. Klinische Wochenschrift 19871215
Prejunctional beta 2-adrenoreceptor blockade reduces nerve stimulation evoked release of endogenous noradrenaline in skeletal muscle in situ. Acta physiologica Scandinavica 19870401
Rebound hypertension following abrupt cessation of clonidine and metoprolol. Treatment with labetalol. Archives of internal medicine 19870201
Circadian antihypertensive profile of carvedilol (BM 14190). Journal of cardiovascular pharmacology 19870101
Effect of carvedilol and metoprolol on blood pressure, blood flow, and vascular resistance. Journal of cardiovascular pharmacology 19870101
Antihypertensive treatment in elderly hypertensives: implications of the MEHP study. Journal of cardiovascular pharmacology 19870101
Depressed melatonin secretion in patients with nightmares due to beta-adrenoceptor blocking drugs. Acta medica Scandinavica 19870101
EEG assessment of the sedative and excitatory properties of CNS-active compounds in the patients with depression. Neuropsychobiology 19870101
Early treatment of unstable angina in the coronary care unit: a randomised, double blind, placebo controlled comparison of recurrent ischaemia in patients treated with nifedipine or metoprolol or both. Report of The Holland Interuniversity Nifedipine/Metoprolol Trial (HINT) Research Group. British heart journal 19861101
Nephrotic-range proteinuria and hyperglycemia associated with clonidine therapy. The American journal of medicine 19860301
Haemodynamic analysis of the effects of nicardipine and metoprolol alone and in combination in coronary artery disease. European heart journal 19851101
Improvement in symptoms and exercise tolerance by metoprolol in patients with dilated cardiomyopathy: a double-blind, randomized, placebo-controlled trial. Circulation 19850901
Acute hemodynamic effects of pinacidil and hydralazine in essential hypertension. Clinical pharmacology and therapeutics 19850301
[Cardiogenic shock caused by metoprolol poisoning. Reversibility with high doses of glucagon and isoproterenol]. Presse medicale (Paris, France : 1983) 19850202
Beta blockade and intermittent claudication. Acta medica Scandinavica. Supplementum 19850101
CNS-related side-effects with metoprolol and atenolol. European journal of clinical pharmacology 19850101
Beta blockers and loss of hearing. British medical journal (Clinical research ed.) 19841201
Probable adverse interaction between oral metoprolol and verapamil. Postgraduate medical journal 19841001
[Paroxysmal diplopia from beta-blockers. Apropos of a case from metoprolol]. Presse medicale (Paris, France : 1983) 19840901
Development of congestive heart failure after treatment with metoprolol in acute myocardial infarction. British heart journal 19840501
Comparison of metoprolol and propranolol in the treatment of lithium tremor. Psychiatry research 19840201
The effect on left ventricular performance of nifedipine and metoprolol singly and together in exercise-induced angina pectoris. European heart journal 19840101
Effect of adrenergic stimulation and blockade on ventricular defibrillation in the rat. The Journal of pharmacology and experimental therapeutics 19831201
Successful treatment of supraventricular tachycardia with metoprolol, a cardioselective beta blocker. Clinical pediatrics 19830701
Acute myocardial ischaemia: what information can be expected in the near future from ongoing clinical trials with nifedipine? European heart journal 19830501
Treatment of lithium tremor with metoprolol. The American journal of psychiatry 19830501
A comparison between atenolol and metoprolol in respect of central nervous system side effects. Postgraduate medical journal 19830301
Ambulatory blood pressure during once-daily randomised double-blind administration of atenolol, metoprolol, pindolol, and slow-release propranolol. British medical journal (Clinical research ed.) 19821113
Relation of cardiovascular response to the hypotensive effect of metoprolol. American heart journal 19821001
Intranasally administered phenylephrine and blood pressure. Canadian Medical Association journal 19820901
Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases. Australian and New Zealand journal of medicine 19820801
Metoprolol in hypertension: an open evaluation. The Medical journal of Australia 19820123
Relevance of selectivity and non-selectivity in beta-adrenoceptor blocking drugs. British journal of clinical pharmacology 19820101
Peripheral vasospasm during beta-receptor blockade - a comparison between metoprolol and pindolol. Acta medica Scandinavica. Supplementum 19820101
Effects of treatment with nifedipine and metoprolol in essential hypertension. European journal of clinical pharmacology 19820101
Haemodynamic effects of metoprolol and pindolol: a comparison in hypertensive patients. British journal of clinical pharmacology 19820101
Metoprolol and pindolol in hypertension: different effects on peripheral haemodynamics. Clinical science (London, England : 1979) 19811201
Effect of atenolol, metoprolol, and propranolol on isoproterenol-induced tremor and tachycardia in normal subjects. Clinical pharmacology and therapeutics 19810401
The long-term ocular and systemic effects of topically applied metoprolol tartrate in glaucoma and ocular hypertension. Acta ophthalmologica 19810201
Adrenaline-induced hypertension in rats. Journal of cardiovascular pharmacology 19810101
Comparative study of hydrochlorothiazide and a fixed combination of metoprolol and hydrochlorothiazide essential hypertension. Annals of clinical research 19810101
A double-blind crossover comparative study of the efficacy of single daily doses of conventional and slow-release metoprolol. Current medical research and opinion 19810101
Haemodynamic dose-response effects of i.v. metoprolol in coronary heart disease. European journal of clinical pharmacology 19810101
[The antiarrhythmic effect of metoprolol (author's transl)]. Giornale italiano di cardiologia 19800101
A comparison of scalp tingling, thirst and polyuria in patients on labetalol and metoprolol. The New Zealand medical journal 19791114
Effects of adrenergic beta-blockers and a membrane stabilizing agent on ouabain-induced cardiac arrhythmias in anaesthetized guinea pigs. Acta pharmacologica et toxicologica 19790801
Once-daily metoprolol in primary hypertension. Clinical pharmacology and therapeutics 19790401
Effect of selective and non-selective beta-adrenoreceptor blockade on calf blood flow in hypertensive patients. Clinical science and molecular medicine. Supplement 19781201
An open study of the antihypertensive efficacy of metoprolol. The Medical journal of Australia 19780729
Peripheral gangrene complicating beta-blockade. Lancet (London, England) 19780603
Tremor caused by sympathomimetics is mediated by beta2-adrenoreceptors. Scandinavian journal of respiratory diseases 19770101
Assessment of metoprolol, a cardioselective beta-blocking agent, during chronic therapy in patients with angina pectoris. The Journal of international medical research 19760101
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