Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.

Journal of medicinal chemistry 20130613

The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Antimicrobial agents and chemotherapy 20130501

On dihydroorotate dehydrogenases and their inhibitors and uses.

Journal of medicinal chemistry 20130425

Quinolone-3-diarylethers: a new class of antimalarial drug.

Science translational medicine 20130320

4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

Antimicrobial agents and chemotherapy 20130101

A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs.

Malaria journal 20130101

Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Proceedings of the National Academy of Sciences of the United States of America 20121226

New naphthoquinones and an alkaloid with in vitro activity against Toxoplasma gondii RH and EGS strains.

Experimental parasitology 20121201

Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group.

Parasitology international 20120901

A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax.

The Journal of infection 20120901

Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin.

Veterinary parasitology 20120608

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

Journal of medicinal chemistry 20120510

Characterization of Plasmodium liver stage inhibition by halofuginone.

ChemMedChem 20120501

Standby emergency treatment of malaria in travelers: experience to date and new developments.

Expert review of anti-infective therapy 20120501

Development of in vitro atovaquone-resistant Babesia gibsoni with a single-nucleotide polymorphism in cytb.

Veterinary parasitology 20120430

Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug.

The Journal of infectious diseases 20120415

Dosing rationale for fixed-dose combinations in children: shooting from the hip?

Clinical pharmacology and therapeutics 20120401

Bridging strategies for drug combinations in pediatric indications.

Clinical pharmacology and therapeutics 20120401

Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

The Journal of biological chemistry 20120323

Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

Journal of medicinal chemistry 20120308

Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

Journal of medicinal chemistry 20120308

Anti-malarial chemoprophylaxis following evacuation from Afghanistan.

Journal of the Royal Army Medical Corps 20120301

Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120115

Randomized, prospective, three-arm study to confirm the auditory safety and efficacy of artemether-lumefantrine in Colombian patients with uncomplicated Plasmodium falciparum malaria.

The American journal of tropical medicine and hygiene 20120101

Atovaquone versus trimethoprim-sulfamethoxazole as Pneumocystis jirovecii pneumonia prophylaxis following renal transplantation.

Clinical transplantation 20120101

The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.

Malaria journal 20120101

Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.

Malaria journal 20120101

A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.

PloS one 20120101

Atovaquone ameliorate gastrointestinal toxoplasmosis complications in a pregnancy model.

Medical science monitor : international medical journal of experimental and clinical research 20120101

[Mitochondria as targets of chemotherapy].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.

PloS one 20120101

Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Chemistry & biology 20111223

Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

Journal of medicinal chemistry 20111222

Cyclodextrin/poly(anhydride) nanoparticles as drug carriers for the oral delivery of atovaquone.

Biomedical microdevices 20111201

Review: Malaria chemoprophylaxis for travelers to Latin America.

The American journal of tropical medicine and hygiene 20111201

Malaria therapy in HIV: drug interactions between nevirapine and quinine.

International journal of STD & AIDS 20111201

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

PLoS computational biology 20111201

[Atovaquone-proguanil treatment failure in Plasmodium falciparum].

Presse medicale (Paris, France : 1983) 20111101

Pharmacokinetics of antimalarials in pregnancy: a systematic review.

Clinical pharmacokinetics 20111101

Prophylactic use of antimalarials during pregnancy.

Canadian family physician Medecin de famille canadien 20111101

Synthetic chromanol derivatives and their interaction with complex III in mitochondria from bovine, yeast, and Leishmania.

Chemical research in toxicology 20111017

Sensitivity of Plasmodium vivax to chloroquine, mefloquine, artemisinin and atovaquone in north-western Thailand.

Wiener klinische Wochenschrift 20111001

Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Eukaryotic cell 20110801

Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n=3' or 4') against Plasmodium falciparum in in vitro models.

Bioorganic & medicinal chemistry letters 20110801

[Diagnosis and treatment of pneumocystis jirovecii pneumonia].

Deutsche medizinische Wochenschrift (1946) 20110701

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

Journal of medicinal chemistry 20110609

Community management of anti-malarials in Africa and iatrogenic risk.

Journal of tropical pediatrics 20110601

Persistent babesiosis in a stem cell transplant recipient.

Leukemia research 20110601

Diagnostic and therapeutic challenges.

Retina (Philadelphia, Pa.) 20110601

Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Molecular and biochemical parasitology 20110501

Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.

Antimicrobial agents and chemotherapy 20110401

Babesiosis in an Egyptian boy aquired from pet dog, and a general review.

Journal of the Egyptian Society of Parasitology 20110401

Azithromycin for treating uncomplicated malaria.

The Cochrane database of systematic reviews 20110216

Atovaquone-proguanil use in early pregnancy and the risk of birth defects.

Archives of internal medicine 20110214

SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood-brain barriers.

Journal of drug targeting 20110201

Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs.

Experimental parasitology 20110101

[Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment].

Medecine et maladies infectieuses 20110101

Toxoplasma gondii primary infection in renal transplant recipients. Two case reports and literature review.

Transplant international : official journal of the European Society for Organ Transplantation 20110101

Efficacy of atovaquone and azithromycin or imidocarb dipropionate in cats with acute cytauxzoonosis.

Journal of veterinary internal medicine 20110101

A potential interaction between warfarin and atovaquone.

The Annals of pharmacotherapy 20110101

Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.

Malaria journal 20110101

Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.

Malaria journal 20110101

Pneumocystis carinii pneumonia prophylaxis: current therapies and recommendations.

Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20110101

Resolution of a proteinuric nephropathy associated with Babesia gibsoni infection in a dog.

Journal of the American Animal Hospital Association 20110101

Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.

Antimicrobial agents and chemotherapy 20101201

Antimalarial drugs: modes of action and mechanisms of parasite resistance.

Future microbiology 20101201

Combination of chiroptical, absorption and fluorescence spectroscopic methods reveals multiple, hydrophobicity-driven human serum albumin binding of the antimalarial atovaquone and related hydroxynaphthoquinone compounds.

Organic & biomolecular chemistry 20101107

Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion.

Molecular and biochemical parasitology 20101101

Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man.

The Pediatric infectious disease journal 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

Bioorganic & medicinal chemistry 20101101

Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

Journal of medicinal chemistry 20101014

Computer-assisted design of pro-drugs for antimalarial atovaquone.

Chemical biology & drug design 20101001

Spiroindolones, a potent compound class for the treatment of malaria.

Science (New York, N.Y.) 20100903

Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Antimicrobial agents and chemotherapy 20100901

Babesiosis in a patient on infliximab for Crohn's disease.

Inflammatory bowel diseases 20100801

Does atovaquone prolong the disease-free interval of toxoplasmic retinochoroiditis?

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20100801

Inhibiting Plasmodium cytochrome bc1: a complex issue.

Current opinion in chemical biology 20100801

Evaluation and structure-activity relationship study of acute toxicity of naphthoquinones to Photobacterium phosphoreum, Photobacterium T3B.

Bulletin of environmental contamination and toxicology 20100801

Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

AIDS (London, England) 20100515

LC-APCI mass spectrometric method development and validation for the determination of atovaquone in human plasma.

Biomedical chromatography : BMC 20100501

Letter to the editor of travel medicine and infectious disease.

Travel medicine and infectious disease 20100501

Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population.

Journal of evolutionary biology 20100301

Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100201

[Effects of combined addition of atovaquone and lithium on the in vitro cell growth of the pathogenic yeast Candida albicans].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100201

Congenital babesiosis in a four-week-old female infant.

The Pediatric infectious disease journal 20100201

Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones.

Biochimica et biophysica acta 20100101

Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency.

Scandinavian journal of infectious diseases 20100101

In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.

Antimicrobial agents and chemotherapy 20100101

Alternatives for malaria prophylaxis during the first trimester of pregnancy: our personal view.

Journal of travel medicine 20100101

Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction.

Malaria journal 20100101

Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene.

Malaria journal 20100101

Assessment of adherence to atovaquone-proguanil prophylaxis in travelers.

Journal of travel medicine 20100101

Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.

Malaria journal 20100101

Transfusion-associated babesiosis in a 7-month-old infant after bidirectional Glenn procedure.

Congenital heart disease 20100101

Babesiosis in the immediate postoperative period after splenectomy for trauma.

Surgical infections 20091201

Synthesis and antimalarial activity of new atovaquone derivatives.

European journal of medicinal chemistry 20091101

Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.

Travel medicine and infectious disease 20091101

Mefloquine has more adverse effects than other drugs for malaria prophylaxis.

BMJ (Clinical research ed.) 20091013

Drugs for preventing malaria in travellers.

The Cochrane database of systematic reviews 20091007

Plasmodium relictum (lineage P-SGS1): Further observation of effects on experimentally infected passeriform birds, with remarks on treatment with Malarone.

Experimental parasitology 20091001

Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090915

Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.

Bioorganic & medicinal chemistry letters 20090901

Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

Bioorganic & medicinal chemistry letters 20090701

Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children.

Prescrire international 20090601

The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis.

Journal of drug targeting 20090501

Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assays.

Rapid communications in mass spectrometry : RCM 20090501

Pneumocystis jirovecii pneumonia after rituximab therapy for antibody-mediated rejection in a renal transplant recipient.

Transplant infectious disease : an official journal of the Transplantation Society 20090401

Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro.

Journal of natural products 20090327

79-year-old man with fever, malaise, and jaundice.

Mayo Clinic proceedings 20090301

Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Bioorganic & medicinal chemistry letters 20090201

Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.

Journal of travel medicine 20090101

[Mutations of drug target molecules in Pneumocystis jirovecii isolates and future investigations].

Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

Possible emergence of drug-resistant variants of Babesia gibsoni in clinical cases treated with atovaquone and azithromycin.

Journal of veterinary internal medicine 20090101

Breakthrough cerebral toxoplasmosis in a patient receiving atovaquone prophylaxis after a hematopoietic stem cell transplantation.

Pediatric transplantation 20081201

Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.

Military medicine 20081201

Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.

Clinical therapeutics 20081101

Comparative genomics of the neglected human malaria parasite Plasmodium vivax.

Nature 20081009

Splenic pneumocystosis: an atypical presentation of extrapulmonary Pneumocystis infection.

The AIDS reader 20081001

Toxoplasmosis in wallabies (Macropus rufogriseus and Macropus eugenii): blindness, treatment with atovaquone, and isolation of Toxoplasma gondii.

The Journal of parasitology 20080801

Bullous erythema multiforme after treatment with Malarone, a combination antimalarial composed of atovaquone and proguanil hydrochloride.

Tropical doctor 20080701

Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b gene.

Parasitology international 20080601

Atovaquone-proguanil resistance in imported falciparum malaria in a young child.

The Pediatric infectious disease journal 20080601

Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.

Journal of medicinal chemistry 20080508

A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.

Molecular and biochemical parasitology 20080501

Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.

Molecular pharmacology 20080501

Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.

Travel medicine and infectious disease 20080501

Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.

Prescrire international 20080401

Atovaquone-statine 'double-drugs' with high antiplasmodial activity.

ChemMedChem 20080301

[Tolerance and efficacy of atovaquone-proguanil for the treatment of paediatric imported Plasmodium falciparum malaria in France: clinical practice in a university hospital in Paris].

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080301

[Babesiosis in an immunocompromised German patient].

Medizinische Klinik (Munich, Germany : 1983) 20080215

Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.

Emerging infectious diseases 20080201

Complications of coinfection with Babesia and Lyme disease after splenectomy.

Journal of the American Board of Family Medicine : JABFM 20080101

In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.

Malaria journal 20080101

Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.

Malaria journal 20080101

Fever of unknown origin (FUO) due to babesiosis in a immunocompetent host.

Heart & lung : the journal of critical care 20080101

Trends in antimalarial prescriptions in Australia 2002 to 2005.

Journal of travel medicine 20080101

Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil.

Malaria journal 20080101

HIV: treating Pneumocystis pneumonia (PCP).

BMJ clinical evidence 20080101

Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215

Inadequate chemoprophylaxis and the risk of malaria.

Australian family physician 20071201

Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

The American journal of tropical medicine and hygiene 20071201

Selective ambulatory management of Plasmodium falciparum malaria in paediatric refugees.

Archives of disease in childhood 20071101

A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria.

The Journal of antimicrobial chemotherapy 20071101

Babesia gibsoni: detection during experimental infections and after combined atovaquone and azithromycin therapy.

Experimental parasitology 20071001

Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.

Trends in parasitology 20071001

Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.

Bioorganic & medicinal chemistry letters 20070915

Drug-resistant malaria - an insight.

The FEBS journal 20070901

Clinical efficacy of antiparasite treatments against intestinal helminths and haematic protozoa in Gallotia caesaris (lizards).

Experimental parasitology 20070801

Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

Molecular biology and evolution 20070801

A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

Experimental parasitology 20070701

First case of human babesiosis in Germany - Clinical presentation and molecular characterisation of the pathogen.

International journal of medical microbiology : IJMM 20070601

Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases.

Antimicrobial agents and chemotherapy 20070401

Prevention and treatment of congenital toxoplasmosis.

Expert review of anti-infective therapy 20070401

Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.

The American journal of tropical medicine and hygiene 20070401

Cerebral malaria in spite of peripheral parasite clearance in a patient treated with atovaquone/proguanil.

Parasitology research 20070301

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

Experimental parasitology 20070301

Analyses of cytochrome b mutations in Plasmodium falciparum isolates in Thai-Myanmar border.

Travel medicine and infectious disease 20070301

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Nature 20070301

Molecular characterisation of Babesia gibsoni infection from a pit-bull terrier pup recently imported into South Africa.

Journal of the South African Veterinary Association 20070301

Motor neuron disease recovery associated with IV ceftriaxone and anti-Babesia therapy.

Acta neurologica Scandinavica 20070201

Atovaquone and azithromycin treatment for babesiosis in an infant.

The Pediatric infectious disease journal 20070201

Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).

The American journal of tropical medicine and hygiene 20070201

[New drugs against parasitic diseases].

La Revue du praticien 20070131

The traveling farm wife.

The American journal of medicine 20070101

The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].

Journal of travel medicine 20070101

A man with tropical travel history, fever, and pulmonary infiltrates.

Comprehensive therapy 20070101

Synergistic interaction between atovaquone and retinol in Plasmodium falciparum in vitro.

Wiener klinische Wochenschrift 20070101

Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum.

Wiener klinische Wochenschrift 20070101

Relapsing vivax malaria after 6 months of daily atovaquone/proguanil in Afghanistan: the case for expanded use of primaquine as a causal prophylactic.

Journal of travel medicine 20070101

Outpatient treatment of malaria in recently arrived African migrants.

The Medical journal of Australia 20061201

A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children.

Tropical medicine & international health : TM & IH 20061101

Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20061001

Babesiosis masquerading as recurrent immune thrombocytopenic purpura in a splenectomized patient.

Annals of hematology 20061001

Plasmodium falciparum malaria associated with mefloquine failure in Gambia.

Pharmacotherapy 20061001

Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061001

Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

Microbes and infection 20060901

Randomized, double-blind, placebo-controlled study of Malarone for malaria prophylaxis in non-immune Colombian soldiers.

The American journal of tropical medicine and hygiene 20060901

Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone.

The Journal of pharmacy and pharmacology 20060601

Folic acid treatment of Zambian children with moderate to severe malaria anemia.

The American journal of tropical medicine and hygiene 20060601

Reactivation of toxoplasma retinochoroiditis under atovaquone therapy in an immunocompetent patient.

Ocular immunology and inflammation 20060601

Pneumocystis pneumonia in people with HIV.

Clinical evidence 20060601

Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

European journal of clinical pharmacology 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis.

Microbes and infection 20060501

Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae.

Molecular and biochemical parasitology 20060401

Short report: cloning of the Babesia gibsoni cytochrome B gene and isolation of three single nucleotide polymorphisms from parasites present after atovaquone treatment.

The American journal of tropical medicine and hygiene 20060401

[Malaria: a medical and economic problem].

Presse medicale (Paris, France : 1983) 20060401

Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.

Acta tropica 20060301

Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

The Journal of antimicrobial chemotherapy 20060101

Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola.

Malaria journal 20060101

Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other treatment.

Advances in therapy 20060101

Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.

Malaria journal 20060101

Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.

Journal of travel medicine 20060101

Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and Ethiopia.

Malaria journal 20060101

Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro.

Wiener klinische Wochenschrift 20060101

Atovaquone/proguanil for the prophylaxis and treatment of malaria.

Expert review of anti-infective therapy 20051201

Malaria: prevention in travellers.

Clinical evidence 20051201

Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.

Experimental parasitology 20051101

[Ineffective change of antimalaria prophylaxis to Artemisia vulgaris in a group travelling to West Africa].

Ugeskrift for laeger 20051024

Atovaquone-proguanil for treating uncomplicated malaria.

The Cochrane database of systematic reviews 20051019

[Malaria chemoprophylaxis].

Ugeskrift for laeger 20051017

[Malaria prophylaxis for long-term travellers and expatriates].

Ugeskrift for laeger 20051017

The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.

European journal of clinical pharmacology 20050901

A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy.

The Journal of infectious diseases 20050901

Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050801

Ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of Pneumocystis spp.: differential sensitivities to atovaquone.

Eukaryotic cell 20050801

Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate.

The American journal of tropical medicine and hygiene 20050801

Effectiveness of antimalarial drugs.

The New England journal of medicine 20050728

Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.

The Journal of biological chemistry 20050722

Occult Plasmodium vivax infection diagnosed by a polymerase chain reaction-based detection system: a case report.

The American journal of tropical medicine and hygiene 20050701

Prediction of genotoxicity of chemical compounds by statistical learning methods.

Chemical research in toxicology 20050601

Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil.

Parasite (Paris, France) 20050601

Pneumocystis pneumonia in people with HIV.

Clinical evidence 20050601

Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.

Journal of medicinal chemistry 20050505

Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.

The Journal of biological chemistry 20050429

UDP-glucuronosyltransferases and clinical drug-drug interactions.

Pharmacology & therapeutics 20050401

Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa.

The American journal of tropical medicine and hygiene 20050401

Multiple cytochrome B mutations may cause atovaquone resistance.

The Journal of infectious diseases 20050301

Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.

Acta tropica 20050301

A randomized open label clinical trial to compare the efficacy and safety of intravenous quinine followed by oral malarone vs. intravenous quinine followed by oral quinine in the treatment of severe malaria.

Journal of tropical pediatrics 20050201

A malaria outbreak following a British military deployment to Sierra Leone.

The Journal of infection 20050201

In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20050101

Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050101

Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate.

Microbes and infection 20050101

Simultaneous quantitation of the highly lipophilic atovaquone and hydrophilic strong basic proguanil and its metabolites using a new mixed-mode SPE approach and steep-gradient LC.

Journal of chromatographic science 20050101

Malaria prophylaxis for aircrew: safety of atovaquone/proguanil in healthy volunteers under aircraft cabin pressure conditions.

Journal of travel medicine 20050101

Acute hepatitis and atovaquone/proguanil.

Journal of travel medicine 20050101

2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation.

Archives of biochemistry and biophysics 20041215

Malaria: prevention in travellers.

Clinical evidence 20041201

Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe.

The Journal of infectious diseases 20041101

[New aspects of epidemiology and treatment of Pneumocystis carinii infection].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20041101

Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro.

Veterinary parasitology 20040920

Quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy.

Internal medicine (Tokyo, Japan) 20040701

[Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].

MMW Fortschritte der Medizin 20040617

Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040615

Combined effect of atovaquone and pyrrolidine dithiocarbamate in the treatment of acute murine toxoplasmosis.

Chemotherapy 20040601

Pneumocystis carinii pneumonia treatment in people infected with HIV.

Clinical evidence 20040601

Malaria: prevention in travellers.

Clinical evidence 20040601

Failure of low-dose atovaquone prophylaxis against Pneumocystis jiroveci infection in transplant recipients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040415

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

Protein science : a publication of the Protein Society 20040401

NADH-ubiquinone oxidoreductase activity in the kinetoplasts of the plant trypanosomatid Phytomonas serpens.

Parasitology research 20040301

Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.

Tropical medicine & international health : TM & IH 20040301

A malaria outbreak following a British military deployment to Sierra Leone.

The Journal of infection 20040201

CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.

Tropical medicine & international health : TM & IH 20040201

Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae.

The Journal of biological chemistry 20040123

Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.

Malaria journal 20040101

Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs.

Journal of veterinary internal medicine 20040101

Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark.

Journal of travel medicine 20040101

Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031201

Military aviators, special operations forces, and causal malaria prophylaxis.

Military medicine 20031201

HIV: prevention of opportunistic infections.

Clinical evidence 20031201

Malaria: prevention in travellers.

Clinical evidence 20031201

Diagnosis and treatment of malaria in children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115

New antimalarial drugs.

Angewandte Chemie (International ed. in English) 20031110

The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.

European journal of clinical pharmacology 20031001

Atovaquone-proguanil for prophylaxis and treatment of malaria.

The Annals of pharmacotherapy 20030901

Atovaquone-proguanil for recrudescent Plasmodium falciparum in Vietnam.

Annals of tropical medicine and parasitology 20030901

Malaria and children: the risks, precautions, and the nurse's role.

Professional nurse (London, England) 20030901

Molecular basis for atovaquone binding to the cytochrome bc1 complex.

The Journal of biological chemistry 20030815

Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030801

Reinstituting trimethoprim--sulfamethoxazole in patients receiving atovaquone for Pneumocystis carinii pneumonia prophylaxis.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030801

Molecular epidemiology of malaria in Cameroon. XVII. Baseline monitoring of atovaquone-resistant Plasmodium falciparum by in vitro drug assays and cytochrome b gene sequence analysis.

The American journal of tropical medicine and hygiene 20030801

Stevens-Johnson syndrome associated with Malarone antimalarial prophylaxis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030701

The impact of Malarone and primaquine on psychomotor performance.

Aviation, space, and environmental medicine 20030701

HIV: opportunistic infections.

Clinical evidence 20030601

Atovaquone/proguanil: the need for family protection.

Journal of travel medicine 20030501

The safety of atovaquone/proguanil in long-term malaria prophylaxis of nonimmune adults.

Journal of travel medicine 20030501

Post-marketing surveillance: adverse events during long-term use of atovaquone/proguanil for travelers to malaria-endemic countries.

Journal of travel medicine 20030501

Toxicity related to chloroquine treatment of resistant vivax malaria.

The Annals of pharmacotherapy 20030401

The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria.

Fundamental & clinical pharmacology 20030401

Problems in prescribing malaria chemoprophylaxis for travelers.

Fundamental & clinical pharmacology 20030401

Therapeutic evaluation of free and nanocapsule-encapsulated atovaquone in the treatment of murine visceral leishmaniasis.

Annals of tropical medicine and parasitology 20030401

Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports.

BMJ (Clinical research ed.) 20030322

[Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atovaquone-proguanil, artemether-lumefantrine and artemotil].

Nederlands tijdschrift voor geneeskunde 20030215

Atovaquone-loaded nanocapsules: influence of the nature of the polymer on their in vitro characteristics.

International journal of pharmaceutics 20030102

Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro.

The American journal of tropical medicine and hygiene 20030101

Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria.

Drugs 20030101

Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker.

Malaria journal 20030101

The efficacy of chemoprophylaxis against malaria with chloroquine plus proguanil, mefloquine, and atovaquone plus proguanil in travelers from Denmark.

Journal of travel medicine 20030101

Current status and replies to frequently posed questions on atovaquone plus proguanil (Malarone) for the prevention of malaria.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101

Detection of atovaquone and Malarone resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb).

Molecular and cellular probes 20030101

Plasmodium falciparum outwits Malarone, protector of travellers.

Bulletin of the World Health Organization 20030101

Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.

Journal of travel medicine 20030101

Atovaquone/proguanil resistance in Africa: a case report.

Scandinavian journal of infectious diseases 20030101

Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215

Efficacy of atovaquone combined with clindamycin against murine infection with a cystogenic (Me49) strain of Toxoplasma gondii.

The Journal of antimicrobial chemotherapy 20021201

Efficacy of atovaquone/proguanil for malaria prophylaxis in children and its effect on the immunogenicity of live oral typhoid and cholera vaccines.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021115

Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021101

Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021001

[Preventive vaccination for travel. Every dog has it, but only every 10th grandmother].

MMW Fortschritte der Medizin 20020919

[Blackwater fever].

Presse medicale (Paris, France : 1983) 20020907

Atovaquone plus chloroguanide versus mefloquine for malaria prophylaxis: a focus on neuropsychiatric adverse events.

Clinical pharmacology and therapeutics 20020901

[Value of malarone in therapy of malaria tropica].

Medizinische Klinik (Munich, Germany : 1983) 20020815

Babesiosis in humans: a treatment review.

Expert opinion on pharmacotherapy 20020801

Atovaquone/proguanil for plasmodium falciparum malaria.

The Pediatric infectious disease journal 20020801

[New strategies in therapy to roll back malaria].

Deutsche medizinische Wochenschrift (1946) 20020726

Characterisation of atovaquone resistance in Leishmania infantum promastigotes.

International journal for parasitology 20020701

Determination of atovaquone in tablets by differential pulse polarography.

Die Pharmazie 20020701

Zoonotic babesiosis.

International journal of medical microbiology : IJMM 20020601

Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche sur le SIDA, Essai 039.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501

Tolerability of antimalaria drugs.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501

Genetic analysis of tachyzoite to bradyzoite differentiation mutants in Toxoplasma gondii reveals a hierarchy of gene induction.

Molecular microbiology 20020501

Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines.

Archives of internal medicine 20020422

Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis.

European journal of clinical pharmacology 20020401

Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation.

European journal of clinical pharmacology 20020401

[Malarone: a new antimalarial for malaria chemoprevention].