M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues.

Journal of hepatology 20120801

Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates.

Molecular and biochemical parasitology 20120801

Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials.

European journal of medicinal chemistry 20120801

Chlorhexidine inhibits the activity of dental cysteine cathepsins.

Journal of dental research 20120401

First-time report of metalloproteinases in fish bile and their potential as bioindicators regarding environmental contamination.

Aquatic toxicology (Amsterdam, Netherlands) 20120401

Prolonged signalling and trafficking of the bradykinin B2 receptor stimulated with the amphibian peptide maximakinin: insight into the endosomal inactivation of kinins.

Pharmacological research 20120201

Design and synthesis of small molecular dual inhibitor of falcipain-2 and dihydrofolate reductase as antimalarial agent.

Bioorganic & medicinal chemistry letters 20120115

Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.

The American journal of pathology 20120101

Cysteine peptidases, secreted by Trichomonas gallinae, are involved in the cytopathogenic effects on a permanent chicken liver cell culture.

PloS one 20120101

Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents.

Bioorganic & medicinal chemistry 20111215

Cysteine proteases in differentiation of embryonic stem cells into neural cells.

Stem cells and development 20111101

Partial purification and characterisation of cysteine protease in wheat germ.

Journal of the science of food and agriculture 20111001

Identification and characterization of cysteine proteinases of Trypanosoma evansi.

Parasitology research 20110901

C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism.

The FEBS journal 20110901

Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases.

Insect biochemistry and molecular biology 20110601

Design and synthesis of protein-protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors.

European journal of medicinal chemistry 20110601

Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies.

Journal of medicinal chemistry 20110526

Fluoride does not inhibit enamel protease activity.

Journal of dental research 20110401

Cysteine cathepsins in human carious dentin.

Journal of dental research 20110401

Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents.

Bioorganic & medicinal chemistry letters 20110401

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.

European journal of medicinal chemistry 20110301

Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.

Oncogene 20110217

Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.

Bioorganic & medicinal chemistry 20110201

Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.

Experimental parasitology 20110101

Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils.

International archives of allergy and immunology 20110101

Microarray analysis reveals strategies of Tribolium castaneum larvae to compensate for cysteine and serine protease inhibitors.

Comparative biochemistry and physiology. Part D, Genomics & proteomics 20101201

Intracellular cathepsin B activity is inversely correlated with the quality and developmental competence of bovine preimplantation embryos.

Molecular reproduction and development 20101201

Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.

Clinical and experimental immunology 20101101

Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.

The FEBS journal 20101101

The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles.

FEBS letters 20101022

Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticola.

Biological chemistry 20100901

Collagenolytic activity in sonic extracts of Tannerella forsythia.

Archives of oral biology 20100801

A novel Ca2+-activated protease from germinating Vigna radiata seeds and its role in storage protein mobilization.

Journal of plant physiology 20100715

Constrained peptidomimetics as antiplasmodial falcipain-2 inhibitors.

Bioorganic & medicinal chemistry 20100715

Synthesis of novel peptidomimetics as inhibitors of protozoan cysteine proteases falcipain-2 and rhodesain.

European journal of medicinal chemistry 20100701

Hydrogen peroxide-induced apoptosis-like cell death in Entamoeba histolytica.

Parasitology international 20100601

Treatment development for systemic Tetrahymena sp. infection in guppies, Poecilia reticulata Peters.

Journal of fish diseases 20100601

Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence.

Molecular reproduction and development 20100501

Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.

Journal of neurochemistry 20100501

Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.

International journal of oncology 20100401

Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids.

Journal of medicinal chemistry 20100311

Synthesis, antimalarial and antitubercular activity of acetylenic chalcones.

Bioorganic & medicinal chemistry letters 20100201

Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.

Journal of the science of food and agriculture 20100201

Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality.

BMC musculoskeletal disorders 20100101

Stimulation of fibroblast proliferation by the plant cysteine protease CMS2MS2 is independent of its proteolytic activity and requires ERK activation.

Biological chemistry 20091201

Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis.

Parasitology research 20091201

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.

Journal of medicinal chemistry 20090924

Novel 2H-isoquinolin-3-ones as antiplasmodial falcipain-2 inhibitors.

Bioorganic & medicinal chemistry 20090915

Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model.

Journal of neurochemistry 20090901

Dissimilar peptidase production by avirulent and virulent promastigotes of Leishmania braziliensis: inference on the parasite proliferation and interaction with macrophages.

Parasitology 20090901

Identification of novel falcipain-2 inhibitors as potential antimalarial agents through structure-based virtual screening.

Journal of medicinal chemistry 20090813

House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity.

FEBS letters 20090618

Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition.

Bioorganic & medicinal chemistry letters 20090615

Novel peptidomimetics containing a vinyl ester moiety as highly potent and selective falcipain-2 inhibitors.

Journal of medicinal chemistry 20090409

The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.

The Korean journal of laboratory medicine 20090401

Antiparasitic activity of cystine protease inhibitor E-64 against Giardia lamblia excystation in vitro and in vivo.

Journal of the Egyptian Society of Parasitology 20090401

Natural polyprenylated benzophenones inhibiting cysteine and serine proteases.

European journal of medicinal chemistry 20090301

Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.

International immunopharmacology 20090301

Cathepsin K regulates adipocyte differentiation: possible involvement of type I collagen degradation.

Endocrine journal 20090101

Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.

Experimental parasitology 20081201

Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant.

Bioorganic & medicinal chemistry 20081101

Beta-lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana.

Nature chemical biology 20080901

A prodomain peptide of Plasmodium falciparum cysteine protease (falcipain-2) inhibits malaria parasite development.

Journal of medicinal chemistry 20080612

Activity-based selection of a proteolytic species using ribosome display.

Biochemical and biophysical research communications 20080523

Plasmodium food vacuole plasmepsins are activated by falcipains.

The Journal of biological chemistry 20080509

Studies on synchronous egress of coccidian parasites (Neospora caninum, Toxoplasma gondii, Eimeria bovis) from bovine endothelial host cells mediated by calcium ionophore A23187.

Veterinary research communications 20080401

Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.

Allergology international : official journal of the Japanese Society of Allergology 20080301

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

Journal of medicinal chemistry 20080227

Molecular determination of laminin-5 degradation: a biomarker for mustard gas exposure diagnosis and its mechanism of action.

Experimental dermatology 20080101

[Flu virion as a substrate for proteolytic enzymes].

Bioorganicheskaia khimiia 20080101

Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum.

The Journal of biological chemistry 20071207

Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).

Molecular and biochemical parasitology 20071201

In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.

Journal of medicinal chemistry 20071129

Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes.

Parasitology 20071101

Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.

Experimental parasitology 20071001

In vitro activity of the nonsteroidal anti-inflammatory drug indomethacin on a scuticociliate parasite of farmed turbot.

Veterinary parasitology 20070930

Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus.

Developmental biology 20070801

Development of tier-I toxicity assays for Orius insidiosus (Heteroptera: Anthocoridae) for assessing the risk of plant-incorporated protectants to nontarget heteropterans.

Environmental entomology 20070801

Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing.

The Journal of biological chemistry 20070720

Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor.

Zoological science 20070501

Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.

Cell death and differentiation 20070301

Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Antimicrobial agents and chemotherapy 20070201

Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion.

Antimicrobial agents and chemotherapy 20070201

[Hepatic amebiasis].

Revista de gastroenterologia de Mexico 20061101

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.

The Journal of clinical investigation 20061002

Characterization of HC58cDNA, a putative cysteine protease from the parasite Haemonchus contortus.

Journal of veterinary science 20060901

Aspartic proteinases in the digestive tract of marine decapod crustaceans.

Journal of experimental zoology. Part A, Comparative experimental biology 20060801

Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses.

Journal of immunology (Baltimore, Md. : 1950) 20060801

Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae.

Cellular microbiology 20060601

Microinjection of an antibody against the cysteine-protease involved in male chromatin remodeling blocks the development of sea urchin embryos at the initial cell cycle.

Journal of cellular biochemistry 20060515

Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis.

Parasitology research 20060401

Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory.

Journal of medicinal chemistry 20060309

Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.

International journal for parasitology 20060101

Protein aggregates are transported to vacuoles by a macroautophagic mechanism in nutrient-starved plant cells.

Autophagy 20060101

High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.

Analytical chemistry 20051215

Characterization of cathepsin L secreted by Sf21 insect cells.

Archives of biochemistry and biophysics 20051201

Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes.

The Korean journal of parasitology 20051201

Pathogenicity of Vibrio penaeicida for white shrimp Litopenaeus vannamei: a cysteine protease-like exotoxin as a virulence factor.

Diseases of aquatic organisms 20051128

Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.

FEBS letters 20050815

[Effects of MG132 , an inhibitor of proteasome , on the pollen germination and tube growth of Pecea wilsonii].

Shi yan sheng wu xue bao 20050801

The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.

Proceedings of the National Academy of Sciences of the United States of America 20050726

Fasciola hepatica proteolytic activity in liver revealed by in situ zymography.

Parasitology research 20050701

Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance.

Science (New York, N.Y.) 20050617

Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.

Journal of medicinal chemistry 20050519

Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.

Experimental cell research 20050515

Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury.

Biochemical pharmacology 20050401

Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides.

Bioorganic & medicinal chemistry 20050301

Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.

Parasitology 20050201

The role of Plasmodium falciparum food vacuole plasmepsins.

The Journal of biological chemistry 20050114

Candida guilliermondii isolated from HIV-infected human secretes a 50 kDa serine proteinase that cleaves a broad spectrum of proteinaceous substrates.

FEMS immunology and medical microbiology 20050101

Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis.

FEBS letters 20041217

Identification of novel parasitic cysteine protease inhibitors using virtual screening. 1. The ChemBridge database.

Journal of medicinal chemistry 20041216

Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma.

Haematologica 20041201

Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.

The Journal of veterinary medical science 20041001

Role of cysteine proteinase of Entamoeba histolytica in target cell death.

Parasitology 20040801

Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.

The Biochemical journal 20040715

The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.

Acta tropica 20040701

Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters.

Parasitology 20040701

Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.

The Journal of biological chemistry 20040625

Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells.

International immunology 20040501

Colorado potato beetles show differential digestive compensatory responses to host plants expressing distinct sets of defense proteins.

Archives of insect biochemistry and physiology 20040301

A cysteine protease from Taenia solium metacestodes induce apoptosis in human CD4+ T-cells.

Parasitology research 20040201

In vitro activation of the hemolysin in Prevotella nigrescens ATCC 33563 and Prevotella intermedia ATCC 25611.

Research in microbiology 20040101

Monocytes stimulated with group B streptococci or interferons release tumour necrosis factor-related apoptosis-inducing ligand.

Scandinavian journal of immunology 20040101

A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.

Connective tissue research 20040101

Effects of supplemental L-methionine on E-64 [trans-epoxysuccinyl-1-leucyl-amido (4-guanido) butane]-induced dysmorphology in rat embryos cultured in vitro.

Congenital anomalies 20031201

Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases.

International journal of cancer 20030901

Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF.

International archives of allergy and immunology 20030901

Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.

Cell death and differentiation 20030801

Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).

Archives of insect biochemistry and physiology 20030301

Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.

Journal of helminthology 20030301

Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cysteine proteinase, cathepsin K, in osteoclasts.

The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20030201

Selective modulation of superantigen-induced responses by streptococcal cysteine protease.

The Journal of infectious diseases 20030201

Thiol-activated serine proteinases from nymphal hemolymph of the African migratory locust, Locusta migratoria migratorioides.

Archives of biochemistry and biophysics 20030201

Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis.

American journal of respiratory cell and molecular biology 20030101

The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20030101

Calpain inhibitors, a treatment for Alzheimer's disease: position paper.

Journal of molecular neuroscience : MN 20030101

Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.

American journal of physiology. Lung cellular and molecular physiology 20021001

Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.

Planta 20020901

pH Dependence of inhibitors targeting the occluding loop of cathepsin B.

Bioorganic chemistry 20020801

A noninvasive cell-based assay for monitoring proteolytic activity within a specific subcellular compartment.

Analytical biochemistry 20020715

Stage-specific antimalarial activity of cysteine protease inhibitors.

Biological chemistry 20020501

A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosis.

Science (New York, N.Y.) 20020426

Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.

International journal of cancer 20020220

A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes.

Journal of bone and mineral metabolism 20020101

Differential activity of cathepsin L in human placenta at two different stages of gestation.

Placenta 20020101

E 64.

Drugs in R&D 20020101

Elevated levels of cathepsin B in human glioblastoma cell lines.

International journal of oncology 20010901

Biochemical alteration of membrane-associated IL-6 RI (80-kDa) in adherent macrophages and vascular endothelium.

Molecular immunology 20010901

Defining a link between gap junction communication, proteolysis, and cataract formation.

The Journal of biological chemistry 20010803

Therapeutic effects of cysteine protease inhibition in allergic lung inflammation: inhibition of allergen-specific T lymphocyte migration.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010801

The role of calpain in caspase activation during etoposide induced apoptosis in T cells.

European journal of immunology 20010701

Enhancement of protease activity involved in modulation of cell mutability by microgravity stress in UVC-irradiated human cells.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 20010701

Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.

Journal of immunology (Baltimore, Md. : 1950) 20010501

Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.

Cancer research 20010501

Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010501

Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.

Biological chemistry 20010501

Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.

The Journal of biological chemistry 20010427

Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.

BioTechniques 20010401

3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.

Archives of biochemistry and biophysics 20010215

Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR.

Calcified tissue international 20010201

Protease inhibitors: current status and future prospects.

Journal of medicinal chemistry 20000210