(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide
| Title | Journal |
|---|---|
| Involvement of stimulation of α7 nicotinic acetylcholine receptors in the suppressive effect of tropisetron on dextran sulfate sodium-induced colitis in mice. | Journal of pharmacological sciences 20150301 |
| Effects of nicotinic acetylcholine receptor agonists on cognition in rhesus monkeys with a chronic cocaine self-administration history. | Neuropharmacology 20130101 |
| Activation of the alpha-7 nicotinic acetylcholine receptor (α7 nAchR) reverses referred mechanical hyperalgesia induced by colonic inflammation in mice. | Neuropharmacology 20121001 |
| Stroke-induced activation of the α7 nicotinic receptor increases Pseudomonas aeruginosa lung injury. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120701 |
| Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain. | Journal of pharmacological and toxicological methods 20120701 |
| Synthesis and nicotinic receptor activity of chemical space analogues of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711). | Journal of medicinal chemistry 20120524 |
| α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage. | Stroke 20120301 |
| Combined α7 nicotinic acetylcholine receptor agonism and partial serotonin transporter inhibition produce antidepressant-like effects in the mouse forced swim and tail suspension tests: a comparison of SSR180711 and PNU-282987. | Pharmacology, biochemistry, and behavior 20120101 |
| α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats. | Stroke 20111201 |
| Subtype-selective nicotinic acetylcholine receptor agonists enhance the responsiveness to citalopram and reboxetine in the mouse forced swim test. | Journal of psychopharmacology (Oxford, England) 20111001 |
| Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs). | Toxicology letters 20110925 |
| Chemical and genetic engineering of selective ion channel-ligand interactions. | Science (New York, N.Y.) 20110902 |
| Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation. | Toxicological sciences : an official journal of the Society of Toxicology 20110901 |
| Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: implications for therapy of cognitive dysfunction in schizophrenia. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20110401 |
| Human platelets express functional alpha7-nicotinic acetylcholine receptors. | Arteriosclerosis, thrombosis, and vascular biology 20110401 |
| Role of mouse cerebellar nicotinic acetylcholine receptor (nAChR) α(4)β(2)- and α(7) subtypes in the behavioral cross-tolerance between nicotine and ethanol-induced ataxia. | Behavioural brain research 20110301 |
| The role of nicotinic acetylcholine receptor (nAChR) α7 subtype in the functional interaction between nicotine and ethanol in mouse cerebellum. | Alcoholism, clinical and experimental research 20110301 |
| Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor. | The Journal of pharmacology and experimental therapeutics 20110201 |
| Dysfunction of the cholinergic anti-inflammatory pathway mediates organ damage in hypertension. | Hypertension (Dallas, Tex. : 1979) 20110201 |
| Activation of α7 nicotinic acetylcholine receptors ameliorates indomethacin-induced small intestinal ulceration in mice. | European journal of pharmacology 20110110 |
| Behavioral effects of PNU-282987, an alpha7 nicotinic receptor agonist, in mice. | Behavioural brain research 20110101 |
| Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release. | British journal of pharmacology 20110101 |
| Activation of nicotinic cholinergic receptors prevents ventilator-induced lung injury in rats. | PloS one 20110101 |
| [Nicotine effects on mitochondria membrane potential: participation of nicotinic acetylcholine receptors]. | Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20110101 |
| Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway. | Free radical biology & medicine 20101201 |
| Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands. | Journal of medicinal chemistry 20101014 |
| Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells. | Neurochemistry international 20101001 |
| Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. | Pain 20100901 |
| Overexpressed alpha7 nicotinic acetylcholine receptor inhibited proinflammatory cytokine release in NIH3T3 cells. | Journal of bioscience and bioengineering 20090801 |
| Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. | Journal of medicinal chemistry 20090528 |
| Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice. | European journal of pharmacology 20090105 |
| Acetylcholine regulation of synoviocyte cytokine expression by the alpha7 nicotinic receptor. | Arthritis and rheumatism 20081101 |
| Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity. | Bioorganic & medicinal chemistry letters 20080615 |
| The hepatic vagus nerve attenuates Fas-induced apoptosis in the mouse liver via alpha7 nicotinic acetylcholine receptor. | Gastroenterology 20080601 |
| Memantine protects against amphetamine derivatives-induced neurotoxic damage in rodents. | Neuropharmacology 20080601 |
| Analysis of gene expression profiles in rat hippocampus following treatment with nicotine and an alpha7 nAChR selective agonist. | Neuroscience research 20080301 |
| [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. | The Journal of pharmacology and experimental therapeutics 20080101 |
| Memantine prevents MDMA-induced neurotoxicity. | Neurotoxicology 20080101 |
| Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. | Molecular pharmacology 20070901 |
| Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats. | American journal of respiratory cell and molecular biology 20070801 |
| High content screen microscopy analysis of A beta 1-42-induced neurite outgrowth reduction in rat primary cortical neurons: neuroprotective effects of alpha 7 neuronal nicotinic acetylcholine receptor ligands. | Brain research 20070602 |
| Alpha-7 nicotinic acetylcholine receptor agonists selectively activate limbic regions of the rat forebrain: an effect similar to antipsychotics. | Journal of neuroscience research 20070601 |
| Frontal cortical alpha7 and alpha4beta2 nicotinic acetylcholine receptors in working and reference memory. | Neuropharmacology 20070601 |
| Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship. | Journal of medicinal chemistry 20060713 |
| Activation of alpha7 acetylcholine receptors augments stimulation-induced hippocampal theta oscillation. | The European journal of neuroscience 20060101 |
| The selective alpha7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic activity in brain slices and restores auditory gating deficits in anesthetized rats. | The Journal of pharmacology and experimental therapeutics 20050301 |
| Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. | Journal of medicinal chemistry 20050224 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |