Home Other Building Blocks N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

CAS No.:
77377-52-7
Catalog Number:
AG0036J3
Molecular Formula:
C9H18F3NOSi
Molecular Weight:
241.3260
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
>95.0%(GC)
1 week
United States
$69
- +
10g
>95.0%(GC)
1 week
United States
$219
- +
Product Description
Catalog Number:
AG0036J3
Chemical Name:
N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide
CAS Number:
77377-52-7
Molecular Formula:
C9H18F3NOSi
Molecular Weight:
241.3260
MDL Number:
MFCD00009671
IUPAC Name:
N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
InChI:
InChI=1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
InChI Key:
QRKUHYFDBWGLHJ-UHFFFAOYSA-N
SMILES:
O=C(C(F)(F)F)N([Si](C(C)(C)C)(C)C)C
Properties
Complexity:
255  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
241.111g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
241.329g/mol
Monoisotopic Mass:
241.111g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
20.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in sediment samples by combining subcritical water extraction and dispersive liquid-liquid microextraction with derivatization. Analytica chimica acta 20121113
Determination of Δ9-tetrahydrocannabinol and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in water samples by solid-phase microextraction with on-fiber derivatization and gas chromatography-mass spectrometry. Journal of chromatography. A 20120706
Gas chromatography-mass spectrometry method for the determination of free amino acids as their dimethyl-tert-butylsilyl (TBDMS) derivatives in animal source food. Journal of agricultural and food chemistry 20120314
Resolving phenylalanine metabolism sheds light on natural synthesis of penicillin G in Penicillium chrysogenum. Eukaryotic cell 20120201
Analysis of endocrine disrupting compounds, pharmaceuticals and personal care products in sewage sludge by gas chromatography-mass spectrometry. Talanta 20120130
Measurement of hepatic protein fractional synthetic rate with stable isotope labeling technique in thapsigargin stressed HepG2 cells. International journal of biological sciences 20120101
Metabolic pathway confirmation and discovery through (13)C-labeling of proteinogenic amino acids. Journal of visualized experiments : JoVE 20120101
Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111215
Simultaneous analysis of pesticides from different chemical classes by using a derivatisation step and gas chromatography-mass spectrometry. Journal of chromatography. A 20111104
Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide. Archives of toxicology 20110601
Simultaneous determination of 2-naphthol and 1-hydroxy pyrene in urine by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110301
Analytical method for assessing potential dermal exposure to pesticides of a non-agricultural occupationally exposed population. Analytical and bioanalytical chemistry 20110101
A fully validated method for the determination of vardenafil in blood using gas chromatography/mass spectrometry. Journal of mass spectrometry : JMS 20110101
Stable isotopic profiling of intermediary metabolic flux in developing and adult stage Caenorhabditis elegans. Journal of visualized experiments : JoVE 20110101
Rapeseed and milk protein exhibit a similar overall nutritional value but marked difference in postprandial regional nitrogen utilization in rats. Nutrition & metabolism 20110101
Catabolic regulation analysis of Escherichia coli and its crp, mlc, mgsA, pgi and ptsG mutants. Microbial cell factories 20110101
Metabolic engineering of the L-phenylalanine pathway in Escherichia coli for the production of S- or R-mandelic acid. Microbial cell factories 20110101
An empirical Bayes model using a competition score for metabolite identification in gas chromatography mass spectrometry. BMC bioinformatics 20110101
Determination of synthetic phenolic antioxidants and their metabolites in water samples by downscaled solid-phase extraction, silylation and gas chromatography-mass spectrometry. Journal of chromatography. A 20101008
Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria. Journal of inherited metabolic disease 20101001
Determination of triclosan and methyl triclosan in environmental solid samples by matrix solid-phase dispersion and gas chromatography-mass spectrometry. Journal of separation science 20100901
Artifacts related to N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide derivatization of citrulline revealed by gas chromatography-mass spectrometry using both electron and chemical ionization. Journal of chromatography. A 20100813
Trimethylsilyldiazomethane (TMSD) as a new derivatization reagent for trace analysis of selected non-steroidal anti-inflammatory drugs (NSAIDs) by gas chromatography methods. Analytical and bioanalytical chemistry 20100801
In-sample acetylation-non-porous membrane-assisted liquid-liquid extraction for the determination of parabens and triclosan in water samples. Analytical and bioanalytical chemistry 20100701
Determination of butoxyacetic acid (biomarker of ethylene glycol monobutyl ether exposure) in human urine candidate reference material. Analytical and bioanalytical chemistry 20100501
11-nor-Delta9-tetrahydrocannabinol-9-carboxylic acid ethyl ester (THC-COOEt): unsuccessful search for a marker of combined cannabis and alcohol consumption. Forensic science international 20100320
Optimization of N-methyl-N-[tert-butyldimethylsilyl]trifluoroacetamide as a derivatization agent for determining isotopic enrichment of glycerol in very-low density lipoproteins. Rapid communications in mass spectrometry : RCM 20100315
Trace analysis of free and combined amino acids in atmospheric aerosols by gas chromatography-mass spectrometry. Journal of chromatography. A 20100101
Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS). Methods in molecular biology (Clifton, N.J.) 20100101
Multivariate modeling identifies neutrophil- and Th17-related factors as differential serum biomarkers of chronic murine colitis. PloS one 20100101
Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylation. Rapid communications in mass spectrometry : RCM 20090901
One-step extraction and derivatization liquid-phase microextraction for the determination of chlorophenols by gas chromatography-mass spectrometry. Journal of chromatography. A 20090828
Evaluation of principal cannabinoids in airborne particulates. Analytica chimica acta 20090508
Comparison of MTBSTFA and BSTFA in derivatization reactions of polar compounds prior to GC/MS analysis. Talanta 20090215
The detection of various opiates and benzodiazepines by comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20090201
Dispersive liquid-liquid microextraction applied to the simultaneous derivatization and concentration of triclosan and methyltriclosan in water samples. Journal of chromatography. A 20090109
Determination of creatine and guanidinoacetate by GC-MS: study of their stability in urine at different temperatures. Clinical biochemistry 20090101
Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response. PloS one 20090101
The effect of high glucocorticoid administration and food restriction on rodent skeletal muscle mitochondrial function and protein metabolism. PloS one 20090101
[Determination of chlorpyrifos and its metabolite in vegetables using gas chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography 20090101
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PloS one 20090101
Solid phase microextraction procedure for the determination of alkylphenols in water by on-fiber derivatization with N-tert-butyl-dimethylsilyl-N-methyltrifluoroacetamide. Analytica chimica acta 20080829
Simultaneous determination of pharmaceuticals, endocrine disrupting compounds and hormone in soils by gas chromatography-mass spectrometry. Journal of chromatography. A 20080822
Identification and quantification of ibuprofen, naproxen, ketoprofen and diclofenac present in waste-waters, as their trimethylsilyl derivatives, by gas chromatography mass spectrometry. Talanta 20080730
Simplified sample preparation method for triclosan and methyltriclosan determination in biota and foodstuff samples. Journal of chromatography. A 20080425
Differential metabolomics using stable isotope labeling and two-dimensional gas chromatography with time-of-flight mass spectrometry. Analytical chemistry 20080101
Simultaneous analysis of lysine, Nepsilon-carboxymethyllysine and lysinoalanine from proteins. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201
Optimisation of the on-fibre derivatisation of volatile fatty acids in the simultaneous determination together with phenols and indoles in cow slurries. Analytical and bioanalytical chemistry 20071101
Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection. Analytical and bioanalytical chemistry 20070601
Changes in the sugarcane metabolome with stem development. Are they related to sucrose accumulation? Plant & cell physiology 20070401
Determination of parabens and triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry. Analytical chemistry 20070215
Fluxome analysis using GC-MS. Microbial cell factories 20070101
Highly selective sample preparation and gas chromatographic-mass spectrometric analysis of chlorpyrifos, diazinon and their major metabolites in sludge and sludge-fertilized agricultural soils. Journal of chromatography. A 20061103
Determination of nitrogen mustard hydrolysis products, ethanolamines by gas chromatography-mass spectrometry after tert-butyldimethylsilyl derivatization. Journal of chromatography. A 20060728
Fast gas chromatography-negative-ion chemical ionization mass spectrometry with microscale volume sample preparation for the determination of benzodiazepines and alpha-hydroxy metabolites, zaleplon and zopiclone in whole blood. Journal of mass spectrometry : JMS 20060601
Determination of ethephon residues in water by gas chromatography with cubic mass spectrometry after ion-exchange purification and derivatisation with N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide. Journal of chromatography. A 20060303
Optimization of silylation using N-methyl-N-(trimethylsilyl)-trifluoroacetamide, N,O-bis-(trimethylsilyl)-trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry. Journal of chromatography. A 20060303
Analysis of tert-butyldimethylsilyl derivatives in heavy gas oil from Brazilian naphthenic acids by gas chromatography coupled to mass spectrometry with electron impact ionization. Journal of chromatography. A 20060210
Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202
A validated positive chemical ionization GC/MS method for the identification and quantification of amphetamine, opiates, cocaine, and metabolites in human postmortem brain. Journal of mass spectrometry : JMS 20060201
Comparison and evaluation of analysis procedures for the quantification of (2-methoxyethoxy)acetic acid in urine. Analytical and bioanalytical chemistry 20050901
Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705
Validated toxicological determination of 30 drugs of abuse as optimized derivatives in oral fluid by long column fast gas chromatography/electron impact mass spectrometry. Journal of mass spectrometry : JMS 20050601
Determination of 14 benzodiazepines and hydroxy metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425
Optimization of solid-phase microextraction conditions for the determination of triclosan and possible related compounds in water samples. Journal of chromatography. A 20050422
Application of gas chromatography-mass spectrometry for the determination of urinary ethylenethiourea in humans. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050125
Determination and quantification of alpha,beta,gamma,delta-unsaturated aldehydes as pentafluorobenzyl-oxime derivates in diatom cultures and natural phytoplankton populations: application in marine field studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050105
Determination of thiodiglycol, a mustard gas hydrolysis product by gas chromatography-mass spectrometry after tert-butyldimethylsilylation. Journal of chromatography. A 20041224
A multiresidue method for the analysis of phenols and nitrophenols in the atmosphere. Journal of environmental monitoring : JEM 20041201
Analysis of heterocyclic aromatic amines in foods by gas chromatography-mass spectrometry as their tert.-butyldimethylsilyl derivatives. Journal of chromatography. A 20040618
Determination of picogram levels of midazolam, and 1- and 4-hydroxymidazolam in human plasma by gas chromatography-negative chemical ionization-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405
Development of a gas chromatographic test for the quantification of the biomarker 3-bromopropionic acid in human urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040405
Suitability of N,O-bis(trimethylsilyl)trifluoroacetamide and N-(tert-butyldimethylsilyl)-N-methyltrifluoroacetamide as derivatization reagents for the determination of the estrogens estrone and 17alpha-ethinylestradiol by gas chromatography-mass spectrometry. Journal of chromatography. A 20040213
Solid-phase microextraction with on-fiber derivatization for the analysis of anti-inflammatory drugs in water samples. Journal of chromatography. A 20040123
Quantification of bacterial lipopolysaccharides (endotoxin) by GC-MS determination of 3-hydroxy fatty acids. Journal of environmental monitoring : JEM 20040101
Analysis of O,S-dimethyl hydrogen phosphorothioate in urine, a specific biomarker for methamidophos. Journal of agricultural and food chemistry 20031008
13C enrichment of extracellular neurotransmitter glutamate in rat brain--combined mass spectrometry and NMR studies of neurotransmitter turnover and uptake into glia in vivo. Cellular and molecular biology (Noisy-le-Grand, France) 20030701
Determination of the herbicide glyphosate and its metabolite in biological specimens by gas chromatography-mass spectrometry. A case of poisoning by roundup herbicide. Journal of analytical toxicology 20030401
Application of spectroscopic and computational methods in the study of the electronic excitations of partially silylated hydroxyquinones. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030315
Simultaneous determination of methionine sulfoxide and methionine in blood plasma using gas chromatography-mass spectrometry. Analytical biochemistry 20030201
Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives. Journal of chromatography. A 20030124
Stable isotope dilution method for the determination of guanidinoacetic acid by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM 20030101
Gas chromatography-mass spectrometry method for determination of phenylalanine and tyrosine in neonatal blood spots. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021125
In vivo microdialysis and gas-chromatography/mass-spectrometry for 13C-enrichment measurement of extracellular glutamate in rat brain. Journal of neuroscience methods 20021030
New gas chromatographic-mass spectrometric method for the determination of urinary pyrethroid metabolites in environmental medicine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005
Analysis of glycated and ascorbylated proteins by gas chromatography-mass spectrometry. Journal of agricultural and food chemistry 20020925
Assay of serum allantoin in humans by gas chromatography-mass spectrometry. Clinica chimica acta; international journal of clinical chemistry 20020401
Separation, identification, and quantification of amino acids in L-lysine fermentation potato juices by gas chromatography-mass spectrometry. Fresenius' journal of analytical chemistry 20011001
Analysis of 3,5,6-trichloro-2-pyridinol in urine samples from the general population using gas chromatography-mass spectrometry after steam distillation and solid-phase extraction. Journal of chromatography. B, Biomedical sciences and applications 20010805
Determination of thiodyglycol in groundwater using solid-phase extraction followed by gas chromatography with mass spectrometric detection in the selected-ion mode. Journal of chromatography. A 20010309
Properties