Home Halogens (11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione

CAS No.:
83919-23-7
Catalog Number:
AG0036F7
Molecular Formula:
C27H30Cl2O6
Molecular Weight:
521.4295
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
98%(HPLC)
In Stock USA
United States
$54
- +
50mg
98%(HPLC)
In Stock USA
United States
$86
- +
100mg
98%(HPLC)
In Stock USA
United States
$144
- +
250mg
98%(HPLC)
In Stock USA
United States
$297
- +
Product Description
Catalog Number:
AG0036F7
Chemical Name:
(11β,16α)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS Number:
83919-23-7
Molecular Formula:
C27H30Cl2O6
Molecular Weight:
521.4295
MDL Number:
MFCD00866003
IUPAC Name:
[(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] furan-2-carboxylate
InChI:
InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
InChI Key:
WOFMFGQZHJDGCX-ZULDAHANSA-N
SMILES:
ClCC(=O)[C@@]1(OC(=O)c2ccco2)[C@H](C)C[C@@H]2[C@]1(C)C[C@H](O)[C@]1([C@H]2CCC2=CC(=O)C=C[C@]12C)Cl
EC Number:
617-501-0
UNII:
04201GDN4R
NSC Number:
746171
Properties
Complexity:
1020  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0
Exact Mass:
520.142g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
521.431g/mol
Monoisotopic Mass:
520.142g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
93.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  
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Acute adrenal crisis in an asthmatic child treated with inhaled fluticasone proprionate. International journal of pediatric endocrinology 20100101
Olfactory cleft inflammation is present in seasonal allergic rhinitis and is reduced with intranasal steroids. American journal of rhinology & allergy 20100101
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Mometasone furoate nasal spray provides early, continuing relief of nasal congestion and improves nasal patency in allergic patients. American journal of rhinology & allergy 20100101
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Topical tacrolimus 0.1% ointment (protopic) reverses nickel contact dermatitis elicited by allergen challenge to a similar degree to mometasone furoate 0.1% with greater suppression of late erythema. Contact dermatitis 20031001
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Randomized, double-masked comparison of olopatadine ophthalmic solution, mometasone furoate monohydrate nasal spray, and fexofenadine hydrochloride tablets using the conjunctival and nasal allergen challenge models. Clinical therapeutics 20030801
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Montelukast as an adjuvant to mainstay therapies in patients with seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20030601
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Topical mometasone furoate for vulvar lichen sclerosus. The Journal of reproductive medicine 20030601
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Patient preferences and sensory comparisons of three intranasal corticosteroids for the treatment of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030501
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An evaluation of short-term corticosteroid response in perennial allergic rhinitis using histamine and adenosine monophosphate nasal challenge. British journal of clinical pharmacology 20030401
A prospective study on the efficacy of mometasone furoate monohydrate aqueous nasal spray on Chinese patients with allergic rhinitis. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20030401
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Systemic bioactivity of intranasal triamcinolone and mometasone in perennial allergic rhinitis. British journal of clinical pharmacology 20030301
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Optimizing treatment with topical tazarotene. American journal of clinical dermatology 20030101
Cutaneous pustular leukemoid reactions in trisomy 21. Pediatric dermatology 20030101
Concentration-dependent effects of mometasone furoate and dexamethasone on foetal lung fibroblast functions involved in airway inflammation and remodeling. Pulmonary pharmacology & therapeutics 20030101
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Practical issues relating to intranasal steroid therapy. Singapore medical journal 20020801
A randomized comparison of the effects of budesonide and mometasone furoate aqueous nasal sprays on nasal peak flow rate and symptoms in perennial allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020601
Instrumental evaluation of retinoid-induced skin irritation. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20020501
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Ethical assessment of industry-sponsored clinical trials: a case analysis. Chest 20020401
Therapeutic efficacy and safety of loratadine syrup in childhood atopic dermatitis treated with mometasone furoate 0.1 per cent cream. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020401
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Topical tacrolimus (FK506) and mometasone furoate in treatment of dyshidrotic palmar eczema: a randomized, observer-blinded trial. Journal of the American Academy of Dermatology 20020101
New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. American journal of clinical dermatology 20020101
A meta-analysis of the dose-response relationship of inhaled corticosteroids in adolescents and adults with mild to moderate persistent asthma. Clinical therapeutics 20020101
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Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophils. Canadian respiratory journal 20020101
Different skin thinning potential of equipotent medium-strength glucocorticoids. Skin pharmacology and applied skin physiology 20020101
Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma. Pulmonary pharmacology & therapeutics 20020101
A clinical evaluation of tazarotene 0.1% gel, with and without a high- or mid-high-potency corticosteroid, in patients with stable plaque psoriasis. Journal of cutaneous medicine and surgery 20020101
Annular elastolytic giant cell granuloma. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society 20020101
Comparison of mometasone furoate administered by metered dose inhaler with beclomethasone dipropionate. International journal of clinical practice 20020101
Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays. Rapid communications in mass spectrometry : RCM 20020101
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High-performance liquid chromatographic analysis of mometasone furoate and its degradation products: application to in vitro degradation studies. Journal of pharmaceutical and biomedical analysis 20010901
Mometason furoate levels. Chest 20010901
A review of the pharmacology and pharmacokinetics of inhaled fluticasone propionate and mometasone furoate. Clinical therapeutics 20010901
Dose-dependent effects of inhaled mometasone furoate on airway function and inflammation after allergen inhalation challenge. American journal of respiratory and critical care medicine 20010815
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Pharmacokinetics of intranasal corticosteroids. The Journal of allergy and clinical immunology 20010701
Effects of intranasal corticosteroids on the hypothalamic-pituitary-adrenal axis in children. The Journal of allergy and clinical immunology 20010701
Assessing the effect of intranasal steroids on growth. The Journal of allergy and clinical immunology 20010701
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Systemic bioavailability of inhaled corticosteroids: appropriate and comparable methodology. The European respiratory journal 20010701
Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20010601
Comparative efficacy and safety of mometasone furoate dry powder inhaler and budesonide Turbuhaler. The European respiratory journal 20010601
Mometasone furoate nasal spray in the treatment of perennial non-allergic rhinitis: a nordic, multicenter, randomized, double-blind, placebo-controlled study. Acta oto-laryngologica 20010601
Dose-ranging study of mometasone furoate dry powder inhaler in the treatment of moderate persistent asthma using fluticasone propionate as an active comparator. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010401
Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010401
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Investigator-masked comparison of tazarotene gel q.d. plus mometasone furoate cream q.d. vs. mometasone furoate cream b.i.d. in the treatment of plaque psoriasis. International journal of dermatology 20010301
Is mometasone furoate aqueous nasal spray (MFNS) effective in reducing symptoms in acute recurrent sinusitis? The Journal of family practice 20010201
Multiple corticosteroid allergies. The Australasian journal of dermatology 20010201
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The response of balanitis xerotica obliterans to local steroid application compared with placebo in children. The Journal of urology 20010101
The role of patient training in the management of seasonal rhinitis and asthma: clinical implications. Allergy 20010101
Effects of monotherapy with intra-nasal corticosteroid or combined oral histamine and leukotriene receptor antagonists in seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20010101
Comparison of once-daily to twice-daily treatment with mometasone furoate dry powder inhaler. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20010101
Psoriasis in a 5-month-old girl with HIV infection. Pediatric dermatology 20010101
Systemic bioavailability of inhaled steroids: the importance of appropriate and comparable methodology. The European respiratory journal 20010101
Topical therapy with fluorinated and non-fluorinated corticosteroids in patients with atopic dermatitis. Journal of the European Academy of Dermatology and Venereology : JEADV 20010101
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Clinical prescribing of allergic rhinitis medication in the preschool and young school-age child: what are the options? BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20010101
The effectiveness of wet wrap dressings using 0.1% mometasone furoate and 0.005% fluticasone proprionate ointments in the treatment of moderate to severe atopic dermatitis in children. Pediatric dermatology 20010101
Simultaneous onset of psoriasis vulgaris in monozygotic twins. American journal of clinical dermatology 20010101
Drug delivery performance of the mometasone furoate dry powder inhaler. Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine 20010101
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Regulation of the action of hydrocortisone in airway epithelial cells by 11beta-hydroxysteroid dehydrogenase. American journal of respiratory cell and molecular biology 19990901
Inhibition of VCAM-1 expression in human bronchial epithelial cells by glucocorticoids. American journal of respiratory cell and molecular biology 19990401
Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors. The Journal of allergy and clinical immunology 19981101
Comparison of the local and systemic side effects of methylprednisolone aceponate and mometasone furoate applied as ointments with equal antiinflammatory activity. Journal of the American Academy of Dermatology 19931001
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