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AT9283

CAS No.:
896466-04-9
Catalog Number:
AG003699
Molecular Formula:
C19H23N7O2
Molecular Weight:
381.4316
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$264
- +
10mg
≥98%
1 week
United States
$408
- +
25mg
≥98%
1 week
United States
$761
- +
50mg
≥98%
1 week
United States
$1050
- +
Product Description
Catalog Number:
AG003699
Chemical Name:
AT9283
CAS Number:
896466-04-9
Molecular Formula:
C19H23N7O2
Molecular Weight:
381.4316
MDL Number:
MFCD12031513
IUPAC Name:
1-cyclopropyl-3-[5-[6-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl]urea
InChI:
InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27)
InChI Key:
LOLPPWBBNUVNQZ-UHFFFAOYSA-N
SMILES:
O=C(Nc1c[nH]nc1c1nc2c([nH]1)ccc(c2)CN1CCOCC1)NC1CC1
UNII:
XAV9KYN9WL
Properties
Complexity:
554  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
381.191g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
381.44g/mol
Monoisotopic Mass:
381.191g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
111A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.5  
Literature
Title Journal
AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. International journal of cancer 20120615
A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies. Annals of oncology : official journal of the European Society for Medical Oncology 20120501
Effects of the novel aurora kinase/JAK inhibitor, AT9283 and imatinib on Philadelphia positive cells in vitro. Blood cells, molecules & diseases 20120315
Adaptation of the plasma inhibitory activity assay to detect Aurora, ABL and FLT3 kinase inhibition by AT9283 in pediatric leukemia. Leukemia research 20110901
Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clinical cancer research : an official journal of the American Association for Cancer Research 20110515
AT-9283, a small-molecule multi-targeted kinase inhibitor for the potential treatment of cancer. Current opinion in investigational drugs (London, England : 2000) 20101201
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells. Blood 20100923
AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders. British journal of haematology 20100701
Aurora kinase inhibitors as anti-cancer therapy. Anti-cancer drugs 20100401
Aurora B kinase inhibition in mitosis: strategies for optimising the use of aurora kinase inhibitors such as AT9283. Cell cycle (Georgetown, Tex.) 20090615
Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. Journal of medicinal chemistry 20090122
Properties