Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD.

Journal of the American Society of Nephrology : JASN 20120928

Antidiuretic hormone antagonist to reduce cystine stone formation.

Annals of internal medicine 20120918

[Hyponatremia : The water-intolerant patient].

Medizinische Klinik, Intensivmedizin und Notfallmedizin 20120901

Update on tolvaptan for the treatment of hyponatremia.

Expert review of pharmacoeconomics & outcomes research 20120801

Chronic administration of oral vasopressin type 2 receptor antagonist tolvaptan exerts both myocardial and renal protective effects in rats with hypertensive heart failure.

Circulation. Heart failure 20120701

Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment.

Journal of cardiovascular medicine (Hagerstown, Md.) 20120701

Serum and urine responses to the aquaretic agent tolvaptan in hospitalized hyponatremic patients.

International urology and nephrology 20120601

Diagnosis and management of hyponatremia in cancer patients.

The oncologist 20120601

A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial.

Heart failure reviews 20120501

Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug.

Journal of neurology, neurosurgery, and psychiatry 20120501

Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.

Clinical journal of the American Society of Nephrology : CJASN 20120501

[A case of venlafaxine-induced syndrome of inappropriate ADH secretion (SIADH) - treatment with tolvaptan].

Deutsche medizinische Wochenschrift (1946) 20120501

[Diagnostics and new treatment methods of syndrome of inappropriate antidiuretic hormone secretion (SIADH)].

Ugeskrift for laeger 20120409

[SIADH - a 'shambles'].

Ugeskrift for laeger 20120409

Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects.

British journal of clinical pharmacology 20120401

Pharmacokinetics and pharmacodynamics of oral tolvaptan administered in 15- to 60-mg single doses to healthy Korean men.

Journal of cardiovascular pharmacology 20120401

Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics.

Journal of neuroendocrinology 20120401

Vaptans: a potential new approach for treating chronic hyponatremia in psychotic patients.

Clinical schizophrenia & related psychoses 20120401

[SIADH and vaptans].

Annales d'endocrinologie 20120401

Medical therapy for acute decompensated heart failure: what recent clinical trials have taught us about diuretics and vasodilators.

Current heart failure reports 20120301

Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis.

Journal of hepatology 20120301

Polycystic kidney disease: a 2011 update.

Current opinion in nephrology and hypertension 20120301

Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial.

European journal of heart failure 20120301

Hyponatremia, heart failure, and the role of tolvaptan.

Postgraduate medicine 20120301

Considerations regarding the management of hyponatraemia secondary to SIADH.

Best practice & research. Clinical endocrinology & metabolism 20120301

Perspectives on the management of hyponatraemia secondary to SIADH across Europe.

Best practice & research. Clinical endocrinology & metabolism 20120301

Revision and update on clinical practice guideline for liver cirrhosis.

The Korean journal of hepatology 20120301

Effect of grapefruit juice on the pharmacokinetics of tolvaptan, a non-peptide arginine vasopressin antagonist, in healthy subjects.

European journal of clinical pharmacology 20120201

Absolute bioavailability of tolvaptan and determination of minimally effective concentrations in healthy subjects.

International journal of clinical pharmacology and therapeutics 20120201

Evaluation of costs associated with tolvaptan-mediated hospital length of stay reduction among US patients with the syndrome of inappropriate antidiuretic hormone secretion, based on SALT-1 and SALT-2 trials.

Hospital practice (1995) 20120201

V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists.

The Journal of biological chemistry 20120113

Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.

Journal of intensive care medicine 20120101

Tolvaptan.

British journal of clinical pharmacology 20120101

Massive aquaresis after tolvaptan administration and albumin infusion in a patient with alcoholic cirrhosis.

The American journal of medicine 20120101

Evaluation of costs associated with tolvaptan-mediated length-of-stay reduction among heart failure patients with hyponatremia in the US, based on the EVEREST trial.

Journal of medical economics 20120101

Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects.

Nephron. Clinical practice 20120101

The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department.

BMC medicine 20120101

[Hyponatremic syndrome].

La Clinica terapeutica 20120101

Preliminary report of tolvaptan treatment in Japanese patients with heart failure.

International heart journal 20120101

Vasopressin receptor antagonists and their role in clinical medicine.

Indian journal of endocrinology and metabolism 20120101

[Tolvaptan and CKD, a balance is needed: promises and problems of new drugs in a moment of crisis].

Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20120101

Long-term treatment of hyponatremic patients with nephrogenic syndrome of inappropriate antidiuresis: personal experience and review of published case reports.

Nephron. Clinical practice 20120101

Hyponatremia in cirrhosis and end-stage liver disease: treatment with the vasopressin V₂-receptor antagonist tolvaptan.

Digestive diseases and sciences 20120101

Vasopressin receptor antagonist in the treatment of the syndrome of inappropriate antidiuretic hormone in general hospital practice.

Endocrine journal 20120101

[Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?].

Wiadomosci lekarskie (Warsaw, Poland : 1960) 20120101

Tolvaptan for heart failure patients with volume overload.

Cardiovascular drugs and therapy 20111201

High sensitivity to tolvaptan in paraneoplastic syndrome of inappropriate ADH secretion (SIADH).

Annals of oncology : official journal of the European Society for Medical Oncology 20111201

Vasopressin V1 receptor-mediated aldosterone production as a result of selective V2 receptor antagonism: a potential explanation for the failure of tolvaptan to reduce cardiovascular outcomes in the EVEREST trial.

European journal of heart failure 20111201

Tolvaptan for the treatment of hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion.

Expert review of cardiovascular therapy 20111201

[Disorders of fluid and electrolyte balance].

Deutsche medizinische Wochenschrift (1946) 20111201

Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers.

Cardiovascular drugs and therapy 20111201

Effects of tolvaptan on volume overload in Japanese patients with heart failure: results of a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.

Cardiovascular drugs and therapy 20111201

Efficacy and safety of tolvaptan in heart failure patients with volume overload despite the standard treatment with conventional diuretics: a phase III, randomized, double-blind, placebo-controlled study (QUEST study).

Cardiovascular drugs and therapy 20111201

Efficacy and safety of tolvaptan in heart failure patients with sustained volume overload despite the use of conventional diuretics: a phase III open-label study.

Cardiovascular drugs and therapy 20111201

Phase III clinical pharmacology study of tolvaptan.

Cardiovascular drugs and therapy 20111201

Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure.

Cardiovascular drugs and therapy 20111201

Anti-edematous effects of tolvaptan in experimental rodent models.

Cardiovascular drugs and therapy 20111201

Nonclinical safety profile of tolvaptan.

Cardiovascular drugs and therapy 20111201

Nonclinical pharmacokinetics of a new nonpeptide V2 receptor antagonist, tolvaptan.

Cardiovascular drugs and therapy 20111201

A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide and the combination of tolvaptan and furosemide in patients with heart failure and systolic dysfunction.

Journal of cardiac failure 20111201

Controlling the flood gates: vaptans, furosemide and the quest for a renal protective diuresis.

Journal of cardiac failure 20111201

Methyl 5-chloro-2-nitro-benzoate.

Acta crystallographica. Section E, Structure reports online 20111201

V2 receptor antagonist; tolvaptan.

Electrolyte & blood pressure : E & BP 20111201

Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.

American journal of physiology. Renal physiology 20111101

[Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].

Presse medicale (Paris, France : 1983) 20111101

[Tolvaptan (vasopressin receptor antagonist)].

Nihon rinsho. Japanese journal of clinical medicine 20111101

[Tolvaptan in antidiuretic hormone secretion syndrome secondary to treatment with citalopram].

Revista clinica espanola 20111001

Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial.

European heart journal 20111001

Worsening kidney function in decompensated heart failure: treat the heart, don't mind the kidney.

European heart journal 20111001

Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience.

Clinical journal of the American Society of Nephrology : CJASN 20111001

Renal dysfunction in acute heart failure.

Korean circulation journal 20111001

Neuro-endocrine regulation of blood pressure.

Indian journal of endocrinology and metabolism 20111001

[The efficacy and safety of tolvaptan on treating heart failure patients with hyponatremia].

Zhonghua xin xue guan bing za zhi 20111001

Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists?

Current heart failure reports 20110901

Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet.

Kidney international 20110901

Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease.

Kidney international 20110801

The therapeutic use of vaptans for the treatment of dilutional hyponatremia.

Journal of pharmacy practice 20110801

[Practical approach to hyponatremia].

Deutsche medizinische Wochenschrift (1946) 20110801

Hyponatremia in hospitalized patients: the potential role of tolvaptan.

Hospital practice (1995) 20110801

Tolvaptan inhibition of desmopressin effects on coagulation factors in a patient with decreased von Willebrand factor and polycystic kidney disease.

Blood 20110714

Identifying patients hospitalized with heart failure at risk for unfavorable future quality of life.

Circulation. Cardiovascular quality and outcomes 20110701

[Heart and kidney failure combined. Trouble seldom comes alone].

MMW Fortschritte der Medizin 20110630

Effects of tolvaptan on physician-assessed symptoms and signs in patients hospitalized with acute heart failure syndromes: analysis from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan (EVEREST) trials.

American heart journal 20110601

In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects.

Journal of clinical pharmacology 20110501

Tolvaptan: a new therapeutic agent.

Reviews on recent clinical trials 20110501

Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion.

European journal of endocrinology 20110501

Rationale and design of the TEMPO (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and its Outcomes) 3-4 Study.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20110501

Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH).

European journal of clinical pharmacology 20110401

Tolvaptan for the treatment of heart failure: a review of the literature.

Expert opinion on pharmacotherapy 20110401

[Treatment of hyponatremia: new developments and controversies].

Deutsche medizinische Wochenschrift (1946) 20110401

New drugs for hyponatraemia. Cost effectiveness of tolvaptan.

BMJ (Clinical research ed.) 20110329

Hyponatremia: vasopressin antagonists in hyponatremia: more data needed.

Nature reviews. Nephrology 20110301

Hyponatremia: diagnosis, complications, and management including V2 receptor antagonists.

Current opinion in nephrology and hypertension 20110301

Vaptans for the treatment of hyponatremia.

Nature reviews. Endocrinology 20110301

Effect of serum sodium concentration and tolvaptan treatment on length of hospitalization in patients with heart failure.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110215

Hepatic alteration after treatment using tolvaptan.

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101

The cardiorenal syndrome: making the connection.

International journal of nephrology 20110101

Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/V1a receptor blockade in a preclinical heart failure model.

American journal of therapeutics 20110101

Therapeutic options for the management of the cardiorenal syndrome.

International journal of nephrology 20110101

The cardiorenal syndrome: a review.

International journal of nephrology 20110101

Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy.

Journal of biomedicine & biotechnology 20110101

Cardiorenal syndrome in acute heart failure syndromes.

International journal of nephrology 20110101

Hyponatremia and congestive heart failure: a marker of increased mortality and a target for therapy.

International journal of nephrology 20110101

Tolvaptan for the management of syndrome of inappropriate antidiuretic hormone secretion: lessons learned in titration of dose.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Cause of seizures: Lungs, not the brain.

Lung India : official organ of Indian Chest Society 20110101

Pharmacological management of cardiorenal syndromes.

International journal of nephrology 20110101

Tolvaptan, hyponatremia, and heart failure.

International journal of nephrology and renovascular disease 20110101

Management of renal failure and ascites in patients with cirrhosis.

International journal of hepatology 20110101

Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.

PloS one 20110101

[Treatment of hyponatremia: role of vaptans].

Der Internist 20101201

New drugs for hyponatraemia.

BMJ (Clinical research ed.) 20101115

Targeting B-Raf as a treatment strategy for polycystic kidney disease.

American journal of physiology. Renal physiology 20101101

Hyponatremia in acute decompensated heart failure: mechanisms, prognosis, and treatment options.

Clinical cardiology 20101101

Arginine vasopressin receptor antagonists (vaptans): pharmacological tools and potential therapeutic agents.

Drug discovery today 20101001

Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study.

European journal of heart failure 20101001

Tolvaptan: any evidence of efficacy in SIADH?

Prescrire international 20101001

A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis.

Journal of gastroenterology 20100901

Tolvaptan: a vasopressin antagonist for the management of euvolemic and hypervolemic hyponatremia.

Expert review of clinical pharmacology 20100901

Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20100801

Chronic hyponatremia impairs memory in rats: effects of vasopressin antagonist tolvaptan.

The Journal of endocrinology 20100701

Vasopressin-receptor antagonists.

Future cardiology 20100701

The assessment and treatment of water imbalance in patients with psychosis.

Clinical schizophrenia & related psychoses 20100701

Treatment options for hyponatremia in heart failure.

Congestive heart failure (Greenwich, Conn.) 20100701

The syndrome of inappropriate antidiuretic hormone: current and future management options.

European journal of endocrinology 20100601

Hyponatraemia: new associations and new treatments.

European journal of endocrinology 20100601

Hyponatremia: Prolonged use of the vasopressin antagonist tolvaptan is a safe and effective treatment for hyponatremia.

Nature reviews. Nephrology 20100601

Treatment of hypervolemic or euvolemic hyponatremia associated with heart failure, cirrhosis, or the syndrome of inappropriate antidiuretic hormone with tolvaptan: a clinical review.

Clinical therapeutics 20100601

Renal and anti-aldosterone actions of vasopressin-2 receptor antagonism and B-type natriuretic peptide in experimental heart failure.

Circulation. Heart failure 20100501

Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program.

American heart journal 20100501

The critical link of hypervolemia and hyponatremia in heart failure and the potential role of arginine vasopressin antagonists.

Journal of cardiac failure 20100501

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20100501

[Hyponatremia in heart failure: physiopathology and pharmacological approach].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100501

[Vasopressin receptor antagonists: the vaptans].

Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20100501

Treatment of chronic hyponatremia: now we know how, but do we know when or if?

Journal of the American Society of Nephrology : JASN 20100401

Oral tolvaptan is safe and effective in chronic hyponatremia.

Journal of the American Society of Nephrology : JASN 20100401

Critical elements of clinical follow-up after hospital discharge for heart failure: insights from the EVEREST trial.

European journal of heart failure 20100401

Vasopressin antagonists: Pharmacotherapy for the treatment of heart failure.

The Annals of pharmacotherapy 20100401

Tolvaptan.

Drugs 20100305

Cardio-renal syndromes: report from the consensus conference of the acute dialysis quality initiative.

European heart journal 20100301

Tolvaptan: a new tool for the effective treatment of hyponatremia in psychotic disorders.

Expert opinion on pharmacotherapy 20100301

Treatment strategies and clinical trial design in ADPKD.

Advances in chronic kidney disease 20100301

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20100301

Tolvaptan for the treatment of hyponatremia and congestive heart failure.

Drugs of today (Barcelona, Spain : 1998) 20100301

New Drugs2010, PART 1.

Nursing 20100201

Tolvaptan and hyponatremia in a patient with cirrhosis.

Hepatology (Baltimore, Md.) 20100201

Hyponatremia: evaluation and management.

Hospital practice (1995) 20100201

Potential of endothelin-1 and vasopressin antagonists for the treatment of congestive heart failure.

Heart failure reviews 20100101

Biomarkers in acute myocardial infarction.

BMC medicine 20100101

Hyponatremia: mechanisms and newer treatments.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101

Cyst formation in the PKD2 (1-703) transgenic rat precedes deregulation of proliferation-related pathways.

BMC nephrology 20100101

Novel agents for the treatment of hyponatremia: a review of conivaptan and tolvaptan.

Cardiology in review 20100101

Treatment of euvolemic hyponatremia in the intensive care unit by urea.

Critical care (London, England) 20100101

Age- and gender-specific risk of death after first hospitalization for heart failure.

BMC public health 20100101

Clinical utility of tolvaptan in the management of hyponatremia in heart failure patients.

International journal of nephrology and renovascular disease 20100101

Polycystic kidney disease: inheritance, pathophysiology, prognosis, and treatment.

International journal of nephrology and renovascular disease 20100101

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20091201

Renal dysfunction in patients with chronic liver disease.

Electrolyte & blood pressure : E & BP 20091201

Tolvaptan (Samsca) for hyponatremia.

The Medical letter on drugs and therapeutics 20091130

[Vasopressin receptor antagonists and heart failure].

Therapeutische Umschau. Revue therapeutique 20091101

[Treating hyponatraemia--not an easy task].

Therapeutische Umschau. Revue therapeutique 20091101

Tolvaptan, a selective oral vasopressin V2 receptor antagonist, ameliorates podocyte injury in puromycin aminonucleoside nephrotic rats.

Clinical and experimental nephrology 20091001

Effects of tolvaptan on dyspnoea relief from the EVEREST trials.

European heart journal 20090901

Autosomal dominant polycystic kidney disease: 2009 update for internists.

The Korean journal of internal medicine 20090901

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20090901

Tolvaptan.

Nature reviews. Drug discovery 20090801

Weight changes after hospitalization for worsening heart failure and subsequent re-hospitalization and mortality in the EVEREST trial.

European heart journal 20090701

FDA approves oral vasopressin antagonist.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090701

Hyponatremia in heart failure.

Heart failure reviews 20090601

Pharmacology of vasopressin antagonists.

Heart failure reviews 20090601

Treatment options for hyponatremia in heart failure.

Heart failure reviews 20090601

Introduction: Vasopressin therapy.

Heart failure reviews 20090601

The vaptans ante portas: a status report.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090501

Hyponatremia: case vignettes.

Seminars in nephrology 20090501

Multinational trials: lost in translation?

Clinical and translational science 20090401

Pharmacotherapy of acute and chronic heart failure: part 2.

Current heart failure reports 20090301

Advances in the pathogenesis and treatment of polycystic kidney disease.

Current opinion in nephrology and hypertension 20090301

Vasopressin and vasopressin receptor antagonists in heart failure.

Cardiology in review 20090101

New drugs: tapentadol hydrochloride, tolvaptan, and benzyl alcohol.

Journal of the American Pharmacists Association : JAPhA 20090101

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20090101

Hyponatremia in heart failure.

Journal of intensive care medicine 20090101

Conivaptan and its role in the treatment of hyponatremia.

Drug design, development and therapy 20090101

Long-term outcomes in a family with nephrogenic syndrome of inappropriate antidiuresis.

International journal of pediatric endocrinology 20090101

Conivaptan: Evidence supporting its therapeutic use in hyponatremia.

Core evidence 20090101

Cardiorenal syndrome.

F1000 medicine reports 20090101

Double-blind, placebo-controlled, multicenter trial of a vasopressin V2-receptor antagonist in patients with schizophrenia and hyponatremia.

Biological psychiatry 20081215

Tolvaptan and its potential in the treatment of hyponatremia.

Therapeutics and clinical risk management 20081201

Continental differences in clinical characteristics, management, and outcomes in patients hospitalized with worsening heart failure results from the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan) program.

Journal of the American College of Cardiology 20081111

Acute hemodynamic effects of tolvaptan, a vasopressin V2 receptor blocker, in patients with symptomatic heart failure and systolic dysfunction: an international, multicenter, randomized, placebo-controlled trial.

Journal of the American College of Cardiology 20081104

Management of heart failure: a brief review and selected update.

Cardiology clinics 20081101

EVEREST study: Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan.

Expert review of cardiovascular therapy 20081101

[Etiology, diagnostics and therapy of hyponatremias].

Orvosi hetilap 20080720

Role of vasopressin antagonists.

Clinical journal of the American Society of Nephrology : CJASN 20080701

Clinical implications of QRS duration in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction.

JAMA 20080611

Role of tolvaptan in acute decompensated heart failure.

Expert review of cardiovascular therapy 20080601

Vasopressin and vasopressin antagonists in heart failure and hyponatremia.

Current heart failure reports 20080601

Tolvaptan: the evidence for its therapeutic value in acute heart failure syndrome.

Core evidence 20080601

Vasopressin-receptor antagonists in heart failure.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080501

Vasopressin antagonists in polycystic kidney disease.

Seminars in nephrology 20080501

Conivaptan: a step forward in the treatment of hyponatremia?

Therapeutics and clinical risk management 20080401

Effects of V2-receptor antagonist tolvaptan and the loop diuretic furosemide in rats with heart failure.

Biochemical pharmacology 20080315

New therapies in acute decompensated heart failure.

Current opinion in cardiology 20080301

Therapeutic interventions for autosomal dominant polycystic kidney disease.

Nephrology news & issues 20080301

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.

Cellular and molecular life sciences : CMLS 20080201

[Highlights 2007 in hospital-based internal medicine: the point of view from the chief residents].

Revue medicale suisse 20080130

Highlights of the 2007 Scientific Meeting of the Heart Failure Society of America: Washington, DC, September 16-19, 2007.

Journal of the American College of Cardiology 20080122

Hyponatremia in psychiatric patients: update on evaluation and management.

Harvard review of psychiatry 20080101

Vasopressin in vasodilatory shock: is the heart in danger?

Critical care (London, England) 20080101

Mechanisms, risks, and new treatment options for hyponatremia.

Cardiology 20080101

Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents.

Progress in brain research 20080101

Diagnosis and management of hyponatremia in cancer patients.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20071201

Pharmacokinetics, pharmacodynamics, and safety of tolvaptan, a nonpeptide AVP antagonist, during ascending single-dose studies in healthy subjects.

Journal of clinical pharmacology 20071201

Aminocarbonylation route to tolvaptan.

Bioorganic & medicinal chemistry letters 20071201

Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.

Cardiovascular drugs and therapy 20071201

Tolvaptan, an oral vasopressin V2 receptor antagonist for heart failure?

American journal of kidney diseases : the official journal of the National Kidney Foundation 20071201

Effects of nonpeptide vasopressin V2 antagonist tolvaptan in rats with heart failure.

Biochemical pharmacology 20071115

Hyponatremia and vasopressin antagonism in congestive heart failure.

Clinical cardiology 20071101

Current issues for nurse practitioners: Hyponatremia.

Journal of the American Academy of Nurse Practitioners 20071101

V2 receptor antagonism with tolvaptan in heart failure.

Expert opinion on investigational drugs 20071001

Water in health and disease: new aspects of disturbances in water metabolism.

The Netherlands journal of medicine 20071001

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20071001

Effects of tolvaptan, an oral vasopressin V2 receptor antagonist, in hyponatremia.

American journal of kidney diseases : the official journal of the National Kidney Foundation 20070801

Pharmacokinetic and pharmacodynamic interaction between tolvaptan, a non-peptide AVP antagonist, and furosemide or hydrochlorothiazide.

Journal of cardiovascular pharmacology 20070801

[Vasopressin antagonists in treatment of hyponatremia].

Polskie Archiwum Medycyny Wewnetrznej 20070801

Multicenter, randomized, double-blind, placebo-controlled study on the effect of oral tolvaptan on left ventricular dilation and function in patients with heart failure and systolic dysfunction.

Journal of the American College of Cardiology 20070605

Arginine vasopressin receptor antagonists for heart failure: a winter climbing to the Everest's tip?

Journal of the American College of Cardiology 20070605

Vaptans: a promising therapy in the management of advanced cirrhosis.

Journal of hepatology 20070601

[Recent progress in vasopressin research on cardiovascular diseases].

Rinsho byori. The Japanese journal of clinical pathology 20070601

[Vasopressin V2-receptor antagonist, tolvaptan, for treatment of heart failure].

Nihon rinsho. Japanese journal of clinical medicine 20070528

Hyponatremia: current treatment strategies and the role of vasopressin antagonists.

The Annals of pharmacotherapy 20070501

What new drugs can nephrologists look forward to in the next year or two?

Nature clinical practice. Nephrology 20070501

Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial.

JAMA 20070328

Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials.

JAMA 20070328

Climbing the mountain of acute decompensated heart failure: the EVEREST Trials.

JAMA 20070328

Tolvaptan for hyponatremia.

The New England journal of medicine 20070301

Tolvaptan for hyponatremia.

The New England journal of medicine 20070301

Tolvaptan for hyponatremia.

The New England journal of medicine 20070301

Tolvaptan for hyponatremia.

The New England journal of medicine 20070301

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology 20070301

Nephrogenic syndrome of inappropriate antidiuresis in adults: high phenotypic variability in men and women from a large pedigree.

Journal of the American Society of Nephrology : JASN 20070201

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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070201

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Nature clinical practice. Nephrology 20070201

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European journal of heart failure 20070101

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Neurocritical care 20070101

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European journal of heart failure 20070101

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Gateways to clinical trials.

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The American journal of cardiology 20061201

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The New England journal of medicine 20061116

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A flexible approach for the preparation of substituted benzazepines: application to the synthesis of tolvaptan.

Bioorganic & medicinal chemistry 20060915

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Cleveland Clinic journal of medicine 20060901

Gateways to clinical trials.

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Kidney international 20060601

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Cleveland Clinic journal of medicine 20060601

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The American journal of cardiology 20060401

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American journal of physiology. Renal physiology 20060201

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The American journal of cardiology 20050919

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Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias.

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Combination pharmacologic therapies for heart failure: what next after angiotensin-converting enzyme inhibitors and beta-blockers?

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Endocrinology 20050701

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V2 receptor antagonists in cystic kidney diseases: an exciting step towards a practical treatment.

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Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

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Trial finds tolvaptan may help manage congestion in people with heart failure, but did not reduce death or hospitalisation.

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A new class of heart failure drugs? Tolvaptan could be a welcome helper for 'water pills' and their potentially serious side effects.

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Rofecoxib use increases acute myocardial infarction risk.

Circulation 20040504

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JAMA 20040428

American Heart Association scientific sessions.

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New drug fights fluid build-up. Medication may relieve a common heart failure symptom.

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Rationale and study design for a multicenter, randomized, double-blind, placebo-controlled study of the effects of tolvaptan on the acute and chronic outcomes of patients hospitalized with worsening congestive heart failure.

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Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats.

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