Home Other Building Blocks Acotiamide hydrochloride

Acotiamide hydrochloride

CAS No.:
185104-11-4
Catalog Number:
AG00363O
Molecular Formula:
C21H31ClN4O5S
Molecular Weight:
487.0126
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
98%
1 week
United States
$31
- +
Product Description
Catalog Number:
AG00363O
Chemical Name:
Acotiamide hydrochloride
CAS Number:
185104-11-4
Molecular Formula:
C21H31ClN4O5S
Molecular Weight:
487.0126
MDL Number:
MFCD23103502
IUPAC Name:
N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide;hydrochloride
InChI:
InChI=1S/C21H30N4O5S.ClH/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26;/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27);1H
InChI Key:
VQEKQYLTAIVCBW-UHFFFAOYSA-N
SMILES:
COc1cc(O)c(cc1OC)C(=O)Nc1scc(n1)C(=O)NCCN(C(C)C)C(C)C.Cl
UNII:
510791NN30
Properties
Complexity:
586  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
486.17g/mol
Formal Charge:
0
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
487.012g/mol
Monoisotopic Mass:
486.17g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
141A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Acotiamide, a novel gastroprokinetic for the treatment of patients with functional dyspepsia: postprandial distress syndrome. Expert review of gastroenterology & hepatology 20120901
A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. Gut 20120601
New hope for functional dyspepsia? Gut 20120601
Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120601
Acotiamide, a new orally active acetylcholinesterase inhibitor, stimulates gastrointestinal motor activity in conscious dogs. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120601
Mechanism for distribution of acotiamide, a novel gastroprokinetic agent for the treatment of functional dyspepsia, in rat stomach. Journal of pharmaceutical sciences 20111101
Acotiamide hydrochloride (Z-338) enhances gastric motility and emptying by inhibiting acetylcholinesterase activity in rats. European journal of pharmacology 20110901
Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia. Expert opinion on investigational drugs 20110501
Acotiamide hydrochloride (Z-338), a new selective acetylcholinesterase inhibitor, enhances gastric motility without prolonging QT interval in dogs: comparison with cisapride, itopride, and mosapride. The Journal of pharmacology and experimental therapeutics 20110301
A long-term study of acotiamide in patients with functional dyspepsia: results from an open-label phase III trial in Japan on efficacy, safety and pattern of administration. Digestion 20110101
Clinical trial: dose-dependent therapeutic efficacy of acotiamide hydrochloride (Z-338) in patients with functional dyspepsia - 100 mg t.i.d. is an optimal dosage. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100601
Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100601
Effects of Z-338, a novel gastroprokinetic agent, on the actions of excitatory and inhibitory neurotransmitters on neurons in area postrema. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101
A dose-ranging, placebo-controlled, pilot trial of Acotiamide in patients with functional dyspepsia. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20090301
Acotiamide hydrochloride (Z-338), a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080901
Characterization of functional effects of Z-338, a novel gastroprokinetic agent, on the muscarinic M1, M2, and M3 receptors expressed in Xenopus oocytes. European journal of pharmacology 20041128
Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338. European journal of pharmacology 20040823
Z-338. Zeria/Yamanouchi. Current opinion in investigational drugs (London, England : 2000) 20040701
Possible involvement of M5 muscarinic receptor in the enhancing actions of the novel gastroprokinetic agent Z-338 on nifedipine-sensitive voltage-dependent Ca2+ currents in guinea pig stomach. Japanese journal of pharmacology 20020801
An electrophysiological study of muscarinic and nicotinic receptors of rat paratracheal ganglion neurons and their inhibition by Z-338. British journal of pharmacology 20020301
LC determination of Z-338, novel gastroprokinetic agent in dog plasma by SCX solid phase extraction. Journal of pharmaceutical and biomedical analysis 20010601
Properties