Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120601

Proteomics analysis of aromatic catabolic pathways in thermophilic Geobacillus thermodenitrificans NG80-2.

Journal of proteomics 20120202

Divergence and convergence in enzyme evolution.

The Journal of biological chemistry 20120102

Chemotaxis of Burkholderia sp. strain SJ98 towards chloronitroaromatic compounds that it can metabolise.

BMC microbiology 20120101

Modulation of tumor tolerance in primary central nervous system malignancies.

Clinical & developmental immunology 20120101

Quinolinic Acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms.

International journal of tryptophan research : IJTR 20120101

Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).

PloS one 20120101

Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases.

Frontiers in immunology 20120101

Comparative genotoxicity of 3-hydroxyanthranilic acid and anthranilic acid in the presence of a metal cofactor Cu (II) in vitro.

Mutation research 20111224

Differential action of 3-hydroxyanthranilic acid on viability and activation of stimulated lymphocytes.

International immunopharmacology 20111201

Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.

Schizophrenia bulletin 20111101

Tryptophan in alcoholism treatment II: inhibition of the rat liver mitochondrial low Km aldehyde dehydrogenase activity, elevation of blood acetaldehyde concentration and induction of aversion to alcohol by combined administration of tryptophan and benserazide.

Alcohol and alcoholism (Oxford, Oxfordshire) 20111101

Tryptophan in alcoholism treatment I: kynurenine metabolites inhibit the rat liver mitochondrial low Km aldehyde dehydrogenase activity, elevate blood acetaldehyde concentration and induce aversion to alcohol.

Alcohol and alcoholism (Oxford, Oxfordshire) 20111101

Effect of some naturally occurring iron ion chelators on the formation of radicals in the reaction mixtures of rat liver microsomes with ADP, Fe and NADPH.

Journal of clinical biochemistry and nutrition 20111101

The mechanism of formation of N-formylkynurenine by heme dioxygenases.

Journal of the American Chemical Society 20111012

Kynurenine metabolism predicts cognitive function in patients following cardiac bypass and thoracic surgery.

Journal of neurochemistry 20111001

The tryptophan metabolite 3-hydroxyanthranilic acid plays anti-inflammatory and neuroprotective roles during inflammation: role of hemeoxygenase-1.

The American journal of pathology 20110901

Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives.

Current neuropharmacology 20110601

2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells.

Proceedings of the Japan Academy. Series B, Physical and biological sciences 20110511

Caffeic acid inhibits the formation of 1-hydroxyethyl radical in the reaction mixture of rat liver microsomes with ethanol partly through its metal chelating activity.

Journal of clinical biochemistry and nutrition 20110501

3-hydroxykynurenine suppresses CD4+ T-cell proliferation, induces T-regulatory-cell development, and prolongs corneal allograft survival.

Investigative ophthalmology & visual science 20110401

Multiple multi-copper oxidase gene families in basidiomycetes - what for?

Current genomics 20110401

Possible roles of excess tryptophan metabolites in cancer.

Environmental and molecular mutagenesis 20110301

Assessment of vitamin B(6) status in Korean patients with newly diagnosed type 2 diabetes.

Nutrition research and practice 20110201

Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity.

The Journal of biological chemistry 20110107

Studies of complex biological systems with applications to molecular medicine: the need to integrate transcriptomic and proteomic approaches.

Journal of biomedicine & biotechnology 20110101

Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder.

Depression research and treatment 20110101

Fluorescent derivatization of xanthurenic acid and nicotinic acid with horseradish peroxidase in the presence of excess hydrogen peroxide.

Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20110101

The relationship between indoleamine 2,3-dioxygenase activity and post-stroke cognitive impairment.

Journal of neuroinflammation 20110101

Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO).

PloS one 20110101

Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis.

BMC medical genetics 20110101

The involvement of neuroinflammation and kynurenine pathway in Parkinson's disease.

Parkinson's disease 20110101

Role of dendritic cells in the induction of regulatory T cells.

Cell & bioscience 20110101

An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.

PloS one 20110101

A biological pathway linking inflammation and depression: activation of indoleamine 2,3-dioxygenase.

Neuropsychiatric disease and treatment 20110101

The homeostasis of iron, copper, and zinc in paracoccidioides brasiliensis, cryptococcus neoformans var. Grubii, and cryptococcus gattii: a comparative analysis.

Frontiers in microbiology 20110101

Pathobiology and chemoprevention of bladder cancer.

Journal of oncology 20110101

Effects of pro-inflammatory cytokines on expression of kynurenine pathway enzymes in human dermal fibroblasts.

Journal of inflammation (London, England) 20110101

3-Hydroxy kynurenine treatment controls T. cruzi replication and the inflammatory pathology preventing the clinical symptoms of chronic Chagas disease.

PloS one 20110101

Enhanced peptide quantification using spectral count clustering and cluster abundance.

BMC bioinformatics 20110101

Manganese superoxide dismutase: guardian of the powerhouse.

International journal of molecular sciences 20110101

Inducible ASABF-type antimicrobial peptide from the sponge Suberites domuncula: microbicidal and hemolytic activity in vitro and toxic effect on molluscs in vivo.

Marine drugs 20110101

Redox-based inactivation of cysteine cathepsins by compounds containing the 4-aminophenol moiety.

PloS one 20110101

Tryptophan oxidative metabolism catalyzed by geobacillus stearothermophilus: a thermophile isolated from kuwait soil contaminated with petroleum hydrocarbons.

International journal of tryptophan research : IJTR 20110101

Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons.

International journal of tryptophan research : IJTR 20110101

The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance.

Clinical & developmental immunology 20110101

Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System.

International journal of Alzheimer's disease 20110101

Aromatic C-methyltransferases with antipodal stereoselectivity for structurally diverse phenolic amino acids catalyze the methylation step in the biosynthesis of the actinomycin chromophore.

Biochemistry 20101116

The role of tryptophan catabolism along the kynurenine pathway in acute ischemic stroke.

Neurochemical research 20100901

3-hydroxyanthranilic acid is independently associated with monocyte chemoattractant protein-1 (CCL2) and macrophage inflammatory protein-1beta (CCL4) in patients with chronic kidney disease.

Clinical biochemistry 20100901

Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii.

PLoS genetics 20100901

Melatonin metabolism in the central nervous system.

Current neuropharmacology 20100901

Tryptophan metabolite 3-hydroxyanthranilic acid selectively induces activated T cell death via intracellular GSH depletion.

Immunology letters 20100816

Indoleamine 2,3-dioxigenase (IDO) is critical for host resistance against Trypanosoma cruzi.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100801

The possible role of the kynurenine pathway in adolescent depression with melancholic features.

Journal of child psychology and psychiatry, and allied disciplines 20100801

Insights into therapy: tryptophan oxidation and HIV infection.

Science translational medicine 20100519

Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

Science translational medicine 20100519

Production of novel antioxidative phenolic amides through heterologous expression of the plant's chlorogenic acid biosynthesis genes in yeast.

Metabolic engineering 20100501

Promoter hypermethylation of CIDEA, HAAO and RXFP3 associated with microsatellite instability in endometrial carcinomas.

Gynecologic oncology 20100501

The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study.

Progress in neuro-psychopharmacology & biological psychiatry 20100201

Characterization of the anthranilate degradation pathway in Geobacillus thermodenitrificans NG80-2.

Microbiology (Reading, England) 20100201

Effect of dipterinyl calcium pentahydrate on hepatitis B virus replication in transgenic mice.

Journal of translational medicine 20100101

Bench-to-bedside review: bacterial pneumonia with influenza - pathogenesis and clinical implications.

Critical care (London, England) 20100101

Attention-deficit hyperactivity disorder (ADHD) and glial integrity: an exploration of associations of cytokines and kynurenine metabolites with symptoms and attention.

Behavioral and brain functions : BBF 20100101

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease.

Redox report : communications in free radical research 20100101

Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease.

International journal of Alzheimer's disease 20100101

Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease.

International journal of Alzheimer's disease 20100101

On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio.

International journal of tryptophan research : IJTR 20100101

IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease.

International journal of tryptophan research : IJTR 20100101

Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder.

International journal of tryptophan research : IJTR 20100101

Kynurenine Pathway Metabolism is Involved in the Maintenance of the Intracellular NAD Concentration in Human Primary Astrocytes.

International journal of tryptophan research : IJTR 20100101

Rapid Isocratic Liquid Chromatographic Separation and Quantification of Tryptophan and Six kynurenine Metabolites in Biological Samples with Ultraviolet and Fluorimetric Detection.

International journal of tryptophan research : IJTR 20100101

Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase.

Biopolymers 20091201

Initial characterization of a recombinant kynureninase from Trypanosoma cruzi identified from an EST database.

Gene 20091201

Identification of candidate epigenetic biomarkers for ovarian cancer detection.

Oncology reports 20091001

Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM 20090501

Kynurenine pathway inhibition reduces central nervous system inflammation in a model of human African trypanosomiasis.

Brain : a journal of neurology 20090501

5-Hydroxyanthranilic acid, a tryptophan metabolite, generates oxidative stress and neuronal death via p38 activation in cultured cerebellar granule neurones.

Neurotoxicity research 20090501

Suppression of T-cell response and prolongation of allograft survival in a rat model by tryptophan catabolites.

European journal of pharmacology 20090315

Targeting the progression of Parkinson's disease.

Current neuropharmacology 20090301

Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase.

Genes to cells : devoted to molecular & cellular mechanisms 20090201

Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity.

Journal of medicinal chemistry 20090122

Anti-infectious activity of tryptophan metabolites in the L-tryptophan-L-kynurenine pathway.

Biological & pharmaceutical bulletin 20090101

Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization.

BMC genomics 20090101

Macrophage antioxidant protection within atherosclerotic plaques.

Frontiers in bioscience (Landmark edition) 20090101

Kynurenine pathway metabolites in humans: disease and healthy States.

International journal of tryptophan research : IJTR 20090101

Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons.

International journal of tryptophan research : IJTR 20090101

The physiological action of picolinic Acid in the human brain.

International journal of tryptophan research : IJTR 20090101

NO scavenging by 3-hydroxyanthranilic acid and 3-hydroxykynurenine: N-nitrosation leads via oxadiazoles to o-quinone diazides.

Nitric oxide : biology and chemistry 20081101

Biosynthesis of diazepinomicin/ECO-4601, a Micromonospora secondary metabolite with a novel ring system.

Journal of natural products 20080901

Metabolic reconstruction of aromatic compounds degradation from the genome of the amazing pollutant-degrading bacterium Cupriavidus necator JMP134.

FEMS microbiology reviews 20080801

Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species.

European journal of pharmacology 20080610

Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder.

Neurochemistry international 20080501

Simultaneous measurement of tryptophan and related compounds by liquid chromatography/electrospray ionization tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase.

Immunology letters 20080415

Effect of 3-hydroxyanthranilic acid in the immunosuppressive molecules indoleamine dioxygenase and HLA-G in macrophages.

Immunology letters 20080415

Iron source preference and regulation of iron uptake in Cryptococcus neoformans.

PLoS pathogens 20080201

Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase.

Journal of cellular biochemistry 20080101

IDO expands human CD4+CD25high regulatory T cells by promoting maturation of LPS-treated dendritic cells.

European journal of immunology 20071101

Altered kynurenine metabolism correlates with infarct volume in stroke.

The European journal of neuroscience 20071001

Nanosensor detection of an immunoregulatory tryptophan influx/kynurenine efflux cycle.

PLoS biology 20071001

The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis.

Rheumatology (Oxford, England) 20070901

Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans.

International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20070701

Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantation.

Plastic and reconstructive surgery 20070601

Crystal structure of Homo sapiens kynureninase.

Biochemistry 20070313

Mechanisms by which acyclovir reduces the oxidative neurotoxicity and biosynthesis of quinolinic acid.

Life sciences 20070213

Kynurenines impair energy metabolism in rat cerebral cortex.

Cellular and molecular neurobiology 20070201

Fe(3+)- and Cu(2+)-reduction by phenol derivatives associated with Azure B degradation in Fenton-like reactions.

Chemosphere 20070101

In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain.

Neurochemistry international 20070101

Degradation of 2-nitrobenzoate by Burkholderia terrae strain KU-15.

Bioscience, biotechnology, and biochemistry 20070101

Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different types of headaches.

American journal of therapeutics 20070101

Mechanisms of copper ion mediated Huntington's disease progression.

PloS one 20070101

Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.

PLoS biology 20061201

Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury.

Neurobiology of disease 20061101

Kynurenine pathway metabolism in patients with osteoporosis after 2 years of drug treatment.

Clinical and experimental pharmacology & physiology 20061101

Acetylsalicylic acid and acetaminophen protect against oxidative neurotoxicity.

Metabolic brain disease 20060901

Tryptophan metabolism in the central nervous system: medical implications.

Expert reviews in molecular medicine 20060831

3-Hydroxyanthranilic acid, one of L-tryptophan metabolites, inhibits monocyte chemoattractant protein-1 secretion and vascular cell adhesion molecule-1 expression via heme oxygenase-1 induction in human umbilical vein endothelial cells.

Atherosclerosis 20060801

Regulatory role of tryptophan degradation pathway in HLA-G expression by human monocyte-derived dendritic cells.

Molecular immunology 20060701

4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury.

Journal of neurotrauma 20060601

Changes in the immune system in depression and dementia: causal or coincidental effects?

Dialogues in clinical neuroscience 20060601

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Crystal structure of 3-hydroxyanthranilic acid 3,4-dioxygenase from Saccharomyces cerevisiae: a special subgroup of the type III extradiol dioxygenases.

Protein science : a publication of the Protein Society 20060401

Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines.

European journal of immunology 20060201

Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits.

Life sciences 20060118

Tryptophan metabolism and oxidative stress in patients with chronic brain injury.

European journal of neurology 20060101

Comparative EST analysis provides insights into the basal aquatic fungus Blastocladiella emersonii.

BMC genomics 20060101

[A short test for potential carcinogenicity of water soluble synthetic polymers].

Biomeditsinskaia khimiia 20060101

Radical scavenging and catalytic activity of metal-phenolic complexes.

The journal of physical chemistry. B 20051222

The effect of age on the enzyme activities of tryptophan metabolism along the kynurenine pathway in rats.

Clinica chimica acta; international journal of clinical chemistry 20051001

Profiling dendritic cell maturation with dedicated microarrays.

Journal of leukocyte biology 20050901

Localisation of indoleamine 2,3-dioxygenase and kynurenine hydroxylase in the human placenta and decidua: implications for role of the kynurenine pathway in pregnancy.

Placenta 20050701

The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate.

Biochemistry 20050531

Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis.

Biochemistry 20050531

Tryptophan metabolism and oxidative stress in patients with Huntington's disease.

Journal of neurochemistry 20050501

Tryptophan metabolites interfere with the Ehrlich reaction used for the measurement of kynurenine.

Analytical biochemistry 20050401

The pyridine ring of NAD is formed by a nonenzymatic pericyclic reaction.

Journal of the American Chemical Society 20050126

Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo.

Transplant international : official journal of the European Society for Organ Transplantation 20050101

Reduced serotonin and 3-hydroxyanthranilic acid levels in serum of cystatin B-deficient mice, a model system for progressive myoclonus epilepsy.

Epilepsia 20050101

Tryptophan metabolism along the kynurenine pathway in diet-induced and genetic hypercholesterolemic rabbits.

Clinica chimica acta; international journal of clinical chemistry 20041201

Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens.

Proceedings of the National Academy of Sciences of the United States of America 20041123

Tryptophan loading induces oxidative stress.

Free radical research 20041101

Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79.

Biochemistry 20041005

Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway.

Toxicological sciences : an official journal of the Society of Toxicology 20041001

3-Hydroxyanthranilic acid, one of metabolites of tryptophan via indoleamine 2,3-dioxygenase pathway, suppresses inducible nitric oxide synthase expression by enhancing heme oxygenase-1 expression.

Biochemical and biophysical research communications 20040806

Identification of novel molecular candidates for fatty liver in the hyperlipidemic mouse model, HcB19.

Journal of lipid research 20040601

Interference of some tryptophan metabolites in the formation of melanin in vitro.

Pigment cell research 20040401

Neurotoxic and neurobehavioral effects of kynurenines in adult insects.

Biochemical and biophysical research communications 20031226

Branching of o-nitrobenzoate degradation pathway in Arthrobacter protophormiae RKJ100: identification of new intermediates.

FEMS microbiology letters 20031212

First evidence of catalytic mediation by phenolic compounds in the laccase-induced oxidation of lignin models.

European journal of biochemistry 20030901

Enzyme activities of tryptophan metabolism along the kynurenine pathway in various species of animals.

Farmaco (Societa chimica italiana : 1989) 20030901

3-Hydroxyanthranilate in Cryptococcus neoformans: a secreted reductant that does not enable wood rot.

Medical mycology 20030801

Purification and inactivation of 3-hydroxyanthranilic acid 3,4-dioxygenase from beef liver.

The international journal of biochemistry & cell biology 20030701

High-performance liquid chromatographic method for the quantification of anthranilic and 3-hydroxyanthranilic acid in rat brain dialysate.

Journal of pharmaceutical and biomedical analysis 20030601

Peripheral distribution of kynurenine metabolites and activity of kynurenine pathway enzymes in renal failure.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030601

Determination of laccase activity in mixed solvents: comparison between two chromogens in a spectrophotometric assay.

Biotechnology and bioengineering 20030520

Kynurenines and the respiratory parameters on rat heart mitochondria.

Life sciences 20030124

Electrochemical and in vitro evaluation of the redox-properties of kynurenine species.

Biochemical and biophysical research communications 20030117

Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase.

BMC biochemistry 20030101

Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface.

Reproductive biology and endocrinology : RB&E 20030101

Kynurenine and neopterin levels in patients with rheumatoid arthritis and osteoporosis during drug treatment.