4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
| Title | Journal |
|---|---|
| The value of integrating pre-clinical data to predict nausea and vomiting risk in humans as illustrated by AZD3514, a novel androgen receptor modulator. | Toxicology and applied pharmacology 20160401 |
| Effects of lisdexamfetamine in a rat model of binge-eating. | Journal of psychopharmacology (Oxford, England) 20151201 |
| Atrazine enhances progesterone production through activation of multiple signaling pathways in FSH-stimulated rat granulosa cells: evidence for premature luteinization. | Biology of reproduction 20141101 |
| Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. | eLife 20140101 |
| Flavanoids induce expression of the suppressor of cytokine signalling 3 (SOCS3) gene and suppress IL-6-activated signal transducer and activator of transcription 3 (STAT3) activation in vascular endothelial cells. | The Biochemical journal 20130901 |
| Quercetin acutely relaxes airway smooth muscle and potentiates β-agonist-induced relaxation via dual phosphodiesterase inhibition of PLCβ and PDE4. | American journal of physiology. Lung cellular and molecular physiology 20130901 |
| Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. | Advances in experimental medicine and biology 20130101 |
| Phosphodiesterase 4-targeted treatments for autoimmune diseases. | BMC medicine 20130101 |
| Role of yessotoxin in calcium and cAMP-crosstalks in primary and K-562 human lymphocytes: the effect is mediated by anchor kinase A mitochondrial proteins. | Journal of cellular biochemistry 20121201 |
| Phosphodiesterases as therapeutic targets for Alzheimer's disease. | ACS chemical neuroscience 20121121 |
| Atrazine acts as an endocrine disrupter by inhibiting cAMP-specific phosphodiesterase-4. | Toxicology and applied pharmacology 20121115 |
| Regio- and enantioselective palladium-catalyzed allylic alkylation of nitromethane with monosubstituted allyl substrates: synthesis of (R)-rolipram and (R)-baclofen. | The Journal of organic chemistry 20121019 |
| Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder. | Biological psychiatry 20121001 |
| Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study. | Urology 20121001 |
| Evidence for global reduction in brain cyclic adenosine monophosphate signaling in depression. | Biological psychiatry 20121001 |
| Phosphodiesterase inhibitor modulation of brain microvascular endothelial cell barrier properties. | Journal of the neurological sciences 20120915 |
| Design, synthesis, and pharmacological evaluation of N-acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. | Journal of medicinal chemistry 20120913 |
| Various phosphodiesterase activities in different regions of the heart alter the cardiac effects of nitric oxide. | Journal of cardiovascular pharmacology 20120901 |
| Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. | Journal of controlled release : official journal of the Controlled Release Society 20120810 |
| Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells. | Journal of cellular and molecular medicine 20120701 |
| Working memory in the aged Ts65Dn mouse, a model for Down syndrome. | Behavioural brain research 20120615 |
| Cyclic AMP dysregulates intestinal epithelial cell restitution through PKA and RhoA. | Inflammatory bowel diseases 20120601 |
| Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle. | The Journal of pharmacology and experimental therapeutics 20120601 |
| Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation. | The Journal of physiology 20120601 |
| Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible. | American journal of physiology. Heart and circulatory physiology 20120515 |
| Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer. | The Prostate 20120515 |
| Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease. | American journal of respiratory cell and molecular biology 20120501 |
| Effects of protein kinase A and G inhibitors on hippocampal cholinergic markers expressions in rolipram- and sildenafil-induced spatial memory improvement. | Pharmacology, biochemistry, and behavior 20120501 |
| Design and synthesis of 4-alkynyl pyrazoles as inhibitors of PDE4: a practical access via Pd/C-Cu catalysis. | Bioorganic & medicinal chemistry letters 20120401 |
| C-C bond formation at C-2 of a quinoline ring: synthesis of 2-(1H-indol-3-yl)quinoline-3-carbonitrile derivatives as a new class of PDE4 inhibitors. | Bioorganic & medicinal chemistry 20120401 |
| 4,4-Dimethyl-2-[3-nitro-2-phenyl-1-(phenyl-sulfan-yl)prop-yl]-4,5-dihydro-1,3-oxazole. | Acta crystallographica. Section E, Structure reports online 20120401 |
| Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice. | Neuropharmacology 20120301 |
| PDE4 inhibition enhances hippocampal synaptic plasticity in vivo and rescues MK801-induced impairment of long-term potentiation and object recognition memory in an animal model of psychosis. | Translational psychiatry 20120301 |
| Phosphodiesterase inhibitors control A172 human glioblastoma cell death through cAMP-mediated activation of protein kinase A and Epac1/Rap1 pathways. | Life sciences 20120227 |
| Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. | Cell 20120203 |
| A re-assessment of a combinatorial treatment involving Schwann cell transplants and elevation of cyclic AMP on recovery of motor function following thoracic spinal cord injury in rats. | Experimental neurology 20120201 |
| Phosphodiesterase 4 inhibition enhances the dopamine D1 receptor/PKA/DARPP-32 signaling cascade in frontal cortex. | Psychopharmacology 20120201 |
| Montmorillonite K-10 mediated green synthesis of cyano pyridines: Their evaluation as potential inhibitors of PDE4. | European journal of medicinal chemistry 20120201 |
| Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ. | PloS one 20120101 |
| Lipidic nanocapsule drug delivery: neuronal protection for cochlear implant optimization. | International journal of nanomedicine 20120101 |
| Vinpocetine inhibits oligodendroglial precursor cell differentiation. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101 |
| The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injury. | PloS one 20120101 |
| Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness. | Journal of medicinal chemistry 20111208 |
| Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2. | Bioorganic & medicinal chemistry letters 20111201 |
| Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. | Psychopharmacology 20111101 |
| Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease. | Human molecular genetics 20111101 |
| Effect of TNF-α production inhibitors on the production of pro-inflammatory cytokines by peripheral blood mononuclear cells from HTLV-1-infected individuals. | Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20111101 |
| NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues. | American journal of physiology. Lung cellular and molecular physiology 20111001 |
| Safety and efficacy of new 3,6-diaryl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine analogs as potential phosphodiesterase-4 inhibitors in NIH-3T3 mouse fibroblastic cells. | Chemical biology & drug design 20110901 |
| Phosphodiesterase-4 inhibition reduces proteolysis and atrogenes expression in rat skeletal muscles. | Muscle & nerve 20110901 |
| Effects of repeated treatment with phosphodiesterase-4 inhibitors on cAMP signaling, hippocampal cell proliferation, and behavior in the forced-swim test. | The Journal of pharmacology and experimental therapeutics 20110801 |
| A combination immunomodulatory treatment promotes neuroprotection and locomotor recovery after contusion SCI. | Experimental neurology 20110701 |
| 2-(2-Fluorobenzamido)benzoate ethyl ester (EFB-1) inhibits superoxide production by human neutrophils and attenuates hemorrhagic shock-induced organ dysfunction in rats. | Free radical biology & medicine 20110615 |
| Partially purified extract and viscolin from Viscum coloratum attenuate airway inflammation and eosinophil infiltration in ovalbumin-sensitized mice. | Journal of ethnopharmacology 20110601 |
| Effect of phoshpodiesterase 4 (PDE4) inhibibtors on eotaxin expression in humen bronchial epithelial cells. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110601 |
| Epac-mediated cAMP-signalling in the mouse model of Rett Syndrome. | Neuropharmacology 20110501 |
| Oxidative stress-induced glucocorticoid resistance is prevented by dual PDE3/PDE4 inhibition in human alveolar macrophages. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20110401 |
| Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation. | The Journal of biological chemistry 20110304 |
| Anti-inflammatory properties of Septilin in lipopolysaccharide activated monocytes and macrophage. | Immunopharmacology and immunotoxicology 20110301 |
| Effect of elevated intracellular cAMP levels on actomyosin contraction in bovine trabecular meshwork cells. | Investigative ophthalmology & visual science 20110301 |
| Asymmetric synthesis of β-substituted γ-lactams via rhodium/diene-catalyzed 1,4-additions: application to the synthesis of (R)-baclofen and (R)-rolipram. | Organic letters 20110218 |
| Soluble adenylyl cyclase mediates bicarbonate-dependent corneal endothelial cell protection. | American journal of physiology. Cell physiology 20110201 |
| Beta-adrenergic stimulation contributes to maintenance of endothelial barrier functions under baseline conditions. | Microcirculation (New York, N.Y. : 1994) 20110201 |
| Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. | Microcirculation (New York, N.Y. : 1994) 20110201 |
| PET of (R)-11C-rolipram binding to phosphodiesterase-4 is reproducible and sensitive to increased norepinephrine in the rat heart. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110201 |
| Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110105 |
| Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28. | PloS one 20110101 |
| Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. | Journal of biomedical science 20110101 |
| Tissue plasminogen activator expression and barrier properties of human brain microvascular endothelial cells. | Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101 |
| PET measurements of cAMP-mediated phosphodiesterase-4 with (R)-[11C]rolipram. | Current radiopharmaceuticals 20110101 |
| Macro- and microrheological parameters of blood in patients with cerebral and peripheral atherosclerosis: the molecular change mechanisms after pentoxifylline treatment. | Clinical hemorheology and microcirculation 20110101 |
| Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro. | Life sciences 20101218 |
| Interactive inhibitory effects of formoterol and montelukast on activated human neutrophils. | The European respiratory journal 20101201 |
| Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. | Urology 20101201 |
| Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C. | The Biochemical journal 20101115 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Control of melanocyte differentiation by a MITF-PDE4D3 homeostatic circuit. | Genes & development 20101015 |
| Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors. | Journal of medicinal chemistry 20101014 |
| Enhanced expression of ATP-binding cassette transporter A1 in non-rafts decreases the sensitivity of vascular endothelial cells to Shiga toxin. | Microbial pathogenesis 20101001 |
| p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. | Cellular signalling 20101001 |
| Genistein, a competitive PDE1-4 inhibitor, may bind on high-affinity rolipram binding sites of brain cell membranes and then induce gastrointestinal adverse effects. | European journal of pharmacology 20100915 |
| Bronchodilatory effect of Acorus calamus (Linn.) is mediated through multiple pathways. | Journal of ethnopharmacology 20100915 |
| Methylxanthine reversal of opioid-evoked inspiratory depression via phosphodiesterase-4 blockade. | Respiratory physiology & neurobiology 20100731 |
| Function of cardiac beta1- and beta2-adrenoceptors of newborn piglets: role of phosphodiesterases PDE3 and PDE4. | European journal of pharmacology 20100725 |
| Rolipram and SP600125 suppress the early increase in PTP1B expression during cerulein-induced pancreatitis in rats. | Pancreas 20100701 |
| Effect of cyclic AMP-elevating agents on airway ciliary beat frequency in central and lateral airways in rat precision-cut lung slices. | European journal of pharmacology 20100610 |
| Antidepressants, but not antipsychotics, modulate GR function in human whole blood: an insight into molecular mechanisms. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100601 |
| Perivascular fluid cuffs decrease lung compliance by increasing tissue resistance. | Critical care medicine 20100601 |
| The flavonoid dioclein reduces the production of pro-inflammatory mediators in vitro by inhibiting PDE4 activity and scavenging reactive oxygen species. | European journal of pharmacology 20100510 |
| Type 4 phosphodiesterase plays different integrating roles in different cellular domains in pyramidal cortical neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100428 |
| Prostanoid TP receptor-mediated impairment of cyclic AMP-dependent vasorelaxation is reversed by phosphodiesterase inhibitors. | European journal of pharmacology 20100425 |
| Action of a Novel PDE4 inhibitor ZL-n-91 on lipopolysaccharide-induced acute lung injury. | International immunopharmacology 20100401 |
| Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity. | Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20100401 |
| Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. | Bioorganic & medicinal chemistry letters 20100401 |
| The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner. | Immunology 20100301 |
| Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disorders. | Alcoholism, clinical and experimental research 20100301 |
| Luteolin, a non-selective competitive inhibitor of phosphodiesterases 1-5, displaced [3H]-rolipram from high-affinity rolipram binding sites and reversed xylazine/ketamine-induced anesthesia. | European journal of pharmacology 20100210 |
| Relationship between phosphodiesterase type 4 inhibition and anti-inflammatory activity of CI-1044 in rat airways. | Fundamental & clinical pharmacology 20100201 |
| Effects of cAMP-dependent protein kinase activator and inhibitor on in vivo rolipram binding to phosphodiesterase 4 in conscious rats. | Synapse (New York, N.Y.) 20100201 |
| A new model of the disrupted latent inhibition in C57BL/6J mice after bupropion treatment. | Psychopharmacology 20100201 |
| Synaptic adaptations of CA1 pyramidal neurons induced by a highly effective combinational antidepressant therapy. | Biological psychiatry 20100115 |
| The type IV phosphodiesterase inhibitor rolipram disturbs expression and extinction of conditioned fear in mice. | Neuropharmacology 20100101 |
| Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20100101 |
| Various emetogens increase the secretion of salivary amylase in rats: a potential model in emesis research. | Journal of pharmacological sciences 20100101 |
| Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. | Arthritis research & therapy 20100101 |
| Elevated cAMP opposes (TNF-alpha)-induced loss in the barrier integrity of corneal endothelium. | Molecular vision 20100101 |
| The selective inhibition of type IV phosphodiesterase attenuates the severity of the acute pancreatitis in rats. | Digestive diseases and sciences 20091201 |
| Evidence that corticotropin-releasing hormone modulates myometrial contractility during human pregnancy. | Endocrinology 20091201 |
| Theophylline inhibits the differentiation of human monocyte into dendritic cell potentially via adenosine receptor antagonism. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20091201 |
| Phosphodiesterase isozymes involved in regulating acid secretion in the isolated mouse stomach. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20091201 |
| Sleep deprivation impairs cAMP signalling in the hippocampus. | Nature 20091022 |
| Effects of rolipram and diazepam on the adaptive changes induced by morphine withdrawal in the hypothalamic paraventricular nucleus. | European journal of pharmacology 20091012 |
| Activity-based therapies to promote forelimb use after a cervical spinal cord injury. | Journal of neurotrauma 20091001 |
| The involvement of type IV phosphodiesterases in cocaine-induced sensitization and subsequent pERK expression in the mouse nucleus accumbens. | Psychopharmacology 20091001 |
| Accelerating axon growth to overcome limitations in functional recovery after peripheral nerve injury. | Neurosurgery 20091001 |
| Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown. | Journal of cellular physiology 20090901 |
| The identification of a novel phosphodiesterase 4 inhibitor, 1-ethyl-5-{5-[(4-methyl-1-piperazinyl)methyl]-1,3,4-oxadiazol-2-yl}-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (EPPA-1), with improved therapeutic index using pica feeding in rats as a measure of emetogenicity. | The Journal of pharmacology and experimental therapeutics 20090901 |
| Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation. | Peptides 20090901 |
| Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats. | Respirology (Carlton, Vic.) 20090901 |
| In vitro activity of 20 agents in different prognostic subgroups of chronic lymphocytic leukemia--rolipram and prednisolone active in cells from patients with poor prognosis. | European journal of haematology 20090701 |
| Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. | Bioorganic & medicinal chemistry letters 20090701 |
| Amelioration of pulmonary dysfunction and neutrophilic inflammation by PPAR gamma agonist in LPS-exposed guinea pigs. | Pulmonary pharmacology & therapeutics 20090601 |
| PDE4 inhibitors roflumilast and rolipram augment PGE2 inhibition of TGF-{beta}1-stimulated fibroblasts. | American journal of physiology. Lung cellular and molecular physiology 20090601 |
| The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. | British journal of pharmacology 20090601 |
| Involvement of phosphodiesterase 4 in beta-adrenoceptor agonist-induced amylase release in parotid acinar cells. | Journal of oral science 20090601 |
| Effect of phosphodiesterase antagonists on glucocorticoid mediated growth inhibition in murine skin cell lines. | European journal of pharmacology 20090521 |
| Regulation of AMP-activated protein kinase by cAMP in adipocytes: roles for phosphodiesterases, protein kinase B, protein kinase A, Epac and lipolysis. | Cellular signalling 20090501 |
| Uncovering multiple molecular targets for caffeine using a drug target validation strategy combining A 2A receptor knockout mice with microarray profiling. | Physiological genomics 20090501 |
| Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. | Bioorganic & medicinal chemistry letters 20090415 |
| Phosphodiesterases PDE3 and PDE4 jointly control the inotropic effects but not chronotropic effects of (-)-CGP12177 despite PDE4-evoked sinoatrial bradycardia in rat atrium. | Naunyn-Schmiedeberg's archives of pharmacology 20090401 |
| Developmental etiology for neuroanatomical and cognitive deficits in mice overexpressing Galphas, a G-protein subunit genetically linked to schizophrenia. | Molecular psychiatry 20090401 |
| The type 4 phosphodiesterase inhibitors rolipram and YM976 facilitate recall of the weak version of the passive avoidance task in the day-old chick. | Pharmacology, biochemistry, and behavior 20090401 |
| Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils. | Bioorganic & medicinal chemistry letters 20090401 |
| Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury. | Experimental neurology 20090401 |
| Systemic administration of rolipram increases medullary and spinal cAMP and activates a latent respiratory motor pathway after high cervical spinal cord injury. | The journal of spinal cord medicine 20090401 |
| Dual inhibitors of phosphodiesterase-4 and serotonin reuptake. | Journal of medicinal chemistry 20090326 |
| PDE type-4 inhibition increases L-type Ca(2+) currents, action potential firing, and quantal size of exocytosis in mouse chromaffin cells. | Pflugers Archiv : European journal of physiology 20090301 |
| Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington's disease. | The European journal of neuroscience 20090301 |
| Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. | Canadian journal of physiology and pharmacology 20090301 |
| ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes. | Immunology letters 20090221 |
| Potential of the rat model of conditioned gaping to detect nausea produced by rolipram, a phosphodiesterase-4 (PDE4) inhibitor. | Pharmacology, biochemistry, and behavior 20090201 |
| Utero-relaxant effect of PDE4-selective inhibitor alone and in simultaneous administration with beta2-mimetic on oxytocin-induced contractions in pregnant myometrium. | The journal of obstetrics and gynaecology research 20090201 |
| Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis. | Glia 20090115 |
| Rolipram, a specific type-4 phosphodiesterase inhibitor, inhibits cyclophosphamide-induced haemorrhagic cystitis in rats. | BJU international 20090101 |
| Increased particulate phosphodiesterase 4 in the prefrontal cortex supports 5-HT4 receptor-induced improvement of object recognition memory in the rat. | Psychopharmacology 20090101 |
| Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte. | International immunopharmacology 20090101 |
| Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart. | British journal of pharmacology 20090101 |
| Ontogenic changes of the control by phosphodiesterase-3 and -4 of 5-HT responses in porcine heart and relevance to human atrial 5-HT(4) receptors. | British journal of pharmacology 20090101 |
| Pharmacology of a novel, orally active PDE4 inhibitor. | Pharmacology 20090101 |
| Design, synthesis, and structure-activity relationship, molecular modeling, and NMR studies of a series of phenyl alkyl ketones as highly potent and selective phosphodiesterase-4 inhibitors. | Journal of medicinal chemistry 20081225 |
| Evidence that a protein kinase A substrate, small heat-shock protein 20, modulates myometrial relaxation in human pregnancy. | Endocrinology 20081201 |
| Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. | Experimental neurology 20081201 |
| Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. | Clinical cancer research : an official journal of the American Association for Cancer Research 20081201 |
| mc1r Pathway regulation of zebrafish melanosome dispersion. | Zebrafish 20081201 |
| Neuroenhancement: status quo and perspectives. | European archives of psychiatry and clinical neuroscience 20081101 |
| Inhibitory effects of quercetin derivatives on phosphodiesterase isozymes and high-affinity [(3) H]-rolipram binding in guinea pig tissues. | Investigational new drugs 20081001 |
| Prophylactic effect of irsogladine maleate against indomethacin-induced small intestinal lesions in rats. | Digestive diseases and sciences 20081001 |
| Preventive effect of rolipram, a phosphodiesterase 4 enzyme inhibitor, on oxidative renal injury in acute ascending pyelonephritis model in rats. | Urology 20081001 |
| Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity. | Investigative ophthalmology & visual science 20081001 |
| Optimization and validation of a reporter gene assay for screening of phosphodiesterase inhibitors in a high throughput system. | Biotechnology journal 20081001 |
| Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. | Journal of medicinal chemistry 20080925 |
| Curative effects of phosphodiesterase 4 inhibitors cilomilast, roflumilast, and rolipram in dermatitis mouse model. | Journal of dermatological science 20080901 |
| Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. | The Journal of biological chemistry 20080815 |
| Cyclic-AMP-dependent proliferation of a human osteoblast cell line (HOS cells) induced by hydroxyapatite: effect of exogenous nitric oxide. | Acta bio-medica : Atenei Parmensis 20080801 |
| Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity. | Journal of medicinal chemistry 20080724 |
| Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors. | Bioorganic & medicinal chemistry letters 20080715 |
| Inhibition of protein kinase A improves effector function of monocytes from HIV-infected patients. | AIDS research and human retroviruses 20080701 |
| Prolonged heterologous beta2-adrenoceptor desensitization promotes proasthmatic airway smooth muscle function via PKA/ERK1/2-mediated phosphodiesterase-4 induction. | American journal of physiology. Lung cellular and molecular physiology 20080601 |
| cAMP induced Rac 1-mediated cytoskeletal reorganization in microvascular endothelium. | Histochemistry and cell biology 20080601 |
| Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease. | Neurobiology of disease 20080601 |
| Effect of phosphodiesterase type 4 inhibitor rolipram on cyclophosphamide-induced cystitis in rats. | European journal of pharmacology 20080531 |
| Mechanisms of the relaxant effect of vardenafil in rat penile arteries. | European journal of pharmacology 20080531 |
| Epi-cinchona based thiourea organocatalyst family as an efficient asymmetric Michael addition promoter: enantioselective conjugate addition of nitroalkanes to chalcones and alpha,beta-unsaturated N-acylpyrroles. | The Journal of organic chemistry 20080502 |
| Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H-benzimidazoles. | European journal of medicinal chemistry 20080501 |
| PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways. | Cellular signalling 20080501 |
| Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca(2+) responses in endothelial cells. | British journal of pharmacology 20080501 |
| Attenuation of MPTP neurotoxicity by rolipram, a specific inhibitor of phosphodiesterase IV. | Experimental neurology 20080501 |
| Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine. | Organic letters 20080403 |
| Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. | Experimental neurology 20080401 |
| Changes in the expression and dynamics of SHP-1 and SHP-2 during cerulein-induced acute pancreatitis in rats. | Biochimica et biophysica acta 20080401 |
| PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. | European journal of pharmacology 20080317 |
| Rhodanine derivatives as novel inhibitors of PDE4. | Bioorganic & medicinal chemistry letters 20080315 |
| Selective PDE inhibitors rolipram and sildenafil improve object retrieval performance in adult cynomolgus macaques. | Psychopharmacology 20080301 |
| Phosphodiesterase-4 inhibition attenuates pulmonary inflammation in neonatal lung injury. | The European respiratory journal 20080301 |
| Epac/Rap1 pathway regulates microvascular hyperpermeability induced by PAF in rat mesentery. | American journal of physiology. Heart and circulatory physiology 20080301 |
| Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue. | Urology 20080301 |
| Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors. | Bioorganic & medicinal chemistry letters 20080215 |
| Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (-)-adrenaline mediated through mouse cardiac beta(1)-adrenoceptors. | British journal of pharmacology 20080201 |
| Phosphodiesterase inhibitors--are they potential neuroleptic drugs? | Behavioural brain research 20080125 |
| Inhibition of phosphodiesterase type 4 decreases stress-induced defecation in rats and mice. | Pharmacology 20080101 |
| The role of VASP in regulation of cAMP- and Rac 1-mediated endothelial barrier stabilization. | American journal of physiology. Cell physiology 20080101 |
| Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol. | Pulmonary pharmacology & therapeutics 20080101 |
| Protein kinase C- and reactive oxygen species-dependent stimulation of intracellular cAMP in human eosinophils. The role of extracellular signal-regulated protein kinases. | Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101 |
| Effects of phosphodiesterase 4 inhibition on alveolarization and hyperoxia toxicity in newborn rats. | PloS one 20080101 |
| Phosphodiesterase 4 inhibition but not beta-adrenergic stimulation suppresses tumor necrosis factor-alpha release in peripheral blood mononuclear cells in septic shock. | Critical care (London, England) 20080101 |
| Microtubule motors regulate ISOC activation necessary to increase endothelial cell permeability. | The Journal of biological chemistry 20071130 |
| Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain. | European journal of pharmacology 20071114 |
| Rh-catalyzed asymmetric hydrogenation of gamma-phthalimido-substituted alpha,beta-unsaturated carboxylic acid esters: an efficient enantioselective synthesis of beta-aryl-gamma-amino acids. | Organic letters 20071108 |
| Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat. | Journal of cardiovascular pharmacology 20071001 |
| Phosphodiesterase 4 inhibitors, rolipram and diazepam block the adaptive changes observed during morphine withdrawal in the heart. | European journal of pharmacology 20070910 |
| [Recent progress in basic research concerning the management of benign prostatic hyperplasia]. | Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20070901 |
| High-performance liquid chromatographic separation of rolipram, bupivacaine and omeprazole using a tartardiamide-based stationary phase influence of flow rate and temperature on the enantioseparation. | Journal of chromatography. A 20070824 |
| Phosphodiesterase 4 inhibitors augment levels of glucocorticoid receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20070815 |
| PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). | The Journal of pharmacology and experimental therapeutics 20070801 |
| The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. | British journal of pharmacology 20070801 |
| Effect of sildenafil and rolipram on adrenergic responses in isolated human and monkey corpus cavernosum. | European urology 20070701 |
| Functional responses of isolated human seminal vesicle tissue to selective phosphodiesterase inhibitors. | Urology 20070701 |
| The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat. | Psychopharmacology 20070601 |
| Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme. | Psychopharmacology 20070601 |
| Effects of stimulation of adenosine A2A receptors on lipopolysaccharide-induced production of reactive oxygen species by equine neutrophils. | American journal of veterinary research 20070601 |
| Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. | Cancer research 20070601 |
| Synthesis of pyrrolo[2,3-d]pyridazinones as potent, subtype selective PDE4 inhibitors. | Journal of enzyme inhibition and medicinal chemistry 20070601 |
| Corticosteroids and beta2 agonists differentially regulate rhinovirus-induced interleukin-6 via distinct Cis-acting elements. | The Journal of biological chemistry 20070525 |
| Various effects of antidepressant drugs on bone microarchitectecture, mechanical properties and bone remodeling. | Toxicology and applied pharmacology 20070515 |
| The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia. | Stroke 20070501 |
| A reporter gene assay for screening of PDE4 subtype selective inhibitors. | Biochemical and biophysical research communications 20070427 |
| Elevated cAMP levels reverse Brucella melitensis-induced lipid peroxidation and stimulate IL-10 transcription in rats. | Research in veterinary science 20070401 |
| Alterations in proteoglycan synthesis selectively impair FSH-induced particulate cAMP-phosphodiesterase 4 (PDE4) activation in immature rat Sertoli cells. | Biochimica et biophysica acta 20070401 |
| The effects of both noradrenaline and CGP12177, mediated through human beta1 -adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells. | Naunyn-Schmiedeberg's archives of pharmacology 20070401 |
| Rolipram, a phosphodiesterase 4 inhibitor, suppresses PGE2-induced osteoclast formation by lowering osteoclast progenitor cell viability. | Archives of pharmacal research 20070401 |
| Alpha1-antitrypsin, old dog, new tricks. Alpha1-antitrypsin exerts in vitro anti-inflammatory activity in human monocytes by elevating cAMP. | The Journal of biological chemistry 20070323 |
| Metalloelastase (MMP-12) induced inflammatory response in mice airways: effects of dexamethasone, rolipram and marimastat. | European journal of pharmacology 20070315 |
| Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors. | European journal of pharmacology 20070308 |
| Relaxation of phasic contractile activity of human detrusor strips by cyclic nucleotide phosphodiesterase type 4 inhibition. | European urology 20070301 |
| Beneficial effects of rolipram in a quinolinic acid model of striatal excitotoxicity. | Neurobiology of disease 20070201 |
| SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase. | Journal of medicinal chemistry 20070125 |
| PDE4 inhibition prevents preterm delivery induced by an intrauterine inflammation. | Journal of immunology (Baltimore, Md. : 1950) 20070115 |
| Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. | Neuroscience 20070105 |
| Regulation of luteinizing hormone receptor mRNA expression by a specific RNA binding protein in the ovary. | Molecular and cellular endocrinology 20070102 |
| Phosphodiesterase (PDE) 7 in inflammatory cells from patients with asthma and COPD. | Pulmonary pharmacology & therapeutics 20070101 |
| Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells. | American journal of physiology. Cell physiology 20070101 |
| Preclinical assessment of curcumin as a potential therapy for B-CLL. | American journal of hematology 20070101 |
| Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. | Journal of the American Society of Nephrology : JASN 20070101 |
| Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity. | Journal of applied toxicology : JAT 20070101 |
| In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. | Nuclear medicine and biology 20070101 |
| Antagonism of IL-4 signaling by a phosphodiesterase-4 inhibitor, rolipram, in human T cells. | International archives of allergy and immunology 20070101 |
| Role of protein kinase C in substance P-induced synaptic depression in the nucleus accumbens in vitro. | Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20070101 |
| Difference in preventive effects between the phosphodiesterase iv inhibitor rolipram and anti-arthritic drugs on antigen-induced arthritis in mice. | Immunological investigations 20070101 |
| Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats. | Journal of musculoskeletal & neuronal interactions 20070101 |
| Hormonal regulation of the contractile vacuole in Amoeba proteus: the role of cyclic nucleotide phosphodiesterases. | Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101 |
| The role of IFN-gamma in regulation of IFN-gamma-inducible protein 10 (IP-10) expression in lung epithelial cell and peripheral blood mononuclear cell co-cultures. | Respiratory research 20070101 |
| Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through beta(2)-adrenoceptors than the effects of (-)-noradrenaline through beta (1)-adrenoceptors in human atrial myocardium. | Naunyn-Schmiedeberg's archives of pharmacology 20061201 |
| High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20061115 |
| Cyclic AMP-mediated regulation of the resting membrane potential in myelin-forming oligodendrocytes in the isolated intact rat optic nerve. | Experimental neurology 20061101 |
| Delayed Nogo receptor therapy improves recovery from spinal cord contusion. | Annals of neurology 20061101 |
| Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. | Molecular and cellular neurosciences 20061101 |
| Modulation of melatonin receptors and G-protein function by microtubules. | Journal of pineal research 20061101 |
| Phosphodiesterase 4 inhibitors modulate beta2-adrenoceptor agonist-induced human airway hyperresponsiveness. | Life sciences 20061012 |
| Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds. | Behavioural brain research 20061002 |
| Synergistic effects of cAMP-dependent signalling pathways and IL-1 on IL-6 production by H19-7/IGF-IR neuronal cells. | Cellular signalling 20061001 |
| Salbutamol inhibits trypsin-mediated production of CXCL8 by keratinocytes. | Cytokine 20061001 |
| Neuronal and smooth muscle receptors involved in the PACAP- and VIP-induced relaxations of the pig urinary bladder neck. | British journal of pharmacology 20060901 |
| Analysis of change patterns of microcomputed tomography 3-dimensional bone parameters as a high-throughput tool to evaluate antiosteoporotic effects of agents at an early stage of ovariectomy-induced osteoporosis in mice. | Investigative radiology 20060901 |
| Effects of the phosphodiestrase-4 inhibitor rolipram on lung resistance and inflammatory reaction in experimental asthma. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060901 |
| Lack of cyclic AMP-specific phosphodiesterase 4 activation during naloxone-precipitated morphine withdrawal in rats. | Neuroscience letters 20060814 |
| Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. | FEBS letters 20060724 |
| Specific type IV phosphodiesterase inhibitor ameliorates cerulein-induced pancreatitis in rats. | Biochemical and biophysical research communications 20060721 |
| Local anti-inflammatory effect and behavioral studies on new PDE4 inhibitors. | Life sciences 20060717 |
| Hydraulic conductance of pulmonary microvascular and macrovascular endothelial cell monolayers. | American journal of physiology. Lung cellular and molecular physiology 20060701 |
| Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram. | Brain research 20060622 |
| Increasing synaptic noradrenaline, serotonin and histamine enhances in vivo binding of phosphodiesterase-4 inhibitor (R)-[11C]rolipram in rat brain, lung and heart. | Life sciences 20060620 |
| Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats. | Psychopharmacology 20060601 |
| ANP-mediated cGMP signaling and phosphodiesterase inhibition in the rat cervical spinal cord. | Journal of chemical neuroanatomy 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Activation of the adenylyl cyclase/protein kinase A pathway facilitates neural release of beta-nicotinamide adenine dinucleotide in canine mesenteric artery. | European journal of pharmacology 20060424 |
| Nitric oxide induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells. | American journal of physiology. Lung cellular and molecular physiology 20060401 |
| Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action. | Neurobiology of learning and memory 20060301 |
| Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes. | The Biochemical journal 20060301 |
| Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells. | Experimental biology and medicine (Maywood, N.J.) 20060301 |
| Effect of orally administered rolipram, a phosphodiesterase 4 inhibitor, on a mouse model of the dermatitis caused by 2,4,6-trinitro-1-chlorobenzene (TNCB)-repeated application. | European journal of pharmacology 20060217 |
| Mechanisms of rolipram-induced increase in the incidence of mammary adenocarcinoma: histopathological study of a 104-week oral carcinogenicity study in female Sprague-Dawley rats. | Archives of toxicology 20060201 |
| Selective inhibition of phosphodiesterase-4 ameliorates chronic colitis and prevents intestinal fibrosis. | The Journal of pharmacology and experimental therapeutics 20060201 |
| Multiple signalling pathways involved in beta2-adrenoceptor-mediated glucose uptake in rat skeletal muscle cells. | British journal of pharmacology 20060201 |
| Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation. | The Journal of biological chemistry 20060113 |
| TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi. | Molecular and biochemical parasitology 20060101 |
| An investigation into the effect of the type IV phosphodiesterase inhibitor rolipram in the modulation of glutamate release from rat prefrontocortical nerve terminals. | Synapse (New York, N.Y.) 20060101 |
| Inhibition of airway hyperresponsiveness and pulmonary inflammation by roflumilast and other PDE4 inhibitors. | Pulmonary pharmacology & therapeutics 20060101 |
| Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle. | British journal of pharmacology 20060101 |
| Phosphodiesterase 4 inhibitors for the treatment of asthma and COPD. | Current medicinal chemistry 20060101 |
| [Effect of phosphodiestrase 4 inhibitor (rolipram) on experimental allergic asthma-guinea pig model]. | Pneumonologia i alergologia polska 20060101 |
| Mitogen-activated protein kinase-mediated reinforcement of hippocampal early long-term depression by the type IV-specific phosphodiesterase inhibitor rolipram and its effect on synaptic tagging. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051116 |
| Decreased endocannabinoid levels in the brain and beneficial effects of agents activating cannabinoid and/or vanilloid receptors in a rat model of multiple sclerosis. | Neurobiology of disease 20051101 |
| Interaction between the antidepressant-like behavioral effects of beta adrenergic agonists and the cyclic AMP PDE inhibitor rolipram in rats. | Psychopharmacology 20051001 |
| The pivotal role of cytokines in muscle wasting during cancer. | The international journal of biochemistry & cell biology 20051001 |
| Pharmacological studies on mechanisms of aminophylline-induced seizures in rats. | Indian journal of experimental biology 20051001 |
| Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050928 |
| An Aplysia type 4 phosphodiesterase homolog localizes at the presynaptic terminals of Aplysia neuron and regulates synaptic facilitation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050928 |
| In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region. | Cellular signalling 20050901 |
| Mammalian sperm phosphodiesterases and their involvement in receptor-mediated cell signaling important for capacitation. | Molecular reproduction and development 20050801 |
| Effects of rolipram on induction of action potential bursts in central snail neurons. | Experimental neurology 20050801 |
| Cyclic nucleotide second messengers (cAMP and cGMP) play a central role in signal transduction and regulation of mesenteric postcapillary fluid leak. | The Journal of trauma 20050801 |
| [Evaluation methods for the discriminative stimulus and possible mechanisms of discriminative stimulus effects of methamphetamine in the rat]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20050701 |
| Type 4 phosphodiesterase inhibition impairs detection of low odor concentrations in mice. | Behavioural brain research 20050620 |
| Evidence for a role of phosphodiesterase 4 in lipopolysaccharide-stimulated prostaglandin E2 production and matrix metalloproteinase-9 activity in human amniochorionic membranes. | Journal of immunology (Baltimore, Md. : 1950) 20050615 |
| Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system. | Biochemistry 20050614 |
| Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates aspirin-induced gastric mucosal injury in rats. | Digestive diseases and sciences 20050601 |
| Inotropic responses to phosphodiesterase inhibitors in cardiac hypertrophy in rats. | European journal of pharmacology 20050509 |
| Essential role of a Ca2+-selective, store-operated current (ISOC) in endothelial cell permeability: determinants of the vascular leak site. | Circulation research 20050429 |
| Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium. | American journal of physiology. Heart and circulatory physiology 20050401 |
| Airway function and reactivity, leukocyte influx and nitric oxide after inoculation with parainfluenza-3 virus: effects of dexamethasone or rolipram. | International immunopharmacology 20050401 |
| Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships. | Bioorganic & medicinal chemistry letters 20050401 |
| Rolipram attenuates MK-801-induced deficits in latent inhibition. | Behavioral neuroscience 20050401 |
| Inhibition of mast cell histamine release by specific phosphodiesterase inhibitors. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050401 |
| Phosphodiesterase 4D forms a cAMP diffusion barrier at the apical membrane of the airway epithelium. | The Journal of biological chemistry 20050304 |
| Cyclic nucleotide phosphodiesterases and their role in immunomodulatory responses: advances in the development of specific phosphodiesterase inhibitors. | Medicinal research reviews 20050301 |
| Rolipram, a phosphodiesterase 4 inhibitor, stimulates inducible cAMP early repressor expression in osteoblasts. | Yonsei medical journal 20050227 |
| 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors. | Journal of medicinal chemistry 20050224 |
| Synthesis of 4-aryl-2-pyrrolidones and beta-aryl-gamma-amino-butyric acid (GABA) analogues by Heck arylation of 3-pyrrolines with arenediazonium tetrafluoroborates. Synthesis of (+/-)-rolipram on a multigram scale and chromatographic resolution by semipreparative chiral simulated moving bed chromatography. | The Journal of organic chemistry 20050204 |
| Effect of rolipram on relative 14C-deoxyglucose uptake in inflammatory lesions and skeletal muscle. | European journal of nuclear medicine and molecular imaging 20050201 |
| Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation. | Biochemical pharmacology 20050201 |
| A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells. | Journal of immunology (Baltimore, Md. : 1950) 20050115 |
| The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients. | Pulmonary pharmacology & therapeutics 20050101 |
| Specific type IV phosphodiesterase inhibitor ameliorates thioacetamide-induced liver injury in rats. | Journal of gastroenterology and hepatology 20050101 |
| Rolipram, salbutamol and prostaglandin E2 suppress TNFalpha release from human monocytes by activating Type II cAMP-dependent protein kinase. | Pulmonary pharmacology & therapeutics 20050101 |
| A2A adenosine receptor agonist and PDE4 inhibition delays inflammation but fails to reduce injury in experimental obstructive nephropathy. | Nephron. Experimental nephrology 20050101 |
| Crystallization of cyclic nucleotide phosphodiesterases. | Methods in molecular biology (Clifton, N.J.) 20050101 |
| Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. | Respiratory research 20050101 |
| Potentiation and prolongation of long-term odor memory in neonate rats using a phosphodiesterase inhibitor. | Neuroscience 20050101 |
| An interventional approach to block brain damage caused by Shiga toxin-producing Escherichia coli infection, by use of a combination of phosphodiesterase inhibitors. | The Journal of infectious diseases 20041215 |
| Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8+ T-lymphocytes. | Molecular pharmacology 20041201 |
| Effect of phosphodiesterase 4 inhibitors on NFAT-dependent cyclooxygenase-2 expression in human T lymphocytes. | Cellular signalling 20041201 |
| Chlamydophila pneumoniae induces p44/p42 mitogen-activated protein kinase activation in human fibroblasts through Toll-like receptor 4. | Journal of medical microbiology 20041201 |
| Synthesis and potential anti-inflammatory activity of some tetrahydrophthalazinones. | Journal of enzyme inhibition and medicinal chemistry 20041201 |
| Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils. | Life sciences 20041119 |
| The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3',5'-monophosphate pathway in various cell types. | Endocrinology 20041101 |
| cAMP response element-binding protein activation in ligation preconditioning in neonatal brain. | Annals of neurology 20041101 |
| Comparision of the inotropic effects of levosimendan, rolipram, and dobutamine on human atrial trabeculae. | Journal of cardiovascular pharmacology 20041101 |
| Persistent accumulation of calcium/calmodulin-dependent protein kinase II in dendritic spines after induction of NMDA receptor-dependent chemical long-term potentiation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041020 |
| Endothelins induce ETB receptor-mediated mechanical hypernociception in rat hindpaw: roles of cAMP and protein kinase C. | European journal of pharmacology 20041006 |
| Effect of specific phosphodiesterase isoenzyme inhibitors during in vitro maturation of bovine oocytes on meiotic and developmental capacity. | Biology of reproduction 20041001 |
| Altered activities of cyclic nucleotide phosphodiesterases and soluble guanylyl cyclase in cultured RFL-6 cells. | The international journal of biochemistry & cell biology 20041001 |
| Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors. | Bioorganic & medicinal chemistry 20041001 |
| Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium. | Naunyn-Schmiedeberg's archives of pharmacology 20041001 |
| The induction of cyclic nucleotide phosphodiesterase 4 gene (PDE4D) impairs memory in a water maze task. | Behavioural brain research 20040923 |
| Effects of rolipram, a phosphodiesterase 4 inhibitor, in combination with imipramine on depressive behavior, CRE-binding activity and BDNF level in learned helplessness rats. | European journal of pharmacology 20040913 |
| The effect of the indomethacin on phosphodiesterase inhibitors mediated responses in isolated trachea preparations. | Prostaglandins, leukotrienes, and essential fatty acids 20040901 |
| Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism. | British journal of pharmacology 20040901 |
| Selective inhibition of purified human phosphodiesterase 4A expressed in yeast cell GL62 by ciclamilast, piclamilast, and rolipram. | Acta pharmacologica Sinica 20040901 |
| The type IV-specific phosphodiesterase inhibitor rolipram and its effect on hippocampal long-term potentiation and synaptic tagging. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040901 |
| Cyclic nucleotide-dependent phosphodiesterases (PDEI) inhibition by muscarinic antagonists in bovine tracheal smooth muscle. | Biochemical pharmacology 20040815 |
| The synergistic effect of adenosine A2A receptors agonist, type IV phosphodiestease inhibitor and ATP-sensitive K channels activation on free radicals production and aggregation of human polymorphoneuclear leukocytes. | Pharmacological research 20040801 |
| Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. | Biochemical pharmacology 20040801 |
| Repetitive exposures to nicotine induce a hyper-responsiveness via the cAMP/PKA/CREB signal pathway in Drosophila. | Journal of neurobiology 20040801 |
| Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY. | Circulation research 20040723 |
| Modulation of matrix metalloproteinase production from human lung fibroblasts by type 4 phosphodiesterase inhibitors. | Life sciences 20040702 |
| Differential control of TH1 versus TH2 cell responses by the combination of low-dose steroids with beta2-adrenergic agonists. | The Journal of allergy and clinical immunology 20040701 |
| Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. | Journal of pharmacological sciences 20040701 |
| Identification of purine inhibitors of phosphodiesterase 7 (PDE7). | Bioorganic & medicinal chemistry letters 20040607 |
| Increased levels of cyclic adenosine monophosphate contribute to the hyporesponsiveness of mast cells in alloxan diabetes. | International immunopharmacology 20040601 |
| cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. | Nature medicine 20040601 |
| PDE4 inhibitors in COPD--a more selective approach to treatment. | Respiratory medicine 20040601 |
| Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4. | The Journal of pharmacy and pharmacology 20040601 |
| Forskolin-induced LTP in the CA1 hippocampal region is NMDA receptor dependent. | Journal of neurophysiology 20040501 |
| Adenovirus-mediated delivery and expression of a cAMP-dependent protein kinase inhibitor gene to BEAS-2B epithelial cells abolishes the anti-inflammatory effects of rolipram, salbutamol, and prostaglandin E2: a comparison with H-89. | The Journal of pharmacology and experimental therapeutics 20040501 |
| Augmentation of lipolysis in adipocytes from fed rats, but not from starved rats, by inhibition of rolipram-sensitive phosphodiesterase 4. | Archives of biochemistry and biophysics 20040501 |
| Phosphodiesterase type 4 inhibitor prevents acute lung injury induced by cardiopulmonary bypass in a rat model. | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20040501 |
| PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration. | Journal of cell science 20040501 |
| The Type IV phosphodiesterase inhibitor rolipram interferes with drug-induced conditioned place preference but not immediate early gene induction in mice. | The European journal of neuroscience 20040501 |
| Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. | Blood 20040401 |
| Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram. | Journal of molecular biology 20040319 |
| Pharmacological inhibition of Mannheimia haemolytica lipopolysaccharide and leukotoxin-induced cytokine expression in bovine alveolar macrophages. | Microbial pathogenesis 20040301 |
| Synthesis and biological evaluation of neutrophilic inflammation inhibitors. | Farmaco (Societa chimica italiana : 1989) 20040301 |
| [Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats]. | Nihon rinsho. Japanese journal of clinical medicine 20040301 |
| Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion. | Brain research 20040213 |
| Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors. | Biology of reproduction 20040201 |
| Antidiuretic hormone resistance in the neonatal cortical collecting tubule is mediated in part by elevated phosphodiesterase activity. | American journal of physiology. Renal physiology 20040201 |
| Inhibitory effects of group II mGluR-related drugs on memory performance in mice. | Physiology & behavior 20040201 |
| Rho GTPases and phosphoinositide 3-kinase organize formation of branched dendrites. | The Journal of biological chemistry 20040102 |
| Heterogeneity of neuronal and smooth muscle receptors involved in the VIP- and PACAP-induced relaxations of the pig intravesical ureter. | British journal of pharmacology 20040101 |
| Impact of cAMP on the T-cell response to type II collagen. | Immunology 20040101 |
| Phosphodiesterase 4 inhibition synergizes with relaxin signaling to promote decidualization of human endometrial stromal cells. | The Journal of clinical endocrinology and metabolism 20040101 |
| Early and late bronchoconstrictions, airway hyper-reactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040101 |
| Development of an in vitro model for vascular injury with human endothelial cells. | ALTEX 20040101 |
| Beta2-integrin adhesion caused by eotaxin but not IL-5 is blocked by PDE-4 inhibition and beta2-adrenoceptor activation in human eosinophils. | Pulmonary pharmacology & therapeutics 20040101 |
| Phosphodiesterase inhibitors: a novel mechanism for receptor-independent antipsychotic medications. | Neuroscience 20040101 |
| Phosphoinositide 3-kinase is involved in Xenopus and Labrus melanophore aggregation. | Cellular signalling 20031201 |
| Different regulation of adenylyl cyclase and rolipram-sensitive phosphodiesterase activity on the frontal cortex and hippocampus in learned helplessness rats. | Brain research 20031121 |
| Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. | British journal of pharmacology 20031101 |
| Lidocaine enhances Galphai protein function. | Anesthesiology 20031101 |
| Basal nitric oxide modulates vascular effects of a peptide activating protease-activated receptor 2. | Cardiovascular research 20031101 |
| Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process. | Cellular signalling 20031001 |
| Antidepressant-induced increase in high-affinity rolipram binding sites in rat brain: dependence on noradrenergic and serotonergic function. | The Journal of pharmacology and experimental therapeutics 20031001 |
| PDE4D plays a critical role in the control of airway smooth muscle contraction. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20031001 |
| Adenosine receptors and phosphodiesterase inhibitors stimulate Cl- secretion in Calu-3 cells. | American journal of respiratory cell and molecular biology 20030901 |
| Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7. | Cellular signalling 20030901 |
| Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. | The Journal of biological chemistry 20030829 |
| Blockade of LTC4 synthesis caused by additive inhibition of gIV-PLA2 phosphorylation: Effect of salmeterol and PDE4 inhibition in human eosinophils. | The Journal of allergy and clinical immunology 20030801 |
| Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors. | Bioorganic & medicinal chemistry letters 20030721 |
| Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics. | Bioorganic & medicinal chemistry letters 20030721 |
| Regulation of the cAMP-elevating effects of isoproterenol and forskolin in cardiac myocytes by treatments that cause increases in cAMP. | Biochemical and biophysical research communications 20030718 |
| Effect of phosphodiesterase type 4 on circadian clock gene Per1 transcription. | Biochemical and biophysical research communications 20030704 |
| Comparative actions of diazepam and other phosphodiesterase inhibitors on the effects of noradrenaline in rat myocardium. | Pharmacology & toxicology 20030701 |
| Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity. | Structure (London, England : 1993) 20030701 |
| Gamma-lactam synthesis via C-H insertion: elaboration of N-benzyl protecting groups for high regioselectivity toward the total synthesis of rolipram. | Organic letters 20030626 |
| Calcitonin gene related peptide and N-procalcitonin modulate CD11b upregulation in lipopolysaccharide activated monocytes and neutrophils. | Intensive care medicine 20030601 |
| Theophylline attenuates the adhesion of eosinophils to endothelial cells. | International archives of allergy and immunology 20030601 |
| Histamine up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and cAMP increase. | Medical science monitor : international medical journal of experimental and clinical research 20030601 |
| PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A. | Blood 20030515 |
| Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram. | The Journal of pharmacology and experimental therapeutics 20030501 |
| Resveratrol activates adenylyl-cyclase in human breast cancer cells: a novel, estrogen receptor-independent cytostatic mechanism. | Carcinogenesis 20030501 |
| Rolipram, a specific type IV phosphodiesterase inhibitor, ameliorates indomethacin-induced gastric mucosal injury in rats. | Pathophysiology : the official journal of the International Society for Pathophysiology 20030501 |
| Effect of rolipram on muscarinic acetylcholine receptor binding in the intact mouse brain. | Journal of neural transmission (Vienna, Austria : 1996) 20030401 |
| In vitro and ex vivo effects of the phosphodiesterase 4 inhibitor, rolipram, on thromboxane production in equine blood. | Journal of veterinary pharmacology and therapeutics 20030401 |
| [Physiopathology of COPD: choosing the right therapeutic targets]. | Revue de pneumologie clinique 20030401 |
| Subthreshold doses of nebulized prostacyclin and rolipram synergistaically protect against lung ischemia-reperfusion. | Transplantation 20030327 |
| Effects of rolipram, pimobendan and zaprinast on ischaemia-induced dysrhythmias and on ventricular cyclic nucleotide content in the anaesthetized rat. | European journal of anaesthesiology 20030301 |
| Effect of theophylline and specific phosphodiesterase IV inhibition on proliferation and apoptosis of progenitor cells in bronchial asthma. | British journal of pharmacology 20030301 |
| Involvement of cyclic AMP-mediated pathway in neural release of noradrenaline in canine isolated mesenteric artery and vein. | Cardiovascular research 20030101 |
| Effect of the phosphodiesterase 4 inhibitor, rolipram, on retinoic acid-increased alkaline phosphatase activity in the mouse fibroblastic C3H10T1/2 cell line. | Archives of oral biology 20030101 |
| Pharmacology of a new cyclic nucleotide phosphodiesterase type 4 inhibitor, V11294. | Pulmonary pharmacology & therapeutics 20030101 |
| Later developments: molecular keys to age-related memory impairment. | Alzheimer disease and associated disorders 20030101 |
| Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis. | Arthritis research & therapy 20030101 |
| AQP3, p-AQP2, and AQP2 expression is reduced in polyuric rats with hypercalcemia: prevention by cAMP-PDE inhibitors. | American journal of physiology. Renal physiology 20021201 |
| Use of near-infrared reflection spectroscopy to study the effects of X-ray contrast media on renal tolerance in rats: effects of a prostacyclin analogue and of phosphodiesterase inhibitors. | Investigative radiology 20021201 |
| Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20021115 |
| Development of a catalytic enantioselective conjugate addition of 1,3-dicarbonyl compounds to nitroalkenes for the synthesis of endothelin-A antagonist ABT-546. Scope, mechanism, and further application to the synthesis of the antidepressant rolipram. | Journal of the American Chemical Society 20021106 |
| Inhibition of human phosphodiesterase 4A expressed in yeast cell GL62 by theophylline, rolipram, and acetamide-45. | Acta pharmacologica Sinica 20021101 |
| Enhancement of the relative uptake of 18F-FDG in mouse fibrosarcoma by rolipram. | Annals of nuclear medicine 20021101 |
| Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021001 |
| Cyclic AMP-mediated modulation of epileptiform afterdischarge generation in rat hippocampal slices. | Brain research 20020913 |
| The effects of cAMP modulation upon the adhesion and respiratory burst activity of immune complex-stimulated equine neutrophils. | Veterinary immunology and immunopathology 20020906 |
| A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5. | Bioorganic & medicinal chemistry letters 20020902 |
| Rolipram depresses [(3)H]2-deoxyglucose uptake in mouse brain and heart in vivo. | European journal of nuclear medicine and molecular imaging 20020901 |
| Effects of rolipram on in vivo dopamine receptor binding. | Journal of neural transmission (Vienna, Austria : 1996) 20020901 |
| Comparison of the effects of cilostazol and milrinone on cAMP-PDE activity, intracellular cAMP and calcium in the heart. | Cardiovascular drugs and therapy 20020901 |
| Immunosuppressants leflunomide and mycophenolic acid inhibit fibroblast IL-6 production by distinct mechanisms. | Cytokine 20020821 |
| Benefit of phosphodiesterase 4 inhibitors as supplemental therapy after lung transplantation concerning their antiproliferative effects: an experimental study using a heterotopic rodent model. | Transplantation 20020815 |
| Phosphodiesterase 3 inhibitors selectively block the spontaneous resumption of meiosis by macaque oocytes in vitro. | Human reproduction (Oxford, England) 20020801 |
| Changes in phosphodiesterase activity in the developing rat submandibular gland. | Archives of oral biology 20020801 |
| Pharmacology of N-(3,5-dichloro-1-oxido-4-pyridinyl)-8-methoxy-2-(trifluoromethyl)-5-quinoline carboxamide (SCH 351591), a novel, orally active phosphodiesterase 4 inhibitor. | The Journal of pharmacology and experimental therapeutics 20020701 |
| Hydrolysis of N-methyl-D-aspartate receptor-stimulated cAMP and cGMP by PDE4 and PDE2 phosphodiesterases in primary neuronal cultures of rat cerebral cortex and hippocampus. | The Journal of pharmacology and experimental therapeutics 20020701 |
| Airway function, oedema, cell infiltration and nitric oxide generation in conscious ozone-exposed guinea-pigs: effects of dexamethasone and rolipram. | British journal of pharmacology 20020701 |
| Crystal structure of 5-t-butoxycarbonyl-1-benzoyl-2-pyrrolidinone, an intermediate in the synthesis of (-)-rolipram. | Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020701 |
| 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. | Bioorganic & medicinal chemistry letters 20020617 |
| Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones. | Journal of medicinal chemistry 20020606 |
| Phosphodiesterase type 4 inhibitor reduces the retention of polymorphonuclear leukocytes in the lung. | American journal of physiology. Lung cellular and molecular physiology 20020601 |
| Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). | British journal of pharmacology 20020601 |
| DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. | Naunyn-Schmiedeberg's archives of pharmacology 20020601 |
| Relaxation induced by milrinone and rolipram in human penile arteries and veins. | European journal of pharmacology 20020524 |
| Functional plasticity of cyclic AMP hydrolysis in rat adenohypophysial corticotroph cells. | Cellular signalling 20020501 |
| Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C. | The Journal of pharmacology and experimental therapeutics 20020501 |
| Inhibition of PDE4 phosphodiesterase activity induces growth suppression, apoptosis, glucocorticoid sensitivity, p53, and p21(WAF1/CIP1) proteins in human acute lymphoblastic leukemia cells. | Blood 20020501 |
| Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium. | British journal of pharmacology 20020501 |
| Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Airway relaxant and anti-inflammatory properties of a PDE4 inhibitor with low affinity for the high-affinity rolipram binding site. | Naunyn-Schmiedeberg's archives of pharmacology 20020401 |
| Endotoxin potentiation of trichothecene-induced lymphocyte apoptosis is mediated by up-regulation of glucocorticoids. | Toxicology and applied pharmacology 20020401 |
| Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro. | Diseases of the colon and rectum 20020401 |
| Cardiac myocyte adenosine A2a receptor activation fails to alter cAMP or contractility: role of receptor localization. | American journal of physiology. Heart and circulatory physiology 20020301 |
| Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors. | Bioorganic & medicinal chemistry letters 20020225 |
| Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4). | Biochemical pharmacology 20020215 |
| Involvement of phosphodiesterase isozymes in osteoblastic differentiation. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020201 |
| The effects of intravenous anesthetics and lidocaine on proliferation of cultured type II pneumocytes and lung fibroblasts. | Anesthesia and analgesia 20020201 |
| Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. | Clinical cancer research : an official journal of the American Association for Cancer Research 20020201 |
| Selective phosphodiesterase type 4 inhibitors reduce the prolonged survival of eosinophils stimulated by granulocyte-macrophage colony-stimulating factor. | Biological & pharmaceutical bulletin 20020201 |
| Cyclic AMP-specific phosphodiesterase 4 inhibitors promote ABCA1 expression and cholesterol efflux. | Biochemical and biophysical research communications 20020118 |
| Phthalazine PDE4 inhibitors. Part 3: the synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor. | Bioorganic & medicinal chemistry letters 20020107 |
| Cyclic adenosine monophosphate-dependent vascular responses to purinergic agonists adenosine triphosphate and uridine triphosphate in the anesthetized mouse. | Journal of cardiovascular pharmacology 20020101 |
| Peptidergic and nitrergic inhibitory neurotransmissions in the hamster jejunum: regulation of vasoactive intestinal peptide release by nitric oxide. | Neuroscience 20020101 |
| Participation of peripheral and spinal phosphodiesterases 4 and 5 in inflammatory pain. | Proceedings of the Western Pharmacology Society 20020101 |
| Facilitation of dopaminergic neural transmission does not affect [(11)C]SCH23390 binding to the striatal D(1) dopamine receptors, but the facilitation enhances phosphodiesterase type-IV activity through D(1) receptors: PET studies in the conscious monkey brain. | Synapse (New York, N.Y.) 20011215 |
| Differential effect of phosphodiesterase inhibitors on IL-13 release from peripheral blood mononuclear cells. | Clinical and experimental immunology 20011201 |
| cAMP-elevating agents suppress dendritic cell function. | Journal of leukocyte biology 20011201 |
| Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle. | European journal of pharmacology 20011102 |
| Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. | The Journal of pharmacology and experimental therapeutics 20011101 |
| Differential phosphodiesterase activity contributes to restrictive endothelial barrier function during angiogenesis. | Microvascular research 20011101 |
| The kinetics, function, and regulation of P-selectin expressed by human brain microvessel endothelial cells in primary culture. | Microvascular research 20011101 |
| Effects of inhibition of PDE4 and TNF-alpha on local and remote injuries following ischaemia and reperfusion injury. | British journal of pharmacology 20011101 |
| Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats. | Psychopharmacology 20011101 |
| Phosphodiesterase type 4 inhibitor suppresses expression of anti-apoptotic members of the Bcl-2 family in B-CLL cells and induces caspase-dependent apoptosis. | Leukemia 20011001 |
| Suppression of granulocyte/macrophage colony-stimulating factor release from human monocytes by cyclic AMP-elevating drugs: role of interleukin-10. | British journal of pharmacology 20010901 |
| Modulation of eotaxin formation and eosinophil migration by selective inhibitors of phosphodiesterase type 4 isoenzyme. | British journal of pharmacology 20010901 |
| Dissecting the cofactor-dependent and independent bindings of PDE4 inhibitors. | Biochemistry 20010828 |
| Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. | Life sciences 20010824 |
| First highly regio- and diastereoselective [3+2] cycloaddition of chiral nonracemic Fischer carbene complexes with azomethine ylides: an enantioselective synthesis of (+)-rolipram. | Chemistry (Weinheim an der Bergstrasse, Germany) 20010817 |
| Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A. | Journal of immunology (Baltimore, Md. : 1950) 20010815 |
| Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones. | Journal of medicinal chemistry 20010802 |
| Systemic and topical drug administration in the pig ureter: effect of phosphodiesterase inhibitors alpha1, beta and beta2-adrenergic receptor agonists and antagonists on the frequency and amplitude of ureteral contractions. | The Journal of urology 20010801 |
| Diazepam increases the hypothalamic-pituitary-adrenocortical (HPA) axis activity by a cyclic AMP-dependent mechanism. | British journal of pharmacology 20010801 |
| Inhibitors of phosphodiesterase isoforms III or IV suppress islet-cell nitric oxide production. | Laboratory investigation; a journal of technical methods and pathology 20010801 |
| Synthesis and structure-activity relationship of N-arylrolipram derivatives as inhibitors of PDE4 isozymes. | Chemical & pharmaceutical bulletin 20010801 |
| Differential inhibition of equine neutrophil function by phosphodiesterase inhibitors. | Journal of veterinary pharmacology and therapeutics 20010801 |
| Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: effect of rolipram and dexamethasone. | The Journal of pharmacology and experimental therapeutics 20010701 |
| Identification and quantification of phosphodiesterase 4 subtypes in CD4 and CD8 lymphocytes from healthy and asthmatic subjects. | British journal of pharmacology 20010701 |
| Vasodilator responses to ATP and UTP are cAMP dependent in the mesenteric vascular bed of the cat. | Journal of cardiovascular pharmacology and therapeutics 20010701 |
| Noradrenaline modulates oyster hemocyte phagocytosis via a beta-adrenergic receptor-cAMP signaling pathway. | General and comparative endocrinology 20010601 |
| Enhanced protection from renal ischemia-reperfusion [correction of ischemia:reperfusion] injury with A(2A)-adenosine receptor activation and PDE 4 inhibition. | Kidney international 20010601 |
| Modulation of thapsigargin-induced calcium mobilisation by cyclic AMP-elevating agents in human lymphocytes is insensitive to the action of the protein kinase A inhibitor H-89. | Cellular signalling 20010601 |
| Maintenance of cAMP in non-heart-beating donor lungs reduces ischemia-reperfusion injury. | American journal of respiratory and critical care medicine 20010601 |
| Role of cyclic nucleotide phosphodiesterase isoenzymes in contractile responses of denuded rat aorta related to various Ca2+ sources. | Naunyn-Schmiedeberg's archives of pharmacology 20010601 |
| Effects of PDE4 inhibitors on lipopolysaccharide-induced priming of superoxide anion production from human mononuclear cells. | Mediators of inflammation 20010601 |
| Rolipram reduces excitotoxic neuronal damage. | Neuroreport 20010525 |
| Characterization of r-[11C]rolipram for PET imaging of phosphodieterase-4: in vivo binding, metabolism, and dosimetry studies in rats. | Nuclear medicine and biology 20010501 |
| Design of rolipram-loaded nanoparticles: comparison of two preparation methods. | Journal of controlled release : official journal of the Controlled Release Society 20010428 |
| Requirement of additional adenylate cyclase activation for the inhibition of human eosinophil degranulation by phosphodiesterase IV inhibitors. | European journal of pharmacology 20010406 |
| Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K(+) channels and nitric oxide. | European journal of pharmacology 20010406 |
| Type IV phosphodiesterase inhibitor suppresses insulin-dependent myocardial glucose uptake. | Clinical and experimental pharmacology & physiology 20010401 |
| Identification of inhibitor binding sites of the cAMP-specific phosphodiesterase 4. | Cellular signalling 20010401 |
| Buchu (Agathosma betulina and A. crenulata, Rutaceae) essential oils: their pharmacological action on guinea-pig ileum and antimicrobial activity on microorganisms. | The Journal of pharmacy and pharmacology 20010401 |
| Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. | Biochimica et biophysica acta 20010319 |
| Syntheses and evaluation of pyrido[2,3-dlpyrimidine-2,4-diones as PDE 4 inhibitors. | Bioorganic & medicinal chemistry letters 20010312 |
| Involvement of cyclic AMP systems in morphine physical dependence in mice: prevention of development of morphine dependence by rolipram, a phosphodiesterase 4 inhibitor. | British journal of pharmacology 20010301 |
| Identification of substrate specificity determinants in human cAMP-specific phosphodiesterase 4A by single-point mutagenesis. | Cellular signalling 20010301 |
| The influence of phosphodiesterase inhibitor, rolipram, on hemodynamics in lipopolysaccharide-treated rats. | Japanese journal of pharmacology 20010301 |
| Structure-activity relationships of quinazoline derivatives: dual-acting compounds with inhibitory activities toward both TNF-alpha production and T cell proliferation. | Bioorganic & medicinal chemistry letters 20010226 |
| Inflammation contributes to the postponed ischemic neuronal damage following treatment with a glutamate antagonist in rats. | Neuroscience letters 20010202 |
| The phosphodiesterase inhibitors pentoxifylline and rolipram suppress macrophage activation and nitric oxide production in vitro and in vivo. | Clinical immunology (Orlando, Fla.) 20010201 |
| Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives. | Bioorganic & medicinal chemistry letters 20010108 |
| A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice. | Behavioural brain research 20010108 |
| PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway. | Neuropharmacology 20010101 |
| Regulation of TNF-alpha-induced eotaxin release from cultured human airway smooth muscle cells by beta2-agonists and corticosteroids. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010101 |
| Inhibition of phosphodiesterase 4 attenuates airway hyperresponsiveness and airway inflammation in a model of secondary allergen challenge. | American journal of respiratory and critical care medicine 20010101 |
| [Suppression of synthesis of tumor necrosis factor]. | Der Internist 20010101 |
| Comparison of PDE 4 inhibitors, rolipram and SB 207499 (ariflo), in a rat model of pulmonary neutrophilia. | Pulmonary pharmacology & therapeutics 20010101 |
| [Inhibition of uterine contractions: new in vitro pharmacological approaches on the pregnant human myometrium]. | Therapie 20010101 |
| The antidepressant and antiinflammatory effects of rolipram in the central nervous system. | CNS drug reviews 20010101 |
| Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil peroxidase (EPO) levels following either systemic or intratracheal administration in sephadex- or ovalbumin-induced inflammatory models. | Inflammation 20000801 |
| Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells. | FEBS letters 20000721 |
| beta-Adrenoceptor stimulation up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils. | Naunyn-Schmiedeberg's archives of pharmacology 20000401 |
| Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia. | British journal of pharmacology 19990601 |
| The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform. | The Journal of biological chemistry 19990521 |
| SB 207499 (Ariflo), a second generation phosphodiesterase 4 inhibitor, reduces tumor necrosis factor alpha and interleukin-4 production in vivo. | The Journal of pharmacology and experimental therapeutics 19981101 |
| Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors. | The Journal of allergy and clinical immunology 19981101 |
| Exogenous and endogenous catecholamines inhibit the production of macrophage inflammatory protein (MIP) 1 alpha via a beta adrenoceptor mediated mechanism. | British journal of pharmacology 19981101 |
| Inhibition of phosphodiesterase type IV suppresses human immunodeficiency virus type 1 replication and cytokine production in primary T cells: involvement of NF-kappaB and NFAT. | Journal of virology 19980601 |
| SB 207499 (Ariflo), a potent and selective second-generation phosphodiesterase 4 inhibitor: in vitro anti-inflammatory actions. | The Journal of pharmacology and experimental therapeutics 19980101 |
| CDP840: a novel inhibitor of PDE-4. | Cell biochemistry and biophysics 19980101 |
| Theophylline accelerates human granulocyte apoptosis not via phosphodiesterase inhibition. | The Journal of clinical investigation 19971001 |
| Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. | Biochemical and biophysical research communications 19970519 |
| The effect of selective phosphodiesterase 3 and 4 isoenzyme inhibitors and established anti-asthma drugs on inflammatory cell activation. | British journal of pharmacology 19961101 |
| Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 19960401 |
| Delayed sympathectomy after a prolonged hyperalgesia results in a subsequent enhanced acute hyperalgesic response. | Neuroscience 19960401 |
| Action of cAMP on expression and release of adhesion molecules in human endothelial cells. | The American journal of physiology 19960301 |
| Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. | European journal of pharmacology 19960205 |
| Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram. | Cellular signalling 19960201 |
| Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication. | AIDS (London, England) 19951001 |
| Studies on anti-allergic action of AH 21-132, a novel isozyme-selective phosphodiesterase inhibitor in airways. | Japanese journal of pharmacology 19950201 |
| Multiple second messenger systems act sequentially to mediate rolipram-induced prolongation of prostaglandin E2-induced mechanical hyperalgesia in the rat. | Neuroscience 19950201 |
| Isolation and characterization of ovokinin, a bradykinin B1 agonist peptide derived from ovalbumin. | Peptides 19950101 |
| Central and peripheral minocycline suppresses motor activity in rats. | Pharmacology, biochemistry, and behavior 19930201 |
| Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia. | Neuroscience 19910101 |
| Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. | Pharmacology, biochemistry, and behavior 19900801 |
| Caffeine and panic attacks. | The British journal of psychiatry : the journal of mental science 19870501 |