Shogaol
| Title | Journal |
|---|---|
| The hidden mechanism beyond ginger (Zingiber officinale Rosc.) potent in vivo and in vitro anti-inflammatory activity. | Journal of ethnopharmacology 20180325 |
| Oral Delivery of Nanoparticles Loaded With Ginger Active Compound, 6-Shogaol, Attenuates Ulcerative Colitis and Promotes Wound Healing in a Murine Model of Ulcerative Colitis. | Journal of Crohn's & colitis 20180101 |
| 6-Shogaol ameliorates diabetic nephropathy through anti-inflammatory, hyperlipidemic, anti-oxidative activity in db/db mice. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20180101 |
| 6-Shogaol attenuates LPS-induced inflammation in BV2 microglia cells by activating PPAR-γ. | Oncotarget 20170627 |
| [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na(+) channels. | Pharmacological research 20170301 |
| Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3β and β-catenin pathway in A549 cell line. | Chemico-biological interactions 20161025 |
| 6-Shogaol enhances renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated cytochrome c release and down-regulation of c-FLIP(L) expression. | Chemico-biological interactions 20150225 |
| Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo. | Chemical research in toxicology 20140915 |
| A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways. | Toxicology and applied pharmacology 20131101 |
| In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. | Food chemistry 20121115 |
| Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice. | Atherosclerosis 20121101 |
| Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015 |
| 6-Shogaol, a ginger product, modulates neuroinflammation: a new approach to neuroprotection. | Neuropharmacology 20120801 |
| Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. | Molecular nutrition & food research 20120801 |
| 6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice. | Molecules (Basel, Switzerland) 20120704 |
| Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study. | Journal of the science of food and agriculture 20120701 |
| Effects of [6]-shogaol on cholinergic signaling in HT22 cells following neuronal damage induced by hydrogen peroxide. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501 |
| Metabolism of [6]-shogaol in mice and in cancer cells. | Drug metabolism and disposition: the biological fate of chemicals 20120401 |
| Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. | Fitoterapia 20120401 |
| Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. | Phytotherapy research : PTR 20120301 |
| Protection by [6]-shogaol against lipopolysaccharide-induced toxicity in murine astrocytes is related to production of brain-derived neurotrophic factor. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301 |
| Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. | Bioorganic & medicinal chemistry letters 20120215 |
| 4-Shogaol, an active constituent of dietary ginger, inhibits metastasis of MDA-MB-231 human breast adenocarcinoma cells by decreasing the repression of NF-κB/Snail on RKIP. | Journal of agricultural and food chemistry 20120125 |
| Anti-inflammatory effects of [6]-shogaol: potential roles of HDAC inhibition and HSP70 induction. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101 |
| Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. | Journal of medicinal chemistry 20110922 |
| Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography. | Journal of chromatography. A 20110909 |
| Examination of the pharmacokinetics of active ingredients of ginger in humans. | The AAPS journal 20110901 |
| Shogaols at proapoptotic concentrations induce G(2)/M arrest and aberrant mitotic cell death associated with tubulin aggregation. | Apoptosis : an international journal on programmed cell death 20110801 |
| Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. | Planta medica 20110701 |
| Update on the chemopreventive effects of ginger and its phytochemicals. | Critical reviews in food science and nutrition 20110701 |
| Ginger suppresses phthalate ester-induced airway remodeling. | Journal of agricultural and food chemistry 20110413 |
| Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. | Journal of agricultural and food chemistry 20101222 |
| Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii. | Phytotherapy research : PTR 20101201 |
| 6-Shogaol, an active constituent of ginger, inhibits breast cancer cell invasion by reducing matrix metalloproteinase-9 expression via blockade of nuclear factor-κB activation. | British journal of pharmacology 20101201 |
| Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. | Molecular nutrition & food research 20101101 |
| Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. | Planta medica 20101101 |
| 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. | Molecular nutrition & food research 20100901 |
| Effect of [6]-shogaol on cytosolic Ca2+ levels and proliferation in human oral cancer cells (OC2). | Journal of natural products 20100827 |
| Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I). | Journal of natural medicines 20100701 |
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. | Bioorganic & medicinal chemistry 20100501 |
| Induction of apoptosis by [8]-shogaol via reactive oxygen species generation, glutathione depletion, and caspase activation in human leukemia cells. | Journal of agricultural and food chemistry 20100324 |
| Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. | Journal of ethnopharmacology 20100203 |
| 6-Shogaol inhibits monosodium urate crystal-induced inflammation--an in vivo and in vitro study. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101 |
| Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. | Journal of agricultural and food chemistry 20091125 |
| 6-Shogaol, an active constituent of dietary ginger, induces autophagy by inhibiting the AKT/mTOR pathway in human non-small cell lung cancer A549 cells. | Journal of agricultural and food chemistry 20091028 |
| Six-shogaol inhibits production of tumour necrosis factor alpha, interleukin-1 beta and nitric oxide from lipopolysaccharide-stimulated RAW 264.7 macrophages. | The West Indian medical journal 20090901 |
| Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. | British journal of pharmacology 20090801 |
| TBK1-targeted suppression of TRIF-dependent signaling pathway of Toll-like receptors by 6-shogaol, an active component of ginger. | Bioscience, biotechnology, and biochemistry 20090701 |
| Inhibition of homodimerization of toll-like receptor 4 by 6-shogaol. | Molecules and cells 20090227 |
| Modulation of macrophage functions by compounds isolated from Zingiber officinale. | Planta medica 20090201 |
| Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. | Bioorganic & medicinal chemistry 20081215 |
| 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. | Molecular nutrition & food research 20081201 |
| Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage. | FEBS letters 20081015 |
| Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia. | The Journal of pharmacy and pharmacology 20081001 |
| 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. | Biochemical and biophysical research communications 20080829 |
| Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080801 |
| Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe.) during maturation. | Journal of agricultural and food chemistry 20080723 |
| 6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. | Molecular nutrition & food research 20080501 |
| [RP-HPLC fingerprint evaluating different ginger juice as processing material]. | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501 |
| Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. | Archives of pharmacal research 20080401 |
| Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. | Journal of pharmaceutical and biomedical analysis 20071130 |
| Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. | Biochemical and biophysical research communications 20071012 |
| 6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism. | Journal of agricultural and food chemistry 20070207 |
| Liquid chromatographic determination of 6-, 8-, 10-gingerol, and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract. | Journal of AOAC International 20070101 |
| 6-Shogaol, a natural product, reduces cell death and restores motor function in rat spinal cord injury. | The European journal of neuroscience 20060801 |
| Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. | European journal of pharmacology 20060113 |
| 6-Shogaol reduced chronic inflammatory response in the knees of rats treated with complete Freund's adjuvant. | BMC pharmacology 20060101 |
| A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1. | Nutritional neuroscience 20060101 |
| Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. | Vascular pharmacology 20051001 |
| Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities. | Journal of natural products 20040701 |
| Side-chain length is important for shogaols in protecting neuronal cells from beta-amyloid insult. | Bioorganic & medicinal chemistry letters 20040308 |
| Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori. | Anticancer research 20030101 |
| Component of Zingiber officinale that improves the enhancement of small intestinal transport. | Planta medica 20021001 |
| Shogaols from Zingiber officinale as promising antifouling agents. | Bioscience, biotechnology, and biochemistry 20020801 |
| Shogaols from Zingiber officinale protect IMR32 human neuroblastoma and normal human umbilical vein endothelial cells from beta-amyloid(25-35) insult. | Planta medica 20020401 |
| The herbal medicine Dai-kenchu-to and one of its active components [6]-shogaol increase intestinal blood flow in rats. | Life sciences 20020315 |
| Structure-antiemetic-activity of some diarylheptanoids and their analogues. | Phytomedicine : international journal of phytotherapy and phytopharmacology 20020301 |
| The stability of gingerol and shogaol in aqueous solutions. | Journal of pharmaceutical sciences 20011001 |
| Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes. | Pest management science 20010301 |