Methyl 6,7-dimethoxy-4-ethyl-β-carboline-3-carboxylate
| Title | Journal |
|---|---|
| DMCM, a benzodiazepine site inverse agonist, improves active avoidance and motivation in the rat. | Behavioural brain research 20121201 |
| Rats with different thresholds to clonic convulsions induced by DMCM differ in the binding of [3H]-MK-801 and [3H]-ouabain in the membranes of brain regions. | Neurochemical research 20120701 |
| Rats with different thresholds for DMCM-induced clonic convulsions differ in the sleep-time of diazepam and [(3)H]-Ro 15-4513 binding. | Epilepsy research 20120201 |
| Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation. | European journal of pharmacology 20110901 |
| Characterization of GABA(A) receptors expressed in glial cell membranes of adult mouse neocortex using a Xenopus oocyte microtransplantation expression system. | Journal of neuroscience methods 20110515 |
| Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines. | British journal of pharmacology 20110201 |
| Removal of GABA(A) receptor γ2 subunits from parvalbumin neurons causes wide-ranging behavioral alterations. | PloS one 20110101 |
| Developing dual functional allosteric modulators of GABA(A) receptors. | Bioorganic & medicinal chemistry 20101201 |
| Anticonvulsant effects of methyl ethyl ketone and diethyl ketone in several types of mouse seizure models. | European journal of pharmacology 20100910 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Similar anxiolytic-like effects following intra-amygdala infusions of benzodiazepine receptor agonist and antagonist: evidence for the release of an endogenous benzodiazepine inverse agonist in mice exposed to elevated plus-maze test. | Brain research 20090424 |
| Expression levels of the alpha4 subunit of the GABA(A) receptor in differentiated neuroblastoma cells are correlated with GABA-gated current. | Neuropharmacology 20090101 |
| A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells. | Assay and drug development technologies 20081201 |
| PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats. | Brain research 20080507 |
| Structural mechanisms underlying benzodiazepine modulation of the GABA(A) receptor. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080326 |
| Chemoconvulsant-induced seizure susceptibility: toward a common genetic basis? | Epilepsia 20070101 |
| Effects of stress modulation on morphine-induced conditioned place preferences and plasma corticosterone levels in Fischer, Lewis, and Sprague-Dawley rat strains. | Psychopharmacology 20061201 |
| Mechanism of action of benzodiazepines on GABAA receptors. | British journal of pharmacology 20060801 |
| Pharmacological properties of GABAA receptors containing gamma1 subunits. | Molecular pharmacology 20060201 |
| Behavioral differences between subgroups of rats with high and low threshold to clonic convulsions induced by DMCM, a benzodiazepine inverse agonist. | Pharmacology, biochemistry, and behavior 20051101 |
| Negative GABA(A) modulators attenuate the discriminative stimulus effects of benzodiazepines and the neuroactive steroid pregnanolone in rhesus monkeys. | Psychopharmacology 20051001 |
| Targeted invalidation of CCK2 receptor gene induces anxiolytic-like action in light-dark exploration, but not in fear conditioning test. | Psychopharmacology 20050901 |
| Bidirectional effects of benzodiazepine binding site ligands on active avoidance acquisition and retention: differential antagonism by flumazenil and beta-CCt. | Psychopharmacology 20050701 |
| Bidirectional effects of benzodiazepine binding site ligands in the passive avoidance task: differential antagonism by flumazenil and beta-CCt. | Behavioural brain research 20050330 |
| Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. | Neuropharmacology 20050301 |
| An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. | Journal of medicinal chemistry 20041118 |
| Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors. | The Journal of pharmacology and experimental therapeutics 20041101 |
| Electrophysiological properties of mouse horizontal cell GABAA receptors. | Journal of neurophysiology 20041101 |
| Bidirectional effects of benzodiazepine binding site ligands in the elevated plus-maze: differential antagonism by flumazenil and beta-CCt. | Pharmacology, biochemistry, and behavior 20041001 |
| Seizure susceptibility to various convulsant stimuli in dystrophin-deficient mdx mice. | Neuroscience research 20040901 |
| 3,4-Dihydronaphthalen-1(2H)-ones: novel ligands for the benzodiazepine site of alpha5-containing GABAA receptors. | Bioorganic & medicinal chemistry letters 20040607 |
| Seizure susceptibility to various convulsant stimuli of knockout interleukin-6 mice. | Pharmacology, biochemistry, and behavior 20040401 |
| Neuroscience. Blocking plasticity in the visual cortex. | Science (New York, N.Y.) 20040312 |
| Columnar architecture sculpted by GABA circuits in developing cat visual cortex. | Science (New York, N.Y.) 20040312 |
| Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. | Journal of neurochemistry 20040301 |
| Potential pleiotropic effects of Mpdz on vulnerability to seizures. | Genes, brain, and behavior 20040201 |
| Augmentation of the NO-cGMP cascade induces anxiogenic-like effect in mice. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20031201 |
| Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice. | Psychopharmacology 20030901 |
| Benzodiazepine agonist and inverse agonist coupling in GABAA receptors antagonized by increased atmospheric pressure. | European journal of pharmacology 20030523 |
| Identification of a novel, selective GABA(A) alpha5 receptor inverse agonist which enhances cognition. | Journal of medicinal chemistry 20030522 |
| Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations. | The Journal of pharmacology and experimental therapeutics 20030101 |
| Functional characterization of GABA(A) receptors in neonatal hypothalamic brain slice. | Journal of neurophysiology 20021001 |
| Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. | Neuropharmacology 20020901 |
| Stress-induced deoxycorticosterone-derived neurosteroids modulate GABA(A) receptor function and seizure susceptibility. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501 |
| 3-Heteroaryl-2-pyridones: benzodiazepine site ligands with functional delectivity for alpha 2/alpha 3-subtypes of human GABA(A) receptor-ion channels. | Journal of medicinal chemistry 20020425 |
| 6,7-Dihydro-2-benzothiophen-4(5H)-ones: a novel class of GABA-A alpha5 receptor inverse agonists. | Journal of medicinal chemistry 20020314 |
| Daily treatment with diazepam differentially modifies sensitivity to the effects of gamma-aminobutyric acid(A) modulators on schedule-controlled responding in rhesus monkeys. | The Journal of pharmacology and experimental therapeutics 20020301 |
| Pharmacological heterogeneity of gamma-aminobutyric acid receptors during development suggests distinct classes of rat cerebellar granule cells in situ. | Neuropharmacology 20020101 |
| Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives. | Bioorganic & medicinal chemistry 20011101 |
| GABA(A) receptor epsilon-subunit may confer benzodiazepine insensitivity to the caudal aspect of the nucleus tractus solitarii of the rat. | The Journal of physiology 20011101 |
| Protective effects of cannabinoid receptor agonists against cocaine and other convulsant-induced toxic behavioural symptoms. | The Journal of pharmacy and pharmacology 20011101 |
| Influence of benzodiazepine binding site ligands on fear-conditioned contextual memory. | European journal of pharmacology 20010824 |
| Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors. | Journal of medicinal chemistry 20010621 |
| Functional pharmacology of GABA(A) receptors containing the chicken brain gamma 4 subunit. | European journal of pharmacology 20010504 |
| The octadecaneuropeptide ODN stimulates neurosteroid biosynthesis through activation of central-type benzodiazepine receptors. | Journal of neurochemistry 20010101 |
| Pain and negative affect: evidence the inverse benzodiazepine agonist DMCM inhibits pain and learning in rats. | Psychopharmacology 20010101 |
| Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. | Journal of medicinal chemistry 20000113 |
| Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex. | Journal of medicinal chemistry 19991021 |
| Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. | European journal of pharmacology 19980724 |
| Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors. | Journal of medicinal chemistry 19980702 |
| Cocaine: evidence for NMDA-, beta-carboline- and dopaminergic-mediated seizures in mice. | Brain research 19980629 |
| Hypersusceptibility to DMCM-induced seizures during diazepam withdrawal in mice: evidence for upregulation of NMDA receptors. | Naunyn-Schmiedeberg's archives of pharmacology 19980301 |
| The influence of the antidepressant pirlindole and its dehydro-derivative on the activity of monoamine oxidase A and GABAA receptor binding. | Journal of neural transmission. Supplementum 19980101 |
| Cerebellar gamma-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. | Molecular pharmacology 19970901 |
| Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain. | The Journal of pharmacology and experimental therapeutics 19931101 |
| [Effects of agonists and antagonists of benzodiazepine, GABA and NMDA receptors, on caffeine-induced seizures in mice]. | Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology 19920801 |
| Yohimbine-induced seizures involve NMDA and GABAergic transmission. | Neuropharmacology 19920401 |
| Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents. | Epilepsia 19920101 |
| Nitrendipine decreases benzodiazepine withdrawal seizures but not the development of benzodiazepine tolerance or withdrawal signs. | British journal of pharmacology 19901101 |
| GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAs displays potentiation by benzodiazepine receptor ligands. | Brain research. Molecular brain research 19900801 |
| Adenosine receptor antagonism accounts for the seizure-prolonging effects of aminophylline. | Pharmacology, biochemistry, and behavior 19900801 |
| Anticonvulsant action of the beta-carboline abecarnil: studies in rodents and baboon, Papio papio. | The Journal of pharmacology and experimental therapeutics 19900401 |
| Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat. | European journal of pharmacology 19890117 |
| Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone. | Epilepsia 19890101 |
| Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142. | Brain research bulletin 19870901 |
| Bidirectional effects of beta-carbolines in reflex epilepsy. | Brain research bulletin 19870901 |
| Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM. | Pharmacology, biochemistry, and behavior 19870701 |
| Differential effects of gamma-hexachlorocyclohexane (lindane) on pharmacologically-induced seizures. | Archives of toxicology 19870401 |
| Coincidence of seizure susceptibility to caffeine and to the benzodiazepine inverse agonist, DMCM, in SWR and CBA inbred mice. | Pharmacology, biochemistry, and behavior 19870201 |