Bromopyruvic acid
| Title | Journal |
|---|---|
| Antitumor and chemosensitizing action of 3-bromopyruvate: Implication of deregulated metabolism. | Chemico-biological interactions 20170525 |
| Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer. | Journal of bioenergetics and biomembranes 20150101 |
| Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation. | The Journal of pharmacology and experimental therapeutics 20140201 |
| MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors. | Nature genetics 20130101 |
| D-Amino acid oxidase-induced oxidative stress, 3-bromopyruvate and citrate inhibit angiogenesis, exhibiting potent anticancer effects. | Journal of bioenergetics and biomembranes 20121001 |
| Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1. | Cancer research 20120901 |
| Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1. | Journal of pediatric surgery 20120701 |
| Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy. | Surgery today 20120501 |
| 3-Bromopyruvate inhibits calcium uptake by sarcoplasmic reticulum vesicles but not SERCA ATP hydrolysis activity. | The international journal of biochemistry & cell biology 20120501 |
| Casiopeina II-gly and bromo-pyruvate inhibition of tumor hexokinase, glycolysis, and oxidative phosphorylation. | Archives of toxicology 20120501 |
| Aerosolized 3-bromopyruvate inhibits lung tumorigenesis without causing liver toxicity. | Cancer prevention research (Philadelphia, Pa.) 20120501 |
| Mefloquine interferes with glycolysis in schistosomula of Schistosoma mansoni via inhibition of enolase. | Parasitology 20120401 |
| Mitochondrial genome-knockout cells demonstrate a dual mechanism of action for the electron transport complex I inhibitor mycothiazole. | Marine drugs 20120401 |
| Science to practice: what do molecular biologic studies in rodent models add to our understanding of interventional oncologic procedures including percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists? | Radiology 20120301 |
| Human hepatocellular carcinoma in a mouse model: assessment of tumor response to percutaneous ablation by using glyceraldehyde-3-phosphate dehydrogenase antagonists. | Radiology 20120301 |
| Effect of glucose availability on glucose transport in bovine mammary epithelial cells. | Animal : an international journal of animal bioscience 20120301 |
| PPARγ contributes to PKM2 and HK2 expression in fatty liver. | Nature communications 20120214 |
| Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. | EMBO molecular medicine 20120201 |
| Up-regulation of hexokinaseII in myeloma cells: targeting myeloma cells with 3-bromopyruvate. | Journal of bioenergetics and biomembranes 20120201 |
| 3-Bromopyruvate: targets and outcomes. | Journal of bioenergetics and biomembranes 20120201 |
| 3-Bromopyruvate antagonizes effects of lactate and pyruvate, synergizes with citrate and exerts novel anti-glioma effects. | Journal of bioenergetics and biomembranes 20120201 |
| Bromopyruvate mediates autophagy and cardiolipin degradation to monolyso-cardiolipin in GL15 glioblastoma cells. | Journal of bioenergetics and biomembranes 20120201 |
| Flow cytometric evaluation of the effects of 3-bromopyruvate (3BP) and dichloracetate (DCA) on THP-1 cells: a multiparameter analysis. | Journal of bioenergetics and biomembranes 20120201 |
| Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase. | Journal of bioenergetics and biomembranes 20120201 |
| Experimental results using 3-bromopyruvate in mesothelioma: in vitro and in vivo studies. | Journal of bioenergetics and biomembranes 20120201 |
| A translational study 'case report' on the small molecule 'energy blocker' 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside. | Journal of bioenergetics and biomembranes 20120201 |
| Targeting aerobic glycolysis: 3-bromopyruvate as a promising anticancer drug. | Journal of bioenergetics and biomembranes 20120201 |
| Enhancement of hexokinase II inhibitor-induced apoptosis in hepatocellular carcinoma cells via augmenting ER stress and anti-angiogenesis by protein disulfide isomerase inhibition. | Journal of bioenergetics and biomembranes 20120201 |
| Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate. | Journal of bioenergetics and biomembranes 20120201 |
| Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-bromopyruvate propyl ester. | Journal of bioenergetics and biomembranes 20120201 |
| Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae. | Journal of bioenergetics and biomembranes 20120201 |
| 3-Bromopyruvate (3BP) a fast acting, promising, powerful, specific, and effective 'small molecule' anti-cancer agent taken from labside to bedside: introduction to a special issue. | Journal of bioenergetics and biomembranes 20120201 |
| D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate. | Cancer gene therapy 20120101 |
| Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. | Cancer research 20120101 |
| Systemic administration of 3-bromopyruvate in treating disseminated aggressive lymphoma. | Translational research : the journal of laboratory and clinical medicine 20120101 |
| Cancer metabolism: current perspectives and future directions. | Cell death & disease 20120101 |
| Clotrimazole preferentially inhibits human breast cancer cell proliferation, viability and glycolysis. | PloS one 20120101 |
| Thyrocyte-specific inactivation of p53 and Pten results in anaplastic thyroid carcinomas faithfully recapitulating human tumors. | Oncotarget 20111201 |
| MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb. | The Journal of biological chemistry 20111104 |
| Mitochondrial dysfunction and effect of antiglycolytic bromopyruvic acid in GL15 glioblastoma cells. | Journal of bioenergetics and biomembranes 20111001 |
| Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. | Oncogene 20110922 |
| Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment. | The Biochemical journal 20110801 |
| Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis. | Acta pharmacologica Sinica 20110701 |
| Metabolism and brain cancer. | Clinics (Sao Paulo, Brazil) 20110601 |
| Novel intraarterial therapy for liver cancer using ethylbromopyruvate dissolved in an iodized oil. | Academic radiology 20110401 |
| Assessment of tumoricidal efficacy and response to treatment with 18F-FDG PET/CT after intraarterial infusion with the antiglycolytic agent 3-bromopyruvate in the VX2 model of liver tumor. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110201 |
| Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis. | The Journal of biological chemistry 20110128 |
| Inhibition of hexokinase leads to neuroprotection against excitotoxicity in organotypic hippocampal slice culture. | Journal of neuroscience research 20110101 |
| The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil. | Journal of translational medicine 20110101 |
| The dynamics of glutathione species and ophthalmate concentrations in plasma from the VX2 rabbit model of secondary liver tumors. | HPB surgery : a world journal of hepatic, pancreatic and biliary surgery 20110101 |
| Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect. | Perspectives in medicinal chemistry 20110101 |
| Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. | Frontiers in physiology 20110101 |
| The metabolic advantage of tumor cells. | Molecular cancer 20110101 |
| Antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer: a review. | International journal of molecular sciences 20110101 |
| Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy. | BMC cancer 20110101 |
| Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. | Frontiers in pharmacology 20110101 |
| Efficient elimination of cancer cells by deoxyglucose-ABT-263/737 combination therapy. | PloS one 20110101 |
| Mitochondrial NAD+-dependent malic enzyme from Anopheles stephensi: a possible novel target for malaria mosquito control. | Malaria journal 20110101 |
| Systematic exploration of synergistic drug pairs. | Molecular systems biology 20110101 |
| Glycolysis inhibition inactivates ABC transporters to restore drug sensitivity in malignant cells. | PloS one 20110101 |
| Lactate produced by glycogenolysis in astrocytes regulates memory processing. | PloS one 20110101 |
| 3-bromopyruvate: a new targeted antiglycolytic agent and a promise for cancer therapy. | Current pharmaceutical biotechnology 20100801 |
| Interventional oncology: new options for interstitial treatments and intravascular approaches: targeting tumor metabolism via a loco-regional approach: a new therapy against liver cancer. | Journal of hepato-biliary-pancreatic sciences 20100701 |
| Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene. | American journal of physiology. Cell physiology 20100601 |
| 3-Bromopyruvate induces necrotic cell death in sensitive melanoma cell lines. | Biochemical and biophysical research communications 20100528 |
| The pyruvic acid analog 3-bromopyruvate interferes with the tetrazolium reagent MTS in the evaluation of cytotoxicity. | Assay and drug development technologies 20100401 |
| Glycolytic enzyme inhibitors affect pancreatic cancer survival by modulating its signaling and energetics. | Anticancer research 20100301 |
| 3-Bromopyruvate induces endoplasmic reticulum stress, overcomes autophagy and causes apoptosis in human HCC cell lines. | Anticancer research 20100301 |
| Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles. | Organic letters 20100205 |
| Cancer as a metabolic disease. | Nutrition & metabolism 20100101 |
| Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. | Molecular cancer 20100101 |
| Analyzing the regulation of metabolic pathways in human breast cancer. | BMC medical genomics 20100101 |
| Role of the mitochondrion in programmed necrosis. | Frontiers in physiology 20100101 |
| Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death. | Anticancer research 20091201 |
| Targets of 3-bromopyruvate, a new, energy depleting, anticancer agent. | Medicinal chemistry (Shariqah (United Arab Emirates)) 20091101 |
| Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. | Cancer 20091015 |
| Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. | Neurotoxicity research 20091001 |
| Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. | Science (New York, N.Y.) 20090918 |
| A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate. | Molecular diversity 20090801 |
| Inhibitive effect of 3-bromopyruvic acid on human breast cancer MCF-7 cells involves cell cycle arrest and apoptotic induction. | Chinese medical journal 20090720 |
| Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate. | Biochimica et biophysica acta 20090501 |
| Mitochondria and energetic depression in cell pathophysiology. | International journal of molecular sciences 20090501 |
| Specificity of the anti-glycolytic activity of 3-bromopyruvate confirmed by FDG uptake in a rat model of breast cancer. | Investigational new drugs 20090401 |
| Hexokinase inhibitor screening based on adenosine 5'-diphosphate determination by electrophoretically mediated microanalysis. | Electrophoresis 20090401 |
| Novel therapy for malignant pleural mesothelioma based on anti-energetic effect: an experimental study using 3-Bromopyruvate on nude mice. | Anticancer research 20090401 |
| Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. | Blood 20090226 |
| Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. | The Biochemical journal 20090201 |
| Hexokinase-2 bound to mitochondria: cancer's stygian link to the 'Warburg Effect' and a pivotal target for effective therapy. | Seminars in cancer biology 20090201 |
| Senescence induction; a possible cancer therapy. | Molecular cancer 20090101 |
| The antitumor effect and hepatotoxicity of a hexokinase II inhibitor 3-bromopyruvate: in vivo investigation of intraarterial administration in a rabbit VX2 hepatoma model. | Korean journal of radiology 20090101 |
| Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells : ROS-mediated cell death by 3-BrPA. | Journal of bioenergetics and biomembranes 20081201 |
| Non-invasive MRI tumor imaging and synergistic anticancer effect of HSP90 inhibitor and glycolysis inhibitor in RIP1-Tag2 transgenic pancreatic tumor model. | Cancer chemotherapy and pharmacology 20081101 |
| Targeting of VX2 rabbit liver tumor by selective delivery of 3-bromopyruvate: a biodistribution and survival study. | The Journal of pharmacology and experimental therapeutics 20081001 |
| Hamster sperm capacitation: role of pyruvate dehydrogenase A and dihydrolipoamide dehydrogenase. | Biology of reproduction 20080801 |
| Strategies for molecular imaging dementia and neurodegenerative diseases. | Neuropsychiatric disease and treatment 20080601 |
| 3-Bromopyruvate as inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs. | Molecular oncology 20080601 |
| Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. | Clinical cancer research : an official journal of the American Association for Cancer Research 20080315 |
| Revealing targeted therapy for human cancer by gene module maps. | Cancer research 20080115 |
| A novel strategy involved in [corrected] anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network. | PloS one 20080101 |
| Development of a new orthotopic animal model of metastatic liver cancer in the rabbit VX2 model: effect on metastases after partial hepatectomy, intra-arterial treatment with 3-bromopyruvate and chemoembolization. | Clinical & experimental metastasis 20080101 |
| Systems biology approach to identification of biomarkers for metastatic progression in cancer. | BMC bioinformatics 20080101 |
| Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20071101 |
| Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma. | Molecular cancer therapeutics 20070901 |
| Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the 'Warburg Effect', i.e., elevated glycolysis in the presence of oxygen. | Journal of bioenergetics and biomembranes 20070601 |
| [Expression of hexokinase-II gene in human colon cancer cells and the therapeutic significance of inhibition thereof]. | Zhonghua yi xue za zhi 20070417 |
| The cancer cell's 'power plants' as promising therapeutic targets: an overview. | Journal of bioenergetics and biomembranes 20070201 |
| Local toxicity of hepatic arterial infusion of hexokinase II inhibitor, 3-bromopyruvate: In vivo investigation in normal rabbit model. | Academic radiology 20070101 |
| Intraarterial therapy with a new potent inhibitor of tumor metabolism (3-bromopyruvate): identification of therapeutic dose and method of injection in an animal model of liver cancer. | Journal of vascular and interventional radiology : JVIR 20070101 |
| FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model. | Korean journal of radiology 20070101 |
| The oncoprotein H-RasV12 increases mitochondrial metabolism. | Molecular cancer 20070101 |
| The role of glucose metabolism and glucose-associated signalling in cancer. | Perspectives in medicinal chemistry 20070101 |
| Hepatic intra-arterial injection of 3-bromopyruvate in rabbit VX2 tumor. | Acta radiologica (Stockholm, Sweden : 1987) 20061201 |
| Colony-stimulating factor-1 requires PI3-kinase-mediated metabolism for proliferation and survival in myeloid cells. | Cell death and differentiation 20061101 |
| Inactivation of H+-vacuolar ATPase by the energy blocker 3-bromopyruvate, a new antitumour agent. | Life sciences 20061019 |
| Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. | Oncogene 20060807 |
| Synthesis of functionalized 5-imino-2,5-dihydro-furans through the reaction of isocyanides with activated acetylenes in the presence of ethyl bromopyruvate. | Molecular diversity 20060801 |
| Hypoxia stimulates proliferation of human hepatoma cells through the induction of hexokinase II expression. | Journal of hepatology 20050301 |
| Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. | Cancer research 20050115 |
| Targeting energy metabolism in brain cancer: review and hypothesis. | Nutrition & metabolism 20050101 |
| Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP. | Biochemical and biophysical research communications 20041105 |
| Flux to acetate and lactate excretions in industrial fermentations: physiological and biochemical implications. | Journal of industrial microbiology & biotechnology 20040801 |
| Carbonic anhydrase in mammalian vascular smooth muscle. | The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20040801 |
| Recently elucidated energy catabolism pathways provide opportunities for novel treatments in hepatocellular carcinoma. | Expert review of anticancer therapy 20040601 |
| Crystal structure of 2-methylisocitrate lyase (PrpB) from Escherichia coli and modelling of its ligand bound active centre. | Journal of molecular biology 20030502 |
| Glycolytic ATP production regulates muscarinic cation currents in guinea-pig ileum. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20030401 |
| A new approach to therapy for hepatocellular carcinoma? | Hepatology (Baltimore, Md.) 20030201 |
| Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis. | The Journal of biological chemistry 20030117 |
| Energy blocker to treat liver cancer. | Drug discovery today 20020915 |
| 3-Bromopyruvate kills cancer cells in animals. | The Lancet. Oncology 20020901 |
| Novel therapy for liver cancer: direct intraarterial injection of a potent inhibitor of ATP production. | Cancer research 20020715 |
| Lack of antifertility properties of novel halogenated glycolytic inhibitors and the urinary excretion and metabolism of 1,6-dichloro-1,6-dideoxy-D-fructofuranose in the male rat. | International journal of andrology 20020601 |
| An absolute requirement of fructose 1,6-bisphosphate for the Lactobacillus casei L-lactate dehydrogenase activity induced by a single amino acid substitution. | Protein engineering 20020101 |
| Investigation of red blood cell carbonic anhydrase, glucose 6-phosphate dehydrogenase, hexokinase enzyme activities, and zinc concentration in patients with hyperthyroid diseases. | Endocrine research 20020101 |
| Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. | Cancer letters 20011108 |
| Modification of human erythrocyte pyruvate kinase by an active site-directed reagent: bromopyruvate. | Journal of enzyme inhibition 20011101 |
| 2-Methylisocitrate lyases from the bacterium Escherichia coli and the filamentous fungus Aspergillus nidulans: characterization and comparison of both enzymes. | European journal of biochemistry 20010601 |
| Alkylation of isocitrate lyase from Escherichia coli by 3-bromopyruvate. | Archives of biochemistry and biophysics 19900501 |
| Chemical modifications of Serratia marcescens anthranilate synthase component I. | The Journal of biological chemistry 19811010 |
| Equilibrium substrate binding studies of the malic enzyme of pigeon liver. Equivalence of nucleotide sites and anticooperativity associated with the binding of L-malate to the enzyme-manganese(II)-reduced nicotinamide adenine dinucleotide phosphate ternary complex. | Biochemistry 19800304 |