Triptolide disrupts the actin-based Sertoli-germ cells adherens junctions by inhibiting Rho GTPases expression.

Toxicology and applied pharmacology 20161101

Protection of Quercetin against Triptolide-induced apoptosis by suppressing oxidative stress in rat Leydig cells.

Chemico-biological interactions 20151005

Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC-MS based metabolomics study.

Toxicology 20151002

Inhibition of P-glycoprotein Gene Expression and Function Enhances Triptolide-induced Hepatotoxicity in Mice.

Scientific reports 20150101

Triptolide-induced oxidative stress involved with Nrf2 contribute to cardiomyocyte apoptosis through mitochondrial dependent pathways.

Toxicology letters 20141104

Interleukin-17 mediates triptolide-induced liver injury in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140901

Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.

Journal of applied toxicology : JAT 20140801

Establishment of hypoxia induction in an in vivo animal replacement model for experimental evaluation of pancreatic cancer.

Oncology reports 20140701

FSL-1 induces MMP-9 production through TLR-2 and NF-κB /AP-1 signaling pathways in monocytic THP-1 cells.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20140101

Gene expression profiling and pathway analysis of hepatotoxicity induced by triptolide in Wistar rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20130801

Identification of potent Yes1 kinase inhibitors using a library screening approach.

Bioorganic & medicinal chemistry letters 20130801

NF-κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model.

International journal of cancer 20121115

Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20121101

Anti-inflammatory effects of mapracorat, a novel selective glucocorticoid receptor agonist, is partially mediated by MAP kinase phosphatase-1 (MKP-1).

The Journal of biological chemistry 20121012

Triptolide modulates the sensitivity of K562/A02 cells to adriamycin by regulating miR-21 expression.

Pharmaceutical biology 20121001

Biological activity and safety of Tripterygium extract prepared by sodium carbonate extraction.

Molecules (Basel, Switzerland) 20120917

Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells.

Toxicology letters 20120903

Triptolide in the treatment of psoriasis and other immune-mediated inflammatory diseases.

British journal of clinical pharmacology 20120901

Triptolide triggers the apoptosis of pancreatic cancer cells via the downregulation of Decoy receptor 3 expression.

Journal of cancer research and clinical oncology 20120901

Triptolide regulates T cell-mediated immunity via induction of CD11c(low) dendritic cell differentiation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120701

In vitro and in vivo evaluation of Triptolide-loaded pluronic P105 polymeric micelles.

Arzneimittel-Forschung 20120701

Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo.

Cancer letters 20120628

Triptolide inhibits colon cancer cell proliferation and induces cleavage and translocation of 14-3-3 epsilon.

Cell biochemistry and function 20120601

Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model.

International immunopharmacology 20120601

Effect of triptolide on T-cell receptor beta variable gene mRNA expression in rats with collagen-induced arthritis.

Anatomical record (Hoboken, N.J. : 2007) 20120601

Effect of triptolide on progesterone production from cultured rat granulosa cells.

Arzneimittel-Forschung 20120601

Activation of apoptosis signaling eliminates CD34+ progenitor cells in blast crisis CML independent of response to tyrosine kinase inhibitors.

Leukemia 20120401

MKP-1: a negative feedback effector that represses MAPK-mediated pro-inflammatory signaling pathways and cytokine secretion in human airway smooth muscle cells.

Cellular signalling 20120401

Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms.

Natural product reports 20120401

[Effects of triptolide on bortezomib-induced apoptosis in multiple myeloma cells].

Zhongguo shi yan xue ye xue za zhi 20120401

Triptolide down-regulates COX-2 expression and PGE2 release by suppressing the activity of NF-κB and MAP kinases in lipopolysaccharide-treated PC12 cells.

Phytotherapy research : PTR 20120301

Triptolide attenuate the oxidative stress induced by LPS/D-GalN in mice.

Journal of cellular biochemistry 20120301

Intrathecal administration of triptolide, a T lymphocyte inhibitor, attenuates chronic constriction injury-induced neuropathic pain in rats.

Brain research 20120203

[Effect of triptolide on sensitivity of K562/A02 cell line to adriamycin].

Zhongguo shi yan xue ye xue za zhi 20120201

[Triptolide combined with irbesartan synergistically blocks podocyte injury in a type 2 diabetes rat model].

Zhonghua nei ke za zhi 20120201

Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model.

Cancer chemotherapy and pharmacology 20120101

Local suppression of pro-inflammatory cytokines and the effects in BMP-2-induced bone regeneration.

Biomaterials 20120101

Triptolide induces cell-cycle arrest and apoptosis of human multiple myeloma cells in vitro via altering expression of histone demethylase LSD1 and JMJD2B.

Acta pharmacologica Sinica 20120101

Effect of triptolide on estradiol release from cultured rat granulosa cells.

Endocrine journal 20120101

Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.

PloS one 20120101

Triptolide inhibits the proliferation of prostate cancer cells and down-regulates SUMO-specific protease 1 expression.

PloS one 20120101

Disseminated cutaneous Kaposi sarcoma in a patient receiving triptolide/tripdiolide for rheumatoid arthritis.

Medical science monitor : international medical journal of experimental and clinical research 20120101

Prediction of the pharmacokinetic parameters of triptolide in rats based on endogenous molecules in pre-dose baseline serum.

PloS one 20120101

Triptolide inhibits COX-2 expression by regulating mRNA stability in TNF-α-treated A549 cells.

Biochemical and biophysical research communications 20111209

Complexation of triptolide and its succinate derivative with cyclodextrins: affinity capillary electrophoresis, isothermal titration calorimetry and 1H NMR studies.

Journal of chromatography. A 20111202

Cytotoxicity of Triptolide and Triptolide loaded polymeric micelles in vitro.

Toxicology in vitro : an international journal published in association with BIBRA 20111201

Inhibition of mitochondrial respiratory chain is involved in triptolide-induced liver injury.

Fitoterapia 20111201

Triptolide inhibits IFN-γ signaling via the Jak/STAT pathway in HaCaT keratinocytes.

Phytotherapy research : PTR 20111101

Effect of triptolide on focal adhesion kinase and survival in MCF-7 breast cancer cells.

Oncology reports 20111101

Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.

Biochemical pharmacology 20111101

Metabolite identification of triptolide by data-dependent accurate mass spectrometric analysis in combination with online hydrogen/deuterium exchange and multiple data-mining techniques.

Rapid communications in mass spectrometry : RCM 20111030

Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production.

International immunopharmacology 20111001

Knockout of hepatic P450 reductase aggravates triptolide-induced toxicity.

Toxicology letters 20110810

A high-sensitivity UPLC-MS/MS method for simultaneous determination and confirmation of triptolide in zebrafish embryos.

Biomedical chromatography : BMC 20110801

Triptolide directly inhibits dCTP pyrophosphatase.

Chembiochem : a European journal of chemical biology 20110725

Antifibrotic effects of triptolide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.

Phytotherapy research : PTR 20110701

Clinical outcomes in children with Henoch-Schönlein purpura nephritis grade IIIa or IIIb.

Pediatric nephrology (Berlin, Germany) 20110701

Does triptolide induce lysosomal-mediated apoptosis in human breast cancer cells?

Medical hypotheses 20110701

The main anticancer bullets of the Chinese medicinal herb, thunder god vine.

Molecules (Basel, Switzerland) 20110623

Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors.

The Journal of surgical research 20110615

Triptolide ameliorates Crohn's colitis is associated with inhibition of TLRs/NF-κB signaling pathway.

Fitoterapia 20110601

Role of reactive oxygen species in triptolide-induced apoptosis of renal tubular cells and renal injury in rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110601

Inhibitive effect of triptolide on invasiveness of human fibrosarcoma cells by downregulating matrix metalloproteinase-9 expression.

Asian Pacific journal of tropical medicine 20110601

[Modulatory effect of triptolide on differentiation of human Th17 cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110601

Semisynthesis of triptolide analogues: effect of γ-lactone and C-14 substituents on cytotoxic activities.

Bioorganic & medicinal chemistry letters 20110515

CD40-modulated dual-specificity phosphatases MAPK phosphatase (MKP)-1 and MKP-3 reciprocally regulate Leishmania major infection.

Journal of immunology (Baltimore, Md. : 1950) 20110515

Total synthesis of novel D-ring-modified triptolide analogues: structure-cytotoxic activity relationship studies on the D-ring of triptolide.

Organic & biomolecular chemistry 20110507

Triptolide inhibits rat vascular smooth muscle cell proliferation and cell cycle progression via attenuation of ERK1/2 and Rb phosphorylation.

Experimental and molecular pathology 20110401

Triptolide alleviates hepatic ischemia/reperfusion injury by attenuating oxidative stress and inhibiting NF-κB activity in mice.

The Journal of surgical research 20110401

Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells.

Oncology reports 20110401

Effectiveness of triptolide-coated stent on decreasing inflammation and attenuation of intimal hyperplasia in a pig after coronary angioplasty.

Angiology 20110401

Triptolide inhibits the proliferation of cells from lymphocytic leukemic cell lines in association with downregulation of NF-κB activity and miR-16-1*.

Acta pharmacologica Sinica 20110401

Derivatization of (5R)-hydroxytriptolide from benzylamine to enhance mass spectrometric detection: application to a Phase I pharmacokinetic study in humans.

Analytica chimica acta 20110309

The effects of triptolide on airway remodelling and transforming growth factor-β₁/Smad signalling pathway in ovalbumin-sensitized mice.

Immunology 20110301

Triptolide and its expanding multiple pharmacological functions.

International immunopharmacology 20110301

XPB, a subunit of TFIIH, is a target of the natural product triptolide.

Nature chemical biology 20110301

Biologic activity of triptolide in t(8;21) acute myeloid leukemia cells.

Leukemia research 20110201

Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway.

Oncology reports 20110201

Triptolide attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction.

Nephrology (Carlton, Vic.) 20110201

MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status.

Planta medica 20110101

Triptolide induces adverse effect on reproductive parameters of female Sprague-Dawley rats.

Drug and chemical toxicology 20110101

Therapeutic approach to multiple sclerosis by novel oral drug.

Recent patents on inflammation & allergy drug discovery 20110101

In vitro synergistic cytotoxic effect of triptolide combined with hydroxycamptothecin on pancreatic cancer cells.

The American journal of Chinese medicine 20110101

Inhibition of tumor cellular proteasome activity by triptolide extracted from the Chinese medicinal plant 'thunder god vine'.

Anticancer research 20110101

Inhibition of poly(I:C)-induced matrix metalloproteinase expression in human corneal fibroblasts by triptolide.

Molecular vision 20110101

Disappearance of sexual dimorphism in triptolide metabolism in monosodium glutamate treated neonatal rats.

Arzneimittel-Forschung 20110101

[Pharmacokinetics of triptolide in Triptergium wilfordii microemulsion gel].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110101

Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).

PloS one 20110101

Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells.

Arzneimittel-Forschung 20110101

Triptolide downregulates human GD3 synthase (hST8Sia I) gene expression in SK-MEL-2 human melanoma cells.

Experimental & molecular medicine 20101231

Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model.

Journal of liposome research 20101201

Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.

Cancer letters 20101128

Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells.

European journal of pharmacology 20101110

Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101101

Transcription factor NF-κB inhibitors as single therapeutic agents or in combination with classical chemotherapeutic agents for the treatment of hematologic malignancies.

Current molecular pharmacology 20101101

Synthesis and biological evaluation of novel triptolide analogues for anticancer activity.

Bioorganic & medicinal chemistry letters 20101101

Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Bioorganic & medicinal chemistry letters 20101101

Triptolide inactivates Akt and induces caspase-dependent death in cervical cancer cells via the mitochondrial pathway.

International journal of oncology 20101101

Triptolide inhibits extracellular matrix protein synthesis by suppressing the Smad2 but not the MAPK pathway in TGF-beta1-stimulated NRK-49F cells.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101001

Physio-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells.

Toxicology in vitro : an international journal published in association with BIBRA 20101001

Triptolide and TRAIL combination enhances apoptosis in cholangiocarcinoma.

The Journal of surgical research 20101001

Autophagy in pancreatic cancer: an emerging mechanism of cell death.

Autophagy 20101001

Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17.

Molecular immunology 20100901

Role of Hsp-70 in triptolide-mediated cell death of neuroblastoma.

The Journal of surgical research 20100901

Diastereoselective formal total synthesis of (+/-)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane.

Chemical communications (Cambridge, England) 20100821

Triptolide T10 enhances AAV-mediated gene transfer in mice striatum.

Neuroscience letters 20100802

Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways.

Gastroenterology 20100801

[Effect of triptolide on reversing hypermethylation of apc gene in Jurkat cells and its possible mechanisms].

Zhongguo shi yan xue ye xue za zhi 20100801

[Effects of triptolide on hypothalamic-pituitary-adrenal axis of rats].

Fa yi xue za zhi 20100801

Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100701

RNA polymerase - an important molecular target of triptolide in cancer cells.

Cancer letters 20100628

Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells.

Anti-cancer drugs 20100601

Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation.

Glia 20100601

Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation.

American journal of physiology. Lung cellular and molecular physiology 20100601

Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro.

Kidney international 20100601

Effects of triptolide on RIZ1 expression, proliferation, and apoptosis in multiple myeloma U266 cells.

Acta pharmacologica Sinica 20100601

Triptolide prolonged allogeneic islet graft survival in chemically induced and spontaneously diabetic mice without impairment of islet function.

Hepatobiliary & pancreatic diseases international : HBPD INT 20100601

[Effects of triptolide-medicated serum on secretion function of adrenocortical cells isolated from rats].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20100601

Triptolide simultaneously induces reactive oxygen species, inhibits NF-kappaB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines.

Cancer letters 20100528

Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1.

Cancer letters 20100528

Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats.

Toxicology 20100430

Novel anti-inflammatory and neuroprotective agents for Parkinson's disease.

CNS & neurological disorders drug targets 20100401

Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.

Journal of immunology (Baltimore, Md. : 1950) 20100401

[Effects of triptolide on cell proliferation and regulation of Ras-MAPKs pathway in synoviocytes induced by tumor necrosis factor].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl.

Bioorganic & medicinal chemistry 20100301

Merging traditional Chinese medicine with modern drug discovery technologies to find novel drugs and functional foods.

Current drug discovery technologies 20100301

Targeting tumor proteasome with traditional Chinese medicine.

Current drug discovery technologies 20100301

Induction of dual specificity phosphatase 1 (DUSP1) by gonadotropin-releasing hormone (GnRH) and the role for gonadotropin subunit gene expression in mouse pituitary gonadotroph L beta T2 cells.

Biology of reproduction 20100201

Effects of cytochrome P4503A inducer dexamethasone on the metabolism and toxicity of triptolide in rat.

Toxicology letters 20100201

TRAIL and triptolide: an effective combination that induces apoptosis in pancreatic cancer cells.

Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20100201

[Research progress on immunosuppressive activity of monomers extracted from Chinese medicine].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100201

Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro.

Toxicology 20100112

A facile construction strategy of stable lipid nanoparticles for drug delivery using a hydrogel-thickened microemulsion system.

Nanotechnology 20100108

Triptolide functions as a potent angiogenesis inhibitor.

International journal of cancer 20100101

Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells.

Vascular pharmacology 20100101

Programmed cell death 5 factor enhances triptolide-induced fibroblast-like synoviocyte apoptosis of rheumatoid arthritis.

Artificial cells, blood substitutes, and immobilization biotechnology 20100101

Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide.

Molecular cancer 20100101

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.

Journal of neuroimmunology 20091210

Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70.

Journal of neuroimmunology 20091210

Identification of inhibitors of HSF1 functional activity by high-content target-based screening.

Journal of biomolecular screening 20091201

Triptolide induces apoptosis in human anaplastic thyroid carcinoma cells by a p53-independent but NF-kappaB-related mechanism.

Oncology reports 20091201

Effects of triptolide from Tripterygium wilfordii on ERalpha and p53 expression in two human breast cancer cell lines.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20091101

Triptolide abrogates oncogene FIP1L1-PDGFRalpha addiction and induces apoptosis in hypereosinophilic syndrome.

Cancer science 20091101

Ancient drugs, modern targets.

Cancer biology & therapy 20091101

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells.

Cancer biology & therapy 20091101

Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression.

Experimental & molecular medicine 20091031

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA.

Molecular cancer therapeutics 20091001

Triptolide-induced suppression of phospholipase D expression inhibits proliferation of MDA-MB-231 breast cancer cells.

Experimental & molecular medicine 20090930

Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells.

Molecular cancer therapeutics 20090901

Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents.

Journal of medicinal chemistry 20090827

Triptolide promotes generation of FoxP3+ T regulatory cells in rats.

Journal of ethnopharmacology 20090817

Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo.

Surgery 20090801

[Advance in the anti-tumor mechanism of triptolide].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090801

Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo.

Oral oncology 20090701

Activity of triptolide against human mast cells harboring the kinase domain mutant KIT.

Cancer science 20090701

[Effect of triptolide on the proliferation and apoptosis of human epidermal squamous cell carcinoma cell line A431 in vitro].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090701

[Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090701

Caspase 3 is involved in the apoptosis induced by triptolide in HK-2 cells.

Toxicology in vitro : an international journal published in association with BIBRA 20090601

Possible involvement of mitogen-activated protein kinase phosphatase-1 (MKP-1) in thyrotropin-releasing hormone (TRH)-induced prolactin gene expression.

Biochemical and biophysical research communications 20090515

Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine.

Journal of chromatography. A 20090508

Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms.

Gastroenterology 20090501

Interleukin-6-independent expression of glucocorticoid receptor is upregulated by triptolide in multiple myeloma.

Leukemia & lymphoma 20090501

Overcoming glucocorticoid resistance: a new pathway from an ancient Chinese medicine?

Leukemia & lymphoma 20090501

Clinical applications of the immunomodulatory properties of triptolide besides in arthritis.

Scandinavian journal of immunology 20090501

A small-molecule triptolide suppresses angiogenesis and invasion of human anaplastic thyroid carcinoma cells via down-regulation of the nuclear factor-kappa B pathway.

Molecular pharmacology 20090401

Inhibiting the transcription factor HSF1 as an anticancer strategy.

Expert opinion on therapeutic targets 20090401

Simultaneous determination of triptolide, tripdiolide and tripterine in human urine by high-performance liquid chromatography coupled with ion trap atmospheric-pressure chemical ionization mass spectrometry.

Biomedical chromatography : BMC 20090301

The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells.

Biomaterials 20090301

Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation.

Clinical cancer research : an official journal of the American Association for Cancer Research 20090301

[Suppression of murine EAE by triptolide is related to downregulation of INF-gamma and upregulation of IL-10 secretion in splenic lymphocytes].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20090301

[Cordyceps sinensis polysaccharide enhances apoptosis of HL-60 cells induced by triptolide].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20090301

[Triptolide evaluates DNA methylation level of matrix metalloproteinase 9 gene in human fibrosarcoma HT-1080 cells].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301

Triptolide and management of systemic malignancies besides pancreatic carcinomas.

World journal of gastroenterology 20090227

Antiangiogenic activity of Tripterygium wilfordii and its terpenoids.

Journal of ethnopharmacology 20090112

Heat shock protein 72 protects kidney proximal tubule cells from injury induced by triptolide by means of activation of the MEK/ERK pathway.

International journal of toxicology 20090101

The effect of triptolide on CD4+ and CD8+ cells in the Peyer's patch of DA rats with collagen induced arthritis.

Natural product research 20090101

Therapeutic effects of triptolide on interleukin-10 gene-deficient mice with colitis.

International immunopharmacology 20081220

[Overexpression of programmed cell death 5 factor enhances triptolides-induced fibroblast-like synoviocytes apoptosis in rheumatoid arthritis].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20081218

Triptolide inhibits amyloid-beta1-42-induced TNF-alpha and IL-1beta production in cultured rat microglia.

Journal of neuroimmunology 20081215

Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies.

Journal of chromatography. A 20081212

Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells.

Experimental hematology 20081201

In vivo evaluation of the safety of triptolide-loaded hydrogel-thickened microemulsion.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

Characterization of triptolide hydroxylation by cytochrome P450 in human and rat liver microsomes.

Xenobiotica; the fate of foreign compounds in biological systems 20081201

Prolongation of rat intestinal allograft survival by administration of triptolide-modified donor bone marrow-derived dendritic cells.

Transplantation proceedings 20081201

[Advances in the study of immunopharmacological effects and mechanisms of extracts of Tripterygium wilfordii Hook. f. in neuroimmunologic disorders].

Yao xue xue bao = Acta pharmaceutica Sinica 20081201

Triptolide inhibits interferon-gamma-induced programmed death-1-ligand 1 surface expression in breast cancer cells.

Cancer letters 20081108

The suppressive effect of triptolide on chronic colitis and TNF-alpha/TNFR2 signal pathway in interleukin-10 deficient mice.

Clinical immunology (Orlando, Fla.) 20081101

Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20081101

Triptolide inhibits COX-2 expression and PGE2 release by suppressing the activity of NF-kappaB and JNK in LPS-treated microglia.

Journal of neurochemistry 20081101

Therapeutic strategies for Parkinson's disease: the ancient meets the future--traditional Chinese herbal medicine, electroacupuncture, gene therapy and stem cells.

Neurochemical research 20081001

Triptolide inhibits the differentiation of Th17 cells and suppresses collagen-induced arthritis.

Scandinavian journal of immunology 20081001

Triptolide overcomes dexamethasone resistance and enhanced PS-341-induced apoptosis via PI3k/Akt/NF-kappaB pathways in human multiple myeloma cells.

International journal of molecular medicine 20081001

Triptolide protects podocytes from puromycin aminonucleoside induced injury in vivo and in vitro.

Kidney international 20080901

Triptolide reduces cystogenesis in a model of ADPKD.

Journal of the American Society of Nephrology : JASN 20080901

Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis.

Journal of neuroscience research 20080815

Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3beta with p53.

Oncogene 20080731

Differential effects of triptolide and tetrandrine on activation of COX-2, NF-kappaB, and AP-1 and virus production in dengue virus-infected human lung cells.

European journal of pharmacology 20080728

Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesis.

International immunopharmacology 20080701

Triptolide-induced transcriptional arrest is associated with changes in nuclear substructure.

Cancer research 20080701

Effect of poly(D, L-lactic acid) nanoparticles as triptolide carrier on abating rats renal toxicity by NMR-based metabolic analysis.

Journal of nanoscience and nanotechnology 20080701

Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: implication for immunosuppressive therapy in Parkinson's disease.

Neuroscience bulletin 20080601

Effective therapy for nephritis in (NZB x NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedy Tripterygium wilfordii Hook F.

Arthritis and rheumatism 20080601

Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080601

[Effects of triptolide on proliferation and apoptosis of Jurkat cell line in acute T lymphocytic leukemia].

Zhongguo shi yan xue ye xue za zhi 20080601

Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation.

Transplant international : official journal of the European Society for Organ Transplantation 20080501

Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5.

Blood 20080401

Fluorination of triptolide and its analogues and their cytotoxicity.

Bioorganic & medicinal chemistry letters 20080401

Involvement of mitochondrial pathway in triptolide-induced cytotoxicity in human normal liver L-02 cells.

Biological & pharmaceutical bulletin 20080401

Formal total synthesis of triptolide.

Chemical communications (Cambridge, England) 20080314

Apoptosis of human pancreatic cancer cells induced by Triptolide.

World journal of gastroenterology 20080314

[The cornea: stasis and dynamics].

Nippon Ganka Gakkai zasshi 20080301

Upregulation of ICAM-1 expression in bronchial epithelial cells by airway secretions in bronchiectasis.

Respiratory medicine 20080201

Immunochemical characterization of the functional constituents of Tripterygium wilfordii contributing to its anti-inflammatory property.

Clinical and experimental pharmacology & physiology 20080101

Role of triptolide as an adjunct chemotherapy for ovarian cancer.

Chemotherapy 20080101

[Male antifertility drugs and cell apoptosis].

Zhonghua nan ke xue = National journal of andrology 20080101

Development and validation of a liquid chromatography coupled with atmospheric-pressure chemical ionization ion trap mass spectrometric method for the simultaneous determination of triptolide, tripdiolide, and tripterine in human serum.

Journal of analytical toxicology 20080101

Male reproductive toxicity and toxicokinetics of triptolide in rats.

Arzneimittel-Forschung 20080101

Triptolide, a component of Chinese herbal medicine, modulates the functional phenotype of dendritic cells.

Transplantation 20071215

Triptolide inhibits NF-kappaB activation and reduces injury of donor lung induced by ischemia/reperfusion.

Acta pharmacologica Sinica 20071201

Honeybee (Apis cerana) foraging responses to the toxic honey of Tripterygium hypoglaucum (Celastraceae): changing threshold of nectar acceptability.

Journal of chemical ecology 20071201

Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70.

Cancer research 20071001

[Effect of triptolide on the expression of matrix metalloproteinases 2 and 9 in lungs of experimental pulmonary hypertension].

Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20071001

Molecular understanding and modern application of traditional medicines: triumphs and trials.

Cell 20070907

Differential expression and oxidation of MKP-1 modulates TNF-alpha gene expression.

American journal of respiratory cell and molecular biology 20070901

Experimental AA amyloidosis in mice is inhibited by treatment with triptolide, a purified traditional Chinese medicine.

International immunopharmacology 20070901

[Effect of triptolide on the development of monocrotaline-induced pulmonary hypertension in pneumonectomized rat].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070901

Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration.

International journal of pharmaceutics 20070816

Enhanced antitumor effect of combined triptolide and ionizing radiation.

Clinical cancer research : an official journal of the American Association for Cancer Research 20070815

Involvement of PDCD5 in the regulation of apoptosis in fibroblast-like synoviocytes of rheumatoid arthritis.

Apoptosis : an international journal on programmed cell death 20070801

[Effect of triptolide on airway remodeling and the expression of phosphoinositide 3-kinases in asthmatic rats].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801

Gene expression profile analyses of mice livers injured by Leigongteng.

World journal of gastroenterology 20070714

Kinetic release of triptolide after injection of renal-targeting 14-succinyl triptolide-lysozyme in a rat kidney study by liquid chromatography/mass spectrometry.

Biomedical chromatography : BMC 20070701

Triptolide upregulates NGF synthesis in rat astrocyte cultures.

Neurochemical research 20070701

Suppression of 5-lipoxygenase gene is involved in triptolide-induced apoptosis in pancreatic tumor cell lines.

Biochimica et biophysica acta 20070701

Triptolide suppresses interleukin-1beta-induced human beta-defensin-2 mRNA expression through inhibition of transcriptional activation of NF-kappaB in A549 cells.

International journal of molecular medicine 20070501

Synergistic effect of triptolide combined with 5-fluorouracil on colon carcinoma.

Postgraduate medical journal 20070501

[Triptolide-eluting stent prevents porcine coronary artery in-stent restenosis by affecting PCNA and P27(kip1) expression].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501

Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways.

Molecular immunology 20070401

Therapeutic effect of combined triptolide and glycyrrhizin treatment on rats with collagen induced arthritis.

Planta medica 20070401

Anti-inflammatory and immunosuppressive compounds from Tripterygium wilfordii.

Phytochemistry 20070401

Pharmacokinetic study of triptolide, a constituent of immunosuppressive chinese herb medicine, in rats.

Biological & pharmaceutical bulletin 20070401

[Effects of triptolide on the production of interferon-gamma in human peripheral blood mononuclear cell and phosphorylation of signal transducer and activator of transcription-1 and production of interleukin-8].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20070401

[Microstructure of novel solid lipid nanoparticle loaded triptolide].

Yao xue xue bao = Acta pharmaceutica Sinica 20070401

Herbal diterpenoids induce growth arrest and apoptosis in colon cancer cells with increased expression of the nonsteroidal anti-inflammatory drug-activated gene.

European journal of pharmacology 20070315

Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae).

Phytochemistry 20070301

[Effects of triptolide on prostate carcinoma in mouse RM-1 cells].

Zhonghua nan ke xue = National journal of andrology 20070301

[Effect of combination glycyrrhiizin and triptolide on TNF-alpha and IL-10 in serum of collagen induced arthritis rats].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

Triptolide inhibits cyclooxygenase-2 and inducible nitric oxide synthase expression in human colon cancer and leukemia cells.

Acta biochimica et biophysica Sinica 20070201

Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice.

Biochemical pharmacology 20070101

The roles of endogenous reactive oxygen species and nitric oxide in triptolide-induced apoptotic cell death in macrophages.

Journal of molecular medicine (Berlin, Germany) 20070101

Triptolide suppresses IL-1beta-induced chemokine and stromelysin-1 gene expression in human colonic subepithelial myofibroblasts.

Acta pharmacologica Sinica 20070101

[Pharmacokinetics of triptolide in Beagle dogs].

Yao xue xue bao = Acta pharmaceutica Sinica 20070101

Triptolide binds covalently to a 90 kDa nuclear protein. Role of epoxides in binding and activity.

Immunobiology 20070101

Inhibitory effect of triptolide on glioblastoma multiforme in vitro.

The Journal of international medical research 20070101

Triptolide alters mitochondrial functions.

Advances in experimental medicine and biology 20070101

The effect of triptolide on apoptosis of glioblastoma multiforme (GBM) cells.

The Journal of international medical research 20070101

Triptolide inhibits tumor promoter-induced uPAR expression via blocking NF-kappaB signaling in human gastric AGS cells.

Anticancer research 20070101

Triptolide inhibits CCR5 expressed in synovial tissue of rat adjuvant-induced arthritis.

Pharmacological reports : PR 20070101

Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis.

International immunopharmacology 20061205

Synthesis, characterization and in vitro evaluation of triptolide-lysozyme conjugate for renal targeting delivery of triptolide.

Archives of pharmacal research 20061201

[Study on content variation of triptolide in medicinal material of Tripterygium].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

Inhibitory effect of triptolide on lymph node metastasis in patients with non-Hodgkin lymphoma by regulating SDF-1/CXCR4 axis in vitro.

Acta pharmacologica Sinica 20061101

Effects of triptolide and TNF-alpha on the expression of VEGF in Raji cells and on angiogenesis in ECV304 cells.

Zhongguo shi yan xue ye xue za zhi 20061001

[Correlations between diagnostic information and therapeutic efficacy in rheumatoid arthritis analyzed with decision tree model].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20061001

[Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061001

Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells.

Cancer letters 20060908

Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts.

Investigative ophthalmology & visual science 20060901

[Protective effects of triptolide on the lipopolysaccharide-mediated degeneration of dopaminergic neurons in substantia nigra].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060801

Dipyridamole activation of mitogen-activated protein kinase phosphatase-1 mediates inhibition of lipopolysaccharide-induced cyclooxygenase-2 expression in RAW 264.7 cells.

European journal of pharmacology 20060717

Triptolide induces caspase-dependent cell death mediated via the mitochondrial pathway in leukemic cells.

Blood 20060715

Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation.

Biochemical and biophysical research communications 20060707

Triptolide inhibits COX-2 expression via NF-kappa B pathway in astrocytes.

Neuroscience research 20060601

(5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide derivative, prevents experimental autoimmune encephalomyelitis via inhibiting T cell activation.

Journal of neuroimmunology 20060601

Liquid chromatographic/mass spectrometry assay of triptolide in dog plasma and its application to pharmacokinetic study.

Journal of pharmaceutical and biomedical analysis 20060503

Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.

Journal of molecular medicine (Berlin, Germany) 20060501

Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death.

The Journal of biological chemistry 20060407

Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.

Bioorganic & medicinal chemistry letters 20060401

Inhibitory effects of Triptolide on interferon-gamma-induced human leucocyte antigen-DR, intercellular adhesion molecule-1, CD40 expression on retro-ocular fibroblasts derived from patients with Graves' ophthalmopathy.

Clinical & experimental ophthalmology 20060401

Triptolide inhibits B7-H1 expression on proinflammatory factor activated renal tubular epithelial cells by decreasing NF-kappaB transcription.

Molecular immunology 20060301

The effect of triptolide on CD4+ and CD8+ cells in Peyer's patch of SD rats with collagen induced arthritis.

International immunopharmacology 20060201

Triptolide attenuates oxidative stress, NF-kappaB activation and multiple cytokine gene expression in murine peritoneal macrophage.

International journal of molecular medicine 20060101

Triptolide sensitizes resistant cholangiocarcinoma cells to TRAIL-induced apoptosis.

Anticancer research 20060101

A novel method to convert triptolide into tripchlorolide in Tripterygium wilfordii.

Phytochemical analysis : PCA 20060101

Effect of triptolide on expression of receptor activator of nuclear factor-kappaB ligand in rat adjuvant induced arthritis.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

Relationship between single nucleotide polymorphism in TNF-alpha gene promoter region and inhibitory effects of triptolide on TNF-alpha production in peripheral blood mononuclear cells of healthy humans.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

Monitoring of the conversion from triptolide to tripchlorolide in Triptergium wilfordii by micellar electrokinetic caillary chromatography.

Journal of chromatography. A 20051202

Studies on calcium dependence reveal multiple modes of action for triptolide.

Chemistry & biology 20051201

Triptolide, a diterpenoid triepoxide, induces antitumor proliferation via activation of c-Jun NH2-terminal kinase 1 by decreasing phosphatidylinositol 3-kinase activity in human tumor cells.

Biochemical and biophysical research communications 20051104

Protection effect of triptolide to liver injury in rats with severe acute pancreatitis.

Hepatobiliary & pancreatic diseases international : HBPD INT 20051101

[Inhibitory effect of triptolide on proliferation of PC12 cells].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20051101

Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking.

Blood 20051001

Inhibition of the nuclear factor-kappaB signaling pathway by leflunomide or triptolide also inhibits the anthralin-induced inflammatory response but does not affect keratinocyte growth inhibition.

Biological & pharmaceutical bulletin 20050901

Triptolide affects the differentiation, maturation and function of human dendritic cells.

International immunopharmacology 20050801

[Effects of triptolide on anti-angiogenesis by reducing expression of urokinase plasminogen activator].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20050801

Inhibitory effect of triptolide on chemokine expression induced by proinflammatory cytokines in human corneal fibroblasts.

Investigative ophthalmology & visual science 20050701

[Effect of triptolide on expression of urokinase-type plasminogen activators in vascular endothelial cells].

Ai zheng = Aizheng = Chinese journal of cancer 20050701

[Study of triptolide-induced apoptosis in MUTZ-1 cells and its allied mechanism].

Zhongguo shi yan xue ye xue za zhi 20050601

Clinical observation on effect of triptolide tablet in treating patients with psoriasis vulgaris.

Chinese journal of integrative medicine 20050601

[The effects of triptolide inhibition of mouse lymphocytes activated in vitro].

Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050601

[Effects of triptolide on migration of vascular endothelial cells].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20050501

[Effect of triptolide on urinary monocyte chemottractant protein-1 in patients with diabetic nephropathy].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050501

[Isopropyl myristate molecular gels and drug-loaded transdermal capability].

Yao xue xue bao = Acta pharmaceutica Sinica 20050501

Determination of triptolide in root extracts of Tripterygium wilfordii by solid-phase extraction and reverse-phase high-performance liquid chromatography.

Journal of chromatography. A 20050408

The research on the anti-inflammatory activity and hepatotoxicity of triptolide-loaded solid lipid nanoparticle.

Pharmacological research 20050401

Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection.

Neurobiology of disease 20050401

FK506 enhances triptolide-induced down-regulation of cyclooxygenase-2, inducible nitric oxide synthase as well as their products PGE2 and NO in TNF-alpha-stimulated synovial fibroblasts from rheumatoid arthritic patients.

European journal of medical research 20050329

Anti-inflammatory effects of triptolide loaded poly(D,L-lactic acid) nanoparticles on adjuvant-induced arthritis in rats.

Journal of ethnopharmacology 20050227

Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes.

Biochemical and biophysical research communications 20050204

Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells.

Acta pharmacologica Sinica 20050201

[Progress in research on triptolide].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

[Determination of triptolide in Tripterygium total terpenoids tablets by HPLC].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050201

Stent-based delivery of triptolide reduces neointimal formation in rabbit iliac arteries.

Chinese medical journal 20050120

Determination of triptolide and triptonide in human plasma by high-performance liquid chromatography.

Biomedical chromatography : BMC 20050101

Triptolide inhibits transcription factor NF-kappaB and induces apoptosis of multiple myeloma cells.

Leukemia research 20050101

Triptolide loaded solid lipid nanoparticle hydrogel for topical application.

Drug development and industrial pharmacy 20050101

Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines.

Immunopharmacology and immunotoxicology 20050101

Effects of triptolide on the expression and activity of NF-kappaB in synovium of collagen-induced arthritis rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.

The Journal of biological chemistry 20041224

[Influence of triptolide on neuronal apoptosis in rat with cerebral injury after focal ischemia reperfusion].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041101

Recent pharmacological studies on natural products in China.

European journal of pharmacology 20041001

[Progress in structure modification of triptolide].

Yao xue xue bao = Acta pharmaceutica Sinica 20041001

Triptolide, an active component of the Chinese herbal remedy Tripterygium wilfordii Hook F, inhibits production of nitric oxide by decreasing inducible nitric oxide synthase gene transcription.

Arthritis and rheumatism 20040901

A study of microemulsion systems for transdermal delivery of triptolide.

Journal of controlled release : official journal of the Controlled Release Society 20040827

Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation.

Biochemical and biophysical research communications 20040702

Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation.

Japanese heart journal 20040701

[Preparation and toxicity of triptolide-loaded poly (D,L-lactic acid) nanoparticles].

Yao xue xue bao = Acta pharmaceutica Sinica 20040701

Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase.

European journal of pharmacology 20040621

Biotransformation of triptolide and triptonide by cell suspension cultures of Catharanthus roseus.

Journal of Asian natural products research 20040601

New drugs to improve transplant outcomes.

Transplantation 20040515

[Regulatory function of nuclear factor kappa B on lymphocyte proliferation and apoptosis in bronchial asthmatic rats and effect of triptolide on the regulation].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20040501

Longitudinal transcriptional analysis of developing neointimal vascular occlusion and pulmonary hypertension in rats.

Physiological genomics 20040413

TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activation.

American journal of physiology. Gastrointestinal and liver physiology 20040301

Triptolide, a Chinese herbal extract, protects dopaminergic neurons from inflammation-mediated damage through inhibition of microglial activation.

Journal of neuroimmunology 20040301

[Effect of Triptolide on TNFalpha-induced activation of NF-kappaB and expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040301

[Effect of Chinese herb Tripterygium wilfordii Hook F monomer triptolide on apoptosis of PC12 cells induced by Abeta1-42].

Sheng li xue bao : [Acta physiologica Sinica] 20040225

[Progress in biotransformation of triptolides and bufadienolides].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20040201

Triptolide down-regulates bcr-abl expression and induces apoptosis in chronic myelogenous leukemia cells.

Leukemia & lymphoma 20040201

Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.

BMC pharmacology 20040101

Inhibition by triptolide of IL-1-induced collagen degradation by corneal fibroblasts.

Investigative ophthalmology & visual science 20031201

The suppressive effect of triptolide on experimental autoimmune uveoretinitis by down-regulating Th1-type response.

International immunopharmacology 20031001

Analysis of triptolide-regulated gene expression in Jurkat cells by complementary DNA microarray.

Acta pharmacologica Sinica 20030901

Solid lipid nanoparticle and microemulsion for topical delivery of triptolide.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030901

PG490-88, a derivative of triptolide, causes tumor regression and sensitizes tumors to chemotherapy.

Molecular cancer therapeutics 20030901

PG490-mediated sensitization of lung cancer cells to Apo2L/TRAIL-induced apoptosis requires activation of ERK2.

Oncogene 20030821

Immunosuppressant PG490 (triptolide) induces apoptosis through the activation of caspase-3 and down-regulation of XIAP in U937 cells.

Biochemical pharmacology 20030715

[Neuroprotective effects of Tripterygium Wilforddi Hook F monomer T10 on glutamate induced PC12 cell line damage and its mechanism].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20030618

Triptolide inhibits TNF-alpha, IL-1 beta and NO production in primary microglial cultures.

Neuroreport 20030523

[Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030301

Triptolide inhibits the growth and metastasis of solid tumors.

Molecular cancer therapeutics 20030101

Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medicinal herb Tripterygium wilfordii Hook. f.

Drugs in R&D 20030101

Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation.

Experimental & molecular medicine 20021231

Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.

Journal of immunology (Baltimore, Md. : 1950) 20021201

[Effects of chlorotriptolide and triptonide on chromosome aberration and micronuclei of bone marrow cell in male rats].

Zhonghua nan ke xue = National journal of andrology 20021201

Triptolide is a potent suppressant of C3, CD40 and B7h expression in activated human proximal tubular epithelial cells.

Kidney international 20021001

[Several monomes from Tripterygium wilfordii inhibit proliferation of glioma cells in vitro].

Ai zheng = Aizheng = Chinese journal of cancer 20021001

Triptolide inhibits proinflammatory factor-induced over-expression of class II MHC and B7 molecules in renal tubular epithelial cells.

Acta pharmacologica Sinica 20020901

Synergistic cytotoxicity and apoptosis induced in human cholangiocarcinoma cell lines by a combined treatment with tumor necrosis factor-alpha (TNF-alpha) and triptolide.

Asian Pacific journal of allergy and immunology 20020901

Liver fluke-associated cholangiocarcinoma.

The British journal of surgery 20020801

Antiproliferative and proapoptotic activities of triptolide (PG490), a natural product entering clinical trials, on primary cultures of human prostatic epithelial cells.

Clinical cancer research : an official journal of the American Association for Cancer Research 20020801

[The effect of triptolide on the proliferation of airway smooth muscle and the expression of c-fos and c-jun in asthmatic rats].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20020501

Inhibition of vascular endothelial growth factor expression and production by triptolide.

Planta medica 20020401

Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells.

Oncogene 20011129

[Triptolide inhibits vascular endothelial growth factor expression and production by endothelial cells].

Zhonghua yi xue za zhi 20010925

Triptolide, a novel diterpenoid triepoxide from Tripterygium wilfordii Hook. f., suppresses the production and gene expression of pro-matrix metalloproteinases 1 and 3 and augments those of tissue inhibitors of metalloproteinases 1 and 2 in human synovial fibroblasts.

Arthritis and rheumatism 20010901

Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F.

Leukemia & lymphoma 20010701

Triptolide inhibits vascular endothelial growth factor expression and production in endothelial cells.

Acta pharmacologica Sinica 20010701

Triptolide induced cytotoxic effects on human promyelocytic leukemia, T cell lymphoma and human hepatocellular carcinoma cell lines.

Toxicology letters 20010531

PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.

The American journal of pathology 20010301

Triptolide and chemotherapy cooperate in tumor cell apoptosis. A role for the p53 pathway.

The Journal of biological chemistry 20010119

Chiral auxiliaries for asymmetric radical cyclization reactions: application to the enantioselective synthesis of (+)-triptocallol.

Organic letters 20010111

[Determination of triptolide in human plasma by gas chromatography-electron capture detection].

Se pu = Chinese journal of chromatography 20010101

[Effect of Tripterygium wilfordii on Th1, Th2 cytokines production in asthma patients].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101

[Effect of tripterygium polyglucoside on T-lymphocyte subsets and serum interleukin-5 level in asthma patients].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010101