1,3,5-Trioxane
| Title | Journal |
|---|---|
| Malaria-infected mice live until at least day 30 after a new artemisinin-derived thioacetal thiocarbonate combined with mefloquine are administered together in a single, low, oral dose. | Journal of medicinal chemistry 20120913 |
| Transferable potentials for phase equilibria-united atom description of five- and six-membered cyclic alkanes and ethers. | The journal of physical chemistry. B 20120913 |
| Intersex effect of lamotrigine on the pharmacokinetic parameters of CDRI-97/78, a novel trioxane antimalarial compound, in rats. | Arzneimittel-Forschung 20120601 |
| 1,2-Bis[(3,6,9-trimethyl-3,12-ep-oxy-3,4,5,5a,6,7,8,8a,9,10,12,12a-dodeca-hydro-pyrano[4,3-j][1,2]benzodioxepin-4-yl)-oxy]ethane. | Acta crystallographica. Section E, Structure reports online 20120301 |
| Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. | PLoS neglected tropical diseases 20120201 |
| Formaldehyde encapsulated in lithium-decorated metal-organic frameworks: a density functional theory study. | Chemphyschem : a European journal of chemical physics and physical chemistry 20120116 |
| Anti-inflammatory and immunomodulatory mechanisms of artemisinin on contact hypersensitivity. | International immunopharmacology 20120101 |
| Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. | Journal of biomedicine & biotechnology 20120101 |
| Synthetic peroxides as potent antimalarials. News and views. | Current topics in medicinal chemistry 20120101 |
| Profiling of volatile impurities in tetramethylenedisulfotetramine (TETS) for synthetic-route determination. | Forensic science international 20110715 |
| A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice. | Bioorganic & medicinal chemistry letters 20110501 |
| Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors. | Virology journal 20110101 |
| Pharmacokinetic study of the novel, synthetic trioxane antimalarial compound 97-78 in rats using an LC-MS/MS method for quantification. | Arzneimittel-Forschung 20110101 |
| Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control. | International journal of molecular sciences 20110101 |
| Medicinal chemistry perspectives of trioxanes and tetraoxanes. | Current medicinal chemistry 20110101 |
| Liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of compound 97/78 and its in vivo metabolite 97/63, a novel trioxane antimalarial, in human plasma and its application to a protein binding study. | Arzneimittel-Forschung 20110101 |
| An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities. | PloS one 20110101 |
| Prediction of human absorption of a trioxane antimalarial drug (CDRI 99/411) using an in-house validated in situ single-pass intestinal perfusion model. | Arzneimittel-Forschung 20110101 |
| A greatly under-appreciated fundamental principle of physical organic chemistry. | International journal of molecular sciences 20110101 |
| Trioxaquines: hybrid molecules for the treatment of malaria. | Drug news & perspectives 20101201 |
| Synthesis and antimalarial assessment of a new series of orally active amino-functionalized spiro 1,2,4-trioxanes. | Journal of medicinal chemistry 20101111 |
| A suitable preparation of N-sulfonyl-1,2,3,4-tetrahydroisoquinolines and their ring homologs with a reusable Preyssler heteropolyacid as catalyst. | Molecular diversity 20101101 |
| Interspecies comparison of the pharmacokinetics and oral bioavailability of 99-357, a potent synthetic trioxane antimalarial compound. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20101009 |
| Purified E255L mutant SERCA1a and purified PfATP6 are sensitive to SERCA-type inhibitors but insensitive to artemisinins. | The Journal of biological chemistry 20100820 |
| Chain branching and termination in the low-temperature combustion of n-alkanes: 2-pentyl radical + O2, isomerization and association of the second O2. | The journal of physical chemistry. A 20100729 |
| (1R,3S,4R,4aS,7R,7aS,10R,12aR)-3-Azido-4,7,10-trimethyl-1,10-epidioxy-per-hydropyrano[4,3-j][1,2]benzodiox-epine. | Acta crystallographica. Section E, Structure reports online 20100701 |
| Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii. | Journal of medicinal chemistry 20100513 |
| Formaldehyde in the indoor environment. | Chemical reviews 20100414 |
| Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers. | PloS one 20100101 |
| The pharmaceutical death-ride of dihydroartemisinin. | Malaria journal 20100101 |
| Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose. | Journal of medicinal chemistry 20091210 |
| Different behavior of artemisinin and tetraoxane in the oxidative degradation of phospholipid. | Chemistry and physics of lipids 20090801 |
| Liquid chromatographic tandem mass spectrometric assay for quantification of 97/78 and its metabolite 97/63: a promising trioxane antimalarial in monkey plasma. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715 |
| Antimalarial peroxide dyads from natural artemisinin and hydroxyalkylated 1,2,4-trioxanes. | Journal of medicinal chemistry 20090528 |
| Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. | Journal of medicinal chemistry 20090226 |
| Diastereoselective preparation of substituted delta-valerolactones. synthesis of (3R,4S)- and (3R,4R)-simplactones. | The Journal of organic chemistry 20090206 |
| Ferrocenium salts mediate para-tert-butylcalixarene synthesis. | Chemical communications (Cambridge, England) 20081130 |
| New strategy for the construction of epoxy-bridged tetrahydropyran frameworks from trioxane precursors: application to a concise synthesis of a Riesling acetal. | The Journal of organic chemistry 20081107 |
| Piperidine dispiro-1,2,4-trioxane analogues. | Bioorganic & medicinal chemistry letters 20081101 |
| Accretion reactions of octanal catalyzed by sulfuric acid: product identification, reaction pathways, and atmospheric implications. | Environmental science & technology 20081001 |
| Elucidation of the natural artemisinin decomposition route upon iron interaction: a fine electronic redistribution promotes reactivity. | Physical chemistry chemical physics : PCCP 20080901 |
| 1,2,5,10,11,14-hexaoxadispiro[5.2.5.2]hexadecanes: novel spirofused bis-trioxane peroxides. | Molecules (Basel, Switzerland) 20080819 |
| Redetermination of 2,4,6-tricyclo-hexyl-1,3,5-trioxane. | Acta crystallographica. Section E, Structure reports online 20080701 |
| Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles. | Journal of medicinal chemistry 20080410 |
| A sensitive and selective liquid chromatographic tandem mass spectrometric assay for simultaneous quantification of novel trioxane antimalarials in different biomatrices using sample-pooling approach for high throughput pharmacokinetic studies. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315 |
| Malaria-infected mice are cured by oral administration of new artemisinin derivatives. | Journal of medicinal chemistry 20080227 |
| Hybrid molecules with a dual mode of action: dream or reality? | Accounts of chemical research 20080101 |
| Photoinduced oxygen capture on immobilized dienone systems. First solid-phase synthesis of trioxane scaffolds. | Journal of combinatorial chemistry 20080101 |
| Evaluation of some adamantane-based synthetic trioxanes against Plasmodium knowlesi in rhesus monkeys. | Life sciences 20071110 |
| Conversion of antimalarial drug artemisinin to a new series of tricyclic 1,2,4-trioxanes1. | Organic letters 20071011 |
| Malaria-infected mice are cured by a single dose of novel artemisinin derivatives. | Journal of medicinal chemistry 20070517 |
| New adamantane-based spiro 1,2,4-trioxanes orally effective against rodent and simian malaria. | Journal of medicinal chemistry 20070208 |
| Role of transferrin receptor and the ABC transporters ABCB6 and ABCB7 for resistance and differentiation of tumor cells towards artesunate. | PloS one 20070101 |
| Ensuring sustained ACT production and reliable artemisinin supply. | Malaria journal 20070101 |
| [Synthesis and antiviral activity of lupane triterpenoids with modified cycle E]. | Bioorganicheskaia khimiia 20070101 |
| Reactions of artemisinin and arteether with acid: implications for stability and mode of antimalarial action. | Journal of medicinal chemistry 20061005 |
| Quantitative NMR spectroscopy of complex technical mixtures using a virtual reference: chemical equilibria and reaction kinetics of formaldehyde-water-1,3,5-trioxane. | Analytical and bioanalytical chemistry 20060701 |
| 8-(1-Naphthalen-2-yl-vinyl)-6,7,10-trioxaspiro (4.5) decane, a new 1,2,4-trioxane effective against rodent and simian malaria. | Bioorganic & medicinal chemistry letters 20060201 |
| Enantiomeric 1,2,4-trioxanes display equivalent in vitro antimalarial activity versus Plasmodium falciparum malaria parasites: implications for the molecular mechanism of action of the artemisinins. | Chembiochem : a European journal of chemical biology 20051101 |
| New orally active spiro 1,2,4-trioxanes with high antimalarial potency. | Bioorganic & medicinal chemistry letters 20051015 |
| Conformational pathways of saturated six-membered rings. A static and dynamical density functional study. | The journal of physical chemistry. A 20050915 |
| A high throughput approach for simultaneous estimation of multiple synthetic trioxane derivatives using sample pooling for pharmacokinetic studies. | Journal of pharmaceutical and biomedical analysis 20050207 |
| Novel spiroanellated 1,2,4-trioxanes with high in vitro antimalarial activities. | Bioorganic & medicinal chemistry letters 20050201 |
| Synthesis and antimalarial activity of 6-cycloalkylvinyl substituted 1,2,4-trioxanes. | Bioorganic & medicinal chemistry 20041115 |
| HPLC-UV method for assaying 99/357, a synthetic trioxane antimalarial derivative in rat and rabbit serum. | Journal of pharmaceutical and biomedical analysis 20041029 |
| Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore. | Organic letters 20040902 |
| Synthesis and antimalarial activity of trioxaquine derivatives. | Chemistry (Weinheim an der Bergstrasse, Germany) 20040402 |
| Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo. | British journal of clinical pharmacology 20040401 |
| Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin. | Journal of medicinal chemistry 20040226 |
| Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. | Journal of medicinal chemistry 20040226 |
| Development of artemisinin and its structurally simplified trioxane derivatives as antimalarial drugs. | Acta tropica 20040201 |
| Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane. | Organic & biomolecular chemistry 20030821 |
| Chloroquine and artemisinin: six decades of research--what next? | IDrugs : the investigational drugs journal 20030701 |
| Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds. | International journal for parasitology 20021204 |
| Malaria: new chemotherapeutic peroxide drugs. | Mini reviews in medicinal chemistry 20021201 |
| Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents. | Journal of medicinal chemistry 20020829 |
| From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs. | Accounts of chemical research 20020301 |
| Biodegradation of formaldehyde and its derivatives in industrial wastewater with methylotrophic yeast Hansenula polymorpha and with the yeast-bioaugmented activated sludge. | Biodegradation 20020101 |
| Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents. | Journal of medicinal chemistry 20010913 |
| Quantitative (13)C NMR analysis of lignins with internal standards. | Journal of agricultural and food chemistry 20010801 |