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S-Adenosyl-l-methionine

CAS No.:
29908-03-0
Catalog Number:
AG0035KP
Molecular Formula:
C15H22N6O5S
Molecular Weight:
398.4374
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Purity
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Product Description
Catalog Number:
AG0035KP
Chemical Name:
S-Adenosyl-l-methionine
CAS Number:
29908-03-0
Molecular Formula:
C15H22N6O5S
Molecular Weight:
398.4374
MDL Number:
MFCD00871208
IUPAC Name:
(2S)-2-amino-4-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl-methylsulfonio]butanoate
InChI:
InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27?/m0/s1
InChI Key:
MEFKEPWMEQBLKI-AIRLBKTGSA-N
SMILES:
C[S+](C[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)CC[C@@H](C(=O)[O-])N
EC Number:
249-946-8
Properties
Complexity:
527  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
0
Exact Mass:
398.137g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
398.438g/mol
Monoisotopic Mass:
398.137g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
187A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-2.8  
Literature
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Genetic modification and bioprocess optimization for S-Adenosyl-L-methionine biosynthesis. Sub-cellular biochemistry 20120101
CYP2E1 potentiates toxicity in obesity and after chronic ethanol treatment. Drug metabolism and drug interactions 20120101
Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT. Molecular cell 20111223
Synthesis of an azide-bearing N-mustard analogue of S-adenosyl-L-methionine. The Journal of organic chemistry 20111216
Arabidopsis calcium-binding mitochondrial carrier proteins as potential facilitators of mitochondrial ATP-import and plastid SAM-import. FEBS letters 20111215
Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. Journal of the American Chemical Society 20111214
Pneumocystis S-adenosylmethionine transport: a potential drug target. American journal of respiratory cell and molecular biology 20111201
Homocysteine-induced cardiomyocyte apoptosis and plasma membrane flip-flop are independent of S-adenosylhomocysteine: a crucial role for nuclear p47(phox). Molecular and cellular biochemistry 20111201
S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used? Bioorganic chemistry 20111201
Biochemical disorders associated with antiproliferative effect of dehydroepiandrosterone in hepatoma cells as revealed by LC-based metabolomics. Biochemical pharmacology 20111201
Structural characterization of BVU_3255, a methyltransferase from human intestine antibiotic resistant pathogen Bacteroides vulgatus. Journal of structural biology 20111201
Proteomic analysis of a sea-ice diatom: salinity acclimation provides new insight into the dimethylsulfoniopropionate production pathway. Plant physiology 20111201
The PRPP synthetase spectrum: what does it demonstrate about nucleotide syndromes? Nucleosides, nucleotides & nucleic acids 20111201
S K-edge XAS and DFT calculations on SAM dependent pyruvate formate-lyase activating enzyme: nature of interaction between the Fe4S4 cluster and SAM and its role in reactivity. Journal of the American Chemical Society 20111123
RAM/Fam103a1 is required for mRNA cap methylation. Molecular cell 20111118
Elucidation of the methyl transfer mechanism catalyzed by chalcone O-methyltransferase: a density functional study. Journal of computational chemistry 20111115
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 20111111
Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors. Journal of medicinal chemistry 20111110
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Computational investigation of the substrate recognition mechanism of protein D-aspartyl (L-isoaspartyl) O-methyltransferase by docking and molecular dynamics simulation studies and application to interpret size exclusion chromatography data. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111101
Formulating a fluorogenic assay to evaluate S-adenosyl-L-methionine analogues as protein methyltransferase cofactors. Molecular bioSystems 20111101
S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcoholism, clinical and experimental research 20111101
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In vitro phosphinate methylation by PhpK from Kitasatospora phosalacinea. Biochemistry 20111025
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. The Journal of biological chemistry 20111021
The structure of a tetrahydrofolate-sensing riboswitch reveals two ligand binding sites in a single aptamer. Structure (London, England : 1993) 20111012
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. American journal of human genetics 20111007
Copper deficiency exacerbates bile duct ligation-induced liver injury and fibrosis in rats. The Journal of pharmacology and experimental therapeutics 20111001
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Structural basis of substrate methylation and inhibition of SMYD2. Structure (London, England : 1993) 20110907
Complex biotransformations catalyzed by radical S-adenosylmethionine enzymes. The Journal of biological chemistry 20110902
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Sulfatases and a radical S-adenosyl-L-methionine (AdoMet) enzyme are key for mucosal foraging and fitness of the prominent human gut symbiont, Bacteroides thetaiotaomicron. The Journal of biological chemistry 20110722
Expanding cofactor repertoire of protein lysine methyltransferase for substrate labeling. ACS chemical biology 20110715
Probing the reaction mechanism of spore photoproduct lyase (SPL) via diastereoselectively labeled dinucleotide SP TpT substrates. Journal of the American Chemical Society 20110713
Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. RNA (New York, N.Y.) 20110701
Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity. Nutrition research (New York, N.Y.) 20110701
Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: a [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme. The Journal of biological chemistry 20110617
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay. Analytical chemistry 20110615
Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner. Archives of toxicology 20110601
S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats. Experimental and molecular pathology 20110601
A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase. Journal of biomolecular screening 20110601
Hypoxia induces genomic DNA demethylation through the activation of HIF-1α and transcriptional upregulation of MAT2A in hepatoma cells. Molecular cancer therapeutics 20110601
Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue. The FEBS journal 20110601
Generation of adenosyl radical from S-adenosylmethionine (SAM) in biotin synthase. Journal of inorganic biochemistry 20110601
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. RNA (New York, N.Y.) 20110601
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. RNA (New York, N.Y.) 20110601
HIV-associated Pneumocystis pneumonia. Proceedings of the American Thoracic Society 20110601
Complementary and alternative medicine for the treatment of major depressive disorder. Canadian family physician Medecin de famille canadien 20110601
Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9. The Journal of biological chemistry 20110527
Structural basis for methyl transfer by a radical SAM enzyme. Science (New York, N.Y.) 20110527
Labeling substrates of protein arginine methyltransferase with engineered enzymes and matched S-adenosyl-L-methionine analogues. Journal of the American Chemical Society 20110525
Crystal structures and enzymatic properties of a triamine/agmatine aminopropyltransferase from Thermus thermophilus. Journal of molecular biology 20110520
The effects of dietary supplementation of methionine on genomic stability and p53 gene promoter methylation in rats. Mutation research 20110518
Mechanistic studies of the radical S-adenosyl-L-methionine enzyme DesII: EPR characterization of a radical intermediate generated during its catalyzed dehydrogenation of TDP-D-quinovose. Journal of the American Chemical Society 20110518
Concentrations of unmetabolized folic acid and primary folate forms in plasma after folic acid treatment in older adults. Metabolism: clinical and experimental 20110501
Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review. Rheumatology (Oxford, England) 20110501
Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats. Cardiovascular research 20110501
S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase A pathway. The Journal of pharmacology and experimental therapeutics 20110501
Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system. Biochimica et biophysica acta 20110501
The mPlrp2 and mClps genes are involved in the hydrolysis of retinyl esters in the mouse liver. Journal of lipid research 20110501
The role of S-adenosyl methionine in preventing FOLFOX-induced liver toxicity: a retrospective analysis in patients affected by resected colorectal cancer treated with adjuvant FOLFOX regimen. Expert opinion on drug safety 20110501
Phloem-specific expression of Yang cycle genes and identification of novel Yang cycle enzymes in Plantago and Arabidopsis. The Plant cell 20110501
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. PLoS pathogens 20110501
[Pay more attention to standardizing the diagnosis and treatment of intrahepatic cholestasis of pregnancy]. Zhonghua fu chan ke za zhi 20110501
S-adenosyl-L-methionine induces compaction of nascent peptide chain inside the ribosomal exit tunnel upon translation arrest in the Arabidopsis CGS1 gene. The Journal of biological chemistry 20110429
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Science (New York, N.Y.) 20110429
Biochemistry. The two faces of SAM. Science (New York, N.Y.) 20110429
Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. Biochemistry 20110426
Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase. Chemistry & biology 20110422
Mechanism of Vibrio cholerae autoinducer-1 biosynthesis. ACS chemical biology 20110415
S-Adenosylmethionine regulates connexins sub-types expressed by hepatocytes. European journal of cell biology 20110401
Radicals from S-adenosylmethionine and their application to biosynthesis. Current opinion in chemical biology 20110401
Thymidylate synthase gene polymorphisms and markers of DNA methylation capacity. Molecular genetics and metabolism 20110401
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The C. elegans PRMT-3 possesses a type III protein arginine methyltransferase activity. Journal of receptor and signal transduction research 20110401
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[FeFe]-hydrogenase maturation: HydG-catalyzed synthesis of carbon monoxide. Journal of the American Chemical Society 20100714
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High affinity S-Adenosylmethionine plasma membrane transporter of Leishmania is a member of the folate biopterin transporter (FBT) family. The Journal of biological chemistry 20100625
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In vivo proton MR spectroscopy findings specific for adenylosuccinate lyase deficiency. NMR in biomedicine 20100601
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SAMe prevents the up regulation of toll-like receptor signaling in Mallory-Denk body forming hepatocytes. Experimental and molecular pathology 20100601
SAMe prevents the induction of the immunoproteasome and preserves the 26S proteasome in the DDC-induced MDB mouse model. Experimental and molecular pathology 20100601
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The major product ion of S-adenosyl-L-methionine arises from a neighbouring group reaction. Rapid communications in mass spectrometry : RCM 20100530
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Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicological sciences : an official journal of the Society of Toxicology 20100501
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Formation of spray-dried powder of S-adenosyl-L-methionine. Biotechnology journal 20100501
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Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation. Journal of proteome research 20100405
Evaluation of phospholipid and liposomal S-adenosyl methionine for the treatment of liver injury in a murine model. Journal of pharmaceutical sciences 20100401
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Automatic policing of biochemical annotations using genomic correlations. Nature chemical biology 20100101
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An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations. Archives of biochemistry and biophysics 20091201
Update and critique of natural remedies as antidepressant treatments. Obstetrics and gynecology clinics of North America 20091201
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An enzyme-coupled continuous spectrophotometric assay for magnesium protoporphyrin IX methyltransferases. Analytical biochemistry 20091115
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Characterization of RimO, a new member of the methylthiotransferase subclass of the radical SAM superfamily. Biochemistry 20091027
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Complete reconstitution of a highly reducing iterative polyketide synthase. Science (New York, N.Y.) 20091023
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Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening. Journal of medicinal chemistry 20091008
Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. Journal of the American Chemical Society 20091007
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The Pseudomonas aeruginosa nirE gene encodes the S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase required for heme d(1) biosynthesis. The FEBS journal 20091001
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Oxidative stress-induced regulation of the methionine metabolic pathway in human lung epithelial-like (A549) cells. Mutation research 20090331
Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase. Biochemistry 20090324
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: studies of adenine C8 substitution in structural analogues of S-adenosylmethionine. Journal of medicinal chemistry 20090312
Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells. Cell research 20090301
Hyperhomocysteinemia induces a tissue specific accumulation of homocysteine in bone by collagen binding and adversely affects bone. Bone 20090301
Effects of insulin and glucose on cellular metabolic fluxes in homocysteine transsulfuration, remethylation, S-adenosylmethionine synthesis, and global deoxyribonucleic acid methylation. The Journal of clinical endocrinology and metabolism 20090301
Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments. Nutrition reviews 20090301
Identification of stable S-adenosylmethionine (SAM) analogues derivatised with bioorthogonal tags: effect of ligands on the affinity of the E. coli methionine repressor, MetJ, for its operator DNA. Organic & biomolecular chemistry 20090221
An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene. Proteins 20090215
Evaluations of the trans-sulfuration pathway in multiple liver toxicity studies. Toxicology and applied pharmacology 20090215
Taurine supplementation improves the utilization of sulfur-containing amino acids in rats continually administrated alcohol. The Journal of nutritional biochemistry 20090201
Liposome dependent delivery of S-adenosyl methionine to cells by liposomes: a potential treatment for liver disease. Journal of pharmaceutical sciences 20090201
Structure-function relationships in methionine adenosyltransferases. Cellular and molecular life sciences : CMLS 20090201
In utero ethanol exposure impairs defenses against experimental group B streptococcus in the term Guinea pig lung. Alcoholism, clinical and experimental research 20090201
Anaerobic functionalization of unactivated C-H bonds. Current opinion in chemical biology 20090201
Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers. Clinical therapeutics 20090201
Reaction of AdoMet with ThiC generates a backbone free radical. Biochemistry 20090120
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. The Journal of biological chemistry 20090116
Recognition of RNA cap in the Wesselsbron virus NS5 methyltransferase domain: implications for RNA-capping mechanisms in Flavivirus. Journal of molecular biology 20090109
Complementary and alternative medicine for perinatal depression. Journal of affective disorders 20090101
Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090101
S-adenosyl-L-methionine co-administration prevents the ethanol-elicited dissociation of hepatic mitochondrial ribosomes in male rats. Alcoholism, clinical and experimental research 20090101
Resveratrol supplementation worsen the dysregulation of genes involved in hepatic lipid homeostasis observed in hyperhomocysteinemic mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090101
Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. The American journal of clinical nutrition 20090101
The polyamine and histamine metabolic interplay in cancer and chronic inflammation. Current opinion in clinical nutrition and metabolic care 20090101
S-Adenosyl-L-methionine increases serum BUN and creatinine in cisplatin-treated mice. Archives of medical research 20090101
Dietary selenium (Se) and copper (Cu) interact to affect homocysteine metabolism in rats. Biological trace element research 20090101
Possible role of S-adenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease. Journal of Alzheimer's disease : JAD 20090101
Application of fluorescent measurements for characterization of riboswitch-ligand interactions. Methods in molecular biology (Clifton, N.J.) 20090101
Dietary deficiency in folate and vitamin E under conditions of oxidative stress increases phospho-tau levels: potentiation by ApoE4 and alleviation by S-adenosylmethionine. Journal of Alzheimer's disease : JAD 20090101
Polyunsaturated fatty acid and S-adenosylmethionine supplementation in predementia syndromes and Alzheimer's disease: a review. TheScientificWorldJournal 20090101
Boron deprivation decreases liver S-adenosylmethionine and spermidine and increases plasma homocysteine and cysteine in rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20090101
Homocysteine metabolism and cerebrospinal fluid markers for Alzheimer's disease. Journal of Alzheimer's disease : JAD 20090101
Tyrosine, cysteine, and S-adenosyl methionine stimulate in vitro [FeFe] hydrogenase activation. PloS one 20090101
Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PloS one 20090101
[Lipid peroxidation and antioxidant system status in patients with acute myeloblast leukemia and toxic damage of the liver]. Likars'ka sprava 20090101
A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT). Journal of the American Chemical Society 20081231
Excessive S-adenosyl-L-methionine-dependent methylation increases levels of methanol, formaldehyde and formic acid in rat brain striatal homogenates: possible role in S-adenosyl-L-methionine-induced Parkinson's disease-like disorders. Life sciences 20081219
Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice. Physical biology 20081219
Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone. The Journal of biological chemistry 20081212
Spectroscopic study of the cobalamin-dependent methionine synthase in the activation conformation: effects of the Y1139 residue and S-adenosylmethionine on the B12 cofactor. Journal of the American Chemical Society 20081203
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates. Clinica chimica acta; international journal of clinical chemistry 20081201
Lack of effect of diet-induced hypomethylation on endothelium-dependent relaxation in rats. Clinical nutrition (Edinburgh, Scotland) 20081201
Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii. Journal of molecular biology 20081121
Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis. The Journal of biological chemistry 20081107
Antifungal activity of 25-azalanosterol against Candida species. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20081101
Assays for S-adenosylmethionine (AdoMet/SAM)-dependent methyltransferases. Current protocols in toxicology 20081101
Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain research 20081027
Effects of different glycerol feeding strategies on S-adenosyl-l-methionine biosynthesis by P(GAP)-driven Pichia pastoris overexpressing methionine adenosyltransferase. Journal of biotechnology 20081010
Ergot alkaloid biosynthesis in Aspergillus fumigatus. Overproduction and biochemical characterization of a 4-dimethylallyltryptophan N-methyltransferase. The Journal of biological chemistry 20081003
The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. Digestive diseases and sciences 20081001
A hydrophilic-interaction chromatography tandem mass spectrometry method for quantitation of serum s-adenosylmethionine in patients infected with human immunodeficiency virus. Clinica chimica acta; international journal of clinical chemistry 20081001
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Laboratory investigation; a journal of technical methods and pathology 20081001
S-adenosylmethionine and proliferation: new pathways, new targets. Biochemical Society transactions 20081001
Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism. Nature structural & molecular biology 20081001
Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates. Acta pharmacologica Sinica 20081001
[Pre-L-methionine feeding strategy for S-adenosyl-L-methionine fermentative production]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20081001
Crystal structure of the Thermus thermophilus 16 S rRNA methyltransferase RsmC in complex with cofactor and substrate guanosine. The Journal of biological chemistry 20080926
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem : a European journal of chemical biology 20080922
ThiC is an [Fe-S] cluster protein that requires AdoMet to generate the 4-amino-5-hydroxymethyl-2-methylpyrimidine moiety in thiamin synthesis. Biochemistry 20080902
Complementary and alternative medicine in the treatment of bipolar disorder--a review of the evidence. Journal of affective disorders 20080901
S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Archives of biochemistry and biophysics 20080901
Elevated serum levels of S-adenosylhomocysteine, but not homocysteine, are associated with cardiovascular disease in stage 5 chronic kidney disease patients. Clinica chimica acta; international journal of clinical chemistry 20080901
Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. Journal of clinical immunology 20080901
The methylation, neurotransmitter, and antioxidant connections between folate and depression. Alternative medicine review : a journal of clinical therapeutic 20080901
Wheat coleoptile endonuclease Wen2 is dependent on S-adenosyl-L-methionine and sensitive to DNA methylation status. Biochemistry. Biokhimiia 20080901
Are nutritional supplements ready for prime time? The Journal of clinical psychiatry 20080901
Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy. Biochemistry 20080826
3-Methylarginine from Pseudomonas syringae pv. syringae 22d/93 suppresses the bacterial blight caused by its close relative Pseudomonas syringae pv. glycinea. Chembiochem : a European journal of chemical biology 20080811
Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma. World journal of gastroenterology 20080807
Association between decreased vitamin levels and MTHFR, MTR and MTRR gene polymorphisms as determinants for elevated total homocysteine concentrations in pregnant women. European journal of clinical nutrition 20080801
S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Shock (Augusta, Ga.) 20080801
Deficiency in l-serine deaminase results in abnormal growth and cell division of Escherichia coli K-12. Molecular microbiology 20080801
Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site. Lipids 20080801
Maternal global methylation status and risk of congenital heart diseases. Obstetrics and gynecology 20080801
Analysis of AI-2/LuxS-dependent transcription in Campylobacter jejuni strain 81-176. Foodborne pathogens and disease 20080801
Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats. Chemico-biological interactions 20080730
S-Adenosyl-l-methionine activates the cardiac ryanodine receptor. Biochemical and biophysical research communications 20080711
Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. The Journal of biological chemistry 20080711
Structural, functional and calorimetric investigation of MosA, a dihydrodipicolinate synthase from Sinorhizobium meliloti l5-30, does not support involvement in rhizopine biosynthesis. Chembiochem : a European journal of chemical biology 20080702
Random mutagenesis and recombination of sam1 gene by integrating error-prone PCR with staggered extension process. Biotechnology letters 20080701
A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1. Molecular and cellular biochemistry 20080701
Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20080701
Juvenile hormone acid O-methyltransferase in Drosophila melanogaster. Insect biochemistry and molecular biology 20080701
Reduced brain choline in homocystinuria due to remethylation defects. Neurology 20080701
S-adenosylmethionine mediates glutathione efficacy by increasing glutathione S-transferase activity: implications for S-adenosyl methionine as a neuroprotective dietary supplement. Journal of Alzheimer's disease : JAD 20080701
Anaerobic sulfatase-maturating enzymes, first dual substrate radical S-adenosylmethionine enzymes. The Journal of biological chemistry 20080627
Crystal structures of human 108V and 108M catechol O-methyltransferase. Journal of molecular biology 20080627
Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8. Biochemistry 20080624
Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression. The Journal of nutritional biochemistry 20080601
Riboswitch effectors as protein enzyme cofactors. RNA (New York, N.Y.) 20080601
The biochemical structure and function of methylenetetrahydrofolate reductase provide the rationale to interpret the epidemiological results on the risk for infants with Down syndrome. American journal of medical genetics. Part A 20080601
Nonsurgical resolution of gallbladder mucocele in two dogs. Journal of the American Veterinary Medical Association 20080601
S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology (Baltimore, Md.) 20080501
An allosteric mechanism for switching between parallel tracks in mammalian sulfur metabolism. PLoS computational biology 20080501
Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis. Critical reviews in food science and nutrition 20080501
Comparison of the effects of buthioninesulfoximine and phorone on the metabolism of sulfur-containing amino acids in rat liver. Biochemical and biophysical research communications 20080418
A kinetic study of human protein arginine N-methyltransferase 6 reveals a distributive mechanism. The Journal of biological chemistry 20080411
Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. The Journal of biological chemistry 20080404
Homocysteine, S-adenosylmethionine and S-adenosylhomocysteine are associated with retinal microvascular abnormalities: the Hoorn Study. Clinical science (London, England : 1979) 20080401
S-Adenosylmethionine induces BldH and activates secondary metabolism by involving the TTA-codon control of bldH expression in Streptomyces lividans. Archives of microbiology 20080401
B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Molecular and cellular neurosciences 20080401
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology (Baltimore, Md.) 20080401
Overexpression of yeast S-adenosylmethionine synthetase metK in Streptomyces actuosus leads to increased production of nosiheptide. Applied microbiology and biotechnology 20080401
Dietary and genetic compromise in folate availability reduces acetylcholine, cognitive performance and increases aggression: critical role of S-adenosyl methionine. The journal of nutrition, health & aging 20080401
The differential NF-kB modulation by S-adenosyl-L-methionine, N-acetylcysteine and quercetin on the promotion stage of chemical hepatocarcinogenesis. Free radical research 20080401
Riboswitches that sense S-adenosylmethionine and S-adenosylhomocysteine. Biochemistry and cell biology = Biochimie et biologie cellulaire 20080401
Oxygen vectors used for S-adenosylmethionine production in recombinant Pichia pastoris with sorbitol as supplemental carbon source. Journal of bioscience and bioengineering 20080401
Riboswitches that sense S-adenosylhomocysteine and activate genes involved in coenzyme recycling. Molecular cell 20080328
Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum. The Journal of biological chemistry 20080321
Mechanism and tissue specificity of nicotine-mediated lung S-adenosylmethionine reduction. The Journal of biological chemistry 20080321
Folate deprivation increases tau phosphorylation by homocysteine-induced calcium influx and by inhibition of phosphatase activity: Alleviation by S-adenosyl methionine. Brain research 20080314
Reactivity and reaction order in acylhomoserine lactone formation by Pseudomonas aeruginosa RhlI. Biochemistry 20080304
Beneficial drugs for liver diseases. Journal of applied toxicology : JAT 20080301
Homocysteine-mediated PPARalpha,gamma DNA methylation and its potential pathogenic mechanism in monocytes. DNA and cell biology 20080301
Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes. Molecular and cellular biology 20080301
Ribosome stacking defines CGS1 mRNA degradation sites during nascent peptide-mediated translation arrest. Plant & cell physiology 20080301
S-Adenosylmethionine in cell growth, apoptosis and liver cancer. Journal of gastroenterology and hepatology 20080301
[Protection effects of S-adenosyl-L-methionine on lead-exposed rats during development and its mechanism of long-term potentiation]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20080301
A universal competitive fluorescence polarization activity assay for S-adenosylmethionine utilizing methyltransferases. Analytical biochemistry 20080215
Alpha anomer of 5-aza-2'-deoxycytidine down-regulates hTERT mRNA expression in human leukemia HL-60 cells. Biochemical pharmacology 20080215
Folding of the SAM aptamer is determined by the formation of a K-turn-dependent pseudoknot. Biochemistry 20080212
Comparison of S-adenosyl-L-methionine (SAMe) and N-acetylcysteine (NAC) protective effects on hepatic damage when administered after acetaminophen overdose. Toxicology 20080203
S-adenosylmethionine and its products. Amino acids 20080201
Folate status and S-adenosylmethionine/S-adenosylhomocysteine ratio in colorectal adenocarcinoma in humans. European journal of clinical nutrition 20080201
Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women. Clinica chimica acta; international journal of clinical chemistry 20080201
S-adenosylmethionine prevents Mallory Denk body formation in drug-primed mice by inhibiting the epigenetic memory. Hepatology (Baltimore, Md.) 20080201
Complementary medicines in pediatric bipolar disorder. Minerva pediatrica 20080201
Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA. Journal of molecular biology 20080125
The histamine N-methyltransferase T105I polymorphism affects active site structure and dynamics. Biochemistry 20080122
Dietary supplements for osteoarthritis. American family physician 20080115
S-adenosyl L-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture. International journal of cancer 20080101
Ethanol-induced increased endogenous homocysteine levels and decreased ratios of SAM/SAH are only partially attenuated by exogenous glycine in developing chick brains. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080101
Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nature chemical biology 20080101
Expression of secreted His-tagged S-adenosylmethionine synthetase in the methylotrophic yeast Pichia pastoris and its characterization, one-step purification, and immobilization. Biotechnology progress 20080101
Mammalian cytosine DNA methyltransferase Dnmt1: enzymatic mechanism, novel mechanism-based inhibitors, and RNA-directed DNA methylation. Current medicinal chemistry 20080101
Detection and quantitation of the activity of DNA methyltransferases using a biotin/avidin microplate assay. Methods in molecular biology (Clifton, N.J.) 20080101
The Radical SAM Superfamily. Critical reviews in biochemistry and molecular biology 20080101
[Pathogenesis and progress in treatment of neonatal total parenteral nutrition-associated cholestasis]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20080101
Antiapoptotic role of S-adenosyl-l-methionine against hydrochloric acid induced cell death in Saccharomyces cerevisiae. Biochimica et biophysica acta 20080101
Effect of S-adenosylmethionine tablets on the reduction of age-related mental decline in dogs: a double-blinded, placebo-controlled trial. Veterinary therapeutics : research in applied veterinary medicine 20080101
Methylation status in healthy subjects with normal and high serum folate concentration. Nutrition (Burbank, Los Angeles County, Calif.) 20080101
S-Adenosylhomocysteine hydrolase overexpression in HEK-293 cells: effect on intracellular adenosine levels, cell viability, and DNA methylation. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101
Transition state analogues in quorum sensing and SAM recycling. Nucleic acids symposium series (2004) 20080101
Methionine metabolism in an animal model of sepsis. Clinical chemistry and laboratory medicine 20080101
Requirement of RIZ1 for cancer prevention by methyl-balanced diet. PloS one 20080101
Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. PloS one 20080101
Hypermethylation of Fads2 and altered hepatic fatty acid and phospholipid metabolism in mice with hyperhomocysteinemia. The Journal of biological chemistry 20071221
Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin. Journal of the American Chemical Society 20071212
Cadmium induced oxidative stress in soybean plants also by the accumulation of delta-aminolevulinic acid. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20071201
Influence of preconditioning-like hypoxia on the liver of developing methyl-deficient rats. American journal of physiology. Endocrinology and metabolism 20071201
Stability of plasma homocysteine, S-adenosylmethionine, and S-adenosylhomocysteine in EDTA, acidic citrate, and Primavette collection tubes. Clinical chemistry 20071201
Mechanism of enzymatic fluorination in Streptomyces cattleya. Journal of the American Chemical Society 20071128
Binding energy in the one-electron reductive cleavage of S-adenosylmethionine in lysine 2,3-aminomutase, a radical SAM enzyme. Biochemistry 20071113
AdoMet-dependent methyl-transfer: Glu119 is essential for DNA C5-cytosine methyltransferase M.HhaI. Journal of molecular biology 20071109
The many flavors of hyperhomocyst(e)inemia: insights from transgenic and inhibitor-based mouse models of disrupted one-carbon metabolism. Antioxidants & redox signaling 20071101
Mechanisms of protection by the betaine-homocysteine methyltransferase/betaine system in HepG2 cells and primary mouse hepatocytes. Hepatology (Baltimore, Md.) 20071101
S-adenosylmethionine attenuates oxidative liver injury in micropigs fed ethanol with a folate-deficient diet. Alcoholism, clinical and experimental research 20071101
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver. Hepatology (Baltimore, Md.) 20071101
[Cholestasis of pregnancy]. Gastroenterologia y hepatologia 20071101
Continuous enzymatic assay for histone lysine methyltransferases. BioTechniques 20071101
Genetic characterization of two S-adenosylmethionine-induced ABC transporters reveals their roles in modulations of secondary metabolism and sporulation in Streptomyces coelicolor M145. Journal of microbiology and biotechnology 20071101
S-adenosylmethionine-dependent protein methylation in mammalian cytosol via tyrphostin modification by catechol-O-methyltransferase. The Journal of biological chemistry 20071019
Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. Archives of biochemistry and biophysics 20071015
Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO. Journal of molecular biology 20071012
Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. Journal of molecular biology 20071005
The import of S-adenosylmethionine into the Golgi apparatus is required for the methylation of homogalacturonan. Plant physiology 20071001
S-adenosylmethionine as a biomarker for the early detection of lung cancer. Chest 20071001
Self-sacrifice in radical S-adenosylmethionine proteins. Current opinion in chemical biology 20071001
S-adenosyl-L-methionine:magnesium-protoporphyrin IX O-methyltransferase from Rhodobacter capsulatus: mechanistic insights and stimulation with phospholipids. The Biochemical journal 20070915
Study of bacteriophage T4-encoded Dam DNA (adenine-N6)-methyltransferase binding with substrates by rapid laser UV cross-linking. The Journal of biological chemistry 20070907
Supranormal dietary folic acid supplementation: effects on methionine metabolism in weanling rats. The British journal of nutrition 20070901
Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans. Journal of structural biology 20070901
Marked elevation in homocysteine and homocysteine sulfinic acid in the cerebrospinal fluid of lymphoma patients receiving intensive treatment with methotrexate. International journal of clinical pharmacology and therapeutics 20070901
[Efficacy and safety of heptral, vitamin B6 and folic acid during toxic hepatitis induced by CCL4]. Georgian medical news 20070901
Two threonine residues required for role of AfsKav in controlling morphogenesis and avermectin production in Streptomyces avermitilis. Journal of microbiology and biotechnology 20070901
Structure-based activity prediction for an enzyme of unknown function. Nature 20070816
The carboxyl-terminal extension of yeast tRNA m5C methyltransferase enhances the catalytic efficiency of the amino-terminal domain. The Journal of biological chemistry 20070810
Homocysteine affects cardiomyocyte viability: concentration-dependent effects on reversible flip-flop, apoptosis and necrosis. Apoptosis : an international journal on programmed cell death 20070801
Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis 20070801
Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine. Journal of neurochemistry 20070801
Testosterone regulation of renal cystathionine beta-synthase: implications for sex-dependent differences in plasma homocysteine levels. American journal of physiology. Renal physiology 20070801
Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269. Protein science : a publication of the Protein Society 20070801
Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs. DNA and cell biology 20070801
Nutraceuticals in the management of osteoarthritis. Orthopedics 20070801
S-adenosyl-L-methionine-dependent methyl transfer: observable precatalytic intermediates during DNA cytosine methylation. Biochemistry 20070731
S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury. American journal of physiology. Gastrointestinal and liver physiology 20070701
S-adenosylmethionine attenuates hepatic lipid synthesis in micropigs fed ethanol with a folate-deficient diet. Alcoholism, clinical and experimental research 20070701
Identification of a ubiG-like gene involved in ubiquinone biosynthesis from Chlamydophila pneumoniae AR39. Letters in applied microbiology 20070701
Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology 20070701
Functional characterization of the recombinant N-methyltransferase domain from the multienzyme enniatin synthetase. Chembiochem : a European journal of chemical biology 20070618
Protein interactions in the human methionine synthase-methionine synthase reductase complex and implications for the mechanism of enzyme reactivation. Biochemistry 20070612
Accumulation of proteins bearing atypical isoaspartyl residues in livers of alcohol-fed rats is prevented by betaine administration: effects on protein-L-isoaspartyl methyltransferase activity. Journal of hepatology 20070601
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency. Molecular genetics and metabolism 20070601
Structural bases for substrate recognition and activity in Meaban virus nucleoside-2'-O-methyltransferase. Protein science : a publication of the Protein Society 20070601
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells. Archives of biochemistry and biophysics 20070601
S-adenosylmethionine exerts a protective effect against thioacetamide-induced injury in primary cultures of rat hepatocytes. Alternatives to laboratory animals : ATLA 20070601
gamma-Secretase is differentially modulated by alterations of homocysteine cycle in neuroblastoma and glioblastoma cells. Journal of Alzheimer's disease : JAD 20070601
Making the connections--the crucial role of metabolite transporters at the interface between chloroplast and cytosol. FEBS letters 20070525
The diverse members of the mitochondrial carrier family in plants. FEBS letters 20070525
DNA methylation status is not impaired in treated cystathionine beta-synthase (CBS) deficient patients. Molecular genetics and metabolism 20070501
Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Molecular genetics and metabolism 20070501
Role of S-adenosyl-L-methionine in liver health and injury. Hepatology (Baltimore, Md.) 20070501
Vitamins and entacapone in levodopa-induced hyperhomocysteinemia: a randomized controlled study. Neurology 20070424
A pathogenic linked mutation in the catalytic core of human cystathionine beta-synthase disrupts allosteric regulation and allows kinetic characterization of a full-length dimer. Biochemistry 20070403
Repair of alkylated DNA: recent advances. DNA repair 20070401
Folate restriction and methylenetetrahydrofolate reductase 677T polymorphism decreases adoMet synthesis via folate-dependent remethylation in human-transformed lymphoblasts. Leukemia 20070401
Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects. The American journal of clinical nutrition 20070401
Abnormal folate metabolism in foetuses affected by neural tube defects. Brain : a journal of neurology 20070401
Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. The Journal of biological chemistry 20070323
S-Adenosylmethionine in protozoan parasites: functions, synthesis and regulation. Molecular and biochemical parasitology 20070301
S-adenosylmethionine as an oxidant: the radical SAM superfamily. Trends in biochemical sciences 20070301
Nonalcoholic fatty liver disease: predisposing factors and the role of nutrition. The Journal of nutritional biochemistry 20070301
S-adenosylmethionine and radical-based catalysis. Amino acids 20070201
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. Journal of hepatology 20070201
Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. Biochimica et biophysica acta 20070201
Crystal structure and solution characterization of the activation domain of human methionine synthase. The FEBS journal 20070201
Adenosine metabolism and its effect on methylation potential in cultured cells: methodological considerations. Cellular and molecular biology (Noisy-le-Grand, France) 20070121
Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells. Experimental cell research 20070115
S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis. Neuroreport 20070108
Long term low-dose arsenic exposure induces loss of DNA methylation. Biochemical and biophysical research communications 20070105
Modulation of DNA methyltransferase profile by methyl donor starvation followed by gamma irradiation. Molecular and cellular biochemistry 20070101
Inhibition of human betaine-homocysteine methyltransferase expression by S-adenosylmethionine and methylthioadenosine. The Biochemical journal 20070101
Global metabolic changes following loss of a feedback loop reveal dynamic steady states of the yeast metabolome. Metabolic engineering 20070101
Comparison of S-Adenosyl-L-methionine and N-acetylcysteine protective effects on acetaminophen hepatic toxicity. The Journal of pharmacology and experimental therapeutics 20070101
Binding study of AfsK, a Ser/Thr kinase from Streptomyces coelicolor A3(2) and S-adenosyl-L-methionine. FEMS microbiology letters 20070101
Allosteric monofunctional aspartate kinases from Arabidopsis. The FEBS journal 20070101
Amino acids and the regulation of methyl balance in humans. Current opinion in clinical nutrition and metabolic care 20070101
Emerging aspects of gut sulfur amino acid metabolism. Current opinion in clinical nutrition and metabolic care 20070101
The role of methionine recycling for ethylene synthesis in Arabidopsis. The Plant journal : for cell and molecular biology 20070101
Cysteine supplementation decreases plasma homocysteine concentration in rats fed on a low-casein diet in rats. Bioscience, biotechnology, and biochemistry 20070101
Crystal structures of CbiL, a methyltransferase involved in anaerobic vitamin B biosynthesis, and CbiL in complex with S-adenosylhomocysteine--implications for the reaction mechanism. The FEBS journal 20070101
A method to study the expression of DNA methyltransferases in aging systems in vitro. Methods in molecular biology (Clifton, N.J.) 20070101
The role of one-carbon metabolism in schizophrenia and depression. Harvard review of psychiatry 20070101
Effects of dietary supplementation with N-acetyl cysteine, acetyl-L-carnitine and S-adenosyl methionine on cognitive performance and aggression in normal mice and mice expressing human ApoE4. Neuromolecular medicine 20070101
Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clinical chemistry and laboratory medicine 20070101
Wheat endonuclease WEN1 dependent on S-adenosyl-L-methionine and sensitive to DNA methylation status. Epigenetics 20070101
Hydroxyl radical probing of tRNA (Gm18) methyltransferase [TrmH]-AdoMet-artificial tRNA ternary complex. Nucleic acids symposium series (2004) 20070101
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC biochemistry 20070101
Potentiation of arsenic neurotoxicity by folate deprivation: protective role of S-adenosyl methionine. Nutritional neuroscience 20070101
Priorities in the discovery of the implications of water channels in epilepsy and Duchenne muscular dystrophy. Cellular and molecular biology (Noisy-le-Grand, France) 20061231
Catalysis in glycine N-methyltransferase: testing the electrostatic stabilization and compression hypothesis. Biochemistry 20061219
Nitric oxide modulates glutathione synthesis during endotoxemia. Free radical biology & medicine 20061215
Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20061205
Protein arginine methylation: Cellular functions and methods of analysis. Biochimica et biophysica acta 20061201
Suppression of TNF-alpha production by S-adenosylmethionine in human mononuclear leukocytes is not mediated by polyamines. Biological chemistry 20061201
S-adenosylmethionine (SAM)-accumulating sake yeast suppresses acute alcohol-induced liver injury in mice. Bioscience, biotechnology, and biochemistry 20061201
Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. The Plant cell 20061201
Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress. Journal of Alzheimer's disease : JAD 20061201
Increase in S-adenosylhomocysteine content and its effect on the S-adenosylhomocysteine hydrolase activity under transient high plasma homocysteine levels in rats. Journal of nutritional science and vitaminology 20061201
Quantitative analysis of s-adenosylmethionine and s-adenosylhomocysteine in neurulation-stage mouse embryos by liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061121
Structural basis for the differential regulation of DNA by the methionine repressor MetJ. The Journal of biological chemistry 20061110
Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes. The Journal of biological chemistry 20061110
DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione. Biochemical and biophysical research communications 20061110
Mild folate deficiency induces a proatherosclerotic phenotype in endothelial cells. Atherosclerosis 20061101
S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. American journal of physiology. Gastrointestinal and liver physiology 20061101
Molecular identification of an Arabidopsis S-adenosylmethionine transporter. Analysis of organ distribution, bacterial expression, reconstitution into liposomes, and functional characterization. Plant physiology 20061101
Arabidopsis SAMT1 defines a plastid transporter regulating plastid biogenesis and plant development. The Plant cell 20061101
PAGE separation of hemi-methylated or unmethylated oligonucleotide substrates to distinguish between maintenance and de novo DNA methyltranferase activity. Journal of biochemical and biophysical methods 20061031
Tandem riboswitch architectures exhibit complex gene control functions. Science (New York, N.Y.) 20061013
Interactions of cytokines, S-Adenosylmethionine, and S-Adenosylhomocysteine in alcohol-induced liver disease and immune suppression. Journal of gastroenterology and hepatology 20061001
L-NAME has opposite effects on the productions of S-adenosylhomocysteine and S-adenosylmethionine in V12-H-Ras and M-CR3B-Ras pheochromocytoma cells. Neurochemical research 20061001
Solvent-accessible cysteines in human cystathionine beta-synthase: crucial role of cysteine 431 in S-adenosyl-L-methionine binding. Biochemistry 20060912
Characterization of an active spore photoproduct lyase, a DNA repair enzyme in the radical S-adenosylmethionine superfamily. The Journal of biological chemistry 20060908
Exogenous glycine partially attenuates homocysteine-induced apoptosis and membrane peroxidation in chick embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060901
Osteoarthritis. Disease-a-month : DM 20060901
4-Hydroxyphenylacetate decarboxylases: properties of a novel subclass of glycyl radical enzyme systems. Biochemistry 20060808
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man. Journal of inherited metabolic disease 20060801
S-Adenosyl-L-methionine: beyond the universal methyl group donor. Phytochemistry 20060801
Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats. Bioscience, biotechnology, and biochemistry 20060801
Folate, the methionine cycle, and Alzheimer's disease. Journal of Alzheimer's disease : JAD 20060801
Dietary and genetically-induced oxidative stress alter tau phosphorylation: influence of folate and apolipoprotein E deficiency. Journal of Alzheimer's disease : JAD 20060801
Gene silencing through methylation: an epigenetic intervention on Alzheimer disease. Journal of Alzheimer's disease : JAD 20060801
The effect of S-adenosylmethionine on CNS gene expression studied by cDNA microarray analysis. Journal of Alzheimer's disease : JAD 20060801
Homocysteine metabolism and various consequences of folate deficiency. Journal of Alzheimer's disease : JAD 20060801
Crystal structures of BchU, a methyltransferase involved in bacteriochlorophyll c biosynthesis, and its complex with S-adenosylhomocysteine: implications for reaction mechanism. Journal of molecular biology 20060721
Flipping off the riboswitch: RNA structures that control gene expression. ACS chemical biology 20060721
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Gastroenterology 20060701
Structural biology: RNA switches function. Nature 20060629
Structure of the S-adenosylmethionine riboswitch regulatory mRNA element. Nature 20060629
Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. Biochemistry 20060620
Differential regulation of the JNK/AP-1 pathway by S-adenosylmethionine and methylthioadenosine in primary rat hepatocytes versus HuH7 hepatoma cells. American journal of physiology. Gastrointestinal and liver physiology 20060601
Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans. The Journal of antimicrobial chemotherapy 20060601
Tolcapone decreases plasma levels of S-adenosyl-L-homocysteine and homocysteine in treated Parkinson's disease patients. European journal of clinical pharmacology 20060601
In vivo hydrolysis of S-adenosyl-L-methionine in Escherichia coli increases export of 5-methylthioribose. Canadian journal of microbiology 20060601
The active conformation of avilamycin A is conferred by AviX12, a radical AdoMet enzyme. The Journal of biological chemistry 20060526
S-adenosylmethionine but not glutathione protects against galactosamine-induced cytotoxicity in rat hepatocyte cultures. Toxicology 20060515
Coupling between protein and reaction dynamics in enzymatic processes: application of Grote-Hynes Theory to catechol O-methyltransferase. Journal of the American Chemical Society 20060510
Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. American journal of physiology. Endocrinology and metabolism 20060501
Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome? American journal of medical genetics. Part A 20060501
In vivo hydrolysis of S-adenosylmethionine induces the met regulon of Escherichia coli. Microbiology (Reading, England) 20060501
Determinants of the ubiquitin-mediated degradation of the Met4 transcription factor. The Journal of biological chemistry 20060428
Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus. Journal of molecular biology 20060428
S-adenosyl-L-methionine for alcoholic liver diseases. The Cochrane database of systematic reviews 20060419
Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells. American journal of physiology. Gastrointestinal and liver physiology 20060401
S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice. The Journal of pharmacology and experimental therapeutics 20060401
S-adenosylmethionine: jack of all trades and master of everything? Biochemical Society transactions 20060401
S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro. Hepatology (Baltimore, Md.) 20060401
Spectral and kinetic characterization of 7,8-diaminopelargonic acid synthase from Mycobacterium tuberculosis. IUBMB life 20060401
S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism. World journal of gastroenterology 20060328
An enzyme-coupled continuous spectrophotometric assay for S-adenosylmethionine-dependent methyltransferases. Analytical biochemistry 20060315
Cofactor dependence of reduction potentials for [4Fe-4S]2+/1+ in lysine 2,3-aminomutase. Biochemistry 20060314
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis. Biochemistry 20060314
Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine. Journal of the American Chemical Society 20060308
Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. Journal of hepatology 20060301
DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction. Liver international : official journal of the International Association for the Study of the Liver 20060301
Let LuxS speak up in AI-2 signaling. Trends in microbiology 20060301
Therapy of NAFLD: antioxidants and cytoprotective agents. Journal of clinical gastroenterology 20060301
[Effect of feeding pre-L-methionine on high-cell-density fermentation for S-adenosyl-L-methionine production]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20060301
Differential effects of dietary selenium (se) and folate on methyl metabolism in liver and colon of rats. Biological trace element research 20060301
[Ursodeoxycholic acid, S-adenosyl-L-methionine and their combinations in the treatment of gestational intrahepatic cholestasis (ICP)]. Ceska gynekologie 20060301
[The impact of heptral, vitamin B6 and folic acid on the indices of hepatic biotransformation in toxic hepatitis]. Georgian medical news 20060301
Allosteric threonine synthase. Reorganization of the pyridoxal phosphate site upon asymmetric activation through S-adenosylmethionine binding to a novel site. The Journal of biological chemistry 20060224
The 108M polymorph of human catechol O-methyltransferase is prone to deformation at physiological temperatures. Biochemistry 20060221
Synergistic protection by S-adenosylmethionine with vitamins C and E on liver injury induced by thioacetamide in rats. Free radical biology & medicine 20060215
A new method for isolation of S-adenosylmethionine (SAM)-accumulating yeast. Applied microbiology and biotechnology 20060201
Flavonoid 3'-O-methyltransferase from rice: cDNA cloning, characterization and functional expression. Phytochemistry 20060201
The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine. Molecular microbiology 20060201
Complementary medicines in psychiatry: review of effectiveness and safety. The British journal of psychiatry : the journal of mental science 20060201
The fluorinase from Streptomyces cattleya is also a chlorinase. Angewandte Chemie (International ed. in English) 20060123
Activation of a novel isoform of methionine adenosyl transferase 2A and increased S-adenosylmethionine turnover in lung epithelial cells exposed to hyperoxia. Free radical biology & medicine 20060115
Characterization of a methionine adenosyltransferase over-expressing strain in the trypanosomatid Leishmania donovani. Biochimica et biophysica acta 20060101
Protective effect of S-adenosylmethionine against galactosamine-induced injury of rat hepatocytes in primary culture. Physiological research 20060101
Quantification of S-adenosyl methionine in microbial cell extracts. Biotechnology letters 20060101
Chemical expansion of cofactor activity. Nature chemical biology 20060101
Glutathione-enhancing agents protect against steatohepatitis in a dietary model. Journal of biochemical and molecular toxicology 20060101
Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood? BioFactors (Oxford, England) 20060101
Radical enzymes in anaerobes. Annual review of microbiology 20060101
Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. Journal of perinatal medicine 20060101
S-adenosylmethionine or 5'-methylthioadenosine are unable to prevent fumonisin B1 hepatotoxicity in mice despite increased oxidation in liver. Journal of applied toxicology : JAT 20060101
Effect of cell cycle growth arrest on global DNA methylation status in human lung epithelial-like (A549) cells. In vivo (Athens, Greece) 20060101
Structural studies of the purine and SAM binding riboswitches. Cold Spring Harbor symposia on quantitative biology 20060101
Synthesis of S-adenosyl-L-methionine analogs and their use for sequence-specific transalkylation of DNA by methyltransferases. Nature protocols 20060101
The role of nutritional therapy in alcoholic liver disease. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 20060101
Aspirin augments the concentration of endogenous hydrogen sulfide in mouse brain and liver. Folia medica Cracoviensia 20060101
Procainamide is a specific inhibitor of DNA methyltransferase 1. The Journal of biological chemistry 20051209
Inclusion of thiamine diphosphate and S-adenosylmethionine at their chemically active sites. The Journal of organic chemistry 20051209
The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. Neurotoxicology 20051201
In vitro and in vivo analysis of the major type I protein arginine methyltransferase from Trypanosoma brucei. Molecular and biochemical parasitology 20051201
The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii. Protein science : a publication of the Protein Society 20051201
The immediate-early ethylene response gene OsARD1 encodes an acireductone dioxygenase involved in recycling of the ethylene precursor S-adenosylmethionine. The Plant journal : for cell and molecular biology 20051201
Inhibitory effect of Epimedium extract on S-adenosyl-L-homocysteine hydrolase and biomethylation. Life sciences 20051126
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase. Journal of medicinal chemistry 20051117
A deficiency in S-adenosylmethionine synthetase interrupts assembly of the septal ring in Escherichia coli K-12. Molecular microbiology 20051101
Sequence specificity and role of proximal amino acids of the histone H3 tail on catalysis of murine G9A lysine 9 histone H3 methyltransferase. Biochemistry 20051004
Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers. American journal of physiology. Renal physiology 20051001
Structural and functional comparison of HemN to other radical SAM enzymes. Biological chemistry 20051001
The transmethylation cycle in the brain of Alzheimer patients. Neuroscience letters 20050930
An escape from Italy, the discovery of S-adenosylmethionine, and the biosynthesis of creatine by Giulio L. Cantoni. 1953. The Journal of biological chemistry 20050923
Biochemical characterization of the HydE and HydG iron-only hydrogenase maturation enzymes from Thermatoga maritima. FEBS letters 20050912
Protective effect of S-adenosylmethionine on cellular and mitochondrial membranes of rat hepatocytes against tert-butylhydroperoxide-induced injury in primary culture. Chemico-biological interactions 20050910
S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. The Journal of biological chemistry 20050902
Exogenous AdoMet and its analogue sinefungin differentially influence DNA cleavage by R.EcoP15I--usefulness in SAGE. Biochemical and biophysical research communications 20050902
Diet-dependent survival of protein repair-deficient mice. The Journal of nutritional biochemistry 20050901
Paracoccidioides brasiliensis, paracoccidioidomycosis, and antifungal antibiotics. Current drug targets. Infectious disorders 20050901
A Leptospira interrogans enzyme with similarity to yeast Ste14p that methylates the 1-phosphate group of lipid A. The Journal of biological chemistry 20050826
Radical S-adenosylmethionine enzyme coproporphyrinogen III oxidase HemN: functional features of the [4Fe-4S] cluster and the two bound S-adenosyl-L-methionines. The Journal of biological chemistry 20050812
Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma. Clinical chemistry 20050801
Tyr152 plays a central role in the catalysis of 1-aminocyclopropane-1-carboxylate synthase. Journal of experimental botany 20050801
Unusual pseudosubstrate specificity of a novel 3,5-dimethoxyphenol O-methyltransferase cloned from Ruta graveolens L. Archives of biochemistry and biophysics 20050801
In nucleo enzymatic assays for the identification and characterization of histone modifying activities. Methods (San Diego, Calif.) 20050801
A tertiary structural element in S box leader RNAs is required for S-adenosylmethionine-directed transcription termination. Molecular microbiology 20050801
Structure of a class II TrmH tRNA-modifying enzyme from Aquifex aeolicus. Acta crystallographica. Section F, Structural biology and crystallization communications 20050801
o-nitrobenzenesulfonamides in nucleoside synthesis: efficient 5'-aziridination of adenosine. The Journal of organic chemistry 20050722
DNA cytosine C5 methyltransferase Dnmt1: catalysis-dependent release of allosteric inhibition. Biochemistry 20050712
Removing a bottleneck in the Bacillus subtilis biotin pathway: bioA utilizes lysine rather than S-adenosylmethionine as the amino donor in the KAPA-to-DAPA reaction. Biotechnology and bioengineering 20050705
Stable isotope dilution-based accurate comparative quantification of nitrogen-containing metabolites in Arabidopsis thaliana T87 cells using in vivo (15)N-isotope enrichment. Bioscience, biotechnology, and biochemistry 20050701
Effects of betaine supplementation on hepatic metabolism of sulfur-containing amino acids in mice. Journal of hepatology 20050601
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction? Reproductive biomedicine online 20050601
[Effect of heptral and folic acid on the hepatic functions during toxic hepatitis]. Georgian medical news 20050601
Hepatic S-adenosylmethionine after maternal alcohol exposure on offspring rats. Addiction biology 20050601
Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis. The Journal of biological chemistry 20050527
Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase. Biochemistry 20050503
Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes. Clinical chemistry 20050501
Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alpha-naphthylisothiocyanate. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050501
Expression of iron-acquisition-related genes in iron-deficient rice is co-ordinately induced by partially conserved iron-deficiency-responsive elements. Journal of experimental botany 20050501
Antioxidants as novel therapy in a murine model of colitis. The Journal of nutritional biochemistry 20050501
Mechanistic studies on the metabolic scission of thiazolidinedione derivatives to acyclic thiols. Chemical research in toxicology 20050501
Kinetics of homocysteine metabolism after moderate alcohol consumption. Alcoholism, clinical and experimental research 20050501
S-adenosyl-L-methionine: transcellular transport and uptake by Caco-2 cells and hepatocytes. The Journal of pharmacy and pharmacology 20050501
Effect of nicotine on lung S-adenosylmethionine and development of Pneumocystis pneumonia. The Journal of biological chemistry 20050415
The impact of metabolism on DNA methylation. Human molecular genetics 20050415
S-adenosylmethionine (SAMe) modulates interleukin-10 and interleukin-6, but not TNF, production via the adenosine (A2) receptor. Biochimica et biophysica acta 20050415
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life sciences 20050408
Polyamine synthesis from proline in the developing porcine placenta. Biology of reproduction 20050401
In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway. The Journal of biological chemistry 20050401
mRNA guanylation catalyzed by the S-adenosylmethionine-dependent guanylyltransferase of bamboo mosaic virus. The Journal of biological chemistry 20050401
S-adenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study. Arteriosclerosis, thrombosis, and vascular biology 20050401
Residues distal from the active site that alter enzyme function in M.HhaI DNA cytosine methyltransferase. Journal of biomolecular structure & dynamics 20050401
Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochemical pharmacology 20050401
Regulation of trehalose metabolism by Adox and AdoMet in Saccharomyces cerevisiae. Indian journal of experimental biology 20050401
Effect of fasting on methionine adenosyltransferase expression and the methionine cycle in the mouse liver. Journal of nutritional science and vitaminology 20050401
Alcohol and liver cancer. Alcohol (Fayetteville, N.Y.) 20050401
Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer. Alcohol (Fayetteville, N.Y.) 20050401
Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide. Journal of the American Chemical Society 20050309
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. Neurology 20050308
Relationship between S-adenosylmethionine, S-adenosylhomocysteine, asymmetric dimethylarginine, and endothelial function in healthy human subjects during experimental hyper- and hypohomocysteinemia. Metabolism: clinical and experimental 20050301
Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biological psychiatry 20050301
Effect of piroxicam, metamizol, and S-adenosylmethionine in a murine model of experimental trichomoniasis. Parasite (Paris, France) 20050301
Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). The Journal of biological chemistry 20050211
Effect of S-adenosyl-L-methionine on the activation, proliferation and contraction of hepatic stellate cells. European journal of pharmacology 20050210
Aclacinomycin 10-hydroxylase is a novel substrate-assisted hydroxylase requiring S-adenosyl-L-methionine as cofactor. The Journal of biological chemistry 20050204
Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis. Carcinogenesis 20050201
Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer research 20050201
Evaluation of the influence of S-adenosylmethionine on systemic and hepatic effects of prednisolone in dogs. American journal of veterinary research 20050201
Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology 20050101
Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability. Pediatric research 20050101
Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation. Archives of biochemistry and biophysics 20050101
The novel structure and chemistry of iron-sulfur clusters in the adenosylmethionine-dependent radical enzyme biotin synthase. Archives of biochemistry and biophysics 20050101
S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Molecular and cellular neurosciences 20050101
Autotoxicity, methylation and a road to the prevention of Parkinson's disease. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20050101
The effect of methionine and S-adenosylmethionine on S-adenosylmethionine levels in the rat brain. Journal of psychiatry & neuroscience : JPN 20050101
The role of cystathionine beta-synthase in homocysteine metabolism. Antioxidants & redox signaling 20050101
Nonpharmacologic treatments for depression in patients with coronary heart disease. Psychosomatic medicine 20050101
The effects of S-adenosylmethionine on clinical pathology and redox potential in the red blood cell, liver, and bile of clinically normal cats. Journal of veterinary internal medicine 20050101
S-adenosylhomocysteine metabolism in different cell lines: effect of hypoxia and cell density. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20050101
Evidence for a second class of S-adenosylmethionine riboswitches and other regulatory RNA motifs in alpha-proteobacteria. Genome biology 20050101
Natural history of S-adenosylmethionine-binding proteins. BMC structural biology 20050101
Levodopa intake increases plasma levels of S-adenosylmethionine in treated patients with Parkinson disease. Clinical neuropharmacology 20050101
Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years. Roczniki Akademii Medycznej w Bialymstoku (1995) 20050101
Effect of S-adenosylmethionine on age-induced hepatocyte damage in old Wistar rats. Biogerontology 20050101
Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues. Nucleic acids symposium series (2004) 20050101
S-Adenosylmethionine (SAMe) attenuates acetaminophen hepatotoxicity in C57BL/6 mice. Toxicology letters 20041230
Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe). Cytokine 20041221
Salt stress enhances xylem development and expression of S-adenosyl-L-methionine synthase in lignifying tissues of tomato plants. Planta 20041201
S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine. Journal of clinical psychopharmacology 20041201
Bacteriophage T4Dam DNA-(adenine-N(6))-methyltransferase. Comparison of pre-steady state and single turnover methylation of 40-mer duplexes containing two (un)modified target sites. The Journal of biological chemistry 20041126
MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA. The Journal of biological chemistry 20041112
Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy 20041101
Modulation of methyl group metabolism by streptozotocin-induced diabetes and all-trans-retinoic acid. The Journal of biological chemistry 20041029
Insight into the polar reactivity of the onium chalcogen analogues of S-adenosyl-L-methionine. Biochemistry 20041026
Isotope and elemental effects indicate a rate-limiting methyl transfer as the initial step in the reaction catalyzed by Escherichia coli cyclopropane fatty acid synthase. Biochemistry 20041026
DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene 20041014
Treatment of AIDS-associated myelopathy with L-methionine: a placebo-controlled study. Neurology 20041012
SAM domains can utilize similar surfaces for the formation of polymers and closed oligomers. Journal of molecular biology 20041001
S-adenosylmethionine radical enzymes. Bioorganic chemistry 20041001
Structure and function of radical SAM enzymes. Current opinion in chemical biology 20041001
Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone. Biochemistry 20040928
Mutational analysis of ThiH, a member of the radical S-adenosylmethionine (AdoMet) protein superfamily. The Journal of biological chemistry 20040924
Escherichia coli lipoyl synthase binds two distinct [4Fe-4S] clusters per polypeptide. Biochemistry 20040921
Widespread activation of antibiotic biosynthesis by S-adenosylmethionine in streptomycetes. FEMS microbiology letters 20040915
The mechanism of target base attack in DNA cytosine carbon 5 methylation. Biochemistry 20040914
Fusarin C biosynthesis in Fusarium moniliforme and Fusarium venenatum. Chembiochem : a European journal of chemical biology 20040906
S-adenosylmethionine protects against intrabiliary glutathione degradation induced by long-term administration of cyclosporin A in the rat. Toxicology 20040901
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases. Drug metabolism and disposition: the biological fate of chemicals 20040901
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)-phenyl] methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. II. Identification of metabolites by liquid chromatography-tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals 20040901
N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. The Journal of biological chemistry 20040827
S-adenosylmethionine and Pneumocystis. FEMS microbiology letters 20040815
Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase. Behavioural brain research 20040812
Differential protein expression analysis of Leishmania major reveals novel roles for methionine adenosyltransferase and S-adenosylmethionine in methotrexate resistance. The Journal of biological chemistry 20040806
Stopped-flow and mutational analysis of base flipping by the Escherichia coli Dam DNA-(adenine-N6)-methyltransferase. Journal of molecular biology 20040806
Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. American journal of physiology. Gastrointestinal and liver physiology 20040801
Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro. Bioorganic chemistry 20040801
S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice. Pharmacology 20040801
Autoregulation of the gene for cystathionine gamma-synthase in Arabidopsis: post-transcriptional regulation induced by S-adenosylmethionine. Biochemical Society transactions 20040801
Homocysteine clearance and methylation flux rates in health and end-stage renal disease: association with S-adenosylhomocysteine. American journal of physiology. Renal physiology 20040801
Nutrition and alcoholic liver disease. Seminars in liver disease 20040801
How oligomerization contributes to the thermostability of an archaeon protein. Protein L-isoaspartyl-O-methyltransferase from Sulfolobus tokodaii. The Journal of biological chemistry 20040730
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Mapping and molecular modeling of S-adenosyl-L-methionine binding sites in N-methyltransferase domains of the multifunctional polypeptide cyclosporin synthetase. The Journal of biological chemistry 20030110
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Characterization of human soluble high and low activity catechol-O-methyltransferase catalyzed catechol estrogen methylation. Pharmacogenetics 20021001
An essential role of s-adenosyl-L-methionine:L-methionine s-methyltransferase in selenium volatilization by plants. Methylation of selenomethionine to selenium-methyl-L-selenium- methionine, the precursor of volatile selenium. Plant physiology 20021001
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A stereospecific colorimetric assay for (S,S)-adenosylmethionine quantification based on thiopurine methyltransferase-catalyzed thiol methylation. Analytical biochemistry 20020915
Visualizing central effects of S-adenosyl-L-methionine (SAMe), a natural molecule with antidepressant properties, by pharmaco-EEG mapping. The international journal of neuropsychopharmacology 20020901
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