Home Carboxys potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate

CAS No.:
61177-45-5
Catalog Number:
AG0035ID
Molecular Formula:
C8H8KNO5
Molecular Weight:
237.2511
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
96%
In Stock USA
United States
$63
- +
5g
96%
In Stock USA
United States
$188
- +
10g
96%
In Stock USA
United States
$313
- +
25g
96%
In Stock USA
United States
$600
- +
Product Description
Catalog Number:
AG0035ID
Chemical Name:
potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
CAS Number:
61177-45-5
Molecular Formula:
C8H8KNO5
Molecular Weight:
237.2511
MDL Number:
MFCD01710901
IUPAC Name:
potassium;(2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
InChI:
InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
InChI Key:
ABVRVIZBZKUTMK-JSYANWSFSA-M
SMILES:
[O-]C(=O)[C@@H]1N2[C@H](O/C/1=C\CO)CC2=O.[K+]
EC Number:
262-640-9
UNII:
Q42OMW3AT8
Properties
Complexity:
329  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Exact Mass:
237.004g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
237.252g/mol
Monoisotopic Mass:
237.004g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
89.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
In vitro and in vivo efficacy of β-lactams against replicating and slowly growing/nonreplicating Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy 20130601
Mecillinam/clavulanate combination: a possible option for the treatment of community-acquired uncomplicated urinary tract infections caused by extended-spectrum β-lactamase-producing Escherichia coli. The Journal of antimicrobial chemotherapy 20121001
Novel fragments of clavulanate observed in the structure of the class A β-lactamase from Bacillus licheniformis BS3. The Journal of antimicrobial chemotherapy 20121001
Clavulanic acid inhibits MPP⁺-induced ROS generation and subsequent loss of dopaminergic cells. Brain research 20120821
Shear conditions in clavulanic acid production by Streptomyces clavuligerus in stirred tank and airlift bioreactors. Bioprocess and biosystems engineering 20120801
The use of amoxicillin and clavulanic acid and quinolones as first choice antibiotics in uncomplicated urinary tract infections in Spain should be reviewed. Atencion primaria 20120701
Randomized controlled trial of antibiotic prophylaxis regimens for transrectal ultrasound-guided prostate biopsy. Chinese medical journal 20120701
[Detection of plasmid-mediated AmpC beta-lactamase in clinical isolates of cefoxitin-resistant Escherichia coli and Klebsiella pneumoniae]. Mikrobiyoloji bulteni 20120701
Mycetoma caused by Nocardia yamanashiensis, Papua New Guinea. The American journal of tropical medicine and hygiene 20120601
[Determination of clavulanic acid residue in milk by high performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography 20120601
Comparison of adherence between twice- and thrice-daily regimens of oral amoxicillin/clavulanic acid. Respirology (Carlton, Vic.) 20120501
Primary sternal osteomyelitis due to Peptostreptococcus anaerobius. Infection 20120401
Clinical use of the meropenem-clavulanate combination for extensively drug-resistant tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20120401
Antibiotic treatment for uncomplicated acute appendicitis. Lancet (London, England) 20120331
Mechanism of resistance of a highly carbapenem-resistant Klebsiella oxytoca isolate and comparison of susceptibility to five carbapenems. International journal of antimicrobial agents 20120301
Sunitinib related osteonecrosis of jaw: a case report. Oral surgery, oral medicine, oral pathology and oral radiology 20120301
Separation of clavulanic acid from fermented broth of amino acids by an aqueous two-phase system and ion-exchange adsorption. New biotechnology 20120215
Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples. Science China. Life sciences 20120201
New definitions of extended-spectrum β-lactamase conferring worldwide emerging antibiotic resistance. Medicinal research reviews 20120101
Clavulanic acid does not affect convulsions in acute seizure tests in mice. Journal of neural transmission (Vienna, Austria : 1996) 20120101
Is amoxicillin plus clavulanic acid non-inferior to appendicectomy for the treatment of uncomplicated acute appendicitis? Internal and emergency medicine 20111201
Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking. Neuroscience letters 20111024
Penile paraffinoma developing during treatment with pegylated interferon alfa-2a for chronic hepatitis C virus infection. Archives of dermatology 20111001
In vitro synergistic interaction of 5-O-methylglovanon and ampicillin against ampicillin resistant Staphylococcus aureus and Staphylococcus epidermidis isolates. Archives of pharmacal research 20111001
Antibiotics versus surgery for appendicitis. Lancet (London, England) 20110917
Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis. The Pediatric infectious disease journal 20110901
False extended-spectrum {beta}-lactamase phenotype in clinical isolates of Escherichia coli associated with increased expression of OXA-1 or TEM-1 penicillinases and loss of porins. The Journal of antimicrobial chemotherapy 20110901
Genetic characterization of the mechanisms of resistance to amoxicillin/clavulanate and third-generation cephalosporins in Salmonella enterica from three Spanish hospitals. International microbiology : the official journal of the Spanish Society for Microbiology 20110901
Antimicrobial susceptibility of Listeria monocytogenes food isolates from different cities in Colombia. Foodborne pathogens and disease 20110801
Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus. Molecular microbiology 20110801
Role of σ-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585. Microbiological research 20110720
Augmentation in zone of inhibition of cefoperazone/cefoperazone+ sulbactum compares well with the clinical laboratory standard institute standard extended spectrum beta-lactamase detection method as well as the polymerase chain reaction method. Current drug safety 20110701
Emergence and dominance of CTX-M-15 extended spectrum beta-lactamase among Escherichia coli isolates from children. Microbial drug resistance (Larchmont, N.Y.) 20110601
Characterization of multidrug-resistant Escherichia coli by antimicrobial resistance profiles, plasmid replicon typing, and pulsed-field gel electrophoresis. Microbial drug resistance (Larchmont, N.Y.) 20110601
Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes. Biotechnology letters 20110601
On the efficacy of penicillins for Helicobacter pylori eradication. Panminerva medica 20110601
[Simultaneous determination of serum concentrations of amoxicillin and clavulanate potassium in human blood using high-performance liquid chromatography]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20110601
Antimicrobial susceptibility of Actinobacillus pleuropneumoniae isolates from clinical outbreaks of porcine respiratory diseases. Veterinary microbiology 20110512
Amoxicillin plus clavulanic acid versus appendicectomy for treatment of acute uncomplicated appendicitis: an open-label, non-inferiority, randomised controlled trial. Lancet (London, England) 20110507
Estimation of the clinical and economic consequences of non-compliance with antimicrobial treatment of canine skin infections. Preventive veterinary medicine 20110501
Lingua villosa nigra. Lancet (London, England) 20110402
Stevens-Johnson syndrome and cholestatic hepatitis induced by acute Epstein-Barr virus infection. European journal of gastroenterology & hepatology 20110301
A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production. Microbial biotechnology 20110301
Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus. Microbial biotechnology 20110301
Retinal vasoproliferative granulomatous lesion associated with hand pyoderma caused by Streptococcus pyogenes. Ocular immunology and inflammation 20110201
Nicolau syndrome after lidocaine injection and cold application: a rare complication of breast core needle biopsy. International journal of dermatology 20110101
Extractive fermentation of clavulanic acid by Streptomyces DAUFPE 3060 using aqueous two-phase system. Biotechnology progress 20110101
Antibiotic prophylaxis and early dental implant failure: a quasi-random controlled clinical trial. European journal of oral implantology 20110101
Transient hyperthyroidism due to acute suppurative thyroiditis in an adolescent female. Journal of pediatric endocrinology & metabolism : JPEM 20110101
Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol. BMC pulmonary medicine 20110101
[Update on current care guidelines: antimicrobials in acute dentistry]. Duodecim; laaketieteellinen aikakauskirja 20110101
Comparison of the boronic acid disk potentiation test and cefepime-clavulanic acid method for the detection of ESBL among AmpC-producing Enterobacteriaceae. Indian journal of medical microbiology 20110101
[Aspects of the antimicrobial resistence profile in infections with Escherichia coli and Klebsiella pneumoniae in diabetic patients]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20110101
[Susceptibility of Klebsiella oxytoca to selected antibiotics]. Medycyna doswiadczalna i mikrobiologia 20110101
A prospective study of cefepime versus ticarcilline/clavulanate as empirical treatment of febrile neutropenia in lymphoma patients. JPMA. The Journal of the Pakistan Medical Association 20110101
Prospective randomized clinical trial assessing the efficacy of a short course of intravenously administered amoxicillin plus clavulanic acid followed by oral antibiotic in patients with uncomplicated acute diverticulitis. International journal of colorectal disease 20101101
Activity of BAL30376 (monobactam BAL19764 + BAL29880 + clavulanate) versus Gram-negative bacteria with characterized resistance mechanisms. The Journal of antimicrobial chemotherapy 20101101
[Simultaneous determination of amoxicillin and clavulanic acid in the human plasma by high performance liquid chromatography-mass spectrometry (UPLC/MS)]. Vojnosanitetski pregled 20101101
Impact of restricted amoxicillin/clavulanic acid use on Escherichia coli resistance--antibiotic DU90% profiles with bacterial resistance rates: a visual presentation. International journal of antimicrobial agents 20101001
Clavulanic acid biosynthesis and genetic manipulation for its overproduction. Applied microbiology and biotechnology 20101001
Experience with patients with anti-MUSK antibody positive myasthenia gravis. The Journal of the Association of Physicians of India 20101001
Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant. Microbiology (Reading, England) 20100801
Eyelid abscess arising from an epidermal inclusion cyst. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20100729
Selective allergic reactions to clavulanic acid: a report of 9 cases. The Journal of allergy and clinical immunology 20100701
Simultaneous chemiluminescence determination of amoxicillin and clavulanic acid using least squares support vector regression. Analytica chimica acta 20100618
Species distribution and antimicrobial susceptibility of staphylococci isolated from canine otitis externa. Veterinary dermatology 20100601
[Oral antibiotics for non-Hodgkin's lymphoma patients with low risk neutropenic fever--a comparative controlled study]. Harefuah 20100601
Successful resolution of pneumonia developed in a patient affected by Crohn's disease, rheumatoid arthritis, myasthenia gravis and recurrent uveitis during concomitant treatment with tumour necrosis factor alpha inhibitors and conventional immunosuppressive drugs. Rheumatology international 20100501
Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway. Proteins 20100501
Neonatal intrauterine infection with Neisseria meningitidis B. Clinical pediatrics 20100401
Screening of variables influencing the clavulanic acid production by Streptomyces DAUFPE 3060 strain. Applied biochemistry and biotechnology 20100301
Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid. Journal of molecular biology 20100219
Beta-lactamase inhibitory component from the roots of Fissistigma cavaleriei. Phytomedicine : international journal of phytotherapy and phytopharmacology 20100201
Clavulanic acid can be the component in amoxicillin-clavulanic acid responsible for immediate hypersensitivity reactions. The Journal of allergy and clinical immunology 20100201
Removal of potassium chloride by nanofiltration from ion-exchanged solution containing potassium clavulanate. Bioprocess and biosystems engineering 20100101
You're the flight surgeon: diverticulitis. Aviation, space, and environmental medicine 20100101
In vitro killing activity of crevicular concentrations of tinidazole plus common oral antibiotics against high-density mixed inocula of periodontal pathogens in strict anaerobic conditions. Journal of periodontology 20100101
Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585. Journal of microbiology and biotechnology 20100101
Clinical experience with spiramycin in bisphosphonate-associated osteonecrosis of the jaw. International journal of immunopathology and pharmacology 20100101
The Pott's puffy tumor: an unusual complication of frontal sinusitis, methods for its detection. Pediatric dermatology 20100101
Miniaturized fluid array for high-throughput protein expression. Biotechnology progress 20100101
[Chromogenic medium for detection of enterobacteria producing beta-lactamases in North-Eastern Romania]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101
Prophylactic antibiotics in endoscopic sinus surgery: a short follow-up study. American journal of rhinology & allergy 20100101
[Management of cervical cellulitis with and without mediastinal extension: report of 17 cases]. Revue de laryngologie - otologie - rhinologie 20100101
Antibiotic prescription for the treatment of endodontic pathology: a survey among Lithuanian dentists. Medicina (Kaunas, Lithuania) 20100101
[Bacterial enteric pathogens' resistance to fluoroquinolones and last generation cephalosporines]. Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990) 20100101
Use of the cefepime-clavulanate ESBL Etest for detection of extended-spectrum beta-lactamases in AmpC co-producing bacteria. Journal of infection in developing countries 20091121
Efficacy and safety of sequential intravenous/oral moxifloxacin vs intravenous/oral amoxicillin/clavulanate for complicated skin and skin structure infections. Infection 20091001
[Retro- and parapharyngeal infections: standardization of their management]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20090901
Two cases of Stevens-Johnson syndrome following intake of klavox with review of literature. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20090801
Efficacy of the standard quadruple therapy versus triple therapies containing proton pump inhibitor plus amoxicillin and clarithromycin or amoxicillin-clavulanic acid and metronidazole for Helicobacter pylori eradication in children. Digestive diseases and sciences 20090801
Evaluation of the effects of the parameters involved in the purification of clavulanic acid from fermentation broth by aqueous two-phase systems. Bioprocess and biosystems engineering 20090801
Clavulanic acid: a competitive inhibitor of beta-lactamases with novel anxiolytic-like activity and minimal side effects. Pharmacology, biochemistry, and behavior 20090801
Kounis syndrome secondary to amoxicillin/clavulanic acid use in a child. International journal of cardiology 20090724
Meropenem-clavulanate: a new strategy for the treatment of tuberculosis? ChemMedChem 20090701
The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276. Biochemistry 20090602
Phenotypic and molecular characterization of a novel beta-lactamase carried by Klebsiella pneumoniae, CTX-M-72, derived from CTX-M-3. The Journal of general and applied microbiology 20090601
Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. Journal of medical microbiology 20090501
The influence of potassium clavulanate on the rate of amoxicillin sodium degradation in phosphate and acetate buffers in the liquid state. Drug development and industrial pharmacy 20090401
Rhinosinusitis in children and asthma severity. Current opinion in allergy and clinical immunology 20090401
[Use of antibiotics in emergency units: qualitative and quantitative assessment]. Medecine et maladies infectieuses 20090301
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science (New York, N.Y.) 20090227
Computational modeling study on formation of acyclic clavulanate intermediates in inhibition of class A beta-lactamase: water-assisted proton transfer. The journal of physical chemistry. A 20090226
Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidence. Journal of the American Chemical Society 20090218
A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production. Journal of industrial microbiology & biotechnology 20090201
A bullous lesion in a neutropenic adolescent. Pediatric emergency care 20090201
Pylephlebitis after a duodenal ulcer in a patient with metastasised colon carcinoma treated with chemotherapy and bevacizumab: a case report. The Netherlands journal of medicine 20090201
Dissection of the stepwise mechanism to beta-lactam formation and elucidation of a rate-determining conformational change in beta-lactam synthetase. The Journal of biological chemistry 20090102
[Salmonella enteritidis infection presenting with septic shock, renal failure and cutaneous manifestations]. Klinische Padiatrie 20090101
Redefining extended-spectrum beta-lactamases: balancing science and clinical need. The Journal of antimicrobial chemotherapy 20090101
Spondylodiscitis due to Peptostreptococcus spp: a case report. Joint, bone, spine : revue du rhumatisme 20090101
An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus. Bioscience, biotechnology, and biochemistry 20090101
Cephalosporins with clavulinic acid. Indian pediatrics 20090101
Selective immunoglobulin M deficiency presenting with recurrent impetigo: a case report and review of the literature. International archives of allergy and immunology 20090101
Amoxicillin and amoxicillin plus clavulanate: a safety review. Expert opinion on drug safety 20090101
In vitro synergistic antibacterial activities of helvolic acid on multi-drug resistant Staphylococcus aureus. Natural product research 20090101
In vitro evaluation of a new cefixime-clavulanic acid combination for gram-negative bacteria. The Southeast Asian journal of tropical medicine and public health 20090101
[An HIV-positive homosexual man with fever and a skin lesion]. Enfermedades infecciosas y microbiologia clinica 20090101
Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus. Metabolic engineering 20090101
Development of a new HPLC method for the simultaneous determination of ticarcillin and clavulanic acid in pharmaceutical formulations. Journal of AOAC International 20090101
Bilateral anterior cerebral artery infarction following viper bite. The Journal of the Association of Physicians of India 20090101
[Efficient combination of clavulanate and beta-lactam antibiotics against extensively drug-resistant M. tuberculosis]. Medecine sciences : M/S 20090101
An unusual giant subacute necrotizing sialadenitis as an emergency case of otolaryngology. Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat 20090101
[Antibiotic prophylaxis in breast surgery. Preliminary resuls of a multicenter randomized study on 1400 cases]. Annali italiani di chirurgia 20090101
Simultaneous spectrophotometric determination of Cefpodoxime proxetil and Potassium clavulanate. Hindustan antibiotics bulletin 20090101
Induction potential of clavulanic acid toward L1 and L2 beta-lactamases of Stenotrophomonas maltophilia. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20081201
A case of allergic contact dermatitis to clavulanic acid. Contact dermatitis 20081201
A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source. Journal of applied microbiology 20081201
[Two cases of Bacillus infection and immunodepression]. Medecine et maladies infectieuses 20081101
Nasal packing after septoplasty: a randomized comparison of packing versus no packing in 88 patients. Ear, nose, & throat journal 20081101
A two-component regulatory system involved in clavulanic acid production. The Journal of antibiotics 20081101
Once or twice daily versus three times daily amoxicillin with or without clavulanate for the treatment of acute otitis media. The Cochrane database of systematic reviews 20081008
Eikenella corrodens as a causative agent for neonatal conjunctivitis. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20081001
EUS-FNA of enlarged necrotic lymph nodes may cause infectious mediastinitis. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20081001
[Case of pneumonia caused by beta-lactamase-producing and amoxicillin/clavulanate resistant strains of H. influenzae]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080901
Clavulanic acid decomposition is catalyzed by the compound itself and by its decomposition products. Journal of pharmaceutical sciences 20080801
A convenient microbiological assay employing cell-free extracts for the rapid characterization of Gram-negative carbapenemase producers. The Journal of antimicrobial chemotherapy 20080801
Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury. Hepatology (Baltimore, Md.) 20080801
In vitro study to compare sensitivity of amoxicillin+clavulanic acid and cefpodoxime+clavulanic acid among beta-lactamase positive clinical isolates of gram-positive and gram-negative pathogens. Journal of the Indian Medical Association 20080801
Surgical prophylaxis in liver transplantation: is it necessary but not enough? Transplantation 20080627
Surgical site infection in liver transplant recipients: impact of the type of perioperative prophylaxis. Transplantation 20080627
High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus. Biotechnology and bioengineering 20080615
Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate. Biochemistry 20080513
Immobilization of Streptomyces clavuligerus on loofah sponge for the production of clavulanic acid. Bioresource technology 20080501
[Antimicrobial susceptibility of 80 Moraxella catarrhalis strains isolated in the children's hospital of Tunis]. Pathologie-biologie 20080501
A retrospective review of ampicillin-sulbactam and amoxicillin + clavulanate vs cefazolin/cephalexin and erythromycin in the setting of preterm premature rupture of membranes: maternal and neonatal outcomes. American journal of obstetrics and gynecology 20080501
Structure-function studies of arginine at position 276 in CTX-M beta-lactamases. The Journal of antimicrobial chemotherapy 20080401
The first major extended-spectrum beta-lactamase outbreak in Scandinavia was caused by clonal spread of a multiresistant Klebsiella pneumoniae producing CTX-M-15. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20080401
Severe haemoptysis associated with seizures in a dog. New Zealand veterinary journal 20080401
Pre- and post-exposure prophylaxis of experimental Burkholderia pseudomallei infection with doxycycline, amoxicillin/clavulanic acid and co-trimoxazole. The Journal of antimicrobial chemotherapy 20080301
Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp. Microbiology (Reading, England) 20080301
Functional effects of increased copy number of the gene encoding proclavaminate amidino hydrolase on clavulanic acid production in Streptomyces clavuligerus ATCC 27064. Journal of microbiology and biotechnology 20080301
False extended-spectrum beta-lactamase detection in Acinetobacter spp. due to intrinsic susceptibility to clavulanic acid. The Journal of antimicrobial chemotherapy 20080201
What is your diagnosis? Epidural empyema. The Journal of small animal practice 20080201
Tissue depletion of amoxicillin and its major metabolites in pigs: influence of the administration route and the simultaneous dosage of clavulanic acid. Journal of agricultural and food chemistry 20080123
Detection of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in effluents and sludge of a hospital sewage treatment plant. Letters in applied microbiology 20080101
Hyperproduction of inhibitor-susceptible TEM beta-lactamase is responsible for resistance of Serratia marcescens to beta-lactam-beta-lactamase inhibitor combinations. Chemotherapy 20080101
Phenotypic detection of extended-spectrum beta-lactamase production in Enterobacteriaceae: review and bench guide. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080101
Orthodox and unorthodox clavulanate combinations against extended-spectrum beta-lactamase producers. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080101
Applying near-infrared spectroscopy in downstream processing: one calibration for multiple clarification processes of fermentation media. Biotechnology progress 20080101
Clavulanic acid: a review. Biotechnology advances 20080101
Simultaneous determination of potassium clavulanate and cefixime in synthetic mixtures by high-performance liquid chromatography. Journal of AOAC International 20080101
[Comparative study on the efficacy of cefuroxime, amoxycillin/clavulanic acid and fosfomycin in prophylaxis of nosocomial infections in oncologic patients after surgical operations]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20080101
Beta-lactam effects on mixed cultures of common respiratory isolates as an approach to treatment effects on nasopharyngeal bacterial population dynamics. PloS one 20080101
Hypersensitivity to clavulanic acid in children. Allergologia et immunopathologia 20080101
Randomized, multicentre, comparative clinical evaluation of cefuroxime-sulbactam versus amoxicillin-clavulanic acid therapy in the treatment of lower respiratory tract infections. The Journal of international medical research 20080101
Diagnosis of clavulanic acid allergy using basophil activation and leukotriene release by basophils. Journal of investigational allergology & clinical immunology 20080101
[Sepsis--a new life-threat or better defined old disease entity]. Medycyna doswiadczalna i mikrobiologia 20080101
[Antimicrobial resistance profile of E. coli and Klebsiella spp. from urine in the Infectious Diseases Hospital Iaşi]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20080101
Evaluation of restoration of sensitivities of resistant Staphylococcus aureus isolates by using cefuroxime and clavulanic acid in combination. Journal of Ayub Medical College, Abbottabad : JAMC 20080101
Observation of an acryloyl-thiamin diphosphate adduct in the first step of clavulanic acid biosynthesis. Journal of the American Chemical Society 20071226
The efficacy and safety of cefovecin in the treatment of feline abscesses and infected wounds. The Journal of small animal practice 20071201
Disposition and oral bioavailability of amoxicillin and clavulanic acid in pigs. Journal of veterinary pharmacology and therapeutics 20071201
Levofloxacin vs. azithromycin pharmacodynamic activity against S. pneumoniae and H. influenzae with decreased susceptibility to amoxicillin/clavulanic acid. Journal of chemotherapy (Florence, Italy) 20071201
Simultaneous determination of amoxicillin and clavulanic acid in human plasma by isocratic reversed-phase HPLC using UV detection. Journal of pharmaceutical and biomedical analysis 20071105
Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate. Biochemistry 20071030
Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244. Biochemistry 20071009
Mid-trimester amniocentesis and antibiotic prophylaxis. Prenatal diagnosis 20071001
Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production. Molecular microbiology 20071001
[Prevalence of extended-spectrum beta-lactamases in nosocomial Escherichia coli and Klebsiella spp. strains isolated from blood cultures]. Mikrobiyoloji bulteni 20071001
Kinetics of amoxicillin and clavulanate degradation alone and in combination in aqueous solution under frozen conditions. International journal of pharmaceutics 20070905
Rapid detection of extended-spectrum beta-lactamase-producing Gram-negative bacilli in blood cultures. The Journal of antimicrobial chemotherapy 20070901
Amoxicillin-clavulanic acid and trimethoprim- sulfamethoxazole in rodent feed and water: effects of compounding on antibiotic stability. Journal of the American Association for Laboratory Animal Science : JAALAS 20070901
Sulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamase. Biochemistry 20070807
Quantitative analysis of clavulanic acid in porcine tissues by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Analytica chimica acta 20070806
In vitro activity of ceftaroline (PPI-0903M, T-91825) against bacteria with defined resistance mechanisms and phenotypes. The Journal of antimicrobial chemotherapy 20070801
Raman crystallographic studies of the intermediates formed by Ser130Gly SHV, a beta-lactamase that confers resistance to clinical inhibitors. Biochemistry 20070724
Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus. Bioresource technology 20070701
Clinical efficacy and safety of cefovecin in the treatment of canine pyoderma and wound infections. The Journal of small animal practice 20070701
Sensitivity pattern of gram negative bacilli to three beta-lactam/beta-lactamase inhibitor combinations using the automated API system. Indian journal of medical microbiology 20070701
Macrolides, quinolones and amoxicillin/clavulanate for chronic bronchitis: a meta-analysis. The European respiratory journal 20070601
Infected epithelial inclusion cyst mimicking subconjunctival abscess after strabismus surgery. Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20070601
Pradofloxacin in the treatment of canine deep pyoderma: a multicentred, blinded, randomized parallel trial. Veterinary dermatology 20070601
Acute conjunctivitis caused by Actinobacillus ureae. Pediatrics international : official journal of the Japan Pediatric Society 20070601
Escherichia coli and amoxicillin/clavulanate resistance at the University Hospital of the West Indies 1994 versus 2003. The West Indian medical journal 20070601
Impact of amoxicillin, associated or not with clavulanic acid, on pharyngeal colonization and selection of Streptococcus pneumoniae resistance in children under 5 years of age. European journal of pediatrics 20070501
Sensitivity and specificity of various beta-lactam antibiotics and phenotypical methods for detection of TEM, SHV and CTX-M extended-spectrum beta-lactamases. Journal of chemotherapy (Florence, Italy) 20070401
Mechanism for cyclization reaction by clavaminic acid synthase. Insights from modeling studies. Biochemistry 20070327
Structure and Raman spectrum of clavulanic acid in aqueous solution. The journal of physical chemistry. B 20070315
Simultaneous determination of glycerol and clavulanic acid in an antibiotic bioprocess using attenuated total reflectance mid infrared spectroscopy. Analytica chimica acta 20070307
[Pelvic and abdominal actinomycosis presenting as a parietal mass]. Presse medicale (Paris, France : 1983) 20070301
A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142. Applied biochemistry and biotechnology 20070301
Clavulanic acid dehydrogenase: structural and biochemical analysis of the final step in the biosynthesis of the beta-lactamase inhibitor clavulanic acid. Biochemistry 20070213
The role of antibiotic prophylaxis in elective tension-free mesh inguinal hernia repair: results of a single-centre prospective randomised trial. International journal of clinical practice 20070201
The magnitude and time course of changes in mycophenolic acid 12-hour predose levels during antibiotic therapy in mycophenolate mofetil-based renal transplantation. Therapeutic drug monitoring 20070201
5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus. Chemistry & biology 20070201
Delayed ulnar neuropathy and infection due to a radiolucent foreign body in the hypothenar eminence. Orthopedics 20070201
Outcomes in children treated for persistent bacterial bronchitis. Thorax 20070101
Susceptibilities of ESBL-producing Enterobacteriaceae to ertapenem, meropenem and piperacillin-tazobactam with and without clavulanic acid. Chemotherapy 20070101
Outpatient intravenous antibiotics for methicillin-resistant Staphylococcus aureus sinusitis. American journal of rhinology 20070101
[Susceptibility and molecular mechanisms of resistance to cephalosporins of Escherichia coli strains isolated from patients with nosocomial infections]. Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20070101
Effectiveness of early switch from intravenous to oral antibiotics in severe community acquired pneumonia: multicentre randomised trial. BMJ (Clinical research ed.) 20061209
Occurrence of a novel SHV-type enzyme (SHV-55) among isolates of Klebsiella pneumoniae from Portuguese origin in a comparison study for extended-spectrum beta-lactamase-producing evaluation. Diagnostic microbiology and infectious disease 20061201
Pharmacokinetic and pharmacodynamic assessment of co-amoxiclav in the treatment of melioidosis. The Journal of antimicrobial chemotherapy 20061201
Pustular vasculitis disclosing a systemic lupus erythematosus. International journal of dermatology 20061201
Occurrence of extended-spectrum beta-lactamases in Enterobacteriaceae isolated from hospitalized patients in Curitiba, southern Brazil. The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20061201
A cylinder-plate method for microbiological assay of clavulanic acid. Pharmeuropa scientific notes 20061201
Determination of clavulanic acid in calf plasma by liquid chromatography tandem mass spectrometry. Journal of mass spectrometry : JMS 20061101
Effect of antibiotic treatment of subclinical mastitis on human immunodeficiency virus type 1 RNA in human milk. Journal of tropical pediatrics 20061001
Epidemiology of adverse cutaneous drug reactions. A prospective study in hospitalized patients. Archives of medical research 20061001
Extreme thrombocytosis under the treatment by amoxicillin/clavulanate. Pharmacy world & science : PWS 20061001
Influence of feeding conditions on clavulanic acid production in fed-batch cultivation with medium containing glycerol. Applied microbiology and biotechnology 20060901
Topical ciprofloxacin/dexamethasone superior to oral amoxicillin/clavulanic acid in acute otitis media with otorrhea through tympanostomy tubes. Pediatrics 20060901
A naturalistic comparison of amoxicillin/clavulanate extended release versus immediate release in the treatment of acute bacterial sinusitis in adults: A retrospective data analysis. Clinical therapeutics 20060901
An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus. Molecular microbiology 20060801
Enhancement of antimicrobial activities of cefteram or clavulanic acid/amoxicillin against cefixime-resistant Neisseria gonorrhoeae in the presence of clarithromycin or azithromycin. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20060801
Pharmacokinetically enhanced amoxicillin/clavulanate (2,000/125 mg) in acute bacterial rhinosinusitis caused by Streptococcus pneumoniae, including penicillin-resistant strains. Ear, nose, & throat journal 20060801
In vitro pyrogenicity of Gram-positive bacteria--validation of the kit using fresh human whole blood. Pharmeuropa scientific notes 20060801
Activity of mecillinam against AmpC beta-lactamase-producing Escherichia coli. The Journal of antimicrobial chemotherapy 20060701
Characterisation and molecular epidemiology of extended-spectrum beta-lactamase-producing Enterobacter cloacae isolated from a district teaching hospital in Taiwan. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20060601
SPIR MRI usefulness for steroid treatment management in Tolosa-Hunt syndrome. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20060601
Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus. Metabolic engineering 20060501
[Pseudomembranous diphtheria caused by Corynebacterium ulcerans]. La Revue de medecine interne 20060401
Characterization of pbpA and pbp2 encoding penicillin-binding proteins located on the downstream of clavulanic acid gene cluster in Streptomyces clavuligerus. Biotechnology letters 20060301
Activity of mecillinam against ESBL producers in vitro. The Journal of antimicrobial chemotherapy 20060201
[Bilateral breast bacterial cellulite secondary to Streptococcus agalactiae septicemia]. Annales de dermatologie et de venereologie 20060201
[Impetigo]. Annales de dermatologie et de venereologie 20060201
ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid. The Journal of biological chemistry 20060106
Sequential injection analysis for the simultaneous determination of clavulanic acid and amoxicillin in pharmaceuticals using second-order calibration. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060101
Oral clindamycin 300 mg BID compared with oral amoxicillin/clavulanic acid 1 g BID in the outpatient treatment of acute recurrent pharyngotonsillitis caused by group a beta-hemolytic streptococci: an international, multicenter, randomized, investigator-blinded, prospective trial in patients between the ages of 12 and 60 years. Clinical therapeutics 20060101
Laboratory diagnosis of bloodstream infections caused by extended-spectrum beta-lactamase-producing E. coli and Klebsiella species. British journal of biomedical science 20060101
Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus. Research in microbiology 20060101
[High effectiveness of the method with cefpirome in detection of extended-spectrum beta-lactamases in different species of gram-negative bacilli]. Medycyna doswiadczalna i mikrobiologia 20060101
Modified double-disc test for detection of extended-spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae. British journal of biomedical science 20060101
Differential effects of beta-lactams on human IFN-gamma activity. The Journal of antimicrobial chemotherapy 20051201
Beta-lactamase inhibition with clavulanic acid supplementing standard amoxycillin-based triple therapy does not increase Helicobacter pylori eradication rate. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20051101
Using redox potential to detect microbial activities during clavulanic acid biosynthesis in Streptomyces clavuligerus. Biotechnology letters 20051101
Clavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition. The Journal of biological chemistry 20051021
High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase. The Journal of biological chemistry 20051014
Antibiotics for childhood community-acquired pneumonia in a region with a high prevalence of penicillin non-susceptible Streptococcus pneumoniae. The Journal of antimicrobial chemotherapy 20050901
AmpC beta-lactamase producing bacterial isolates from Kolkata hospital. The Indian journal of medical research 20050901
Monitoring complex media fermentations with near-infrared spectroscopy: comparison of different variable selection methods. Biotechnology and bioengineering 20050820
The safety of amoxicillin/clavulanic acid and cefuroxime during lactation. Therapeutic drug monitoring 20050801
Crescentic glomerulonephritis associated with bacterial endocarditis--antibiotics alone may be sufficient. A case report. JPMA. The Journal of the Pakistan Medical Association 20050801
Medical treatment for rhinosinusitis associated with adenoidal hypertrophy in children: an evaluation of clinical response and changes on magnetic resonance imaging. The Annals of otology, rhinology, and laryngology 20050801
[Effect of lat disruption on clavulanic acid production]. Wei sheng wu xue bao = Acta microbiologica Sinica 20050801
Urinary concentrations and bactericidal activity against amoxicillin-nonsusceptible strains of Escherichia coli with single-dose, oral, sustained-release amoxicillin/clavulanic acid: a phase I, open-label, noncomparative clinical trial in healthy volunteers. Clinical therapeutics 20050701
[Comparison of different phenotypic methods detecting extended spectrum beta-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii strains]. Mikrobiyoloji bulteni 20050701
[Comparative study of 2 antibiotic combinations in the treatment of rapidly progressing periodontitis]. Odonto-stomatologie tropicale = Tropical dental journal 20050601
Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus. Molecular microbiology 20050501
Subclinical mastitis and antimicrobial susceptibility of Staphylococcus caprae and Staphylococcus epidermidis isolated from two Italian goat herds. Journal of dairy science 20050501
Antibacterial susceptibility of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae and Escherichia coli. The Israel Medical Association journal : IMAJ 20050501
Influence of dissolved oxygen and shear conditions on clavulanic acid production by Streptomyces clavuligerus. Bioprocess and biosystems engineering 20050401
X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster. The Biochemical journal 20050115
Ionic liquids as advantageous solvents for headspace gas chromatography of compounds with low vapor pressure. Analytical chemistry 20050115
Rapid detection of extended-spectrum beta-lactamase (ESBL)-producing organisms in blood culture. The Journal of antimicrobial chemotherapy 20050101
Pseudo T-cell lymphoma with clonal expansion related to hypersensitivity to amoxicillin. Haematologica 20050101
Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952. Research in microbiology 20050101
[A blinded comparison of palatability of 13 common pediatric antibiotic suspensions]. Wiadomosci lekarskie (Warsaw, Poland : 1960) 20050101
Prevalence of extended-spectrum beta-lactamases in Enterobacteriaceae, Pseudomonas and Stenotrophomonas as determined by the VITEK 2 and E test systems in a Kuwait teaching hospital. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101
Comparison of antimicrobial resistance of Acinetobacter baumannii clinical isolates from Shanghai and Hong Kong. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20050101
Information content in organic molecules: aggregation states and solvent effects. Journal of chemical information and modeling 20050101
New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review. Clinical pharmacokinetics 20050101
Delayed selective reaction to clavulanic acid: a case report. Journal of investigational allergology & clinical immunology 20050101
Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
Pharmacodynamic studies of amoxicillin against Streptococcus pneumoniae: comparison of a new pharmacokinetically enhanced formulation (2000 mg twice daily) with standard dosage regimens. The Journal of antimicrobial chemotherapy 20041201
Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus. Microbiology (Reading, England) 20041201
[Prophylactic antibiotic therapy (amoxicillin + clavulanic acid) before embryo transfer for IVF is useless. Results of a randomized study]. Journal de gynecologie, obstetrique et biologie de la reproduction 20041201
A cell-based beta-lactamase reporter gene assay for the identification of inhibitors of hepatitis C virus replication. Analytical biochemistry 20041115
Combined chemical and biological oxidation of penicillin formulation effluent. Journal of environmental management 20041101
Evaluation of the MicroScan ESBL plus confirmation panel for detection of extended-spectrum beta-lactamases in clinical isolates of oxyimino-cephalosporin-resistant Gram-negative bacteria. The Journal of antimicrobial chemotherapy 20041101
Detection of integrons and antibiotic-resistance genes in Salmonella enterica serovar Typhimurium isolates with resistance to ampicillin and variable susceptibility to amoxicillin-clavulanate. International journal of antimicrobial agents 20041001
Economic evaluation of the antibiotic treatment of exacerbations of chronic bronchitis and COPD in primary care. International journal of clinical practice 20041001
Outcomes of treatment pathways in outpatient treatment of low risk febrile neutropenic cancer patients. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20040901
Prognostic significance of wound infections following major head and neck cancer surgery: an open non-comparative prospective study. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20040901
Phenotypic detection of extended-spectrum and AmpC beta-lactamases by a new spot-inoculation method and modified three-dimensional extract test: comparison with the conventional three-dimensional extract test. The Journal of antimicrobial chemotherapy 20040901
First-trimester exposure to amoxycillin/clavulanic acid: a prospective, controlled study. British journal of clinical pharmacology 20040901
Pulmonary complications following major head and neck surgery with tracheostomy: a prospective, randomized, controlled trial of prophylactic antibiotics. Archives of otolaryngology--head & neck surgery 20040901
[Surveillance of antimicrobial susceptibility of Haemophilus influenzae isolates from children in Beijing, Shanghai, and Guangzhou 2000 - 2002]. Zhonghua yi xue za zhi 20040817
Aza-boronic acids as non-beta-lactam inhibitors of AmpC-beta-lactamase. Bioorganic & medicinal chemistry letters 20040802
In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor. The Journal of antimicrobial chemotherapy 20040801
A Bacteroides thetaiotamicron porin that could take part in resistance to beta-lactams. International journal of antimicrobial agents 20040801
Gemifloxacin once daily for 7 days compared to amoxicillin/clavulanic acid thrice daily for 10 days for the treatment of community-acquired pneumonia of suspected pneumococcal origin. Respiratory medicine 20040801
Evaluation of a new cefepime-clavulanate ESBL Etest to detect extended-spectrum beta-lactamases in an Enterobacteriaceae strain collection. The Journal of antimicrobial chemotherapy 20040701
Typing and characterization of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex in a Chinese hospital. Journal of medical microbiology 20040701
Acute otitis media in children: current epidemiology, microbiology, clinical manifestations, and treatment. Chang Gung medical journal 20040701
[Naso-sinusoidal infections in children and adults. Part I: Children]. La Revue du praticien 20040630
[Treatment mostly not in line with current knowledge. New guidelines for sinusitis therapy]. MMW Fortschritte der Medizin 20040610
Canine tonsillitis associated with Listeria monocytogenes. The Veterinary record 20040605
Antibiotic susceptibility of coagulase-negative staphylococci isolated from goats' milk. International journal of antimicrobial agents 20040601
[Amoxicillin in tonsillectomy: preliminary data on the evaluation of serum and tissue concentrations]. Recenti progressi in medicina 20040601
Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus. Microbiology (Reading, England) 20040501
Comparison of the double-disk, combined disk, and Etest methods for detecting metallo-beta-lactamases in gram-negative bacilli. Diagnostic microbiology and infectious disease 20040501
Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC. Journal of pharmaceutical and biomedical analysis 20040401
[Bacterial resistance and pharmacodynamics as the basis for prescribing antibiotics in respiratory infections]. Enfermedades infecciosas y microbiologia clinica 20040401
The vitro efficacy of beta-lactam and beta-lactamase inhibitors against multidrug resistant clinical strains of Mycobacterium tuberculosis. International journal of antimicrobial agents 20040401
False-positive extended-spectrum beta-lactamase tests for Klebsiella oxytoca strains hyperproducing K1 beta-lactamase. The Journal of antimicrobial chemotherapy 20040301
[E. coli: resistance to quinolones and beta-lactams of clinical strains isolated in the Franche-Comté region of France]. Pathologie-biologie 20040301
Cefotaximases (CTX-M-ases), an expanding family of extended-spectrum beta-lactamases. Canadian journal of microbiology 20040301
[Profile of antimicrobial resistance of agents causing urinary tract infections in children]. La Tunisie medicale 20040301
Crystal structure and mechanistic implications of N2-(2-carboxyethyl)arginine synthase, the first enzyme in the clavulanic acid biosynthesis pathway. The Journal of biological chemistry 20040213
[Actinomycosis]. Praxis 20040204
Pharmacodynamic study of beta-lactams alone and in combination with beta-lactamase inhibitors against Pseudomonas aeruginosa possessing an inducible beta-lactamase. The Journal of antimicrobial chemotherapy 20040201
Evaluation of penicillin-based inhibitors of the class A and B beta-lactamases from Bacillus anthracis. Biochemical and biophysical research communications 20040116
[Surveillance on antibiotic resistance of Stenotrophomonas maltophilia in Chengdu and Chongqing area]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20040101
Zebra bite to a South African tourist. Journal of travel medicine 20040101
Prulifloxacin. Drugs 20040101
[Respiratory fluoroquinolones in the treatment of exacerbations of chronic obstructive lung disease]. Problemy tuberkuleza i boleznei legkikh 20040101
Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130. The Journal of biological chemistry 20031226
Three simultaneous dissolution profiles on a solid pharmaceutical formulation by a FIA manifold provided with a single spectrophotometric detector. Journal of pharmaceutical and biomedical analysis 20031204
Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. Pediatric research 20031201
Following the reactions of mechanism-based inhibitors with beta-lactamase by Raman crystallography. Biochemistry 20031125
Persistent otorrhoea after ventilation tube insertion: a treatment protocol. International journal of clinical practice 20031101
Evaluation of Oxoid combination discs for detection of extended-spectrum beta-lactamases. The Journal of antimicrobial chemotherapy 20031001
Urinary tract infections in South Croatia: aetiology and antimicrobial resistance. International journal of antimicrobial agents 20031001
Acute otitis media in children: amoxicillin remains the standard antibiotic, but justified in certain situations only. Prescrire international 20031001
Simultaneous determination of ticarcillin and clavulanate in rabbit serum and tissue cage fluid by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030905
A review of the antimicrobial activity of clavulanate. The Journal of antimicrobial chemotherapy 20030701
What is your diagnosis? Osteomyelitis of the fourth sternebra. The Journal of small animal practice 20030701
[Phenotypes of beta-lactam resistance in the genus Aeromonas]. Pathologie-biologie 20030701
Simple and reliable multiplex PCR assay for detection of blaTEM, bla(SHV) and blaOXA-1 genes in Enterobacteriaceae. FEMS microbiology letters 20030627
Industrial production of beta-lactam antibiotics. Applied microbiology and biotechnology 20030601
Variable absorption of clavulanic acid after an oral dose of 25 mg/kg of Clavubactin and Synulox in healthy dogs. Journal of veterinary pharmacology and therapeutics 20030601
Cefepime versus ticarcillin and clavulanate potassium and aztreonam for febrile neutropenia therapy in high-dose chemotherapy patients. American journal of clinical oncology 20030601
[Evaluation of antibacterial activity of amoxycillin sodium and clavulanate potassium and the pharmacoeconomics in the therapy of acute respiratory infection]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20030501
Application of MEKC for determination of ticarcillin and clavulanic acid in Timentin intravenous preparation. Journal of pharmaceutical and biomedical analysis 20030424
[Meningitis caused by multiresistant E. coli after an echo-directed transrectal biopsy]. Actas urologicas espanolas 20030401
Severe hepatitis associated with oxacillin therapy. Southern medical journal 20030301
[beta-Lactamase-inhibitor combinations]. Nihon rinsho. Japanese journal of clinical medicine 20030301
[Pilot study of coadjuvant treatment of recurrent cystitis in women by means of AM3 (Immnoferon)]. Actas urologicas espanolas 20030301
[Resistance of respiratory tract infection agents is still increasing. Is its time for new antibiotic strategies?]. MMW Fortschritte der Medizin 20030227
Identical pattern of highly variable absorption of clavulanic acid from four different oral formulations of co-amoxiclav in healthy subjects. The Journal of antimicrobial chemotherapy 20030201
Continuous clavulanic acid adsorption process. Applied biochemistry and biotechnology 20030101
Selective immediate hypersensitivity to clavulanic acid. The Annals of pharmacotherapy 20030101
Inflammatory polyp in the middle ear with secondary suppurative meningoencephalitis in a cat. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association 20030101
Efficiency of procedures for induction and cultivation of Pseudomonas syringae pv. pisi L-form. Microbiological research 20030101
Unexpected advanced generation cephalosporinase activity of the M69F variant of SHV beta-lactamase. The Journal of biological chemistry 20021206
Identification of bacteria in acute endodontic infections and their antimicrobial susceptibility. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20021201
[Levofloxacin versus beta-lactamic therapy in community acquired pneumonia that requires hospitalization]. Anales de medicina interna (Madrid, Spain : 1984) 20021201
A sequential injection analysis system for potassium clavulanate determination using two potentiometric detectors. Journal of pharmaceutical and biomedical analysis 20021107
Design, synthesis, and biological evaluation of a series of beta-lactam-based prodrugs. Bioorganic & medicinal chemistry 20021101
Complete cervical tracheal rupture in children after closed trauma. Journal of pediatric surgery 20021101
Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC with UV detection. Journal of pharmaceutical and biomedical analysis 20021015
Factors governing intrinsic chemical reactivity differences between clavulanic and penicillanic acids. Journal of the American Chemical Society 20021009
Simultaneous drug allergies. Allergy 20021001
Pharmacodynamics of amoxicillin/clavulanic acid against Haemophilus influenzae in an in vitro kinetic model: a comparison of different dosage regimens including a pharmacokinetically enhanced formulation. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021001
Clinical microbiological case: a firm, right infraclavicular mass in an adult woman with connective tissue disease. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021001
New reactions in clavulanic acid biosynthesis. Current opinion in chemical biology 20021001
Rationale for use of antibiotics in periodontics. Journal of periodontology 20021001
Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis. The Biochemical journal 20020901
Amoxicillin/clavulanic acid versus cefotaxime for antimicrobial prophylaxis in abdominal surgery: a randomized trial. Journal of chemotherapy (Florence, Italy) 20020801
Removal of the fermentation by-product succinyl L-tyrosine from the beta-lactamase inhibitor clavulanic acid using a molecularly imprinted polymer. Biotechnology and bioengineering 20020705
Sensitization to clavulanic acid in Augmentin. Contact dermatitis 20020701
CE versus LC for simultaneous determination of amoxicillin/clavulanic acid and ampicillin/sulbactam in pharmaceutical formulations for injections. Journal of pharmaceutical and biomedical analysis 20020620
[Otitis media and antibiotics 1]. Ugeskrift for laeger 20020603
[Otitis media and antibiotics 2]. Ugeskrift for laeger 20020603
Non-radioactive PCR-SSCP with a single PCR step for detection of inhibitor resistant beta-lactamases in Escherichia coli. Journal of microbiological methods 20020601
Emerging carbapenemases in Gram-negative aerobes. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20020601
[Focal bacterial nephritis: diagnosis and treatment]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20020601
Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors. FEMS microbiology letters 20020521
Effects of large dosages of amoxicillin/clavulanate or azithromycin on nasopharyngeal carriage of Streptococcus pneumoniae, Haemophilus influenzae, nonpneumococcal alpha-hemolytic streptococci, and Staphylococcus aureus in children with acute otitis media. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020515
The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene. Microbiology (Reading, England) 20020501
ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity. European journal of biochemistry 20020401
5-Dethia-5-oxacephams: toward correlation of absolute configuration and chiroptical properties. The Journal of organic chemistry 20020308
The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant. Microbiology (Reading, England) 20020301
Increase of in vitro amoxycillin bactericidal activity by clavulanic acid against Neisseria meningitis using time-kill curves. International journal of antimicrobial agents 20020301
[Patient with a lung abscess, primarily treated with drainage followed by antibiotics]. Nederlands tijdschrift voor geneeskunde 20020112
Severe cellulitis/myositis caused by Stenotrophomonas maltophilia. The Annals of pharmacotherapy 20020101
Improvement for the production of clavulanic acid by mutant Streptomyces clavuligerus. Letters in applied microbiology 20020101
Clavulanic acid degradation in Streptomyces clavuligerus fed-batch cultivations. Biotechnology progress 20020101
[Paraglottic laryngeal abscesses]. Acta otorrinolaringologica espanola 20020101
Variable absorption of clavulanic acid after an oral dose of 25 mg/kg of Clavubactin and Synulox in healthy cats. TheScientificWorldJournal 20020101
Results of a pilot trial comparing prolonged intravenous antibiotics with sequential intravenous/oral antibiotics for children with perforated appendicitis. Archives of surgery (Chicago, Ill. : 1960) 20011201
[Caustic lesions of the esophagus in adults]. Annales de chirurgie 20011201
[A case of temporal arteritis presenting with sensorineural hearing loss]. Recenti progressi in medicina 20011201
Evidence for a true post-beta-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20011201
[Activity of different antimicrobial agents against penicillin-resistant Streptococcus pneumoniae]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20011201
Real time monitoring biomass concentration in Streptomyces clavuligerus cultivations with industrial media using a capacitance probe. Journal of biotechnology 20011117
Varicella complicated by group A streptococcal facial cellulitis. Journal of the American Academy of Dermatology 20011101
[Objectives for antibiotic therapy in acute exacerbations of chronic bronchitis]. Presse medicale (Paris, France : 1983) 20011027
[Ulcus vulvae acutum. Report of 5 cases]. Minerva pediatrica 20011001
Clavulanate-selective electrodes--application to pharmaceutical formulations. Fresenius' journal of analytical chemistry 20011001
Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nature structural biology 20010801
Neutrophilic fixed drug eruption. The Australasian journal of dermatology 20010801
Bacteroides fragilis arthritis in a patient with sickle cell disease. The American journal of medicine 20010801
Controlled study of the efficacy of clavulanic acid-potentiated amoxycillin in the treatment of Chlamydia psittaci in cats. The Veterinary record 20010721
Penicillins and beta-lactamase inhibitor combinations. Journal of the American Veterinary Medical Association 20010615
Simultaneous determination of amoxycillin and clavulanic acid in pharmaceutical dosage forms by LC with amperometric detection. Journal of pharmaceutical and biomedical analysis 20010501
[Fundamental and clinical studies on beta-lactamase inhibitors]. Nihon rinsho. Japanese journal of clinical medicine 20010401
The clinical pharmacokinetics of a new pharmacokinetically enhanced formulation of amoxicillin/clavulanate. Clinical therapeutics 20010401
Effects of preculture variability on clavulanic acid fermentation. Biotechnology and bioengineering 20010320
Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus. Microbiology (Reading, England) 20010201
Properties of multidrug-resistant, ESBL-producing Proteus mirabilis isolates and possible role of beta-lactam/beta-lactamase inhibitor combinations. International journal of antimicrobial agents 20010201
Comparison of five different methods for detection of SHV extended-spectrum beta-lactamases. Journal of chemotherapy (Florence, Italy) 20010201
Sensitivity of Borrelia burgdorferi strains isolated in the Czech Republic. Central European journal of public health 20010201
Bioequivalence study of a novel Solutab tablet formulation of amoxicillin/clavulanic acid versus the originator film-coated tablet. International journal of clinical pharmacology and therapeutics 20010201
[Lemierre's syndrome: a case report]. Revue de pneumologie clinique 20010201
[Multiresistant tuberculosis caused by Mycobacterium bovis and human immunodeficiency virus infection. Are there new therapeutic possibilities?]. Enfermedades infecciosas y microbiologia clinica 20010101
[Septic arthritis of the elbow due to Actinomyces spp. and a foreign body]. Enfermedades infecciosas y microbiologia clinica 20010101
Activity of cefepime, cefotaxime, ceftazidime, and aztreonam against extended-spectrum-producing isolates of Klebsiella pneumoniae and Escherichia coli from Chilean hospitals. Diagnostic microbiology and infectious disease 20010101
Determination of beta-lactamase activities and antibiotic susceptibility of some Bacillus strains causing food poisoning. Drug metabolism and drug interactions 20010101
[Antibiotic prophylaxis of postoperative complications in surgical treatment of pulmonary, tracheal and mediastinal tumors]. Anesteziologiia i reanimatologiia 20010101
[Occurrence of beta-lactamase type ESBL and IBL in Pseudomonas aeruginosa rods]. Medycyna doswiadczalna i mikrobiologia 20010101
Post-tonsillectomy and adenotonsillectomy morbidity & complications at District Headquarter Hospital Daggar. Journal of Ayub Medical College, Abbottabad : JAMC 20010101
Kinetic studies of clavulanic acid recovery by ion exchange chromatography. Bioseparation 20010101
HLA association of amoxicillin-clavulanate--induced hepatitis. Gastroenterology 19991101
[A clinicobacteriologic study on clavulanic acid/amoxicillin in pediatric acute otitis media]. The Japanese journal of antibiotics 19991001
[A clinicobacteriologic study on clavulanic acid/amoxicillin in pediatric sinusitis]. The Japanese journal of antibiotics 19991001
Susceptibility of multidrug-resistant strains of Mycobacterium tuberculosis to amoxycillin in combination with clavulanic acid and ethambutol. The Journal of antimicrobial chemotherapy 19981201
In vitro activity of antimicrobial combinations against clinical isolates of susceptible and resistant Mycobacterium tuberculosis. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 19980801
[Cholestatic acute hepatitis induced by amoxycillin-clavulanic acid combination. Role of ursodeoxycholic acid in drug-induced cholestasis]. Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva 19980701
Contribution of beta-lactamases to beta-lactam susceptibilities of susceptible and multidrug-resistant Mycobacterium tuberculosis clinical isolates. Antimicrobial agents and chemotherapy 19980601
[Liver damage associated with the combination drug amoxicillin-clavulanic acid (Augmentin)]. Nederlands tijdschrift voor geneeskunde 19970628
[Hepatitis caused by the amoxicillin-clavulanic acid combination. An example of drug-induced biliary hepatotoxicity]. Annales de pathologie 19961201
Intrahepatic cholestasis without hepatitis induced by amoxycillin/clavulanic acid. Journal of clinical gastroenterology 19960901
Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. Archives of internal medicine 19960624
[Acute cholangitis caused by an amoxicillin-clavulanic acid combination]. Gastroenterologie clinique et biologique 19951101
[Cholestatic jaundice after ingestion of amoxicillin and clavulanic acid]. Deutsche medizinische Wochenschrift (1946) 19951006
beta-Lactamase activity in mycobacteria including Mycobacterium avium and suppression of their growth by a beta-lactamase-stable antibiotic. Microbios 19950101
Hepatocellular-cholestatic liver injury due to amoxycillin-clavulanic acid combination. The Clinical investigator 19940801
Antibiotic treatment of experimental endocarditis due to methicillin-resistant Staphylococcus epidermidis. The Journal of infectious diseases 19940701
[Increase in number of seizures following exposure to amoxycillin/clavulanic acid]. Medicina clinica 19921212
Granulomatous hepatitis due to combination of amoxicillin and clavulanic acid. Digestive diseases and sciences 19920101
Amoxicillin-clavulanic acid for treating drug-resistant Mycobacterium tuberculosis. Chest 19910401
Incidence of gallbladder lithiasis after ceftriaxone treatment. The Journal of antimicrobial chemotherapy 19900401
[Cholestatic hepatitis induced by the amoxicillin-clavulanic acid combination. A case and review of the literature]. Gastroenterologie clinique et biologique 19900101
Immunogenicity and allergenicity studies on two beta-lactam structures, a clavam, clavulanic acid, and a carbapenem: structure-activity relationships. International archives of allergy and applied immunology 19880101
Comparison of four beta-lactamase inhibitors in combination with ampicillin against Mycobacterium tuberculosis. The Journal of antimicrobial chemotherapy 19870101
In vitro susceptibility of Mycobacterium tuberculosis, Mycobacterium africanum, Mycobacterium bovis, Mycobacterium avium, Mycobacterium fortuitum, and Mycobacterium chelonae to ticarcillin in combination with clavulanic acid. Antimicrobial agents and chemotherapy 19870101
In vitro activity of amoxicillin in combination with clavulanic acid against Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy 19830901
Properties