1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-(naphthalen-1-yloxy)propan-2-ol
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Determination of naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high-performance liquid chromatography. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015 |
Analysis of energy loss mediated by an alpha-1 blocker in patients with benign prostatic hyperplasia using a virtual urethra processed from an endoscopic video image. | Journal of endourology 20120901 |
Re: Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients. | International journal of urology : official journal of the Japanese Urological Association 20120801 |
Comparison of the effects of four α1-adrenoceptor antagonists on ejaculatory function in rats. | Urology 20120801 |
Excitatory effect of propiverine hydrochloride on urethral activity in rats. | International journal of urology : official journal of the Japanese Urological Association 20120601 |
Effect of chemical stimulation of the medial frontal lobe on the micturition reflex in rats. | The Journal of urology 20120301 |
Benign prostatic hyperplasia: from bench to clinic. | Korean journal of urology 20120301 |
Tamsulosin potently and selectively antagonizes human recombinant α(1A/1D)-adrenoceptors: slow dissociation from the α(1A)-adrenoceptor may account for selectivity for α(1A)-adrenoceptor over α(1B)-adrenoceptor subtype. | Biological & pharmaceutical bulletin 20120101 |
Effects of α-adrenoceptor antagonists on ABCG2/BCRP-mediated resistance and transport. | PloS one 20120101 |
How full is our antihypertensives pipeline? | Journal of pharmacology & pharmacotherapeutics 20120101 |
Comparing efficacy of α1D-receptor antagonist naftopidil and α1A/D-receptor antagonist tamsulosin in management of distal ureteral stones. | World journal of urology 20111201 |
Effects of Spinal and Peripheral Injection of α1A or α1D Adrenoceptor Antagonists on Bladder Activity in Rat Models with or without Bladder Outlet Obstruction. | International neurourology journal 20111201 |
Comparison of prophylactic naftopidil, tamsulosin, and silodosin for 125I brachytherapy-induced lower urinary tract symptoms in patients with prostate cancer: randomized controlled trial. | International journal of radiation oncology, biology, physics 20111115 |
Naftopidil vs silodosin in medical expulsive therapy for ureteral stones: a randomized controlled study in Japanese male patients. | International journal of urology : official journal of the Japanese Urological Association 20111101 |
Effect of 5-alpha Reductase Inhibitor on Storage Symptoms in Patients with Benign Prostatic Hyperplasia. | International neurourology journal 20110901 |
Nerve growth factor level in the prostatic fluid of patients with chronic prostatitis/chronic pelvic pain syndrome is correlated with symptom severity and response to treatment. | BJU international 20110701 |
Predictive factors for the effect of the α1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction. | BJU international 20110701 |
Clinical efficacy of a loading dose of naftopidil for patients with benign prostate hyperplasia. | World journal of urology 20110401 |
α(1)-adrenoceptor blocker naftopidil improves sleep disturbance with reduction in nocturnal urine volume. | World journal of urology 20110401 |
The muscarinic receptor antagonist propiverine exhibits α(1)-adrenoceptor antagonism in human prostate and porcine trigonum. | World journal of urology 20110401 |
Effects of three types of alpha-1 adrenoceptor blocker on lower urinary tract symptoms and sexual function in males with benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20110301 |
[Additional effect of propiverine for naftopidil-resistant nocturia in the patient with benign prostate hypertrophy]. | Hinyokika kiyo. Acta urologica Japonica 20110201 |
An algorithm for medical management in male lower urinary tract symptoms. | Current opinion in urology 20110101 |
Naftopidil, a selective {alpha}1-adrenoceptor antagonist, suppresses human prostate tumor growth by altering interactions between tumor cells and stroma. | Cancer prevention research (Philadelphia, Pa.) 20110101 |
[Efficacy of naftopidil in patients with overactive bladder associated with benign prostatic hyperplasia: prospective randomized controlled study to compare differences in efficacy between morning and evening medication]. | Hinyokika kiyo. Acta urologica Japonica 20110101 |
Clinical feature of men who benefit from dose escalation of naftopidil for lower urinary tract symptoms: a prospective study. | Advances in urology 20110101 |
Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia. | Clinical interventions in aging 20110101 |
Naftopidil for the treatment of urinary symptoms in patients with benign prostatic hyperplasia. | Therapeutics and clinical risk management 20110101 |
Preparation and evaluation of lidocaine hydrochloride in cyclodextrin inclusion complexes for development of stable gel in association with chlorhexidine gluconate for urogenital use. | International journal of nanomedicine 20110101 |
Comparative Molecular Field Analysis (CoMFA) and Comparative Molecular Similarity Indices Analysis (CoMSIA) studies on α(1A)-adrenergic receptor antagonists based on pharmacophore molecular alignment. | International journal of molecular sciences 20110101 |
Re: Long-Term Treatment and Prognostic Factors of alpha1-Blockers for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: A Pilot Study Comparing Naftopidil and Tamsulosin Hydrochloride. | The Journal of urology 20110101 |
Facilitation of expulsion of ureteral stones by addition of α1-blockers to conservative therapy. | Scandinavian journal of urology and nephrology 20101201 |
Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells. | Naunyn-Schmiedeberg's archives of pharmacology 20101201 |
[A randomized controlled study comparing clinical effects of naftopidil and tamsulosin on benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20100901 |
Clinical effect of naftopidil on the quality of life of patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a prospective study. | International journal of urology : official journal of the Japanese Urological Association 20100601 |
[Efficacy of naftopidil for nocturia and consequent sleep disturbance in patients with benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20100401 |
[Effects of alpha1 adrenoceptor antagonist, naftopidil, on non-bacterial chronic pelvic pain syndrome in patients with lower urinary tract syndrome: evaluation of its efficacy using NIH-CPSI after 4-week treatment]. | Hinyokika kiyo. Acta urologica Japonica 20100401 |
Re: Efficacy of selective alpha1D-blocker naftopidil as medical expulsive therapy for distal ureteral stones. X. Sun, L. He, W. Ge and J. Lv. J Urol 2009; 181: 1716-1720. | The Journal of urology 20100301 |
Long-term treatment and prognostic factors of alpha 1-blockers for lower urinary tract symptoms associated with benign prostatic hyperplasia: a pilot study comparing naftopidil and tamsulosin hydrochloride. | Scandinavian journal of urology and nephrology 20100201 |
Effects of silodosin and naftopidil on the distal ureter and cardiovascular system in anesthetized dogs: comparison of potential medications for distal ureteral stone passage. | The Journal of urology 20100101 |
A prospective, randomized, controlled, multicenter study of naftopidil for treatment of male lower urinary tract symptoms associated with benign prostatic hyperplasia: 75 mg once daily in the evening compared to 25 mg thrice daily. | Urologia internationalis 20100101 |
The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction. | Advances in urology 20100101 |
Naftopidil for the treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia. | The Cochrane database of systematic reviews 20091007 |
Prostate growth inhibition by subtype-selective alpha(1)-adrenoceptor antagonist naftopidil in benign prostatic hyperplasia. | The Prostate 20091001 |
Mechanical function and gene expression of alpha(1)-adrenoceptor subtypes in dog intravesical ureter. | Urology 20090801 |
Efficacy of selective alpha1D-blocker naftopidil as medical expulsive therapy for distal ureteral stones. | The Journal of urology 20090401 |
[The clinical efficacy and safety of naftopidil 75 mg on benign prostatic hyperplasia patients with moderate or severe urinary disturbance]. | Hinyokika kiyo. Acta urologica Japonica 20090401 |
1,3-Dioxolane-based ligands as rigid analogues of naftopidil: structure-affinity/activity relationships at alpha1 and 5-HT1A receptors. | ChemMedChem 20090301 |
Clinical efficacy of naftopidil on lower urinary tract symptoms after radical prostatectomy. | International journal of urology : official journal of the Japanese Urological Association 20090301 |
Role of alpha1-adrenergic receptors in detrusor overactivity induced by cold stress in conscious rats. | Neurourology and urodynamics 20090101 |
Usefulness of naftopidil for dysuria in benign prostatic hyperplasia and its optimal dose--comparison between 75 and 50 mg. | Urologia internationalis 20090101 |
Naftopidil and propiverine hydrochloride for treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia and concomitant overactive bladder: a prospective randomized controlled study. | Scandinavian journal of urology and nephrology 20090101 |
Ejaculatory disorders caused by alpha-1 blockers for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: comparison of naftopidil and tamsulosin in a randomized multicenter study. | Urologia internationalis 20090101 |
Naftopidil versus tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia with special reference to the storage symptom: a prospective randomized controlled study. | International journal of urology : official journal of the Japanese Urological Association 20081201 |
Alpha antagonists and intraoperative floppy iris syndrome: A spectrum. | Clinical ophthalmology (Auckland, N.Z.) 20081201 |
Effect of naftopidil on nocturia after failure of tamsulosin. | Urology 20081101 |
Alpha-adrenoceptor blockade modifies neurally induced atrial arrhythmias. | American journal of physiology. Regulatory, integrative and comparative physiology 20081001 |
[Effectiveness and safety of naftopidil for benign prostatic hyperplasia patients with overactive bladder symptoms]. | Zhonghua nan ke xue = National journal of andrology 20081001 |
Clinical effect of alpha 1D/A adrenoceptor inhibitor naftopidil on benign prostatic hyperplasia: an international prostate symptom score and King's Health Questionnaire assessment. | International journal of urology : official journal of the Japanese Urological Association 20080801 |
Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration. | Neurologia medico-chirurgica 20080501 |
[Evaluation of supplemental administration of Eviprostat in patients with benign prostatic hyperplasia with persistent symptoms following treatment with alpha1-adrenoceptor blocker]. | Hinyokika kiyo. Acta urologica Japonica 20080501 |
Expression of alpha1-adrenoceptor subtype mRNA as a predictor of the efficacy of subtype selective alpha1-adrenoceptor antagonists in the management of benign prostatic hyperplasia. | The Journal of urology 20080301 |
[Clinical evaluation of supplemental administration of flavoxate hydrochloride in benign prostatic hyperplasia patients with nocturia resistant to an alpha1-adrenoceptor blocker]. | Hinyokika kiyo. Acta urologica Japonica 20080301 |
In vivo study on the effects of alpha1-adrenoceptor antagonists on intraurethral pressure in the prostatic urethra and intraluminal pressure in the vas deferens in male dogs. | European journal of pharmacology 20080202 |
Naftopidil, a selective alpha-1 adrenoceptor antagonist, inhibits growth of human prostate cancer cells by G1 cell cycle arrest. | International journal of cancer 20080115 |
Differential effects of prazosin and naftopidil on pelvic blood flow and nitric oxide synthase levels in spontaneously hypertensive rats. | Journal of receptor and signal transduction research 20080101 |
Effects of propiverine and naftopidil on the urinary ATP level and bladder activity after bladder stimulation in rats. | Neuroscience letters 20071218 |
Change of expression levels of alpha1-adrenoceptor subtypes by administration of alpha1d-adrenoceptor-subtype-selective antagonist naftopidil in benign prostate hyperplasia patients. | The Prostate 20070901 |
[Comparison of different drugs on the treatment of benign prostate hyperplasia]. | Zhonghua wai ke za zhi [Chinese journal of surgery] 20070715 |
[A comparative study assessing clinical effects of naftopidil and tamsulosin hydrochloride on benign prostatic hyperplasia with overactive bladder]. | Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20070701 |
[Design, synthesis and vasorelaxant activity of R, S-1-(substituted phenyl)-4-[3-(naphtha-1-yl-oxy)-2-hydroxypropyl]-piperazine derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20070701 |
Zinc(II) perchlorate hexahydrate catalyzed opening of epoxide ring by amines: applications to synthesis of (RS)/(R)-propranolols and (RS)/(R)/(S)-naftopidils. | The Journal of organic chemistry 20070511 |
[Giant prostate carcinoma treated effectively with endocrine therapy: case report]. | Hinyokika kiyo. Acta urologica Japonica 20070201 |
Crossover comparison study on the therapeutic effects of tamsulosin hydrochloride and naftopidil in lower urinary tract symptoms associated with benign prostatic hyperplasia. | Drugs of today (Barcelona, Spain : 1998) 20070201 |
Incidence of intraoperative floppy iris syndrome in patients on either systemic or topical alpha(1)-adrenoceptor antagonist. | American journal of ophthalmology 20070101 |
[The effectiveness of naftopidil in patients with benign prostatic hyperplasia evaluated by QOL index]. | Hinyokika kiyo. Acta urologica Japonica 20070101 |
Short-term efficacy and long-term compliance/treatment failure of the alpha1 blocker naftopidil for patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. | Scandinavian journal of urology and nephrology 20070101 |
Search for new alpha1a-adrenoceptor-selective antagonist for treating lower urinary tract symptoms associated with benign prostatic hyperplasia. | Indian journal of urology : IJU : journal of the Urological Society of India 20070101 |
Naftopidil monotherapy vs naftopidil and an anticholinergic agent combined therapy for storage symptoms associated with benign prostatic hyperplasia: A prospective randomized controlled study. | International journal of urology : official journal of the Japanese Urological Association 20061001 |
Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. | International journal of urology : official journal of the Japanese Urological Association 20061001 |
Effect of tamsulosin on spontaneous bladder contraction in conscious rats with bladder outlet obstruction: comparison with effect on intraurethral pressure. | European journal of pharmacology 20060918 |
[The study of the in vivo-in vitro correlation of the naftopidil sustained-release tablet in dog]. | Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi 20060801 |
Comparison of 25 and 75 mg/day naftopidil for lower urinary tract symptoms associated with benign prostatic hyperplasia: a prospective, randomized controlled study. | International journal of urology : official journal of the Japanese Urological Association 20060701 |
Comparison of two alpha1-adrenoceptor antagonists, naftopidil and tamsulosin hydrochloride, in the treatment of lower urinary tract symptoms with benign prostatic hyperplasia: a randomized crossover study. | BJU international 20060401 |
Emerging drug therapies for benign prostatic hyperplasia. | Expert opinion on emerging drugs 20060301 |
[Alpha1-adrenoceptor subtypes and alpha1-adrenoceptor antagonists]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Latest frontiers in pharmacotherapy for benign prostatic hyperplasia]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Alpha1-adrenoceptor subtype selectivity and organ specificity of silodosin (KMD-3213)]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Effects of silodosin (KMD-3213) on phenylephrine-induced increase in intraurethral pressure and blood pressure in rats--study of the selectivity for lower urinary tract]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060301 |
[Clinical application of alpha1 adrenoceptor antagonist Naftopidil to the treatment of chronic non-bacterial prostatitis]. | Zhonghua nan ke xue = National journal of andrology 20060301 |
In vivo studies on the effects of alpha1-adrenoceptor antagonists on pupil diameter and urethral tone in rabbits. | Naunyn-Schmiedeberg's archives of pharmacology 20060201 |
Activation of alpha1D adrenergic receptors in the rat urothelium facilitates the micturition reflex. | The Journal of urology 20060101 |
Clinical efficacy of an alpha1A/D-adrenoceptor blocker (naftopidil) on overactive bladder symptoms in patients with benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20060101 |
Improvement of bladder storage function by alpha1-blocker depends on the suppression of C-fiber afferent activity in rats. | Neurourology and urodynamics 20060101 |
[Metabolites of R, S-1-(2-methoxyphenyl)-4-[3-(naphtha-1-yl-oxy)-2-hydroxypropyl]-piperazin in rat plasma]. | Yao xue xue bao = Acta pharmaceutica Sinica 20060101 |
Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for the obstructive component of benign prostatic hyperplasia. | Neurourology and urodynamics 20060101 |
[Ejaculatory disorder by alpha-1 adrenoceptor antagonist in patients with benign prostatic hyperplasia; retrospective comparison between naftopidil and tamsulosin]. | Hinyokika kiyo. Acta urologica Japonica 20051101 |
Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia. | The Journal of urology 20050901 |
Comparison of tamsulosin and naftopidil for efficacy and safety in the treatment of benign prostatic hyperplasia: a randomized controlled trial. | BJU international 20050901 |
Flow injection chemiluminescence determination of naftopidil based on potassium permanganate oxidation in the presence of formaldehyde or formic acid. | Analytical and bioanalytical chemistry 20050201 |
Effects of tamsulosin on hypogastric nerve stimulation-induced intraurethral pressure elevation in male and female dogs under anesthesia. | European journal of pharmacology 20040830 |
Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia. | International journal of urology : official journal of the Japanese Urological Association 20040701 |
[Etiology of nocturia and clinical efficacy of naftopidil on nocturia in patients with benign prostatic hyperplasia--analysis of frequency volume charts]. | Hinyokika kiyo. Acta urologica Japonica 20040501 |
Usefulness of tamsulosin hydrochloride and naftopidil in patients with urinary disturbances caused by benign prostatic hyperplasia: a comparative, randomized, two-drug crossover study. | International journal of urology : official journal of the Japanese Urological Association 20031101 |
[Clinical effects of naftopidil on nocturia associated with benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20030801 |
Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and 1D adrenergic receptor antagonists, on bladder activity in rats. | The Journal of urology 20030401 |
[Long-term efficacy of naftopidil for treatment of lower urinary tract symptoms with benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20030401 |
Effects of intrathecal injection of tamsulosin and naftopidil, alpha-1A and -1D adrenergic receptor antagonists, on bladder activity in rats. | Neuroscience letters 20020802 |
alpha-Adrenoceptor antagonists in the treatment of benign prostate hyperplasia. | Pharmacology 20020701 |
The use of modified simplex method to optimize the room temperature phosphorescence variables in the determination of an antihypertensive drug. | Talanta 20020610 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
[A comparative study assessing clinical effects of naftopidil and tamsulosin hydrochloride on benign prostatic hyperplasia]. | Hinyokika kiyo. Acta urologica Japonica 20020101 |
Differential actions of naftopidil, doxazosin and nifedipine on platelet thromboxane generation and platelet-derived growth factor efflux in vitro. | Platelets 20020101 |
[The clinical efficacy of Naftopidil tablet in the treatment of benign prostatic hyperplasia]. | Zhonghua nan ke xue = National journal of andrology 20020101 |
Non-protected fluid room-temperature phosphorimetric procedure for the direct determination of naftopidil in biological fluids. | Fresenius' journal of analytical chemistry 20011201 |
[Pharmacokinetics of high-dosage naftopidil capsules in dogs]. | Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20011028 |
[Improving bioavailability of naftopidil by using bioadhesion in dogs]. | Yao xue xue bao = Acta pharmaceutica Sinica 20010501 |
Determination of carvedilol in human cardiac tissue by high-performance liquid chromatography. | Journal of chromatographic science 20010301 |
Direct determination of naftopidil by non-protected fluid room temperature phosphorescence. | The Analyst 20010201 |
Vascular alpha1-adrenoceptor subtype selectivity and alpha1-blocker-induced orthostatic hypotension. | Japanese journal of pharmacology 19980501 |