Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.

Bioorganic & medicinal chemistry letters 20120615

Orexin receptor type-1 antagonist SB-334867 inhibits the development of morphine analgesic tolerance in rats.

Peptides 20120501

A septal-hypothalamic pathway drives orexin neurons, which is necessary for conditioned cocaine preference.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20120328

Orexin-1 receptor mediation of cocaine seeking in male and female rats.

The Journal of pharmacology and experimental therapeutics 20120301

OX1 orexin/hypocretin receptor activation of phospholipase D.

British journal of pharmacology 20120201

Hypocretin/orexin signaling in the hypothalamic paraventricular nucleus is essential for the expression of nicotine withdrawal.

Biological psychiatry 20120201

Arousal effects of orexin A on acute alcohol intoxication-induced coma in rats.

Neuropharmacology 20120201

Effects of orexin and glucose microinjected into the hypothalamic paraventricular nucleus on gastric acid secretion in conscious rats.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20120201

Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.

Brain research 20120111

Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal.

PloS one 20120101

Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.

PloS one 20120101

Evidence for the role of hindbrain orexin-1 receptors in the control of meal size.

American journal of physiology. Regulatory, integrative and comparative physiology 20111201

An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20111102

The influence of orexins on the firing rate and pattern of rat intergeniculate leaflet neurons--electrophysiological and immunohistological studies.

The European journal of neuroscience 20111101

Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20111012

Hcrtr1 and 2 signaling differentially regulates depression-like behaviors.

Behavioural brain research 20110923

Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period.

Behavioural brain research 20110801

The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.

Neuroscience letters 20110708

Stimulatory effect of intracerebroventricular administration of orexin A on food intake in the zebrafish, Danio rerio.

Peptides 20110701

Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking.

The international journal of neuropsychopharmacology 20110601

The orexin₁ receptor antagonist SB-334867 dissociates the motivational properties of alcohol and sucrose in rats.

Brain research 20110519

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.

Bioorganic & medicinal chemistry letters 20110515

SB-334867-A, a selective orexin-1 receptor antagonist, enhances taste aversion learning and blocks taste preference learning in rats.

Pharmacology, biochemistry, and behavior 20110501

Intraventricular administration of neuropeptide S has reward-like effects.

European journal of pharmacology 20110501

Involvement of the orexin/hypocretin system in ethanol conditioned place preference.

Psychopharmacology 20110401

Orexin-1 receptor antagonist SB-334867 reduces the acquisition and expression of cocaine-conditioned reinforcement and the expression of amphetamine-conditioned reward.

Behavioural pharmacology 20110401

Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

British journal of pharmacology 20110301

A role for orexin in central vestibular motor control.

Neuron 20110224

Chemical stimulation of the lateral hypothalamus induces conditioned place preference in rats: Involvement of OX1 and CB1 receptors in the ventral tegmental area.

Behavioural brain research 20110202

Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin₁ receptors.

British journal of pharmacology 20110201

Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.

British journal of pharmacology 20110201

Effects of orexin-A on propofol anesthesia in rats.

Journal of anesthesia 20110201

Orexins in the midline thalamus are involved in the expression of conditioned place aversion to morphine withdrawal.

Physiology & behavior 20110110

Glutamatergic regulation of ghrelin-induced activation of the mesolimbic dopamine system.

Addiction biology 20110101

Orexin-1 receptor mediates long-term potentiation in the dentate gyrus area of freely moving rats.

Behavioural brain research 20110101

Effect of orexin-A on phagocytic activity of peritoneal macrophage in starved rats.

Cellular immunology 20110101

Central orexin-A increases gastric motility in rats.

Peptides 20101101

Antagonism of orexin type 1 receptors in the locus coeruleus attenuates signs of naloxone-precipitated morphine withdrawal in rats.

Neuroscience letters 20101004

Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness.

Sleep 20101001

The endogenous actions of hypothalamic peptides on brown adipose tissue thermogenesis in the rat.

Endocrinology 20100901

Opposite roles of dopamine and orexin in quinpirole-induced excessive drinking: a rat model of psychotic polydipsia.

Psychopharmacology 20100801

The modulation of orexin A on HCN currents of pyramidal neurons in mouse prelimbic cortex.

Cerebral cortex (New York, N.Y. : 1991) 20100701

Thermal nociception is decreased by hypocretin-1 and an adenosine A1 receptor agonist microinjected into the pontine reticular formation of Sprague Dawley rat.

The journal of pain : official journal of the American Pain Society 20100601

Endogenous orexin-A modulates gastric motility by peripheral mechanisms in rats.

Peptides 20100601

Ghrelin increases the rewarding value of high-fat diet in an orexin-dependent manner.

Biological psychiatry 20100501

The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats.

Neuroscience 20100428

Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement.

Biological psychiatry 20100415

Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA.

Psychopharmacology 20100401

Orexin mediates morphine place preference, but not morphine-induced hyperactivity or sensitization.

Brain research 20100304

Orexins excite neurons of the rat cerebellar nucleus interpositus via orexin 2 receptors in vitro.

Cerebellum (London, England) 20100301

Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20100210

The orexin receptor 1 (OX1R) in the rostral medullary raphe contributes to the hypercapnic chemoreflex in wakefulness, during the active period of the diurnal cycle.

Respiratory physiology & neurobiology 20100131

Orexins activates protein kinase C-mediated Ca(2+) signaling in isolated rat primary sensory neurons.

Physiological research 20100101

Orexin/hypocretin is necessary for context-driven cocaine-seeking.

Neuropharmacology 20100101

The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization.

Neurochemistry international 20100101

The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system.

The European journal of neuroscience 20100101

Halothane-induced hypnosis is not accompanied by inactivation of orexinergic output in rodents.

Anesthesiology 20091101

Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats.

Psychopharmacology 20091001

Orexin-A acts on the paraventricular nucleus of the midline thalamus to inhibit locomotor activity in rats.

Pharmacology, biochemistry, and behavior 20091001

Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20090909

Persistent increase of alcohol-seeking evoked by neuropeptide S: an effect mediated by the hypothalamic hypocretin system.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090801

Orexin-stimulated MAP kinase cascades are activated through multiple G-protein signalling pathways in human H295R adrenocortical cells: diverse roles for orexins A and B.

The Journal of endocrinology 20090801

Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking.

The European journal of neuroscience 20090801

Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol--preferring Sprague--Dawley rats.

Alcohol (Fayetteville, N.Y.) 20090801

Orexin A modulates neuronal activity of the rodent suprachiasmatic nucleus in vitro.

The European journal of neuroscience 20090701

Antagonism of orexin receptor-1 in the retrotrapezoid nucleus inhibits the ventilatory response to hypercapnia predominantly in wakefulness.

The Journal of physiology 20090501

Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus.

Regulatory peptides 20090410

The role of spinal orexin-1 receptors in posterior hypothalamic modulation of neuropathic pain.

Neuroscience 20090410

Orexin type 1 receptor antagonist SB 334867 inhibits the central histamine-induced resuscitating effect in rats subjected to haemorrhagic shock.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20090401

The effects of benzodiazepines on urotensin II-stimulated norepinephrine release from rat cerebrocortical slices.

Anesthesia and analgesia 20090401

Short food deprivation inhibits orexin receptor 1 expression and orexin-A induced intracellular calcium signaling in acutely isolated duodenal enterocytes.

American journal of physiology. Gastrointestinal and liver physiology 20090301

Role of the ventromedial hypothalamic orexin-1 receptors in regulation of gastric Acid secretion in conscious rats.

Journal of neuroendocrinology 20090301

Orexin A attenuates unconditioned sexual motivation in male rats.

Pharmacology, biochemistry, and behavior 20090201

Orexin A decreases ketamine-induced anesthesia time in the rat: the relevance to brain noradrenergic neuronal activity.

Anesthesia and analgesia 20090201

I.c.v. administration of orexin-A induces an antidepressive-like effect through hippocampal cell proliferation.

Neuroscience 20081210

Insular hypocretin transmission regulates nicotine reward.

Proceedings of the National Academy of Sciences of the United States of America 20081209

Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.

Brain research 20080811

Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell.

Biological psychiatry 20080801

Orexins stimulate steroidogenic acute regulatory protein expression through multiple signaling pathways in human adrenal H295R cells.

Endocrinology 20080801

Orexin-2 receptors inhibit primary afferent fiber-evoked responses of ventral roots in the neonatal rat isolated spinal cord.

Brain research 20080707

Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats.

Psychopharmacology 20080701

Reinvestigation of the effect of orexin A on catecholamine release from adrenal chromaffin cells.

Neuroscience letters 20080509

Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats.

British journal of pharmacology 20080501

Role of orexin receptors in the nucleus accumbens in dopamine-dependent turning behaviour of rats.

Neuropharmacology 20080301

Role of the orexinergic system in acute haemorrhage in the rat.

Neuroscience letters 20080220

The effect of antagonization of orexin 1 receptors in CA1 and dentate gyrus regions on memory processing in passive avoidance task.

Behavioural brain research 20080211

Orexin affects dorsal root ganglion neurons: a mechanism for regulating the spinal nociceptive processing.

Physiological research 20080101

Food-elicited increases in cortical acetylcholine release require orexin transmission.

Neuroscience 20071109

The orexin-1 antagonist SB-334867 blocks antipsychotic treatment emergent catalepsy: implications for the treatment of extrapyramidal symptoms.

Schizophrenia bulletin 20071101

Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice.

Journal of applied physiology (Bethesda, Md. : 1985) 20071101

Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation.

American journal of physiology. Endocrinology and metabolism 20071001

Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A.

American journal of physiology. Gastrointestinal and liver physiology 20070801

Disinhibition of perifornical hypothalamic neurones activates noradrenergic neurones and blocks pontine carbachol-induced REM sleep-like episodes in rats.

The Journal of physiology 20070715

The orexin-1 receptor antagonist SB-334867 blocks the effects of antipsychotics on the activity of A9 and A10 dopamine neurons: implications for antipsychotic therapy.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070401

Role of dorsal vagal motor nucleus orexin-receptor-1 in glycemic responses to acute versus repeated insulin administration.

Neuropeptides 20070401

The selective orexin 1 receptor antagonist SB-334867-A impairs acquisition and consolidation but not retrieval of spatial memory in Morris water maze.

Peptides 20070301

Modulation of nociceptive dural input to the trigeminal nucleus caudalis via activation of the orexin 1 receptor in the rat.

The European journal of neuroscience 20061101

The effect of orexins on intestinal motility in vitro in fed and fasted rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101

Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task.

Behavioural brain research 20061002

Orexin A affects ascending contraction depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum.

Neuropharmacology 20060901

Hypocretin-1 dose-dependently modulates maternal behaviour in mice.

Journal of neuroendocrinology 20060801

Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor.

Journal of peptide science : an official publication of the European Peptide Society 20060701

The orexin system regulates alcohol-seeking in rats.

British journal of pharmacology 20060701

Orexins increase cortical acetylcholine release and electroencephalographic activation through orexin-1 receptor in the rat basal forebrain during isoflurane anesthesia.

Anesthesiology 20060501

Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.

Neuron 20060216

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111

Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.

Proceedings of the National Academy of Sciences of the United States of America 20051227

Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity.

Peptides 20051101

Lack of interaction between orexinergic and alpha2-adrenergic neuronal systems in rat cerebrocortical slices.

Neuroscience letters 20051014

Orexin A in the nucleus accumbens stimulates feeding and locomotor activity.

Brain research 20050719

Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats.

Brain research 20050517

Satiety enhancement by selective orexin-1 receptor antagonist SB-334867: influence of test context and profile comparison with CCK-8S.

Behavioural brain research 20050507

Anorexia and weight loss in male rats 24 h following single dose treatment with orexin-1 receptor antagonist SB-334867.

Behavioural brain research 20050227

Hypocretinergic control of spinal cord motoneurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20040609

Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus.

Neuropharmacology 20040601

Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo.

Peptides 20040601

Hypothalamus-brain stem circuitry responsible for vagal efferent signaling to the pancreas evoked by hypoglycemia in rat.

Journal of neurophysiology 20040401

Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats.

American journal of physiology. Endocrinology and metabolism 20040401

Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats.

Physiology & behavior 20040301

Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain.

The Journal of pharmacology and experimental therapeutics 20031201

Physiological regulation and NO-dependent inhibition of migrating myoelectric complex in the rat small bowel by OXA.

American journal of physiology. Gastrointestinal and liver physiology 20031001

Hypocretin-1 causes G protein activation and increases ACh release in rat pons.

The European journal of neuroscience 20031001

Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats.

Brain research 20030815

Central orexin A has site-specific effects on luteinizing hormone release in female rats.

Endocrinology 20030701

Orexins induce increased excitability and synchronisation of rat sympathetic preganglionic neurones.

The Journal of physiology 20030615

Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat.

Neuroscience letters 20030508

Orexinergic neurons and barbiturate anesthesia.

Neuroscience 20030101

Involvement of cholinergic neurons in orexin-induced contraction of guinea pig ileum.

European journal of pharmacology 20020927

Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test.

British journal of pharmacology 20020901

Orexins and the treatment of obesity.

European journal of pharmacology 20020412

Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice.

Regulatory peptides 20020315

SB-334867-A antagonises orexin mediated excitation in the locus coeruleus.

Neuropharmacology 20020101

1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.

Bioorganic & medicinal chemistry letters 20010723

Orexin-A, an hypothalamic peptide with analgesic properties.

Pain 20010501

SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats.

The European journal of neuroscience 20010401

Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity.

Psychopharmacology 20010101