sales@angenesci.com
Login | Register
logo
Structures Search
Home Other Building Blocks Monomethyl Auristatin F

Monomethyl Auristatin F

CAS No.:
745017-94-1
Catalog Number:
AG00359W
Molecular Formula:
C39H65N5O8
Molecular Weight:
731.9621
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
98+%
1 week
United States
$63
- +
Product Description
Catalog Number:
AG00359W
Chemical Name:
Monomethyl Auristatin F
CAS Number:
745017-94-1
Molecular Formula:
C39H65N5O8
Molecular Weight:
731.9621
MDL Number:
MFCD25976742
IUPAC Name:
(2S)-2-[[(2R,3R)-3-methoxy-3-[(2S)-1-[(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl-[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(methylamino)butanoyl]amino]butanoyl]amino]heptanoyl]pyrrolidin-2-yl]-2-methylpropanoyl]amino]-3-phenylpropanoic acid
InChI:
InChI=1S/C39H65N5O8/c1-12-25(6)34(43(9)38(48)33(24(4)5)42-37(47)32(40-8)23(2)3)30(51-10)22-31(45)44-20-16-19-29(44)35(52-11)26(7)36(46)41-28(39(49)50)21-27-17-14-13-15-18-27/h13-15,17-18,23-26,28-30,32-35,40H,12,16,19-22H2,1-11H3,(H,41,46)(H,42,47)(H,49,50)/t25-,26+,28-,29-,30+,32-,33-,34-,35+/m0/s1
InChI Key:
MFRNYXJJRJQHNW-DEMKXPNLSA-N
SMILES:
CN[C@H](C(=O)N[C@H](C(=O)N(C([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)C)OC)OC)[C@H](CC)C)C)C(C)C)C(C)C
Properties
Complexity:
1160  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0
Exact Mass:
731.483g/mol
Formal Charge:
0
Heavy Atom Count:
52  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
731.976g/mol
Monoisotopic Mass:
731.483g/mol
Rotatable Bond Count:
21  
Topological Polar Surface Area:
167A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.1  
Literature
Title Journal
Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues. Analytical chemistry 20120320
Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats. Bioconjugate chemistry 20111019
Antibody-drug conjugates for the treatment of non-Hodgkin's lymphoma: target and linker-drug selection. Cancer research 20090315
A human antibody-drug conjugate targeting EphA2 inhibits tumor growth in vivo. Cancer research 20081115
Anti-CD22-MCC-DM1 and MC-MMAF conjugates: impact of assay format on pharmacokinetic parameters determination. Bioconjugate chemistry 20080801
Properties