Homopiperazine
| Title | Journal |
|---|---|
| Computational studies of novel chymase inhibitors against cardiovascular and allergic diseases: mechanism and inhibition. | Chemical biology & drug design 20121201 |
| Exploration of ring size in a series of cyclic vicinal diamines with σ₁ receptor affinity. | Bioorganic & medicinal chemistry letters 20120901 |
| Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy. | ACS combinatorial science 20120813 |
| Reaction of homopiperazine with endogenous formaldehyde: a carbon hydrogen addition metabolite/product identified in rat urine and blood. | Drug metabolism and disposition: the biological fate of chemicals 20120801 |
| Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats. | Pharmacology, biochemistry, and behavior 20120801 |
| Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties. | Bioorganic & medicinal chemistry letters 20120701 |
| 1,4-Ditosyl-1,4-diazepane. | Acta crystallographica. Section E, Structure reports online 20120601 |
| Ethyl 2-(7-oxo-3,5-diphenyl-1,4-diaze-pan-2-yl)acetate. | Acta crystallographica. Section E, Structure reports online 20120401 |
| Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol. | Bioorganic & medicinal chemistry 20120301 |
| Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs. | Journal of medicinal chemistry 20111124 |
| Methyl (9aR*,10S*,11R*,13aS*,13bS*)-9-oxo-6,7,9,9a,10,11-hexa-hydro-5H,13bH-11,13a-ep-oxy-pyrrolo-[2',1':3,4][1,4]diazepino[2,1-a]isoindole-10-carboxyl-ate. | Acta crystallographica. Section E, Structure reports online 20111101 |
| N-substituted homopiperazine barbiturates as gelatinase inhibitors. | Bioorganic & medicinal chemistry 20110815 |
| Homopiperazine-1,4-diium bis-[hexa-aqua-cobalt(II)] tris-ulfate. | Acta crystallographica. Section E, Structure reports online 20110801 |
| Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters. | Bioorganic & medicinal chemistry letters 20110715 |
| Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines. | Bioorganic & medicinal chemistry 20110501 |
| 1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability. | Bioorganic & medicinal chemistry letters 20110401 |
| Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄. | ACS combinatorial science 20110314 |
| Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer. | Journal of medicinal chemistry 20110310 |
| Mechanistic insight into the reactivity of oxotransferases by novel asymmetric dioxomolybdenum(VI) model complexes. | Chemistry (Weinheim an der Bergstrasse, Germany) 20110110 |
| Lipopolysaccharide-Deficient Brucella Variants Arise Spontaneously during Infection. | Frontiers in microbiology 20110101 |
| Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. | PloS one 20110101 |
| Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations. | PloS one 20110101 |
| A series of Cu(II)-azide polymers of Cu6 building units and the role of chelating diamine in controlling their dimensionality: synthesis, structures, and magnetic behavior. | Inorganic chemistry 20101115 |
| Bis(homopiperazine-1,4-diium) cyclo-tetra-phosphate-telluric acid (1/2). | Acta crystallographica. Section E, Structure reports online 20101101 |
| Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation. | Bioorganic & medicinal chemistry letters 20100801 |
| Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup. | The Journal of organic chemistry 20100702 |
| Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers. | Bioorganic & medicinal chemistry letters 20100501 |
| Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists. | Bioorganic & medicinal chemistry letters 20100401 |
| Tertiary skipped diynes: a pluripotent building block for the modular and diversity-oriented synthesis of nitrogen heterocycles. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100315 |
| A series of peroxomanganese(III) complexes supported by tetradentate aminopyridyl ligands: detailed spectroscopic and computational studies. | Journal of the American Chemical Society 20100303 |
| Dramatic increase of selectivity for heavy lanthanide(III) cations by tuning the flexibility of polydentate chelators. | Inorganic chemistry 20100118 |
| Synthesis and evaluation of (S,S)-N,N'-bis-[3-(2,2',6,6'-tetramethylbenzhydryloxy)-2-hydroxy-propyl]-ethylenediamine (S2824) analogs with anti-tuberculosis activity. | Bioorganic & medicinal chemistry letters 20091101 |
| Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks. | The Journal of organic chemistry 20090807 |
| Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association. | Archiv der Pharmazie 20090801 |
| Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats. | ChemMedChem 20090701 |
| Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound. | Bioorganic & medicinal chemistry letters 20090515 |
| User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls. | Organic & biomolecular chemistry 20090507 |
| 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity. | European journal of medicinal chemistry 20090201 |
| Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors. | Bioorganic & medicinal chemistry letters 20081215 |
| Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs. | Bioorganic & medicinal chemistry 20081115 |
| Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases. | Bioorganic & medicinal chemistry letters 20070515 |
| N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors. | Journal of enzyme inhibition and medicinal chemistry 20061201 |
| Identification of new diamine scaffolds with activity against Mycobacterium tuberculosis. | Journal of medicinal chemistry 20060601 |
| Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan acetylcholine binding protein (AChBP). | Farmaco (Societa chimica italiana : 1989) 20050401 |
| [High throughput screening of pharmacokinetics and metabolism in drug discovery (II)--investigation on in vitro and in vivo correlation in drug metabolism screening]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050101 |
| Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives. | Bioorganic & medicinal chemistry letters 20041101 |
| Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives. | Bioorganic & medicinal chemistry 20041015 |
| Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity. | Bioorganic & medicinal chemistry 20040501 |
| Exploration of composition space in templated uranium sulfates. | Inorganic chemistry 20031103 |
| A new class of spermidine-derived alkaloids. | Organic letters 20030807 |
| Trypanocidal activity of conformationally restricted pentamidine congeners. | Journal of medicinal chemistry 20030313 |
| Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives. | Journal of medicinal chemistry 20020926 |
| 6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies. | Journal of medicinal chemistry 20020829 |
| New mu-opioid receptor agonists with piperazine moiety. | Chemical & pharmaceutical bulletin 20011001 |
| Subtle bite-angle influences on N(2)S(2)Ni complexes. | Inorganic chemistry 20010702 |
| Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies. | Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010601 |