Home Other Building Blocks Galanthamine hydrobromide

Galanthamine hydrobromide

CAS No.:
1953-04-4
Catalog Number:
AG0034YM
Molecular Formula:
C17H22BrNO3
Molecular Weight:
368.2655
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
100mg
95%
In Stock USA
United States
$248
- +
250mg
95%
In Stock USA
United States
$495
- +
Product Description
Catalog Number:
AG0034YM
Chemical Name:
Galanthamine hydrobromide
CAS Number:
1953-04-4
Molecular Formula:
C17H22BrNO3
Molecular Weight:
368.2655
MDL Number:
MFCD00067672
IUPAC Name:
(1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetracyclo[8.6.1.01,12.06,17]heptadeca-6(17),7,9,15-tetraen-14-ol;hydrobromide
InChI:
InChI=1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
InChI Key:
QORVDGQLPPAFRS-XPSHAMGMSA-N
SMILES:
COc1ccc2c3c1O[C@@H]1[C@@]3(CCN(C2)C)C=C[C@@H](C1)O.Br
EC Number:
217-780-5
UNII:
MJ4PTD2VVW
Properties
Complexity:
440  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
367.078g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
368.271g/mol
Monoisotopic Mass:
367.078g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
41.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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Electroencephalographic effects of galantamine in major depressive disorder. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society 20090601
A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder. Journal of clinical psychopharmacology 20090601
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An unusual case of nightmares with galantamine. Journal of the American Geriatrics Society 20090301
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A double-blind comparison of galantamine hydrobromide ER and placebo in Parkinson disease. Journal of neurology, neurosurgery, and psychiatry 20090101
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A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease. International journal of geriatric psychiatry 20080201
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Galantamine in frontotemporal dementia and primary progressive aphasia. Dementia and geriatric cognitive disorders 20080101
First administration of cytidine diphosphocholine and galantamine in schizophrenia: a sustained alpha7 nicotinic agonist strategy. Clinical neuropharmacology 20080101
Effects of galantamine on measures of attention: results from 2 clinical trials in Alzheimer disease patients with comparisons to donepezil. Alzheimer disease and associated disorders 20080101
Analysis of galanthamine-type alkaloids by capillary gas chromatography-mass spectrometry in plants. Phytochemical analysis : PCA 20080101
New rapid validated HPTLC method for the determination of galanthamine in Amaryllidaceae plant extracts. Phytochemical analysis : PCA 20080101
The clinical significance of plasmatic amyloid A{beta}-40 peptide levels in Alzheimer's disease patients treated with galantamine. American journal of Alzheimer's disease and other dementias 20080101
One-week dose titration of extended release galantamine in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association 20080101
Review of issue: studies on veterans, a useful pain scale, and plasma amyloid levels as a predictor of response to medications. American journal of Alzheimer's disease and other dementias 20080101
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Discontinuing Alzheimer's disease drug therapy: why, when, and how. Director (Cincinnati, Ohio) 20080101
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An update on the pharmacology of galantamine. Expert opinion on investigational drugs 20071201
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Beyond in vitro data: a review of in vivo evidence regarding the allosteric potentiating effect of galantamine on nicotinic acetylcholine receptors in Alzheimer's neuropathology. Journal of Alzheimer's disease : JAD 20070701
High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
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Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezil. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070601
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Comparative analysis of mortality in patients with Alzheimer's disease treated with donepezil and galantamine. Age and ageing 20070301
A 12-week, double-blind, placebo-controlled trial of galantamine adjunctive treatment to conventional antipsychotics for the cognitive impairments in chronic schizophrenia. International clinical psychopharmacology 20070301
A 2-year open-label study of galantamine therapy in Chinese Alzheimer's disease patients in Hong Kong. International journal of clinical practice 20070301
Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model. Neuropharmacology 20070301
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Treatment of tardive dyskinesia with galantamine: a randomized controlled crossover trial. The Journal of clinical psychiatry 20070301
Pharmacokinetics and bioequivalence studies of galantamine hydrobromide dispersible tablet in healthy male Chinese volunteers. Drug development and industrial pharmacy 20070301
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Anti-Alzheimer drugs: life-threatening adverse effects. Prescrire international 20070201
Quantitative determination of galantamine in human plasma by sensitive liquid chromatography-tandem mass spectrometry using loratadine as an internal standard. Journal of chromatographic science 20070201
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Changes of cholinesterase activities in the plasma and some tissues following administration of L-carnitine and galanthamine to rats. Neuroscience letters 20070116
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Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070101
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Evaluation of the slopes of cognitive impairment and disability in Alzheimer's disease (AD) patients treated with acetylcholinesterase inhibitors (AChEl). Archives of gerontology and geriatrics 20070101
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